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Pronostic Factors and Survival of Colorectal Cancer in Cameroun: A Retrospective Hospital-Based Study 认领
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作者 Jean Paul Engbang Fabien Bekolo Fouda +1 位作者 Ulrich Chanwa Marcelin Ngowe Ngowe 《肠胃病学期刊(英文)》 2021年第3期53-66,共14页
<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> Colorectal cancer represents a major health problem in the </span>... <b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> Colorectal cancer represents a major health problem in the </span><span style="font-family:""><span style="font-family:Verdana;">world today, the 3</span><sup><span style="font-family:Verdana;">rd</span></sup><span style="font-family:Verdana;"> most common cancer and the 2</span><sup><span style="font-family:Verdana;">nd</span></sup><span style="font-family:Verdana;"> in terms of mortality. Despite of the fact that the incidence rate remains the lowest in Africa, it is still a provider of a stronger lethality in most western countries. In Cameroon according to WHO 2018, 421 new cases (4.5% of all cancers) and 451 deaths (4.3% of all cancers) were registered. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> Determine the prognostics factors and the survival of patients suffering from colorectal cancer followed up in Douala. </span><b><span style="font-family:Verdana;">Patients and Method</span></b><span style="font-family:Verdana;">: This was a retrospective cohort study over a period from January 1</span><sup><span style="font-family:Verdana;">st</span></sup><span style="font-family:Verdana;">, 2009 to December 31</span><sup><span style="font-family:Verdana;">st</span></sup><span style="font-family:Verdana;">, 2018. All patients with histo</span><span style="font-family:Verdana;">logically proven colorectal cancer, at the gastroenterological, oncological, </span><span style="font-family:Verdana;">anatomopathological, radiotherapy and surgery Department of Laquintinie and General Hospitals of Douala were included. The data collected were recorded and analyzed by SPSS version 25 and Excel 2016 statistical computer software. Survival was determined by the Kaplan Meier method and the search </span><span style="font-family:Verdana;">for prognostic factors was carried out using the Cox proportional hazards mod</span><span style="font-family:Verdana;">el. The significance l 展开更多
关键词 Colorectal Cancer Prognosis SURVIVAL Douala
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Influence of Age on the Clinical and Prognostic Features of Tetanus in Mali 认领
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作者 Mikaï la Kaboré +14 位作者 Issa Konaté Yacouba Cissoko Jean Paul Dembélé Mariam Soumaré Assetou Fofana Dramane Sogoba Oumar Magassouba Hermine Méli Abdoulaye Zaré Mohamed Aly Cissé Bintou Coulibaly Hama Hamidou Issa Fodé Kouyaté Japhet Dembélé Sounkalo Dao 《临床医学国际期刊(英文)》 2021年第3期77-86,共10页
<strong>Background:</strong> The regression of post-vaccination immunity with age exposes elderly subjects to certain infectious diseases, in particular tetanus. The aim was to compare the clinical and pro... <strong>Background:</strong> The regression of post-vaccination immunity with age exposes elderly subjects to certain infectious diseases, in particular tetanus. The aim was to compare the clinical and prognostic features of tetanus according to the age of patients. <strong>Methodology:</strong> Analytical study of the files of patients hospitalized for tetanus in the Infectious Diseases Department at Point “G” University Teaching Hospital from 2013 to 2019 with retrospective collection. According to age, three groups of patients were formed: group I (<18 years), group II (18 - 59 years) and group III (≥60 years). The study variables were socio-demographic, clinical and prognostic. The One-way ANOVA and Chi-square statistical tests were applied with a significance level p = 0.05. <strong>Results:</strong> In total, 202 cases of tetanus were recorded or 7.3% of admissions. The mean age was 41.9 ± 15.6 years (range, 6 and 85 years) with a sex ratio of 19.2. According to the age grouping, group II was predominant (79.2%) followed by group III (14.9%) with respective mean ages of 39.2 ± 10.6 and 67.3 ± 6.5 and sex ratio of 39 and 29. Workers (33.3%), farmers (25.8%), traders (19.7%) and drivers (7.1%) represented the most important occupations most at risk. Clinically, bad general condition (p < 0.001), trismus (p = 0.001), dysphagia (p = 0.009) and complications during hospitalization (p = 0.028) were seen more frequently in group III patients compared to younger ones. From a prognostic point of view, patients in group III were at greater risk to develop a severe form of tetanus (p = 0.021) with higher mortality compared to other age groups (p < 0.001). <strong>Conclusion:</strong> Tetanus is more prevalent in men. Complications and mortality increase with age. It is important to include booster immunization of adults in existing national programs in order to reduce disease-related morbidity and mortality in this age group. 展开更多
关键词 TETANUS ELDERLY CLINICAL PROGNOSIS MALI
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Maternal and Fetal Prognosis of Evacuated Parturients in N’Djamena Mother and Child Hospital (Chad) 认领
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作者 Lhagadang Foumsou Bray Madoué Gabkika +2 位作者 Foba Kheba Sadjoli Damthéou Salathiel Djongali 《妇产科期刊(英文)》 2021年第3期263-271,共9页
<strong>Introduction</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><strong>:</str... <strong>Introduction</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><strong>:</strong> All pregnant women are at risk of obstetric complications </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">leading to high fetal-maternal mortality and morbidity. The aim of this work was to evaluate the maternal and fetal prognosis of evacuated parturients.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Patient and Method</span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">: we conducted a prospective analytical survey for four months, from April 1</span><sup><span style="font-family:Verdana;">st</span></sup><span style="font-family:Verdana;"> to July 31</span><sup><span style="font-family:Verdana;">st</span></sup><span style="font-family:Verdana;">, 2018 in the Maternity of N’Djamena Mother and Child Hospital about the maternal and fetal prognosis of evacuated parturients. Any parturient evacuated or referred for obstetric complications was included. Study parameters were epidemiological, clinical, para-clinical, therapeutic and prognosis order. These parameters were analyzed in the SPSS 18 French version software.</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Results</span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">: Evacuated parturients represented 20% of maternity admissions. The average age was 23.9 years, with extremes ranging from 15 and 43 years. They were uneducated in 72.9%, primiparous in 46.8% of cases. The three delays were dominated by the 1</span><sup><span style="font-family:Verdana;" 展开更多
关键词 Maternal and Fetal Prognosis Evacuated Parturients Obstetric Complications Mother and Child Hospital N’Djamena CHAD
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Analysis of 154 T4 Colorectal Cancer Patients with Peritoneal Carcinomatosis Treated by Surgery 认领
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作者 Wei Chen Junwen Ye +3 位作者 Xiaoping Tan Yan Zhang Jinglin Liang Meijin Huang 《临床医学国际期刊(英文)》 2021年第2期61-70,共10页
<strong>Objective: </strong>The purpose of this study was to observe the factors related to T4 patients who underwent surgery for colorectal cancer (CRC) with peritoneal carcinomatosis. <strong>Metho... <strong>Objective: </strong>The purpose of this study was to observe the factors related to T4 patients who underwent surgery for colorectal cancer (CRC) with peritoneal carcinomatosis. <strong>Methods: </strong>154 T4 colorectal cancer patients who underwent surgery in the first Affiliated Hospital of Sun Yat-sen University were included in the study between August, 1994 and December, 2005. Some clinical variables were selected and statistically correlated with prognosis. <strong>Results:</strong> The overall survival time was 91.7 months at the end of December of 2010 or death. The complete cytoreduction had significant survival benefit than the palliative surgery group. The age, location, histological grade, complete cytoreduction and liver metastasis were associated with overall survival time (OS) according to the univariate analysis (P < 0.05). In addition, Cox multivariate analysis showed that the complete cytoreduction (CCR) and liver metastasis were independent factor influencing survival. <strong>Conclusion:</strong> Compared with palliative surgery, the incomplete cytoreduction fails to improve patient prognosis. Patients performed completed cytoreduction have a relative good prognosis. 展开更多
关键词 Colorectal Cancer Peritoneal Carcinomatosis SURGERY PROGNOSIS
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Artificial Induction of Labor with Misoprostol: Maternal and Fetal Prognosis at the Referral Health Center of Commune I of the District of Bamako 认领
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作者 Mamadou Bakary Coulibaly Alassane Traoré +5 位作者 Mody Abdoulaye Camara Mamadou Sima Bourama Kané Kalba Tembiné Ibrahima Tégueté Youssouf Traoré 《妇产科期刊(英文)》 2021年第2期70-79,共10页
Artificial induction of labor (AIL) is the set of techniques intended to induce childbirth in order to reduce maternal-fetal mortality. The aim of this paper was to study the maternal and fetal prognosis after the art... Artificial induction of labor (AIL) is the set of techniques intended to induce childbirth in order to reduce maternal-fetal mortality. The aim of this paper was to study the maternal and fetal prognosis after the artificial induction of labor with misoprostol. It was a descriptive prospective study conducted from September 1, 2018 to February 28, 2019 at the maternity unit of the Referral Health Center (RHC) in commune I of Bamako. It was about any pregnant woman at term who had received misoprostol as part of the artificial induction of labor. 102 cases of artificial induction with misoprostol 200 μg were collected out of 3641 deliveries, or a frequency of 2.8%. The age group 28 - 32 years accounted for 56.86% with an average age of 28.8 years. Multiparous represented 54.90% of the number. The history of diabetes and hypertension involved 37.25% of the pregnant women. The main indication was premature rupture of membranes (PRM) (40.2%). Induction was performed between the 37</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> and 41</span><sup><span style="font-family:Verdana;">st</span></sup><span style="font-family:Verdana;"> week of amenorrhea (69.6%). The trigger index according to BISHOP was greater than 7 (50.98%). Induction was done only with 3/4 of misoprostol tablet 200 μg (43.14%). The average labor time was 7 hours (89.22%). The vaginal birth concerned 92.16% of pregnant women. An APGAR10 was noted in 97.85% of newborns after 05 minutes. AIL with misoprostol was practiced at the Center. The main indication was the premature rupture of the membranes. It improves the maternal and fetal prognosis. 展开更多
关键词 Induction MISOPROSTOL Maternal and Fetal Prognosis Commune I
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Necrotizing Fasciitis in Low Income Countries: About 23 Cases of Bujumbura Hospitals 认领
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作者 Jean Claude Niyondiko Evrard Niyonkuru +3 位作者 Gilbert Ndayizeye Stève Nimubona Clovis Paulin Baramburiye Léodégal Bazira 《矫形学期刊(英文)》 2021年第2期33-39,共7页
<b><span>Background:</span></b><span> Necrotizing fasciitis is a rapidly spreading soft tissue infection involving the deep facial layers. It can cause secondary necrosis leading to signi... <b><span>Background:</span></b><span> Necrotizing fasciitis is a rapidly spreading soft tissue infection involving the deep facial layers. It can cause secondary necrosis leading to significant morbidity and mortality. The most important predictor of mortality is a delay in diagnosis. In low income countries, that delay must be high and other predictors of morbidity and mortality must be pointed out. </span><b><span>Objective: </span></b><span>To determine necrotizing fasciitis (NF) prognostic factors in a low income country. </span><b><span>Patients and Methods:</span></b><span> It is a prospective and descriptive study conducted over a one-year period from November 1, 2017 to November 1, 2018 about 23 cases of necrotizing fasciitis in two hospitals of Bujumbura. </span><b><span>Results:</span></b><span> The incidence of necrotizing fasciitis in these 2 hospitals (Kamenge Teaching Hospital and Prince Regent Charles Hospital) was 1%. The average age of patients was 41.76 years. Males were predominant with a sex ratio of 1.55. The risk factors for NF were: NSAIDs in 39%;HIV infection in 13%, diabetes mellitus in 4% and high blood pressure in 4%. The average time from symptoms onset to admission was 17.13 days. The mean time from admission to surgical treatment was 4 days with extremes of 1 to 22 days. The most affected site was the lower limb in 82% of cases. All patients (96%) were treated with necrotic tissue debridement. It was associated with skin grafting in 48% of cases. One patient (4%) with diabetes mellitus and HIV infection was amputated. The mortality rate was 22%</span><span> </span><span>(n = 5). Among those 5 patients, there was a combination of risk factors (diabetes mellitus, NSAID use and HIV infection) in 80% (n = 4), 60% (n = 3) were over 60 years of age and 60% (n = 3) were operated 10 days after the onset of symptoms. The average time of hospital stay was 101 days with extremes of 14 to 400 days. </span><b><span>Conclusion:</span></b><span> Necrotizing fasciitis is associated with a high morta 展开更多
关键词 Necrotizing Fasciitis PROGNOSIS Low Income Countries
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经颅多普勒检测儿童病毒性脑炎脑血流变化及与患儿预后的相关性分析 认领
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作者 李明洋 《黑龙江医学》 2021年第5期531-532,共2页
目的:分析经颅多普勒(Transcranial Doppler,TCD)检测儿童病毒性脑炎脑血流变化及与患儿预后的相关性。方法:回顾性分析2017年1月-2019年1月郑州大学附属儿童医院收治的病毒性脑炎患儿100例临床资料,根据治疗15d后的格拉斯格量表(GOS)... 目的:分析经颅多普勒(Transcranial Doppler,TCD)检测儿童病毒性脑炎脑血流变化及与患儿预后的相关性。方法:回顾性分析2017年1月-2019年1月郑州大学附属儿童医院收治的病毒性脑炎患儿100例临床资料,根据治疗15d后的格拉斯格量表(GOS)评定结果将患儿分为预后优良组(62例)和预后不良组(38例)。两组均行TCD检测,对比分析两组患儿的脑血流动力学情况,并分析其与预后不良的相关性。结果:预后不良组MCA的Vs、Vd,PCA与ACA的Vs、Vd及PI均高于预后优良组,差异有统计学意义(P<0.05);经Pearson分析,MCA的Vs、Vd与患儿预后呈正相关(r>0,P<0.05);PCA的Vs、Vd及PI与预后情况呈正相关(r>0,P<0.05);ACA的Vs、Vd及PI与预后效果呈正相关(r>0,P<0.05)。结论:TCD检测儿童病毒性脑炎脑血流动力学指标与患儿预后效果呈正相关,可通过其变化情况评估患儿短期预后状况。 展开更多
关键词 病毒性脑炎 经颅多普勒 血流变化 预后 相关性
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血清LDL、hs-CRP水平在急性脑梗死患者预后中的应用效果 认领
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作者 张玲 《系统医学》 2021年第5期79-81,共3页
目的对在急性脑梗死患者预后中血清LDL、hs-CRP水平的应用价值进行探究。方法选择该院收治的急性脑梗死患者400例作为该次研究纳入的对象,选取时间段为2018年6月—2019年6月,将其作为病例组,另外选择同时期在该院进行体检的健康人员100... 目的对在急性脑梗死患者预后中血清LDL、hs-CRP水平的应用价值进行探究。方法选择该院收治的急性脑梗死患者400例作为该次研究纳入的对象,选取时间段为2018年6月—2019年6月,将其作为病例组,另外选择同时期在该院进行体检的健康人员100名作为健康组,对两组的血清LDL、hs-CRP水平进行检测,分析血清LDL、hs-CRP水平与急性脑梗死患者预后的关系。结果健康组的LDL水平为(2.0±0.7)mmol/L,hs-CRP为(0.5±0.1)mg/L,病例组的LDL水平为(3.2±0.8)mmol/L,hs-CRP为(2.0±1.5)mg/L。病例组的血清LDL、hs-CRP水平均明显高于健康组,两组患者比较差异有统计学意义(t=3.836、3.227,P<0.05);预后良好组患者入院时的LDL为(1.7±0.4)mmol/L,hs-CRP为(1.0±0.5)mg/L,预后不良组患者入院时的LDL为(4.5±1.3)mmol/L,hs-CRP为(3.0±1.6)mg/L。预后良好组入院时的LDL、hs-CRP水平明显低于预后不良组,差异有统计学意义(t=3.644、4.057,P<0.05)。预后良好组患者出院时的LDL为(1.2±0.1)mmol/L,hs-CRP为(0.3±0.1)mg/L,预后不良组患者出院时的LDL为(3.3±0.2)mmol/L,hs-CRP为(1.9±0.3)mg/L。预后良好组出院时的LDL、hs-CRP水平明显低于预后不良组,差异有统计学意义(t=3.926、3.582,P<0.05)。结论急性脑梗死患者预后情况与血清LDL、hs-CRP水平具有非常密切的关系,在对患者的预后情况进行预测时可以将血清LDL、hs-CRP水平作为重要的辅助指标。 展开更多
关键词 急性脑梗死 预后 血清LDL 血清HS-CRP 预测 效果
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健康宣教标准路径对急性髓系白血病患者负性情绪、生活质量、睡眠质量及预后的影响 认领
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作者 曾春艳 马晓辉 孟炎杰 《癌症进展》 2021年第2期211-214,共4页
目的探讨健康宣教标准路径对急性髓系白血病患者负性情绪、生活质量、睡眠质量及预后的影响。方法采用随机数字表法将96例急性髓系白血病患者分为观察组(n=49)和对照组(n=47),两组患者均给予常规治疗,其中观察组患者给予健康宣教标准路... 目的探讨健康宣教标准路径对急性髓系白血病患者负性情绪、生活质量、睡眠质量及预后的影响。方法采用随机数字表法将96例急性髓系白血病患者分为观察组(n=49)和对照组(n=47),两组患者均给予常规治疗,其中观察组患者给予健康宣教标准路径干预,对照组患者给予常规护理干预。比较干预前和干预3个月后两组患者的焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、生活质量评分、睡眠质量评分及生存情况。结果干预3个月后,观察组患者的SAS、SDS评分均低于对照组,生活质量评分高于对照组,睡眠质量评分低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者呕吐、骨髓抑制、疲乏、出血及口腔黏膜炎的发生率均低于对照组,差异均有统计学意义(P﹤0.05)。观察组和对照组患者的中位生存时间比较,差异无统计学意义(P﹥0.05)。结论健康宣教标准路径有助于改善急性髓系白血病患者的负性情绪、生活质量及睡眠质量,但对患者预后无明显影响。 展开更多
关键词 健康宣教标准路径 急性髓系白血病 负性情绪 生活质量 睡眠质量 预后
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青年胃癌的临床特征及预后影响因素分析 认领
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作者 冯时 周波 曹先东 《中国当代医药》 CAS 2021年第9期9-13,共5页
目的探讨青年胃癌的临床特征及其预后的影响因素。方法收集2013年1月~2017年12月安徽医科大学第一附属医院收治的胃癌患者临床资料,选取经手术治疗的94例Ⅰ~Ⅲ期青年胃癌患者(年龄≤40岁)作为研究组,通过倾向评分匹配(PSM)筛选94例中老... 目的探讨青年胃癌的临床特征及其预后的影响因素。方法收集2013年1月~2017年12月安徽医科大学第一附属医院收治的胃癌患者临床资料,选取经手术治疗的94例Ⅰ~Ⅲ期青年胃癌患者(年龄≤40岁)作为研究组,通过倾向评分匹配(PSM)筛选94例中老年患者(年龄>40岁)作为对照组。比较两组临床资料,探究青年胃癌的临床特征,并分析评估青年胃癌的预后影响因素。结果研究组女性患者比例高于对照组,基础疾病少于对照组,组织学类型分化程度低于对照组,胃近端肿瘤的发病率低于对照组,差异有统计学意义(P<0.05)。两组术后各期累计生存率比较,差异无统计学意义(P>0.05)。单因素分析显示,肿瘤部位、肿瘤大小、淋巴结转移、TNM分期、大体分型、癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原125(CA125)和糖类抗原(CA19-9)与青年胃癌的预后有关(P<0.05)。多因素分析显示,影响青年胃癌预后的独立危险因素为CA125阳性和进展期胃癌(P<0.05)。结论在基线特征匹配的情况下,青年胃癌患者中女性比例相对较高,肿瘤分化程度更低;CA125阳性和进展期胃癌是青年胃癌的不良预后因素。 展开更多
关键词 胃癌 青年 预后 倾向评分匹配法
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卵巢癌患者组织标本HOXA5 IGF-I STIP1表达与疾病预后的相关性 认领
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作者 苑文娜 黄冬梅 《临床心身疾病杂志》 CAS 2021年第2期10-14,共5页
目的探讨卵巢癌患者组织标本同源异型盒基因5、胰岛素样生长因子-I、磷酸化应激诱导蛋白1的表达及其与预后的相关性。方法对卵巢癌组(80例卵巢癌患者)、良性组(35例卵巢良性肿瘤患者)、正常组(35例正常卵巢组织患者)的卵巢组织标本进行... 目的探讨卵巢癌患者组织标本同源异型盒基因5、胰岛素样生长因子-I、磷酸化应激诱导蛋白1的表达及其与预后的相关性。方法对卵巢癌组(80例卵巢癌患者)、良性组(35例卵巢良性肿瘤患者)、正常组(35例正常卵巢组织患者)的卵巢组织标本进行细胞染色,采用免疫组化链菌素亲生物素-过氧化酶连接法检测卵巢组织标本同源异型盒基因5、胰岛素样生长因子-I、磷酸化应激诱导蛋白1表达,并根据染色结果评定阳性表达状况。比较3组间以及不同病理特征、预后卵巢癌患者上述指标阳性表达率,并分析其阳性表达率与临床特征、不良预后的相关性。结果卵巢癌组同源异型盒基因5阳性表达率显著低于良性组、正常组(P<0.01),胰岛素样生长因子-I、磷酸化应激诱导蛋白1阳性表达率显著高于良性组、正常组(P<0.01)。相关分析显示,卵巢癌患者同源异型盒基因5阳性表达率与临床分期、淋巴结转移、不良预后呈显著负相关(P<0.05或0.01),与组织分化程度呈显著正相关(P<0.05);胰岛素样生长因子-I、磷酸化应激诱导蛋白1阳性表达率与卵巢癌患者临床分期、淋巴结转移、不良预后呈显著正相关(P<0.05或0.01),与组织分化程度呈显著负相关(P<0.05或0.01)。结论卵巢癌患者组织标本同源异型盒基因5、胰岛素样生长因子-I、磷酸化应激诱导蛋白1呈异常表达,三者均参与病情进展、淋巴结转移,且与不良预后密切相关。 展开更多
关键词 卵巢癌 同源异型盒基因5 胰岛素样生长因子-I 磷酸化应激诱导蛋白1 预后
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急性心肌梗死患者外周血H2S的表达及临床意义 认领
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作者 王世亚 刘晓峰 +1 位作者 颜永进 顾顺忠 《现代医学》 2021年第2期129-133,共5页
目的:探讨急性心肌梗死(AMI)患者外周血硫化氢(H2S)的表达及临床意义。方法:选取2016年1月-2018年1月在南通大学附属海安医院就诊的AMI患者58例为AMI组,稳定心绞痛(SAP)患者28例为SAP组,选择同期30例健康体检者作为对照组。采用ELIS... 目的:探讨急性心肌梗死(AMI)患者外周血硫化氢(H2S)的表达及临床意义。方法:选取2016年1月-2018年1月在南通大学附属海安医院就诊的AMI患者58例为AMI组,稳定心绞痛(SAP)患者28例为SAP组,选择同期30例健康体检者作为对照组。采用ELISA法检测各组血清H2S水平,ROC曲线评估H2S对AMI诊断及预测主要心血管不良事件(MACE)的价值,采用Cox单因素及多因素回归分析影响AMI患者预后的相关因素。结果:AMI组外周血H2S及心肌肌钙蛋白Ⅰ(cTnI)显著高于SAP组及对照组,差异有统计学意义(P<0.05);诊断AMI时cTnI、H2S的ROC曲线下面积(AUC)分别为0.877、0.805;联合检测AUC为0.918,高于单项检测。单项检测时cTnI敏感性为78.7%,H2S的敏感性为66.5%;二者联合检测诊断AMI敏感性提高到90.6%;外周血H2S预测MACE的AUC为0.797,敏感性为82.2%,特异性为84.6%;高H2S组MACE发生率显著高于低H2S组(χ2=7.803,P=0.005);Cox多因素回归分析结果显示左室射血分数(LVEF)及H2S与AMI患者预后关系密切。结论:AMI患者外周血H2S的表达水平可以作为AMI诊断和预后的新型生物标志物。 展开更多
关键词 急性心肌梗死 H2S 诊断 预后
冠状动脉非阻塞性心肌梗死的病因及预后研究进展 认领
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作者 张依曼 黄宝涛 +1 位作者 时瑞娟 陈茂 《中国全科医学》 CAS 北大核心 2021年第2期132-137,153,共7页
冠状动脉非阻塞性心肌梗死(MINOCA)是一种多病因的临床综合征,其发病率约占急性心肌梗死的5%~25%,近年来在临床上引起普遍关注。由于最新的心肌梗死定义发生了一定变化,使得MINOCA的病因分类也随之有所不同,并且受不同病因的影响,MINOC... 冠状动脉非阻塞性心肌梗死(MINOCA)是一种多病因的临床综合征,其发病率约占急性心肌梗死的5%~25%,近年来在临床上引起普遍关注。由于最新的心肌梗死定义发生了一定变化,使得MINOCA的病因分类也随之有所不同,并且受不同病因的影响,MINOCA患者的预后情况目前尚无定论。本文结合第四版心肌梗死全球统一定义及近年来国内外MINOCA的相关研究,进一步总结归纳了MINOCA的病因及诊断流程,并对其短期预后、中长期预后分别进行了分析阐述,建议诊断为MINOCA的患者应积极探索其潜在病因,以期针对性治疗改善患者预后,并希望未来开展进一步研究探索MINOCA不同的病因对预后的影响。 展开更多
关键词 心肌梗死 冠状动脉非阻塞性心肌梗死 病因 预后
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血清TNF-α、IFN-γ表达对后腹腔镜肾癌部分切除术患者预后的预测价值 认领
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作者 王晨青 索杰 +3 位作者 罗晓辉 王波 黄晓东 王进 《海南医学》 CAS 2021年第1期49-52,共4页
目的探讨血清肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)表达对后腹腔镜肾癌部分切除术患者预后的预测价值。方法回顾性分析2016年3月至2017年3月间于宝鸡市中心医院行后腹腔镜肾癌部分切除术的79例早、中期肾癌患者的临床资料,根据术... 目的探讨血清肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)表达对后腹腔镜肾癌部分切除术患者预后的预测价值。方法回顾性分析2016年3月至2017年3月间于宝鸡市中心医院行后腹腔镜肾癌部分切除术的79例早、中期肾癌患者的临床资料,根据术后3年随访结果分为预后良好组(A组,58例)、预后较差组(B组,21例),并选取71例同期体检正常志愿者为对照组。检测并比较三组受检者的血清TNF-α、IFN-γ表达水平,采用ROC曲线分析血清TNF-α、IFN-γ表达对患者预后的预测价值。结果三组受检者的性别、年龄、体质量指数(BMI)比较差异均无统计学意义(P>0.05);A组与B组患者的病程、肿瘤类型、临床分期、病理分级比较差异均无统计学意义(P>0.05);A组、B组和对照组受检者的血肌酐(Scr)[(102.69±13.28)μmol/L vs(118.29±22.90)μmol/L vs(71.61±10.46)μmol/L]、尿素氮(BUN)[(9.67±2.26)mmol/L vs(11.26±2.89)mmol/L vs(7.35±1.44)mmol/L]比较,A组和B组明显高于对照组,B组明显高于A组,差异均有统计学意义(P<0.05);A组、B组和对照组受检者的血清TNF-α[(3.68±1.18)pg/mL vs(2.09±0.61)pg/mL vs(5.06±1.42)pg/mL]、IFN-γ[(6.88±1.68)pg/mL vs(5.26±1.06)pg/mL vs(8.04±2.25)pg/mL]比较,A组和B组明显低于对照组,B组明显低于A组,差异具有统计学意义(P<0.05);ROC曲线分析结果显示,TNF-α、IFN-γ对后腹腔镜肾癌部分切除术预后具有一定预测价值(AUC=0.814、0.843,P<0.01),且两项联合预测价值较高(AUC=0.901,P<0.01)。结论后腹腔镜肾癌部分切除术患者血清TNF-α、IFN-γ水平表达低者,预后不良发生率较高。 展开更多
关键词 血清肿瘤坏死因子-Α 干扰素-Γ 后腹腔镜肾癌部分切除术 预后 复发转移
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36例口腔颌面-头颈部朗格汉斯细胞组织细胞增多症临床及预后分析 认领
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作者 杨冉冉 鞠侯雨 +1 位作者 任国欣 郭伟 《中国口腔颌面外科杂志》 CAS 2021年第1期52-58,共7页
目的:探讨口腔颌面-头颈部朗格汉斯细胞组织细胞增多症(Langerhans cell histiocytosis,LCH)的临床特征、诊断、治疗方法及预后,为临床治疗提供更强的循证医学证据。方法:回顾分析上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤... 目的:探讨口腔颌面-头颈部朗格汉斯细胞组织细胞增多症(Langerhans cell histiocytosis,LCH)的临床特征、诊断、治疗方法及预后,为临床治疗提供更强的循证医学证据。方法:回顾分析上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科收治的36例成人及儿童口腔颌面-头颈部朗格汉斯细胞组织细胞增多症患者的临床资料,采用SPSS 22.0软件包对其预后进行分析。结果:36例LCH患者中,男女比例为5:1,中位年龄31岁(8个月~74岁)。主要临床表现为口腔黏膜溃疡或肉芽肿,并伴有疼痛、肿胀;颅颌面部骨损害呈穿凿样破坏;牙龈坏死、牙移位、脱落和牙槽骨破坏;22%的患者有尿崩症病史。根据Lavin.Osband计分标准,Ⅰ级26例,Ⅱ级9例,Ⅲ级1例,Ⅳ级0例。最常见的部位为颌骨、牙龈、腭部。23例患者接受单一治疗,13例接受联合治疗。中位随访时间为22.5个月,1例患者失访,1例死亡,初治后完全缓解率为75%,5年无复发生存率为53.78%。接受全身治疗的患者20例;单系统受累患者17例,多系统受累患者19例;24例患者检测BRAF-V600E突变,阳性6例;1例口服靶向药物,效果显著。结论:①口腔颌面-头颈部朗格汉斯细胞组织细胞增多症初治疗效良好,治疗的最终目标是对症处理,延长患者的无复发生存时间。②治疗方式对患者的总生存期有显著影响,化疗可延长患者无复发生存时间;病理确诊后,建议行PETCT,评估全身状况后,根据器官系统受累情况决定治疗方式。③对于一线、二线方案应答不明显的患者,可考虑检测BRAF-V600E基因突变,根据检测结果选择靶向药物。 展开更多
关键词 朗格汉斯细胞组织细胞增多症 临床特征 BRAF-V600E 预后
ICU患者早期系统化护理预防DVT的效果 认领
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作者 刘晓杰 《中国继续医学教育》 2021年第5期183-185,共3页
目的评价早期系统化护理干预在预防ICU患者下肢深静脉血栓DVT方面的价值,以提高ICU患者的安全性。方法选择医院ICU收治的患者,总计90例。治疗期间结合护理方法,进行采取常规护理的对照组和采取早期系统化护理干预的观察组随机分组护理,... 目的评价早期系统化护理干预在预防ICU患者下肢深静脉血栓DVT方面的价值,以提高ICU患者的安全性。方法选择医院ICU收治的患者,总计90例。治疗期间结合护理方法,进行采取常规护理的对照组和采取早期系统化护理干预的观察组随机分组护理,各45例。对比对照组和观察组2组ICU患者的DVT发生率以及股静脉平均血流速度变化情况。结果观察组ICU患者的DVT发生率明显低于对照组,治疗后1周、2组患者股静脉平均血流速度均优于对照组,观察指标对比,差异具有统计学意义,P<0.05。结论对比常规护理,给予ICU患者早期系统性护理干预可以有效预防患者DVT形成、促进患者康复、提高患者生活质量。 展开更多
关键词 ICU患者 早期系统化护理干预 下肢深静脉血栓 效果 生活质量 预后
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川崎病合并巨大冠状动脉瘤101例中长期随访 认领
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作者 熊祎 张永兰 杜忠东 《中华儿科杂志》 CAS CSCD 北大核心 2021年第2期101-106,共6页
目的总结分析川崎病合并巨大冠状动脉瘤(GCAA)患儿的临床特点及中长期预后。方法回顾性队列研究。自首都医科大学附属北京儿童医院2004年建立的川崎病冠状动脉瘤随诊患儿队列中选择符合标准的101例GCAA患儿进行总结。GCAA诊断标准为冠... 目的总结分析川崎病合并巨大冠状动脉瘤(GCAA)患儿的临床特点及中长期预后。方法回顾性队列研究。自首都医科大学附属北京儿童医院2004年建立的川崎病冠状动脉瘤随诊患儿队列中选择符合标准的101例GCAA患儿进行总结。GCAA诊断标准为冠状动脉瘤内径≥8.0 mm,患儿均完成定期随诊。随访终点为患儿最后一次随诊或死亡时间。组间比较采用t检验或χ²检验。结果101例符合纳入标准GCAA患儿入选研究对象,其中男82例(81.2%)、女19例(18.8%);发病年龄2.5(1.0,4.5)岁,随访时间4.5(2.7,7.5)年,最长19年。患儿常规接受阿司匹林、华法林治疗,严重者另加氯吡格雷。截至随访终点,13例(12.9%)患儿出现心脏增大,11例(10.9%)合并心功能不全,13例(12.9%)发生心肌梗死,2例(2.0%)接受冠状动脉搭桥术,6例(5.9%)死亡。受累冠状动脉共170支,位于左侧主干24支(14.1%),左回旋支10支(5.9%),左前降支57支(33.5%),右侧冠状动脉中段78支(45.9%),右侧冠状动脉远段1支(0.6%)。11例(10.9%)患儿GCAA内径回缩至4.0 mm及以下;受累的170支冠状动脉中,28支(16.5%)冠状动脉内径回缩到4.0 mm及以下。左侧、右侧GCAA回缩情况差异无统计学意义[18.7%(17/91)比13.9%(11/79),χ²=2.473,P=0.116]。单侧GCAA与双侧GCAA患儿回缩情况差异无统计学意义[16.1%(9/56)比4.4%(2/45),χ²=2.381,P=0.123]。结论川崎病GCAA以右冠状动脉中段、左冠状动脉前降支最常见,患儿心血管事件发生率及病死率较高,预后欠佳。 展开更多
关键词 粘膜皮肤淋巴结综合征 冠状动脉瘤 预后
细胞免疫治疗晚期卵巢癌的疗效观察 认领
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作者 白力允 白力丹 +3 位作者 谢静 邢俊领 赵红丹 宋士军 《长治医学院学报》 2021年第1期6-9,共4页
目的:探讨细胞免疫治疗对晚期卵巢癌的临床疗效及预后的影响。方法:回顾性分析102例晚期卵巢癌患者的临床资料,实施化疗的为对照组,实施细胞免疫联合化疗的为观察组。比较2组客观缓解率(ORR)、细胞免疫功能及预后情况。结果:观察组ORR... 目的:探讨细胞免疫治疗对晚期卵巢癌的临床疗效及预后的影响。方法:回顾性分析102例晚期卵巢癌患者的临床资料,实施化疗的为对照组,实施细胞免疫联合化疗的为观察组。比较2组客观缓解率(ORR)、细胞免疫功能及预后情况。结果:观察组ORR高于对照组(84.31%vs 54.90%),差异有统计学意义(P<0.05);治疗后观察组CD3+[(63.15±12.36)vs(51.28±12.69)%]、NK指标水平[(25.42±6.15)vs(15.39±6.14)%]及CD4+/CD8+比值[(1.46±0.18)vs(0.98±0.12)]均高于对照组,CD4+CD25+水平低于对照组[(8.16±2.57)vs(10.89±5.27)%],差异均有统计学意义(P<0.05);观察组总毒副反应发生率低于对照组(50.98%vs 72.55%),差异有统计学意义(P<0.05)。结论:细胞免疫联合化疗晚期卵巢癌患者疗效确切,可改善患者细胞免疫功能,降低毒副反应。 展开更多
关键词 细胞免疫 化疗 卵巢癌 免疫功能 预后
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肝门部胆管癌患者癌组织中淋巴增强因子1的表达及P53蛋白突变的临床意义 认领
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作者 田立斌 张海光 刘春玲 《中国综合临床》 2021年第2期112-116,共5页
目的分析淋巴增强因子1(lymphoid enhancer factor-1,LEF-1)与P53蛋白在肝门部胆管癌组织中的表达及临床意义。方法回顾性分析2010年3月至2017年12月唐山市人民医院就诊的50例肝门部胆管癌患者的临床资料,采用免疫组织化学方法检测P53... 目的分析淋巴增强因子1(lymphoid enhancer factor-1,LEF-1)与P53蛋白在肝门部胆管癌组织中的表达及临床意义。方法回顾性分析2010年3月至2017年12月唐山市人民医院就诊的50例肝门部胆管癌患者的临床资料,采用免疫组织化学方法检测P53蛋白突变情况,同时检测LEF1蛋白在胆管癌癌组织及癌旁正常组织中的表达,分析LEF1的表达情况及与临床病理参数的相关性,同时探讨P53蛋白突变情况与LEF1蛋白表达的相关性及与患者预后的关系。结果LEF1蛋白在癌组织的阳性表达率为62.00%(31/50),高于癌旁正常组织的阳性表达率36.00%(18/50),两者比较差异有统计学意义(x2=6.763,P=0.016);P53蛋白突变型的胆管癌患者28例,野生型22例,在P53蛋白突变型的患者中LEF1阳性率为75.00%(21/28),明显高于P53野生型组(45.45%,10/22),两组比较差异有统计学意义(x2=4.565,P=0.03)。LEF1表达与肿瘤的分化程度、TNM分期、淋巴结转移以及P53蛋白突变有关(P均<0.05),LEF-1的表达与P53蛋白突变表达呈正相关(r=0.295,P=0.042)。P53蛋白突变型患者1年累计生存率明显低于P53蛋白野生型患者(60%与81%,P=0.042),LEF1阳性表达患者的1年累计生存率亦明显低于阴性表达患者(53%与82%,P=0.018)。结论LEF-1在肝门部胆管癌组织中高表达,且高表达患者的预后较差。P53蛋白突变的肝门部胆管癌患者LEF-1阳性表达增高,且P53蛋白突变患者预后差。 展开更多
关键词 肝门部胆管癌 淋巴增强因子1 P53蛋白 预后
Long-term outcomes of percutaneous coronary intervention for in-stent chronic total occlusion 认领
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作者 Ming-Lian Gong Yi Mao Jing-Hua Liu 《中华医学杂志:英文版》 SCIE CAS CSCD 2021年第3期302-308,共7页
Background:The development of the technique has improved the success rate of percutaneous coronary intervention(PCI)for instent chronic total occlusion(IS-CTO).However,long-term outcomes remain unclear.The present stu... Background:The development of the technique has improved the success rate of percutaneous coronary intervention(PCI)for instent chronic total occlusion(IS-CTO).However,long-term outcomes remain unclear.The present study sought to investigate long-term outcomes of PCI for IS-CTO.Methods:A total of 474 IS-CTO patients were enrolled at two cardiac centers from 2015 to 2018 retrospectively.These patients were allocated into either successful or failed IS-CTO PCI groups.The primary endpoint(major adverse cardiac events[MACE])consisted of recurrent angina pectoris(RAP),target-vessel myocardial infarction(MI),heart failure,cardiac death,or ischemia-driven target-vessel revascularization(TVR)at follow-up.Multivariable Cox regression analysis was used to investigate the association between treatment appropriateness and clinical outcomes.Results:A total of 367 patients were successfully treated with IS-CTO PCI while 107 patients had failed recanalization.After a median follow-up of 30 months(interquartile range:17-42 months),no significant difference was observed between the two groups for the following parameters:cardiac death(successful PCIvs.failed PCI:0.9%vs.2.7%;adjusted hazard ratio[HR]:1.442;95%confidence interval[CI]:0.21-9.887;P=0.709),RAP(successful PCIvs.failed PCI:40.8%vs.40.0%;adjusted HR:1.025;95%CI:0.683-1.538;P=0.905),heart failure(successful PCIvs.failed PCI:6.1%vs.2.7%;adjusted HR:0.281;95%CI:0.065-1.206;P=0.088),target-vessel related MI(successful PCIvs.failed PCI:1.5%vs.2.7%;adjusted HR:1.150;95%CI:0.221-5.995;P=0.868),MACE(successful PCIvs.failed PCI:44.2%vs.45.3%;adjusted HR:1.052;95%CI:0.717-1.543;P=0.797).More patients were free of angina in the successful IS-CTO PCI group compared with failed PCI in the first(80.4%vs.60%,P<0.01)and second years(73.3%vs.60.0%,P=0.02)following up.Successful IS-CTO PCI had a lower incidence of MACE in the first and second years(20.2%vs.40.0%,P<0.01;27.9%vs.41.3%,P=0.023)compared with failed PCI.After a median follow-up of 30 months,the reocclusion rate was 28.5%and TV 展开更多
关键词 In-stent chronic total occlusion Percutaneous coronary intervention Predictive factor PROGNOSIS
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