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Ossified Subdural Chronic Hematoma: Two Cases Report and Literature Review 认领
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作者 K. Quenum O. H. Fatigba +3 位作者 O. Coulibaly Y. P. Houndje C. Tchegnonsi B. Quenum 《现代神经外科学进展(英文)》 2021年第1期29-33,共5页
Ossified subdural chronic hematoma (OSCH) is a rare disease that accounts 0.3% to 2% of subdural chronic hematoma which is common. The surgical management depends on his clinical expression. The aim of this study is t... Ossified subdural chronic hematoma (OSCH) is a rare disease that accounts 0.3% to 2% of subdural chronic hematoma which is common. The surgical management depends on his clinical expression. The aim of this study is to highlight the surgical procedure because the management of this type of lesion has no consensus. The authors reported two cases of OSCH which were successfully excised with good outcomes. Taking care during the procedure of dissection from parenchyma is the key for this surgery. 展开更多
关键词 Ossified Subdural Chronic Hematoma Calcified Subdural Chronic Hematoma Chronic Hematoma Surgical Treatment
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Dose of Telehealth to Improve Community-Based Care for Adults Living with Multiple Chronic Conditions: A Systematic Review 认领
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作者 Jennifer Mallow Stephen M. Davis +5 位作者 John Herczyk Nathan Pauly Ben Klos Amanda Jones Margaret Jaynes Laurie Theeke 《远程医疗系统和网络(英文)》 2021年第1期20-39,共20页
The purpose of this systematic review is to identify evidence of the appropriate dose of telehealth intervention services provided to community dwelling adults experiencing chronic illness or disability related to eff... The purpose of this systematic review is to identify evidence of the appropriate dose of telehealth intervention services provided to community dwelling adults experiencing chronic illness or disability related to effectiveness, quality, safety, and cost. Academic Search Complete, CINAHL, MEDLINE, Cochrane, and JBI were searched using combinations of “telehealth or telemedicine or telemonitoring or telepractice or telenursing or telecare AND chronic illness or chronic disease”. Of the identified 449 articles, 47 articles met the inclusion criteria. Most study designs were quasi-experimental one group pre-test post-test (N = 16) with few Randomized Controlled Trials (N = 12). Twenty-three published articles studied the effect of telehealth for one chronic condition (49.9%) while 24 (51.1%) examined the effectiveness of telehealth for multiple chronic conditions. Measurement of telehealth outcomes varied and included efficacy, healthcare utilization, quality, adherence, cost, and safety. No standard measure of dose could be extrapolated. Length of intervention was measured and reported differently in each study. The dose of telehealth services that improve care effectiveness, quality, safety, and cost is still unknown for community dwelling adults experiencing chronic illness. The findings from this systematic review do indicate that longer duration of telehealth services (51 weeks), regardless of modality, produced positive outcomes as opposed to those with shorter durations (37 - 38 weeks) that produced neutral or mixed results. Collecting and reporting data related to clinical workflow such as dose of intervention specific to disease and type of modality is recommended. Rigorous study design including standard measurement at the RCT and Comparative Effectiveness level is still needed. 展开更多
关键词 TELEHEALTH TELEMONITORING TELENURSING Chronic Illness Multiple Chronic Conditions WORKFLOW DOSE
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The Endonasal Endoscopic Management of Paranasal Sinuses Mucoceles 认领
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作者 Sarah A. AlMansour Ali A. AlMomen 《耳鼻喉(英文)》 2021年第1期20-29,共10页
<strong>Introduction:</strong> Paranasal sinuses mucoceles are benign, epithelial lined, mucus filled lesions, causing destruction of the adjacent sinus walls, and with further gradual extension to adjacen... <strong>Introduction:</strong> Paranasal sinuses mucoceles are benign, epithelial lined, mucus filled lesions, causing destruction of the adjacent sinus walls, and with further gradual extension to adjacent structures, serious morbidities and mortalities may occur. <strong>Objective:</strong> To emphasize on the efficacy of endonasal endoscopic marsupialization in the treatment of paranasal sinus mucoceles. <strong>Method:</strong> Retrospective descriptive study on paranasal sinus mucocele cases operated on endoscopically by the author (AAM), in the 10-year-period from to 2009-2019. <strong>Result:</strong> Total of 23 cases were included, 16 were males and 7 females, age ranging between 14 - 76 years, with a mean age of 45 years Location of mucoceles varied between: Frontal 7 cases (30%), Fronto-ethmoidal 6 cases (26%), Isolated Ethmoidal accounted for 3 cases (13%), sphenoidal 4 cases (17%), maxillary were 3 cases (13%) all of the 23 cases underwent endonasal endoscopic complete marsupialization, none of them required combination with external approach in-spite of different locations and complications, with no recurrence in a mean follow up period of 2.4 years. <strong>Conclusion:</strong> Endonasal endoscopic approach is a safe, efficient approach in the treatment of most paranasal sinus mucocele case in their different presentations and locations. 展开更多
关键词 MUCOCELE Paranasal Sinus Chronic Rhinosinusitis Endoscopic Sinus Surgery MARSUPIALIZATION
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A New Point of Consideration for the Definition of Minor Ischemic Stroke: Review 认领
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作者 Angela P. Fernandes Sandip Kumar Jaiswal Fu-Ling Yan 《神经系统科学与医药(英文)》 2021年第1期44-54,共11页
<div style="text-align:justify;"> <span style="font-family:Verdana;">Stroke is the second highest cause of death globally and a leading cause of not only physical disability but also co... <div style="text-align:justify;"> <span style="font-family:Verdana;">Stroke is the second highest cause of death globally and a leading cause of not only physical disability but also cognitive. Approximately two-thirds of Ischemic Stroke patients, who represent the most common type of stroke are found to have mild deficits. Minor stroke, sometimes also referred to as “mild stroke”, is often defined in research studies as a National Institute of Health Stroke Scale (NIHSS) score of 5 or less, although, the cut point for NIHSS score or standardized criterion to define minor stroke has not been established. In the past, many studies have been focusing on the definition of the minor stroke to better stabilize the acute treatment guidelines, to predict the functional outcome, and also for early risk factors stratification. Different studies use different criteria or different cut-points of NIHSS scores to define minor stroke. Aside from indecision of acute management of minor stroke, many other questions have been raised regarding minor strokes, for example, the interaction of large vessel occlusion with minor stroke, the prevalence rate of depression, anxiety, cognitive dysfunction, chronic head after minor stroke, and so on. Finding a universal definition for minor stroke is the key to establish the guideline for management for this group of patients. However, the guidance of treatment of minor stroke is not the focus of this review. The review will focus on the deep comprehension of minor stroke characteristics, summarizing the new findings related to minor stroke, and highlight the essential points to consider for characterizing mild stroke symptoms for a new direction guide for future studies.</span> </div> 展开更多
关键词 Mild Stroke Risk Factors NIHSS Score Large Vessel Occlusion Depression Chronic Headache Cognitive Dysfunction
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Evaluation of Thyroid Hormones Levels in Libyan Patients with Chronic Renal Failure before and after Maintenance Hemodialy 认领
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作者 Riad M. Abughalia Milad A. Alrzini Karima R. Zarug Edawib 《应用科学(英文)》 2021年第1期11-20,共10页
Data from recent studies revealed that kidney diseases might affect the thyroid function in various ways. A variety of alterations in thyroid hormone levels and metabolism have also been reported in patients with chro... Data from recent studies revealed that kidney diseases might affect the thyroid function in various ways. A variety of alterations in thyroid hormone levels and metabolism have also been reported in patients with chronic renal failure (CRF) in some studied population. In addition, it was reported that serum levels of both T3 and T4 might alter immediately after a hemodialysis (HD) treatment than before. Therefore, this study was aimed to investigate the level of triiodothyronine (T3) and thyroxine (T4) in CRF Libyan patients before and after HD. This study was carried out on 46 CRF patients (30 males and 16 females) with a mean age of 47.46 ± 15.75 years. These patients were treated at the hemodialysis unit of Educational Central Zelitin Hospital, Zelitin, Libya. None of these patients apparently have any thyroid problems and no history of drug intake that may affect thyroid function. Blood samples were taken from each patient to measure serum levels of T3 and T4, before and after HD. In addition, the effects of several variables including age, gender, body mass index (BMI), presence of both hypertension and, diabetes mellitus and duration of kidney dialysis on serum levels of T3 and T4 before and after HD were also studied. After HD, there was a statistically significant increase in the serum levels of T3, T4. The age, gender, BMI, duration of kidney dialysis and the presence of hypertension and diabetes mellitus did not have any significant effect on the serum level of T3 and T4 before and after HD. However, the serum levels of T3 and T4 were still in the normal range in these examined patients either before or after HD. From these findings, it can be concluded that these CRF patients may be in a euthyroid state, because the serum levels of T3 and T4 were in the normal range. In addition, HD was seemed to improve the T3 and T4 thyroid hormone concentrations, suggesting that HD might activate the secretion of thyroid gland and catabolism. The other variables did not play any role in thyroid hormone levels in th 展开更多
关键词 Chronic Renal Failure (CRF) Hemodialysis (HD) Triiodothyronine (T3) and Thyroxine (T4)
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Correlation between Radiological Staging of Chronic Rhinosinusitis and Revision of Endoscopic Sinus Surgery 认领
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作者 Dhaidan Alshammari Raneem Alshaikh +2 位作者 Manuel Bakheet Waleed Janahi Hiba Alreefy 《耳鼻喉(英文)》 2021年第2期119-130,共12页
<strong>Introduction:</strong> Chronic rhinosinusitis (CRS) is an inflammatory condition affecting the sinonasal mucosa with duration of more than 12 weeks. Multifactorial aetiology contributes to its refr... <strong>Introduction:</strong> Chronic rhinosinusitis (CRS) is an inflammatory condition affecting the sinonasal mucosa with duration of more than 12 weeks. Multifactorial aetiology contributes to its refractoriness. Functional endoscopic sinus surgery (FESS) is the most common surgical technique preferred in CRS not responding to medical management, showing high success rates. However, some failure has been noted, requiring revision FESS. CT (Computed Tomography) is a diagnostic tool for CRS, and aids in improving surgical outcomes. Combined with the Lund-Mackay scoring system, CT can help stage the CRS, predicting the need for revision surgery. <strong>Methods:</strong> In our paper, we aimed to study the relationship between severity of CRS using radiological staging and revision of functional endoscopic sinus surgery, assessing outcome after at least 1 year of follow-up. There was a single centre retrospective study involving 150 patients selected by random sampling, to study the correlation between the severity of chronic rhinosinusitis and revision of functional endoscopic sinus surgery (FESS). The study was conducted in the ENT department of King Hamad University Hospital, Bahrain for a time period of 6 months. Records were scanned and scored using Lund-Mackay system. Lund Mackay score of 10 and above was considered severe. The relation between increased severity with Lund Mackay score on the CT scan and the need for revision sinus surgeries was then determined. <strong>Results and Conclusion:</strong> This study concludes that LMS score in CT scans can be used to predict the outcomes of primary FESS procedure and the need for revision surgery in the management of CRS. 展开更多
关键词 FESS Lund-Mackay System ENT Revision Sinus Surgery Revision FESS Chronic Rhinosinusitis (CRS)
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Effect of Integrated, Person-Centred Palliative Advanced Home and Heart Failure Care on NT-proBNP Levels: A Substudy of the PREFER Study 认领
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作者 Fryxell Jenni Olofsson Mona +1 位作者 Brännström Margareta Boman Kurt 《心血管病(英文)》 2021年第1期1-10,共10页
<strong>Objective:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> In 2012, we initiated a new person-centred model, integrated &... <strong>Objective:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> In 2012, we initiated a new person-centred model, integrated </span><b><span style="font-family:Verdana;">P</span></b><span style="font-family:Verdana;">alliative advanced home ca</span><b><span style="font-family:Verdana;">RE</span></b><span style="font-family:Verdana;"> and heart </span><b><span style="font-family:Verdana;">F</span></b><span style="font-family:Verdana;">ailur</span><b><span style="font-family:Verdana;">E</span></b><span style="font-family:Verdana;"> ca</span><b><span style="font-family:Verdana;">R</span></b><span style="font-family:Verdana;">e (PREFER), to integrate specialised palliative home care with heart failure care. Natriuretic peptide</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">guided treatment is valuable for younger patients (age < 75 years), but its usefulness in palliative care is uncertain. We explored whether patients in PREFER reduced mean level of N-terminal pro B-type natriuretic peptide (NT-proBNP) more than the control group.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Design:</span></b><span style="font-family:Verdana;"> A pre-specified, exploratory substudy, analysed within the prospective, randomised PREFER study, which had an open, non-blinded design.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Participants:</span></b><span style="font-family:Verdana;"> Patients in palliative care with chronic heart failure, New York Heart Association class III-IV were randomly assigned to an intervention (n = 36;26 males, 10 females, mean age:</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">81</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;">9 years) or control group (n = 36;25 males, 11 females, mean age:</span><span style="font-family:;" "=""></span><span style="font-family:Verdana;">76</spa 展开更多
关键词 Chronic Heart Failure Palliative Care Integrated Care NT-PROBNP ELDERLY
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Finding the Needle in the Haystack—An Unusual Case of Astasia-Abasia Following Sacro-Iliac Joint Injection for Chronic Low Back Pain 认领
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作者 Gurmukh Das Punshi Andrew Purcell Camillus Power 《疼痛研究与治疗(英文)》 2021年第1期1-6,共6页
We present the case of a 60 yrs old male who, following a routine, uneventful, fluoroscopically guided L5/S1 facet joint rhizolysis and sacro-iliac joint (SIJ) injection developed an unexpected inability to stand or w... We present the case of a 60 yrs old male who, following a routine, uneventful, fluoroscopically guided L5/S1 facet joint rhizolysis and sacro-iliac joint (SIJ) injection developed an unexpected inability to stand or walk, a condition known as astasia-abasia. Initial concern had been that this neurological phenomenon was as a result of complications of his chronic pain intervention. Despite an essentially normal neurological examination and dedicated battery of neurological imaging and special testing, no cause was identified. Over a 7-day period of in-patient admission and physical rehabilitation symptoms resolved entirely. In the course of the workup for this episode, it was suggested that the phenomenon was the result of a side effect of dexamfetamine, an agent that had been prescribed for the patient by his neurologist for treatment of his narcolepsy. On the back of this episode, this treatment was discontinued by his neurologist following an outpatient consultation. Subsequent repeated SIJ injections were entirely uneventful and the patient experienced no further occurrences of this phenomenon. 展开更多
关键词 Chronic Low Back Pain Sacroiliac Joint Injection Dexamfetamine Astasia-Abasia
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气道上皮细胞在气道慢性炎性疾病中的研究进展 认领
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作者 周方伟(综述) 许昱(审校) 《疑难病杂志》 CAS 2021年第1期99-102,共4页
气道上皮细胞是气道的结构细胞,也是机体对吸入性刺激物、变应原和病原体的第一道防御屏障。气道上皮细胞可以合成和释放多种炎性反应介质和细胞因子,激活先天性和适应性免疫细胞,促进组织的再生和环境因素损害后的修复。气道上皮细胞... 气道上皮细胞是气道的结构细胞,也是机体对吸入性刺激物、变应原和病原体的第一道防御屏障。气道上皮细胞可以合成和释放多种炎性反应介质和细胞因子,激活先天性和适应性免疫细胞,促进组织的再生和环境因素损害后的修复。气道上皮细胞在气道慢性炎性疾病的发生、发展过程中起着重要作用,已成为气道慢性炎性疾病发病机制及治疗靶标的研究热点。文章对气道上皮细胞在慢性鼻窦炎、变应性鼻炎、哮喘和慢性阻塞性肺疾病中的研究进展进行综述。 展开更多
关键词 气道上皮细胞 鼻窦炎 慢性 哮喘 鼻炎 变应性 慢性阻塞性肺疾病
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Risk Factors of Bacterial Resistance to Antibiotics in Internal Medicine and Hemodialysis Nephrology Services at the Edith Lucie Bongo Ondimba General Hospital 认领
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作者 Gandzali-Ngabe Pierre Eric Ngoyi Ontsira Nina +1 位作者 Gakosso Odou Philippe Loumingou Richard 《肾脏病(英文)》 2021年第1期9-20,共12页
Introduction: Antibiotic resistance is a public health problem. It is due to multi-resistant bacteria (MRB). The objective of this study was to determine bacterial resistance to antibiotics in chronic renal failure at... Introduction: Antibiotic resistance is a public health problem. It is due to multi-resistant bacteria (MRB). The objective of this study was to determine bacterial resistance to antibiotics in chronic renal failure at the Edith Lucie BONGO ONDIMBA general hospital (HGELBO). Patients, material and method: This was an analytical cross-sectional study conducted from January 1 to August 31, 2019 at the HGELBO. It concerned all patients admitted to the HGELBO with positive bacteriological samples. After a study of the sensitivity to isolated species, the patients were divided into two (02) groups: those MRB positive (+) and not MRB or negative (-). Epi Info software version 3.5.1 was used for the calculation of the rates and the comparison of the variables. The adjusted odds ratio (ORa) with a 95% confidence interval was used to measure the specific effect of each risk factor such as chronic kidney disease and diabetes, in order to rule out confounding factors. Multivariate analysis by binomial logistic regression was used. Results: There were 375 bacteriological samples from 258 patients, among them 247 patients with 235 positive samples or 63%. The eleven (11) are healthy patients. The median age was 33 with extremes ranging from 16 to 90. The female sex was predominant with a sex ratio of 0.6. The majority of MRB+ cases were found in internal medicine and nephrology with 12 cases (38.7%) and hemodialysis with 4 cases (12.9%). Urinary samples were in the majority with 74.5%. <i>Escherichia coli</i> was predominant in 30.3%. After studying the sensitivity to antibiotics of the 247 species included, 113 were MRB+ and 134 BMR- <i>i.e.</i> a frequency of 45.7%. Methicilin-resistant <i>Staphylococcus aureus</i> (MRSA) was predominant (51.3%). Multivariate logistic regression analysis showed that the main risk factor was antibiotic use (0Ra: 3.2 [1.9 - 5.4];p-value < 0.01). Chronic renal failure and diabetes were not risk factors for carriage. The other risk factors identified were: hospitalization of more than 7 days (pr 展开更多
关键词 Risk Factors Bacterial Resistance ANTIBIOTICS Chronic Renal Failure General Hospital Edith Lucie BONGO ONDIMBA
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Chronic Kidney Disease in Sub-Saharan Africans: A Study of 462 Patients 认领
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作者 Mbengue Mansour Ba Djenaba +2 位作者 Lemrabott Tall Ahmed Cissé Mouhamadou Moustapha Niang Abdou 《肾脏病(英文)》 2021年第1期114-122,共9页
Chronic kidney disease is a global public health problem due to its increasing prevalence as well as its main risk factors such as hypertension and diabetes. However, in Africa, few studies have been done on chronic k... Chronic kidney disease is a global public health problem due to its increasing prevalence as well as its main risk factors such as hypertension and diabetes. However, in Africa, few studies have been done on chronic kidney disease. The aim of our study is to describe the epidemiological, clinical, paraclinical and therapeutic aspects of chronic kidney disease. It was a retrospective and descriptive study carried out from the first of January 2004 to the 31<sup><span style="vertical-align:super;">st</span></sup><span> of December 2013 at Principal hospital in Dakar. Records of any patient aged 18 and over with chronic kidney disease were included. Chronic kidney disease was defined according to the KDIGO 2012 recommendations. Among the 8873 patient records used during our study, 462 presented with chronic kidney disease, which was a hospital prevalence of 5.2%. The sex ratio was 1.61. The mean age of the patients was 58.37 ± 19.97 years. There were 75.32% of </span><span>the patients who were aged 50 and over. The mean serum creatinine was 49.14 </span><span>± 56.83. The mean glomerular filtration rate was 27.47 ± 19.86 ml/min/1.73</span><span> </span><span>m</span><sup><span style="vertical-align:super;">2</span></sup><span>. Chronic renal failure was diagnosed in 92% of patients, including 34.9% in the end-stage of the renal disease. The mean proteinuria was 3.07 ± 4.92</span><span> </span><span>g/24</span><span> </span><span>h. Leukocyturia was present in 34.17% of patients. Hematuria was present in 25% of patients. Hypertension and diabetes were the most common causes, found in 61.25% and 35.93% of patients, respectively. Hemodialysis was performed in 49 patients. Peritoneal dialysis was performed in 2 patients. One patient had undergone a kidney transplant. This study establishes the relatively high prevalence of chronic kidney disease and its risk factors including hypertension and diabetes. It also reveals the late diagnosis of chronic kidney disease in our patients.</span> 展开更多
关键词 Chronic Kidney Disease HYPERTENSION DIABETES
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Parathyroid Hormone as a Marker for the Red Cell Fragility in Different Stages of Chronic Kidney Disease 认领
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作者 Said Sayed Ahmed Khamis Yassin Salah Yassin Mohamed +2 位作者 Heba El Sayed Kasem Thoria Ahmed Omar Hend Samir Mohammed Shaaban 《肾脏病(英文)》 2021年第1期123-132,共10页
<b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> The aim of the work is to study the relationship between Red blood cell ... <b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> The aim of the work is to study the relationship between Red blood cell osmotic fragility and level of parathyroid hormone in patients with different stages of Chronic Kidney Disease including End Stage Renal Disease. </span><b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> Anaemia is one of the common complications associated with Chronic Kidney Disease (CKD) responsible for the increase in the morbidity and mortality in such patients. Several factors have been attributed to caus</span><span style="font-family:Verdana;">ing</span><span style="font-family:Verdana;"> renal anaemia, amongst which hyperparathyroidism is one of the less recognised reasons. The level of PTH in early stages of chronic kidney disease has not been much studied. The excess amount of Parathyroid Hormone (PTH) secondary to CKD has been suggested to be a causative factor for anaemia. </span><b><span style="font-family:Verdana;">Method:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">A</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">number of chronic kidney disease patients were studied for the relationship between Red cell osmotic fragility and level of parathyroid hormone.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> This study was conducted on a number of 111 patients with chronic kidney disease classified into three groups. The study revealed a significant fall in Hb%, along with a rise in Median Osmotic Fragility (MOF) and PTH in the CKD patients. iPTH and MOF were significantly lower in group 3 as compared with cases in group 1. Also, iPTH and MOF were significantly lower in cases in group 2 as compared with cases in group 1. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> 展开更多
关键词 Chronic Kidney Disease Renal Anemia Red Cell Osmotic Fragility Secondary Hyperparathyroidism
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Management of Patients with Inflammatory Bowel Disease during the Prevention of COVID-19 认领
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作者 Ni Ding Huiping Chen Qianqian Ji 《护理学期刊(英文)》 2021年第3期164-169,共6页
<strong>Objective:</strong> To explore the disease management methods and effects for patients with inflammatory bowel disease (IBD) in the special period of pandemic. <strong>Methods:</strong>... <strong>Objective:</strong> To explore the disease management methods and effects for patients with inflammatory bowel disease (IBD) in the special period of pandemic. <strong>Methods:</strong> Medical staffs carried out the management of patients with IBD on the inflammatory disease service platform of this center from February to May of 2020 in addition to routine clinical works.<strong> Results: </strong>None of the nearly 3000 IBD patients who are being followed up at our center were infected with COVID-19. During this period, no patients experienced drug-related serious side effects or disease recurrence that could not be treated in time due to failure to reach the medical staffs. <strong>Conclusion:</strong> The disease management methods based on IBD platform allow the patients to be properly managed during this special period. 展开更多
关键词 COVID-19 Inflammatory Bowel Disease Chronic Disease Management Nursing Care
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Right Ulnar Reconstruction after Sequestrectomy by Non-Vascularized Fibular Transfer in a Girl of Three Years 认领
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作者 Missoki Azanlédji Boume Kwami Edem Edoh Bikor +4 位作者 Yawa Sesime Sanni Nguefack Blanchard Noumedem Cynthia Evlo Vanessa Akakpo Gamédzi Komlatsè Akakpo-Numado 《矫形学期刊(英文)》 2021年第3期73-84,共12页
<p style="text-align:justify;"> <span style="font-family:Verdana;">Chronic osteomyelitis is serious because of the orthopedic sequels that they could cause. Extended diaphyseal sequestr... <p style="text-align:justify;"> <span style="font-family:Verdana;">Chronic osteomyelitis is serious because of the orthopedic sequels that they could cause. Extended diaphyseal sequestrations could cause bone loss and their management is delicate. Here we report a case of right ulnar diaphyseal reconstruction by non-vascularized fibula transfer. This was a three-year-old girl, non-sickle cell, who had chronic osteomyelitis of the right ulna. The evolution was towards an almost total ulnar diaphyseal sequestration with externalization of the distal extremity. The removal of this large sequestrum occurred almost spontaneously, leaving a significant bone loss over a length of about 6 cm. Secondarily, we reconstructed the right ulnar diaphysis by transfer of a free non-vascularized graft of the left fibula, maintained by a pin. </span><span style="font-family:Verdana;">The follow up was favorable with almost complete recovery of pro</span><span style="font-family:Verdana;">no-supination. Fibular ossification has evolved as well and we did not notice any complications at the graft collection site. Non-vascularized fibula graft transfer is a useful therapeutic option in the management of significant bone defect</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> secondary to chronic osteomyelitis of one of the two forearm bones.</span> </p> 展开更多
关键词 Free Fibula Transfer Chronic Osteomyelitis ULNA Child Togo
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Retroperitoneal laparoscopic partial resection of the renal pelvis for urothelial carcinoma:A case report 认领
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作者 Yan-Long Wang Hong-Lin Zhang +4 位作者 Hao Du Wei Wang Hai-Feng Gao Guang-Hai Yu Yu Ren 《世界临床病例杂志》 SCIE 2021年第8期1916-1922,共7页
BACKGROUND The standard treatment of transitional cell carcinoma of the upper urinary tract consists of radical nephroureterectomy with bladder cuff removal,which can be performed either in open or laparoscopy or robo... BACKGROUND The standard treatment of transitional cell carcinoma of the upper urinary tract consists of radical nephroureterectomy with bladder cuff removal,which can be performed either in open or laparoscopy or robot-assisted laparoscopy.Treatment of chronic renal insufficiency patients with upper urothelial tumor is in a dilemma.Urologists weigh and consider the balance between tumor control and effective renal function preservation.European Association of Urology guidelines recommend that select patients may benefit from endoscopic treatment,but laparoscopic treatment is rarely reported.CASE SUMMARY In this case report,we describe a case of 79-year-old female diagnosed with urothelial carcinoma of the renal pelvis and adrenal adenoma with chronic renal insufficiency.The patient was treated with retroperitoneal laparoscopic partial resection of the renal pelvis and adrenal adenoma resection simultaneously.CONCLUSION Retroperitoneal laparoscopic partial resection of the renal pelvis is an effective surgical procedure for the treatment of urothelial carcinoma of the renal pelvis. 展开更多
关键词 Transitional cell carcinoma Kidney sparing Chronic renal insufficiency LAPAROSCOPY Partial resection of the renal pelvis New effective surgical method
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原研伊马替尼治疗慢性髓性白血病慢性期3个月、6个月分子生物学反应对预后评估及制定有效治疗方案的意义 认领
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作者 王宁 杜新 +1 位作者 张晓瀚 朱锦灿 《吉林医学》 CAS 2021年第3期564-567,共4页
目的:评价原研伊马替尼(格列卫)治疗初发慢性髓性白血病慢性期(CML-CP)患者3个月、6个月早期分子学反应(EMR)对远期疗效的影响。方法:回顾性分析71例新诊断CML-CP患者,给予格列卫400 mg,1次/d,口服,评价3个月、6个月时国际化标准BCR-ABL... 目的:评价原研伊马替尼(格列卫)治疗初发慢性髓性白血病慢性期(CML-CP)患者3个月、6个月早期分子学反应(EMR)对远期疗效的影响。方法:回顾性分析71例新诊断CML-CP患者,给予格列卫400 mg,1次/d,口服,评价3个月、6个月时国际化标准BCR-ABL1(BCR-ABL1IS)转录本水平、随访时间内累积完全细胞遗传学反应(CCyR)率、累积主要分子学反应(MMR)率、无病生存(EFS)率。结果:3个月时,71例患者均格列卫治疗≥3个月,其中46例(64.8%)BCR-ABL1IS≤10%,25例(35.2%)BCR-ABL1IS>10%,差异有统计学意义(P<0.001)。获得EMR患者累积MMR率和累积CCyR率优于BCR-ABL1IS>10%的患者,差异有统计学意义(95.7%vs 65.0%,P=0.001;95.7%vs 60.0%,P<0.001);6个月时,有66例患者可供评估,其中43例(65.1%)BCR-ABL1IS<1%,23例(34.9%)BCR-ABL1IS≥1%,差异有统计学意义(65.1%vs 34.9%,P<0.001);6个月时获得EMR患者累积MMR率和累积CCyR率优于BCR-ABL1IS≥1%的患者,差异有统计学意义(90.5%vs 50.0%,P<0.001;92.9%vs 60.0%:P=0.002);3个月、6个月获得EMR患者无病生存(EFS)率优于非EMR患者,差异有统计学意义(P=0.011和P<0.001)。结论:原研伊马替尼治疗初发CML-CP 3个月、6个月EMR预示较高的累积MMR率、累积CCyR率和EFS率,是良好的预后指标,可以作为早期治疗调整的参考。 展开更多
关键词 白血病 髓性 慢性 原研伊马替尼(格列卫) BCR-ABL1 早期分子学反应
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慢性乙型肝炎肝纤维化无创性诊断模型的创建及验证 认领
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作者 张华堂 余雪平 +3 位作者 李菊兰 郑怡娟 郑明慧 苏智军 《中国卫生标准管理》 2021年第6期136-138,共3页
目的从临床常见血清学等指标中构建肝纤维化无创性诊断模型,并评价模型的诊断效能。方法符合入组标准的326例慢性乙型肝炎(Chronic hepatitis B,CHB)患者,于2006年4月—2017年10月在泉州市第一医院行肝活检,以6:4比例将上述患者随机分... 目的从临床常见血清学等指标中构建肝纤维化无创性诊断模型,并评价模型的诊断效能。方法符合入组标准的326例慢性乙型肝炎(Chronic hepatitis B,CHB)患者,于2006年4月—2017年10月在泉州市第一医院行肝活检,以6:4比例将上述患者随机分为建模组(197例)和验证组(129例)。应用建模组数据创建模型FM,评价FM诊断能力使用受试者工作特征曲线(receiver operating characteristic,ROC)。结果在建模组,年龄、血小板、总胆红素、白蛋白及Ln(HBV-DNA)衍生出无创诊断模型FM。在建模组,FM诊断显著肝纤维化AUROC为0.900,优于FIB-4(0.745,P=0.0349)、APRI(0.711,P=0.0365)、GPR(0.680,P=0.0377)。在验证组,FM诊断显著性肝纤维化的AUROC为0.843,优于APRI(0.698,P=0.0067)、FIB-4(0.660,P=0.0003)、GPR(0.721,P=0.0106)。结论由年龄、PLT、ALB、Ln(HBV-DNA)、TBIL五个参数构成的无创模型FM预测显著肝纤维化的价值均优于经典模型GPR、APRI、FIB-4。 展开更多
关键词 肝纤维化 模型 乙型肝炎 肝穿刺术 慢性 无创性
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慢性乙型肝炎病人外周血单个核细胞内微小RNA-155、核苷酸结合寡聚化结构域样3表达与乙型肝炎病毒DNA载量的相关性 认领
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作者 刘宏伟 王玉华 《安徽医药》 CAS 2021年第2期373-377,共5页
目的研究慢性乙型肝炎(CHB)病人外周血单个核细胞(PBMC)内微小RNA-155(Mir-155)、核苷酸结合寡聚化结构域样3(NLRP3)表达与乙型肝炎病毒DNA(HBV-DNA)载量的相关性。方法选取2017年6月至2019年9月沧州市传染病医院收治的经肝脏穿刺病理... 目的研究慢性乙型肝炎(CHB)病人外周血单个核细胞(PBMC)内微小RNA-155(Mir-155)、核苷酸结合寡聚化结构域样3(NLRP3)表达与乙型肝炎病毒DNA(HBV-DNA)载量的相关性。方法选取2017年6月至2019年9月沧州市传染病医院收治的经肝脏穿刺病理确诊的CHB病人118例为研究对象,根据荧光定量聚合酶链式反应(RT-qPCR)检测HBV-DNA载量分为低载量组(HBV-DNA<1×10^5拷贝/毫升)51例,中载量组(1×10^5拷贝/毫升≤HBV-DNA1×10^7拷贝/毫升)38例,高载量组(HBV-DNA>1×10^7拷贝/毫升)29例,另选取同期门诊健康体检者118例为健康对照组。采用RT-qPCR检测两组PBMC内Mir-155、NLRP3 mRNA及蛋白表达水平,采用酶联免疫吸附试验(ELISA)检测血清白细胞介素-1β(IL-1β)、白细胞介素-18(IL-18)水平,采用Pearson法分析CHB病人Mir-155与NLRP3蛋白水平及二者分别与IL-1β、IL-18水平的相关性。结果与健康对照组比较,CHB病人血清肝功能指标天门冬氨酸氨基转移酶(AST)[(18.17±3.65)mmol/L比(52.06±10.57)mmol/L]、丙氨酸氨基转移酶(ALT)[(22.84±4.56)mmol/L比(58.93±11.74)mmol/L]、PBMC中Mir-155[(1.01±0.16)比(3.42±0.53)]、NLRP3 mRNA[(1.02±0.15)比(4.26±0.75)]水平均显著升高(P<0.05)。与HBV-DNA低载量组比较,中、高载量组CHB病人PBMC中Mir-155、NLRP3 mRNA及蛋白水平、血清IL-1β、IL-18水平依次增加(P<0.05)。随肝炎炎症分级增加、肝纤维化分期增加,PBMC中Mir-155、NLRP3 mRNA水平依次增加(均P<0.05)。CHB病人PBMC中Mir-155与NLRP3、IL-1β、IL-18水平均呈显著正相关(r=0.714、0.733、0.852,P<0.05),NLRP3水平与血清IL-1β、IL-18水平均呈显著正相关(r 0.685、0.812,P<0.05)。结论随HBV-DNA载量增加,CHB病人Mir-155、NLRP3水平增加,可能协同促进炎症反应影响CHB发生发展。 展开更多
关键词 乙型肝炎 慢性 乙型肝炎病毒 微小RNA-155 核苷酸结合寡聚化域3
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以个体需求为导向的健康教育在老年慢性心功能不全患者护理中的应用 认领
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作者 李杨 《中国实用乡村医生杂志》 2021年第2期43-45,49,共4页
目的探讨以个体需求为导向的健康教育在老年慢性心功能不全(CHF)患者中应用效果.方法选择2020年1—6月营口市中心医院收治的老年CHF患者70例,随机分为对照组和研究组各35例.分别以明尼苏达心衰生活质量表(MLHFQ)和一般自我效能感量表(GS... 目的探讨以个体需求为导向的健康教育在老年慢性心功能不全(CHF)患者中应用效果.方法选择2020年1—6月营口市中心医院收治的老年CHF患者70例,随机分为对照组和研究组各35例.分别以明尼苏达心衰生活质量表(MLHFQ)和一般自我效能感量表(GSES)评价两组患者干预前后生活质量和自我效能改善情况.结果干预后,研究组身体领域、情绪领域、其他领域及总分均低于对照组,差异有统计学意义(P<0.05);研究组GSES评分构成情况优于对照组,差异有统计学意义(P<0.05).结论以个体需求为导向的健康教育能进一步改善老年CHF的生活质量和自我效能,值得临床推广应用. 展开更多
关键词 心功能不全 慢性 老年 健康教育 个体需求 生活质量 自我效能
Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients 认领
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作者 Moises Martinez-Castillo Abigail Hernandez-Barragan +10 位作者 Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes 《世界肝病学杂志:英文版(电子版)》 2021年第2期218-232,共15页
BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few s... BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few studies on the regulation of liver MMPs in fibrosis progression in humans.AIM To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C(CHC).METHODS A prospective,cross-sectional,multicenter study was conducted.CHC patients were categorized in fibrosis grades through FibroTest®and/or FibroScan®.Serum MMP-2,-7,and-9 were determined by western blot and multiplex suspension array assays.Differences were validated by the Kruskal-Wallis and Mann-Whitney U tests.The Spearman correlation coefficient and area under the receiver operating characteristic curve were calculated.Collagenolytic and gelatinase activity was determined through the Azocoll substrate and zymogram test,whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot assays.RESULTS Serum concentrations of the MMPs evaluated were higher in CHC patients than in healthy subjects.MMP-7 distinguished early and advanced stages,with a correlation of 0.32(P<0.001),and the area under the receiver operating characteristic displayed moderate sensitivity and specificity for MMP-7 in F4(area under the receiver operating characteristic,0.705;95%confidence interval:0.605-0.805;P<0.001).Collagenolytic activity was detected at F0 and F1,whereas gelatinase activity was not detected at any fibrosis stage.Tissue inhibitor of metalloproteinase-1 determination showed upregulation in F0 and F1 but downregulation in F2(P<0.001).CONCLUSION High concentrations of inactive MMPs were present in the serum of CHC patients,reflecting the impossibility to restrain liver fibrosis progression.MMPs could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC. 展开更多
关键词 Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C FIBROGENESIS Fibrolysis
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