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人类与猕猴大脑的同源脑区研究综述 认领
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作者 王千山 王玥 +2 位作者 柴静文 李斌强 李海芳 《太原理工大学学报》 CAS 北大核心 2021年第2期274-281,共8页
探索大脑的结构和功能是本世纪最前沿的科学问题。灵长类动物的大脑之间具有较高的相似性,研究结果可以进行物种间的推广。由于对人类大脑进行生物实验受到诸多限制,研究者越来越关注非人灵长类动物大脑研究。通过综述大脑研究中人类和... 探索大脑的结构和功能是本世纪最前沿的科学问题。灵长类动物的大脑之间具有较高的相似性,研究结果可以进行物种间的推广。由于对人类大脑进行生物实验受到诸多限制,研究者越来越关注非人灵长类动物大脑研究。通过综述大脑研究中人类和猕猴的同源脑区相关研究的进展情况。收集整理已发表的各类大脑图谱相关文章,筛选出适合人猴大脑同源性研究使用的图谱。对跨物种比较研究中提及的可能具有同源性的脑区进行梳理,根据采用的研究方法进行筛选,总结出25对同源关系较为明确的人类和猕猴大脑同源区域及其标记图谱。有助于研究人员进一步探索大脑工作机制。 展开更多
关键词 大脑 猕猴 跨物种比较 同源脑区 脑图谱
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文章速递Localization of the hydrogen sulfide and oxytocin systems at the depth of the sulci in a porcine model of acute subdural hematoma 认领
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作者 Oscar McCook Angelika Scheuerle +3 位作者 Nicole Denoix Thomas Kapapa Peter Radermacher Tamara Merz 《中国神经再生研究:英文版》 SCIE CAS CSCD 2021年第12期2376-2382,共7页
In the porcine model discussed in this review,the acute subdural hematoma was induced by subdural injection of autologous blood over the left parietal cortex,which led to a transient elevation of the intracerebral pre... In the porcine model discussed in this review,the acute subdural hematoma was induced by subdural injection of autologous blood over the left parietal cortex,which led to a transient elevation of the intracerebral pressure,measured by bilateral neuromonitoring.The hematoma-induced brain injury was associated with albumin extravasation,oxidative stress,reactive astrogliosis and microglial activation in the ipsilateral hemisphere.Further proteins and injury markers were validated to be used for immunohistochemistry of porcine brain tissue.The cerebral expression patterns of oxytocin,oxytocin receptor,cystathionine-γ-lyase and cystathionine-β-synthase were particularly interesting:these four proteins all co-localized at the base of the sulci,where pressure-induced brain injury elicits maximum stress.In this context,the pig is a very relevant translational model in contrast to the rodent brain.The structure of the porcine brain is very similar to the human:the presence of gyri and sulci(gyrencephalic brain),white matter to grey matter proportion and tentorium cerebelli.Thus,pressure-induced injury in the porcine brain,unlike in the rodent brain,is reflective of the human pathophysiology. 展开更多
关键词 animal modeling brain edema cystathionine-β-synthase cystathionine-γ-lyase gyrencephalic brain immunohistochemistry intensive care unit large animal model neuromonitoring oxytocin receptor
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文章速递Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway 认领
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作者 Cheng-di Liu Nan-nan Liu +4 位作者 Sen Zhang Guo-dong Ma Hai-guang Yang Ling-lei Kong Guan-hua Du 《中国药理学报:英文版》 SCIE CAS CSCD 北大核心 2021年第3期370-381,共12页
Stroke is an acute cerebrovascular disease caused by ruptured or blocked blood vessels.For the prevention of ischemic stroke,the coagulation state of blood and cerebrovascular protection should be considered.Our previ... Stroke is an acute cerebrovascular disease caused by ruptured or blocked blood vessels.For the prevention of ischemic stroke,the coagulation state of blood and cerebrovascular protection should be considered.Our previous study has shown that salvianolic acid A(SAA),which is a water-soluble component from the root of Salvia Miltiorrhiza Bge,prevents thrombosis with a mild inhibitory effect on platelet aggregation.In this study we investigated the preventive effects of SAA on cerebrovascular endothelial injury caused by ischemia in vivo and oxygen-glucose deprivation(OGD)in vitro,and explored the underlying mechanisms.An autologous thrombus stroke model was established in SD rats by electrocoagulation.SAA(10 mg/kg)was orally administered twice a day for 5 days before the operation.The rats were sacrificed at 24 h after the operation.We showed that pretreatment with SAA significantly improved the neurological deficits,intracerebral hemorrhage,BBB disruption,and vascular endothelial dysfunction as compared with model group.In human brain microvascular endothelial cells(HBMECs),pretreatment with SAA(10μM)significantly inhibited OGD-induced cell viability reduction and degradation of tight junction proteins(ZO-1,occludin,claudin-5).Furthermore,we found that SAA inhibited the upregulation of Src signaling pathway in vivo and vitro and reversed the increased expression of matrix metalloproteinases(MMPs)after ischemic stroke.In conclusion,our results suggest that SAA protects cerebrovascular endothelial cells against ischemia and OGD injury via suppressing Src signaling pathway.These findings show that pretreatment with SAA is a potential therapeutic strategy for the prevention of ischemic stroke. 展开更多
关键词 salvianolic acid A ischemic stroke cerebrovascular endothelial injury blood brain barrier Src autologous thrombus stroke model human brain microvascular endothelial cells
Bloodletting Puncture at Hand Twelve Jing-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway 认领
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作者 LIU Bao-hu ZHOU Dan +7 位作者 GUO Yi ZHANG Sai GUO Yong-ming GUO Tong-tong CHEN Xu-yi GONG Yi-nan TANG Hui-ling XU Zhi-fang 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2021年第4期291-299,共9页
Objective:To investigate whether blood-brain barrier(BBB)served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points(HTWP)in traumatic brain injury(TBI)and the potential molec... Objective:To investigate whether blood-brain barrier(BBB)served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points(HTWP)in traumatic brain injury(TBI)and the potential molecular signaling pathways.Methods:Adult male Sprague-Dawley rats were assigned to the shamoperated(sham),TBI,and bloodletting puncture(bloodletting)groups(n=24 per group)using a randomized number table.The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days.The neurological function and cerebral edema were evaluated by modified neurological severity score(mNSS),cerebral water content,magnetic resonance imaging and hematoxylin and eosin staining.Cerebral blood flow was measured by laser speckles.The protein levels of aquaporin 4(AQP4),matrix metalloproteinases 9(MMP9)and mitogen-activated protein kinase pathway(MAPK)signaling were detected by immunofluorescence staining and Western blot.Results:Compared with TBI group,bloodletting puncture improved neurological function at 24 and 48 h,alleviated cerebral edema at 48 h,and reduced the permeability of BBB induced by TBI(all P<0.05).The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by bloodletting puncture(P<0.05 or P<0.01).In addition,the extracellular signal-regulated kinase(ERK)and p38 signaling pathways were inhibited by bloodletting puncture(P<0.05).Conclusions:Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling pathways.Therefore,bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema. 展开更多
关键词 traumatic brain injury cerebral edema blood brain barrier bloodletting puncture at hand twelve Jing-well points mitogen-activated protein kinase pathway Chinese medicine
Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury 认领
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作者 Zi-Qi Shao Shan-Shan Dou +4 位作者 Jun-Ge Zhu Hui-Qing Wang Chun-Mei Wang Bao-Hua Cheng Bo Bai 《中国神经再生研究:英文版》 SCIE CAS CSCD 2021年第6期1044-1051,共8页
Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled receptor,and it may be neuroprotective against cerebral ischemia injury.However,the precise mechanisms of the effects of apelin-1... Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled receptor,and it may be neuroprotective against cerebral ischemia injury.However,the precise mechanisms of the effects of apelin-13 remain to be elucidated.To investigate the effects of apelin-13 on apoptosis and autophagy in models of cerebral ischemia/reperfusion injury,a rat model was established by middle cerebral artery occlusion.Apelin-13(50μg/kg)was injected into the right ventricle as a treatment.In addition,an SH-SY5Y cell model was established by oxygen-glucose deprivation/reperfusion,with cells first cultured in sugar-free medium with 95%N2 and 5%CO2 for 4 hours and then cultured in a normal environment with sugar-containing medium for 5 hours.This SH-SY5Y cell model was treated with 10-7 M apelin-13 for 5 hours.Results showed that apelin-13 protected against cerebral ischemia/reperfusion injury.Apelin-13 treatment alleviated neuronal apoptosis by increasing the ratio of Bcl-2/Bax and significantly decreasing cleaved caspase-3 expression.In addition,apelin-13 significantly inhibited excessive autophagy by regulating the expression of LC3B,p62,and Beclin1.Furthermore,the expression of Bcl-2 and the phosphatidylinositol-3-kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR)pathway was markedly increased.Both LY294002(20μM)and rapamycin(500 nM),which are inhibitors of the PI3K/Akt/mTOR pathway,significantly attenuated the inhibition of autophagy and apoptosis caused by apelin-13.In conclusion,the findings of the present study suggest that Bcl-2 upregulation and mTOR signaling pathway activation lead to the inhibition of apoptosis and excessive autophagy.These effects are involved in apelin-13-induced neuroprotection against cerebral ischemia/reperfusion injury,both in vivo and in vitro.The study was approved by the Animal Ethical and Welfare Committee of Jining Medical University,China(approval No.2018-JS-001)in February 2018. 展开更多
关键词 central nervous system brain brain injury factor pathways apoptosis AUTOPHAGY NEUROPROTECTION regeneration
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Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats 认领
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作者 Qiu-Shi Gao Ya-Han Zhang +3 位作者 Hang Xue Zi-Yi Wu Chang Li Ping Zhao 《中国神经再生研究:英文版》 SCIE CAS CSCD 2021年第6期1052-1061,共10页
Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.The classical Rice-Va... Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury,and newborn(postnatal day 7)rats were treated with 2.4%sevoflurane for 30 minutes after hypoxic-ischemic injury.Our results showed that sevoflurane postconditioning significantly improved the learning and memory function of rats,decreased astrogliosis and glial scar formation,increased numbers of dendritic spines,and protected the histomorphology of the hippocampus.Mechanistically,sevoflurane postconditioning decreased expression of von Hippel-Lindau of hypoxia-inducible factor-1α and increased expression of DJ-1.Injection of 1.52μg of the hypoxia-inducible factor-1αinhibitor YC-1(Lificiguat)into the left lateral ventricle 30 minutes before hypoxic-ischemic injury reversed the neuroprotection induced by sevoflurane.This finding suggests that sevoflurane can effectively alleviate astrogliosis in the hippocampus and reduce learning and memory impairments caused by glial scar formation after hypoxic-ischemic injury.The underlying mechanism may be related to upregulated DJ-1 expression,reduced ubiquitination of hypoxia-inducible factor-1α,and stabilized hypoxiainducible factor-1αexpression.This study was approved by the Laboratory Animal Care Committee of China Medical University,China(approval No.2016PS337K)on November 9,2016. 展开更多
关键词 brain injury brain central nervous system in vivo injury model PLASTICITY rat recovery regeneration repair
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Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage 认领
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作者 Liu-Lin Xiong Jie Chen +7 位作者 Ruo-Lan Du Jia Liu Yan-Jun Chen Mohammed Al Hawwas Xin-Fu Zhou Ting-Hua Wang Si-Jin Yang Xue Bai 《中国神经再生研究:英文版》 SCIE CAS CSCD 2021年第8期1453-1459,共7页
Brain-derived neurotrophic factor(BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated fac... Brain-derived neurotrophic factor(BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated factors following hypoxia-ischemia induced neonatal brain damage, and the significance of these changes are not fully understood. In the present study, a rat model of hypoxic-ischemic brain damage was established through the occlusion of the right common carotid artery, followed by 2 hours in a hypoxic-ischemic environment. Rats with hypoxic-ischemic brain damage presented deficits in both sensory and motor functions, and obvious pathological changes could be detected in brain tissues. The m RNA expression levels of BDNF and its processing enzymes and receptors(Furin, matrix metallopeptidase 9, tissuetype plasminogen activator, tyrosine Kinase receptor B, plasminogen activator inhibitor-1, and Sortilin) were upregulated in the ipsilateral hippocampus and cerebral cortex 6 hours after injury;however, the expression levels of these m RNAs were found to be downregulated in the contralateral hippocampus and cerebral cortex. These findings suggest that BDNF and its processing enzymes and receptors may play important roles in the pathogenesis and recovery from neonatal hypoxic-ischemic brain damage. This study was approved by the Animal Ethics Committee of the University of South Australia(approval No. U12-18) on July 30, 2018. 展开更多
关键词 brain injury brain-derived neurotrophic factor ENZYME HYPOXIA-ISCHEMIA RECEPTORS recovery repair
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Survival and effective prognostic factors in lung cancer patients with brain metastases treated with whole brain radiotherapy 认领
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作者 Bixin Ren Li Zou +1 位作者 Qi Guo Ye Tian 《放射医学与防护》 2021年第1期5-12,共8页
Objective:To evaluate the outcomes and explore the risk factors for survival of lung cancer patients with brain metastases(BMs)who were treated with whole brain radiotherapy(WBRT)and to identify the significance of th... Objective:To evaluate the outcomes and explore the risk factors for survival of lung cancer patients with brain metastases(BMs)who were treated with whole brain radiotherapy(WBRT)and to identify the significance of the risk factors.Methods:A retrospective analysis was carried out for lung cancer patients with BMs who were treated with WBRT in the Second Affiliated Hospital of Soochow University from January 2014 to December 2017.Their survival time was calculated using the Kaplan-Meier method.Meanwhile,the neutrophil-lymphocyte ratio(NLR)cutoff values were defined using the receiver operating characteristic(ROC)curve analysis,and the characteristics of different NLR groups were compared using the Wilcoxon Rank Sum Test.Results:A total of 179 patients were assessed.Their median overall survival(OS)was 9.9(95%CI 7.08–12.72)months.As shown by univariate analyses,their OS was significantly affected by histology(P<0.001),number of BMs(P=0.009),local treatment of BMs(P=0.019),Karnofsky Performance Status score(P=0.001),Graded Prognostic Assessment(GPA)score(P<0.001),hemoglobin level(P=0.002),lymphocyte count(P=0.006),albumin level(P=0.001),and NLR(P<0.001).Meanwhile,according to multivariate analyses,independent risk factors for OS included non-adenocarcinoma(ADCA)histology(P<0.001)and high NLR(P=0.006).Moreover,the optimal NLR cutoff value was determined to be 7.0.The patients in this study were divided into three categories based on their total score determined by assigning each risk factor of histology and NLR one point.The median survival in the patients with scores of 0,1,and 2 was 19.6 months,8.5 months,and 2.2 months,respectively(P=0.001).The survival time and prognostic factors of different pathological types of patients were further analyzed.As a result,the median OS of patients with small-cell lung cancer(SCLC),ADCA patients receiving targeted therapy,and ADCA patients not receiving targeted therapy was 10.9 months,13.2 months,and 9.5 months,respectively.The results of multivariate analyses all showed that 展开更多
关键词 Whole brain radiotherapy Lung cancer Brain metastasis Overall survival Neutrophil-lymphocyte ratio(NLR)
A Qualitative Study on the Negative Emotions of Mothers during Chemotherapy of Their Children with Malignant Brain Tumors 认领
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作者 Zhihuan Zhou Lan Bai Qinqin Zhao 《癌症治疗(英文)》 2021年第1期1-9,共9页
<strong>Objective:</strong> <span><span><span style="font-family:""><span style="font-family:Verdana;">To explore the negative emotions of mothers during ch... <strong>Objective:</strong> <span><span><span style="font-family:""><span style="font-family:Verdana;">To explore the negative emotions of mothers during chemotherapy of their children with malignant brain tumors. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">The phenomenological method for qualitative studies was adopted;convenience sampling was used to conduct semi-structured interviews to the mothers of 9 children with malignant brain tumors who received chemotherapy from June 2019 to December 2019;the Colaizzi 7-step analytical method was implemented to collate and analyze the original data. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The results were summarized into six subjects: stressed, exhausted because of trying to control everything </span><span style="font-family:Verdana;">in home care, prone to excessive care, financially burdened, desperate for</span><span style="font-family:Verdana;"> knowledge of patient care, and desperate for psychosocial support. </span><b><span style="font-family:Verdana;">Conclusions: </span></b><span style="font-family:Verdana;">Understanding the real experiences and inner feelings of mothers during</span><span style="font-family:Verdana;"> chemotherapy of their children with malignant brain tumors is helpful for medi</span><span style="font-family:Verdana;">cal staff to learn about the psychological distress and needs of mothers of</span><span style="font-family:Verdana;"> children with malignant brain tumors, so as to give them psychological support and even social support, and help the mothers and the families of children with malignant brain tumors get through a special period.</span></span></span></span> 展开更多
关键词 CHILDREN Brain Tumor MOTHER Negative Emotions Qualitative Study
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The emerging role of probiotics in neurodegenerative diseases:new hope for Parkinson’s disease? 认领
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作者 Vanessa Castelli Michele d’Angelo +3 位作者 Massimiliano Quintiliani Elisabetta Benedetti Maria Grazia Cifone Annamaria Cimini 《中国神经再生研究:英文版》 SCIE CAS CSCD 2021年第4期628-634,共7页
Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which... Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which is a bidirectional system between the central nervous system and the enteric nervous system.Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic,autoimmune,cancer,and,notably,neurodegenerative disorders.Diet can alter the microbiota composition,affecting the gutbrain axis function.Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions,including the use of probiotics.Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry,modulating different pathways.This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy,confirming that gut microbiota modulation influences different pro-survival pathways.Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary. 展开更多
关键词 age-related diseases brain DYSBIOSIS gut-brain axis MICROBIOTA NEURODEGENERATION NUTRACEUTICALS Parkinson’s disease PROBIOTICS SLAB51
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The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage 认领
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作者 Ning Sha Hua-Wei Wang +13 位作者 Bin Sun Min Gong Po Miao Xiao-Lu Jiang Xiao-Feng Yang Mei Li Li-Xiao Xu Chen-Xi Feng Yuan-Yuan Yang Jie Zhang Wen-Jing Zhu Yuan-Yuan Gao Xing Feng Xin Ding 《中国神经再生研究:英文版》 SCIE CAS CSCD 2021年第10期2071-2077,共7页
Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a r... Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm regulation.To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in 2019.We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD.Furthermore,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of miR-325.In addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland.We established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours.Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions.Finally,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3.Taken together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD.The clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,2015.Animal experiments were approved by Animal Care and Use Committee,School of Medicine 展开更多
关键词 brain injury circadian rhythm hypoxic-ischemic brain damage miRNA NEONATE pineal gland SLEEP transcription factor
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fMRI-based Decoding of Visual Information from Human Brain Activity: A Brief Review 认领
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作者 Shuo Huang Wei Shao Mei-Ling Wang 《国际自动化与计算杂志:英文版》 EI CSCD 2021年第2期170-184,共15页
One of the most significant challenges in the neuroscience community is to understand how the human brain works.Recent progress in neuroimaging techniques have validated that it is possible to decode a person′s thoug... One of the most significant challenges in the neuroscience community is to understand how the human brain works.Recent progress in neuroimaging techniques have validated that it is possible to decode a person′s thoughts,memories,and emotions via functional magnetic resonance imaging(i.e.,fMRI)since it can measure the neural activation of human brains with satisfied spatiotemporal resolutions.However,the unprecedented scale and complexity of the fMRI data have presented critical computational bottlenecks requiring new scientific analytic tools.Given the increasingly important role of machine learning in neuroscience,a great many machine learning algorithms are presented to analyze brain activities from the fMRI data.In this paper,we mainly provide a comprehensive and up-to-date review of machine learning methods for analyzing neural activities with the following three aspects,i.e.,brain image functional alignment,brain activity pattern analysis,and visual stimuli reconstruction.In addition,online resources and open research problems on brain pattern analysis are also provided for the convenience of future research. 展开更多
关键词 Functional magnetic resonance imaging(fMRI) functional alignment brain activity brain decoding visual stimuli reconstruction
Management and Prognostic Factors of Penetrating Craniocerebral Wounds at One Teaching Hospital in Benin 认领
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作者 Olatoundji Holden Fatigba Hamidath Bio Sika Yarou +4 位作者 Kisito Quenum Armel Hadonou Luphin Hodé Christian Padonou Alexandre Salako Allodé 《现代神经外科学进展(英文)》 2021年第1期34-48,共15页
<strong>Introduction.</strong> Penetrating craniocerebral wounds (PCCWs) are a particular lesion in the category of traumatic brain injury (TBI). The objective of this study was to describe the management ... <strong>Introduction.</strong> Penetrating craniocerebral wounds (PCCWs) are a particular lesion in the category of traumatic brain injury (TBI). The objective of this study was to describe the management of these lesions, and to identify signifiant risk factors associated with mortality in patients with a PCCW. <strong>Methods.</strong> It was a transversal, descriptive and analytical study performed in Departmental Teaching Hospital of Borgou and Alibori in Benin. From January 1, 2015 to June 30, 2020, patients with a PCCW were retained. Risk factors of mortality and morbidity associated to etiological, clinical and surgical parameters were assessed using the chi-square test. p value < 0.05 was considered to be statistically significant. <strong>Results.</strong> During the study period, 1267 cases of traumatic brain injuries (TBI) were admitted. Of these patients, 77 (6.1%) cases of PCCW were retained. These patients were divided into 66 (85.7%) male and 11 (14.3%) female. The mean age of the patients was 22.6 ± 14.8 years (range from 2 years to 70 years). The circumstances of occurrence were a traffic accident in 42 (54.5%) cases, an assault in 33 cases (42.9%) and a fall 2 (2.6%). The PCCW was unilateral in 71 cases (92.2%). A brain CT-scan was performed in 60 (77.9%) patients. Surgery was performed in 69 (89.6%) patients. Post-operative outcomes were simple in 59 (85.5%) cases. GCS, pupillary abnormalities, motor deficit were a statistically significant risk factor associated with death or sequels (p < 0.0001).<strong> Conclusion.</strong> The identification of risk factors of mortality or sequels is a major step for an efficient management of PCCWs and a reduction of morbidity and mortality. Whatever strategies are adopted, prevention must remain a priority. 展开更多
关键词 Traumatic Brain Injuries Craniocerebral Wounds Glasgow Coma Scale Risk Factors MORTALITY
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Neuropsychological and Social Outcome of Patients Sustaining Traumatic Brain Injury in Cotonou 认领
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作者 Hodé Luphin Fatigba O. Holden +1 位作者 Doningo P. S. Arsénathe Azanlin A. K. Nelly 《现代神经外科学进展(英文)》 2021年第1期49-58,共10页
This inaugural study in Benin was aimed at assessing neuropsychological and behavioural problems of patients with traumatic brain injury managed at the Hubert Koutoukou Maga Teaching hospital in Cotonou, and the impac... This inaugural study in Benin was aimed at assessing neuropsychological and behavioural problems of patients with traumatic brain injury managed at the Hubert Koutoukou Maga Teaching hospital in Cotonou, and the impact on their standard of leaving. This was a prospective and cross-cutting study with a descriptive and analytical aim. It was carried out from 1 July to 30 October 2018. The study population included patients over 15 years of age who had experienced TBI. A purposive sampling of 585 patients with TBI was done, of which 142 patients could not be reached by phone while. The mean age of patients was 37.16 ± 13.9 years, with extremes ranging from 16 to 87 years. The most frequent complaints were behavioural disorder (79.5%), headache (63.8%) and memory loss (50.4%). The average duration of post traumatic amnesia was 9.08 ± 38.56 days. Sixty-three patients (68.5%) had post-traumatic amnesia that lasted less than 30 minutes and 25 patients (19.2%) had post-traumatic amnesia that lasted over a month. Neuropsychological disorders were more frequent in patients with severe TBI. Attention disorders and difficulties in elaborating strategies were noticed without any statistically significant difference in mild, moderate as well as severe TBI. Nineteen patients lost their job, thus raising the unemployment rate in our sample from 6% to 21%. Among the 100 patients (75%) that recovered their job, 14% had medical follow-up and 10% returned to part-time work. Salary remained unchanged for 61.2% of TBI patients. 展开更多
关键词 Traumatic Brain Injury Neuropsychological Disorder Standard of Living Bénin
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Intrahepatic cholangiocarcinoma is more complex than we thought:A case report 认领
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作者 Jian-Ting Zeng Jie-Feng Zhang +5 位作者 Yu Wang Zhou Qing Zhen-Hua Luo Yan-Lin Zhang Yi Zhang Xian-ZhangLuo 《世界临床病例杂志》 SCIE 2021年第6期1469-1474,共6页
BACKGROUND Brain metastasis from intrahepatic cholangiocarcinoma is rare.To the best of our knowledge,only a few cases have been reported.The biological behavior was complex,and treatment requires further investigatio... BACKGROUND Brain metastasis from intrahepatic cholangiocarcinoma is rare.To the best of our knowledge,only a few cases have been reported.The biological behavior was complex,and treatment requires further investigation.CASE SUMMARY A 62-year-old woman complained of left limb weakness.Abdominal computed tomography showed a 5.0 cm×5.6 cm lesion in the left lobe of the liver.Tumor markers were normal.Serological analysis indicated absence of hepatitis virus.Brain magnetic resonance imaging revealed a 1.0 cm×1.3 cm mass in the right frontal lobe.Intrahepatic cholangiocarcinoma with brain metastasis was diagnosed by our liver cancer multidisciplinary team.After sufficient preparation,the patient underwent partial frontal lobotomy and left hemihepatectomy.Histopathological results confirmed that both the lesions were cholangiocarcinoma.Six cycles of gemcitabine combined with S1 were administered.During a 39 mo postoperative follow-up,no sign of local recurrence or distant metastasis was observed.CONCLUSION This case expands our knowledge concerning the complex and heterogeneous nature of tumor metastasis. 展开更多
关键词 Intrahepatic cholangiocarcinoma Brain metastasis Multidisciplinary team Synchronous brain metastasis Case report
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脑哲学的可能性与问题域 认领
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作者 肖峰 《科学技术哲学研究》 北大核心 2021年第1期1-8,共8页
脑是宇宙中最神奇的物质,是科学正在攻克的最艰难堡垒之一。脑科学的成就日新月异,在此背景下哲学也需要将脑纳入自己的视野,形成脑哲学这一新领域既有必要,也有可能。脑哲学与神经哲学、身体哲学、心智哲学等既有交叉,也有区别,具有独... 脑是宇宙中最神奇的物质,是科学正在攻克的最艰难堡垒之一。脑科学的成就日新月异,在此背景下哲学也需要将脑纳入自己的视野,形成脑哲学这一新领域既有必要,也有可能。脑哲学与神经哲学、身体哲学、心智哲学等既有交叉,也有区别,具有独立存在的价值和意义。脑哲学的重点问题是心脑关系问题,但也包含更广泛的其他问题,如脑的哲学界定问题、脑与人、脑与生命、脑与自我、脑与机器的关系问题等等。脑哲学所面临和探讨的新问题可以成为当代哲学探新的生长点。 展开更多
关键词 脑哲学 心智 人工智能
艾灸减轻新生小鼠缺氧缺血性脑病的作用及其机制研究 认领
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作者 欧阳昕 徐优慧 +1 位作者 陈明人 肖爱娇 《天津医药》 CAS 北大核心 2021年第3期248-252,I0003,共6页
目的研究艾灸减轻新生小鼠缺氧缺血性脑病(HIE)的作用及其机制。方法55只出生7 d的ICR小鼠按照随机数字表法分为假手术组(Sham组)、模型组(HI组)和艾灸组(MOX组)。HI组和MOX组采用右侧颈总动脉结扎联合缺氧法制备HIE模型,MOX组建模后艾... 目的研究艾灸减轻新生小鼠缺氧缺血性脑病(HIE)的作用及其机制。方法55只出生7 d的ICR小鼠按照随机数字表法分为假手术组(Sham组)、模型组(HI组)和艾灸组(MOX组)。HI组和MOX组采用右侧颈总动脉结扎联合缺氧法制备HIE模型,MOX组建模后艾灸刺激大椎穴,35 min/次,1次/d,连续治疗3 d。处理结束后麻醉取脑,DAPI染色观察脑组织形态结构,TUNEL染色检测脑组织细胞凋亡;免疫荧光染色检测脑组织caspase-9表达;放射免疫分析法测定脑组织caspase-3含量。结果与Sham组相比,HI组小鼠脑组织排列疏松,脑组织凋亡细胞数和caspase-9表达显著增多(P<0.05);与HI组相比,MOX组小鼠脑组织排列较致密,脑组织凋亡细胞数、caspase-9和caspase-3表达显著减少(P<0.05)。结论艾灸可能通过降低脑组织caspase-9和caspase-3的表达来减少细胞凋亡,从而减轻新生小鼠缺氧缺血性脑损伤。 展开更多
关键词 艾条灸 缺氧缺血 脑损伤 细胞凋亡 半胱氨酸天冬氨酸蛋白酶9 半胱氨酸天冬氨酸蛋白酶3 新生小鼠
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Environmental Risk of Atrazine (Herbicide) to Brain, Gills and Liver Tissues of Fish <i>Ctenopharyngodon idella</i>(Valenciennes, 1844) 认领
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作者 Waqar Ahmad Aamir Sultan +9 位作者 Sahibzada Muhammad Haseeb Jan Aamir Ali Ihtisham Ur Rahman Hazrat Usman Ahmad Sher Naqash Khan Suleman Zahid Khan Ahsan Khan 《地球科学和环境保护期刊(英文)》 2021年第2期1-16,共16页
The current study investigates the toxic effects of acute dose of an endocrine disruptor atrazine on Grass carp (<em>Ctenepharyngodon idella</em>) using histopathological changes as biomarkers. Histopathol... The current study investigates the toxic effects of acute dose of an endocrine disruptor atrazine on Grass carp (<em>Ctenepharyngodon idella</em>) using histopathological changes as biomarkers. Histopathology is promising field for research in aquatic toxicology, in this manner vital organs;brain, gills, and liver tissues were inspected histological after exposing to sublethal groupings of atrazine 0.025 and 0.03 μl/L for 3, 6, 9, 12 and 15 days individually with equal untreated control group. Against various doses, rapid movements, gulping of air and jumping of fish to scat from toxic medium were noticed. Various severe (+++) morphological modifications in tissue were documented in comparison with control group comprised of degenerated neurons, vacuolization, inflammatory cells infiltration and neural necrosis in brain tissue. The most well-known gills tissue alteration at all concentrations of atrazine was epithelial hyperplasia, desquamation, epithelial lifting and smaller aneurism while hepatic injuries were described by overcast expanding of hepatocytes esteemed as cloudy swelling of hepatocytes followed by karyolysis, karyohexis and dilation of sinusoids which shows that atrazine introduction upgraded the toxicosis impacts with the increase concentration, influenced the strength of the fish, inferable from histological inconsistencies. 展开更多
关键词 HISTOPATHOLOGICAL Toxicological BRAIN GILLS Liver
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GOECP/SEOR radiotherapy guidelines for small-cell lung cancer 认领
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作者 Felipe Couñago Carolina de la Pinta +10 位作者 Susana Gonzalo Castalia Fernández Piedad Almendros Patricia Calvo Begoña Taboada Antonio Gómez-Caamaño JoséLuis López Guerra Marisa Chust JoséAntonio GonzálezFerreira AnaÁlvarez González Francesc Casas 《世界临床肿瘤学杂志:英文版》 CAS 2021年第3期115-143,共29页
Small cell lung cancer(SCLC)accounts for approximately 20%of all lung cancers.The main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non... Small cell lung cancer(SCLC)accounts for approximately 20%of all lung cancers.The main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to Ch.Prophylactic cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic patients.The 5-year OS rate in patients with limited-stage disease(non-metastatic)is slightly higher than 30%,but less than 5%in patients with extensive-stage disease(metastatic).The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis,planning,and treatment of SCLC.These guidelines emphasise treatment fields,radiation techniques,fractionation,concomitant treatment,and the optimal timing of Ch and radiotherapy.Finally,we discuss the main indications for reirradiation in local recurrence. 展开更多
关键词 Small cell lung cancer Chemotherapy Hyperfractionated radiation therapy Prophylactic brain irradiation Brain metastases REIRRADIATION
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Atorvastatin combined with low-dose dexamethasone for vascular endothelial cell dysfunction induced by chronic subdural hematoma 认领
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作者 Yue-Shan Fan Bo Wang +8 位作者 Dong Wang Xin Xu Chuang Gao Ying Li Shu Zhang Gui-Li Yang Xiao Liu Rong-Cai Jiang Jian-Ning Zhang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2021年第3期523-530,共8页
Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural hematoma.However,treatment with atorvastatin is not effective in some patients,who must undergo f... Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural hematoma.However,treatment with atorvastatin is not effective in some patients,who must undergo further surgical treatment.Dexamethasone has anti-inflammatory and immunomodulatory effects,and low dosages are safe and effective for the treatment of many diseases,such as ankylosing spondylitis and community-acquired pneumonia.However,the effects of atorvastatin and low-dose dexamethasone for the treatment of chronic subdural hematoma remain poorly understood.Hematoma samples of patients with chronic subdural hematoma admitted to the General Hospital of Tianjin Medical University of China were collected and diluted in endothelial cell medium at 1:1 as the hematoma group.Atorvastatin,dexamethasone,or their combination was added to the culture medium.The main results were as follows:hopping probe ion conductance microscopy and permeability detection revealed that the best dosages to improve endothelial cell permeability were 0.1μM atorvastatin and 0.1μM dexamethasone.Atorvastatin,dexamethasone,or their combination could markedly improve the recovery of injured endothelial cells.Mice subcutaneously injected with diluted hematoma solution and then treated with atorvastatin,dexamethasone,or their combination exhibited varying levels of rescue of endothelial cell function.Hopping probe ion conductance microscopy,western blot assay,and polymerase chain reaction to evaluate the status of human cerebral endothelial cell status and expression level of tight junction protein indicated that atorvastatin,dexamethasone,or their combination could reduce subcutaneous vascular leakage caused by hematoma fluid.Moreover,the curative effect of the combined treatment was significantly better than that of either single treatment.Expression of Krüppel-like factor 2 protein in human cerebral endothelial cells was significantly increased,as was expression of the tight junction protein and vascular permeability marker va 展开更多
关键词 brain brain trauma cells central nervous system inflammation PLASTICITY protein repair
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