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阑尾炎手术患者围手术期预防性应用抗菌药物情况及合理性 认领

Situation and rationality of perioperative prophylactic use of antibiotics in patients with appendicitis surgery
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摘要 目的调查分析阑尾炎手术患者围手术期预防性应用抗菌药物情况,探讨其用药的合理性。方法随机选取2018年4月至2020年1月在我院实施手术治疗的106例阑尾炎患者作为研究对象。统计患者围手术期预防性应用抗菌药物的情况,并了解其用药时间及联合用药情况,分析用药合理性。结果106例阑尾炎手术患者中,97例为预防性用药,占比为91.51%。预防性用药患者所用药物中,头孢呋辛钠用药频率最高,占比为32.52%,其次为左氧氟沙星、甲硝唑、谷氨酸诺氟沙星及替硝唑。65.98%的患者预防性用药的时间为4~7 d。单独应用1种抗生素共计5例(5.15%),两种抗菌药物联合应用共计89例(91.75%),三种药物联合应用共计3例(3.09%)。206例次用药中,用药合理的共计128例次(62.14%),用药不合理的共计78例次(37.86%)。不合理用药的原因中,前五位分别为选药不当、用药时间过长、联合用药不当、剂量过大及用药时机不合理。结论我院阑尾炎手术患者围手术期预防性应用抗菌药物的比例较高,两种药物联合应用占比较高,大多数患者用药合理。围手术期预防性应用抗菌药物不合理的原因主要是选药不当、用药时间过长、联合用药不当等,临床医师需对这些问题加强关注,进一步提高抗菌药物合理用药水平。 Objective To investigate and analyze the perioperative prophylactic use of antibiotics in patients with appendicitis surgery,and to explore the rationality of the use of antibiotics.Methods A total of 106 patients with appendicitis who received surgery treatment in our hospital from April 2018 to January 2020 were randomly selected as the study objects.The perioperative prophylactic use of antibiotics was counted,the time and combination of drug use were understood,the rationality of drug use was analyzed.Results Among 106 patients with appendicitis surgery,97 cases with preventive medication,accounting for 91.51%.Among the drugs used by patients with preventive medication,the frequency of cefuroxime sodium was the highest,accounting for 32.52%,followed by levofloxacin,metronidazole,norfloxacin glutamate and tinidazole.There was 65.98%of the patients took 4-7 d of prophylactic medication.There were 5 cases(5.15%)treated with one antibiotic alone,89 cases(91.75%)combined with two kinds of antibiotics,and 3 cases(3.09%)combined with three kinds of antibiotics.Among 206 times of administration,128 times(62.14%)were rational and 78 times(37.86%)were irrational.The top five causes of irrational drug use were improper drug selection,long medication time,improper combination of drugs,excessive dosage and unreasonable timing of drug use.Conclusion In our hospital,the perioperative prophylactic use of antibiotics in patients with appendicitis surgery has higher proportion,the combined use of the two drugs has higher proportion,and use drugs of most patients reasonably.The main reasons for irrational use of perioperative prophylactic antibiotics are improper drug selection,long medication time and improper combination of drugs and so on,clinicians need to pay more attention to these problems,and further improve the level of rational use of antibiotics.
作者 李玉涛 LI Yutao(Shanzhou District People's Hospital,Sanmenxia 472000,China)
出处 《临床医学研究与实践》 2021年第1期91-93,共3页 Clinical Research and Practice
关键词 阑尾炎 围手术期 预防性应用抗菌药物 appendicitis perioperative period prophylactic use of antibiotics
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