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Neuroprotective mechanism of TMP269, a selective class ⅡA histone deacetylase inhibitor, after cerebral ischemia/reperfusion injury 预览
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作者 Lu Su Dan Liang +3 位作者 Shen-Yi Kuang Qiang Dong Xiang Han Zheng Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期277-284,共8页
TMP269 is a selective class ⅡA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of ... TMP269 is a selective class ⅡA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of TMP269 for protecting against cerebral ischemia/reperfusion injury and its neuroprotective mechanism. Male Sprague-Dawley rats were randomly divided into sham, ischemia/reperfusion, and 1, 4, 10 and 16 mg/kg TMP269 groups. Cerebral ischemia/reperfusion injury was induced by middle cerebral artery occlusion. TMP269 was intraperitoneally administered at different doses 0.5 hours before ischemia induction. Western blot assay and immunohistochemistry were used to detect effects of TMP269 on histone 2 acetylation. The results showed that the level of histone 2 acetylation was increased 24 hours after TMP269 injection. 2,3,5-Triphenyltetrazolium chloride staining was utilized to examine effect of TMP269 on infarct volume. The results found that different doses of TMP269 could reduce the infarct volume. Western blot assay, immunohistochemistry and Evans blue staining were employed to measure the effect of TMP269 on blood-brain barrier. The results showed that TMP269 counteracted the abnormal endothelial cell permeability changes caused by cerebral ischemia/reperfusion. Western blot assay and immunohistochemistry were used to determine the effect of TMP269 on tissue kallikrein. The results found that TMP269 up-regulated the expression of tissue kallikrein. Western blot assay further determined the optimal concentration to be 4 mg/kg. In conclusion, TMP269 plays a neuroprotective role by up-regulating the level of histone 2 acetylation, alleviating endothelial cell injury after cerebral ischemia/reperfusion, and up-regulating the expression of tissue kallikrein. The experimental protocol was approved in 2014 by the Department of Laboratory Animal Science, Fudan University, China(approval No. 20140143 C001). 展开更多
关键词 blood-brain barrier drug treatment endothelial cell permeability HISTONE DEACETYLASE inhibitor NEUROPROTECTION stroke tissue KALLIKREIN TMP269
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Combining fatty acid amide hydrolase(FAAH)inhibition with peroxisome proliferator-activated receptor(PPAR)activation:a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 预览
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作者 Leonardo Brunetti Antonio Laghezza +2 位作者 Fulvio Loiodice Paolo Tortorella Luca Piemontese 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期67-68,共2页
Alzheimer’s disease(AD)is a widespread pathology described for the first time by Alois Alzheimer in 1907.It can be classified as a neurodegenerative disease consisting in a progressive loss of memory and cognitive fu... Alzheimer’s disease(AD)is a widespread pathology described for the first time by Alois Alzheimer in 1907.It can be classified as a neurodegenerative disease consisting in a progressive loss of memory and cognitive functions,whose prevalence is estimated to grow due to the increasing life expectancies all over the world.To date,the only treatments available for this disease are symptomatic and no actual effective cure is available.The main effect of the drugs commonly used in therapeutic protocols is to temporarily delay the onset of the disease and to slightly improve the patients’cognitive capabilities(Piemontese,2017)(Figure 1). 展开更多
关键词 ALZHEIMER drugs TREATMENT
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Remote ischemic conditioning approach for the treatment of ischemic stroke 预览
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作者 Seyed Mohammad Seyedsaadat David F.Kallmes Waleed Brinjikji 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1033-1034,共2页
Stroke is the leading cause of disability and death in North America.There has been growing interest in identifying neuroprotective strategies to reduce ischemic burden in patients with acute ischemic stroke.However,d... Stroke is the leading cause of disability and death in North America.There has been growing interest in identifying neuroprotective strategies to reduce ischemic burden in patients with acute ischemic stroke.However,despite extensive clinical trials,no neuroprotective agent has been found for prevention of ischemic damage.Remote ischemic preconditioning(RIC)is a promising non-invasive strategy that has been proven to provide renal and cardioprotection and has recently found to have a potential broad application in the treatment of neurovascular disease,which has bee linked to its possible effects on the release and activation of endogenous neuroprotective substances against the ischemia/reperfusion injuries in experimental studies.This endogenous neuroprotection might vaccinate neural tissues against effects of acute IR following primary infarction insult.Regardless of the method of RIC administration,through manual or automated blood pressure cuff,RIC procedure is inexpensive and easy to use.Based on the experimental and clinical data,application of RIC avoids possible adverse effects and interactions associated with chemical pharmacological agents.In previous clinical studies RIC was safe and associated with only minor transient adverse effects in few cases,including petechia and minor limb pain,which were mostly resolved shortly after completing the treatment. 展开更多
关键词 PREVENTION TREATMENT REMOTE
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Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance 预览
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作者 Fang Xing Xin Fang +5 位作者 Xiang-Dan Gong Xin Zhao Ying Du Zheng-Liang Ma Xiao-Ping Gu Tian-Jiao Xia 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1094-1101,共8页
Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive dysfunction.Photoacoustic treatments including light and sound stimulation have been found to b... Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive dysfunction.Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pattern experiments.In this study,we examined whether light and sound interventions could reduce sleep-wake pattern disturbances and memory deficits in a sleep rhythm disturbance model.We established a model of sleep rhythm disturbance in C57 BL/6 J mice via a sleep deprivation method involving manual cage tapping,cage jostling,and nest disturbance.We used a Mini Mitter radio transmitter device to monitor motor activity in the mice and fear conditioning tests to assess cognitive function.Our results indicated that an intervention in which the mice were exposed to blue light(40-Hz flickering frequency)for 1 hour during their subjective daytime significantly improved the 24-hour-acrophase shift and reduced the degree of memory deficit induced by sleep deprivation.However,interventions in which the mice were exposed to a 40-Hz blue light at offset time or subjective night time points,as well as 2 Hz-blue light at 3 intervention time points(subjective day time,subjective night time,and offset time points),had no positive effects on circadian rhythm shift or memory deficits.Additionally,a 2000-Hz sound intervention during subjective day time attenuated the24-hour-acrophase shift and memory decline,while 440-Hz and 4000-Hz sounds had no effect on circadian rhythms.Overall,these results demonstrate that photoacoustic treatment effectively corrected abnormal sleep-wake patterns and cognitive dysfunction associated with sleep-deprivation-induced disturbances in sleep-wake rhythm.All animal experiments were approved by the Experimental Animal Ethics Committee of Drum Tower Hospital Affiliated to the Medical College of Nanjing University,China(approval No.20171102)on November20,2017. 展开更多
关键词 circadian rhythm cognitive impairment fear conditioning light intervention photoacoustic treatment rhythm disturbance rhythm shift sleep deprivation sleep-wake rhythm sound intervention
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Operative managements of extracranial carotid artery aneurysms: a report of three cases and literature review
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作者 Maimaitituersun Abudula Aximujiang Axier +5 位作者 Kaheerman Kadeer Xiaojiang Cheng Taotao Dou Atawula Tuersun Mierzati Tuerhong Maimaitili Aisha 《中华神经外科杂志(英文)》 CSCD 2019年第2期115-120,共6页
Background:The purpose of this study is to report the treatment approaches and postoperative outcomes of extracranial carotid artery aneurysms (ECAAs) and discuss the symptoms,related risk factors,etiology,diagnostic ... Background:The purpose of this study is to report the treatment approaches and postoperative outcomes of extracranial carotid artery aneurysms (ECAAs) and discuss the symptoms,related risk factors,etiology,diagnostic methods,treatments,and follow-up period complications.Case presentation:We describe three patients with symptomatic extracranial carotid artery aneurysms;one of them was treated with end-to-end anastomosis of the extracranial internal carotid artery (EICA) after the resection of the aneurysm,while the other two patients were deployed with Willis covered stents in the extracranial internal carotid artery.All of the patients were in good condition when discharged home.After a mean follow-up period of 8 months,all the patients were alive and only one of them had the neurologic deficit.Additionally,we reviewed the relative literatures.Conclusion:Both of the surgical and endovascular treatments have relatively satisfactory outcomes in ECAA patients.However,it is necessary to provide individualized treatments to different patients according to the characteristics of the aneurysms. 展开更多
关键词 EXTRACRANIAL CAROTID artery ANEURYSM ENDOVASCULAR TREATMENT Surgical TREATMENT WILLIS covered stent
Source,Process and End Treatment Technology of Volatile Organic Compounds in Oil Storage 预览
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作者 Yuan Yuan Chen Tingting +1 位作者 Zhao Fengjie Sun Hui 《气象与环境研究:英文版》 CAS 2019年第2期83-90,共8页
Oil storage is a source of volatile organic compounds( VOCs). Volatile organic compounds can cause different damages to the environment,animals and plants. Therefore, it is important to control the discharge of VOCs i... Oil storage is a source of volatile organic compounds( VOCs). Volatile organic compounds can cause different damages to the environment,animals and plants. Therefore, it is important to control the discharge of VOCs in oil storage. In this paper,the control technology of sources of VOCs pollution in oil storage was analyzed from the source,process and end treatment,and measures for the prevention and control of VOCs pollution in oil storage were proposed. 展开更多
关键词 OIL STORAGE VOLATILE organic compounds Whole process TREATMENT TREATMENT TECHNOLOGY
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Treatment of Traumatic Acetabulum Lesions in an African Orthopaedic Trauma Department 预览
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作者 S. C. Da S. A. Korsaga +7 位作者 Aji Ouedraogo C. Darga H. Kafando M. O. Somé S. Tinto D. Denné L. Ouédraogo M. Sawadogo 《矫形学期刊(英文)》 2019年第10期197-211,共15页
Background: The management of traumatic acetabular injuries (TAI), which are often complex and diverse, is difficult and costly in the context of low-income African countries. Objective: To evaluate the treatment of t... Background: The management of traumatic acetabular injuries (TAI), which are often complex and diverse, is difficult and costly in the context of low-income African countries. Objective: To evaluate the treatment of traumatic acetabular lesions in the Orthopedics and Traumatology Department of the Yalgado Ouedraogo University Hospital, for their better management. Patients and Methods: This was a retrospective study, conducted in our department from January 2012 to December 2016. Sixty-three patients with TAI and complete records were selected. The mean age of patients with coxofemoral dislocations was 34.2 years and 36.4 years for acetabulum fractures with male predominance in both injury types. The injuries were mainly caused by a violent road traffic accident (RTA) (90.5%). Forty hip dislocations and 41 acetabular fractures were reported, with a prevalence of iliac dislocations (52.5%) and posterior wall fractures of the acetabulum (24.4%). Results: The average time to manage TAI was 15.9 hours (range 2 - 100). Medical treatment was performed in all patients. Thirty-eight coxofemoral dislocations and 34 acetabular fractures were treated by orthopedic methods. Seven complex acetabular fractures and two coxo-femoral dislocations were performed by surgical method. Two patients died (3.2%), one in a hemorrhagic shock table and the other in a septic shock table. Immediate and late complications were identified. Conclusion: Early and adequate management of our TAI, requires a modern technical platform and a sufficient number of qualified medical personnel to improve their functional outcomes. 展开更多
关键词 Hip ACETABULUM DISLOCATION Fracture TREATMENT
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Pediatric Traumatic Brain Injury Pattern at the General Hospital, Douala, Cameroon 预览
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作者 Aurélien Ndoumbe Mathieu Motah +1 位作者 Angéline Rolande Assomo Dah Mireille Moumi 《现代神经外科学进展(英文)》 2019年第1期49-60,共12页
Traumatic brain injury is the most common injury during childhood comprising 60% to 90% injuries in children. Pediatric traumatic brain injury has peculiarities as compared to adults, such as less severe injuries and ... Traumatic brain injury is the most common injury during childhood comprising 60% to 90% injuries in children. Pediatric traumatic brain injury has peculiarities as compared to adults, such as less severe injuries and better prognosis. The purpose of this work was to study the pattern of pediatric traumatic brain injury at the General Hospital, Douala, Cameroon. This was a retrospective cross-sectional study, from January 1st, 2008 to December 31st, 2017. Included were all complete medical records of children aged 0 to 15 years old treated for traumatic brain injury, and excluded records of obstetric trauma. Data analysis was done by SPSS software version 18.0. One hundred and three cases of pediatric head injuries were recorded during the study period (frequency 10.43%). The mean age was 7.42 ± 5.028 years, and the sex ratio was 2.67 in favor of boys. Road traffic accidents were the most common etiology (44.7%). 83.5% of the patients were transferred to the emergency department of the Douala General Hospital in second intention and by non-medical transport. The traumatic brain injury was mild in 61.20%. The brain computed tomography scan was performed in 99% of the cases and the most observed lesion was cerebral edema (32.74%). Twenty-eight patients underwent surgical operation. 90.28% of patients have recovered fully, and the global mortality was 3.88%. The prevalence of pediatric traumatic brain injuries at the General Hospital, Douala during the last ten years was 10.43%. Most of the patients recovered fully and the mortality was low. 展开更多
关键词 TRAUMATIC Brain Injury PEDIATRICS COMPUTED TOMOGRAPHY SCANNING Treatment OUTCOME
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Management of Traumatic Injuries of Road Traffic Accident Victims in the City of Ouagadougou at the University Hospital Trauma Emergency Department-Yalgado Ouédraogo 预览
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作者 Alexandre S. Korsaga Anatole J. I. Ouedraogo +6 位作者 Sayouba Tinto Ives R. Kieno Mamoudou Sawadogo M. Narcisse Dabire Mohamed Tall Namori Keita Songahir C. Da 《矫形学期刊(英文)》 2019年第10期212-223,共12页
Purpose: To evaluate the management of traumatic injuries of accident victims in the city of Ouagadougou admitted to the trauma emergencies of the University Hospital of Ouagadougou. Material and Method: This was a de... Purpose: To evaluate the management of traumatic injuries of accident victims in the city of Ouagadougou admitted to the trauma emergencies of the University Hospital of Ouagadougou. Material and Method: This was a descriptive prospective study of road traffic accident victims in the city of Ouagadougou on their arrival at trauma emergencies and on the 7th and 30th day after their discharge. A total of 991 patients were identified. The sex ratio was 1.94 with a male predominance. The average age of the patients was 31.5 years. The ratio of caregivers to patients on a 24-hour shift was 7/47, excluding patients hospitalized in the corridors. Results: We note that 81.94% of patients were transported by the fire brigade. The average time to first contact with a caregiver was 11 minutes. Upon admission, accident victims were accompanied in 84% of cases. The combination of paracetamol and néfopam was the most prescribed analgesic (50.2%). The average time between admission and X-ray completion was 101 minutes. Benign skin lesions were the most frequent (48.82%), followed by osteoarticular lesions of the limbs (fractures and dislocations). Ceftriaxone, and the combination of Amoxicillin + Clavulanic Acid, were the most prescribed antibiotics. Dressings and sutures (44.63%) were the most commonly performed treatments, followed by orthopaedic restraints (37.88%) and open fracture areas in 14.34%. The average time between admission and orthopaedic and/or surgical treatment was 04 hours 25 minutes. Patients discharged against medical advice accounted for 10.80% of cases. In 95% of cases, patients were satisfied with their management. Conclusion: The management of patients admitted to trauma emergencies is satisfactory, but difficulties remain in terms of delays in management. It is imperative to take into account certain factors involving both staff and working conditions in order to reduce the time required to provide care and improve user satisfaction in this emergency unit. 展开更多
关键词 EMERGENCIES TRAUMA Treatment SATISFACTION
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吡啶废水常用处理方法研究进展 预览
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作者 梁希伦 傅梦凯 刘锐 《广东化工》 CAS 2019年第4期140-141,共2页
针对吡啶废水的多种处理方法,本文介绍了物理法、化学法、生物法的处理方法,对废水处理方法,进行了简单总结,以及在工程实际应用中的不足,对吡啶废水处理未来研究方向进行展望。
关键词 吡啶 处理方法 废水处理
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中医药治疗小儿癫痫研究进展 预览
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作者 刘驰 刘瑶 史正刚 《中医药临床杂志》 2019年第9期1769-1772,共4页
癫痫是由多种原因引起的一种脑部慢性疾患,中医药治疗癫痫疗效显著、不良反应少。该文从小儿癫痫的病因病机、辨证论治(内治法、外治法)两个方面总结近5年来中医药治疗小儿癫痫的研究进展。大量文献研究认为中医药治疗癫痫形成了汤剂口... 癫痫是由多种原因引起的一种脑部慢性疾患,中医药治疗癫痫疗效显著、不良反应少。该文从小儿癫痫的病因病机、辨证论治(内治法、外治法)两个方面总结近5年来中医药治疗小儿癫痫的研究进展。大量文献研究认为中医药治疗癫痫形成了汤剂口服内治法及针灸、推拿中医外治法等多种有效治疗方法,临床疗效显著,在控制癫痫发作,改善远期预后方面均有显著优势。 展开更多
关键词 癫痫 中医药 内治法 外治法 研究进展
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手术在局部晚期喉咽鳞状细胞癌综合治疗中的应用 预览
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作者 张欣睿 陈晓琦 +4 位作者 谭国杰 周毅波 赵政 吴迪 刘学奎 《中国耳鼻咽喉颅底外科杂志》 CAS 2019年第4期361-366,共6页
目的评价手术联合诱导化疗+同步放/化疗对于改善局部晚期喉咽鳞状细胞癌总体预后的价值。方法回顾性分析中山大学肿瘤防治中心2003年6月~2015年12月收治的122例Ⅲ~Ⅳ期喉咽鳞状细胞癌临床资料,入组患者均接受2程诱导化疗,根据后续治疗... 目的评价手术联合诱导化疗+同步放/化疗对于改善局部晚期喉咽鳞状细胞癌总体预后的价值。方法回顾性分析中山大学肿瘤防治中心2003年6月~2015年12月收治的122例Ⅲ~Ⅳ期喉咽鳞状细胞癌临床资料,入组患者均接受2程诱导化疗,根据后续治疗将患者分为手术组(62例,手术+同步放/化疗)和非手术组(60例,同步放/化疗),比较两组患者的临床病理参数、疗效差异及预后的影响因素。采用SPSS 22.0统计软件对所有数据进行分析。结果入组患者中手术组62例,死亡45例;非手术组60例,死亡38例。单因素分析示:分化程度、肿瘤临床分期Ⅲ/Ⅳ期和是否颈淋巴结转移(P<0.05)是影响患者预后生存的独立因素;多因素分析示:分化程度(P=0.010)、肿瘤临床分期Ⅲ/Ⅳ期(P=0.044)是影响患者预后生存的重要因素。分层分析诱导化疗有效组,手术组患者3年和5年总生存率(overall survival,OS)为93.2%和86.0%,非手术组患者的3年和5年OS分别为74.3%和60.2%,两组之间差异具有统计学意义(χ~2=5.274,P=0.022)。结论对于局部晚期喉咽鳞癌患者,诱导化疗+手术+同步放/化疗的综合治疗模式虽然不能有效提高患者总生存率和无瘤生存率,但对诱导化疗有效者显示了良好的疗效及安全性,可能从手术治疗中获益。 展开更多
关键词 喉咽癌 鳞状细胞癌 手术 非手术 放/化疗
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Dealumination and desilication for Al-rich HZSM-5 zeolite via steam-alkaline treatment and its application in methanol aromatization
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作者 Yuehua Fang Fan Yang +1 位作者 Xuan He Xuedong Zhu 《化学科学与工程前沿:英文版》 EI CAS CSCD 2019年第3期543-553,共11页
The hierarchical HZSM-5 was prepared via dealumination and desilication of commercial Al-rich HZSM-5, and characterized by X-ray diffraction, 27Al magic-angle spinning nuclear magnetic resonance, inductively coupled p... The hierarchical HZSM-5 was prepared via dealumination and desilication of commercial Al-rich HZSM-5, and characterized by X-ray diffraction, 27Al magic-angle spinning nuclear magnetic resonance, inductively coupled plasma mass spectrometry, scanning electron microscope, transmission electron microscope, N2 adsorption-desorption, NH3 temperature-programmed desorption, performed thermogravimetric and Raman spectrum. The results showed that partial framework of HZSM-5 was removed after steam treatment at 0.15 MPa, 500℃ for 3 h. HZSM-5 with high specific surface area and much mesoporosity was obtained by the subsequent alkaline treatment. The regulation of acid quantity was achieved by altering the concentration of alkaline. Dealumination and desilication of Al-rich HZSM-5 zeolites became more effective using a combination of steam and alkaline treatments than using alkaline treatment alone. Methanol aromatization reaction was employed to evaluate the catalytic performance of treated HZSM-5 at 0.15 MPa, 450℃ and MHSV of 1.5 h^-1. The results indicated that after steam treatment, HZSM-5 further treated with 0.2 mol/L NaOH exhibits the best catalytic performance: the selectivity of aromatics reached 42.1% and the lifetime of catalyst attained 212 h, which are much better than untreated HZSM-5. 展开更多
关键词 STEAM TREATMENT alkaline treatment hierarchical ZSM-5 METHANOL AROMATIZATION
胎头旋转法治疗枕后位难产的临床效果分析 预览
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作者 李春红 《世界复合医学》 2019年第8期81-83,共3页
目的探究胎头旋转法治疗枕后位难产的临床疗效。方法选择2017年1月—2018年1月该院确诊的80例枕后位难产产妇作为研究对象,采用数字随机法分为对照组、观察组,对照组产妇给予常规治疗,观察组产妇给予胎头旋转法治疗,对比两组产妇顺产率... 目的探究胎头旋转法治疗枕后位难产的临床疗效。方法选择2017年1月—2018年1月该院确诊的80例枕后位难产产妇作为研究对象,采用数字随机法分为对照组、观察组,对照组产妇给予常规治疗,观察组产妇给予胎头旋转法治疗,对比两组产妇顺产率、剖宫产率、新生儿Apgar评分以及治疗满意度。结果观察组产妇顺产率为82.50%,高于对照组的60.00%,差异明显(χ^2=4.943,P<0.05);观察组剖宫产率、产后出血量分别为17.50%、(221.75±20.44)mL,均低于对照组的40.00%、(423.48±31.12)mL,差异有统计学意义(χ^2=4.943,t=34.267,P<0.05);观察组新生儿Apgar评分为(8.39±1.52)分,明显高于对照组的(7.42±1.05)分,组间数据对比结果显示:差异有统计学意义(t=3.321,P<0.05)。结论胎头旋转法治疗枕后位难产效果显著。 展开更多
关键词 胎头旋转法 治疗 枕后位 难产 临床疗效 治疗满意度
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Assessment of Cadmium and Lead in Dried Sewage Sludge from Lubigi Feacal Sludge and Wastewater Treatment Plant in Uganda 预览
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作者 Juliet Kyayesimira Abbey Ssemaganda +1 位作者 Godfrey Muhwezi Morgan Andama 《水资源与保护(英文)》 2019年第6期690-699,共10页
Sludge contains organic and inorganic compounds including traces of heavy metals such as lead (Pb), cadmium (Cd), copper (Cu), nickel (Ni), chromium (Cr) and others. These metals restrict the use of sludge in agricult... Sludge contains organic and inorganic compounds including traces of heavy metals such as lead (Pb), cadmium (Cd), copper (Cu), nickel (Ni), chromium (Cr) and others. These metals restrict the use of sludge in agriculture because their accumulation is harmful to the environment and particularly the food chain. Cadmium and lead are among the most common heavy metals found in municipal wastewater treatment plant sludge. They are capable of bioaccumulation in plant tissues like roots and leaves and are non-biodegradable and therefore they remain in the sludge which is disposed on land or used as fertilizers on farms. The presence of heavy metal pollutants serves as a great threat to soils and also makes plants grown on such soils unfit for animal and human consumption as they may have detrimental effects to animal and human life. For instance, Pb and Cd are known to be human carcinogens. This study therefore aimed to investigate the levels of Cd and Pb in the treated dry sludge from Lubigi Feacal Sludge and Wastewater treatment plant located in Kawempe division, Kampala city, Uganda so as to ascertain its safety for use on agricultural lands. Two batches of samples were collected and analyzed at Government Analytical laboratory in Wandegeya, Uganda. The acid digested sludge samples were analyzed using Atomic Absorption Spectroscopy (AAS) method. The average concentrations of Pb found in collected sludge samples, batch 1 (11.912 mg/kg dm) and batch 2 (5.304 mg/kg dm) were far below the Environment Protection Agency (EPA) maximum permissible concentration (840 mg/kg) for any land application. Cadmium was not detected in all the sludge samples collected;there is an implication that it is either completely absent in the sludge generated by the plant or present but far below detectable levels. The sludge generated from Lubigi fecal sludge and wastewater treatment plant is therefore safe for application on agricultural lands as far as Pb and Cd concentrations are concerned. 展开更多
关键词 LEAD CADMIUM SLUDGE WASTEWATER Treatment Uganda
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颅内动脉瘤性蛛网膜下腔出血不同时机开颅手术与血管内治疗的疗效以及预后因素研究 预览
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作者 聂文臣 《系统医学》 2019年第20期95-97,共3页
目的研究不相同时机开颅手术、血管内治疗对于颅内动脉瘤性蛛网膜下腔出血患者的作用与效果。方法选出该院依据Hunt-Hess分级法在2016年11月-2019年2月的25例颅内动脉瘤性蛛网膜下腔出血患者,将其作为低分级组,另选出在此基础之上的25... 目的研究不相同时机开颅手术、血管内治疗对于颅内动脉瘤性蛛网膜下腔出血患者的作用与效果。方法选出该院依据Hunt-Hess分级法在2016年11月-2019年2月的25例颅内动脉瘤性蛛网膜下腔出血患者,将其作为低分级组,另选出在此基础之上的25例颅内动脉瘤性蛛网膜下腔出血患者,将其作为高分级组,对所有患者都运用早期与延期、血管内治疗与开颅手术,观察比较其结果。结果对于低分级组而言,两类手术在早期实施治疗其效果90.91%、85.71%优于延期33.33%、25.00%,差异有统计学意义(χ^2=4.641、4.055,P=0.031、0.044<0.05);对于高分级组而言,延期进行治疗其效果90.91%、85.71%优于早期33.33%、25.00%,差异有统计学意义(χ^2=4.641、4.055,P=0.031、0.044<0.05)。结论对于颅内动脉瘤性蛛网膜下腔出血患者,其治疗与手术时机间具有关联性,与手术方法间没有关联性。 展开更多
关键词 开颅手术 治疗 颅内动脉瘤性蛛网膜下腔出血 效果 血管内治疗
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Analysis of the Causes of Chronic Pain after Inguinal Hernia Repair without Tension and Its Prevention and Treatment 预览
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作者 Hao Wu Weimin Li 《临床医学国际期刊(英文)》 2019年第3期122-127,共6页
Purpose: Analyzing the causes of pain after tension-free repair in the inguinal hernia, and propose corresponding treatment strategies. Results: The patients in this group were followed up for 3 - 12 months. A total o... Purpose: Analyzing the causes of pain after tension-free repair in the inguinal hernia, and propose corresponding treatment strategies. Results: The patients in this group were followed up for 3 - 12 months. A total of 5 patients still had pain relief within 3 months after surgery. Further treatment was needed, and the incidence rate was 5%. Conclusion: Skilled surgical procedures are performed in patients with local anesthesia, and some of the absorbable repair materials can be used. The improved patch fixation and extra peritoneal repair can reduce the pain after inguinal hernia repair without tension. 展开更多
关键词 INGUINAL HERNIA TENSION-FREE HERNIA Repair Chronic PAIN The REASON Treatment
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Chinese expert consensus statement on the diagnosis and treatment of fulminant myocarditis
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作者 Daowen Wang Sheng Li +12 位作者 Jiangang Jiang Jiangtao Yan Chunxia Zhao Yan Wang Yexin Ma Hesong Zeng Xiaomei Guo Hong Wang Jiarong Tang Houjuan Zuo Li Lin Guanglin Cui Section of Precision Medicine Group of Chinese Society of Cardiology,Editorial Board of Chinese Journal of Cardiology &Working Group of Adult Fulminant Myocarditis 《中国科学:生命科学英文版》 SCIE CAS CSCD 2019年第2期187-202,共16页
Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-on... Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock,with mortality rates as high as 50%–70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Here, we provide the first expert consensus, the Chinese Society of Cardiology Expert Consensus Statement on the Diagnosis and Treatment of Fulminant Myocarditis, based on data from our recent clinical trial(NCT03268642). In this statement, we describe the clinical features and diagnostic criteria of fulminant myocarditis, and importantly, for the first time,we describe a new treatment regimen termed life support-based comprehensive treatment regimen. The core content of this treatment regimen includes(i) mechanical life support(applications of mechanical respirators and circulatory support systems,including intraaortic balloon pump and extracorporeal membrane oxygenation),(ii) immunological modulation by using sufficient doses of glucocorticoid, immunoglobulin and(iii) antiviral reagents using neuraminidase inhibitor. The proper application of this treatment regimen may and has helped to save the lives of many patients with fulminant myocarditis. 展开更多
关键词 adult FULMINANT MYOCARDITIS diagnosis and TREATMENT EXPERT consensus life support-based comprehensive TREATMENT regimen CARDIOGENIC shock mechanical circulatory SUPPORT
论中风病因病机理论及其层级划分 预览
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作者 张惜燕 邢玉瑞 《山东中医杂志》 2019年第5期418-421,共4页
以中风病因病机相关文献为基础,将现有理论按照病因(外因、内因、基础病因)、病机(基本病机、分期病机、分病病机、证候病机)进行层级划分,探讨其理论内涵,明确其各自在中风发生发展中的作用和地位,为下一步治法层级的整理提供理论依据... 以中风病因病机相关文献为基础,将现有理论按照病因(外因、内因、基础病因)、病机(基本病机、分期病机、分病病机、证候病机)进行层级划分,探讨其理论内涵,明确其各自在中风发生发展中的作用和地位,为下一步治法层级的整理提供理论依据,以期形成系统性、逻辑性的中医中风'因机证治'诊疗体系。 展开更多
关键词 中风 病因 病机 治法 层级划分 诊疗体系
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钛板颅骨修补术后并发症的处理及防治 预览
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作者 张涛 陈志儒 李江华 《中国继续医学教育》 2019年第1期82-83,共2页
目的探讨钛板颅骨修补术后并发症的处理及防治。方法选取我院2014年1月—2015年1月收治的80例颅骨缺损患者为研究对象,均行头颅CT薄层扫描,然后进行三维重建,再将数据传送到计算机辅助设计,待数字成型后,制作成与患者颅骨缺损大小相仿... 目的探讨钛板颅骨修补术后并发症的处理及防治。方法选取我院2014年1月—2015年1月收治的80例颅骨缺损患者为研究对象,均行头颅CT薄层扫描,然后进行三维重建,再将数据传送到计算机辅助设计,待数字成型后,制作成与患者颅骨缺损大小相仿的钛板,进行颅骨修补手术。结果本组80例患者整体修复美观,没有明显的不对称,在6个月~3年的随访期内,仅有9例(11.25%)患者发生并发症,经积极治疗后治愈。结论钛板颅骨修补术修补效果良好,并发症发生率低,但并发症可能会导致手术失败,所以应采取积极有效的措施进行处理,提高手术成功率。 展开更多
关键词 钛板 颅骨修补 并发症 处理 防治 神经外科
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