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Peritoneal macrophages attenuate retinal ganglion cell survival and neurite outgrowth 认领
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作者 Jia-Jian Liang Yu-Fen Liu +4 位作者 Tsz Kin Ng Ci-Yan Xu Mingzhi Zhang Chi Pui Pang Ling-Ping Cen 《中国神经再生研究:英文版》 SCIE CAS 2021年第6期1121-1126,共6页
Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or injury.However,the effects and mechanisms of macrophage activation on neuronal surv... Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or injury.However,the effects and mechanisms of macrophage activation on neuronal survival remain unclear.In the present study,we co-cultured adult Fischer rat retinas with primary peritoneal macrophages or zymosan-treated peritoneal macrophages for 7 days.Immunofluorescence analysis revealed that peritoneal macrophages reduced retinal ganglion cell survival and neurite outgrowth in the retinal explant compared with the control group.The addition of zymosan to peritoneal macrophages attenuated the survival and neurite outgrowth of retinal ganglion cells.Conditioned media from peritoneal macrophages also reduced retinal ganglion cell survival and neurite outgrowth.This result suggests that secretions from peritoneal macrophages mediate the inhibitory effects of these macrophages.In addition,increased inflammationand oxidation-related gene expression may be related to the enhanced retinal ganglion cell degeneration caused by zymosan activation.In summary,this study revealed that primary rat peritoneal macrophages attenuated retinal ganglion cell survival and neurite outgrowth,and that macrophage activation further aggravated retinal ganglion cell degeneration.This study was approved by the Animal Ethics Committee of the Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong,Shantou,Guangdong Province,China,on March 11,2014(approval no.EC20140311(2)-P01). 展开更多
关键词 in vitro INFLAMMATION MACROPHAGES MODEL neurite outgrowth optic nerve retinal ganglion cells SURVIVAL
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Creatine kinase in the diagnosis and prognostic prediction of amyotrophic lateral sclerosis:a retrospective case-control study 认领
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作者 Xue-Ping Chen Qian-Qian Wei +8 位作者 Ru-Wei Ou Yan-Bing Hou Ling-Yu Zhang Xiao-Qin Yuan Yun-Qian Yao De-Sheng Jia Qian Zhang Wei-Xue Li Hui-Fang Shang 《中国神经再生研究:英文版》 SCIE CAS 2021年第3期591-595,共5页
Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis.In the present retrospective case-control study,we included 582 pa... Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis.In the present retrospective case-control study,we included 582 patients with amyotrophic lateral sclerosis and 582 age-and sexmatched healthy controls.All amyotrophic lateral sclerosis participants received treatment in the Department of Neurology,West China Hospital,China,between May 2008 and December 2018.Serum creatine kinase levels in patients with amyotrophic lateral sclerosis were significantly higher than those in healthy controls.Subgroup analysis revealed that serum creatine kinase levels in men were higher than those in women in both amyotrophic lateral sclerosis patients and healthy controls.Compared with patients with bulbar-onset amyotrophic lateral sclerosis,patients with limb-onset amyotrophic lateral sclerosis had higher creatine kinase levels.Spearman's correlation analysis revealed that serum creatine kinase levels were not correlated with body mass index,Amyotrophic lateral Sclerosis Functional Rating ScaleRevised score,or progression rate.After adjusting for prognostic covariates,higher log creatine kinase values were correlated with higher overall survival in the amyotrophic lateral sclerosis patients.We also investigated the longitudinal changes in serum creatine kinase levels in 81 amyotrophic lateral sclerosis patients;serum creatine kinase levels were decreased at the second blood test,which was sampled at least 6 months after the first blood test.Together,our results suggest that serum creatine kinase levels can be used as an independent factor for predicting the prognosis of amyotrophic lateral sclerosis patients.This study received ethical approval from the Ethics Committee of West China Hospital,China(approval No.2015(236))on December 23,2015. 展开更多
关键词 amyotrophic lateral sclerosis BIOMARKER creatine kinase DIAGNOSIS epidemiological study prognosis SEROLOGY survival
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硼替佐米治疗新诊断多发性骨髓瘤期间心脏不良事件的影响因素及其对生存时间影响的真实世界研究 认领
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作者 申曼 黄仲夏 +4 位作者 李新 张佳佳 裴晓姣 潘振宇 陈文明 《中国全科医学》 CAS 北大核心 2021年第2期210-218,共9页
背景多发性骨髓瘤(MM)是一种易发生于老年群体的血液系统肿瘤,随着人口老龄化其发病率逐渐升高。随着硼替佐米等新型靶向药物的广泛应用,MM患者的中位生存期已延长至5~7年。多项个案报道硼替佐米用药期间的心脏不良事件(CAEs)病死率高,... 背景多发性骨髓瘤(MM)是一种易发生于老年群体的血液系统肿瘤,随着人口老龄化其发病率逐渐升高。随着硼替佐米等新型靶向药物的广泛应用,MM患者的中位生存期已延长至5~7年。多项个案报道硼替佐米用药期间的心脏不良事件(CAEs)病死率高,鲜见真实世界的影响因素分析。目的分析新诊断多发性骨髓瘤(NDMM)患者在应用硼替佐米期间出现CAEs的影响因素及其对生存时间的影响。方法选取2009年1月-2019年1月北京朝阳医院西院血液与肿瘤科收治的NDMM患者164例作为研究对象,以硼替佐米为基础的化疗方案作为一线诱导化疗方案,仅在接受硼替佐米的治疗过程中评估CAEs并分为CAEs组26例,对照组138例。CAEs组中分为急性CAEs亚组(第1疗程过程中出现的CAEs)与非急性CAEs亚组(第2疗程及之后出现的CAEs)。收集比较CAEs组和对照组的临床资料;记录CAEs组患者发生CAEs时硼替佐米的累积剂量以及发生CAEs时的临床表现;分析NDMM患者在应用硼替佐米期间出现CAEs的影响因素及CAEs对生存时间的影响。结果CAEs组年龄﹥65岁、吸烟、心脏病史、高血压史、高危细胞遗传学比例及血清肌酐(Scr)、乳酸脱氢酶(LDH)水平高于对照组,血红蛋白(HGB)水平低于对照组(P<0.05)。26例CAEs患者中急性CAEs 14例,非急性CAEs 12例。急性CAEs中位累积剂量为2.7 mg/m^2;非急性CAEs中位累积剂量为20.8 mg/m^2。急性CAEs患者均发生心力衰竭(100.0%),非急性CAEs患者中心力衰竭4例(33.3%),心房颤动4例(33.3%),静脉血栓栓塞2例(16.6%),急性冠脉综合征2例(16.6%)。呼吸困难与心悸为最常见的CAEs症状,其次为水肿和体质量增加。多因素Logistic回归分析结果显示,年龄≥66岁、吸烟、HGB<76 g/L、Scr≥176μmol/L、LDH≥173 U/L是应用硼替佐米治疗期间发生CAEs的危险因素(P<0.05)。CAEs组与对照组的中位总体生存时间(OS)分别为28、77个月,两组比较差异有统计� 展开更多
关键词 多发性骨髓瘤 诊断 硼替佐米 心脏不良事件 危险因素 生存
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暂存和运输方式对野生三疣梭子蟹暂养的影响 认领
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作者 韩胜明 任志明 +3 位作者 邱雪妮 杨华 母昌考 王春琳 《宁波大学学报:理工版》 CAS 2021年第1期8-14,共7页
三疣梭子蟹是我国重要的海产经济蟹类,野生梭子蟹的暂养是一种高效利用梭子蟹自然资源的经济手段.为探究适合野生三疣梭子蟹暂养的方法,研究了野生三疣梭子蟹捕捞后不绑螯堆积式暂存(M1)、绑螯单个体式暂存(M2)两种暂存方式以及橡皮筋... 三疣梭子蟹是我国重要的海产经济蟹类,野生梭子蟹的暂养是一种高效利用梭子蟹自然资源的经济手段.为探究适合野生三疣梭子蟹暂养的方法,研究了野生三疣梭子蟹捕捞后不绑螯堆积式暂存(M1)、绑螯单个体式暂存(M2)两种暂存方式以及橡皮筋绑螯堆叠盛放于塑料筐中运输(T1)、不绑螯单个盛放于单体盒中运输(T2)两种运输方式分别对其暂养存活的影响,并以超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)、丙二醛(MDA)、血糖、皮质醇、热休克蛋白(HSP70)几种生理指标了解其生理响应特征.结果显示:(1)不同暂存方式对野生三疣梭子蟹暂养的影响中,M2方式暂存的蟹暂养累积存活率为91.4%,显著高于M1(P<0.05),M1组蟹累积存活率为70.0%;根据对M1、M2组蟹血淋巴中几种生理指标的检测,引起两组蟹存活率差异的原因可能是M1暂存方式对蟹造成不可逆的损伤胁迫,抗氧化及应激能力显著降低,生理机能和免疫防御能力受损.(2)不同运输方式对野生三疣梭子蟹暂养的影响中,T2方式运输的蟹暂养累积存活率为41.5%,略高于T1(P>0.05),T1组蟹累积存活率为30.8%;根据对T1、T2组的蟹血淋巴中几种生理指标的检测,引起两组蟹存活率差异的原因可能是以T1方式运输的蟹受到挤压胁迫,抗氧化及应激能力略低于T2.综上分析,以绑螯单个体式的暂存方式和不绑螯单个盛放于单体盒中的运输方式获取的野生三疣梭子蟹更适合暂养. 展开更多
关键词 野生三疣梭子蟹 暂存方式 运输方式 暂养 存活
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文章速递根系分泌物对砷酸还原菌TS28活性及土壤中酶活性的影响 认领
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作者 郭平 徐富凯 +3 位作者 刘亦博 李美璇 封保根 陈薇薇 《吉林大学学报:理学版》 CAS CSCD 北大核心 2021年第1期183-189,共7页
以砷酸还原菌(Stenotrophomonas sp.TS28)以及油菜、小麦和小白菜的根系分泌物为实验对象,研究根系分泌物对砷(As)污染土壤中砷酸还原菌TS28存活、As还原能力的影响以及土壤中酶活性的变化规律.结果表明:土壤中的As(Ⅴ)抑制了TS28的活性... 以砷酸还原菌(Stenotrophomonas sp.TS28)以及油菜、小麦和小白菜的根系分泌物为实验对象,研究根系分泌物对砷(As)污染土壤中砷酸还原菌TS28存活、As还原能力的影响以及土壤中酶活性的变化规律.结果表明:土壤中的As(Ⅴ)抑制了TS28的活性,添加根系分泌物刺激了TS28的活性,增加了TS28的存活数量和存活时间;植物根系分泌物会影响TS28的As还原能力,影响程度与其来源有关,小麦的根系分泌物对TS28的As还原能力提升效果最好,10 d内将As(Ⅴ)的还原量提升了45.86%;TS28降低了As污染土壤中蔗糖酶和脱氢酶的活性,添加根系分泌物提高了含TS28的As污染土壤中脲酶、酸性磷酸酶、蔗糖酶和脱氢酶这4种土壤酶的活性,油菜根系分泌物的促进效果最好. 展开更多
关键词 根系分泌物 土壤 砷酸还原菌 存活 还原 酶活性
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COVID-19: A Physical Model 认领
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作者 Kai W. Wong Peter C. W. Fung Wan K. Chow 《生物物理学期刊(英文)》 2020年第2期88-95,共8页
The coronavirus structure is explained as a fractal representation of the Poincare sphere of proteins, dotted with t-spikes having the geometric realization of the SU(3) Lie group for the protein spike, and encompasse... The coronavirus structure is explained as a fractal representation of the Poincare sphere of proteins, dotted with t-spikes having the geometric realization of the SU(3) Lie group for the protein spike, and encompasses an RNA of SU(2) topologies representations, while within the core contains a virus DNA. Through this suggested model, the virus must possess a critical temperature Tc, induced by the EEM mechanism for the completion of the Poincare sphere surface. Thus above Tc it will disintegrate. We then discuss how the virus transmission progresses within the patient’s body, and explain a very fast recent detection method currently used consistent with this model, as well as a corresponding possible cure based on this same principle of the body’s immune system. Hopefully the model can be also used as a guide to finding possible medications, so far is lacking. 展开更多
关键词 COVID-19 Perelman MAPPINGS VIRUS SURVIVAL TEMPERATURE T VIRUS MULTIPLICATION MECHANISM
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Associations between Lesion Locations and Stroke Recurrence in Survivors of First-ever Ischemic Stroke:A Prospective Cohort Study 认领
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作者 Pe-jing YANI Li-sha HOU +8 位作者 Mi-er LI Zhen-xing LU Feng-yu ZHAN Meng-dong RAN Ji-je LI Lu ZHANG Rong YANG Mu-ke ZHOU Cai-rong ZHU 《当代医学科学(英文)》 SCIE CAS 2020年第4期708-718,共11页
Summary:Several studies have indicated that stroke survivors with multiple lesions or with larger lesion volumes have a higher risk of stroke recurrence.However,the relationship between lesion locations and stroke rec... Summary:Several studies have indicated that stroke survivors with multiple lesions or with larger lesion volumes have a higher risk of stroke recurrence.However,the relationship between lesion locations and stroke recurrence is unclear.We conducted a prospective cohort study of first-ever ischemic stroke survivors who were consecutively enrolled from January 2010 to December 2015.Stroke recurrence was assessed every 3 months after post-discharge via telephone interviews by trained interviewers.Lesion locations were obtained from hospital-based MRI or CT scans and classified using two classification systems that were based on cerebral hemisphere or vascular territory and brain anatomical structures.Flexible parametric survival models using the proportional hazards scale(PH model)were used to analyze the time-to-event data.Among 633 survivors,63.51%(n-402)had anterior circulation ischemia(ACI),and morc than half of all ACIs occurred in the subcortex.After a median follow-up of 2.5 years,117(18.48%)survivors developed a recurrent stroke.The results of the multivariate PH model showed that survivors with non-brain lesions were at higher risk of recurrence than those with right-side lesions(HR,2.79;95%CI,1.53,5.08;P-0.001).There was no increase in risk among survivors with left-side lesions(HR,0.97;95%CI,0.53,1.75;P=0.914)or both-side lesions(HR,1.24;95%CI,0.75,2.07;P-0.401)compared to those with right-side lesions.Additionally,there were no associations between stroke ecurrence and lesion locations that were classified based on vascular territory and brain anatomical structures.It was concluded that first-ever ischemic stroke survivors with non-brain lesion had higher recurrence risk than those with right-side lesion,although no significant associations were found when the lesion locations were classified by vascular territory and brain anatomical structures. 展开更多
关键词 ischemic stroke lesion location prevention RECURRENCE flexible parametric survival models survival analysis
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Significances of Peripheral Inflammatory Cells and Neutrophil/Platelet-Lymphocyte Ratio in Breast Cancer after Resection 认领
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作者 Pi-Fang Chen Chun-Chaing Lee +5 位作者 Ching-Kuen Pan Chen-Guo Ker Yu-Fu Chen Bo-Wei Wang Chin-Yi Chao Chia-Ling Lu 《生物科学与医学(英文)》 2020年第10期47-62,共16页
<strong>Introduction: </strong>Breast cancer had become top leading cause of death in Taiwan and endangered women’s health worldwide. Therefore, we try to invest the peripheral inflammatory cell counts an... <strong>Introduction: </strong>Breast cancer had become top leading cause of death in Taiwan and endangered women’s health worldwide. Therefore, we try to invest the peripheral inflammatory cell counts and neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) from our routine practice for the predictor of prognosis of breast cancer after resection. <strong>Patients and</strong> <strong>Methods: </strong>There were 574 breast cancer patients accepted surgical resection and registered in Cancer Registry Center of our hospital. Patient’s basic profiles, peripheral neutophil, lymphocyte and platelet count were measured for study. The scales of NLR and PLR were derived from the lower and higher normal range in cell count from neutrophil, lymphocyte and platelet respectively. Therefore, the scales for NLR and PLR were ≤1.62, 1.63 - 2.57, ≥2.58 and ≤224, 225 - 253, ≥254 respectively for analysis. <strong>Results: </strong>Poor 5-yr survival rate was found if higher cell counts of neutrophil and platelet (p ≤ 0.05). Three scales of NLR were ≤1.62, 1.63 - 2.57, ≥2.58, and their 5-year survival rates were 94%, 91% and 84% respectively (p = 0.019). In the subgroup of HER-2 (negative), and 3-Negative breast patients had a higher NLR of poor prognosis. But higher PLR was found less in 3-Negative and non in 3-Positive patients (p = 0.039). The PLR was ≤224, 225 - 253, ≥254 and their 5-year survival rates were 92%, 87%, and 64% respectively (p = 0.001);Multivariate Cox regression model for predictor of breast cancer patients who have 3.39 (PLR ≥ 254) and 2.45 (NLR ≥ 2.58 ) times risk (p = 0.02 and p = 0.002) of poor prognosis respectively. <strong>Conclusion: </strong>Peripheral inflammatory cell counts are easily to take in our clinical practice and have a potential role as predictors of prognosis. We have to pay attention to the trends of peripheral inflammatory cell count and their ratio in our clinical practice where possible. 展开更多
关键词 Inflammatory Cell Neutrophil-Lymphocyte Ratio Platelet-Lymphocyte Ratio Cancer Prognosis Survival Rate
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Analysis of the Effects of Botulinum Toxin Type A to Promote the Survival of Transverse Rectus Abdominis Myocutaneous Flaps in an Animal Model 认领
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作者 Erika Otilia Haro García Edna M. Aizpuru +3 位作者 Jorge Eduardo Gutierrez Salgado Maria Irene Rivera Salgado Jose Telich Vidal Olin Carrasco Ortiz 《生物科学与医学(英文)》 2020年第10期63-73,共11页
The transverse rectus abdominis myocutaneous (TRAM) flap is one of the techniques for breast reconstruction surgery and other defects. Assuring the vascular input is the main factor that it should be ensured for the s... The transverse rectus abdominis myocutaneous (TRAM) flap is one of the techniques for breast reconstruction surgery and other defects. Assuring the vascular input is the main factor that it should be ensured for the survival of the fap. <strong>Objective:</strong> The article presented is an experimental study, with the objective of evaluating the effect of the vasculature on the myocutaneous flaps of the abdominal rectum with botulinum toxin type A (TBoA) thay may improve the survival of the tissue by promoting the blood perfusion in distal parts of the flap and diminish the risk of necrosis. <strong>Material and methods:</strong> A total of 30 Wistar male rats, dissect pedicled right TRAM flap in all rats, divided into three groups: Group 1 was applied in saline solution 0.9%;Group 2 was applied in pre surgically TBoA (1 week before lifting the flap);Group 3, will apply TBOA Trans surgical. <strong>Results:</strong> Histological analysis showed: increased vascularity in group 2 TBoA compared with the saline solution with P < 0.05 statistically significant. In terms of fibrosis, inflammation and granulation tissue, there was no statistically significant difference at p = 0.6. Muscle atrophy was higher in the group of TBoA in the saline group p < 0.05. It was concluded that botulinum toxin type A prevents vasoconstriction of the vessel and promotes vasodilation subsequently lifting the muscle flap, no complications were observed in the groups with TBoA so it can be considered a safe substace and can be used for further studies. 展开更多
关键词 Botulinum Toxin Tranverse Rectus Abdominis Myocutaneos Flap VASODILATATION SURVIVAL
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The Prognostic and Curative Benefits of Primary Tumor Resection versus No Resection in Stage IV Colorectal Cancer: A Comparative Study 认领
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作者 Ibtsam Shehta Harera Taha A. Baiomy +5 位作者 Ahmed A. Obaya Shady E. Shaker Amr Samir Ahmed M. Elsayed Enas Mahmoud Hamed Loay M. Gertallah 《外科学(英文)》 2020年第3期39-49,共11页
Background: Colorectal cancer (CRC) who is initially diagnosed with single or multiple synchronous distant metastases has an incidence of about 20% of all CRC patients. There is a controversy regarding the role of res... Background: Colorectal cancer (CRC) who is initially diagnosed with single or multiple synchronous distant metastases has an incidence of about 20% of all CRC patients. There is a controversy regarding the role of resection of the primary tumors in those patients. The aim of this study was to explore the prognostic roles and survival advantages of surgical excision of the primary colonic tumor in patients with CRC who are primarily diagnosed with distant metastases. Patients and Methods: We included forty patients who were diagnosed initially with stage IV CRC. We have divided the included patients into two categories the first one included 20 patients that underwent surgical excision of the primary cancer followed by administration of chemotherapy and the remaining 20 patients were initially given chemotherapy without excision of the cancer. We followed patients for 24 months to detect progression, response to chemotherapy, recurrence free survival and overall survival rates. Results: There is statistically significant difference between patients underwent different initial management techniques regarding N stage of the tumor (p = 0.039), response to chemotherapy (p = 0.048), occurrence of relapse (p = 0.022), disease free survival (DFS) (p = 0.027) or overall survival (OS) rates (p = 0.001) (DFS and OS were significantly higher among patients who received initial surgical management. Primary surgical removal of the tumor improved OS rate by 8 months (p = 0.001). Conclusion: Surgical removal of the primary malignancy in mCRC patients before chemotherapy administration improves patients’ survival rates and response to chemotherapy that lead to a better prognosis. 展开更多
关键词 METASTATIC CRC (mCRC) Surgical RESECTION Chemotherapy Survival
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Mutation Analysis of EGFR Gene in Patients with Non-Small Cell Lung Cancer in Xinjiang 认领
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作者 Yi Shi Xuelian Pang +3 位作者 Zhiping Ma Wenli Cui Yuqing Ma Wei Zhang 《临床医学国际期刊(英文)》 2020年第4期144-153,共10页
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links extracellular signals to the control of cell survival, growth, proliferation and differentiation. EGFR has been a therapeutic ... The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links extracellular signals to the control of cell survival, growth, proliferation and differentiation. EGFR has been a therapeutic target for human malignancies, due to its frequent hyperactivation, therefore, it is necessary to investigate the characteristics of EGFR mutation, and identify patients who are likely to benefit from EGFR mutation. In this study, we examined 766 non-small cell lung cancer (NSCLC) patients (675 tissue, 83 thoracic water precipitation and 8 plasma samples) tested in pathology department of First Affiliated Hospital of Xinjiang Medical University from 2013 to 2017 by using ARMS-PCR method. The correlation between EGFR mutations and clinical pathological features was further explored. Subgroup analyses according to ethnicity, histological type, sample type, and tumour grade were done. Subgroup analyses showed the mutation rate of tumor tissue, thoracic water precipitation and plasm was 30.5%, 37.3%, 50.0% respectively. We found female (p < 0.0001), no smoking (p < 0.001), adenocarcinoma (p < 0.0001), and tissue specimens (Tobacco use) were associated with higher EGFR mutation rate. The most common mutations were exon 19 deletions (47.30%) and L858R point (42.32%) mutation. We have not found any differences between EGFR mutations and ethnic groups especially. In addition, we did not find differences in common mutations and rare sensitive mutations in the survival of targeted therapies. 展开更多
关键词 NON-SMALL Cell LUNG Cancer EGFR MUTATIONS SURVIVAL
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Construction of <i>k</i>-Variate Survival Functions with Emphasis on the Case <i>k</i>= 3 认领
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作者 Jerzy K. Filus Lidia Z. Filus 《应用数学(英文)》 2020年第7期678-697,共20页
The purpose of this paper is to present a general universal formula for <span style="font-family:Verdana;"><i></i></span><i><span><span><i><span style="... The purpose of this paper is to present a general universal formula for <span style="font-family:Verdana;"><i></i></span><i><span><span><i><span style="font-family:Verdana;">k</span></i><span style="font-family:Verdana;"></span></span></span></i><span><span><span style="font-family:Verdana;">-variate survival functions for arbitrary </span><span style="font-family:Verdana;"><i></i></span></span></span><i><span><span><i><span style="font-family:Verdana;">k</span></i><span style="font-family:Verdana;"></span></span></span></i><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2, 3, </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">...</span><span style="font-family:Verdana;">, given all the univariate marginal survival functions. This universal form of </span></span><span style="font-family:Verdana;"><i></i></span></span></span><i><span><span><i><span style="font-family:Verdana;">k</span></i><span style="font-family:Verdana;"></span></span></span></i><span><span><span style="font-family:Verdana;">-variate probability distributions was obtained by means of “dependence functions” named “joiners” in the text. These joiners determine all the involved stochastic dependencies between the underlying random variables. However, in order that the presented formula (the form) represents a legitimate survival function, some necessary and sufficient conditions for the joiners had to be found. Basically, finding those conditions is the main task of this paper. This task was successfully performed for the case </span><span style="font-family:Verdana;"><i></i></span></span></span><i><span><span><i><span style="font-family:Verdana;">k</span></i><span style="font-family:Verdana;"></span></span></span></i><span><span><span style="font-family:Verdana;"> = 2 and the main results for the case </span><span style="font-family:Verdana;"><i></i></span></span></span><i><span><span><i><span style="font-family:Verdana;">k</span>< 展开更多
关键词 Construction of Multivariate Probability Distributions via Joiners Joiner versus Copula Methodology A Possible Fusion of the Two Construction Methods k -Variate Survival Function Scheme k = 3 Case
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2003—2013年广东省中山市主要癌症净生存率分析 认领 被引量:1
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作者 魏矿荣 梁智恒 李柱明 《中国肿瘤》 CAS CSCD 北大核心 2020年第2期103-107,共5页
[目的]评价中山市癌症防治效果。[方法]收集整理2003—20013年诊断、户籍为广东省中山市的主要癌症的生存资料,统计分析其净生存率。[结果]2003—2013年期间,中山市共有符合研究条件的18种主要癌症患者26046例,不同癌症5年标化净生存率... [目的]评价中山市癌症防治效果。[方法]收集整理2003—20013年诊断、户籍为广东省中山市的主要癌症的生存资料,统计分析其净生存率。[结果]2003—2013年期间,中山市共有符合研究条件的18种主要癌症患者26046例,不同癌症5年标化净生存率明显不同。2010—2013年主要癌症5年标化净生存率位于11.7%~74.5%,女性乳腺癌最高,食管癌最低,女性乳腺癌、宫颈癌、结肠癌、儿童急性淋巴母细胞性白血病、直肠癌和前列腺癌的5年标化净生存率>50%,成人淋巴性恶性肿瘤和脑肿瘤,卵巢癌和儿童脑肿瘤的5年标化净生存率位于30%~50%之间,食管、胰腺、肝、肺和胃癌与成人髓样恶性肿瘤的5年标化净生存率<30%。多数癌症的5年标化净生存率比1995—1999年明显上升。[结论]2010—2013年中山市多数主要癌症生存率位于全球CONCORD-3参与地区的中低或较低水平,提示中山市应采取措施以提高其人群癌症生存率。 展开更多
关键词 癌症 生存 5年标化净生存率 广东
On the Application of Nadarajah Haghighi Gompertz Distribution as a Life Time Distribution 认领
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作者 Adebisi Ade Ogunde Isaac Oluwaseyi Ajao Gbenga Adelekan Olalude 《统计学期刊(英文)》 2020年第5期850-862,共13页
The convolution of Nadarajah-Haghighi-G family of distributions will result <span style="font-family:Verdana;">into a more flexible distribution (Nadarajah-Haghighi Gompertz distribution) </span>... The convolution of Nadarajah-Haghighi-G family of distributions will result <span style="font-family:Verdana;">into a more flexible distribution (Nadarajah-Haghighi Gompertz distribution) </span><span style="font-family:Verdana;">than each of them individually in terms of the estimate of the characteristics in there parameters. The combination was done using Nadarajah-Haghighi </span><span style="font-family:Verdana;">(NH) generator. We investigated in the newly developed distribution some basic </span><span style="font-family:Verdana;">properties including moment, moment generating function, survival rate function, hazard rate function asymptotic behaviour and estimation of parameters. The proposed model is much more flexible and has a better representation of data than Gompertz distribution and some other model considered. A real data set was used to illustrate the applicability of the new model.</span> 展开更多
关键词 Moment Generating Function Nadarajah-Haghighi Generator Gompertz Distribution Survival Rate Function MOMENT
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Self-Sustained Boundedness of Logical and Quantal Error at Semantic Intelligence 认领
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作者 Maria K. Koleva 《现代物理(英文)》 2020年第2期157-167,共11页
It is demonstrated that the recently introduced semantic intelligence spontaneously maintains bounded logical and quantal error on each and every semantic trajectory, unlike its algorithmic counterpart which is not ab... It is demonstrated that the recently introduced semantic intelligence spontaneously maintains bounded logical and quantal error on each and every semantic trajectory, unlike its algorithmic counterpart which is not able to. This result verifies the conclusion about the assignment of equal evolutionary value to the motion on the set of all the semantic trajectories sharing the same homeostatic pattern. The evolutionary value of permanent and spontaneous maintenance of boundedness of logical and quantal error on each and every semantic trajectory is to make available spontaneous maintenance of the notion of a kind intact in the long run. 展开更多
关键词 SEMANTIC INTELLIGENCE Algorithmic INTELLIGENCE BOUNDEDNESS Logical ERROR Quantal ERROR Optimization Survival of the Fittest Notion of a KIND
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Prognostic factors for pN2 non-small cell lung cancer:a comprehensive evidence from 73 studies involving 23,772 patients 认领
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作者 Shuo Li Yanlin Feng +1 位作者 Chunzi Liang Jiancheng Tu 《肿瘤学与转化医学:英文版》 2020年第2期57-63,共7页
Obojective Non-small-cell lung cancer(NSCLC)is a common malignancy.pN2 NSCLC,with pathologically confirmed ipsilateral mediastinal/subcarinal nodes metastasis,has been known as a very heterogeneous subgroup in terms o... Obojective Non-small-cell lung cancer(NSCLC)is a common malignancy.pN2 NSCLC,with pathologically confirmed ipsilateral mediastinal/subcarinal nodes metastasis,has been known as a very heterogeneous subgroup in terms of its anatomical,biological and patient characteristics.Prognostic factors based on patient characteristics were not well determined yet in this subgroup,and there is currently no standard treatment recommendation for these heterogeneous pN2 subjects.Apparent disagreements and inconsistency exist in study reports concerning the prognostic significance of certain factors in pN2 NSCLC,especially regarding to the issue about whether skip N2 metastasis benefit from surgery.Methods We therefore performed this comprehensive summary of the published literatures to draw a more precise and less uncertain conclusion.After a comprehensive literature search,a total of 73 studies involving 23,773 subjects were included according to eligibility criteria.Results As expected,most of the investigated factors,such as old age,male,advanced pathological T stage,advanced clinical N stage,multiple N2 stations,extended surgical resection(pneumonectomy),and incomplete resection,but not post-operation treatment(eg.chemotherapy and radiotherapy)were significantly associated with poor survival.However,skip N2 metastasis was favourable prognostic factors in operable pN2 NSCLC subjects.Other factors(histological type and primary tumour side)were neutral in terms of association with overall survival.We highlighted a number of important prognostic factors for pN2 NSCLC patients.Particularly,patients with skip N2 disease benefit from surgery.Conclusion Our findings could be used as reference information for decision-making in clinical practice and future study design. 展开更多
关键词 non-small cell lung cancer META-ANALYSIS prognostic factors overall survival
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The Prediction Value of the Infection Probability Score (IPS) Combined with Serum Cholinesterase and D-Dimer Detection for Infection and Survival in Critically Ill Patients 认领
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作者 Qian Zhao Huijun Qi +2 位作者 Hui Guo Zhangshun Shen Jianguo Li 《临床医学病理报告(英文)》 2020年第8期228-235,共8页
<strong>Objective:</strong> To evaluate early prediction value of IPS<span> </span><span><span style="font-family:Verdana;">combined with SchE and D-dimer detection for in... <strong>Objective:</strong> To evaluate early prediction value of IPS<span> </span><span><span style="font-family:Verdana;">combined with SchE and D-dimer detection for infection and survival in critically ill patients. </span><b><span style="font-family:Verdana;">Methods:</span></b></span><b><span> </span></b><span style="font-family:Verdana;">199 critically ill patients admitted to the emergency intensive care unit (EICU) of our hospital from December 2018 to December 2019 were retrospectively analyzed, including 110 infection patients (infection group) and 89 non-infection</span><span> </span><span style="font-family:Verdana;">patients (non-infection group).</span><span> </span><span><span style="font-family:Verdana;">According to the survival, the infection group was divided into death group (68 cases) and survival group (42 cases). The IPS, APACHE II, SOFA and SchE, D-dimer expression levels were detected and compared;Univariate and logistic regression analysis were used to evaluate the independent prognostic factors. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The IPS and APACHE II of patients in the infected group were higher than those in the non-infected group, the level of SchE was lower than that in the non-infected group, and the level of D-dimer was higher than that in the non-infected group (</span><i><span style="font-family:Verdana;">P</span></i></span><i><span> </span></i><span style="font-family:Verdana;"><</span><span> </span><span style="font-family:Verdana;">0.001). IPS, SOFA, APACHE</span><span style="font-family:Verdana;"> II</span><span style="font-family:Verdana;">, SchE, D-dimer, invasive mechanical ventilation, septic shock, and ICU length</span><span style="font-family:Verdana;"> of stay had significant influence on the prognosis of critically ill patients</span><span> </span><span><span style="font-family:Verdana;">(</span><i><span style="font-family:Verdana;">P</span></i></span><i><span> </span></i><span style="font-family:Verda 展开更多
关键词 Critical Illness INFECTION Infection Probability Score (IPS) CHOLINESTERASE D-DIMER Survival Prognosis
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Field Durability of <i>Yorkool<sup>®</sup>LN</i>Nets in the Benin Republic 认领
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作者 I. B. Ahogni R. Y. Aï +14 位作者 kpon R. A. Ossè J. F. Dagnon R. Govoetchan R. H. Attolou A. Agbevo R. Azondekon C. Z. Koukpo V. Gnanguenon H. Sagbohan C. Kpanou F. Tokponon B. Akinro G. G. Padonou M. C. Akogbeto 《昆虫学(英文)》 2020年第1期72-92,共21页
Context: Recent publications on WHO recommended methods for estimating the survival of LLINs are good guidelines for assessing the performance of long-lasting insecticidal nets (LLINs). Thus, this field trial study wa... Context: Recent publications on WHO recommended methods for estimating the survival of LLINs are good guidelines for assessing the performance of long-lasting insecticidal nets (LLINs). Thus, this field trial study was undertaken to evaluate the durability of the Yorkool? LN mosquito net distributed during the 2017 campaign in Benin. Methods: The monitoring of Yorkool? LN nets was carried out in two districts (Djougou III and Barienou) in Djougou, department of Donga, northern Benin from October 2017 to March 2019. A representative sample of 250 households that had received the Yorkool? LN polyester LLINs during the 2017 campaign was selected in the rural and urban areas of each district and monitored for 6, 12 and 18 months. An evaluation of the survival of Yorkool? LN nets was conducted based on the rate of loss and physical condition of the surviving nets as measured by the proportional hole index (pHI). Finally, the chemical efficacy of these LLINs during each period was determined using the WHO cone tests. Results: Survival of Yorkool? LN nets was similar in both rural and urban areas, although there was a difference in survival between the 6-month (95.3%), 12-month (89.7%), and 18-month follow-up periods (74.4%). A difference in survival was also observed between the NetCalc model (84%) compared to the Yorkool? LN nets of this study (74.4%). The attrition rate was 29.6% for LLINs at 18 months. Surprisingly, the physical integrity of the LLINs was minimally affected in the municipality. Indeed, the proportion of mosquito nets in good condition without a hole was 51.8% compared to 56.8% with a hole after 18 months. Only 7.8% of the LLINs in the two districts were damaged compared to 2.6% which needed to be replaced. The washing frequency, location of the LLINs and the frequency of use are some factors contributing to the appearance of the holes in LLINs. The bio-efficacy results of LLINs based on the cone test were good with mortality rates of 74%, 66%, 72% and 58% respectively after baseline, 6, 12 and 18 mo 展开更多
关键词 DURABILITY Yorkool? LN LLINs Survival Physical INTEGRITY Bio-Efficacy
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Survival Analysis of Lung Cancer Patients from TCGA Cohort 认领
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作者 Ruibin Lyu 《肺癌(英文)》 2020年第1期1-15,共15页
Lung cancer is one of the leading causes of death worldwide, accounting for an estimated 2.1 million cases in 2018. To analyze the risk factors behind the lung cancer survival, this paper employs two main models: Kapl... Lung cancer is one of the leading causes of death worldwide, accounting for an estimated 2.1 million cases in 2018. To analyze the risk factors behind the lung cancer survival, this paper employs two main models: Kaplan-Meier estimator and Cox proportional hazard model [1]. Also, log-rank test and wald test are utilized to test whether a correlation exists or not, which is discussed in detail in later parts of the paper. The aim is to find out the most influential factors for the survival probability of lung cancer patients. To summarize the results, stage of cancer is always a significant factor for lung cancer survival, and time has to be taken into account when analyzing the survival rate of patients in our data sample, which is from TCGA. Future study on lung cancer is also required to make improvement for the treatment of lung cancer, as our data sample might not represent the overall condition of patients diagnosed with lung cancer;also, more appropriate and advanced models should be employed in order to reflect factors that can affect survival rate of patients with lung cancer in detail. 展开更多
关键词 LUNG Cancer SURVIVAL Analysis Kaplan-Meier ESTIMATOR COX Proportional HAZARD Model
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Study of Factors Associated with the Age of Natural Menopause in Menopausal Women Aged 30 to 80 Years from the Keur Massar Health District in 2015 (Senegal) 认领
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作者 Fatoumata Binetou Diongue Adama Faye +4 位作者 Khadim Niang Jean Augustin Diégane Tine Amadou Ibra Diallo Rodrigue Magloire Eyema Anta Tal-Dia 《健康(英文)》 2020年第10期1333-1344,共12页
<strong>Introduction: </strong>Menopause is a biological phenomenon that occurs at a more or less early or late age in the life of every woman. The general objective is to study the factors associated with... <strong>Introduction: </strong>Menopause is a biological phenomenon that occurs at a more or less early or late age in the life of every woman. The general objective is to study the factors associated with the age of natural menopause in menopausal women aged between 30 and 80 years who have gone through down Keur Massar health district in 2015. <strong>Methodology:</strong> This was an observational, cross-sectional, descriptive and analytical study conducted in Keur Massar health district from December 1<sup>st</sup> to 10<sup>th</sup>, 2015. Two-stage cluster sampling was conducted. Data were collected during an individual interview at home after consent. They covered socio-economic conditions, health and nutrition status, gynecological-obstetrical history, and lifestyle. A multivariate analysis was performed using the Cox model with a 5% risk of alpha error. <strong>Results: </strong>A total of 627 postmenopausal women were surveyed. Mean age of these women was 54.5 years (±8.6 years). A proportion of 72.1% of the women was married and 46.7% was in school. Mean age of natural menopause was 47.1 years (±5.03 years). The median age of natural menopause was 47 years. Factors associated with the age of natural menopause were high parity of more than 4 children (Hra = 0.35 [0.13 - 0.92]), the existence of frequent childhood illnesses (Hra = 1.72 [1.13 - 2.64]), use of the intra-uterine device—IUD—as a modern contraceptive method (HRa = 0.39 [0.24 - 0.63]), sibling size (HRa = 0.85 [0.78 - 0.93]), family size (HRa = 1.03 [1.01 - 1.06]), and polygamy regime (HRa = 0.56 [0.37 - 0.85]). <strong>Conclusion: </strong>Many factors in childhood as well as during the period of female genital activity can impact the age of natural menopause. It is then important to improve the health status of women, children and the standard of living of the population. 展开更多
关键词 Age Menopause Associated Factors SURVIVAL Senegal
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