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Human umbilical cord mesenchymal stem cells to treat spinal cord injury in the early chronic phase: study protocol for a prospective, multicenter, randomized, placebo-controlled, single-blinded clinical trial 预览
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作者 Yang Yang Mao Pang +5 位作者 Yu-Yong Chen Liang-Ming Zhang Hao Liu Jun Tan Bin Liu Li-Min Rong 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第8期1532-1538,共7页
Human umbilical cord mesenchymal stem cells(hUC-MSCs)support revascularization,inhibition of inflammation,regulation of apoptosis,and promotion of the release of beneficial factors.Thus,they are regarded as a promisin... Human umbilical cord mesenchymal stem cells(hUC-MSCs)support revascularization,inhibition of inflammation,regulation of apoptosis,and promotion of the release of beneficial factors.Thus,they are regarded as a promising candidate for the treatment of intractable spinal cord injury(SCI).Clinical studies on patients with early chronic SCI(from 2 months to 1 year post-injury),which is clinically common,are rare;therefore,we will conduct a prospective,multicenter,randomized,placebo-controlled,single-blinded clinical trial at the Third Affiliated Hospital of Sun Yat-sen University,West China Hospital of Sichuan University,and Shanghai East Hospital,Tongji University School of Medicine,China.The trial plans to recruit 66 early chronic SCI patients.Eligible patients will undergo randomization at a 2:1 ratio to two arms:the observation group and the control group.Subjects in the observation group will receive four intrathecal transplantations of stem cells,with a dosage of 1×106/kg,at one calendar month intervals.Subjects in the control group will receive intrathecal administrations of 10 mL sterile normal saline in place of the stem cell transplantations.Clinical safety will be assessed by the analysis of adverse events and laboratory tests.The American Spinal Injury Association(ASIA)total score will be the primary efficacy endpoint,and the secondary efficacy outcomes will be the following:ASIA impairment scale,International Association of Neural Restoration-Spinal Cord Injury Functional Rating Scale,muscle tension,electromyogram,cortical motor and cortical sensory evoked potentials,residual urine volume,magnetic resonance imaging–diffusion tensor imaging,T cell subtypes in serum,neurotrophic factors and inflammatory factors in both serum and cerebrospinal fluid.All evaluations will be performed at 1,3,6,and 12 months following the final intrathecal administration.During the entire study procedure,all adverse events will be reported as soon as they are noted.This trial is designed to evaluate the clinical safety and e 展开更多
关键词 clinical study early chronic phase efficacy human umbilical cord mesenchymal stem cell multicenter trial prospective study randomized controlled trial safety spinal cord injury study protocol
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三峡库区山区农业生态系统转型
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作者 梁鑫源 李阳兵 +1 位作者 邵景安 冉彩虹 《地理学报:英文版》 SCIE CSCD 2020年第2期281-296,共16页
The Three Gorges Reservoir Area(TGRA)is typical of an ecologically vulnerable area,comprised of rural and mountainous areas,and with high immigration.Because of its economic and ecologic importance,studying the tradit... The Three Gorges Reservoir Area(TGRA)is typical of an ecologically vulnerable area,comprised of rural and mountainous areas,and with high immigration.Because of its economic and ecologic importance,studying the traditional agroecosystem changes in the TGRA is key to rural development and revitalization.In this study,we apply a framework of theoretical analysis,empirical study,and trend prediction to the Caotangxi River watershed within the TGRA.Using QuickBird high-resolution remote sensing images from 2012 to 2017 to evaluate natural resources and farmers’behavior,we analyze the transition and trends in the traditional agroecosystem in mountainous areas of the TGRA at spatial scale of the man-land relationship.We find that the agroecosystem in the TGRA can be divided into four modes using 100 m interval buffer rings:high-low-low,high-low-high,low-high-low and low-low-high mode where the different modes represent the agricultural development stages in the TGRA.Furthermore,the traditional agroecosystem in TGRA,represented by system elements such as farmers and sloping farmland,is transforming to accommodate the diversification of farmer livelihoods.For example,sloping farmland,which was dominated by a production function,now has equal emphasis on ecological and economic functions.Spatially,the range of the agroecosystem transition has migrated beyond high mountain areas to flat valley areas.Generally,this study provides an overview of land use in rural areas,controls on soil and water loss in mountainous areas,and better rural living environments in the TGRA. 展开更多
关键词 Three Gorges Reservoir Area ecologically fragile area mountainous area traditional agroecosystem transition empirical study spatial scale
辽西地区新石器时代晚期前段聚落研究 预览
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作者 熊增珑 《吉林师范大学学报:人文社会科学版》 2020年第1期60-64,共5页
新石器时代晚期是中国史前时期社会大变革的时期,在聚落形态上自然有所反应。这一阶段的考古学文化包括赵宝沟文化、富河文化、红山文化早中期。目前发掘了数十处遗址,为聚落研究奠定了基础。通过对这一时期的聚落特征进行总结,在此基... 新石器时代晚期是中国史前时期社会大变革的时期,在聚落形态上自然有所反应。这一阶段的考古学文化包括赵宝沟文化、富河文化、红山文化早中期。目前发掘了数十处遗址,为聚落研究奠定了基础。通过对这一时期的聚落特征进行总结,在此基础上对当时社会组织、生业系统、手工业和贸易情况进行初步探讨。 展开更多
关键词 辽西地区 新石器时代 聚落 研究
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Double-row repair of rotator cuff tears: Comparing tendon contact area between techniques 预览
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作者 Shao Hui Allan Ng Chung Hui James Tan 《世界骨科杂志(英文版)》 2020年第1期10-17,共8页
BACKGROUND In rotator cuff repair surgery,the double-row technique is widely performed.Studies have shown that with increased contact area and pressure between tendon and bone interface,better healing is promoted.AIM ... BACKGROUND In rotator cuff repair surgery,the double-row technique is widely performed.Studies have shown that with increased contact area and pressure between tendon and bone interface,better healing is promoted.AIM To assess the different suture configurations with the double-row technique and how this influences the contact area of the rotator cuff tendon to bone.METHODS This was a controlled laboratory study where identical tears were created in 24 fresh porcine shoulders over a 1.5 cm×2.5 cm infraspinatus insertion footprint.Double-row repair techniques,with 3 to 4-suture anchors in different configurations(2 medial,2 lateral vs 2 medial,1 lateral vs 1 medial,2 lateral),were employed for three control groups.Each group consisted of eight shoulders with identical repair configurations.Footprint contact areas of the repaired tendon against the tuberosity were determined using pressure sensitive Fujifilm placed between the tendon and tuberosity.RESULTS The mean contact area between tendon and insertion footprint from the imprinted Fujifilm was obtained using computer software.The contact area measured from a standard 4-suture anchor double row repair was 75.1±9.3 mm2,whereas areas obtained for the 2 lateral-1 medial and 2 medial-1 lateral anchor configurations were 72.9±5.2 mm2 and 75.0±4.9 mm2 respectively.No statistical significance was noted between the three groups.CONCLUSION In the technique of double-row repair,using a 3-suture anchor configuration may offer a non-inferior alternative to the standard 4-anchor construct in terms of efficacy.This may also result in overall cost reduction and shorter surgical time. 展开更多
关键词 Basic science study Double-row Different suture anchor configurations Footprint contact area Porcine model Pressure sensitive film Tendon healing
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农村饮用水水源地硝酸盐污染特性研究 预览
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作者 安宝明 徐从海 黄永军 《水资源开发与管理》 2020年第2期52-55,共4页
农业面源污染是农村饮用水水源地的主要污染因素,其中以硝酸盐污染问题最为突出。根据山东省沂水县域内279处地下水型农村饮用水水源地水质检测结果,本文从取水深度、海拔高程、地形坡度等3个方面对农村饮用水水源地的硝酸盐污染特性进... 农业面源污染是农村饮用水水源地的主要污染因素,其中以硝酸盐污染问题最为突出。根据山东省沂水县域内279处地下水型农村饮用水水源地水质检测结果,本文从取水深度、海拔高程、地形坡度等3个方面对农村饮用水水源地的硝酸盐污染特性进行了系统研究。结果表明,水源地硝酸盐超标率和超标程度均会随着水源地取水深度、海拔高程以及地形坡度的升高而降低。研究结论可为主管部门采取有效的预防和治理措施提供借鉴,并可指导新建水源地的选址。 展开更多
关键词 农村饮用水源地 硝酸盐 面源污染 研究
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基于AMESim的柱塞泵EP2D控制特性研究 预览
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作者 张兴越 刘雨 杨光华 《液压气动与密封》 2020年第2期38-41,共4页
该文简述了A11V变量泵带压力切断的电子控制(EP2D)的工作原理,通过对EP2D变量机构进行分析,建立了柱塞泵EP2D控制的数学模型,得出了调压弹簧刚度、大变量缸截面积、反馈弹簧刚度和流量系数是影响控制稳定性的主要因素,并通过AMESim软件... 该文简述了A11V变量泵带压力切断的电子控制(EP2D)的工作原理,通过对EP2D变量机构进行分析,建立了柱塞泵EP2D控制的数学模型,得出了调压弹簧刚度、大变量缸截面积、反馈弹簧刚度和流量系数是影响控制稳定性的主要因素,并通过AMESim软件建立了相应的仿真模型进行论证;最后,通过试验论证相关设计参数的正确性。 展开更多
关键词 EP2D 控制特性 AMESIM 研究
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Software Vulnerabilities Overview:A Descriptive Study
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作者 Mario Calm Sanchez Juan Manuel Carrillo de Gea +2 位作者 Jose Luis Fernandez-Aleman Jesus Garceran Ambrosio Toval 《清华大学学报自然科学版(英文版)》 EI CAS CSCD 2020年第2期270-280,共11页
Computer security is a matter of great interest.In the last decade there have been numerous cases of cybercrime based on the exploitation of software vulnerabilities.This fact has generated a great social concern and ... Computer security is a matter of great interest.In the last decade there have been numerous cases of cybercrime based on the exploitation of software vulnerabilities.This fact has generated a great social concern and a greater importance of computer security as a discipline.In this work,the most important vulnerabilities of recent years are identified,classified,and categorized individually.A measure of the impact of each vulnerability is used to carry out this classification,considering the number of products affected by each vulnerability,as well as its severity.In addition,the categories of vulnerabilities that have the greatest presence are identified.Based on the results obtained in this study,we can understand the consequences of the most common vulnerabilities,which software products are affected,how to counteract these vulnerabilities,and what their current trend is. 展开更多
关键词 descriptive study software security software vulnerabilities vulnerability databases
意象图式视阈下介词的习得研究——以英语介词over为例 预览
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作者 周紫荆 《黑龙江生态工程职业学院学报》 2020年第1期154-157,共4页
在意象图式视阈下对介词的习得进行研究。根据Lakoff的意象图式理论,对介词over的多义现象进行具象化的分析,并拓展出介词over在不同认知域下的不同词义,表明英语介词可以通过意象图式法进行有效的学习,并能帮助学生在理解原型意义的基... 在意象图式视阈下对介词的习得进行研究。根据Lakoff的意象图式理论,对介词over的多义现象进行具象化的分析,并拓展出介词over在不同认知域下的不同词义,表明英语介词可以通过意象图式法进行有效的学习,并能帮助学生在理解原型意义的基础上,通过联想进行词汇认知域的拓展,有助于学习者对介词的理解和掌握。研究发现,意象图式法能够将抽象的介词具体化,有效解决学生对英语介词词义理解不到位及词义记忆不完整等问题,提升学习者的学习效率。 展开更多
关键词 意象图式 英语介词over 习得
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运载火箭电液伺服系统多余物识别与防控措施研究 预览
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作者 叶朋 郑波 +3 位作者 赵春 王剑 刘新 芦星竹 《液压气动与密封》 2020年第2期78-83,共6页
针对运载火箭配套电液伺服系统产品结构复杂、生产工序繁琐、易生多余物、且其性能受多余物影响大的特点,现以提产品可靠性为目的,基于液压回路和电气回路的工作特点,分析多余物来源和典型故障模式,结合近年来质量问题数据统计,采用故... 针对运载火箭配套电液伺服系统产品结构复杂、生产工序繁琐、易生多余物、且其性能受多余物影响大的特点,现以提产品可靠性为目的,基于液压回路和电气回路的工作特点,分析多余物来源和典型故障模式,结合近年来质量问题数据统计,采用故障树法(Fault Tree Analysis)和矩阵图法(Matrix Diagram),对从设计至飞行的全生命周期内多余物引入模式进行识别和评定,梳理了设计、工艺和过程控制三方面的防控措施,改进了油液加注环节,建立了较为完善的多余物防控体系,为确保产品质量奠定了基础。 展开更多
关键词 电液伺服系统 多余物防控 可靠性 研究
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Multicenter Randomized Double-Blind Controlled Clinical Study of Huoxue Tongluo Recipe(活血通络方)External Washing in the Treatment of Chemotherapy-Induced Peripheral Neuropathy 预览
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作者 张栋 何斌 +1 位作者 孙凌云 杨宇飞 《世界中西医结合杂志(英文)》 2020年第1期9-17,共9页
Objective: To objectively evaluate the efficacy of Huoxue Tongluo Recipe(活血通络方) in the treatment of chemotherapy-induced peripheral neuropathy(CIPN).Methods: A multicenter, randomized, double-blind, block, and pa... Objective: To objectively evaluate the efficacy of Huoxue Tongluo Recipe(活血通络方) in the treatment of chemotherapy-induced peripheral neuropathy(CIPN).Methods: A multicenter, randomized, double-blind, block, and parallel-controlled study was conducted in which 184 subjects who met the inclusion criteria were randomized into a trial group(92 cases), a control group(46 cases), a placebo group(46 cases) at a 2:1:1 ratio, respectively.Huoxue Tongluo Recipe(活血通络方) granules, Huangqi Guizhi Wuwu Decoction(黄芪桂枝五物汤) instant granules, placebo instant granules were given for hand and foot soaking, with water temperature 38 ℃-45 ℃, soaking for 20 minutes and the intervention time was 14 days.Results:(1) The total effective test drug was 41.30%, the control group was 32.61%, and the placebo group was 32.61%.There was no significant difference in the efficiency of the 3 groups by CMH chi-square test(P>0.05);(2) In the statistics of previous chemotherapy regimens including oxaliplatin or paclitaxel as stratification factors, the overall efficiency of the trial group was significantly different from the other 2 groups.Conclusion: Huoxue Tongluo Recipe(活血通络方) external washing can improve the peripheral nerve injury caused by chemotherapy to some extent, especially in patients with previous chemotherapy regimen including oxaliplatin and paclitaxel. 展开更多
关键词 Huoxue Tongluo Recipe(活血通络方) peripheral nerve injury CHEMOTHERAPY clinical Study
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从“学习”到“问学”:中国教育理性的文化回归之契机 预览
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作者 郑云丹 赵伟黎 《湖南师范大学教育科学学报》 CSSCI 北大核心 2020年第1期17-23,共7页
教育理性意指思考教育的特定思维方式,不同国家和历史时期的教育文化、形态和制度对应着不同的显性教育理性。通过梳理21世纪西方现代教育理性从“学习”到“问学”(study)的转变,从中可以看出,中国的传统文化哲学可为正在全球兴起的“... 教育理性意指思考教育的特定思维方式,不同国家和历史时期的教育文化、形态和制度对应着不同的显性教育理性。通过梳理21世纪西方现代教育理性从“学习”到“问学”(study)的转变,从中可以看出,中国的传统文化哲学可为正在全球兴起的“问学”理性的建构提供丰富的理性文化基础和空间。换而言之,西方当下的“问学”教育理性转向实则为中国教育理性的文化回归提供了一个历史性的契机。 展开更多
关键词 教育理性 教学 学习 问学 中国教育理性回归
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家庭教育何以可能:从书斋、私塾到智慧家庭学习环境 预览
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作者 王运武 田佳欣 +1 位作者 彭梓涵 张尧 《未来与发展》 2020年第1期33-41,共9页
在人类历史长河中,家庭教育曾经发挥了极其重要的作用。中国传统文化非常重视家庭教育,但是随着私塾、书院、现代化学校的兴起与发展,家庭教育的重要性受到挑战。新时代家庭教育的重要性引发了人们的热议,家庭教育面还临着一些亟待解决... 在人类历史长河中,家庭教育曾经发挥了极其重要的作用。中国传统文化非常重视家庭教育,但是随着私塾、书院、现代化学校的兴起与发展,家庭教育的重要性受到挑战。新时代家庭教育的重要性引发了人们的热议,家庭教育面还临着一些亟待解决的突出问题。家庭教育起源于史前家庭,家庭教育的内涵赋予了时代的特征,随着时代的发展而变迁。家庭学习环境的历史变迁,先后经历了史前家庭学习环境、古代家庭学习环境、近代家庭学习环境、现代家庭学习环境,未来将趋向于智慧家庭学习环境。从书斋、私塾到现代书房,再到智慧家庭学习环境,人类对家庭学习环境的需求越来越高。未来的家庭教育,需要掀起"书房革命",实现家家户户有书房。以FAMILY-SMART概念模型为基础,规划与设计智慧家庭学习环境,为家庭成员营造智慧、舒适、便捷、个性的家庭学习空间,形成浓厚的家庭学习氛围。 展开更多
关键词 家庭教育 书斋 书房 智慧家庭学习环境 终身教育
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Endothelial progenitor cells,potential biomarkers for diagnosis and prognosis of ischemic stroke:protocol for an observational case-control study 预览
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作者 Kamini Rakkar Othman Othman +2 位作者 Nikola Sprigg Philip Bath Ulvi Bayraktutan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第7期1300-1307,共8页
Ischemic stroke is a devastating,life altering event which can severely reduce patient quality of life.Despite years of research there have been minimal therapeutic advances.Endothelial progenitor cells(EPCs),stem cel... Ischemic stroke is a devastating,life altering event which can severely reduce patient quality of life.Despite years of research there have been minimal therapeutic advances.Endothelial progenitor cells(EPCs),stem cells involved in both vasculogenesis and angiogenesis,may be a potential therapeutic target.After a stroke,EPCs migrate to the site of ischemic injury to repair cerebrovascular damage,and their numbers and functional capacity may determine patients'outcome.This study aims to determine whether the number of circulating EPCs and their functional aspects may be used as biomarkers to identify the type(cortical or lacunar)and/or severity of ischemic stroke.The study will also investigate if there are any differences in these characteristics between healthy volunteers over and under 65 years of age.100 stroke patients(50 lacunar and 50 cortical strokes)will be recruited in this prospective,observational case-controlled study.Blood samples will be taken from stroke patients at baseline(within 48 hours of stroke)and days 7,30 and90.EPCs will be counted with flow cytometry.The plasma levels of pro-and anti-angiogenic factors and inflammatory cytokines will also be determined.Outgrowth endothelial cells will be cultured to be used in tube formation,migration and proliferation functional assays.Primary outcome is disability or dependence on day 90 after stroke,assessed by the modified Rankin Scale.Secondary outcomes are changes in circulating EPC numbers and/or functional capacity between patient and healthy volunteers,between patient subgroups and between elderly and young healthy volunteers.Recruitment started in February 2017,167 participants have been recruited.Recruitment will end in November 2019.West Midlands-Coventry&Warwickshire Research Ethics Committee approved this study(REC number:16/WM/0304)on September8,2016.Protocol version:2.0.The Bayraktutan Dunhill Medical Trust EPC Study was registered in ClinicalTrials.gov(NCT02980354)on November 15,2016.This study will determine whether the number of EPCs ca 展开更多
关键词 ageing biomarkers cortical stroke endothelial progenitor cells ischemic stroke lacunar stroke observational study stem cells
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Compression analysis of the gray and white matter of the spinal cord 预览
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作者 Norihiro Nishida Fei Jiang +7 位作者 Junji Ohgi Akihiro Tanaka Yasuaki Imajo Hidenori Suzuki Masahiro Funaba Takashi Sakai Itsuo Sakuramoto Xian Chen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第7期1344-1349,共6页
The spinal cord is composed of gray matter and white matter.It is well known that the properties of these two tissues differ considerably.Spinal diseases often present with symptoms that are caused by spinal cord comp... The spinal cord is composed of gray matter and white matter.It is well known that the properties of these two tissues differ considerably.Spinal diseases often present with symptoms that are caused by spinal cord compression.Understanding the mechanical properties of gray and white matter would allow us to gain a deep understanding of the injuries caused to the spinal cord and provide information on the pathological changes to these distinct tissues in several disorders.Previous studies have reported on the physical properties of gray and white matter,however,these were focused on longitudinal tension tests.Little is known about the differences between gray and white matter in terms of their response to compression.We therefore performed mechanical compression test of the gray and white matter of spinal cords harvested from cows and analyzed the differences between them in response to compression.We conducted compression testing of gray matter and white matter to detect possible differences in the collapse rate.We found that increased compression(especially more than 50%compression)resulted in more severe injuries to both the gray and white matter.The present results on the mechanical differences between gray and white matter in response to compression will be useful when interpreting findings from medical imaging in patients with spinal conditions. 展开更多
关键词 biomechanical study cervical spondylotic myelopathy collapse rate compression gray matter mechanical properties spinal cord injury white matter
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Development of a prognostic model for one-year surgery risk in Crohn’s disease patients:A retrospective study 预览
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作者 Jia-Yin Yao Yi Jiang +3 位作者 Jia Ke Yi Lu Jun Hu Min Zhi 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第5期524-534,共11页
BACKGROUND Accelerated therapeutic treatment should be considered in patients with progressive Crohn’s disease(CD)to prevent complications as well as surgery.Therefore,screening for risk factors and predicting the ne... BACKGROUND Accelerated therapeutic treatment should be considered in patients with progressive Crohn’s disease(CD)to prevent complications as well as surgery.Therefore,screening for risk factors and predicting the need for early surgery are of great importance in clinical practice.AIM To establish a model to predict CD-related early surgery.METHODS This was a retrospective study collecting data from CD patients diagnosed at our inflammatory bowel disease center from January 1,2012 to December 31,2016.All data were randomly stratified into a training set and a testing set at a ratio of 8:2.Multivariable logistic regression analysis was conducted with receiver operating characteristic curves constructed and areas under the curve calculated.This model was further validated with calibration and discrimination estimated.A nomogram was finally developed.RESULTS A total of 1002 eligible patients were enrolled with a mean follow-up period of 53.54±13.10 mo.In total,24.25%of patients received intestinal surgery within 1 year after diagnosis due to complications or disease relapse.Disease behavior(B2:OR[odds ratio]=6.693,P<0.001;B3:OR=14.405,P<0.001),smoking(OR=4.135,P<0.001),body mass index(OR=0.873,P<0.001)and C-reactive protein(OR=1.022,P=0.001)at diagnosis,previous perianal(OR=9.483,P<0.001)or intestinal surgery(OR=8.887,P<0.001),maximum bowel wall thickness(OR=1.965,P<0.001),use of biologics(OR=0.264,P<0.001),and exclusive enteral nutrition(OR=0.089,P<0.001)were identified as independent significant factors associated with early intestinal surgery.A prognostic model was established and further validated.The receiver operating characteristic curves and calculated areas under the curves(94.7%)confirmed an ideal predictive ability of this model with a sensitivity of 75.92%and specificity of 95.81%.A nomogram was developed to simplify the use of the predictive model in clinical practice.CONCLUSION This prognostic model can effectively predict 1-year risk of CD-related intestinal surgery,which will assist in screening p 展开更多
关键词 Crohn’s disease Prognostic model NOMOGRAM Early surgery Inflammatory bowel disease Retrospective study
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基于数据分析的大学生宿舍管理工作思考——以常熟理工学院为例 预览
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作者 宋佳玲 陆镜伊 孙士现 《教育教学论坛》 2020年第4期28-30,共3页
宿舍是学风建设的最小单元体,是学院学风的集中体现。通过对现有数据的分析研究,掌握宿舍环境对学生学习的影响规律,良好的宿舍环境对学生的学习成长起着重要作用。学校通过完善管理制度、加强服务意识、加快宿舍文化建设,共同推进宿舍... 宿舍是学风建设的最小单元体,是学院学风的集中体现。通过对现有数据的分析研究,掌握宿舍环境对学生学习的影响规律,良好的宿舍环境对学生的学习成长起着重要作用。学校通过完善管理制度、加强服务意识、加快宿舍文化建设,共同推进宿舍学风的建设。 展开更多
关键词 宿舍环境 学业 数据分析 文化建设
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淋巴水肿的治疗进展 预览
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作者 刘凤 《中国社区医师》 2020年第1期5-6,共2页
为了降低临床术后淋巴水肿的发生,有效提升患者的长期生存质量,提出有效的临床治疗预防策略。国内外研究学者对于临床术后淋巴水肿问题进行大量研究,认为早期发现淋巴水肿尤为重要,予以早期治疗更能够降低淋巴水肿并发症的发生率。文章... 为了降低临床术后淋巴水肿的发生,有效提升患者的长期生存质量,提出有效的临床治疗预防策略。国内外研究学者对于临床术后淋巴水肿问题进行大量研究,认为早期发现淋巴水肿尤为重要,予以早期治疗更能够降低淋巴水肿并发症的发生率。文章通过搜集查阅大量国内外临床有关淋巴水肿治疗的文献,对其研究进展进行如下综述。 展开更多
关键词 淋巴水肿 治疗 研究
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Cross-sectional Seroprevalence and Genotype of Hepatitis E Virus in Humans and Swine in a High-density Pig-farming Area in Central China
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作者 Yilin Shu Yameng Chen +7 位作者 Sheng Zhou Shoude Zhang Qin Wan Changcai Zhu Zhijiang Zhang Hailong Wu Jianbo Zhan Ling Zhang 《中国病毒学:英文版》 CAS CSCD 2019年第4期367-376,共10页
Hepatitis E virus(HEV)infection is a common public health problem in developing countries.However,the current prevalence of HEV and the relationship of HEV genotype between swine and human within high-density pig-farm... Hepatitis E virus(HEV)infection is a common public health problem in developing countries.However,the current prevalence of HEV and the relationship of HEV genotype between swine and human within high-density pig-farming areas in central China are still inadequately understood.Here,cross-sectional serological and genotypic surveys of HEV among the 1232 general population,273 workers occupationally exposed to swine,and 276 pigs in a high-density pig-breeding area,were undertaken by ELISA and nested RT-PCR methods.Anti-HEV IgG was detected in 26.22%of general population and 48.35%of occupational workers.The prevalence of swine serum HEV-Ag was 6.52%.The prevalence of anti-HEV IgG was significantly higher among the workers occupationally exposed to swine than among the general population.An increased HEV seropositivity risk among the general population was associated with either being a peasant or male and was very strongly associated with the increase of age.Among the occupationally exposed group,the prevalence of anti-HEV IgG antibodies increased with age and working years.Among the 30 HEV-IgM-positive people,the infection rates of clerks in the public,peasants,pork retailers,and pig farmers were higher than those of others.A phylogenetic analysis revealed that all the isolates belonged to subgenotype 4d,and four people and four pigs shared 97.04%-100%sequence homology.This study revealed a high HEV seroprevalence among the general population and workers occupationally exposed to swine in the Anlu City,and supports the notion that swine are a source of human HEV infection. 展开更多
关键词 Hepatitis E virus(HEV) Seroepidemiological STUDY ZOONOSIS CROSS-SECTIONAL STUDY GENOTYPE
The effect of long-term traditional Chinese medicine treatment on disease-free survival of postoperative stage I-III lung cancer patients:a retrospective cohort study 预览
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作者 Su-Tong Liu Su-Fang Zhang +6 位作者 Kai-Qi Su Ying-Bin Luo Zhi-Hong Fang Yuan Fang Jing Xu Jian-Chun Wu Yan Li 《TMR传统医学研究》 2019年第2期91-98,共8页
Objective:Traditional Chinese medicine(TCM)has been extensively used as one of popular alternative therapies for several cancers.However,it remains unclear whether TCM treatment is associated with longer survival in l... Objective:Traditional Chinese medicine(TCM)has been extensively used as one of popular alternative therapies for several cancers.However,it remains unclear whether TCM treatment is associated with longer survival in lung cancer patients.In this study,we explored the effect of long-term TCM treatment on patients with different stages of lung cancer.Methods:All information of lung cancer patients with stage I-III disease from January 2007 to September 2015 was collected for this retrospective cohort study.Those who were treated with TCM after surgery were divided into TCM group and the others were into the non-TCM group(control group).All patients were regularly followed up by clinic appointment or phone,and all survival data were collected from databases after the last follow-up in October 2017.Results:A total of 575 patients were included in this study,with 299 patients in the TCM group and 276 in the control group.For all patients,5-year disease-free survival(DFS)was 62.2% in TCM group and 42.1% in the control group,and 6-year DFSs were 51.8% and 35.4%,respectively(HR=0.51,95% CI:0.40 to 0.66,log-rank P≤0.001).For patients with stage I,5-year DFSs were 83.7%(TCM group)and 57.5%(control group)and 6-year DFSs were 73.7% and 51.9%,respectively(HR=0.30,95% CI:0.18 to 0.50,log-rank P≤0.001).For patients with stage II in the TCM group and the control group,5-year DFSs were 59.4% and 17.6% and 6-year DFSs were 44.7% and 17.6%,respectively(HR=0.31,95% CI:0.19 to 0.52,log-rank P≤0.001),and for patients with stage III,5-year and 6-year DFSs in the TCM group were 18.7% and 12.5% compared with 28.4% and 20.3% in the control group(HR=1.06,95% CI:0.72 to 1.56,log-rank P=0.76).Conclusions:This study demonstrated that long-term TCM treatment as an adjuvant therapy is able to improve the DFS of postoperative stage I-III lung cancer patients,especially in patients with stage I and II disease.However,these observational findings need being validated by large sample randomized controlled trials. 展开更多
关键词 TRADITIONAL Chinese medicine LUNG cancer Disease-free survival RETROSPECTIVE STUDY COHORT STUDY
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初中化学专题复习教学模式研究 预览
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作者 冯克新 《科技视界》 2019年第34期275-276,共2页
初中毕业班化学复习教学很重要,我们通过听评课研究初中化学单元复习教学时存在的问题,开展多种形式的课题研究活动,探讨解决问题的方法,并把研究成果应用于初中化学课堂教学实践之中。
关键词 化学 专题复习 教学模式 研究
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