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MSCT与MRI技术在鉴别结直肠癌术前T、N分期的诊断价值 预览 被引量:1
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作者 刘华 边芳 翟冬枝 《中国CT和MRI杂志》 2019年第4期109-111,共3页
目的探讨多层螺旋CT扫描(MSCT)与MRI在鉴别结直肠癌术前T、N分期的诊断价值。方法选取2016年2月-2017年10月本院收治的60例结直肠癌患者为研究对象,均于术前1周行MSCT、MRI扫描检查,以术后病理分期结果为金标准,评估MSCT与MRI在鉴别结... 目的探讨多层螺旋CT扫描(MSCT)与MRI在鉴别结直肠癌术前T、N分期的诊断价值。方法选取2016年2月-2017年10月本院收治的60例结直肠癌患者为研究对象,均于术前1周行MSCT、MRI扫描检查,以术后病理分期结果为金标准,评估MSCT与MRI在鉴别结直肠癌术前T、N分期的诊断价值。结果以术后病理分期结果为金标准,MRI诊断结直肠癌患者术前T、N分期的符合率较MSCT的明显高,差异有统计学意义(P<0.05);典型病例图像分析结果提示MSCT和MRI在结直肠癌患者术前分期诊断中均有明确应用价值。结论 MRI在鉴别结直肠癌术前T、N分期的诊断中与术后病理分期结果的符合率较MSCT明显高,前者在结直肠癌患者术前T、N分期诊断中的应用价值更高。 展开更多
关键词 结直肠癌 MSCT MRI T分期 N分期
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STAGE在雷达系统显控软件测试中的应用 预览
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作者 赵进科 杨贝松 王海明 《电子产品可靠性与环境试验》 2019年第A01期131-135,共5页
对雷达系统显控软件的测试方法进行了分析,针对航迹注入测试架构中存在的难题进行了深入的探讨,研究了一种基于STAGE软件的雷达系统显控软件的测试方法。该方法通过共享内存的方式实现STAGE与被测软件之间的数据交互,借助STAGE软件的图... 对雷达系统显控软件的测试方法进行了分析,针对航迹注入测试架构中存在的难题进行了深入的探讨,研究了一种基于STAGE软件的雷达系统显控软件的测试方法。该方法通过共享内存的方式实现STAGE与被测软件之间的数据交互,借助STAGE软件的图形用户界面功能,快速地设计测试场景,能够很大程度上提高被测软件测试的充分性,提升测试效率。 展开更多
关键词 養达系统 显控软件 软件测试 STAGE
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三叠系的阶与牙形刺生物地层 预览
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作者 王成源 郎嘉彬 《世界地质》 CAS 2019年第1期20-33,共14页
三叠纪的3统7阶时限相差极大,晚三叠世的时限最长。牙形刺是三叠纪生物地层的主导化石门类,在生物地层划分中的作用越来越重要。中国三叠纪牙形刺生物地层的牙形刺带已达50带,还会增加,特别是在晚三叠世。阶是全球的地质年代单位,应全... 三叠纪的3统7阶时限相差极大,晚三叠世的时限最长。牙形刺是三叠纪生物地层的主导化石门类,在生物地层划分中的作用越来越重要。中国三叠纪牙形刺生物地层的牙形刺带已达50带,还会增加,特别是在晚三叠世。阶是全球的地质年代单位,应全球统一,使用共同的名称和定义。不要按国别建阶,更不能按岩相或生物群建阶。陆相地层不适宜建阶,陆相地层的阶名也不宜再使用。 展开更多
关键词 陆相阶 牙形刺 生物地层
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Pattern of Gynaecological Malignancies in a Tertiary Care Hospital 预览
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作者 Sayma Afroz Gulshan Ara Fahmida Sultana 《妇产科期刊(英文)》 2019年第4期449-457,共9页
Background: Gynaecological malignancies are the second most common cancer of females after cancer breast. Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and m... Background: Gynaecological malignancies are the second most common cancer of females after cancer breast. Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. Carcinoma cervix is the commonest gynaecological malignancy in developing countries while in developed countries, ovarian cancer is the commonest. Comprehensive statistics on gynecologic malignancies reported from Bangladesh are deficient. This study was performed to ascertain the profile of gynecologic cancers reported at our center regarding demography, the frequency of involvement at various sites, clinical presentation, incidence, histologic subtypes and stage at presentation. Methods: This is a retrospective study where the records of the Departments of Gynecology and Pathology at Enam Medical College & Hospital, Dhaka, Bangladesh were retrospectively reviewed to identify all cases of Gynecologic malignancies and to determine the pattern of gynaecological malignancies identified between January 2015 and December, 2018. Results: Cervical cancer (53%) was the most common gynaecological malignancy, followed by ovarian cancer (29%), uterine cancer (8%), vulvar cancer (5%) and gestational trophoblastic neoplasm (GTN 5%). In the case of cervical and ovarian cancer the most common age group was 41 - 50 years and gestational trophoblastic neoplasm (GTN). The majority of patients presented at the ages of 31 - 40 years while uterine cancer presented in the elderly (>60 years). Among the patients studied 88% were multiparous. Of the cervical cancer cases, 96.22% was squamous cell carcinoma and commonest presenting complains were contact bleeding (33.96%) and excessive and irregular menstruation (26.41%). Among ovarian tumor cases 69% had epithelial while 31% had non-epithelial cancer and predo& 展开更多
关键词 GYNAECOLOGICAL MALIGNANCIES HISTOPATHOLOGY STAGE BANGLADESH
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Monoenergetic proton beam accelerated by single reflection mechanism only during hole-boring stage
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作者 Wenpeng Wang Cheng Jiang +5 位作者 Shasha Li Hao Dong Baifei Shen Yuxin Leng Ruxin Li Zhizhan Xu 《高功率激光科学与工程:英文版》 CAS CSCD 2019年第3期222-227,共6页
Multidimensional instabilities always develop with time during the process of radiation pressure acceleration,and are detrimental to the generation of monoenergetic proton beams.In this paper,a sharp-front laser is pr... Multidimensional instabilities always develop with time during the process of radiation pressure acceleration,and are detrimental to the generation of monoenergetic proton beams.In this paper,a sharp-front laser is proposed to irradiate a triple-layer target(the proton layer is set between two carbon ion layers)and studied in theory and simulations.It is found that the thin proton layer can be accelerated once to hundreds of MeV with monoenergetic spectra only during the hole-boring(HB)stage.The carbon ions move behind the proton layer in the light-sail(LS)stage,which can shield any further interaction between the rear part of the laser and the proton layer.In this way,proton beam instabilities can be reduced to a certain extent during the entire acceleration process.It is hoped such a mechanism can provide a feasible way to improve the beam quality for proton therapy and other applications. 展开更多
关键词 proton acceleration radiation acceleration sharp-front laser hole-boring stage light-sail stage
Se7en——大连NA stage Livehouse
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作者 潘飞 王植 +1 位作者 韩冬 朱钟晖 《中国建筑装饰装修》 2019年第6期82-87,共6页
音乐是最直接的艺术形式。空间也有叙事性的节奏,音乐在引领这个节奏。创作的激发点是贝多芬第七交响曲,它有力,且直击灵魂。有四个部分组合这个空间:筒壁,拱券,斜屋,长台。音乐与空间,一虚一实,共同舞蹈。空间承接着音乐,有力度的变化... 音乐是最直接的艺术形式。空间也有叙事性的节奏,音乐在引领这个节奏。创作的激发点是贝多芬第七交响曲,它有力,且直击灵魂。有四个部分组合这个空间:筒壁,拱券,斜屋,长台。音乐与空间,一虚一实,共同舞蹈。空间承接着音乐,有力度的变化,有戏剧性的冲突。音乐可以触摸,音乐可以成为现实。触摸音乐,触摸现实。 展开更多
关键词 城市音乐 Se7en NA STAGE Livehouse
Implementing of the JPWSPC method in RIV1H for unsteady flow modeling in general river networks 预览
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作者 Dejun Zhu Yongcan Chen 《国际泥沙研究:英文版》 SCIE 2019年第4期379-386,共8页
RIV1H is the stand-alone hydraulic program of CE-QUAL-RIV1, a longitudinal hydraulic and water quality model developed by U.S. Army Corps of Engineers Waterways Experiment Station. RIV1H solves the Saint-Venant equati... RIV1H is the stand-alone hydraulic program of CE-QUAL-RIV1, a longitudinal hydraulic and water quality model developed by U.S. Army Corps of Engineers Waterways Experiment Station. RIV1H solves the Saint-Venant equations using the widely accepted four-point implicit Preissmann scheme, and the resulting nonlinear equations are solved using the Newton-Raphson method. RIV1H is capable of simulating multiple branches, and in-stream hydraulic control structures. It treats tributary networks using a double sweep algorithm based on upstream ordering of the branches. It treats the control structures following a downstream solution order, which also is based on the upstream ordering of the branches. Since an upstream ordering cannot be achieved for looped networks, RIV1H is only applicable to non-looped tributary networks. In the current study, the junction-point water stage prediction and correction (JPWSPC) method is extended to take into account the control structures and the method is used to improve the RIV1H model, enabling it to be applied to both non-looped and looped networks with in-stream hydraulic control structures. The JPWSPC method makes the linear equation system for each segment complete while maintaining the banded property, thus the system can be independently and efficiently solved. It has the advantages to be efficient, robust, and very suitable for parallel computing. The improved RIV1H model was tested using two idealized networks and the results demonstrated the success of the improvement. 展开更多
关键词 RIV1H Numerical hydraulic model RIVER network Control structure Junction-point water STAGE prediction and CORRECTION
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论清代坊本弹词的雅化 预览
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作者 盛志梅 《苏州教育学院学报》 2019年第4期36-42,共7页
清代弹词是一种融娱乐性、文学性、商业性于一体的文学,根据生产方式的不同,可以分为书场弹词、书坊(坊本)弹词、书斋(案头)弹词。清代弹词在发展过程中出现了雅化的趋势。其中,坊本弹词的雅化主要有三个特征:以抢占市场为目的的题材雅... 清代弹词是一种融娱乐性、文学性、商业性于一体的文学,根据生产方式的不同,可以分为书场弹词、书坊(坊本)弹词、书斋(案头)弹词。清代弹词在发展过程中出现了雅化的趋势。其中,坊本弹词的雅化主要有三个特征:以抢占市场为目的的题材雅化,以扩大市场为目的的形式雅化和以迎合政府文禁为目的的主题雅化。坊本弹词的雅化是清代文人弹词创作的一个主要诱因,是弹词创作由书场走向书斋的一个必要中介。 展开更多
关键词 坊本弹词 弹词 书场 雅化 清代 书坊 坊刻本
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Hepatitis C virus cure with direct acting antivirals:Clinical,economic,societal and patient value for China 预览
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作者 Qing Xie Jian-Wei Xuan +4 位作者 Hong Tang Xiao-Guang Ye Peng Xu I-Heng Lee Shan-Lian Hu 《世界肝病学杂志:英文版(电子版)》 2019年第5期421-441,共21页
About 10 million people in China are infected with hepatitis C virus(HCV),with the seroprevalence of anti-HCV in the general population estimated at 0.6%.Delaying effective treatment of chronic hepatitis C(CHC)is asso... About 10 million people in China are infected with hepatitis C virus(HCV),with the seroprevalence of anti-HCV in the general population estimated at 0.6%.Delaying effective treatment of chronic hepatitis C(CHC)is associated with liver disease progression,cirrhosis,hepatocellular carcinoma,and liver-related mortality.The extrahepatic manifestations of CHC further add to the disease burden of patients.Managing CHC-related advanced liver diseases and systemic manifestations are costly for both the healthcare system and society.Loss of work productivity due to reduced well-being and quality of life in CHC patients further compounds the economic burden of the disease.Traditionally,pegylatedinterferon plus ribavirin(PR)was the standard of care.However,a substantial number of patients are ineligible for PR treatment,and only 40%–75%achieved sustained virologic response.Furthermore,PR is associated with impairment of patient-reported outcomes(PROs),high rates of adverse events,and poor adherence.With the advent of direct acting antivirals(DAAs),the treatment of CHC patients has been revolutionized.DAAs have broader eligible patient populations,higher efficacy,better PRO profiles,fewer adverse events,and better adherence rates,thereby making it possible to cure a large proportion of all CHC patients.This article aims to provide a comprehensive evaluation on the value of effective,curative hepatitis C treatment from the clinical,economic,societal,and patient experience perspectives,with a focus on recent data from China,supplemented with other Asian and international experiences where China data are not available. 展开更多
关键词 Hepatitis C VALUE of CURE Sustained VIROLOGIC response End stage liver disease Prevention of transmission COST-EFFECTIVENESS Productivity Societal VALUE Patient-reported outcomes
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凝血酶原时间与肝促凝血活酶试验在诊断慢性乙型病毒性肝炎肝纤维化分期中的价值
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作者 秦颖 《中国基层医药》 CAS 2019年第12期1472-1475,共4页
目的探讨凝血酶原时间(PT)与肝促凝血活酶试验(HPT)在诊断慢性乙型病毒性肝炎患者肝纤维化分期中的价值.方法整取抽样2015年1月至2016年1月运城市中心医院慢性乙型病毒性肝炎患者76例,检测不同肝纤维化分期患者血浆PT及HPT,测定其敏感... 目的探讨凝血酶原时间(PT)与肝促凝血活酶试验(HPT)在诊断慢性乙型病毒性肝炎患者肝纤维化分期中的价值.方法整取抽样2015年1月至2016年1月运城市中心医院慢性乙型病毒性肝炎患者76例,检测不同肝纤维化分期患者血浆PT及HPT,测定其敏感度、特异度及准确率,分析PT与HPT指标在肝纤维化分期中的临床价值.结果慢性乙型病毒性肝炎患者中,随着肝纤维化严重程度的增加,PT、HPT水平明显升高,其中S4期PT水平[(14.86±0.96)s]与S1[(13.31±0.49)s]、S2[(13.43±0.52)s]、S3[(13.66±0.53)s]期比较差异有统计学意义(P<0.05);S3期HPT水平[(19.33±1.14)s]与S1[(17.74±0.82)s]、S2期[(18.12±0.95)s]比较差异有统计学意义(P<0.05);S4期HPT水平[(20.27±1.39)s]与S1[(17.74±0.82)s]、S2[(18.12±0.95)s]、S3期[(19.33±1.14)s]比较差异有统计学意义(P<0.05);经绘制ROC曲线分析,PT、HPT对肝纤维化分期≥S2、S4的敏感度、特异度、准确率均较高.结论PT、HPT敏感度、特异度均较高,在慢性乙型病毒性肝炎患者肝纤维化分期中具有良好的临床诊断价值. 展开更多
关键词 肝炎 乙型 慢性 肝硬化 凝血酶原时间 肝促凝血活酶时间 分期 肝储备功能 对比敏感度
H infinity Control for Sandwiched Maglev Stage with Dynamic Damping 预览
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作者 Ningran Song Shuyuan Ma +2 位作者 Zongqing Zhang Shansi Zhang Changmeng Liu 《北京理工大学学报:英文版》 EI CAS 2019年第2期218-225,共8页
An H infinity(H∞)controller for a sandwiched maglev positioning stage is proposed.The maglev positioning stage has a special structure:a sandwiched maglev stage,consisting of repulsive linear motors and attractive li... An H infinity(H∞)controller for a sandwiched maglev positioning stage is proposed.The maglev positioning stage has a special structure:a sandwiched maglev stage,consisting of repulsive linear motors and attractive linear motors,which have better levitation performance.Forces on the sandwiched maglev stage are analyzed and modeled.The positioning controller is designed based on the feedback linearized model with a dynamic damping system.The design of the H infinity controller for stage positioning is derived as a series of linear matrix inequalities(LMIs)which are efficiently solved in Matlab.The proposed controller and its effectiveness is demonstrated compared to PID method. 展开更多
关键词 sandwiched structure POSITIONING STAGE MAGLEV technology H infinity(H∞)control
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Combination of fire needle and filiform needle for frozen shoulder in different clinical stages
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作者 高艳 刘美颖 +3 位作者 王爽 陈跃辉 解秸萍 冀美琦 《世界针灸杂志:英文版》 CSCD 2019年第2期119-122,共4页
Objective:To observe the clinical efficacy of fire needle combined with filiform needle for different clinical stage frozen shoulders,and to choose the best treatment opportunity for clinical treatment of frozen shoul... Objective:To observe the clinical efficacy of fire needle combined with filiform needle for different clinical stage frozen shoulders,and to choose the best treatment opportunity for clinical treatment of frozen shoulder.Methods:120 patients with frozen shoulders who met the inclusion criteria were numbered according to the visiting order.They were randomized into control group(60 cases)and treatment group(60 cases)according to the random number table.Both groups were treated with filiform needles once every other day and 3 times a week,and a course of treatment included 6 times and 2 courses were taken.The treatment group was treated by applying a fire needling point bloodletting on the local tender points once a week.Jiānyú(肩髃 LI 15),Jiānliáo(肩髎 TE 14),Jiānzhēn(肩贞 SI 9),Tiáokǒu(条口 ST 38),and local tender points were taken according to different meridian pains.The clinical efficacy of the frozen shoulder patients in the two groups in different clinical stages was compared.The evaluation indicators were scores of pain,joint activity range and activities of daily living,as well as clinical efficacy of traditional Chinese medicine.Results:After treatment,the total scores of hundred-mark five-grade in both groups were significantly higher than those before treatment,and the differences were statistically significant(Treatment group82.02 ± 14.23 vs 43.37 ± 22.10,Control group 66.80 ± 18.98 vs 42.67 ± 23.03,both P<0.01),and the total score of the treatment group was significantly higher than the control group(P<0.01).The hundred-mark five-grade assessment scores after treatment in the treatment group during the frozen stage were significantly higher than the control group(77.2± 14.40 vs 68.43 ± 16.94,P<0.01);as to the clinical efficacy,the total effective rate of the treatment group was higher than the control group,and the difference was statistically significant(91.67% vs 76.67%,P<0.01);The total effective rate of the control group in the acute stage and functional recovery stage was co 展开更多
关键词 PERIARTHRITIS of the SHOULDER Clinical STAGE Fire NEEDLE FILIFORM NEEDLE
A Critical Stage
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作者 Li Qingyan 《北京周报:英文版》 2019年第39期30-31,共2页
With U.S.-Taliban talks scuttled, more challenges lie ahead for the Afghan peace process Soon after coming to power in 2017, U.S. President Donald Trump unveiled his new strategy in Afghanistan and South Asia, hoping ... With U.S.-Taliban talks scuttled, more challenges lie ahead for the Afghan peace process Soon after coming to power in 2017, U.S. President Donald Trump unveiled his new strategy in Afghanistan and South Asia, hoping to change the passive U.S. 展开更多
关键词 A CRITICAL STAGE
A NEW STAGE
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作者 Yu Lintao 《北京周报:英文版》 2019年第19期12-15,共4页
The Belt and Road Initiative advances after years of hard work and development Despite some governments and people in the West conjuring up arguments of 'neocolonial-ism' or a 'debt trap' to smear the ... The Belt and Road Initiative advances after years of hard work and development Despite some governments and people in the West conjuring up arguments of 'neocolonial-ism' or a 'debt trap' to smear the Belt and Road Initiative. 展开更多
关键词 BRF A NEW STAGE World
Biomass Characteristics of the Arbor Layer in Different Stands of the Evergreen Broad-Leaved Forest 预览
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作者 ZENG Zhangquan TANG Hong +4 位作者 LI Minghong YANG Rui ZHANG Canming WANG Ying ZENG Xiahui 《景观研究:英文版》 2019年第3期105-106,109共3页
In this paper, the Pinus massoniana forest in the early stage of succession, the coniferous broad-leaved mixed forest in the middle stage of succession, and the evergreen broad-leaved forest in the late stage of succe... In this paper, the Pinus massoniana forest in the early stage of succession, the coniferous broad-leaved mixed forest in the middle stage of succession, and the evergreen broad-leaved forest in the late stage of succession were studied, and the biomass and its spatial distribution characteristics of the tree layer in different succession stages of the ecosystem were discussed. The results showed that the biomass of the arbor layer was the highest in the evergreen broad-leaved forest, which was 292.51 t/ hm2, followed by the coniferous and broad-leaved mixed forest, which was 206.87 t/hm2, and the Pinus massoniana forest, which was 171.76 t/hm2. The biomass of trunks accounted for the largest proportion in the total biomass of the arbor layer, which reduced from the Pinus massoniana forest to the evergreen broad-leaved forest. The proportion of the biomass of roots in the total biomass of the arbor layer increased from the Pinus massoniana forest to the evergreen broad-leaved forest. The biomass of the diameter class above 20 cm in the Pinus massoniana forest, the coniferous and broad-leaved mixed forest and the evergreen broad-leaved forest accounted for a large proportion of total biomass. 展开更多
关键词 EVERGREEN broad-leaved FOREST Biomass of the ARBOR LAYER Mid-subtropics SUCCESSION stage
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试论当代新闻文体研究的三个阶段 预览
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作者 李娟 《宿州学院学报》 2019年第9期53-57,共5页
作为新闻学研究的重要组成部分,当代新闻文体研究可以分为三个重要阶段。20世纪80年代是第一阶段,面对历史积弊,一批代表性学者尝试从理论与实践两个维度展开研究,从而呼应新闻改革的现实诉求。20世纪90年代是第二阶段,其显著特征是引... 作为新闻学研究的重要组成部分,当代新闻文体研究可以分为三个重要阶段。20世纪80年代是第一阶段,面对历史积弊,一批代表性学者尝试从理论与实践两个维度展开研究,从而呼应新闻改革的现实诉求。20世纪90年代是第二阶段,其显著特征是引入文体学的理路与框架,强化新闻文体研究的学术性与理论性,从而重构新闻写作学。21世纪至今是第三阶段,新闻文体研究从内容到方法,呈现出多元化态势,理论性与延展性都较传统有了长足的进步。总体看,当代新闻文体研究的主要问题在于缺乏整合性研究观念,停留在对某一次报道、某一报道体裁的经验总结层面的低水平重复现象比较突出。 展开更多
关键词 新闻文体 新闻写作 新闻学 阶段与特征
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基于高分辨T2WI的影像组学对直肠癌术前分期的应用价值 预览
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作者 王进 李智慧 +1 位作者 沈浮 陆建平 《放射学实践》 北大核心 2019年第11期1251-1254,共4页
目的:探讨基于高分辨T 2WI影像组学在直肠癌术前T分期中的应用价值。方法:回顾性分析2017年1月-2018年12月在上海长海医院经手术病理证实且术前行3T磁共振高分辨T 2WI的直肠癌患者资料。根据病理T分期结果将T1和T2期患者归为未突破肌层... 目的:探讨基于高分辨T 2WI影像组学在直肠癌术前T分期中的应用价值。方法:回顾性分析2017年1月-2018年12月在上海长海医院经手术病理证实且术前行3T磁共振高分辨T 2WI的直肠癌患者资料。根据病理T分期结果将T1和T2期患者归为未突破肌层组,T3和T4期患者归为突破肌层组。在高分辨T 2WI图像上手动勾画病灶ROI后提取影像组学特征,之后采用LASSO算法进行降维选择出对病理T分期有价值的特征。将所选样本按7:3的比例随机分为训练集与验证集进行机器学习,构建支持向量机(SVM)分类器模型,得到训练集和验证集的ROC曲线下面积(AUC)、敏感度、特异度及95%置信区间。结果:纳入病例共154例,男92例,女62例,平均年龄(56.5±10.2)岁,其中T1期26例,T2期41例,T3期76例,T4期11例。训练集106例(未突破肌层组46例,突破肌层组60例),验证集48例(未突破肌层组21例,突破肌层组27例)。LASSO算法筛选出5个与T分期相关特征。得到SVM模型验证集的AUC、95%CI、敏感度及特异度分别为0.730、0.583~0.848、73.1%、66.7%。结论:基于高分辨T 2WI的影像组学SVM模型可以判断直肠癌病灶是否突破固有肌层,对于直肠癌术前T分期具有较高的参考价值。 展开更多
关键词 直肠肿瘤 影像组学 磁共振成像 T分期
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Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/β-catenin in urinary bladder cancer patients 预览
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作者 Niharika Maurya Rinni Singh +4 位作者 Apul Goel Atin Singhai Uday Pratap Singh Vinita Agrawal Minal Garg 《世界临床肿瘤学杂志(英文版)》 2019年第4期166-182,共17页
BACKGROUND Aberrant activation of phosphorylated form of glycogen synthase kinase-3β[pS9GSK-3β(Serine 9 phosphorylation)] is known to trigger Wnt/β-catenin signal cascade but its clinicohistopathological implicatio... BACKGROUND Aberrant activation of phosphorylated form of glycogen synthase kinase-3β[pS9GSK-3β(Serine 9 phosphorylation)] is known to trigger Wnt/β-catenin signal cascade but its clinicohistopathological implications in bladder carcinogenesis remain unknown. AIM To investigate the diagnostic and prognostic relevance of expressions of pS9GSK- 3β,β-catenin and its target genes in the pathobiology of bladder cancer. METHODS Bladder tumor tissues from ninety patients were analyzed for quantitative expression and cellular localization of pS9GSK-3β by immunohistochemical (IHC) staining. Real time-quantitative polymerase chain reaction and IHC were done to check the expression of β-catenin, Cyclin D1, Snail and Slug at transcriptome and protein level respectively. Clinicohistopathological variables were obtained from histology reports, follow up and OPD visits of patients. Expressions of the markers were statistically correlated with these variables to determine their significance in clinical setting. Results were analysed using SPSS 20.0 software.RESULTS Aberrant (low or no membranous/high nuclear/high cytoplasmic) expression of pS9GSK-3β was noted in 51% patients and found to be significantly associated with tumor stage and tumor grade (P = 0.01 and 0.04;Mann Whitney U test). Thirty one percent tumors exhibited aberrant co-expression of pS9GSK-3β and β–catenin proteins and showed strong statistical association with tumor stage, tumor type, smoking/tobacco chewing status (P = 0.01, 0.02 and 0.04, Mann- Whitney U test) and shorter overall survival probabilities of patients (P = 0.02;Kaplan Meier test). Nuclear immunostaining of Cyclin D1 in tumors with altered pS9GSK-3β/β–catenin showed relevance with tumor stage, grade and type. CONCLUSION β–catenin and pS9GSK-3β proteins are identified as markers of diagnostic/prognostic significance in disease pathogenesis. Observed histopathological association of Cyclin D1 identifies it as marker of potential relevance in tumors with altered pS9GSK-3β/β-cateni 展开更多
关键词 PATHOBIOLOGY Target genes Tumor stage and grade Wnt/β–catenin signal CASCADE UROTHELIAL carcinoma of BLADDER
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论荀子教学过程的四个阶段 预览
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作者 周丽威 李栋 杨丽 《延边大学学报:社会科学版》 CSSCI 2019年第2期125-131,144共8页
优秀传统文化是习近平总书记治国理念的重要来源之一。传统文化的继承与发扬离不开对历史文化的深度挖掘与阐释。荀子是先秦杰出的政治家、教育家,而《劝学》则集中阐发了荀子的教育思想。《劝学》作为《荀子》三十二篇的首篇,有其重要... 优秀传统文化是习近平总书记治国理念的重要来源之一。传统文化的继承与发扬离不开对历史文化的深度挖掘与阐释。荀子是先秦杰出的政治家、教育家,而《劝学》则集中阐发了荀子的教育思想。《劝学》作为《荀子》三十二篇的首篇,有其重要的学术地位和价值。作为较早的教学方法论专著,《劝学》较为系统地论述了教学过程的四个阶段,这里将其归纳为教学的起势、顺势、蓄势与破势。在教学的起势阶段,荀子营造了一种后天学习的氛围,并赋予后天教化以终极地位,这是对孔孟“生而知之”教学思想的超越;在教学的顺势阶段,荀子提出了教学应顺环境、顺因果及顺人性,这是一种顺应自然哲学的教学观;在教学的蓄势阶段,荀子强调教学应使学生将积思学相结合,即重积累、肯钻研及善亲师;在教学的破势阶段,荀子间接地阐明了其教学的目的,即培养德才兼备的治世人才,荀子一气呵成地对这种全才、精才作了描述,点亮了全篇,势如破竹。 展开更多
关键词 《劝学》 荀子 教学 阶段
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汉文化大会堂消防给水设计探讨 预览
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作者 贾雪艳 《工程建设与设计》 2019年第8期70-71,83共3页
汉文化大会堂消防给水系统主要包括消火栓系统、固定消防系统、自动喷水灭火系统、雨淋系统和水幕系统。论文以汉文化大会堂消防系统设计为例,阐述了设计中对舞台水消防设计的理解和各消防系统的选择级参数的确定,并提出了有待进一步探... 汉文化大会堂消防给水系统主要包括消火栓系统、固定消防系统、自动喷水灭火系统、雨淋系统和水幕系统。论文以汉文化大会堂消防系统设计为例,阐述了设计中对舞台水消防设计的理解和各消防系统的选择级参数的确定,并提出了有待进一步探讨的问题。 展开更多
关键词 舞台 水消防系统 雨淋系统 水幕系统
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