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RhoA/ROCK信号通路相关疾病的研究进展 预览
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作者 刘建兵 刘敏丽 《海南医学院学报》 CAS 2019年第6期472-476,共5页
RhoA属于RhoGTP亚家族蛋白。RhoA能够激活下游的ROCK激酶,进而影响细胞分子的生成和分泌,并产生相应的生物学效应。这一系列反应构成RhoA/ROCK信号通路。因此该通路的激活和抑制与多种疾病的发生发展密切相关。对其中所涉及的分子机制... RhoA属于RhoGTP亚家族蛋白。RhoA能够激活下游的ROCK激酶,进而影响细胞分子的生成和分泌,并产生相应的生物学效应。这一系列反应构成RhoA/ROCK信号通路。因此该通路的激活和抑制与多种疾病的发生发展密切相关。对其中所涉及的分子机制的研究可能会对临床治疗及疾病的预后有所启发和帮助。本文结合近年来的研究对RhoA/ROCK信号通路所涉及的相关典型疾病进行综述。 展开更多
关键词 RHOA ROCK RhoA/ROCK通路 磷酸化
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Rho/ROCK信号通路与神经可塑性
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作者 陈琪 贾瑞丹 +2 位作者 陈霏霏 杨丽 李怡瑞 《生命的化学》 CAS CSCD 2019年第1期159-164,共6页
在神经网络中,神经可塑性是大脑响应内在和外在刺激的重要特征。越来越多的研究已经阐明了神经可塑性与神经损伤性疾病之间的相关性。Rho/Rho相关卷曲螺旋形成蛋白激酶(Rho/Rho associ-ated coiledcoil forming protein kinase, Rho/RO... 在神经网络中,神经可塑性是大脑响应内在和外在刺激的重要特征。越来越多的研究已经阐明了神经可塑性与神经损伤性疾病之间的相关性。Rho/Rho相关卷曲螺旋形成蛋白激酶(Rho/Rho associ-ated coiledcoil forming protein kinase, Rho/ROCK)通路是生物体广泛存在的经典信号通路,参与细胞迁移、树突发育和轴突延伸,并且与帕金森、精神发育迟滞和阿尔茨海默症等多种神经退行性或损伤性疾病有关。本文对Rho/ROCK信号通路与神经可塑性的研究进展予以综述,讨论了ROCK抑制剂对各种神经疾病的潜在治疗前景。 展开更多
关键词 RHO ROCK 神经可塑性 ROCK抑制剂
Computational methods for fracture in rock:a review and recent advances
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作者 Ali JENABIDEHKORDI 《结构与土木工程前沿:英文版》 EI CSCD 2019年第2期273-287,共15页
We present an overview of the most popular state-of-the-art computational methods available for modelling fracture in rock. The summarized numerical methods can be classified into three categories: Continuum Based Met... We present an overview of the most popular state-of-the-art computational methods available for modelling fracture in rock. The summarized numerical methods can be classified into three categories: Continuum Based Methods, Discrete Crack Approaches, and Block-Based Methods. We will not only provide an extensive review of those methods which can be found elsewhere but particularly address their potential in modelling fracture in rock mechanics and geotechnical engineering. In this context, we will discuss their key applications, assumptions, and limitations. Furthermore, we also address 'general' difficulties that may arise for simulating fracture in rock and fractured rock. This review will conclude with some final remarks and fiiture challenges. 展开更多
关键词 NUMERICAL MODELLING method development ROCK MECHANICS fractured ROCK ROCK FRACTURING
银杏叶提取物对脑缺血再灌注损伤大鼠血脑屏障的保护作用及ROCK、MLCK、MMP-2表达的影响
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作者 徐悦 邓超 郑永强 《四川中医》 2019年第7期44-48,共5页
目的:探讨银杏叶提取物对脑缺血再灌注损伤大鼠血脑屏障的保护作用及对大脑组织中相关卷曲螺旋形成蛋白激酶(ROCK)、肌球蛋白轻链激酶(MLCK)、金属基质蛋白酶2(MMP-2)表达的影。方法:将大鼠分为假手术组、模型组、银杏叶低、中、高剂量... 目的:探讨银杏叶提取物对脑缺血再灌注损伤大鼠血脑屏障的保护作用及对大脑组织中相关卷曲螺旋形成蛋白激酶(ROCK)、肌球蛋白轻链激酶(MLCK)、金属基质蛋白酶2(MMP-2)表达的影。方法:将大鼠分为假手术组、模型组、银杏叶低、中、高剂量组,采用线栓法制备动物大脑中动脉栓塞模型,缺血2小时后拔出线栓实现续流再灌注。银杏叶低、中、高剂量组在缺血后2小时分别腹腔注射给予50、100、200mg/kg的银杏叶提取物,持续给予3天,假手术组和模型组给予等量生理盐水。在于缺血2小时后和造模后96小时进行神经运动功能评分后处死大鼠,分离脑组织进行梗死体积测量、检测血脑屏障通透性检测和脑组织中ROCK、MLCK、MMP-2表达检测。结果:模型组神经运动功能评分、ROCK、MLCK、MMP-2蛋白表达水平较假手术组增加,差异有统计学意义(P<0.05);银杏能显著降低神经运动功能评分、梗死体积、EB渗漏、ROCK、MLCK和MMP-2蛋白表达水平,且具有一定的剂量关系,差异有统计学意义(P<0.05)。结论:银杏叶提取物能下调ROCK、MLCK、MMP-2水平,减小脑梗死体积,减轻血脑屏障损伤,发挥神经保护作用。 展开更多
关键词 银杏叶提取物 脑缺血再灌注 血脑屏障 ROCK MLCK MMP-2
Rho/ROCK信号通路在牙周膜细胞中作用的研究进展 预览
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作者 张研 张源 +2 位作者 石雪 贾彦 辛琪 《继续医学教育》 2019年第3期121-123,共3页
Rho/Rho相关的盘绕蛋白激酶(ROCK)信号是细胞骨架动力学的重要调节因子之一,它主动地和(或)被动地决定着细胞的命运,如增殖、迁移、分化和凋亡。在牙周创面愈合过程中,重要的是在缺损部位吸收新生干细胞,以促进牙周组织的再生和稳态。... Rho/Rho相关的盘绕蛋白激酶(ROCK)信号是细胞骨架动力学的重要调节因子之一,它主动地和(或)被动地决定着细胞的命运,如增殖、迁移、分化和凋亡。在牙周创面愈合过程中,重要的是在缺损部位吸收新生干细胞,以促进牙周组织的再生和稳态。牙周膜(PDL)细胞含有异质性成纤维细胞,包括间充质干细胞,有助于牙齿支持组织的重建。因此,PDL细胞的生物再生一直是牙周治疗的最终目标。文章介绍了Rho/ROCK信号对牙周膜细胞的影响的最新认识。 展开更多
关键词 RHO ROCK 牙周膜
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考虑岩体完整程度影响的爆破破裂范围 预览
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作者 谢福君 张家生 陈俊桦 《中南大学学报:自然科学版》 EI CAS CSCD 北大核心 2019年第6期1403-1410,共8页
根据岩石爆破损伤理论,在现场开展单孔爆破试验和钻孔超声波波速试验。通过钻孔超声波波速试验测量爆破前后岩体中纵波波速的变化,并根据与岩体完整程度相关的爆破破裂判据得到不同完整程度的岩体爆破破裂范围。由于该判据与爆破前岩体... 根据岩石爆破损伤理论,在现场开展单孔爆破试验和钻孔超声波波速试验。通过钻孔超声波波速试验测量爆破前后岩体中纵波波速的变化,并根据与岩体完整程度相关的爆破破裂判据得到不同完整程度的岩体爆破破裂范围。由于该判据与爆破前岩体完整性系数、爆破前后岩体纵波波速等参数相关,因此,根据试验结果可以定量分析岩体爆破破裂范围随岩体完整性系数的变化规律,从而定量分析考虑岩体完整程度对爆破破裂范围的影响。研究结果表明:岩体爆破破裂范围与岩体完整性系数之间的相关性良好;当爆破参数相同时,随着岩体完整性系数减小,最大爆破破裂半径和孔底最大破裂深度这2个爆破破裂范围参数均显著增大;所给出的爆破破裂判据和岩体爆破破裂评价方法简单、实用,可用于考虑岩体完整程度影响的围岩爆破安全稳定性评价。 展开更多
关键词 岩石 爆破 损伤力学 岩体完整性系数 纵波波速
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Distribution and gas-bearing properties of Permian igneous rocks in Sichuan Basin, SW China 预览
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作者 MA Xinhua LI Guohui +5 位作者 YING Danlin ZHAGN Benjian LI Ya DAI Xin FAN Yi ZENG Yunxian 《石油勘探与开发:英文版》 2019年第2期228-237,共10页
Based on the analysis of outcrop, seismic, logging and drilling data, combined with exploration practice, the characteristics,distribution, reservoir performance and gas-bearing properties of Permian igneous rocks in ... Based on the analysis of outcrop, seismic, logging and drilling data, combined with exploration practice, the characteristics,distribution, reservoir performance and gas-bearing properties of Permian igneous rocks in Sichuan Basin are studied. The study shows that central volcanic eruptive facies are developed in Sichuan Basin, and their lithological assemblages and distribution characteristics show obvious differences. The igneous rocks are mainly distributed in three regions: the southwestern part of the basin has dominantly largescale overflow facies basalts;the central and western part of the basin, Jianyang-Santai area, develop intrusive rocks, volcanic lavas(basalts)and pyroclastic rocks;and the eastern part of Sichuan, Dazhou-Liangping area, only develop diabase and basalts. Five aspects of understandings are achieved:(1) The Upper Permian igneous rocks can be divided into intrusive rocks and extrusive rocks, with the extrusive rocks as the main body. The chemical compositions of the extrusive rocks are characterized by both alkaline basalt and tholeiitic basalt, and belong to the subalkaline type of transitional basalt magma eruption.(2) There are obvious rhythmic structures vertically among overflow facies basalt, and the single rhythmic layer consists of, from bottom up, pyroclastic rocks(undeveloped), gray and dark gray porphyritic basalts(unstable), dark gray and purple microcrystalline-cryptocrystalline basalts, dark greyish green porous and amygdaloid basalts;the central volcanic eruption shows the rhythm and the vertical sequence of volcanic clastic rocks(agglomerates and breccias), volcanic lava, tuffaceous lava from bottom to top.(3) The pore types of basalt and pyroclastic rocks are diverse, mainly dissolution pore and de-vitrification micropore, but their physical properties are different. Basalt is characterized by ultra-low pore permeability, small reservoir thickness, and reservoirs are distributed in the upper and middle parts of the cycle, with poor lateral comparability. Volcanic clastic 展开更多
关键词 Sichuan Basin Upper PERMIAN Maokou Formation IGNEOUS ROCK volcanic lava PYROCLASTIC ROCK RESERVOIR property GAS bearing natural GAS RESERVOIR
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The HoekeBrown failure criterion and GSI-2018 edition 预览
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作者 E.Hoek E.T.Brown 《岩石力学与岩土工程学报:英文版》 CSCD 2019年第3期445-463,共19页
The HoekeBrown criterion was introduced in 1980 to provide input for the design of underground excavations in rock.The criterion now incorporates both intact rock and discontinuities,such as joints,characterized by th... The HoekeBrown criterion was introduced in 1980 to provide input for the design of underground excavations in rock.The criterion now incorporates both intact rock and discontinuities,such as joints,characterized by the geological strength index(GSI),into a system designed to estimate the mechanical behaviour of typical rock masses encountered in tunnels,slopes and foundations.The strength and deformation properties of intact rock,derived from laboratory tests,are reduced based on the properties of discontinuities in the rock mass.The nonlinear HoekeBrown criterion for rock masses is widely accepted and has been applied in many projects around the world.While,in general,it has been found to provide satisfactory estimates,there are several questions on the limits of its applicability and on the inaccuracies related to the quality of the input data.This paper introduces relatively few fundamental changes,but it does discuss many of the issues of utilization and presents case histories to demonstrate practical applications of the criterion and the GSI system. 展开更多
关键词 HOEK-BROWN criterion Geological STRENGTH index(GSI) ROCK MASS STRENGTH Uniaxial compressive strength(UCS) Tension cut-off ROCK MASS deformation modulus
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Strength of massive to moderately jointed hard rock masses 预览
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作者 R.P.Bewick P.K.Kaiser F.Amann 《岩石力学与岩土工程学报:英文版》 CSCD 2019年第3期562-575,共14页
The Hoek-Brown (HB) failure criterion and the geological strength index (GSI) were developed for the estimation of rock mass strength in jointed and blocky ground where rock mass failure is dominated by sliding along ... The Hoek-Brown (HB) failure criterion and the geological strength index (GSI) were developed for the estimation of rock mass strength in jointed and blocky ground where rock mass failure is dominated by sliding along open joints and rotation of rock blocks. In massive, veined and moderately jointed rock in which rock blocks cannot form without failure of intact rock, the approach to obtain HB parameters must be modified. Typical situations when these modifications are required include the design of pillars, excavation and cavern stability, strainburst potential assessment, and tunnel support in deep underground conditions (around σ1/σci > 0.15, where σ1 is the major principal compressive stress and σci is the unconfined compressive strength of the homogeneous rock) in hard brittle rocks with GSI ≥ 65. In this article, the strength of massive to moderately jointed hard rock masses is investigated, and an approach is presented to estimate the rock mass strength envelope using laboratory data from uniaxial and triaxial compressive strength tests without reliance on the HB-GSI equations. The data from tests on specimens obtained from massive to moderately jointed heterogeneous (veined) rock masses are used to obtain the rock and rock mass strengths at confining stress ranges that are relevant for deep tunnelling and mining;and a methodology is presented for this purpose from laboratory data alone. By directly obtaining the equivalent HB rock mass strength envelope for massive to moderately jointed rock from laboratory tests, the HB-GSI rock mass strength estimation approach is complemented for conditions where the GSIequations are not applicable. Guidance is also provided on how to apply the proposed approach when laboratory test data are not or not yet available. 展开更多
关键词 BRITTLE ROCK Uniaxial compressive strength(UCS) Geological STRENGTH index(GSI) MASSIVE to moderately jointed ROCK MASSES
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A method to determine relevant geomechanical parameters for evaluating the hydraulic erodibility of rock 预览
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作者 Lamine Boumaiza Ali Saeidi Marco Quirion 《岩石力学与岩土工程学报:英文版》 CSCD 2019年第5期1004-1018,共15页
Among the methods used for evaluating the potential hydraulic erodibility of rock,the most common methods are those based on the correlation between the force of flowing water and the capacity of a rock to resist eros... Among the methods used for evaluating the potential hydraulic erodibility of rock,the most common methods are those based on the correlation between the force of flowing water and the capacity of a rock to resist erosion,such as Annandale’s and Pells’methods.The capacity of a rock to resist erosion is evaluated based on erodibility indices that are determined from specific geomechanical parameters of a rock mass.These indices include unconfined compressive strength(UCS)of rock,rock block size,joint shear strength,a block’s shape and orientation relative to the direction of flow,joint openings,and the nature of the surface to be potentially eroded.However,it is difficult to determine the relevant geomechanical parameters for evaluating the hydraulic erodibility of rock.The assessment of eroded unlined spillways of dams has shown that the capacity of a rock to resist erosion is not accurately evaluated.Using more than 100 case studies,we develop a method to determine the relevant geomechanical parameters for evaluating the hydraulic erodibility of rock in unlined spillways.The UCS of rock is found not to be a relevant parameter for evaluating the hydraulic erodibility of rock.On the other hand,we find that the use of three-dimensional(3D)block volume measurements,instead of the block size factor used in Annandale’s method,improves the rock block size estimation.Furthermore,the parameter representing the effect of a rock block’s shape and orientation relative to the direction of flow,as considered in Pells’method,is more accurate than the parameter adopted by Annandale’s method. 展开更多
关键词 ROCK mass HYDRAULIC ERODIBILITY Geomechanical parameters ROCK block size Annandale’s METHOD Pells’method Kirsten’s index EROSION level
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Rock burst risk evaluation based on equivalent surrounding rock strength 预览
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作者 Jinglin Wen Husheng Li +3 位作者 Fuxing Jiang Zhengxing Yu Haitao Ma Xiaolin Yang 《矿业科学技术学报:英文版》 CSCD 2019年第4期571-576,共6页
On-site investigations consistently show that the rock burst inherent to coal seams varies greatly with coal seam thickness.In this study,impact factors related to coal seam thickness and surrounding rock strength wer... On-site investigations consistently show that the rock burst inherent to coal seams varies greatly with coal seam thickness.In this study,impact factors related to coal seam thickness and surrounding rock strength were analyzed and a corresponding rock burst risk assessment method was constructed.The model reflects the influence of coal seam thickness on the stress distribution of surrounding rock at the roadway.Based on the roadway excavation range,a stress distribution model of surrounding roadway rock is established and the influence of coal seam thickness on rock burst risk is analyzed accordingly.The proposed rock burst risk assessment method is based on the equivalent surrounding rock strength and coal seam bursting liability.The proposed method was tested in a 3500 mining area to find that it yields rock burst risk assessment results as per coal seam thickness that are in accordance with real-world conditions.The results presented here suggest that coal seam thickness is a crucial factor in effective rock burst risk assessment. 展开更多
关键词 Mining engineering Coal seam thickness Rock burst risk Equivalent surrounding rock strength Bursting liability
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Research progreess on relevant diseases of RhoA/ROCK signaling pathway
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作者 Jian-Bing Liu Min-Li Liu 《海南医科大学学报(英文版)》 2019年第6期73-76,共4页
RhoA (Ras homolog gene family member A) belongs to the Rho subfamily of GTPases. ROCK (Rho—associated coiled—coil forming protein kinase) is downstream of the active RhoA and affects the generation and secretion of ... RhoA (Ras homolog gene family member A) belongs to the Rho subfamily of GTPases. ROCK (Rho—associated coiled—coil forming protein kinase) is downstream of the active RhoA and affects the generation and secretion of cellular element, which will result in relevant biologic effects. The RhoA/ROCK signaling pathway consists of these serious reactions. Therefore, the activation and inhibition of this pathway are closely related to the occurrence and development of many diseases. The research on the molecular mechanism of these diseases may be instructive and helpful to the clinical treatmen and prognosis of diseases. Recent studies of these typical diseases related to RhoA/ROCK signaling pathway are viewed in this article. 展开更多
关键词 RHOA ROCK RhoA/ROCK Signaling pathway PHOSPHORYLATION
不同岩性下TBM滚刀破岩过程离散元分析 预览
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作者 杨开新 蒋明镜 +1 位作者 陈有亮 廖优斌 《水资源与水工程学报》 CSCD 2019年第2期198-204,211共8页
为了研究全断面岩石掘进机(TBM)的滚刀在不同岩性下的破岩机理,将考虑胶结尺寸的微观接触模型植入离散元软件,模拟了4种岩性下不同滚刀刃数的破岩过程,探究岩性、滚刀刃数对破岩效率的影响。模拟结果表明:不同滚刀刃数下的破岩过程可以... 为了研究全断面岩石掘进机(TBM)的滚刀在不同岩性下的破岩机理,将考虑胶结尺寸的微观接触模型植入离散元软件,模拟了4种岩性下不同滚刀刃数的破岩过程,探究岩性、滚刀刃数对破岩效率的影响。模拟结果表明:不同滚刀刃数下的破岩过程可以分为3个阶段,即加载阶段、卸载阶段及残余跃进阶段;胶结破坏类型主要呈拉剪破坏与压剪破坏两种;滚刀破岩过程中受到的阻力可以用峰值法向推力表示,阻力大小取决于岩性,破岩阻力随着岩石单轴抗压强度的增大而增大;通过胶结破岩比能耗来评价破岩效率,对于坚硬岩,三滚刀破岩效率最高,对于强度较低的岩石,采用单滚刀破岩效率更高。 展开更多
关键词 岩石 岩石掘进机(TBM) 岩性 滚刀刃数 破岩效率 离散单元法
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Attenuation of rock blasting induced ground vibration in rock-soil interface 预览
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作者 Bhagya Jayasinghe Zhiye Zhao +2 位作者 Anthony Goh Teck Chee Hongyuan Zhou Yilin Gui 《岩石力学与岩土工程学报:英文版》 CSCD 2019年第4期770-778,共9页
Blasting has been widely used in mining and construction industries for rock breaking.This paper presents the results of a series of field tests conducted to investigate the ground wave propagation through mixed geolo... Blasting has been widely used in mining and construction industries for rock breaking.This paper presents the results of a series of field tests conducted to investigate the ground wave propagation through mixed geological media.The tests were conducted at a site in the northwestern part of Singapore composed of residual soil and granitic rock.The field test aims to provide measurement data to better understand the stress wave propagation in soil/rock and along their interface.Triaxial accelerometers were used for the free field vibration monitoring.The measured results are presented and discussed,and empirical formulae for predicting peak particle velocity (PPV) attenuation along the ground surface and in soil/rock were derived from the measured data.Also,the ground vibration attenuation across the soil-rock interface was carefully examined,and it was found that the PPV of ground vibration was decreased by 37.2% when it travels from rock to soil in the vertical direction. 展开更多
关键词 Rock BLASTING Field tests BLAST wave propagation PEAK particle velocity (PPV) Rock-soil INTERFACE
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Determining relative block structure rating for rock erodibility evaluation in the case of non-orthogonal joint sets 预览
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作者 Lamine Boumaiza Ali Saeidi Marco Quirion 《岩石力学与岩土工程学报:英文版》 CSCD 2019年第1期72-87,共16页
The most commonly used method for assessing the hydraulic erodibility of rock is Annandale’s method.This method is based on a correlation between the erosive force of flowing water and the capacity of rock resistance... The most commonly used method for assessing the hydraulic erodibility of rock is Annandale’s method.This method is based on a correlation between the erosive force of flowing water and the capacity of rock resistance.This capacity is evaluated using Kirsten’s index,which was initially developed to evaluate the excavatability of earth materials.For rocky material,this index is determined according to certain geomechanical factors related to intact rock and rock mass,such as compressive strength of intact rock,rock block size,discontinuity shear strength and relative block structure.To quantify the relative block structure,Kirsten(1982)developed a mathematical expression that accounts for the shape and orientation of the blocks relative to the direction of flow.Kirsten’s initial concept for assessing the relative block structure considers that the geological formation is mainly fractured by two joint sets forming an orthogonally fractured system.An adjusted concept is proposed to determine the relative block structure when the fractured system is non-orthogonal where the angle between the planes of the two joint sets is greater or less than 90.An analysis of the proposed relative block structure rating shows that considering a non-orthogonally fractured system has a significant effect on Kirsten’s index and,as a consequence,on the assessment of the hydraulic erodibility of rock. 展开更多
关键词 Fractured ROCK DIP angle DIP direction JOINT SPACING RELATIVE block structure Hydraulic ERODIBILITY of ROCK Annandale’s method Kirsten’s index
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脊髓损伤中RhoA/ROCK通路的作用机制研究
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作者 王勃霏 姜晓玲 +3 位作者 卢斌 赵红卫 蔡惠丽 陈海丹 《生命的化学》 CAS CSCD 2019年第3期588-593,共6页
脊髓损伤是一种严重的中枢神经系统损伤,常导致患者瘫痪或死亡,预后差。脊髓损伤主要包括机械损伤和继发性损伤两个过程。在继发性损伤过程中,多种信号通路被激活,在脊髓损伤的发病机制中起重要作用,其中,RhoA/Rho信号通路在脊髓变性和... 脊髓损伤是一种严重的中枢神经系统损伤,常导致患者瘫痪或死亡,预后差。脊髓损伤主要包括机械损伤和继发性损伤两个过程。在继发性损伤过程中,多种信号通路被激活,在脊髓损伤的发病机制中起重要作用,其中,RhoA/Rho信号通路在脊髓变性和再生中起着特殊的作用。本文讨论RhoA/Rho激酶信号介导的脊髓发病机制,以及针对RhoA/ROCK通路靶向药物的治疗进展。 展开更多
关键词 脊髓损伤 RHOA ROCK
Characteristics of parametamorphic rock reservoirs in Pingxi area, Qaidam Basin, NW China 预览
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作者 XIA Zhiyuan LIU Zhanguo +5 位作者 LI Senming ZHANG Yongshu WANG Bo TIAN Mingzhi WU Jin ZOU Kaizhen 《石油勘探与开发:英文版》 2019年第1期93-103,共11页
Based on core, thin-section, scanning electron microscopy(SEM) and well logging data, the characteristics of the parametamorphic rock reservoirs in the Pingxi area were analyzed by means of whole rock X-ray diffractio... Based on core, thin-section, scanning electron microscopy(SEM) and well logging data, the characteristics of the parametamorphic rock reservoirs in the Pingxi area were analyzed by means of whole rock X-ray diffraction and micron CT scanning. The parametamorphic rock reservoirs mainly had three types of rocks: slate, crystalline limestone and calc-schist;the original rocks were Ordovician-Silurian marine clastic and carbonate rocks. The three types of parametamorphic rock reservoirs developed three types and six sub-types of reservoir space. The first type of reservoir space was fractures, including structural, weathered and dissolution fractures;the second type was dissolved porosities, including dissolved pores and caves;the third type was nano-sized intercrystalline porosities. The three types of parametamorphic rock reservoirs were different widely in the quantity, volume and radius of pore-throats, and were strongly affected by the type and development degree of fractures. The parametamorphic rock reservoirs were formed by metamorphism, weathering, structural fragmentation and dissolution. Metamorphism reformed the parametamorphic rock reservoirs significantly, breaking the traditional constraint of finding weathering crust at top. The parametamorphic rock reservoirs experienced five formation stages, and their distribution was controlled by rock type, metamorphic degree, ancient geomorphology, and weathering intensity. 展开更多
关键词 Qaidam Basin Pingxi area parametamorphic ROCK RESERVOIR ROCK type pore THROAT CHARACTERISTICS RESERVOIR formation RESERVOIR distribution
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西南喀斯特流域枯季地下水电导率特征及水-岩作用分析
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作者 朱彪 陈喜 +4 位作者 张志才 彭韬 张乐辰 陈波 赵美刚 《地球与环境》 CAS CSCD 北大核心 2019年第4期459-463,共5页
受特殊水文地质条件影响,西南喀斯特流域水动力过程与物质循环过程复杂,利用单一水文信息分析该地区水动力过程具有较大难度.地下水电导率受喀斯特水文地质条件影响显著,可以综合反映区域水动力条件与岩性特征.论文选取贵州普定县后寨... 受特殊水文地质条件影响,西南喀斯特流域水动力过程与物质循环过程复杂,利用单一水文信息分析该地区水动力过程具有较大难度.地下水电导率受喀斯特水文地质条件影响显著,可以综合反映区域水动力条件与岩性特征.论文选取贵州普定县后寨河流域为研究区,通过野外调查及地下水电导率原位测定,结合流域地形、岩性及落水洞、岩溶泉等岩溶地貌空间分布规律,分析了喀斯特流域枯季地下水电导率空间分布及其受水-岩特征的影响.结果表明,山丘区地下水电导率较低,主要由于喀斯特山区是岩溶裂隙/管道网络发育的强径流区,水-岩接触时间较短.随高程降低,地下水电导率呈现增加趋势,表明地下水流速度减缓,水-岩接触时间变长.地下水电导率受岩性特征影响显著,石灰岩区水-岩作用强烈,易形成较高电导率地下水,平均电导率650μS/cm,白云岩区水-岩作用减弱,地下水电导率降低,平均值523μS/cm. 展开更多
关键词 喀斯特流域 电导率 水动力条件 岩性 枯季
冲击荷载作用下岩石压动态和拉动态损伤模型 预览
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作者 谢福君 张家生 陈俊桦 《中南大学学报:自然科学版》 EI CAS CSCD 北大核心 2019年第2期420-427,共8页
根据经典岩石冲击动态损伤模型和统计损伤力学理论,提出冲击荷载加载条件下的岩石压、拉统计损伤本构模型和冲击损伤判据模型。在该损伤模型中,将损伤演化关系分为体积压缩损伤和体积拉伸损伤2种。应用提出的损伤模型和经典动态拉伸损... 根据经典岩石冲击动态损伤模型和统计损伤力学理论,提出冲击荷载加载条件下的岩石压、拉统计损伤本构模型和冲击损伤判据模型。在该损伤模型中,将损伤演化关系分为体积压缩损伤和体积拉伸损伤2种。应用提出的损伤模型和经典动态拉伸损伤模型分别进行爆破损伤数值模拟,并将数值计算结果和现场实测结果进行对比。研究结果表明:与炮孔轴向相比,炮孔径向是爆破破裂延伸的主方向;沿炮孔径向主要发生拉伸破裂,孔底下方主要发生压缩破裂;与基于经典冲击动态拉伸损伤模型的数值计算结果相比,根据损伤模型得到的爆破破裂范围特别是孔底正下方破裂深度与实测值相差不大且最接近实测值,表明所提出的损伤模型是合理的,具有实用性。 展开更多
关键词 岩石 动力损伤作用 压缩 拉伸 爆破数值模拟
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Numerical simulation and experimental study on dissolving characteristics of layered salt rocks
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作者 Qiqi Wanyan Yiming Xiao Na Tang 《中国化学工程学报:英文版》 SCIE EI CAS CSCD 2019年第5期1030-1036,共7页
Underground salt cavern reservoirs are ideal spaces for energy storage. China is rich in salt rock resources with layered lacustrine sedimentary structures. However, the dissolution mechanism of layered salt rocks rem... Underground salt cavern reservoirs are ideal spaces for energy storage. China is rich in salt rock resources with layered lacustrine sedimentary structures. However, the dissolution mechanism of layered salt rocks remains poorly understood, resulting in significant differences between the actual measurements and the designed indices for the layered salt rock water-soluble cavity-making cycle and the cavity shape. In this work, the dissolution rates of 600 groups of layered salt rocks in China under different conditions were determined experimentally.Thus, the established artificial neural network prediction model was used to assess the effects of the contents of NaCl, Na2 SO4, and CaSO4 in the salt rocks, concentrations, dissolution angles, and flow rates on their dissolution rates by performing ANOVA and F-test. The results provide a theoretical basis for evaluating the dissolution rate of layered salt rocks under different conditions and for the numerical simulation of the layered salt rock water-soluble cavity-making process. 展开更多
关键词 SALT CAVERN RESERVOIRS LAYERED SALT rock DISSOLUTION rate ANOVA
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