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Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors 预览
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作者 Orsolya Galamb Barbara K Barták +5 位作者 Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第34期5026-5048,共23页
Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and ... Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. 展开更多
关键词 Long NON-CODING RNA COLORECTAL cancer COLORECTAL adenoma CIRCULATING long NON-CODING RNAs Exosome Biomarker DIAGNOSTIC MARKER PROGNOSTIC MARKER
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In the Peach Carden 预览
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作者 薛茹霞 《阅读》 2019年第7期44-49,共6页
Long long ago,there was the Peach Garden.People were very happy there.One day,a fisherman found it.Then,what happened?你听过《桃花源》的故事吗?快来看看江苏省无锡市阳山中心小学同学们的精彩演绎吧!
关键词 LONG LONG PEACH GARDEN 《桃花源》
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LSTM Based Reserve Prediction for Bank Outlets
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作者 Yu Liu Shuting Dong +1 位作者 Mingming Lu Jianxin Wang 《清华大学学报自然科学版(英文版)》 EI CAS CSCD 2019年第1期77-85,共9页
Reserve allocation is a significant problem faced by commercial banking businesses every day.To satisfy the cash requirement of customers and abate the vault cash pressure,commercial banks need to appropriately alloca... Reserve allocation is a significant problem faced by commercial banking businesses every day.To satisfy the cash requirement of customers and abate the vault cash pressure,commercial banks need to appropriately allocate reserves for each bank outlet.Excessive reserve would impact the revenue of bank outlets.Low reserves cannot guarantee the successful operation of bank outlets.Considering the reserve requirement is effected by the past cash balance,we deal the reserve allocation problem as a time series prediction problem,and the Long Short Time Memory (LSTM)network is adapted to solve it.In addition,the proposed LSTM prediction model regards date property,which can affect the cash balance,as a primary factor.The experiment results show that our method outperforms some existing traditional methods. 展开更多
关键词 RESERVE PREDICTION TIME series PREDICTION LONG SHORT TIME Memory (LSTM)network DATE property
Evolution of interfacial dislocation networks during long term thermal aging in Ni-based single crystal superalloy DD5
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作者 Qiang Gao Li-rong Liu +3 位作者 Xiao-hua Tang Zhi-jiang Peng Ming-jun Zhang Su-gui Tian 《中国铸造:英文版》 SCIE 2019年第1期14-22,共9页
Interfacial dislocations found in single crystal superalloys after long term thermal aging have an important effect on mechanical properties. Long term thermal aging tests for DD5 single crystal superalloy were carrie... Interfacial dislocations found in single crystal superalloys after long term thermal aging have an important effect on mechanical properties. Long term thermal aging tests for DD5 single crystal superalloy were carried out at 1,100 ℃ for 20, 100, 200, 500 and 1000 h, and then cooled by air. The effect of long term thermal aging on the dislocation networks at the γ/γ’ interfaces was investigated by FE-SEM. Results showed that during the long term thermal aging at 1,100 ℃, misfit dislocations formed firstly and then reorientation in the(001) interfacial planes occurred. Different types of square or rectangular dislocation network form by dislocation reaction. Square dislocation networks consisting of four groups of dislocations can transform into octagonal dislocation networks, and then form another square dislocation network by dislocation reaction. Rectangular dislocation networks can also transform into hexagonal dislocation networks. The interfacial dislocation networks promote the γ’ phase rafting process. The dislocation networks spacings become smaller and smaller, leading to the effective lattice misfit increasing from-0.10% to-0.32%. 展开更多
关键词 DD5 single crystal SUPERALLOY INTERFACIAL dislocations long TERM thermal AGING effective LATTICE MISFIT
Integrating transcriptomic and proteomic analyses of photoperiodsensitive in near isogenic maize line under long-day conditions 预览
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作者 SONG Xiao-heng TIAN Lei +6 位作者 WANG Shun-xi ZHOU Jin-long ZHANG Jun CHEN Zan WU Liu-ji KU Li-xia CHEN Yan-hui 《农业科学学报:英文版》 SCIE CAS CSCD 2019年第6期1211-1221,共11页
As a short-day plant species, maize requires an optimal photoperiod for inducing reproductive growth. However, there is a lack of information regarding photoperiod-induced changes in maize mRNA and protein levels. In ... As a short-day plant species, maize requires an optimal photoperiod for inducing reproductive growth. However, there is a lack of information regarding photoperiod-induced changes in maize mRNA and protein levels. In this study, a photoperiod-insensitive maize inbred line and its near isogenic photoperiod-sensitive line were used. By integrating RNAbased transcriptomic and iTRAQ LC-MS/MS-based proteomic approaches, we generated a comprehensive inventory of the transcripts and proteins with altered abundances in response to a long photoperiod(LP) during growth stage transitions. We detected 22 000 transcripts in RNA-sequence runs and 5 259 proteins from an iTRAQ-based analysis. A weak correlation between mRNA-and protein-level changes was observed, suggesting the LP-induced transition between maize growth stages is largely regulated post-transcriptionally. Differentially expressed genes influenced by LP conditions were associated with several regulatory processes in both maize inbred lines, especially phosphate ion transport and the circadian rhythm. Additionally, 31 transcripts and six proteins related to photoperiodic flowering in maize were identified by comparing transcriptomic and proteomic data. This transcriptomic and proteomic analysis represents the first comprehensive and comparative study of gene/protein-level changes occurring in photoperiod-sensitive and-insensitive maize inbred lines during growth stage transitions under LP conditions. 展开更多
关键词 development transition long PHOTOPERIOD NEAR isogenic LINE PROTEOME transcriptome
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Achievement of 1000 s plasma generation of RF source for neutral beam injector
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作者 胡纯栋 谢亚红 +7 位作者 许永建 蒋才超 韦江龙 顾玉明 崔庆龙 梁立振 陈世勇 谢远来 《等离子体科学与技术:英文版》 SCIE EI CAS CSCD 2019年第2期5-8,共4页
A radio frequency(RF) ion source was developed for neutral beam injector in Institute of Plasma Physics, Chinese Academy of Sciences(ASIPP). A cylindrical driver based RF plasma source was tested and optimized for lon... A radio frequency(RF) ion source was developed for neutral beam injector in Institute of Plasma Physics, Chinese Academy of Sciences(ASIPP). A cylindrical driver based RF plasma source was tested and optimized for long pulse operation. Recently, the plasma source achieved 1000 s stable plasma discharge with RF power of 35 k W and source pressure of 0.7 Pa for the first time.The heat loading on each of driver components such as the Faraday shield(FS), RF coil and expansion chamber was measured by the water flow calorimeter system. The experiment results showed that FS is the component with highest heat loading and the heat loading on FS was about 65.8% of total heat loading on source. The details of the long pulse operation of RF plasma source are presented in this paper. 展开更多
关键词 NEUTRAL BEAM INJECTOR RF ion source water flow CALORIMETER long PULSE
Efficient Grinding Method for Face Gear with Long Radius Disk Wheel 预览
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作者 Yanzhong Wang Xiaomeng Chu +3 位作者 Guoying Su Weiqiang Zhao Yueming He Long Wu 《北京理工大学学报:英文版》 EI CAS 2019年第3期635-643,共9页
In order to improve the machining efficiency of the dish wheel grinding face gear, two changes are proposed:a disk wheel grinding face gear with a long radius and a multi-axis movement optimization method for tooth su... In order to improve the machining efficiency of the dish wheel grinding face gear, two changes are proposed:a disk wheel grinding face gear with a long radius and a multi-axis movement optimization method for tooth surface correction. Based on the grinding principle of face gears, the equation of the long radius disk wheel is deduced. Based on the structure of the machining tool, the tooth surface equations of the face gear shaped by the long radius disk wheel are established. Furthermore, an optimization model of face gear tooth surface correction is established, and the machine tool motion optimization of face gear tooth surface correction is completed;Finally, a long radius disk wheel grinding face gear test is performed. After the face gear tooth surface correction, the maximum value of the tooth surface deviation is reduced from 180 μm to 16 μm which verified the correctness of the machining method. 展开更多
关键词 LONG RADIUS DISK WHEEL face gear TOOTH surface correction EFFICIENT grinding
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Unsupervised Electric Motor Fault Detection by Using Deep Autoencoders 预览
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作者 Emanuele Principi Damiano Rossetti +1 位作者 Stefano Squartini Francesco Piazza 《自动化学报:英文版》 CSCD 2019年第2期441-451,共11页
Fault diagnosis of electric motors is a fundamental task for production line testing, and it is usually performed by experienced human operators. In the recent years, several methods have been proposed in the literatu... Fault diagnosis of electric motors is a fundamental task for production line testing, and it is usually performed by experienced human operators. In the recent years, several methods have been proposed in the literature for detecting faults automatically. Deep neural networks have been successfully employed for this task, but, up to the authors’ knowledge, they have never been used in an unsupervised scenario. This paper proposes an unsupervised method for diagnosing faults of electric motors by using a novelty detection approach based on deep autoencoders. In the proposed method, vibration signals are acquired by using accelerometers and processed to extract LogMel coefficients as features. Autoencoders are trained by using normal data only, i.e., data that do not contain faults. Three different autoencoders architectures have been evaluated: the multilayer perceptron(MLP) autoencoder, the convolutional neural network autoencoder, and the recurrent autoencoder composed of long short-term memory(LSTM) units. The experiments have been conducted by using a dataset created by the authors, and the proposed approaches have been compared to the one-class support vector machine(OC-SVM) algorithm. The performance has been evaluated in terms area under curve(AUC) of the receiver operating characteristic curve, and the results showed that all the autoencoder-based approaches outperform the OCSVM algorithm. Moreover, the MLP autoencoder is the most performing architecture, achieving an AUC equal to 99.11 %. 展开更多
关键词 Autoencoder convolutional NEURAL NETWORKS electric motor fault DETECTION long short-term memory NEURAL NETWORKS NOVELTY DETECTION
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Room-temperature continuous-wave operation of GaN-based blue-violet laser diodes with a lifetime longer than 1000h 预览
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作者 Feng Liang Jing Yang +9 位作者 Degang Zhao Zongshun Liu Jianjun Zhu Ping Chen Desheng Jiang Yongsheng Shi Hai Wang Lihong Duan Liqun Zhang Hui Yang 《半导体学报:英文版》 EI CAS CSCD 2019年第2期39-42,共4页
GaN-based continuous-wave operated blue-violet laser diodes(LDs) with long lifetime are demonstrated, which are grown on a c-plane GaN substrate by metal organic chemical vapor deposition with a 10 × 600 μm~2 ri... GaN-based continuous-wave operated blue-violet laser diodes(LDs) with long lifetime are demonstrated, which are grown on a c-plane GaN substrate by metal organic chemical vapor deposition with a 10 × 600 μm~2 ridge waveguide structure.The electrical and optical characteristics of a blue-violet LD are investigated under direct-current injection at room temperature(25 °C). The stimulated emission wavelength and peak optical power of the LD are around 413 nm and over 600 mW, respectively.In addition, the threshold current density and voltage are as small as 1.46 kA/cm~2 and 4.1 V, respectively. Moreover, the lifetime is longer than 1000 hours under room-temperature continuous-wave operation. 展开更多
关键词 GAN-BASED blue-violet laser DIODES long LIFETIME THRESHOLD voltage
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Development and Application of Coated Fertilizer in Japan 预览
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作者 Hiroshi Aoki Yuichi Sekiguti 《食品科学与工程:英文版(美国)》 2019年第4期142-152,共11页
The fertilizer industry faces a continuing challenge to improve its products to increase the fertilizer use efficiency and to minimize any possible adverse environmental impact.For this purpose,studies on the developm... The fertilizer industry faces a continuing challenge to improve its products to increase the fertilizer use efficiency and to minimize any possible adverse environmental impact.For this purpose,studies on the development of coated fertilizers have been done all over the world.In this paper,we are to introduce our coated urea“MEISTER”as the sophisticated fertilizer,with explaining the features and applications in actual fields.“MEISTER”is the coated urea with a mixture of polyolefin and silicate mineral.“MEISTER”has two releasing types.One is the linear type.Another is the sigmoidal type.Release of nitrogen from“MEISTER”mainly depends on temperature which allows precise prediction of nutrient release.Application experiments for rice,Chinese cabbage and long onion are introduced in this paper.Every experiment shows single basal application is possible by using“MEISTER”with keeping yield and high nitrogen recovery.Coated fertilizers show accurate release control of nutrients.The use of coated fertilizers brings:(a)efficient use of fertilizer resources,(b)reduction of environmental load by fertilizer,(c)labor saving.Thus applying coated fertilizers is definitely smart fertilization technology in agriculture.Coated fertilizers seem to closely meet the requirements of an ideal fertilizer.The problem is its high price compared to the normal rapid soluble fertilizer.Unit price of coated fertilizer is expensive on the surface,though total application cost of coated fertilizers is often cheaper than the cost of rapid soluble fertilizers.This sometime disturbs the spread of coated fertilizers.So,we have been trying to make an effort to reduce production cost and doing application enlargement trials of coated fertilizers for becoming more widespread.Through those studies and development,we believe coated fertilizers will contribute to agriculture more in the world. 展开更多
关键词 Coated FERTILIZER release control rice Chinese CABBAGE LONG ONION co-situs NITROGEN use efficiency
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Foam Forming: An Effective Method to Prepare Polyimide Fiber-based Paper 预览
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作者 Shunxi Song Xiaoli Zhen +2 位作者 Meiyun Zhang Peiyao Wang Jiaojun Tan 《造纸与生物质材料:英文版》 2019年第3期39-44,共6页
Well-dispersed fiber suspension is the precondition of good paper formation. Compared with cellulosic fibers, synthetic fibers are prone to flocculate because of their long length and hydrophobic nature, resulting in ... Well-dispersed fiber suspension is the precondition of good paper formation. Compared with cellulosic fibers, synthetic fibers are prone to flocculate because of their long length and hydrophobic nature, resulting in poor paper formation. To solve this problem, dispersants and extremely low forming consistency are typically adopted during the traditional wet-forming process, which cause a large amount of water consumption and treatment cost. Therefore, increasing forming consistency without compromising paper formation remains a challenge for papermakers. In this work, foam forming was adopted to disperse polyimide fibers (PI) with high forming consistency. The results showed that the formation index of handsheets increased when the bubble size and distribution became small and narrow. Compared with traditional wet-forming process with the same consistency (0.4%), the formation index of handsheets by foam forming increased by approximately 100% when C8 alkyl glucoside (APG08) concentration reached 16 g/L. Notably, forming consistency could increase by eight times while keeping the same level of paper formation. Overall, foam forming exhibits great advantages in dispersing long fiber and reducing water consumption and environmental pressure, and has potential applications in specialty paper made of long fibers. 展开更多
关键词 foam FORMING LONG PI fibers high FORMING CONSISTENCY BUBBLE size FORMATION
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Cell membrane-covered nanoparticles as biomaterials
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作者 Mingjun Xuan Jingxin Shao Junbai Li 《国家科学评论:英文版》 CSCD 2019年第3期551-561,共11页
Surface engineering of synthetic carriers is an essential and important strategy for drug delivery in vivo.However,exogenous properties make synthetic nanosystems invaders that easily trigger the passive immune cleara... Surface engineering of synthetic carriers is an essential and important strategy for drug delivery in vivo.However,exogenous properties make synthetic nanosystems invaders that easily trigger the passive immune clearance mechanism,increasing the retention effect caused by the reticuloendothelial systems and bioadhesion,finally leading to low therapeutic efficacy and toxic effects.Recently,a cell membrane cloaking technique has been reported as a novel interfacing approach from the biological/immunological perspective,and has proved useful for improving the performance of synthetic nanocarriers in vivo.After cell membrane cloaking,nanoparticles not only acquire the physiochemical properties of natural cell membranes but also inherit unique biological functions due to the presence of membrane-anchored proteins,antigens,and immunological moieties.The derived biological properties and functions,such as immunosuppressive capability,long circulation time,and targeted recognition integrated in synthetic nanosystems,have enhanced their potential in biomedicine in the future.Here,we review the cell membrane-covered nanosystems,highlight their novelty,introduce relevant biomedical applications,and describe the future prospects for the use of this novel biomimetic system constructed from a combination of cell membranes and synthetic nanomaterials. 展开更多
关键词 cell membranes SYNTHETIC nanosystem bio-stealth long CIRCULATION time BIOMEDICAL applications
Efficacy observation on long snake moxibustion for lumbar disc herniation with cold-dampness syndrome
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作者 胡秀武 邓陈英 +5 位作者 邱芬芬 唐丽梅 余希婧 耿乐乐 高洁 赵美玲 《世界针灸杂志:英文版》 CSCD 2019年第2期97-102,共6页
Objective:To observe and compare the clinical efficacy difference among long snake moxibustion,acupuncture and western medication for treating lumbar disc herniation with cold-dampness syndrome,and to provide a prefer... Objective:To observe and compare the clinical efficacy difference among long snake moxibustion,acupuncture and western medication for treating lumbar disc herniation with cold-dampness syndrome,and to provide a preferred treatment for cold-dampness lumbar disc herniation.Methods:A total of 90 patients with cold-dampness lumbar disc herniation were randomized into three groups according to the random number table,including the long snake moxibustion group(31 cases),the acupuncture group(28 cases)and the western medication group(31 cases).Treated with long snake moxibustion,patients in the long snake moxibustion group.The acupuncture group was treated with conventional acupuncture therapy,by adopting acupoints of Shènshū(肾俞 BL23),Dàchángshū(大肠俞BL25),Yāoyángguān(腰阳关GV3),Wěizhōng(委中 BL40)and local Ashi points.Patients in the western medication group were given oral diclofenac sodium.Visual analogous scale(VAS),Oswestry Dysfunction Index(ODI)score,yang deficiency scale score and clinical efficacy were observed before and after treatment.Results:(1)The VAS scores of the patients after treatment in each group decreased compared with those before the treatment.The long snake moxibustion group decreased from 7.22±1.14 to 1.10±0.75(P<0.05);the acupuncture group,from 6.75±1.18 to 1.46±0.88(P<0.05);and the western medication group,from 7.38±1.02 to 1.51 ±0.81(P<0.05).After treatment,the VAS score of the long snake moxibustion group was lower than that of the acupuncture and western medication groups,the differences were statistically significant(both P<0.05).(2)ODI scores of all the groups were lower than those before the treatment.The long snake moxibustion group decreased from 33.35±10.85 to 7.84±3.59(P<0.05);the acupuncture group,from 31.65±8.23 to 9.00±6.10(P<0.05);and the western medication group from 27.77±7.30 to 23.87±10.81(P<0.05).The score of ODI in the long snake moxibustion group was lower than those in the acupuncture and western medication groups,the differences were st 展开更多
关键词 Long SNAKE MOXIBUSTION LUMBAR DISC HERNIATION COLD-DAMPNESS
BANCR在甲状腺癌中的研究进展 预览
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作者 胡益 沈毅 +3 位作者 黎欢 姚旭 黄钧涛 吴淋蓉 《现代实用医学》 2019年第8期1130-1132,I0003共4页
长链非编码RNA(lncRNA)是一种不具有蛋白质编码能力的长链RNA,在基因表达的转录和转录后调控中发挥关键作用。新近发现的长链非编码RNABANCR(BRAF-activated long non-coding RNA),由丝氨酸/苏氨酸蛋白激酶(BRAF)激活,研究表明BANCR在... 长链非编码RNA(lncRNA)是一种不具有蛋白质编码能力的长链RNA,在基因表达的转录和转录后调控中发挥关键作用。新近发现的长链非编码RNABANCR(BRAF-activated long non-coding RNA),由丝氨酸/苏氨酸蛋白激酶(BRAF)激活,研究表明BANCR在人类恶性肿瘤中呈现显著性差异表达,其在甲状腺癌中主要作为致癌基因,发挥诱导肿瘤细胞增殖、抑制凋亡及激活自噬等作用。 展开更多
关键词 甲状腺癌 非编码RNA 苏氨酸蛋白激酶 肿瘤细胞增殖 基因表达 LONG BRAF 差异表达
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Design and preliminary results of beam return on of high power ion source
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作者 谢亚红 胡纯栋 +8 位作者 蒋才超 潘军军 赵远哲 梁立振 韦江龙 刘胜 许永建 谢远来 刘智民 《等离子体科学与技术:英文版》 SCIE EI CAS CSCD 2019年第10期73-76,共4页
Long pulse operation of high power ion source is the requirement of fusion science research on neutral beam injector. A breakdown of accelerator column is drastically increased when operating with high beam energy and... Long pulse operation of high power ion source is the requirement of fusion science research on neutral beam injector. A breakdown of accelerator column is drastically increased when operating with high beam energy and long beam duration. To extend the pulse length, which was stopped with every breakdown so far, the beam re-starting technology was developed and utilized. As a result, the voltage drop of every power supply due to breakdown was recovered within a time of 90 ms and beam pulse length was extended much longer than the case before this improvement. The details of the beam re-starting technology and the preliminary results were presented in this manuscript. 展开更多
关键词 ion source ACCELERATOR BEAM re-turn on long pulse operation
Long non-coding RNA highly up-regulated in liver cancer promotes exosome secretion 预览
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作者 Shun-Qi Cao Hong Zheng +4 位作者 Bao-Cun Sun Zheng-Lu Wang Tao Liu Dong-Hui Guo Zhong-Yang Shen 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第35期5283-5299,共17页
BACKGROUND Highly upregulated in liver cancer (HULC) is a long non-coding RNA (lncRNA) which has recently been identified as a key regulator in hepatocellular carcinoma (HCC) progression. However, its role in the secr... BACKGROUND Highly upregulated in liver cancer (HULC) is a long non-coding RNA (lncRNA) which has recently been identified as a key regulator in hepatocellular carcinoma (HCC) progression. However, its role in the secretion of exosomes from HCC cells remains unknown. AIM To explore the mechanism by which HULC promotes the secretion of exosomes from HCC cells. METHODS Serum and liver tissue samples were collected from 30 patients with HCC who had not received chemotherapy, radiotherapy, or immunotherapy before surgery. HULC expression in serum exosomes and liver cancer tissues of patients was measured, and compared with the data obtained from healthy controls and tumor adjacent tissues. The effect of HULC upregulation in HCC cell lines and the relationship between HULC and other RNAs were studied using qPCR and dualluciferase reporter assays. Nanoparticle tracking analysis was performed to detect the quantity of exosomes.RESULTS HULC expression in serum exosomes of patients with HCC was higher than that in serum exosomes of healthy controls, and HULC levels were higher in liver cancer tissues than in tumor adjacent tissues. The expression of HULC in serum exosomes and liver cancer tissues correlated with the tumor-node-metastasis (TNM) classification, and HULC expression in tissues correlated with that in serum exosomes. Upregulation of HULC promoted HCC cell growth and invasion and repressed apoptosis. Notably, it also facilitated the secretion of exosomes from HCC cells. Moreover, qPCR assays showed that HULC repressed microRNA-372-3p (miR-372-3p) expression. We also identified Rab11a as a downstream target of miR-372-3p. Dual-luciferase reporter assays suggested that miR-372-3p could directly bind both HULC and Rab11a. CONCLUSION Our findings illustrate the importance of the HULC/miR-372-3p/Rab11a axis in HCC and provide new insights into the molecular mechanism regulating the secretion of exosomes from HCC cells. 展开更多
关键词 Long NON-CODING RNA EXOSOMES HEPATOCELLULAR carcinoma miR-372-3p Rab11a
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Post-synthesis phase and shape evolution of CsPbBr3 colloidal nanocrystals: The role of ligands
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作者 Elisabetta Fanizza Francesca Cascella +10 位作者 Davide Altamura Cinzia Giannini Annamaria Panniello Leonardo Triggiani Francesca Panzarea Nicoletta Depalo Roberto Grisorio Gian Paolo Suranna Angela Agostiano M.Lucia Curri Marinella Striccoli 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期1155-1166,共12页
The surface chemistry of colloidal cesium lead bromide (CsPbBr3) nanocrystals is decisive in determining the stability and the final morphology of this class of materials,characterized by ionic structure and a high de... The surface chemistry of colloidal cesium lead bromide (CsPbBr3) nanocrystals is decisive in determining the stability and the final morphology of this class of materials,characterized by ionic structure and a high defect tolerance factor.Here,the high sensitivity of purified colloidal nanocubes of CsPbBr3 to diverse environmental condition (solvent dilution,ageing,ligands post synthetic treatment) in ambient atmosphere is investigated by means of a comprehensive morphological (electron microscopy),structural (θ/2θ X-ray diffraction (XRD) and grazing incidence wide angle scattering (GIWAXS)),and spectroscopic chemical (1H nuclear magnetic resonance (NMR),nuclear Overhauser effect spectroscopy (NOESY),absorption and emission spectroscopy) characterization.The aging and solvent dilution contribute to modify the nanocrystal morphology,due to a modification of the ligand dynamic.Moreover,we establish the ability of aliphatic carboxylic acids and aikyl amines ligands to induce,even in a post preparative process at room temperature,structural,morphological and spectroscopic variations.Upon post synthesis alkyl amine addition,in particular of oleyl amine and octyl amine,the highly green emitting CsPbBr3 nanocubes effectively tum into one-dimensional (1 D) thin tetragonal nanowires or lead halide deficient rhombohedral zero-dimensional (0D) Cs4PbBr6 structures with a complete loss of fluorescence.The addition of an alkyl carboxylic acid,as oleic and nonanoic acid,produces the transformation of nanocubes into still emitting orthorombic two-dimensional (2D) nanoplates.The acid/base equilibrium between the native and added ligands,the edsorbed/free ligands dynamic in solution and the ligand solubility in non-polar solvent contribute to render CsPbBr3 particularly sensitive to environmental and processing conditions and,therefore prone to undergo to structural,morphological and,hence spectroscopic,transformations. 展开更多
关键词 lead HALIDE PEROVSKITE NANOCRYSTALS surface chemistry LIGANDS EQUILIBRIA long TERM stability
LSTM neural network for solar radio spectrum classification
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作者 Long Xu Yi-Hua Yan +3 位作者 Xue-Xin Yu Wei-Qiang Zhang Jie Chen Ling-Yu Duan 《天文和天体物理学研究:英文版》 SCIE CAS CSCD 2019年第9期137-148,共12页
A solar radio spectrometer records solar radio radiation in the radio waveband. Such solar radio radiation spanning multiple frequency channels and over a short time period could provide a solar radio spectrum which i... A solar radio spectrometer records solar radio radiation in the radio waveband. Such solar radio radiation spanning multiple frequency channels and over a short time period could provide a solar radio spectrum which is a two dimensional image. The vertical axis of a spectrum represents frequency channel and the horizontal axis signifies time. Intrinsically, time dependence exists between neighboring columns of a spectrum since solar radio radiation varies continuously over time. Thus, a spectrum can be treated as a time series consisting of all columns of a spectrum, while treating it as a general image would lose its time series property. A recurrent neural network(RNN) is designed for time series analysis. It can explore the correlation and interaction between neighboring inputs of a time series by augmenting a loop in a network.This paper makes the first attempt to utilize an RNN, specifically long short-term memory(LSTM), for solar radio spectrum classification. LSTM can mine well the context of a time series to acquire more information beyond a non-time series model. As such, as demonstrated by our experimental results, LSTM can learn a better representation of a spectrum, and thus contribute better classification. 展开更多
关键词 DEEP learning long SHORT-TERM memory(LSTM) CLASSIFICATION SOLAR radio SPECTRUM SOLAR BURST detection
Maintaining a Balance China's desert communities promote viable and sustainable approach to desertification control
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作者 Li Xiaoyu 《中国与非洲:英文版》 2019年第6期14-17,共4页
Li Long is a 39-year-old doctor in Beijing. He still remembers sandstorms ravaging the Chinese capital during spring when he was a university student about 20 years ago.“On the streets everyone had to wear a mask or ... Li Long is a 39-year-old doctor in Beijing. He still remembers sandstorms ravaging the Chinese capital during spring when he was a university student about 20 years ago.“On the streets everyone had to wear a mask or a scarf to cover their noses and mouths. The sand was not only a menace outside, but it also blew into people's houses. One of the biggest hazards was that it disturbed visibility which played havoc with traffic on the roads. It gave an impression of the end of the world," he recalled.Yet, in recent years, sand and dust storms have rarely been seen in Beijing. It is no longer a major concern for local residents like Li. In the 1950s, there was an average of 56 sand or dust storms per year sweeping across the city. In 2017, that number dropped to seven. 展开更多
关键词 Li LONG Beijing
Spatial Pattern Difference of Contribution between Short and Long-duration Heavy Rainfall to Total Heavy Rainfall in China from 1961 to 2015 预览
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作者 Kong Feng 《气象与环境研究:英文版》 CAS 2019年第4期51-60,共10页
Many regions are pounded with heavy rainfall, causing flood, casualties, property damage and severe destruction to ecosystem in multiple urban areas. Frequent occurrence of extremely heavy precipitation event under th... Many regions are pounded with heavy rainfall, causing flood, casualties, property damage and severe destruction to ecosystem in multiple urban areas. Frequent occurrence of extremely heavy precipitation event under the background of global climate change has caused terrible harm on economic and social development, life security, ecosystem, etc.;brought profound impact on sustainable development of disaster area;become a key factor of global and regional disasters and environmental risk;and been widely concerned by academic circle and all sectors of the society. So severe disasters caused by extreme precipitation events have attracted more and more attention, while the relationship between heavy rainfall with different duration and total heavy rainfall has become the hottest scientific frontier issue. Contribution of heavy rainfall with different duration to the total heavy rainfall has significant spatial differences. Here we used daily rainfall data from 1961 to 2015 of 659 meteorological stations in China. When the rainfall is greater than 50 mm in 24 hours, that is a heavy rainfall event. Heavy rainfall only lasting one day is defined as short- duration heavy rainfall, while heavy rainfall lasting more than two days is defined as long-duration heavy rainfall. Results indicated that: on the basis of duration days defined long-duration heavy rainfall, on the spatial distribution, total rainfall, total heavy rainfall and short-duration heavy rainfall showed "increasing-decreasing-increasing" from the southeast coast to northwest inland in China from 1961 to 2015, and on the whole meteorological station with increasing trend predominant. In the meantime, long-duration heavy rainfall showed "increasing-decreasing" spatial pattern, and on the whole meteorological station with decreasing trend predominant. We detected that there was a belt of becoming drought from northeast to southwest. The contribution of total heavy rainfall to total rainfall as well as long-duration heavy rainfall to total heavy rainfall showed " 展开更多
关键词 Precipitation CONTRIBUTION Spatial DIFFERENCE Long and short-duration HEAVY RAINFALL Total HEAVY RAINFALL China
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