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Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging 预览
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作者 Hiroshi Nakanishi 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期25-29,共5页
Interleukin-1βis a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease,Parkinson’s disease,stroke an... Interleukin-1βis a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease,Parkinson’s disease,stroke and persistent pain.Activated microglia are the main cellular source of interleukin-1βin the brain.Cathepsin B is associated with the production and secretion of interleukin-1βthrough pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the phagolysosomes.The leakage of cathepsin B from the endosomal-lysosomal system during aging is associated with the proteolytic degradation of mitochondrial transcription factor A,which can stabilize mitochondrial DNA.Therefore,microglial cathepsin B could function as a major driver for inflammatory brain diseases and brain aging.Orally active and blood-brain barrier-permeable specific inhibitors for cathepsin B can be potentially effective new pharmaceutical interventions against inflammatory brain diseases and brain aging. 展开更多
关键词 BRAIN aging caspase-1 CATHEPSIN B INFLAMMATORY BRAIN diseases INTERLEUKIN-1Β microglia mitochondrial transcription FACTOR A neuroinflammation nuclear factor-κB oxidative stress
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Bone marrow-derived mesenchymal stem cell transplantation attenuates overexpression of inflammatory mediators in rat brain after cardiopulmonary resuscitation 预览
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作者 Qing-Ming Lin Xia-Hong Tang +2 位作者 Shi-Rong Lin Ben-Dun Chen Feng Chen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期324-331,共8页
Emerging evidence suggests that bone marrow-derived mesenchymal stem cell transplantation improves neurological function after cardiac arrest and cardiopulmonary resuscitation;however, the precise mechanisms remain un... Emerging evidence suggests that bone marrow-derived mesenchymal stem cell transplantation improves neurological function after cardiac arrest and cardiopulmonary resuscitation;however, the precise mechanisms remain unclear. This study aimed to investigate the effect of bone marrow-derived mesenchymal stem cell treatment on expression profiles of multiple cytokines in the brain after cardiac arrest and cardiopulmonary resuscitation. Cardiac arrest was induced in rats by asphyxia and cardiopulmonary resuscitation was initiated 6 minutes after cardiac arrest. One hour after successful cardiopulmonary resuscitation, rats were injected with either phosphate-buffered saline(control) or 1 × 10~6 bone marrow-derived mesenchymal stem cells via the tail vein. Serum S100 B levels were measured by enzyme-linked immunosorbent assay and neurological deficit scores were evaluated to assess brain damage at 3 days after cardiopulmonary resuscitation. Serum S100 B levels were remarkably decreased and neurological deficit scores were obviously improved in the mesenchymal stem cell group compared with the phosphate-buffered saline group. Brains were isolated from the rats and expression levels of 90 proteins were determined using a RayBio Rat Antibody Array, to investigate the cytokine profiles. Brain levels of the inflammatory mediators tumor necrosis factor-α, interferon-γ, macrophage inflammatory protein-1α, macrophage inflammatory protein-2, macrophage inflammatory protein-3α, macrophage-derived chemokine, and matrix metalloproteinase-2 were decreased ≥ 1.5-fold, while levels of the anti-inflammatory factor interleukin-10 were increased ≥ 1.5-fold in the mesenchymal stem cell group compared with the control group. Donor mesenchymal stem cells were detected by immunofluorescence to determine their distribution in the damaged brain, and were primarily observed in the cerebral cortex. These results indicate that bone marrow-derived mesenchymal stem cell transplantation attenuates brain damage induced by cardiac arrest and 展开更多
关键词 antibody array ASPHYXIA brain damage cardiac arrest CARDIOPULMONARY RESUSCITATION global cerebral ischemia inflammatory mediator mesenchymal stem cell NEUROLOGICAL DEFICIT score S100B
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Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease 预览
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作者 Viktor Limanskiy Arpita Vyas +1 位作者 Lakshmi Shankar Chaturvedi Dinesh Vyas 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第18期2177-2187,共11页
The molecular scalpel of clustered regularly interspersed short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) technology may be sharp enough to begin cutting the genes implicated in inflammatory bowel ... The molecular scalpel of clustered regularly interspersed short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) technology may be sharp enough to begin cutting the genes implicated in inflammatory bowel disease (IBD) and consequently decrease the 6.3 billion dollar annual financial healthcare burden in the treatment of IBD. For the past few years CRISPR technology has drastically revolutionized DNA engineering and biomedical research field. We are beginning to see its application in gene manipulation of sickle cell disease, human immunodeficiency virus resistant embryologic twin gene modification and IBD genes such as Gatm (Glycine amidinotransferase, mitochondrial), nucleotide-binding oligomerization domain-containing protein 2, KRT12 and other genes implicated in adaptive immune convergence pathways have been subjected to gene editing, however there are very few publications. Furthermore, since Crohn’s disease and ulcerative colitis have shared disease susceptibility and share genetic gene profile, it is paramount and is more advantageous to use CRISPR technology to maximize impact. Although, currently CRISPR does have its limitations due to limited number of specific Cas enzymes, off-target activity, protospacer adjacent motifs and crossfire between different target sites. However, these limitations have given researchers further insight on how to augment and manipulate enzymes to enable precise gene excision and limit crossfire between target sites. 展开更多
关键词 Clustered regularly interspersed short palindromic REPEATS INFLAMMATORY BOWEL DISEASE Crohn’s DISEASE Ulcerative colitis GENE excision GENE EDITING GENE therapy Financial impact of INFLAMMATORY BOWEL DISEASE on healthcare Clustered regularly interspersed short palindromic REPEATS crossfire
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The Relevance of Serum Cystatin C Level of Different Classification of Atrial Fibrillation 预览
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作者 Yuqing Duan Jianhui Xu +2 位作者 Wei Hu Peng Li Rui Li 《临床医学国际期刊(英文)》 2019年第8期404-412,共9页
Objective: To investigate the relationship between serum level of cystatin C (Cys-C) and AF (atrial fibrillation) and its clinical classification. Method: From January 2017 to April 2019, 168 cases of Xiaogan Central ... Objective: To investigate the relationship between serum level of cystatin C (Cys-C) and AF (atrial fibrillation) and its clinical classification. Method: From January 2017 to April 2019, 168 cases of Xiaogan Central Hospital were chosen as the object of this study. The subjects were divided into 86 patients with AF and 82 patients in the control group. The AF group was divided into paroxysmal AF group (29 cases), persistent AF group (27 cases) and permanent AF group (29 cases) according to the European atrial fibrillation management guidelines and the North America Society of Pacing and Electrophysiology (NASPE) arrhythmia group organized the categorization of AF. Results: Compared with the control group, the level of the serum Cys-C was significantly higher in the AF group, the difference was statistically significant (P Conclusion: Serum Cys-C level in atrial fibrillation group is significantly higher than the control group, there are differences between different atrial fibrillation clinical classification, its level increased with duration of atrial fibrillation. Serum Cys-C level and inflammatory markers CRP, WBC and neutrophilic granulocyte percentage were positively correlated, indicating that serum cystatin C is associated with chronic inflammation, involved in the occurrence of atrial fibrillation, maintain and recurrence. Logistic analysis showed that the serum cystatin C level could be used as an independent predictor of atrial fibrillation when other factors were corrected. 展开更多
关键词 CYSTATIN C ATRIAL FIBRILLATION INFLAMMATORY
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Study on the relationship between nonresolving inflammation and tumor 预览
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作者 Jin-Feng Liu 《精准医学研究》 2019年第3期66-71,共6页
Due to persistent or low-intensity stimulation,tissue cells are in a state of injury for a long time,and the inflammatory state continues,eventually leading to nonresolving inflammation.In this nonresolving inflammati... Due to persistent or low-intensity stimulation,tissue cells are in a state of injury for a long time,and the inflammatory state continues,eventually leading to nonresolving inflammation.In this nonresolving inflammation,various inflammatory mediators and inflammatory cells act on tissue cells,and tumors are easily induced.Further,the unique microenvironment of the tumor further aggravates the development of uncontrolled inflammation.Eventually a vicious circle is formed.In this paper,we explored the mechanism of inflammatory mediators,inflammatory cells and tumors in nonresolving inflammation from the relationship between nonresolving inflammation and tumors,and provided some new ideas for the prevention and treatment of tumors. 展开更多
关键词 Nonresolving INFLAMMATION TUMOR INFLAMMATORY MEDIATOR INFLAMMATORY CELL
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Evaluation of Tp-e Interval and Tp-e/QTc Ratio among Patients with Steady State Sickle Cell Disease 预览
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作者 Olawale Mathias Akinlade Adeseye Abiodun Akintunde +4 位作者 Olatunde Peter Olabode Lawrence A. Olatunji Oluwaseun Oyetope Akinpelu Ayodele Olufemi Soladoye Oladimeji George Opadijo 《心血管病(英文)》 2019年第6期425-436,共12页
Sickle cell disease (SCD) has been regarded as an inflammatory and pro-?coagulatory disease with profound cardiovascular abnormalities including propensity for ventricular arrhythmogenesis. Tp-e and Tpe/QTc ratio howe... Sickle cell disease (SCD) has been regarded as an inflammatory and pro-?coagulatory disease with profound cardiovascular abnormalities including propensity for ventricular arrhythmogenesis. Tp-e and Tpe/QTc ratio however has?been proposed as better indicators of arrythmogenesis and has?been shown to be prolonged in many inflammatory conditions and correlate with levels of inflammatory markers. However, correlation between Tpe/QTc ratio and the level of highly sensitive C-reactive protein (hs-CRP) and plasminogen activator inhibitor (PAI) have not been reported in SCD. This study aims at evaluating Tp-e Interval and Tp-e/QTc ratio among steady state Sickle cell disease patients in relationship to the degree of anaemia, inflammatory and profibrotic markers.?Methodology:?A cross-sectional hospital-based study comprises?30 sickle cell anaemia patients in steady state with an?equal number of controls having genotype HbAA and HbAS respectively.Clinical, laboratory and ECG parameters were obtained.?Results:?A total of 90 participants?are?with mean age 24.2?±?5.6. The study showed that sickle cell disease patient had significantly lower level of PCV and higher level of PAI, platelet and total white cell count (p value??0.05). C-reactive protein was also higher in them. 76.7% of HbSS patients had abnormal ECG. QTc and Tp-e were also prolonged in sickle cell disease patients compared with controls. An association was found between the level of PCV, PAI and prolonged Tp-e and QTc.?Conclusion:?Sickle cell disease patients have higher levels of inflammatory markers and abnormal ECG patterns are common in them. Moreover, the levels of these inflammatory markers correlate with Tp-e parameters. 展开更多
关键词 ELECTROCARDIOGRAPHY ARRHYTHMOGENESIS SICKLE Cell ANAEMIA INFLAMMATORY
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早产的发生机制及预测因子新进展 预览
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作者 付锦娴 陈友鹏 陈新 《暨南大学学报:自然科学与医学版》 CAS CSCD 北大核心 2019年第4期334-338,共5页
早产是导致围生儿死亡及新生儿疾病的重要因素,是临床工作中频繁出现的挑战与难题.影响早产的因素众多,生理或心理因素、先天或后天因素都可能在妊娠过程中引致早产.早产的机制更复杂,可能与炎症机制、内分泌系统的调节、母体基因背景... 早产是导致围生儿死亡及新生儿疾病的重要因素,是临床工作中频繁出现的挑战与难题.影响早产的因素众多,生理或心理因素、先天或后天因素都可能在妊娠过程中引致早产.早产的机制更复杂,可能与炎症机制、内分泌系统的调节、母体基因背景等有关.目前临床上预测早产的手段较为局限,综合早产的病因机制及预测因子,查找更多的早产预测因子,为早产的诊断与防治提供依据. 展开更多
关键词 早产 免疫失衡 炎症 蜕膜早衰 预测因子
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TSG-6蛋白在疾病模型中的研究进展
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作者 侯林林 高艳霞 《临床急诊杂志》 CAS 2019年第9期696-700,共5页
肿瘤坏死因子α刺激基因-6(tumor necrosis factor a stimulated gene 6,TSG-6)蛋白是一种35 kd的炎症诱导蛋白,最初是通过对TNF刺激的人FS-4成纤维细胞制备的cDNA文库进行鉴别筛选而发现的,位于人染色体2q23.3,mRNA全长1440 bp,其启动... 肿瘤坏死因子α刺激基因-6(tumor necrosis factor a stimulated gene 6,TSG-6)蛋白是一种35 kd的炎症诱导蛋白,最初是通过对TNF刺激的人FS-4成纤维细胞制备的cDNA文库进行鉴别筛选而发现的,位于人染色体2q23.3,mRNA全长1440 bp,其启动子序列中存在白细胞介素(interleukin,IL)和核因子的结合位点。 展开更多
关键词 TSG-6蛋白 透明质酸 炎症反应 间充质干细胞
Protective Effect of Bacillus subtilis Peptidoglycan (PG) on β-conglycinin-induced Intestinal Epithelial Cells Damage of Juvenile Carp (Cyprinus carpio) 预览
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作者 Zhang Tiantian Yin Haicheng Huang Wei 《动物与饲料科学:英文版》 CAS 2019年第2期56-61,共6页
[Objective] The paper was to investigate the protective effects of different concentrations of Bacillus subtilis peptidoglycan(PG) on β-conglycinin-induced inflammatory injury in intestinal epithelial cells of juveni... [Objective] The paper was to investigate the protective effects of different concentrations of Bacillus subtilis peptidoglycan(PG) on β-conglycinin-induced inflammatory injury in intestinal epithelial cells of juvenile carp(Cyprinus carpio).[Method] In 24-cell microplates, the intestinal epithelial cells(IECs) of juvenile carp were primarily cultured for 72 h at 26°C and 6% CO2, and then the IECs were randomly divided into6 groups with 4 replicates per group. One of the six groups was set as negative control group, and the other groups were all supplemented with 1.0 mg/mL β-conglycinin in culture medium to establish inflammatory injury. At 24 h post induction, the culture media were changed into B. subtilis PG culture media with the concentrations of 0(positive control group), 0.15, 0.30, 0.45 and 0.60 mg/mL, respectively. The samples were collected to measure the antioxidant and anti-inflammatory indices at 12, 24 and 36 h post culture.[Result]β-conglycinin exposure significantly decreased the activity of ASA, AHR, SOD, CAT, GPx, and increased the PC content and the mRNA expression of inflammatory cytokines(IL-1β, IL-8, TNF-α1,IL-10 and TGF-β). At 12, 24 and 36 h post PG treatment, the activities of ASA, AHR, SOD, CAT, GPx and the content of PC in cells decreased in a dose-dependent manner;the mRNA levels of IL-1β, IL-8 and TNF-α1 were down-regulated and those of IL-10 and TGF-β were up-regulated.[Conclusion] Different concentrations of B. subtilis PG could protect IECs oxidative damage induced by β-conglycinin and improve the antioxidant capacity of IECs. High concentration of PG could improve the anti-inflammatory ability of IECs by inhibiting inflammatory factors and promoting the gene expression of anti-inflammatory cytokines. 展开更多
关键词 CARP (Cyprinus carpio) Bacillus subtilis PG Β-CONGLYCININ Intestinal epithelial cell (IECs) Antioxidant Inflammatory factor
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Characterization of inflammatory factor-induced changes in mesenchymal stem cell exosomes and sequencing analysis of exosomal microRNAs 预览
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作者 Chen Huang Wen-Feng Luo +8 位作者 Yu-Feng Ye Li Lin Zhe Wang Ming-Hua Luo Qi-De Song Xue-Ping He Han-Wei Chen Yi Kong Yu-Kuan Tang 《世界干细胞杂志:英文版(电子版)》 2019年第10期859-890,共32页
BACKGROUND Treatments utilizing stems cells often require stem cells to be exposed to inflammatory environments,but the effects of such environments are unknown.AIM To examine the effects of inflammatory cytokines on ... BACKGROUND Treatments utilizing stems cells often require stem cells to be exposed to inflammatory environments,but the effects of such environments are unknown.AIM To examine the effects of inflammatory cytokines on the morphology and quantity of mesenchymal stem cell exosomes(MSCs-exo)as well as the differential expression of microRNAs(miRNAs)in the exosomes.METHODS MSCs were isolated from human umbilical tissue by enzymatic digestion.Exosomes were then collected after a 48-h incubation period in a serum-free medium with one of the following the inflammatory cytokines:None(control),vascular cell adhesion molecule-1(VCAM-1),tumor necrosis factor(TNF)α,and interleukin(IL)6.The morphology and quantity of each group of MSC exosomes were observed and measured.The miRNAs in MSCs-exo were sequenced.We compared the sequenced data with the miRBase and other non-coding databases in order to detect differentially expressed miRNAs and explore their target genes and regulatory mechanisms.In vitro tube formation assays and Western blot were performed in endothelial cells which were used to assess the angiogenic potential of MSCs-exo after inflammatory cytokine stimulation.RESULTS MSCs-exo were numerous,small,and regularly shaped in the VCAM-1 group.TNFαstimulated MSCs to secrete larger and irregular exosomes.IL6 led to a reduced quantity of MSCs-exo.Compared to the control group,the TNFαand IL6 groups had more downregulated differentially expressed miRNAs,particularly angiogenesis-related miRNAs.The angiogenic potential of MSCs-exo declined after IL6 stimulation.CONCLUSION TNFαand IL6 may influence the expression of miRNAs that down-regulate the PI3K-AKT,MAPK,and VEGF signaling pathways;particularly,IL6 significantly down-regulates the PI3K-AKT signaling pathway.Overall,inflammatory cytokines may lead to changes in exosomal miRNAs that abnormally impact cellular components,molecular function,and biological processes. 展开更多
关键词 MESENCHYMAL stem cells EXOSOMES MiRNA INFLAMMATORY CYTOKINES ANGIOGENESIS
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Data mining in Xu Runsan's Traditional Chinese Medicine practice:treatment of chronic pelvic pain caused by pelvic inflammatory disease
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作者 Liu Liuqing Yang Fang +1 位作者 Xin Ling Jing Yan 《中医杂志:英文版》 SCIE CAS CSCD 2019年第3期440-450,共11页
OBJECTIVE:To research the Traditional Chinese Medicine(TCM)practice of Professor Xu Runsan for treatment of chronic pelvic pain(CPP)caused by sequelae of pelvic inflammatory disease(SPID)by data mining.METHODS:The med... OBJECTIVE:To research the Traditional Chinese Medicine(TCM)practice of Professor Xu Runsan for treatment of chronic pelvic pain(CPP)caused by sequelae of pelvic inflammatory disease(SPID)by data mining.METHODS:The medical records of inpatients at China-Japan Friendship Hospital confirmed to have CPP caused by SPID were collected(274 visits in total).The data extracted from the medical records were analyzed by frequency statistics,correlation analyses,cluster analyses,and complex network analyses.RESULTS:The most frequently used medicines were warm medicines,bitter medicines,and medicines distributed to the liver meridian.The most common medicinal combinations were Chishao(Radix Paeoniae Rubra)plus Huangqi(Radix Astragali Mongolici)plus Sanqi(Radix Notoginseng)and Ezhu(Rhizoma Curcumae Phaeocoulis);Guizhi(Ramulus Cinnamomi)plus Fuling(Poria)and Chishao(Radix Poeoniae Rubra);and Chaihu(Radix Bupleuri Chinensis)plus Zhishi(Fructus Aurantii Immaturus)and Gancao(Radix Glycyrrhizae).The most frequently used medicines were divided into four groups according to their efficacy;i.e.,medicines that could(a)warm meridians and free collateral vessels,(b)regulate Qi and free collateral vessels,(c)fortify the spleen and nourish blood and Qi,and(d)tonify Qi and activate blood.The most commonly used formulations were Guizhi FulingPill and Sini Powder.The core medicines extracted based on complex network analyses were Chishao(Radix Poeoniae Rubra),Sanqi(Radix Notoginseng),Hua ngqi(Radix Astragali Mongolica),Danshen(Radix Salviae Miltiorrhizae),Ezhu(Rhizoma Curcumae Phaeocaulis), Gancao(Radix Glycyrrhizae),Chaihu(Radix Bupleuri Chinensis),Guizhi(Romulus Cinnomomi),Shuizhi(Hirudo), Fuling(Poria),and Zhishi(Fructus Aurantii Immaturus).CONCLUSION:According to the TCM practice of Professor Xui,treatment of CPP caused by SPID should focus on dissolving stasis and obstructions using medicines that can activate blood,resolve stasis,regulate Qi,and dissipate adhesions.His prescriptions are often based on Guizhi Fuling Pill and Sini Powder. 展开更多
关键词 PELVIC PAIN PELVIC inflammatory disease Drugs Chinese HERBAL Cluster ANALYSIS Complex network ANALYSIS
Sexual health and fertility for individuals with inflammatory bowel disease 预览
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作者 Romain Leenhardt Pauline Rivière +4 位作者 Patrick Papazian Isabelle Nion-Larmurier Guillaume Girard David Laharie Philippe Marteau 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第36期5423-5433,共11页
The impact of a chronic disease such as inflammatory bowel disease (IBD) on sexual functioning and body image can significantly impair the quality of life of patients. This review considers the sexual and fertility as... The impact of a chronic disease such as inflammatory bowel disease (IBD) on sexual functioning and body image can significantly impair the quality of life of patients. This review considers the sexual and fertility aspects of IBD patients and their daily management. Modern IBD healthcare management should include appropriate communication on sexuality and consider psychological, physiological, and biological issues. Patients with IBD have less children than the general population, and voluntary childlessness is frequent. The most influential factors reported by IBD patients who experience fertility alteration are psychological and surgery-related problems. Pregnancy is a major concern for patients, and any pregnancy for IBD patients should be closely followed-up to keep the chronic disease in a quiescent state. Preconceptional consultation is of great help. 展开更多
关键词 Inflammatory BOWEL DISEASE Crohn’s DISEASE ULCERATIVE COLITIS FERTILITY Pregnancy SEXUALITY
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Inflammatory pseudotumor-like follicular dendritic cell sarcoma:A brief report of two cases 预览
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作者 Bi-Xi Zhang Zhi-Hong Chen +2 位作者 Yu Liu Yuan-Jun Zeng Yan-Chun Li 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第12期1231-1239,共9页
BACKGROUND Follicular dendritic cell(FDC)sarcoma/tumor is a rare malignant tumor of follicular dendritic cells,which is considered a low-grade sarcoma that can involve lymph nodes or extranodal sites.Conventional FDC ... BACKGROUND Follicular dendritic cell(FDC)sarcoma/tumor is a rare malignant tumor of follicular dendritic cells,which is considered a low-grade sarcoma that can involve lymph nodes or extranodal sites.Conventional FDC sarcomas are negative for Epstein-Barr virus(EBV),whereas the inflammatory pseudotumorlike variant consistently shows EBV in the neoplastic cells.CASE SUMMARY We report two cases of inflammatory pseudotumor-like FDC sarcoma in the liver that received 3D laparoscopic right hepatectomy and open right hepatectomy separately.CONCLUSION EBV probe-based in situ hybridization and detection of immunohistochemical markers of FDC play an important role in the diagnosis and differential diagnosis of inflammatory pseudotumor-like FDC sarcoma.Complete surgical excision combined with regional lymphadenectomy may be effective in reducing the postoperative recurrence and metastasis and improving long-term survival rates. 展开更多
关键词 Inflammatory pseudotumor-like follicular dendritic cell sarcoma Epstein-Barr virus LIVER SPLEEN Case report
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超声影像技术在炎性关节病变诊疗中的应用研究 预览
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作者 李红琼 《影像研究与医学应用》 2019年第11期98-99,共2页
目的:探究分析超声影像技术在炎性关节病变当中的应用价值以及诊断效果。方法:选取我院在2016年—2018年期间我院所收治的共计100名关节炎性病变的患者作为研究对象,将所有的患者按照临床上的诊断方式不同分为对照组和观察组。其中对照... 目的:探究分析超声影像技术在炎性关节病变当中的应用价值以及诊断效果。方法:选取我院在2016年—2018年期间我院所收治的共计100名关节炎性病变的患者作为研究对象,将所有的患者按照临床上的诊断方式不同分为对照组和观察组。其中对照组人数共计50名实施X射线诊断方式进行,观察组人数共计50名实施超声诊断方式。对比两组患者在临床上的诊断准确率情况。结果:通过对比分析来看,观察组患者实施超声诊断方式后,医生能够更加清楚的对患者关节周围软组织异常情况进行分析,发现局部所存在的活动性炎症,同时有效的对患者肌肉骨骼显示,相比于X射线检查诊断准确率方面显著提升,差异具有统计学意义(P <0.05)。结论:在当前阶段针对炎性关节炎来说,通过实施正确的超声诊断方式能够有效的提升实际的诊断效果,对于患者的诊断准确率具有积极的意义和作用,可在临床上进行推广。 展开更多
关键词 超声诊断 炎性 关节炎
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Probiotic Mixture VSL#3 Alleviates Dextran Sulfate Sodium-induced Colitis in Mice by Downregulating T Follicular Helper Cells 预览
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作者 Xiao-jing LIU Ran YU Kai-fang ZOU 《当代医学科学(英文)》 SCIE CAS 2019年第3期371-378,共8页
Clinical trials have shown beneficial effects of probiotics on inflammatory bowel diseases (IBD), although the exact mechanism remains unknown. VSL#3, a mixture of 8 probiotic bacteria, has been confirmed to have adju... Clinical trials have shown beneficial effects of probiotics on inflammatory bowel diseases (IBD), although the exact mechanism remains unknown. VSL#3, a mixture of 8 probiotic bacteria, has been confirmed to have adjunctive therapeutic effects on colitis. T follicular helper (Tfh) cells, a new separate subset of CD4+ T helper cells, have been proved to play a vital role in autoimmunity. The present study aimed to identify the beneficial effect of the probiotic mixture VSL#3 on the mouse model of colitis by regulating Tfh cells. Dextran sulfate sodium (DSS) was used to induce chronic colitis in C57BL/6 mice. VSL#3 (3x109 live bacteria) was given to C57BL/6 mice every other day for 60 days by gavage. The disease activity index (DAI), histological activity index (HAI), colon length and myeloperoxidase (MPO) activity were detected. Immunofluorescence was used to visualize the location of Tfh cells. Immunoglobulins, Tfh cells and plasma cells were quantified by enzyme-linked immunosorbent assay (ELISA), flow cytometry, real-time PCR or Western blotting. The results showed that after DSS treatment, the humoral immunity was disordered in C57BL/6 mice, with increased IgM, IgG and IgA levels in colonic mucus and increased Tfh cells in mesenteric lymph nodes (MLN). VSL#3 treatment showed anti-inflammatory effects as evidenced by reduced DAI score, HAI score and MPO activity. IgM, IgG and IgA levels were significantly reduced in colon mucus, and the number of Tfh cells was markedly decreased in MLN after VSL#3 treatment. It was concluded that VSL#3 alleviates DSS-induced colitis by downregulating Tfh cells, and Tfh cells may become a potential therapeutic target for IBD. 展开更多
关键词 T FOLLICULAR HELPER cells PROBIOTICS VSL#3 HUMORAL immunity inflammatory BOWEL disease
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沙美特罗替卡松对慢性阻塞性肺疾病急性加重期患者炎症因子和肺功能的影响
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作者 王美玲 秦晓鸥 +2 位作者 王春荣 陈云 于会云 《国际呼吸杂志》 2019年第12期911-915,共5页
目的探讨沙美特罗替卡松(舒利迭)对慢性阻塞性肺疾病急性加重期(AECOPD)患者血清炎症因子和肺功能指标的影响。方法选取2016年3月至2018年3月涿州市医院AECOPD患者100例,依据随机数字表法分为常规治疗组(常疗组)和舒利迭治疗组(舒疗组)... 目的探讨沙美特罗替卡松(舒利迭)对慢性阻塞性肺疾病急性加重期(AECOPD)患者血清炎症因子和肺功能指标的影响。方法选取2016年3月至2018年3月涿州市医院AECOPD患者100例,依据随机数字表法分为常规治疗组(常疗组)和舒利迭治疗组(舒疗组),每组50例.常疗组给予常规治疗,舒疗组在此基础上给予舒利迭治疗,比较两组血清炎症因子白细胞介素6 (IL-6)、可溶性E-选择素(sE-SLT)、可溶性细胞间黏附分子-1(sICAM-1)、第1秒用力呼气容积(FEV1、FEV1占预计值百分比(FEV1%pred)、FVC、COPD评估测试评分(CAT)、圣乔治呼吸问卷(SGRQ)、不良反应的差异。结果常规治疗组和舒疗组治疗后IL-6、sE-SLT、sICAM-1、CAT、SGRQ明显低于治疗前,舒疗组治疗后IL-6、sE-SLT、sICAM-1、CAT、SGRQ明显低于常疗组,常疗组和舒疗组治疗后FEV1、FEV1%pred. FVC明显高于治疗前,舒疗组治疗后FEV1、FEV1%pred、FVC明显高于常疗组,差异有统计学意义(P<0.05);常疗组和舒疗组总不良反应发生率(心跳加快、头晕、恶心、呕吐等)比较,差异无统计学意义(P>0.05)。结论舒利迭可有效改善AECOPD患者炎症状态和肺功能,有利于提高患者的病情控制效果及生活质量.且安全性好。 展开更多
关键词 舒利迭:肺疾病.慢性阻塞性.急性加重期 炎症 肺功能
Understanding the importance of autophagy in human diseases using Drosophila
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作者 Arindam Bhattacharjee Aron Szabo +2 位作者 Tamas Csizmadia Hajnalka Laczko-Dobos Gabor Juhasz 《遗传学报:英文版》 SCIE CAS CSCD 2019年第4期157-169,共13页
Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in the pathogenesis of various human diseases, either positively or negatively impacting disease outcomes depending on the s... Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in the pathogenesis of various human diseases, either positively or negatively impacting disease outcomes depending on the specific context. The majority of medical conditions including cancer, neurodegenerative diseases, infections and immune system disorders and inflammatory bowel disease could probably benefit from therapeutic modulation of the autophagy machinery. Drosophila represents an excellent model animal to study disease mechanisms thanks to its sophisticated genetic toolkit, and the conservation of human disease genes and autophagic processes. Here, we provide an overview of the various autophagy pathways observed both in flies and human cells(macroautophagy, microautophagy and chaperone-mediated autophagy), and discuss Drosophila models of the above-mentioned diseases where fly research has already helped to understand how defects in autophagy genes and pathways contribute to the relevant pathomechanisms. 展开更多
关键词 DROSOPHILA NEURODEGENERATION Alzheimer’s DISEASE Parkinson’s DISEASE Cancer Inflammatory bowel DISEASE AUTOPHAGY
High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis 预览
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作者 Noel Pin Vieito Sara Zarraquinos Joaquín Cubiella 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第19期2383-2401,共19页
BACKGROUND The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of... BACKGROUND The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of patients presenting lower bowel symptoms. Therefore, the National Institute for Health and Care Excellence has recommended the adoption of FIT in primary care to guide referral for suspected CRC in low-risk symptomatic patients using a 10 μg Hb/g faeces threshold. Nevertheless, it is unknown whether FIT′s accuracy remains stable throughout the broad spectrum of possible symptoms. AIM To perform a systematic review and meta-analysis to assess FIT accuracy for CRC detection in different clinical settings. METHODS A systematic literature search was performed using MEDLINE and EMBASE databases from inception to May 2018 to conduct a meta-analysis of prospective studies including symptomatic patients that evaluated the diagnostic accuracy of quantitative FIT for CRC detection. Studies were classified on the basis of brand, threshold of faecal haemoglobin concentration for a positive test result, percentage of reported symptoms (solely symptomatic, mixed cohorts) and CRC prevalence (< 2.5%,≥ 2.5%) to limit heterogeneity and perform subgroup analysis to assess the influence of clinical spectrum on FIT′s accuracy to detect CRC. RESULTS Fifteen cohorts including 13073 patients (CRC prevalence 0.4% to 16.8%) were identified. Pooled estimates of sensitivity for studies using OC-Sensor at 10 μg Hb/g faeces threshold (n = 10400) was 89.6%[95% confidence interval (CI): 82.7% to 94.0%). However, pooled estimates of sensitivity for studies formed solely by symptomatic patients (n = 4035) and mixed cohorts (n = 6365) were 94.1%(95%CI: 90.0% to 96.6%) and 85.5%(95%CI: 76.5% to 91.4%) respectively (P < 0.01), while there were no statistically significant differences between pooled sensitivity of studies with CRC prevalence < 2.5%(84.9%, 95%CI: 73.4% to 92.0%) and ≥ 2.5%(91.7%, 95%CI: 83.3% to 96.1%)(P = 0.25 展开更多
关键词 BOWEL DISEASE Colorectal cancer Diagnostic ACCURACY FAECAL HAEMOGLOBIN FAECAL immunochemical TEST FAECAL occult blood TEST Inflammatory BOWEL DISEASE Significant colonic lesion
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Effect of argatroban on neurological function in patients with acute cerebral infarction and its mechanism
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作者 Mei-Qi Di Ling-Ling Hu +2 位作者 Shu-Hua Gui Xiao-Jing Yin Chao-Sheng Li 《海南医科大学学报(英文版)》 2019年第3期56-60,共5页
Objective: Analyze the effect of argatroban on neurological function in patients with acute cerebral infarction and explore its possible mechanisms. Methods: From August 2015 to August 2017, 140 patients with acute ce... Objective: Analyze the effect of argatroban on neurological function in patients with acute cerebral infarction and explore its possible mechanisms. Methods: From August 2015 to August 2017, 140 patients with acute cerebral infarction who were admitted to the Department of Neurology in our hospital were divided into a control group and an observation group according to the lottery method, with 70 cases in each group. Patients in the conventional group received routine treatment. Patients in the treatment group received routine treatment plus argatroban. The changes of neurological function, coagulation function and inflammatory factors were observed in the two groups. Result: Before treatment, there were no significant differences in neurological function parameters, coagulation function indexes and inflammatory factors between the two groups. After treatment, the neurological function indexes NT-proBNP, NPY and S-100β levels, coagulation function index FIB level, inflammatory factor indicators MMP-9, Lp-PLA2 and Hcy, vascular endothelial function index ET levels decreased, coagulation Functional indicators PT, TT and APTT are both elevated, and NO and CGRP levels are elevated. The levels of NT-proBNP, NPY and S-100β, FIB level, MMP-9, Lp-PLA2 and Hcy, ET levels in the treatment group were lower than those in the conventional group, while the levels of PT, TT and APTT levels, and NO and CGRP levels were higher than the conventional group. Conclusion: Argatroban treatment can significantly improve neurological function in patients with acute cerebral infarction. The possible mechanism is to improve coagulation function, vascular endothelial function and relieve inflammatory stress response. 展开更多
关键词 ARGATROBAN NEUROLOGICAL FUNCTION COAGULATION FUNCTION INFLAMMATORY FACTORS
Fatigue in children and adolescents with inflammatory bowel disease 预览
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作者 Els Van de Vijver Ann Van Gils +3 位作者 Laura Beckers Yannick Van Driessche Nicolette Dorien Moes Patrick Ferry van Rheenen 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第5期632-643,共12页
AIM To identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease(IBD).METHODS We performed an electronic search in Medline and EMBASE from their inception... AIM To identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease(IBD).METHODS We performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term"fatigue"or the related keywords"physical impairment"and"inflammatory bowel disease"with the filter"child"(age 0-18 years).Cross-sectional and case-control studies were included.We restricted our search to studies published in English.We used the PRISMA checklist and flow diagram.Duplicate articles were manually deleted in End Note.To identify further relevant studies,we checked the reference lists of the selected articles.RESULTS We identified 149 papers,of which 19 were retrieved for full text review.Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure.Eight papers focused on the desired topic and were discussed in the final analysis.A lack of uniformity of outcome measures made the pooling of data impossible.In all but one study,questionnaires were used to evaluate fatigue.In the remaining study,an accelerometer was used to measure daily activities,sleeping time and their relationships with fatigue in a more quantifiable manner.Adolescents with IBD are significantly more fatigued than healthy controls.In addition to active disease,increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue.Quantitative measurement of physical activity in patients with Crohn's disease showed a reduction in the number of steps per day,and patients with ulcerative colitis had a shorter duration of physical activity during the day.CONCLUSION Fatigue in pediatric IBD is related to a combination of biological,functional and behavioral factors,which should all be taken into account when managing fatigue. 展开更多
关键词 Adolescents Children FATIGUE INFLAMMATORY BOWEL disease PHYSICAL IMPAIRMENT SLEEP
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