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Primary Hepatic Angiosarcoma Revealed by a Hemorrhagic Parietal Metastasis about a Case in Lomé 预览
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作者 Mamadou Diallo Mazamaesso Tchaou +2 位作者 Issifou Boube Lantam Sonhaye Komlavi Adjenou 《放射学期刊(英文)》 2019年第3期176-180,共5页
Angiosarcoma is a malignant tumor developed at the expense of endothelial cells. Primary hepatic localization is rare. Chronic toxic exposure is classically described as responsible for the development of this tumor. ... Angiosarcoma is a malignant tumor developed at the expense of endothelial cells. Primary hepatic localization is rare. Chronic toxic exposure is classically described as responsible for the development of this tumor. The diagnosis is based on the pathological examination. The authors report a case of hepatic angiosarcoma in a 28-year-old woman who received for a thoraco-abdominal hemorrhagic parietal secondary lesion. A thoracic abdominal and parietal ultrasound was performed followed by thoraco-abdomino-pelvic CT. The diagnosis was confirmed by histology. Palliative treatment combining surgery and chemotherapy has been established with a poor prognosis. 展开更多
关键词 Hepatic ANGIOSARCOMA Ultrasound CT-SCAN METASTASIS Histology
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Histological Profile of ENT and Cervico-Facial Lesions in Mali 预览
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作者 Djibril Samaké Youssouf Sidibé +14 位作者 Fatogoma Issa Koné Hamidou Niangaly Kolo Diamouténé N’faly Konaté Ngniée Tafo Ghislaine Neuilly Nagnouma Camara Kassim Diarra Abdoul Wahab Haidara Siaka Soumaoro Boubacary Guindo Kadiatou Singaré Samba Karim Timbo Mohamed Kéï ta Alhousseini Ag Mohamed 《耳鼻喉(英文)》 2019年第1期61-69,共9页
Aim: Our goal was to determine the histological profile of ENT lesions. Method: We carried out a retrospective and descriptive study in the ENT department and Cervico-Facial Surgery at the university hospital center G... Aim: Our goal was to determine the histological profile of ENT lesions. Method: We carried out a retrospective and descriptive study in the ENT department and Cervico-Facial Surgery at the university hospital center Gabriel Touré (MALI) from 1995 to 2014. It made it possible to collect 450 cases. Result: We found a male predominance;51.11% or a sex ratio of 1.04. The mean age of patients was 38.04 years with a standard deviation of 19.49 years and extremes of 3 months and 91 years. Benign tumors were the most frequent (154 cases or 34.22%) including 75 cases of adenomas and 43 cases of papillomas. Cancers accounted for 48.11% (or 153 cases) of all tumors and 34% of lesions. Carcinomas accounted for 81.04%, malignant lymphomas 13.72% and sarcomas 5.22% of cases. Among the 140 cases (31.11%) of inflammatory pseudotumors, we found 12 cases of tuberculosis and 15 cases of rhinoscleroma. Three (3) cases of dysplasia were observed. Conclusion: Interest should be focused on histology in order to initiate appropriate therapy. 展开更多
关键词 ENT LESIONS HISTOLOGY MALI
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Endoscopic Radial Artery Harvest in Coronary Artery Bypass Surgery: Clinicopathological Evaluation 预览
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作者 Amir Mohamed Kamelia Velikova +7 位作者 Ahmed Nabil Amr Algarhy Mohamed Badawy Adel Maher Ashraf Abdelsalam Jamal Al-Fadhli Riyad Tarazi Nael Al-Sarraf 《心血管外科国际期刊(英文)》 2019年第2期15-23,共9页
Objectives: The radial artery is used as a second arterial conduit in coronary artery bypass surgery. However, concerns exist about the thermal injury incurred to the radial artery during endoscopic harvest. We sought... Objectives: The radial artery is used as a second arterial conduit in coronary artery bypass surgery. However, concerns exist about the thermal injury incurred to the radial artery during endoscopic harvest. We sought to assess this effect both histologically and radiologically. Methods: From February 2015 to March 2016, 50 consecutive patients undergoing coronary artery bypass surgery utilizing endoscopically harvested radial artery were prospectively studied. Computerized tomography coronary angiography scan was performed randomly in 8 patients who also had their respective radial artery analyzed histologically at the time of harvest. Standard coronary angiography was also performed in 4 additional patients driven by symptoms recurrence. Results: All patients were available for follow up at 1 year following the surgery. There was no mortality during follow-up. Three patients (6%) developed transient complications in the harvest arm which resolved. All radial arteries were patent on follow-up imaging. Histological examination showed integrity of the arterial wall, intact endothelial lining, patent lumens and no significant pathological abnormalities. Conclusion: The use of endoscopic radial artery harvest was associated with few self-limiting morbidities and excellent patency rates. In addition, there was no evidence of any thermal or traumatic injuries sustained to the radial arteries when examined histologically. The use of endoscopically harvested radial arteries appears safe with excellent results. 展开更多
关键词 Radial ARTERY ENDOSCOPIC HARVEST Coronary ARTERY BYPASS HISTOLOGY
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Histopathological Evaluation of Prevalent <i>H. pylori</i>Induced Gastro Intestinal Diseases According to Updated Sydney Classification 预览
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作者 Samreen Soomro Tazeen Mustansir Talat Mirza 《生物科学与医学(英文)》 2019年第5期195-201,共7页
Objective: To determine the prevalence of H. pylori induced gastritis and its association with development of chronic inflammation and carcinoma with reference to updated Sydney classification, to ensure the proper di... Objective: To determine the prevalence of H. pylori induced gastritis and its association with development of chronic inflammation and carcinoma with reference to updated Sydney classification, to ensure the proper diagnosis and timely treatment. Methods: This was a cross sectional study conducted at the Department of Pathology, Dow Diagnostic Reference and Research Laboratory for the year 2018. Analysis of about 726 gastric biopsy specimens was performed to identify the epidemiological status of the disease. On the other hand, 100 of the specimens were analysed according to Sydney classification to ensure the accurate diagnosis of the gastritis and related disorders. Out of 726 biopsy samples positive samples for carcinoma were investigated in detail histological features. Giemsa stain was used to visualize the h pylori bacteria and the sections of biopsies were subjected to haematoxylin and eosin staining for histological analysis. Results: Out of 727 cases, H. pylori was found in 492 (67.8%) patients. About 1.79% (13) cases were identified as adenocarcinoma, 0.27% (2) squamous cell carcinoma and 0.13% (1) as B cell non Hodgkin lymphoma. Results of Sydney classification. The degree of chronic inflammatory activity was 57% mild;38% moderate and 3% severe out of a total of 67% cases in an active phase of Hp gastritis. Hp-associated gastritis was the most common form of chronic gastritis, without intestinal metaplasia and with mild activity. The association of h pylori with mild inflammation and Neutrophilic infiltrates of the lamina propria, pits, or surface epithelium was statistically significant (p value Conclusion: The frequency of H. pylori infection is common in our population but the infection is mild to moderate and its Sydney classification reveals that early diagnosis may prevent the later complication. 展开更多
关键词 Helicobacter PYLORI SYDNEY CLASSIFICATION Histology Gastritis
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Animal models of acute gastric mucosal injury: Macroscopic and microscopic evaluation 预览
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作者 Sandra Simoes Rui Lopes +3 位作者 Maria Celeste Dias Campos Maria Joao Marruz Maria Eugénia Meirinhos da Cruz Luísa Corvo 《动物模型与实验医学(英文)》 CSCD 2019年第2期121-126,共6页
Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely ... Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely used rat models of acute gastric ulcer, the ethanol‐induced ulcer and the indomethacin‐induced ulcer. These two models are compared in terms of macroscopic and microscopic features. Experimentally, ethanol was given orally in a single dose and indomethacin was subcutaneously injected into male Wistar rats. After ulcerative challenges, the stomachs were removed and visually inspected. Anti‐ulcerative drugs were used to validate the models. Histological analysis of the stomachs determined the microscopic score. The methodology used for model evaluation applied to macroscopic and microscopic gastric lesions. With these methods it was possible to induce lesions in the gastric mucosa. Microscopic evaluation permitted assessment of the inflammatory and apoptotic impact in the mucosa not observable by macroscopic evaluation. Groups of animals were treated with two standard drugs: sulcralfate suspension or lansoprazole solution. Both drugs reduced macroscopic and microscopic lesions, particularly the hemorrhagic ones. Both models induced acute gastric mucosal injury and no single evaluation method can address all the aspects of the pathology of gastric lesions. As a complement to macroscopic evaluation, microscopy appears to be a relevant tool to selectively identify specific aspects of the development of mucosal injury, quantify the extent of lesions, and contribute to an appropriate interpretation of results. The score systems established here offer a reliable method for testing antiulcer drugs. 展开更多
关键词 animal models gastric ULCER HISTOLOGY PRE-CLINICAL assays
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孕激素受体在不同发育期牦牛乳腺组织内的分布及表达
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作者 方莉莉 安玲 +10 位作者 荆海霞 俞红贤 张勤文 李莉 魏青 王昕玥 李凤 陈勇豪 万瑞东 杨玉莹 李广祯 《黑龙江畜牧兽医》 CAS 北大核心 2019年第11期141-146,183共7页
为揭示不同发育期牦牛乳腺组织内孕激素受体(progesterone receptor,PR)的分布及蛋白水平的表达,试验应用SP免疫组织化学方法和Image Pro Plus 6.0分析软件检测不同发育期牦牛乳腺内PR的分布情况,并采用Western-blot技术对乳腺组织内的P... 为揭示不同发育期牦牛乳腺组织内孕激素受体(progesterone receptor,PR)的分布及蛋白水平的表达,试验应用SP免疫组织化学方法和Image Pro Plus 6.0分析软件检测不同发育期牦牛乳腺内PR的分布情况,并采用Western-blot技术对乳腺组织内的PR蛋白含量进行半定量测定。结果表明:PR阳性物质主要见于乳腺腺泡上皮细胞、导管上皮细胞、血管内皮细胞及小叶间结缔组织细胞的细胞核中,偶见胞质着色。PR阳性物质平均光密度在整个乳腺发育过程都呈现高-低-高的趋势,青春期PR阳性物质数高于其他几个期,差异显著(P<0.05);妊娠期、泌乳早期、泌乳中期和静止期PR阳性物质数比较差异显著(P<0.05);其中妊娠期和静止期的PR阳性物质数均高于泌乳早期和泌乳中期,但妊娠期和静止期PR阳性物质数差异不显著(P>0.05),泌乳早期和泌乳中期PR阳性物质数差异不显著(P>0.05)。PR阳性物质数的分布表明PR可促进导管分支和腺泡发育。PR蛋白相对表达水平在不同发育期牦牛乳腺组织内明显不同,青春期PR蛋白相对表达水平明显高于其他几个期,泌乳早期和泌乳中期PR蛋白相对表达很少,而静止期开始大量表达。提示在牦牛不同发育期,PR蛋白在乳腺发育及泌乳生物学中可能发挥不同的功能。 展开更多
关键词 牦牛 乳腺 不同发育期 孕激素受体 组织学 蛋白
成人腰椎软骨终板的组织学特征 预览
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作者 孙毅 梁彦超 +2 位作者 武峰 蒋安龙 闫景龙 《脊柱外科杂志》 2019年第1期47-50,共4页
目的探讨健康成人腰椎软骨终板组织学特征。方法选取18具新鲜成人尸体腰椎标本,死亡原因为车祸伤或意外,无腰椎外伤和糖尿病。从8个不同区域取材,制备软骨终板样本,利用高敏感测高仪测量软骨终板厚度,通过显微镜观察经HE染色后终板的组... 目的探讨健康成人腰椎软骨终板组织学特征。方法选取18具新鲜成人尸体腰椎标本,死亡原因为车祸伤或意外,无腰椎外伤和糖尿病。从8个不同区域取材,制备软骨终板样本,利用高敏感测高仪测量软骨终板厚度,通过显微镜观察经HE染色后终板的组织学特征。结果不同区域软骨终板厚度差异有统计学意义(P<0.05),终板厚度为0.696~1.045mm,后区下部终板最厚,中央区上部最薄。HE染色结果显示,软骨终板的细胞密度比髓核和纤维环的细胞密度高,软骨终板中央区和侧区的胶原纤维分别比髓核和纤维环组织中的胶原纤维更加紧密。结论腰椎不同区域软骨终板厚度不同,其组织学特征与椎间盘的营养供应相关。 展开更多
关键词 腰椎 椎间盘退行性变 组织学
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颗粒肋软骨游离移植隆鼻术后的组织学检测 预览
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作者 李洁 杨晓宁 +4 位作者 梁雪冰 李芯 王春虎 王克明 马继光 《组织工程与重建外科》 2019年第2期89-91,共3页
目的通过组织学观察,探讨颗粒肋软骨游离移植隆鼻术后在体内的转归。方法对2015年1月至2017年12月在我院行颗粒肋软骨游离移植隆鼻术的患者进行回顾性分析,总结修复手术的原因并将二次修复手术中采集的颗粒肋软骨行组织学检测。结果颗... 目的通过组织学观察,探讨颗粒肋软骨游离移植隆鼻术后在体内的转归。方法对2015年1月至2017年12月在我院行颗粒肋软骨游离移植隆鼻术的患者进行回顾性分析,总结修复手术的原因并将二次修复手术中采集的颗粒肋软骨行组织学检测。结果颗粒肋软骨游离移植隆鼻术后要求二次修复的原因包括:过矫、移植物显形、移植物移位和鼻背偏斜。修复手术中采集的颗粒软骨呈瓷白色软骨样外观;组织学检测可见典型的软骨陷窝样结构,胞外基质含量丰富。结论经组织学检测证实,颗粒肋软骨游离移植隆鼻术后在体内能够保持原有的软骨特性。 展开更多
关键词 颗粒肋软骨 隆鼻术 组织学
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口腔专业《组织学与胚胎学》整合课程建设与实践 预览
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作者 张代军 李玲 《青岛大学学报(医学版)》 CAS 2019年第4期496-498,共3页
目的探讨口腔医学专业《组织学与胚胎学》整合课程的建设与实践效果。方法通过更新教学理念、重组和优化课程内容、创新教学方法和手段、完善考核与评价方法、建设优质的教学资源、打造优秀师资队伍等措施,对口腔医学专业《组织学与胚... 目的探讨口腔医学专业《组织学与胚胎学》整合课程的建设与实践效果。方法通过更新教学理念、重组和优化课程内容、创新教学方法和手段、完善考核与评价方法、建设优质的教学资源、打造优秀师资队伍等措施,对口腔医学专业《组织学与胚胎学》整合课程进行建设,并经过2年的教学实践。结果口腔医学专业《组织学与胚胎学》整合课程教学减少了教学内容的重复,增加了医学生自主学习的主动性,培养并提高了学生发现问题和解决问题的能力,为学生学习后续口腔医学专业课程打下了坚实的理论基础。结论《组织学与胚胎学》整合课程在口腔医学专业教学中具有可行性。 展开更多
关键词 口腔医学 组织学 胚胎学 课程 教学方法
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Post-Mortem MRI and Histopathology in Neurologic Disease:A Translational Approach
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作者 Laura E.Jonkman Boyd Kenkhuis +1 位作者 Jeroen J.G.Geurts Wilma D.J.van de Berg 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第2期229-243,共15页
In this review, combined post-mortem brain magnetic resonance imaging(MRI) and histology studies are highlighted, illustrating the relevance of translational approaches to de?ne novel MRI signatures of neuropathologic... In this review, combined post-mortem brain magnetic resonance imaging(MRI) and histology studies are highlighted, illustrating the relevance of translational approaches to de?ne novel MRI signatures of neuropathological lesions in neuroin?ammatory and neurodegenerative disorders. Initial studies combining post-mortem MRI and histology have validated various MRI sequences,assessing their sensitivity and speci?city as diagnostic biomarkers in neurologic disease. More recent studies have focused on de?ning new radiological(bio)markers and implementing them in the clinical(research) setting. By combining neurological and neuroanatomical expertise with radiological development and pathological validation,a cycle emerges that allows for the discovery of novel MRI biomarkers to be implemented in vivo. Examples of this cycle are presented for multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury.Some applications have been shown to be successful, while others require further validation. In conclusion, there is much to explore with post-mortem MRI and histology studies, which can eventually be of high relevance for clinical practice. 展开更多
关键词 MRI Histology Biomarkers Multiple SCLEROSIS Alzheimer’s DISEASE Parkinson’s DISEASE
大西洋鲑在封闭循环水养殖模式下的生长和性腺发育研究 预览
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作者 徐世宏 王彦丰 +4 位作者 刘清华 刘鹰 王顺奎 徐滢轩 李军 《海洋科学》 CAS 北大核心 2019年第11期97-102,共6页
本研究探讨了在封闭循环水养殖模式下大西洋鲑(Salmo salar)的生长发育模式,对封闭循环水系统养殖的大西洋鲑重要生长数量性状进行生物学测量,并跟踪性腺发育状况。本研究自2012年1月通过封闭循环水系统进行大西洋鲑养殖,经过周年养殖,... 本研究探讨了在封闭循环水养殖模式下大西洋鲑(Salmo salar)的生长发育模式,对封闭循环水系统养殖的大西洋鲑重要生长数量性状进行生物学测量,并跟踪性腺发育状况。本研究自2012年1月通过封闭循环水系统进行大西洋鲑养殖,经过周年养殖,体质量平均达到1194.42g,体长平均达到417.00mm,体高平均达到100.58mm,体宽平均达到53.52mm,少数个体在养殖10个月后性腺发育较快,性腺质量达到9.76g,性腺指数达到1.31%。本研究的研究结果为建立大西洋鲑标准化循环水养殖系统积累资料。 展开更多
关键词 大西洋鲑(Salmo salar) 封闭循环水 生长 性腺发育 组织学切片
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植物抗感品种受病原侵染的差异研究进展
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作者 秦丹丹 高利 +2 位作者 陈万权 刘太国 刘博 《中国植保导刊》 北大核心 2019年第1期19-24,共6页
研究植物病原对植物抗感品种的侵染差异,对致病机理解析和抗病资源利用均有重要意义。目前,国内外关于这方面的研究主要集中在以下几方面,即选取代表性品种对比分析不同抗感品种受侵染后的细胞组织学变化,研究与抗病性相关的酶,通过基... 研究植物病原对植物抗感品种的侵染差异,对致病机理解析和抗病资源利用均有重要意义。目前,国内外关于这方面的研究主要集中在以下几方面,即选取代表性品种对比分析不同抗感品种受侵染后的细胞组织学变化,研究与抗病性相关的酶,通过基因组学技术揭示抗感品种的相关机理等,这些研究将为新的防治方法奠定理论基础。 展开更多
关键词 侵染差异 组织学 蛋白质 基因组学 显微镜
组织学中石蜡切片制作的注意事项 预览
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作者 秦永亭 秦双立 +1 位作者 倪杰 王士珍 《基层医学论坛》 2019年第20期2894-2895,共2页
石蜡切片技术是组织学中一种常用的制片技术,也是当前医学生学习组织学应掌握的一门实验技术。然而,由于石蜡切片制作过程复杂、耗时长、安全性差等原因导致石蜡切片质量优劣不一,同时也影响到了学生实验课的效果。为此,我们结合实验室... 石蜡切片技术是组织学中一种常用的制片技术,也是当前医学生学习组织学应掌握的一门实验技术。然而,由于石蜡切片制作过程复杂、耗时长、安全性差等原因导致石蜡切片质量优劣不一,同时也影响到了学生实验课的效果。为此,我们结合实验室多年的教学经验,对石蜡切片制作的注意事项进行了总结,为在教学和科研中制作出高效、合格的石蜡切片提供参考。 展开更多
关键词 组织学 石蜡切片 制作 注意事项
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直肠癌手术相关腹膜后自主神经的筋膜解剖学观察 被引量:1
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作者 梁志平 杨永裕 +2 位作者 武天同 陈壁俊 张策 《中国临床解剖学杂志》 CSCD 北大核心 2019年第2期121-125,共5页
目的从临床解剖学和组织学角度进一步阐明盆自主神经的筋膜层次。方法选取7具尸体标本和52例接受腹腔镜直肠癌切除手术的病人,观察其自主神经与肾前筋膜-骶前筋膜的关系。切取尸体降乙结肠系膜与主髂动脉之间、直肠系膜与骶骨骨膜之间... 目的从临床解剖学和组织学角度进一步阐明盆自主神经的筋膜层次。方法选取7具尸体标本和52例接受腹腔镜直肠癌切除手术的病人,观察其自主神经与肾前筋膜-骶前筋膜的关系。切取尸体降乙结肠系膜与主髂动脉之间、直肠系膜与骶骨骨膜之间的腹膜后组织做组织学检查。结果解剖学观察显示,腹主动脉丛、上腹下丛、腹下神经、下腹下丛位于肾前筋膜-骶前筋膜后外侧。组织学检查显示:神经纤维位于筋膜后,部分较细的纤维位于筋膜内。结论自主神经位于肾前筋膜-骶前筋膜后外侧。保持这一筋膜的完整性,是直肠癌手术中保护自主神经的解剖学基础和基本方法。 展开更多
关键词 自主神经 筋膜 解剖学 组织学 直肠癌
评估心肌组织特征的磁共振成像技术及临床应用
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作者 杨帆 张璋 +1 位作者 任雯 李东 《第二军医大学学报》 CAS CSCD 北大核心 2019年第3期243-249,共7页
随着心脏磁共振(CMR)技术的发展,CMR已从最开始的钆造影剂延迟增强(LGE)序列发展到多模态成像,是目前评价心肌组织学异常的成像方法之一。CMR能够提供丰富的心肌解剖学和功能学信息,可从定性到定量、从宏观到微观甚至分子学水平精确评... 随着心脏磁共振(CMR)技术的发展,CMR已从最开始的钆造影剂延迟增强(LGE)序列发展到多模态成像,是目前评价心肌组织学异常的成像方法之一。CMR能够提供丰富的心肌解剖学和功能学信息,可从定性到定量、从宏观到微观甚至分子学水平精确评估心肌的组织学异常。不同CMR技术如LGE序列、mapping序列、弥散加权成像和磁共振波谱等,在疾病诊疗和机制探究方面各具优势,对临床中深入认识心肌疾病并及时干预具有重要意义。本文综述了这些心肌组织特征的CMR成像方法在评估不同类型心肌疾病中的优势及临床应用。 展开更多
关键词 磁共振成像 心肌 组织学 心肌疾病
鼻咽后部筋膜间隙MRI表现 预览
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作者 梁久平 彭华荣 +2 位作者 赵双全 宋建勋 李恒国 《中国医学影像技术》 CSCD 北大核心 2019年第6期833-836,共4页
目的探讨MR显示鼻咽后部筋膜间隙组织结构的价值。方法对20名健康志愿者行鼻咽部MRT1W及轴位高分辨T2W平扫,观察鼻咽后部筋膜间隙的MRI表现。选取以甲醛溶液固定的成年人标本5具,采集头颈部MRI,再冷冻后制成横切面标本,将咽后软组织部... 目的探讨MR显示鼻咽后部筋膜间隙组织结构的价值。方法对20名健康志愿者行鼻咽部MRT1W及轴位高分辨T2W平扫,观察鼻咽后部筋膜间隙的MRI表现。选取以甲醛溶液固定的成年人标本5具,采集头颈部MRI,再冷冻后制成横切面标本,将咽后软组织部分进行组织切片、HE染色,对照观察鼻咽后部筋膜间隙的MRI及镜下表现。结果鼻咽上份层面鼻咽后部组织从前向后均可见黏膜、咽颅底筋膜、椎前肌及枕骨斜坡,椎前肌内信号不均匀,后缘与枕骨后基底部及斜坡上份分界无法清晰分辨,前缘光滑并可见连续清晰低信号筋膜;标本对应层面镜下表现为咽颅底筋膜、颊咽筋膜、翼状筋膜及椎前筋膜所构成的筋膜层。鼻咽下份层面椎前肌信号均匀,后缘与骨质间隙内见连续的高信号脂肪层,前缘光滑但筋膜不能完整清晰显示;标本对应层面镜下为咽缩肌前缘纤维膜明显变薄,系咽缩肌将其与后方筋膜(颊咽筋膜、翼状筋膜及椎前筋膜)分开所致。结论MRI可清晰显示鼻咽后部筋膜层、椎前肌及脂肪间隙结构。 展开更多
关键词 鼻咽 筋膜 磁共振成像 组织学
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小黄鱼(Larimichthys polyactis)消化道形态与组织学结构特征及其消化酶活性的研究 预览
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作者 陈寅儿 郑学斌 +5 位作者 高心明 王景倩 谢庆平 詹炜 楼宝 竺俊全 《海洋与湖沼》 CAS CSCD 北大核心 2019年第5期1116-1126,共11页
为了解小黄鱼(Larimichthys polyactis)消化道结构特点及其功能与食性的相关性,采用解剖、石蜡切片、AB-PAS反应及酶活检测技术,观察研究了小黄鱼消化道的形态及组织学结构、黏液细胞定位及消化酶活性。结果显示:消化道由口咽腔(舌)、... 为了解小黄鱼(Larimichthys polyactis)消化道结构特点及其功能与食性的相关性,采用解剖、石蜡切片、AB-PAS反应及酶活检测技术,观察研究了小黄鱼消化道的形态及组织学结构、黏液细胞定位及消化酶活性。结果显示:消化道由口咽腔(舌)、食道、胃及肠构成,食道粗短,胃卜型,肠呈“S”型弯曲,肠指数为0.63;舌上皮中分布有味蕾及少量各型黏液细胞。食道、胃及肠均由黏膜层、黏膜下层、肌层及外膜组成;食道含初级及次级突起,分别被覆复层扁平及单层柱状上皮,大量黏液细胞分布于复层上皮内,以Ⅱ型为主。胃内胃腺发达,分布有大量Ⅰ及Ⅱ型黏液细胞;胃中蛋白酶活性较高。肠上皮为单层柱状上皮,上皮层分布有各型黏液细胞,以Ⅱ型为主;肠道肌层厚度、黏膜褶皱高度及黏液细胞总密度由前往后递增;肠道中胰蛋白酶、脂肪酶、淀粉酶及碱性磷酸酶活性较高,且后肠高于前、中肠。小黄鱼消化道形态、组织结构及酶活性分布特点与其肉食食性相适应,口咽腔(舌)及食道上皮具有较好的保护作用,胃在蛋白质消化吸收方面发挥重要作用,肠道在蛋白质、脂类、糖类、无机盐等物质的消化吸收方面起重要作用。 展开更多
关键词 小黄鱼(Larimichthys polyactis) 解剖学 组织学 黏液细胞 消化酶 食性
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小鼠颈脊髓半侧挫伤模型的建立及其组织学特点
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作者 黄志平 林俊育 +6 位作者 刘俊豪 李榕 刘雅普 刘祺 朱青安 黄祖成 吴晓亮 《中国临床解剖学杂志》 CSCD 北大核心 2019年第1期40-44,共5页
目的建立基于位移控制的C57/6J小鼠C5脊髓半侧挫伤模型,观察其脊髓组织学改变。方法 C57BL/6小鼠在麻醉状态下行C5左侧椎板切除术,打击头(直径0.75 mm)对准C5左侧,由电磁伺服材料试验机驱动挫伤脊髓,设定打击位移0.9 mm,打击速度50 mm/... 目的建立基于位移控制的C57/6J小鼠C5脊髓半侧挫伤模型,观察其脊髓组织学改变。方法 C57BL/6小鼠在麻醉状态下行C5左侧椎板切除术,打击头(直径0.75 mm)对准C5左侧,由电磁伺服材料试验机驱动挫伤脊髓,设定打击位移0.9 mm,打击速度50 mm/s。损伤后1周脊髓标本取材,EC染色,作组织学定量分析。结果打击参数结果稳定性与重复性良好。打击位移、打击速度和打击力分别为(0.880±0.035)mm、(48.146±4.367)mm/s、(0.407±0.129)N,损伤中心的脊髓组织学表现为:伤侧脊髓有明显的出血及正常组织结构破坏,脊髓背侧束、脊髓后角和部分前角有破坏;健侧脊髓结构基本保持完整。计算损伤中心平面的残存灰质比例、残存白质比例及损伤面积比例分别为(19±7)%、(88±9)%及(28±4)%。结论本研究成功建立小鼠颈脊髓半侧挫伤模型,此模型具有重复性较好的力学参数,表现出典型的单侧颈脊髓损伤的组织学特征,可为脊髓损伤分子机制和治疗研究奠定基础。 展开更多
关键词 脊髓损伤 半侧挫伤 位移控制 组织学 小鼠
From 2-dimensional to 3-dimensional: Overcoming dilemmas in intestinal mucosal interpretation 预览
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作者 Richard PG Charlesworth Michael N Marsh 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第20期2402-2415,共14页
The purpose of this review is to provide a definitive account of small intestinal mucosal structure and interpretation. The coeliac lesion has been well known, but not well described to date and this review aims to id... The purpose of this review is to provide a definitive account of small intestinal mucosal structure and interpretation. The coeliac lesion has been well known, but not well described to date and this review aims to identify the interpretative difficulties which have arisen over time with the histological assessment of coeliac disease. In early coeliac interpretation, there were significant inaccuracies, particularly surrounding intraepithelial lymphocyte counts and the degree of villous flattening which occurred in the tissue. Many of these interpretive pitfalls are still encountered today, increasing the potential for diagnostic errors. These difficulties are mostly due to the fact that stained 2-dimensional sections can never truly represent the 3-dimensional framework of the intestinal tissue under investigation. Therefore, this review offers a critical account occasioned by these 2-dimensional interpretative errors and which, in our opinion, should in general be jettisoned. As a result, we leave a framework regarding the true 3-dimensional knowledge of mucosal structure accrued over the 70-year period of study, and one which is available for future reference. 展开更多
关键词 COELIAC disease HISTOLOGY Diagnosis 2-dimensional 3-dimensional
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锦江翘嘴鲌性腺发育的组织学研究 预览
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作者 李忠利 巴家文 +2 位作者 魏文燕 蒋天勇 蔡红艳 《大连海洋大学学报》 CAS CSCD 北大核心 2019年第4期519-525,共7页
为研究锦江翘嘴鲌Culter alburnus性腺发育特征,通过生物学解剖和常规石蜡组织切片观察,对沅江支流锦江翘嘴鲌性腺及生殖细胞发育的周年变化特征进行了研究。结果表明:精巢属于小叶型结构,其发育分为6个时期,精母细胞发育分为5个阶段,... 为研究锦江翘嘴鲌Culter alburnus性腺发育特征,通过生物学解剖和常规石蜡组织切片观察,对沅江支流锦江翘嘴鲌性腺及生殖细胞发育的周年变化特征进行了研究。结果表明:精巢属于小叶型结构,其发育分为6个时期,精母细胞发育分为5个阶段,即精原细胞、初级精母细胞、次级精母细胞、精子细胞及精子;雌鱼性腺发育分为6个时期,卵母细胞发育分为6个时相,第Ⅰ时相核仁出现,数量在第Ⅱ和第Ⅲ时相逐渐增多,第Ⅱ时相出现单层滤泡膜和卵黄核,第Ⅲ时相卵黄核消失,滤泡膜分化出两层,液泡和放射带出现,晚期卵黄颗粒可见,第Ⅳ时相卵黄大量积累,液泡被挤压到细胞质外缘,晚期核偏位,第Ⅴ时相细胞质中充满卵黄颗粒,并融合成块状,细胞核消失,卵膜内缘有皮质泡明显可见,第Ⅵ时相未排出的成熟卵以颗粒细胞形式被分解吸收,在第Ⅱ至Ⅵ时相的卵母细胞中都存在退化细胞。研究表明,卵母细胞和精母细胞的发育均表现出不同步特征,本研究结果可为锦江翘嘴鲌的资源保护和人工繁育提供数据参考。 展开更多
关键词 翘嘴鲌 精巢 卵巢 组织学 锦江
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