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药物洗脱球囊和药物洗脱支架对支架内再狭窄的疗效比较 预览
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作者 谢秀峰 张越 曲泽 《中国组织工程研究》 CAS 北大核心 2020年第4期555-560,共6页
背景:国内外一系列的研究显示针对药物洗脱支架内再狭窄病变,药物洗脱球囊和药物洗脱支架优于其他介入方式,但是这两种治疗方式都存在着各自的局限。目的:评价药物洗脱球囊与药物洗脱支架植入治疗药物洗脱支架内再狭窄的疗效。方法:选择... 背景:国内外一系列的研究显示针对药物洗脱支架内再狭窄病变,药物洗脱球囊和药物洗脱支架优于其他介入方式,但是这两种治疗方式都存在着各自的局限。目的:评价药物洗脱球囊与药物洗脱支架植入治疗药物洗脱支架内再狭窄的疗效。方法:选择2016年1月至2017年12月内蒙古医科大学第一附属医院收治的药物洗脱支架内再狭窄患者63例,其中32例进行药物洗脱球囊植入治疗,另31例进行药物洗脱支架植入治疗,记录两组患者介入术前、术后即刻冠状动脉情况,随访1年后冠状动脉造影情况、主要不良心血管事件发生及支架内再狭窄的危险因素分析。研究得到内蒙古医科大学伦理委员会的同意及支持。结果与结论:(1)随访1年,两组支架内最小管腔直径、参考血管直径、支架内晚期管腔丢失比较差异均无显著性意义(P均>0.05),二次再狭窄概率比较差异无显著性意义(18%,16%,P=0.216)。靶病变血运重建发生率比较差异无显著性意义(6%,6%,P=0.513),主要不良心脏事件发生率比较差异无显著性意义(9%,10%,P=0.334);药物洗脱支架组2例发生消化道出血,药物洗脱球囊组未发生消化道出血,两组比较差异有显著性意义(P<0.01);(2)多因素分析发现,吸烟、糖尿病、高同型半胱氨酸血症是支架内再狭窄的危险因素;(3)结果表明,药物洗脱球囊与药物洗脱支架均是治疗支架内再狭窄的理想方法,临床实践中需综合多因素考虑需采取个体化治疗方案。 展开更多
关键词 药物洗脱支架 药物洗脱球囊 支架内再狭窄 经皮冠脉介入治疗 冠状动脉粥样硬化心脏病 高同型半胱氨酸血症 吸烟 糖尿病
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2型糖尿病合并暴发性1型糖尿病一例并文献复习:双重糖尿病?
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作者 金丽霞 刘兆祥 +1 位作者 赵文惠 肖建中 《中华糖尿病杂志》 CAS CSCD 北大核心 2019年第8期537-542,共6页
目的分析2型糖尿病(T2DM)合并暴发性1型糖尿病(FT1DM)与单纯性FT1DM的临床特点。方法报道1例T2DM合并FT1DM的病例,分析其病例特点,并比较文献中21例T2DM合并FT1DM与日本161例单纯性FT1DM及国内70例单纯性FT1DM患者的临床特点,组间比较采... 目的分析2型糖尿病(T2DM)合并暴发性1型糖尿病(FT1DM)与单纯性FT1DM的临床特点。方法报道1例T2DM合并FT1DM的病例,分析其病例特点,并比较文献中21例T2DM合并FT1DM与日本161例单纯性FT1DM及国内70例单纯性FT1DM患者的临床特点,组间比较采用t检验。结果(1)T2DM合并FT1DM患者以男性居多(男女比例14∶7),平均年龄(60.1±11)岁,FT1DM病程(4.4±1.7)d,所有患者胰岛自身抗体[谷氨酸脱羧酶抗体(GADA)、胰岛细胞抗体(ICA)、胰岛素自身抗体(IAA)]阴性。(2)与日本单纯性FT1DM相比,T2DM合并FT1DM患者年龄更大[(60.1±11.8)比(39.1±15.7)岁,P<0.001]、糖化血红蛋白(HbA1c)水平更高(8.2%±1.6%比6.4%±0.9%,P<0.001)、体质指数(BMI)更高[(23.7±5.7)比(20.7±3.9)kg/m2,P=0.032]。(3)与国内单纯性FT1DM相比,差别趋势与日本单纯性FT1DM比较一致。T2DM合并FT1DM患者年龄更大[(60.1±11.8)比(31.7±11.4)岁,P<0.001],HbA1c水平更高(8.2%±1.6%比6.8%±1.1%,P<0.001),同时有更长的病程[(4.4±1.7)比(3.1±2.4)d,P=0.032];BMI差异无统计学意义[(23.7±5.7)比(21.1±3.7)kg/m2,P=0.068]。结论双重糖尿病可以表现为T2DM合并FT1DM,其相较单纯性FT1DM表现为更长的病程、更大年龄、更高的BMI和HbA1c水平。 展开更多
关键词 糖尿病 2型 糖尿病 1型 暴发性1型糖尿病 双重糖尿病
Effectiveness of Clinical Pharmacist Directed-Diabetes Management 预览
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作者 Neha Farheen Tabassum N. Himanandini +3 位作者 Manaal Fathima M. Sankeerthna Nikhil Kumar Vanjari Siva Subrahmanyam Bandaru 《糖尿病(英文)》 2019年第3期137-145,共9页
Objective: The main aim of the study is predominately utilizing clinical pharmacist in the provision of continuing diabetic education programs to emphasize and re-emphasize the importance of risk factors, prevention, ... Objective: The main aim of the study is predominately utilizing clinical pharmacist in the provision of continuing diabetic education programs to emphasize and re-emphasize the importance of risk factors, prevention, adherence to medication and behavioral changes to prevent recurrences of the disease, their progression, and ultimately minimize hospitalization. Specific goals are to improve clinical outcomes for patients with diabetes—to maintain optimal plasma glucose concentrations Fasting, Postprandial Plasma Glucose, and Glycated Hemoglobin. Study design: A prospective interventional study in the Outpatient General Medicine Department, for a period of six months from October 2018 to March 2019. Results: HbA1c levels were reduced from baseline by &minus;1.107 ± 0.8634, Fasting Plasma Glucose levels and Postprandial blood glucose levels were reduced from baseline by &minus;24.2218 ± 5.70352 and &minus;30.1891 ± 1.40592 respectively. Conclusion: A trained clinical pharmacist by providing diabetes education and care can significantly reduce hyperglycemia, thereby improving the quality of life in diabetes patients and ultimately reducing health care costs associated with these morbidities. 展开更多
关键词 DIABETES MELLITUS Clinical PHARMACIST Glycated HEMOGLOBIN FASTING Plasma GLUCOSE Post-Prandial Blood GLUCOSE DIABETES Care and Management
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Cardiac Markers: An Index in the Assessment of Cardiovascular Disease in Diabetic Patients in Bayelsa State, Niger Delta Region, South of Nigeria 预览
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作者 Ferdinand Chukwuma Ezeiruaku 《糖尿病(英文)》 2019年第4期153-166,共14页
Background and Objective: Patients with type 2 Diabetes mellitus (DM) are known to be at risk of developing cardiovascular diseases (CVD). The prevalence and incidence of DM patients with heart diseases is unknown in ... Background and Objective: Patients with type 2 Diabetes mellitus (DM) are known to be at risk of developing cardiovascular diseases (CVD). The prevalence and incidence of DM patients with heart diseases is unknown in Yenagoa and its environ of Bayelsa State, Niger Delta Region of Nigeria. The study, with the tool of cardiac markers, investigated the incidence of CVD in chronic and non-chronic DM patients and compared the prevalence in both male and female subjects with respect to the duration of illness. The study sought to evaluate the diagnostic performance of cardiac markers to evaluate the diabetic subjects and the goals of screening are to improve life expectancy and quality of life by preventing Myocardial infarction (MI) and heart failure through the early detection of significant CVD. Study Design and Methods: A total of 356 type 2 DM patients were recruited for the study. They are diabetic patients that presented with symptoms of CVD. They were grouped into 135 DM patients that have suffered the Diabetes for less than 10 years, 119 for 10 - 20 years and 102 for 21 and above years. The plasma levels of the Cardiac Markers, Troponin I (CTnI), Troponin T (cTnT), Creatine Kinase (CK-MB), Myoglobin (MYO) and Lactate dehydrogenase (LDH) were determined in the subjects. The method of fluorescence immunoassay (FIA) was used in the measurement of CTn1, CTnT and MYO. Enzyme Linked Immunosorbent Assay (ELISA) was used to determine the CK-MB and LDH. Results: Analysis of the results has shown that 14.33% of the studied subjects were diagnosed of various CVD and were statistically significant (p Conclusion: The tools of cardiac markers can be used in the diagnosis/assessment of CVD in type 2 DM patients. The risk of developing CVD is more in females than the male subjects that are suffering from type 2 DM and those with long duration of the illness in Yenegoa, Bayelsa State, Niger Delta Region, South of Nigeria. 展开更多
关键词 Diabetes MELLITUS Cardiovascular Troponins CREATINE Kinase MYOGLOBIN LACTATE DEHYDROGENASE IMMUNOASSAY
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An Optimum Dose of Olive Leaf Extract Improves Insulin Receptor Substrate-1, Tyrosine Kinase, and Glucose Transporters, While High Doses Have Genotoxic and Apoptotic Effects 预览
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作者 Abdurrahim Kocyigit Bur?in Kasap +4 位作者 Eray Metin Guler Humeyra Nur Kaleli Mustafa Kesmen Murat Dikilitas Ersin Karatas 《美国植物学期刊(英文)》 2019年第11期1933-1948,共16页
Type 2 diabetes is the most common type of diabetes. Conventionally many drugs are used for the treatment of diabetes such as biguanides, sulfonylureas, meglitinides, etc. But the desired effective treatment is still ... Type 2 diabetes is the most common type of diabetes. Conventionally many drugs are used for the treatment of diabetes such as biguanides, sulfonylureas, meglitinides, etc. But the desired effective treatment is still not to be achieved. So researches are going on for the development of effective alternative therapy against diabetes. Olive leaves are traditionally used in the treatment of the disease. However, studies on its mechanism of action are not yet enough. The aim of this study was to investigate whether olive leaf extract (OLE) improves insulin receptor substrate-1 (IRS-1), tyrosine kinase (TK), GLUT-2, and GLUT-4. Oleuropein levels were analyzed from OLE obtained by using four different solvents, and the highest content of methanol extract was selected for the study. Different concentrations of OLE (2.5 to 320 μg/mL) were incubated with hepatocellular carcinoma (HepG2) cells for 24 hours. After incubation, cell viability was assessed based on luminometric ATP cell viability assay kit. Intracellular reactive oxygen species (ROS) generating level was detected using 2,7dichlorodihydrofluorescein-diacetate (H2DCF-DA) fluorescent probes. Apoptosis was evaluated by acridine orange/ethidium bromide double staining method. Genotoxicity was evaluated by alkaline single cell gel electrophoresis assay (Comet Assay). Protein expression levels of IRS-1, TK, GLUT-2, and GLUT-4 were analyzed by western blotting technique from the obtained cell lysates. Although an optimum doses of OLE (10 μg/mL) maximally increased cell proliferation, decreased ROS generation improved IRS-1, TK, GLUT-2, and GLUT-4 protein expression levels (about fivefold), higher doses (10 to 320 μg/mL) markedly decreased the cell viability, increased DNA damage, apoptosis and ROS generation in a concentration-dependent manner. OLE can be used in the treatment of type 2 diabetes. However, in order to find the most effective and non-toxic concentration, dose optimization is required. 展开更多
关键词 PHYTOTHERAPY Diabetes MELLITUS OLIVE Leaf Extract Glucose Transporters Insulin Receptors
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新发暴发性1型糖尿病患者胰岛α细胞功能特征研究
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作者 张玲玉 付煜 +5 位作者 谷丽 王悦舒 王静 秦瑶 杨涛 张梅 《中华糖尿病杂志》 CAS CSCD 北大核心 2019年第5期347-352,共6页
目的探讨新发暴发性1型糖尿病(FT1DM)患者起病时胰岛α细胞功能的特征。方法选取2017年10月至2018年7月于南京医科大学第一附属医院符合标准的新诊断FT1DM患者(FT1DM组)4例和经典T1DM患者(经典T1DM组)10例,另招募健康志愿者15名作为健... 目的探讨新发暴发性1型糖尿病(FT1DM)患者起病时胰岛α细胞功能的特征。方法选取2017年10月至2018年7月于南京医科大学第一附属医院符合标准的新诊断FT1DM患者(FT1DM组)4例和经典T1DM患者(经典T1DM组)10例,另招募健康志愿者15名作为健康对照组。收集临床资料,将FT1DM组和经典T1DM组血糖控制在<10 mmol/L后,三组均行100 g标准馒头餐试验(SBMT),检测血糖、C肽及胰高糖素,并以空腹胰高糖素水平为基线,计算SBMT后胰高糖素曲线下增量面积(iAUCglucagon)及C肽曲线下面积(tAUCc-peptide)。各组iAUCglucagon及tAUC c-peptide比较前先行方差齐性检验,方差齐者行单因素方差分析(ANOVA),组间多重比较采用LSD检验;方差不齐者行Brown-Forsythe检验,组间多重比较采用Games-Howell检验。结果(1)各组tAUC c-peptide比较,差异有统计学意义(F=98.343,P<0.001)。FT1DM组tAUC c-peptide低于经典T1DM组[(192.62±68.98)比(1 535.71±199.73)pmol·L^-1·h^-1,qcrit=3.830,P<0.001]及健康对照组[(192.62±68.98)比(6 798.80±541.40)pmol·L^-1·h^-1,qcrit=3.688,P<0.001];(2)FT1DM组空腹胰高糖素水平低于健康对照组[(6.19±2.92)比(7.60±0.90)pmol/L],高于经典T1DM组[(4.33±0.69)pmol/L]。SBMT后FT1DM组及经典T1DM组各时间点胰高糖素水平均较基线值升高。各组iAUC glucagon比较,差异有统计学意义(FANOVA=34.344,P<0.001)。FT1DM组iAUC glucagon高于经典T1DM组[(21.55±8.88)比(6.72±2.92)pmol·L^-1·h^-1,t=2.987,P=0.006]及健康对照组[(-13.16±7.68)pmol·L^-1·h^-1,t=7.348,P<0.001]。结论新发FT1DM患者在起病时不仅存在胰岛β细胞功能的完全衰竭,还伴随着胰岛α细胞功能的障碍,主要表现为餐后高胰高糖素血症。 展开更多
关键词 糖尿病 1型 暴发性1型糖尿病 α细胞功能 胰高糖素
Evaluation of Pregnancy Outcomes among Women with Pregnancies Complicated by Diabetes Mellitus in Abakaliki, South-East, Nigeria 预览
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作者 Nwafor Johnbosco Ifunanya Onwe Blessing Idzuinya +4 位作者 Obi Vitus Okwuchukwu Ugoji Darlington-Peter Chibuzor Ibo Chukwunenye Chukwu Obi Chuka Nobert Onuchukwu Victor Jude Uchenna 《糖尿病(英文)》 2019年第3期69-76,共8页
Background: Pregnancies complicated by diabetes are associated with significant increase in maternal and perinatal morbidity and mortality. The management of diabetes in pregnancy is a great challenge in a low resourc... Background: Pregnancies complicated by diabetes are associated with significant increase in maternal and perinatal morbidity and mortality. The management of diabetes in pregnancy is a great challenge in a low resource setting because of limited resources and facilities to care for these women. Aim: To determine the maternal and perinatal outcomes of diabetic pregnant women managed at Alex Ekwueme Federal University Teaching Hospital Abakaliki, Southeast, Nigeria. Materials and methods: This was a 7-year retrospective case-control study that compared pregnancy outcomes among women with pregnancies complicated by diabetes and those without diabetes managed at Alex Ekwueme Federal University Teaching Hospital, Abakalikibetween January 1st, 2012 and December 31st, 2018. The statistical analysis was done using SPSS version 22. Results: The incidence of diabetes in pregnancy in this study was 6.6 per 1000 deliveries. Of 126 women in diabetic arm of the study, 81 were diagnosed during pregnancy and 45 were known diabetic prior to conception. Over two-thirds of 126 women with pregnancy complicated by diabetes achieved good blood glucose control during pregnancy. Both groups differ in their mean BMI and women with diabetes in pregnancy were more likely to be obese compared with control (diabetic;30.1 ± 2.5 versus control;23.4 ± 2.1, P < 0.0001). Pregnant women with diabetes were more likely to be delivered by cesarean section when compared with non-diabetic women (86 versus 23, OR = 9.6, 95% CI: 5.35 - 17.32, P < 0.0001). Similarly, the incidence of polyhydramnious was higher in paturients with diabetes when compared with the control groups (26 versus 13, OR = 2.2, 95%CI: 1.10 - 4.63, P = 0.02). There were no differences between both study groups with regards to other maternal outcomes. The incidence of fetal macrosomia, neonatal hypoglycemia and neonatal respiratory distress syndrome were significantly higher among women whose pregnancies were complicated by diabetes when compared with the control [Diabetics;fetal mac 展开更多
关键词 PREGNANCIES COMPLICATED Diabetes MELLITUS MATERNAL PERINATAL Abakaliki
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Complementary and Alternative Medicine: A Review on the Effects of Ginger, Cinnamon and Camellia Sinensis Leaf Tea in Diabetes 预览
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作者 Massud Atta Shadi Jafari Kareen Moore 《糖尿病(英文)》 2019年第3期126-136,共11页
Diabetes mellitus is a chronic disease with a multitude of effects on different organ-systems. Its chronic nature makes it a challenging disease for patients to manage. Today, patients have access to many different ty... Diabetes mellitus is a chronic disease with a multitude of effects on different organ-systems. Its chronic nature makes it a challenging disease for patients to manage. Today, patients have access to many different types of conventional therapies for diabetes, each with a different mode of action and side effects. Despite the wide range of therapeutic agents available today, patients seek help from complementary and alternative medicine. The decision to use complementary and alternative medicine by patients stems from some of the harmful side effects of current conventional therapies, as well as their desire to find measures that will help them to manage their disease. Complementary and alternative medicine includes several modalities ranging from dietary components such as vitamins and herbal supplements to mind-body interventions such as yoga, meditation, and massage therapy. Here we review the use of complementary and alternative medicine including Ginger, Cinnamon, and Camellia sinensis leaf tea, and their effects on glycemic indices in diabetes. 展开更多
关键词 DIABETES Mellitus Complementary and Alternative Medicine Insulin Hemoglobin A1c Fasting Blood Glucose GINGER CINNAMON Camellia Sinensis ZINGIBER officinale CINNAMOMUM zeylanicum Ceylon CINNAMON CINNAMON CASSIA
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糖尿病酮症或酮症酸中毒起病的成人新诊断糖尿病患者临床特征及分型诊断
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作者 刘宏霞 李贵梅 +7 位作者 周泳雯 骆斯慧 郑雪瑛 杨黛稚 梁华 严晋华 姚斌 翁建平 《中华医学杂志》 CAS CSCD 北大核心 2019年第18期1369-1374,共6页
目的探讨以糖尿病酮症(DK)或糖尿病酮症酸中毒(DKA)起病的成人新诊断糖尿病患者的临床特征,为其分型诊断提供依据。方法回顾性分析中山大学附属第三医院2011年1月1日至2016年8月31日期间住院患者资料,入选DA或DKA起病、诊断年龄≥18岁... 目的探讨以糖尿病酮症(DK)或糖尿病酮症酸中毒(DKA)起病的成人新诊断糖尿病患者的临床特征,为其分型诊断提供依据。方法回顾性分析中山大学附属第三医院2011年1月1日至2016年8月31日期间住院患者资料,入选DA或DKA起病、诊断年龄≥18岁的新诊断糖尿病患者。分析出院诊断为1型糖尿病(T1DM)、2型糖尿病(T2DM)、糖尿病未分型三组患者的临床特征。通过住院和门诊病案系统追踪患者出院2年内的用药情况和最终诊断,利用受试者工作特征曲线(ROC)评价起病年龄、体质指数(BMI)和C肽等临床指标对T1DM和T2DM的诊断价值及最佳诊断切点。结果共123例(男88例)患者纳入分析,年龄(41.1±13.6)岁。出院诊断为T1DM、T2DM和未分型的例数分别为37(30.1%)、60(48.8%)和26例(21.1%),三组患者在起病年龄,BMI,血压,血气pH值及碳酸氢根,血脂,空腹、0.5h及2h C肽水平,任一糖尿病自身抗体及谷氨酸脱羧酶抗体(GADA)阳性率,合并脂肪肝比例和糖尿病家族史比例差异均有统计学意义(均P<0.05)。对2年随访后确诊为T1DM(36例)和T2DM(87例)的患者行ROC曲线分析,结果显示起病年龄、BMI、空腹C肽、0.5h C肽及2h C肽作为诊断指标时的曲线下面积(AUC)分别为0.735、0.813、0.855、0.898、0.882。结论C肽、起病年龄和BMI等临床特点对DK或DKA起病的成人新诊断患者具有较好的分型诊断价值,且C肽的诊断价值优于BMI和年龄。 展开更多
关键词 糖尿病 1型 糖尿病 2型 糖尿病酮症酸中毒
Betatrophin与糖尿病及其并发症的相关性研究进展 预览
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作者 李晓佩 韩晓 金勇君 《医学综述》 2019年第3期535-539,544共6页
糖尿病的患病率逐年增加,已成为危害人类健康的重要慢性病之一,其并发症可严重降低人们的生活质量,甚至危害生命。目前,对糖尿病及其并发症的研究日益增多。现已发现由肝脏产生的一种新的分泌性蛋白--Betatrophin,它属于血管紧张素样蛋... 糖尿病的患病率逐年增加,已成为危害人类健康的重要慢性病之一,其并发症可严重降低人们的生活质量,甚至危害生命。目前,对糖尿病及其并发症的研究日益增多。现已发现由肝脏产生的一种新的分泌性蛋白--Betatrophin,它属于血管紧张素样蛋白家族中成员之一,能够参与糖脂代谢,与糖尿病及其并发症的关系密切,可为糖尿病及其并发症的诊治提供新靶点。但目前Betatrophin与糖尿病之间的相关机制仍不明确,进一步研究糖尿病的诊治进展具有重要意义。 展开更多
关键词 糖尿病 Betatrophin 糖尿病慢性并发症
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Fibroscan of Liver in Type 2 Diabetes Mellitus and Its Correlation with Risk Factors 预览
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作者 Nikhil A. Kumar Sidhartha Das 《糖尿病(英文)》 2019年第2期62-68,共7页
Introduction: Non-alcoholic fatty liver disease (NAFLD) is regarded as the hepatic manifestation of metabolic syndrome. Insulin resistance is regarded as central to the development of NAFLD. Type 2 Diabetes Mellitus (... Introduction: Non-alcoholic fatty liver disease (NAFLD) is regarded as the hepatic manifestation of metabolic syndrome. Insulin resistance is regarded as central to the development of NAFLD. Type 2 Diabetes Mellitus (DM) is an important cause of NAFLD. The pathology in NAFLD ranges from hepatic steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis and primary liver cancer. Diagnosis of NAFLD requires demonstration of increased liver fat in the absence of hazardous levels of alcohol consumption. Liver biopsy is the gold standard for diagnosis of NAFLD but it is fraught with various difficulties and is a risky procedure. Fibroscan (?Abbott) or transient elastography is a non-invasive tool which measures the hepatic stiffness. Objective: To estimate the degree of hepatic stiffness due to NAFLD and to identify the factors affecting it. Patients: 50 patients of newly diagnosed Type 2 diabetes mellitus without a history of chronic hepatitis or alcohol intake were included in the study. Results: In our study, 40% of the patients were obese with 46% of the total patients having an elevated AST, 66% having an elevated ALT and 18% having an elevated alkaline phosphatase. Dyslipidemia was very common with 14% of total patients having a high cholesterol, 36% having elevated triglycerides, 64% having a low HDL with none with an elevated LDL. 50% of patients had steatosis on ultrasound. On comparing liver stiffness, a significantly high hepatic stiffness (>7.9 kPa) was found in 34% of patients with severe fibrosis (≥12 kPa) in 10% of patients. Multivariate analysis showed significant positive correlation of fibroscan value with total cholesterol and ALT levels and there was a significant negative correlation with AST levels and serum HDL levels. Conclusion: Fibroscan may be helpful in diagnosing and guiding treatment of NAFLD. Larger studies to evaluate its efficacy in determining prognosis of NAFLD are warranted. 展开更多
关键词 Diabetes MELLITUS NAFLD FIBROSCAN Transient ELASTOGRAPHY NASH
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Insulin Requirements and Management in Trans-Catheter vs. Surgical Aortic Valve Replacement 预览
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作者 Yunyan Qu Liyu Xing +2 位作者 Nazanene H. Esfandiari George M. Deeb Roma Gianchandani 《胸外科期刊(英文)》 2019年第3期17-30,共14页
Objective: Trans-catheter Aortic Valve Replacement/Aortic Valve Implantation (TAVR) are increasingly performed today. We compared insulin requirements between TAVR and Surgical Aortic Valve Replacement (SAVR) patients... Objective: Trans-catheter Aortic Valve Replacement/Aortic Valve Implantation (TAVR) are increasingly performed today. We compared insulin requirements between TAVR and Surgical Aortic Valve Replacement (SAVR) patients with and without diabetes mellitus (DM) to determine optimal glucose management strategies during the perioperative period (POP). Methods: Charts of consecutive patients undergoing aortic procedures were retrospectively reviewed for glucose ranges, insulin requirements and routes of insulin administration (subcutaneous vs. intravenous) for patients with and without DM to maintain BG Results: Patients with SAVRs without DM and A1C Conclusions: TAVR patients have different insulin requirements compared to SAVRs (p < 0.05). This information helps build a glucose management algorithm for a procedure which is increasingly performed. 展开更多
关键词 AORTIC Stenosis Diabetes Mellitus Trans-Catheter AORTIC VALVE REPLACEMENT SURGICAL AORTIC VALVE REPLACEMENT Blood Glucose MANAGEMENT
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分型不明的婴幼儿糖尿病病因学探讨 预览
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作者 沈凌花 卫海燕 +7 位作者 张英娴 陈琼 刘芳 刘晓景 杨海花 崔岩 陈永兴 杨威 《临床儿科杂志》 CAS CSCD 北大核心 2019年第8期594-597,共4页
目的探讨分型不明的婴幼儿糖尿病的病因。方法回顾分析2013年-2016年收治,3岁内起病的自身抗体阴性胰岛素依赖1型糖尿病(T1DM)患儿的临床资料。结果共收集19例患儿,男12例、女7例,起病年龄8个月~3岁;主要症状为乏力、消瘦、多饮、多尿;... 目的探讨分型不明的婴幼儿糖尿病的病因。方法回顾分析2013年-2016年收治,3岁内起病的自身抗体阴性胰岛素依赖1型糖尿病(T1DM)患儿的临床资料。结果共收集19例患儿,男12例、女7例,起病年龄8个月~3岁;主要症状为乏力、消瘦、多饮、多尿;糖化血红蛋白8.6%~12%,合并酮症酸中毒14例;19例患儿的胰岛细胞抗体(ICA)、谷氨酸脱羧酶抗体(GAD65-Ab)、胰岛素抗体(IAA)均为阴性,胰岛素水平正常偏低。采用二代测序及甲基化MLPA方法检测28个糖尿病相关基因,2例患儿阳性;其中1例携带HNF1Ac.1699G>A,为已报道的杂合突变,来自其血糖正常的母亲;另1例携带CEL基因的c.2214delT,为尚未见报道的杂合突变,来自其空腹血糖正常的父亲。结论自身抗体阴性T1DM与单基因糖尿病之间存在交叉与重叠,二代测序对早期明确诊断有重要意义。 展开更多
关键词 糖尿病 婴幼儿 基因突变 单基因糖尿病
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Uric Acid and GGT Have Causal Relations with Abdominal Obesity: A Real-Life Research in Turkish Population with 1214 Diabetics 预览
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作者 Deniz Avci Ali ?etinkaya 《生物科学与医学(英文)》 2019年第2期1-14,共14页
Aim: We compared the waist circumferences (WC) of 1214 diabetics with various parameters in real-life conditions. Patients and Method: The study was carried out by reviewing the anthropometric measurements and biochem... Aim: We compared the waist circumferences (WC) of 1214 diabetics with various parameters in real-life conditions. Patients and Method: The study was carried out by reviewing the anthropometric measurements and biochemical analyzes of diabetics and they were analyzed due to WC status of the patients. Results: Mean total cholesterol level was 204.6 ± 47.1 mg/dL in patients with normal WC and 211.6 ± 45.6 mg/dL in patients with increased WC (p = 0.015). Total cholesterol was found to be a risk factor for WC enlargement (OR: 1.003, 95% CI: 1.001 - 1.006, p = 0.015). HDL-cholesterol appeared to be a risk factor for the increase in WC (OR: 1.005, CI: 1.001 - 1.010, p = 0.029). Median triglyceride level was 158 (41 - 975) mg/dL in the normal WC group, while it was 176 (22 - 1379) mg/dL in the patients with increased WC (p Conclusion: We have demonstrated that the measurement of WC has an important role in diabetes management and is related with inflammatory parameters such as uric acid and GGT. 展开更多
关键词 Diabetes Mellitus WAIST CIRCUMFERENCE Uric Acid GGT Inflammation
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Dipeptidyl Peptidase-4 Inhibitors and Inflammation: Dpp-4 Inhibitors Improve Mean Pleatelet Volume and Gamma Glutamyl Transferase Level 预览
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作者 Deniz Avc? 《生物科学与医学(英文)》 2019年第2期42-53,共12页
AIM: The purpose of this research was to determine the changes of the inflammatory parameters in the long term with the use of dipeptidyl peptidase-4 inhibitors. Material and Methods: In this research we have retrospe... AIM: The purpose of this research was to determine the changes of the inflammatory parameters in the long term with the use of dipeptidyl peptidase-4 inhibitors. Material and Methods: In this research we have retrospectively reviewed the records of 80 patients who had added dipeptidyl peptidase-4 inhibitors (40 sitagliptin and 40 vildagliptin) to their ongoing therapies. Patients’ values of inflammation at the beginning of this process were taken as initial values, while values at the end of this process were considered as final values. Results: A total of 80 patients [38.8% (n = 31) of the patients were male, while 61.3% (n = 49) were female] enrolled in the study. When the whole group was evaluated, the mean age was 56.1 ± 9.7 years. The median follow-up time of the patients with DPP-4 inhibitors was 18 (2 - 64) months. The mean MPV value was measured as 8.79 ± 1.71 fL before DPP-4 inhibitors and it was 10.06 ± 1.42 fL after the follow-up period (p < 0.001). The median value serum GGT was 30.5 (13 - 194) U/L before DPP-4 inhibitor and 29.5 (12 - 112) U/L at the end (p = 0.048). The mean uric acid level before the use of di-peptidyl peptidase-4 inhibitors was 4.7 ± 1.6 mg/dL, and this level was 5.0 ± 1.5 mg/dL after the follow-up period (p = 0.048). Conclusion: In this study, it was observed that MPV and GGT levels were improved by dipeptidyl peptidase-4 inhibitors in long-term. 展开更多
关键词 DPP-4 INHIBITORS MPV GGT INFLAMMATION Diabetes MELLITUS
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Modulations in Anti-Oxidant Activities of Selected Gastro-Intestinal Tissues in Alloxan-Induced, Silymarin Treated Diabetic Wistar Rats 预览
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作者 Johnson Uyovwiesevwa Ataihire Eze Kingsley Nwangwa John Chukwuka Igweh 《肠胃病学期刊(英文)》 2019年第5期73-90,共18页
Diabetes mellitus (DM) is reportedly the commonest metabolic disorder with multi organ involvement. By inducing DM (with Alloxan) in Wistar rats, current study investigated the changes in antioxidant activities of sel... Diabetes mellitus (DM) is reportedly the commonest metabolic disorder with multi organ involvement. By inducing DM (with Alloxan) in Wistar rats, current study investigated the changes in antioxidant activities of selected gastrointestinal (GI) tissues [stomach, duodenum, pancreas and liver], upon treatment with Silymarin and/or Vitamin C. One hundred and twenty five (125) adult male wistar rats of between 130 to 180 grams were procured for the study. Five units of one control and four experimental units were designated with twenty five (25) rats per group (n = 25);Unit 1: Control rats, Unit 2 were DM induced, Silymarin untreated rats, and Units 3, 4 and 5 were DM induced, vitamin C, Silymarin and Vitamin C + Silymarin treated respectively. Following four (4) weeks of administration of test substance(s), rats were euthanized and blood samples obtained for biochemical and antioxidant assay on aforementioned GI tissues. One way analysis of variance (ANOVA) and Students t-test at p p < 0.05) at comparison of extract treated unit to control. Study also observed a significant change in pancreatic, liver, and duodenal anti-oxidant marker levels with Vitamin C, Silymarin and Vitamin C + Silymarin co-administrations to diabetic rats. It can therefore be said, that DM caused a destructive alteration pancreatic histo-architecture with improved functional capabilities in wistar rats at administration of Silymarin and vitamin C. Thus, Silymarin posed antioxidant potentials, with ameliorated pancreatic dysfunctions. 展开更多
关键词 SILYMARIN Antioxidant Diabetes MELLITUS
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儿童糖尿病基因检测研究进展
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作者 王晓艳 陈临琪 +1 位作者 孙辉 吴海瑛 《中国实用儿科杂志》 CSCD 北大核心 2019年第6期523-526,共4页
儿童糖尿病是一组以高血糖为特征,可引起多器官系统并发症的疾病。主要包括1型糖尿病(T1DM)、2型糖尿病(T2DM)和其他类型糖尿病。近年来,随着二代基因测序技术的发展,儿童糖尿病的研究也取得了一些进步。本文就儿童糖尿病与基因的相关... 儿童糖尿病是一组以高血糖为特征,可引起多器官系统并发症的疾病。主要包括1型糖尿病(T1DM)、2型糖尿病(T2DM)和其他类型糖尿病。近年来,随着二代基因测序技术的发展,儿童糖尿病的研究也取得了一些进步。本文就儿童糖尿病与基因的相关内容加以综述。 展开更多
关键词 基因检测 糖尿病 单基因糖尿病
糖尿病患者25羟维生素D3水平与血脂、胰岛素功能的相关性 预览
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作者 艾扎提古丽·卡的尔 帕它木·莫合买提 《中国现代医学杂志》 CAS 2019年第16期54-57,共4页
目的分析糖尿病患者25羟维生素D3[25-(OH)D3]水平与血脂、胰岛素功能的关系。方法选取2018年6月—2018年12月在新疆医科大学第一附属医院住院治疗的1型糖尿病(T1DM)、2型糖尿病(T2DM)患者,每组78例。另选取同期78例健康体检者作为对照... 目的分析糖尿病患者25羟维生素D3[25-(OH)D3]水平与血脂、胰岛素功能的关系。方法选取2018年6月—2018年12月在新疆医科大学第一附属医院住院治疗的1型糖尿病(T1DM)、2型糖尿病(T2DM)患者,每组78例。另选取同期78例健康体检者作为对照组。根据[25-(OH)D3]水平不同分为维生素D3(VD3)<50nmol/L组(69例)和VD3≥50nmol/L组(165例),比较两组患者血脂、胰岛素功能及其相关性。结果①3组年龄、体重指数(BMI)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2h血糖、空腹血清C肽、餐后2h血清C肽、25-(OH)D3及胰岛β细胞功能指数水平比较,差异有统计学意义(P<0.05);②VD3<50nmol/L组总胆固醇(TC)含量低于VD3≥50nmol/L组,而胰岛β细胞功能指数高于VD3≥50nmol/L组(P<0.05);③相关性分析结果显示,T1DM组患者VD3水平、BMI与胰岛β细胞指数呈负相关(r=-0.259和-0.491,P=0.025和0.043);T2DM组患者VD3水平与TC含量呈负相关(r=-0.227,P=0.046);结论糖尿病患者VD3水平与TC及胰岛素β细胞功能密切相关。 展开更多
关键词 糖尿病 1型 糖尿病 2型 胰岛素 血脂异常
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葛根芩连汤对糖尿病前期预防研究
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作者 曾国威 盛译萱 +3 位作者 李冰涛 张启云 姜丽 徐国良 《中药新药与临床药理》 CAS CSCD 北大核心 2019年第12期1449-1453,共5页
目的观察葛根芩连汤(GQD)干预对肥胖型2型糖尿病(T2DM)前期胰岛素抵抗(IR)模型大鼠血脂血糖的影响,探究GQD对肥胖型T2DM前期的预防作用。方法60%脂肪供能高脂饲料喂养SD雄性大鼠复制胰岛素抵抗(IR)模型,模型复制成功后继续使用高脂饲料... 目的观察葛根芩连汤(GQD)干预对肥胖型2型糖尿病(T2DM)前期胰岛素抵抗(IR)模型大鼠血脂血糖的影响,探究GQD对肥胖型T2DM前期的预防作用。方法60%脂肪供能高脂饲料喂养SD雄性大鼠复制胰岛素抵抗(IR)模型,模型复制成功后继续使用高脂饲料喂养至肥胖型T2DM前期,同时灌胃给予GQD干预16周。眼后静脉丛取血检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)及空腹胰岛素(FINS),计算IR指数。结果GQD低、中、高剂量均显著降低肥胖型T2DM前期大鼠体质量(P<0.05,P<0.01,P<0.05);GQD中、高剂量显著降低TC(P<0.01)及LDLC(P<0.01),GQD高剂量同时显著降低HDL-C(P<0.01);GQD低、中剂量显著降低IR指数(P<0.05),GQD低剂量同时显著降低FPG(P<0.05)。结论GQD可有效控制高脂饲料导致的体质量增长并延缓肥胖型T2DM前期病程发展。 展开更多
关键词 肥胖 糖尿病 肥胖型2型糖尿病 胰岛素抵抗 葛根芩连汤
Ozone Therapy in a Patient with Diabetic Foot Ulcerations and a Decision for Amputation 预览
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作者 Saltuk Aytacoglu Barlas Naim Aytacoglu 《临床医学病理报告(英文)》 2019年第2期35-41,共7页
Background: Diabetic foot together with open wounds in distal type peripheral arterial disease constitutes a challenge in therapeutic planning. Ozone therapy may unveil new horizons in management. Case Report: A 67-ye... Background: Diabetic foot together with open wounds in distal type peripheral arterial disease constitutes a challenge in therapeutic planning. Ozone therapy may unveil new horizons in management. Case Report: A 67-year-old woman with diabetes mellitus was applied with open wounds at the bottom of her foot with purulent discharge, with a decision for above ankle amputation. She had had numerous interventions for her wounds including metatarsal amputations due to osteomyelitis and had been on an intense treatment including antibiotics, insulin, antihypertensives and antiaggregants. Angiogram revealed diffuse peripheral arterial disease in lower extremities. All medication but antihypertensives was stopped. She received major medical ozone application as 2000 gamma/session i.v. for 2 weeks, external ozone sac application starting from 60 and dropping to 30 gamma/session for 3 weeks and ozone insuflation 40 gamma/session for 10 sessions. Her purulent discharge ceased after the third session and the atonic debris of the wounds exfoliated, the wounds healed from the base towards the surface of the skin. She was then put on cilostazol and clopidogrel therapy. Conclusion: By being one of the known strongest bactericide, virucide, and fungicide elements, medical ozone therapy stimulates and upregulates the antioxidant system of the body with its hormesis effects. After the cessation of all circulatory system supporting medication (as their interaction with ozone is not clear yet), appropriate ozone therapy may bring new horizons for patients when all classically known methods of treatment have been completed, before assigning the patients for amputation. 展开更多
关键词 DIABETIC Foot ULCERATION Medical OZONE Treatment Diabetes MELLITUS EXTREMITY AMPUTATION
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