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河南省新型冠状病毒肺炎中医辨证治疗思路与方法 预览
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作者 李建生 李素云 谢洋 《中医学报》 CAS 2020年第3期453-457,共5页
根据我省新型冠状病毒肺炎临床调查资料,结合临床救治实践经验,从病因病机、辨证与治法、分期辨证治疗三个方面,阐释河南省新型冠状病毒肺炎的中医辨证治疗思路与方法。一是病因病机:病邪属性为湿邪、湿邪疫毒首先犯肺,并随疾病的分期/... 根据我省新型冠状病毒肺炎临床调查资料,结合临床救治实践经验,从病因病机、辨证与治法、分期辨证治疗三个方面,阐释河南省新型冠状病毒肺炎的中医辨证治疗思路与方法。一是病因病机:病邪属性为湿邪、湿邪疫毒首先犯肺,并随疾病的分期/分型发生转化。二是辨证与治法:根据疾病的轻重分型,提出了4期9证(初期的湿遏肺卫、寒湿犯肺、邪热犯肺,进展期的湿阻肺胃、湿热蕴肺、疫毒闭肺,危重期的内闭外脱,恢复期的气阴两虚、肺脾气虚)的证候规律,重点强调截断扭转、逐秽解毒、疏理气机、通降胃肠、固扶正气5种治则治法。三是分期辨证治疗:根据4期9证进行辨证治疗,分析了常用方药、中成药等,为新型冠状病毒肺炎的中医辨证治疗提供参考。 展开更多
关键词 新型冠状病毒 新型冠状病毒肺炎 证候 辨证论治
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数据挖掘技术在中医辨证施治中的应用 预览
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作者 张连堂 吴广裕 《教育教学论坛》 2020年第3期249-252,共4页
数据挖掘技术中的支持向量机是一种基于结构风险最小化的分类算法.文章通过分析该算法的机理和应用特征,结合中医脏腑辨证理论,通过对大量中医脏腑辨证施治实例的研究,探索出用该算法解决一直困扰传统中医“脏腑辨证”分析过程中的诸多... 数据挖掘技术中的支持向量机是一种基于结构风险最小化的分类算法.文章通过分析该算法的机理和应用特征,结合中医脏腑辨证理论,通过对大量中医脏腑辨证施治实例的研究,探索出用该算法解决一直困扰传统中医“脏腑辨证”分析过程中的诸多不确定性问题的方法,具有良好的实用价值. 展开更多
关键词 数据挖掘 支持向量机 证候 辨证
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Relationship between metabolic syndrome and hypercapnia among obese patients with sleep apnea 预览
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作者 Yuka Kimura Takatoshi Kasai +5 位作者 Yasuhiro Tomita Satoshi Kasagi Hisashi Takaya Mitsue Kato Fusae Kawana Koji Narui 《世界呼吸病学杂志》 2020年第1期1-10,共10页
BACKGROUND In the obese patient population,some patients have severe obstructive sleep apnea(OSA)with daytime hypoventilation.Such patients are generally identified on the basis of the presence or absence of daytime h... BACKGROUND In the obese patient population,some patients have severe obstructive sleep apnea(OSA)with daytime hypoventilation.Such patients are generally identified on the basis of the presence or absence of daytime hypercapnia,and the condition is called obesity hypoventilation syndrome.However,mechanisms for such daytime hypoventilation remain unclear.AIM To investigate metabolic syndrome and daytime hypercapnia association based on hypercapnia prevalence in obese OSA patients in a nested case-control study.METHODS Consecutive obese patients(body mass index≥30 kg/m2)who underwent polysomnography due to suspected OSA were included.Among them,patients with severe OSA(apnea hypopnea index≥30/h)were divided into two groups according to the presence or absence of hypercapnia during wakefulness(arterial partial pressure of carbon dioxide≥or<45 Torr,respectively).The characteristics and clinical features of these two groups were compared.RESULTS Among 97 eligible patients,25 patients(25.8%)had daytime hypercapnia.There were no significant differences in age,gender,body mass index,apnea-hypopnea index,and Epworth Sleepiness Scale scores between the two groups.However,patients with hypercapnia had a significantly lower arterial partial pressure of oxygen level(75.8±8.2 torr vs 79.9±8.7 torr,P=0.042)and higher arterial partial pressure of carbon dioxide level(46.6±2.5 torr vs 41.0±2.9 torr,P<0.001).Additionally,patients with hypercapnia were more likely to have metabolic syndrome(72.0%vs 48.6%,P=0.043)and a higher metabolic score(the number of satisfied criteria of metabolic syndrome).In multivariate logistic regression analysis,the presence of metabolic syndrome was associated with the presence of hypercapnia(OR=2.85,95%CI:1.04-7.84,P=0.042).CONCLUSION Among obese patients with severe OSA,26%of patients had hypercapnia during wakefulness.The presence of metabolic syndrome was independently correlated with the presence of daytime hypercapnia. 展开更多
关键词 Arterial partial pressure of carbon dioxide HYPERCAPNIA Metabolic SYNDROME Obesity HYPOVENTILATION SYNDROME Obstructive SLEEP APNEA SLEEP DISORDERED breathing
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Traditional Chinese medicine combined with low-dose glucocorticoid for treating nephrotic syndrome: A case report 预览
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作者 Shu-Ting Huang Si-Chao Ding Gan-Feng Xu 《药物联合治疗》 2020年第1期34-44,共11页
Nephrotic syndrome(NS)is a common refractory clinical disease that can develop into end-stage renal disease(ESRD)if cannot be controlled.At present,in Western medicine,glucocorticoid or immunosuppressant drugs with he... Nephrotic syndrome(NS)is a common refractory clinical disease that can develop into end-stage renal disease(ESRD)if cannot be controlled.At present,in Western medicine,glucocorticoid or immunosuppressant drugs with heavy dose and long course are used for the therapy of NS.There are still few reports on the combined treatment of traditional Chinese medicine and low-dose glucocorticoid for NS.Here,we reported a case of a 48-year-old man diagnosed with NS,accompanied by severe pulmonary infection,abundant proteinuria,and pleural effusion.Integrated traditional Chinese and Western medicine was used as the therapeutic regimen of this patient.Traditional Chinese medicine(TCM)mainly focused on invigorating spleen and kidney,promoting blood circulation,removing blood stasis and promoting diuresis,and Chinese patent medicines or TCM immunosuppressants were given to consolidate the treatment.In Western medicine,small dose and short course glucocorticoids combined with symptomatic treatment were adopted.Delightfully,proteinuria subsided after 5 months treatment with integrated TCM and Western medicine and all laboratory reports were negative after 10 months,which has been normal so far(July 2019).This case report indicates that the combination of TCM and low-dose glucocorticoid is effective in curing NS,with low recurrence rate and few side effects. 展开更多
关键词 Nephrotic SYNDROME Traditional CHINESE MEDICINE Integrated CHINESE and Western MEDICINE Treatment based on SYNDROME differentiation GLUCOCORTICOID
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Fear can be more harmful than the severe acute respiratory syndrome coronavirus 2 in controlling the corona virus disease 2019 epidemic 预览
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作者 Shi-Yan Ren Rong-Ding Gao Ye-Lin Chen 《世界临床病例杂志》 2020年第4期652-657,共6页
The current corona virus disease 2019 outbreak caused by severe acute respiratory syndrome coronavirus 2 started in Wuhan,China in December 2019 and has put the world on alert.To safeguard Chinese citizens and to stre... The current corona virus disease 2019 outbreak caused by severe acute respiratory syndrome coronavirus 2 started in Wuhan,China in December 2019 and has put the world on alert.To safeguard Chinese citizens and to strengthen global health security,China has made great efforts to control the epidemic.Many in the global community have joined China to limit the epidemic.However,discrimination and prejudice driven by fear or misinformation have been flowing globally,superseding evidence and jeopardizing the anti-severe acute respiratory syndrome coronavirus 2 efforts.We analyze this phenomenon and its underlying causes and suggest practical solutions. 展开更多
关键词 CORONAVIRUS Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 OUTBREAK FEAR Discrimination PREJUDICE
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Study on the Biological Basis of Qi, Blood, and Vessel in Immune Thrombocytopenia Patients With Syndrome of Qi Failing to Govern Blood Based on the Theory of Qi and Blood 预览
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作者 王明镜 陈卓 +7 位作者 朱世荣 丁晓庆 谌海燕 全日城 许勇钢 赵攀 姜云耀 胡晓梅 《世界中西医结合杂志(英文)》 2020年第1期18-25,共8页
Objective: To investigate the biological basis of qi, blood and vessel in immune thrombocytopenia(ITP) patients with syndrome of qi failing to govern blood(SQFGB) based on traditional Chinese medicine.Methods: A total... Objective: To investigate the biological basis of qi, blood and vessel in immune thrombocytopenia(ITP) patients with syndrome of qi failing to govern blood(SQFGB) based on traditional Chinese medicine.Methods: A total of 52 ITP patients with SQFCB were enrolled and divided into bleeding group(38 cases) and non-bleeding group(14 cases).Bleeding group was further divided into mild qi deficiency group(25 cases) and moderate/severe qi deficiency group(13 cases) based on Chinese Medicine syndrome score.20 healthy volunteer were recruited as control group.The count of platelet(PLT) was taken as the blood related indicator.The expressions of cytokines including IL-1β, IL-17 A, TNF-α, CD40 L, and TGF-β, detected by Aim Plex Multiple Immunoassays for Flow, were taken as the qi related indicators.The expressions of VEGF-A, detected by Aim Plex Multiple Immunoassays for Flow and NO, NOS, and ET-1 detected by ELISA, were taken as the vessel related indicators.Results: As compared to the control group, the count of PLT, taken as the blood related indicator, was significantly lower in ITP group patients with SQFCB(P<0.05).The expression levels of IL-17 A and TNF-α, taken as the qi related indicators, were significantly higher, while those of CD40 L, IL-1β, and TGF-β, also taken as the qi related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The expression levels of NO and ET-1, taken as the vessel related indicators, were significantly higher, while the expression levels of NOS and VEGF-A also taken as the vessel related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The count of PLT, taken as the blood related indicator, was significantly lower in moderate/severe group than those in mild group(P<0.05).The expression levels of CD40 L and TGF-β, taken as the qi related indicators, were also significantly lower in moderate/severe group than those in mild group, respectively(P<0.05).Conclusion: The count of PLT might be the biological basis of b 展开更多
关键词 Syndrome of QI failing to govern BLOOD IMMUNE THROMBOCYTOPENIA Theory of QI and BLOOD Chinese MEDICINE
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Improvement and Application of Acute Blood Stasis Rat Model Aligned with the 3Rs (Reduction, Refinement and Replacement) of Humane Animal Experimentation
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作者 HUANG Shuai XU Feng +4 位作者 WANG Yin-ye SHANG Ming-ying WANG Chao-qun WANG Xuan CAI Shao-qing 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2020年第4期292-298,共7页
Objective:To establish a novel cardiocentesis method for withdrawing venous blood from the right atrium,and to improve an acute blood stasis rat model using an ice bath and epinephrine hydrochloride(Epi)while consider... Objective:To establish a novel cardiocentesis method for withdrawing venous blood from the right atrium,and to improve an acute blood stasis rat model using an ice bath and epinephrine hydrochloride(Epi)while considering the 3Rs(reduction,refinement,and replacement)of humane animal experimentation.Methods:An acute blood stasis model was established in male Sprague-Dawley rats by subcutaneous injection(s.c.)Epi(1.2mg/kg)administration at 0h,followed by a 5-min exposure to an ice-bath at 2h and s.c.Epi administration at 4h.Control rats received physiological saline.Rats were fasted overnight and treated with Angelicae Sinensis Lateralis Radix(ASLR)and Pheretima the following day.Venous blood was collected using our novel cardiocentesis method and used to test whole blood viscosity(WBV),prothrombin time(PT),activated partial thromboplastin time(APTT),and fibrinogen(FIB)8ntent.Results:The rats survived the novel cardiocentesis technique;WBV value returned to normal while hematological parameters such as hemoglobin level and red blood cell count were restored to>94%of the corresponding values in normal rats following a 14-day recovery.Epi(1.2 mg/kg,s.c.)combined with a 5-min exposure to the ice bath replicated the acute blood stasis rat model and was associated with the highest WBV value.In rats showing acute blood stasis,ASLR treatment[4g/(kg-d)for 8 days]decreased WBV by 9.98%,11.09%,9.34%,9.00%,7.66%,and 7.03%(P<0.05),while Pheretima treatment[2.6g/(kg・d),for 8 days]decreased WBV by 25.49%,25.94%,16.28%,17.76%,11.07%,and 7.89%(P<0.01)at shear rates of 1,3,10,30,100,and 180 s'1,respectively.Furthermore,Pheretima treatment increased APTT significantly(P<0.01).Conclusions:We presented a stable,reproducible,and improved acute blood stasis rat model,which could be applied to screen drugs for promoting blood circulation and eliminating blood stasis. 展开更多
关键词 acute blood stasis rat model cardiocentesis whole blood viscosity coagulation parameters Angelicae Sinensis Lateralis Radix PHERETIMA Chinese medicine syndrome
PRPS1基因及其突变与相关临床综合征的研究进展
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作者 杨怡 李彦欣 《国际输血及血液学杂志》 CAS 2020年第1期82-88,共7页
PRPS1基因编码的磷酸核糖焦磷酸合成酶(PRS)1是参与核酸合成的第一限速酶,其对细胞功能,特别是嘌呤、嘧啶相关的合成、代谢等有重要影响。当PRPS1基因突变引起PRS1晶体结构改变时,其编码的PRS1活性也将发生改变,进而不仅会导致嘌呤和嘧... PRPS1基因编码的磷酸核糖焦磷酸合成酶(PRS)1是参与核酸合成的第一限速酶,其对细胞功能,特别是嘌呤、嘧啶相关的合成、代谢等有重要影响。当PRPS1基因突变引起PRS1晶体结构改变时,其编码的PRS1活性也将发生改变,进而不仅会导致嘌呤和嘧啶代谢紊乱,还会引起细胞能量代谢紊乱。此外,遗传性PRPS1基因突变会引起高耗能组织器官的功能异常,出现一系列的临床综合征。在肿瘤患者中也存在体细胞的PRPS1基因突变,可引起肿瘤耐药复发。总之,PRS1在能量代谢、细胞信号转导及核酸合成等方面发挥关键作用,对维持人体正常生理活动具有重要意义。笔者拟就PRPS1基因编码的PRS1在人体的生理功能和晶体结构、PRPS1基因及其突变对细胞代谢的调节及PRPS1基因突变相关临床综合征等方面进行综述。 展开更多
关键词 磷酸核糖焦磷酸 综合征 代谢 磷酸核糖焦磷酸合成酶 PRPS1基因
Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in ratsPentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats 预览
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作者 Slaven Gojkovic Ivan Krezic +14 位作者 Borna Vrdoljak Dominik Malekinusic Ivan Barisic andreja Petrovic Katarina Horvat Pavlov Marijan Kolovrat Antonija Duzel Mario Knezevic Katarina Kasnik Kovac Domagoj Drmic Lovorka Batelja Vuletic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric 《世界胃肠病理生理学杂志:英文版(电子版)》 2020年第1期1-19,共19页
BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion disturbances.BPC 157 was previously reviewed as novel mediator of R... BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion disturbances.BPC 157 was previously reviewed as novel mediator of Robert cytoprotection and endothelium protection in the stomach,and gut-brain axis,beneficial therapy in gastrointestinal tract,with particular reference to vascular recruitment,ulcerative colitis and tumor cachexia,and other tissues healing.Here we raised new hypothesis about BPC 157 therapy in the Budd-Chiari syndrome in rats,rapid bypassing of the suprahepatic inferior caval vein occlusion,and rats recovery with the active and effective pharmacotherapy treatment.AIM To investigate Budd-Chiari syndrome model(inferior caval vein suprahepatic occlusion)resolution,since BPC 157 resolves various rat vascular occlusion.METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt,counteracted caval/portal hypertension,aortal hypotension,venous/arterial thrombosis,electrocardiogram disturbances,liver and gastrointestinal lesions(i.e.,stomach and duodenum hemorrhages,in particular,congestion).Rats with suprahepatic occlusion of the inferior vena cava by ligation were medicated at 1 min,15 min,24 h,or 48 h post-ligation.Medication consisted of 10μg/kg BPC 157,10 ng BPC 157 or 5 m L/kg saline,administered once as an abdominal bath or intragastric application.Gross and microscopic observations were made,in addition to assessments of electrical activity of the heart(electrocardiogram),portal and caval hypertension,aortal hypotension,thrombosis,hepatomegaly,splenomegaly and venography.Furthermore,levels of nitric oxide,malondialdehyde in the liver and serum enzymes were determined.RESULTS BPC 157 counteracted increased P wave amplitude,tachycardia and ST-elevation,i.e.,right heart failure from acute thrombotic coronary occlusion.The bypassing pathway of the inferior vena cava-azygos(hemiazygos)vein-superior vena cava and portocaval shunt occurred rapidl 展开更多
关键词 BPC 157 Budd Chiari syndrome Portal/caval hypertension
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Effects of durotomy versus myelotomy in the repair of spinal cord injury 预览
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作者 Dionne Telemacque Feng-Zhao Zhu +7 位作者 Zheng-Wei Ren Kai-Fang Chen Deepak Drepaul Sheng Yao Fan Yang Yan-Zheng Qu Ting-Fang Sun Xiao-Dong Guo 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第10期1814-1820,共7页
Current management for spinal cord injury aims to reduce secondary damage and recover sensation and movement.Acute spinal cord injury is often accompanied by spinal cord compartment syndrome.Decompression by durotomy ... Current management for spinal cord injury aims to reduce secondary damage and recover sensation and movement.Acute spinal cord injury is often accompanied by spinal cord compartment syndrome.Decompression by durotomy and/or myelotomy attempts to relieve secondary damage by completelyrelieving the compression of the spinal cord,removing the necrotic tissue,decreasing edema,reducing hemorrhage,and improving blood circulation in the spinal cord.However,it is controversial whether durotomy and/or myelotomy after spinal cord injury are beneficial to neurological recovery.This review compares the clinical effects of durotomy with those of myelotomy in the treatment of spinal cord injury.We found that durotomy has been performed more than myelotomy in the clinic,and that durotomy may be safer and more effective than myelotomy.Durotomy performed in humans had positive effects on neurological function in 92.3% of studies in this review,while durotomy in animals had positive effects on neurological function in 83.3% of studies.Myelotomy procedures were effective in 80% of animal studies,but only one clinical study of myelotomy has reported positive results,of motor and sensory improvement,in humans.However,a number of new animal studies have reported that durotomy and myelotomy are ineffective for spinal cord injury.More clinical data,in the form of a randomized controlled study,are needed to understand the effectiveness of durotomy and myelotomy. 展开更多
关键词 decompression durotomy intraspinal pressure LAMINECTOMY MYELOTOMY neurological recovery spinal cord compartment syndrome spinal cord injury spinal cord interstitial pressure
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基于“咽胃相关”探析岭南慢性咽炎证候特征与胡玲教授辨治用药特色
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作者 叶晋通 胡玲 +7 位作者 张云展 代云凯 李丹艳 李欣如 黄孟欣 余莹 于唱 陈苇菁 《中国中西医结合消化杂志》 CAS 2020年第2期148-151,157共5页
胡玲教授师从于全国名老中医学术继承"优秀指导老师"、"劳九芝堂"中医世家第10代传人劳绍贤教授,其临床治疗慢性咽炎合并消化道疾病或不适症状之"咽胃相关"患者经验独到。该文对其岭南名医门诊534例慢性... 胡玲教授师从于全国名老中医学术继承"优秀指导老师"、"劳九芝堂"中医世家第10代传人劳绍贤教授,其临床治疗慢性咽炎合并消化道疾病或不适症状之"咽胃相关"患者经验独到。该文对其岭南名医门诊534例慢性咽炎病例资料进行聚类统计分析,探索"咽胃相关"慢性咽炎患者岭南证候的分布特征及胡玲教授辨治用药特色。结果提示,岭南地区"咽胃相关"慢性咽炎患者以脾胃湿热、肝胃不和、脾虚夹痰证型为多见。胡玲教授临证治疗该病以化湿清热、疏肝和胃、凉血散瘀为主,善用岭南道地药材,用药平和,并注重顾护胃气津液。 展开更多
关键词 咽胃相关 聚类分析 证候/岭南 名中医/经验
自身免疫性多发性内分泌腺病综合征1例并文献复习 预览
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作者 张丽婷 伍豪 +2 位作者 朱玲玲 蔡泉方 陈频 《中国医药导报》 CAS 2020年第3期164-167,共4页
本文报道1例自身免疫性多发性内分泌腺病综合征(APS)的临床资料,并进行文献复习,希望提高临床医生对该疾病的诊断和治疗。本例患者成年女性,2017年6月因“1型糖尿病”入中国人民解放军联勤保障部队第九一○医院治疗,2018年3月出现“桥... 本文报道1例自身免疫性多发性内分泌腺病综合征(APS)的临床资料,并进行文献复习,希望提高临床医生对该疾病的诊断和治疗。本例患者成年女性,2017年6月因“1型糖尿病”入中国人民解放军联勤保障部队第九一○医院治疗,2018年3月出现“桥本甲状腺炎”症状,患者于2019年6月检查提示“原发性性腺功能减退症”,确诊为“APSⅡ型”。根据病因和临床特征可以将APS分为2型:APSⅠ型和APSⅡ型。APSⅡ型包括1型糖尿病、Addison病和自身免疫性甲状腺疾病,合并两种即可诊断APSⅡ型。APS治疗主要是针对所累及的内分泌腺体给予相应的激素替代治疗及对症治疗。 展开更多
关键词 多腺体 自身免疫性 综合征 诊断 治疗
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Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model 预览
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作者 Jaeseung Shin Haesung Yoon +4 位作者 Yoon Jin Cha Kyunghwa Han Mi-Jung Lee Myung-Joon Kim Hyun Joo Shin 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第7期706-716,共11页
BACKGROUND Hepatic sinusoidal obstruction syndrome(SOS)is caused by damage to hepatic sinusoidal endothelial cells that results in fibrous obliteration of intrahepatic venules and necrosis of hepatocytes.Currently the... BACKGROUND Hepatic sinusoidal obstruction syndrome(SOS)is caused by damage to hepatic sinusoidal endothelial cells that results in fibrous obliteration of intrahepatic venules and necrosis of hepatocytes.Currently the diagnosis is primarily based on nonspecific clinical features and invasive liver biopsy.Therefore,noninvasive imaging methods are required for the early diagnosis and severity assessment of hepatic SOS.AIM To determine the effectiveness of supersonic shear wave imaging(SSI)and dual energy computed tomography(DECT)for diagnosing hepatic SOS using a rabbit model.METHODS Among nine New Zealand white rabbits(3-4 kg,male),three in control group ingested normal saline for 20 d and six in the SOS group ingested 6-thioguanine(5 mg/kg/d)for 20 d.Liver stiffness was measured using SSI on days 0,3,10,and 20.On the same days,liver perfusion was evaluated from virtual monochromatic images of 55 keV and iodine map using DECT.Morphologic changes in the liver were assessed using CT.Final pathology scores were compared between the two groups.Liver stiffness and perfusion parameters were compared according to the groups,days,and pathology scores.RESULTS Final pathology scores were significantly higher in the SOS than the control group(median 22 vs 2,P=0.024).No gross morphologic changes were seen in livers.Liver stiffness,Hounsfield Unit values,and iodine concentrations were higher in the SOS compared to the control group on days 10 and 20(all,P≤0.007).Compared to day 0,liver stiffness and perfusion parameters were higher on day 20 in the SOS group(all,P≤0.001).Correlation coefficients for liver stiffness(r=0.635),Hounsfield Unit values(r=0.587),and iodine concentration(r=0.611)with final pathology scores were positive without significance(all,P>0.05).CONCLUSION Liver stiffness and perfusion parameters were significantly increased in the livers of a rabbit SOS model.SSI and DECT might aid in early diagnosis of hepatic SOS. 展开更多
关键词 Hepatic sinusoidal obstruction syndrome Elasticity imaging techniques IODINE Computed tomography LIVER ANIMALS
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Effects of gender-affirming hormone therapy on insulin resistance and body composition in transgender individuals: A systematic review 预览
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作者 Cassandra Spanos Ingrid Bretherton +1 位作者 Jeffrey D Zajac Ada S Cheung 《世界糖尿病杂志:英文版(电子版)》 2020年第3期66-77,共12页
BACKGROUND Transgender individuals receiving masculinising or feminising gender-affirming hormone therapy with testosterone or estradiol respectively,are at increased risk of adverse cardiovascular outcomes,including ... BACKGROUND Transgender individuals receiving masculinising or feminising gender-affirming hormone therapy with testosterone or estradiol respectively,are at increased risk of adverse cardiovascular outcomes,including myocardial infarction and stroke.This may be related to the effects of testosterone or estradiol therapy on body composition,fat distribution,and insulin resistance but the effect of genderaffirming hormone therapy on these cardiovascular risk factors has not been extensively examined.AIM To evaluate the impact of gender-affirming hormone therapy on body composition and insulin resistance in transgender individuals,to guide clinicians in minimising cardiovascular risk.METHODS We performed a review of the literature based on PRISMA guidelines.MEDLINE,Embase and PsycINFO databases were searched for studies examining body composition,insulin resistance or body fat distribution in transgender individuals aged over 18 years on established gender-affirming hormone therapy.Studies were selected for full-text analysis if they investigated transgender individuals on any type of gender-affirming hormone therapy and reported effects on lean mass,fat mass or insulin resistance.RESULTS The search strategy identified 221 studies.After exclusion of studies that did not meet inclusion criteria,26 were included(2 cross-sectional,21 prospectiveuncontrolled and 3 prospective-controlled).Evidence in transgender men suggests that testosterone therapy increases lean mass,decreases fat mass and has no impact on insulin resistance.Evidence in transgender women suggests that feminising hormone therapy(estradiol,with or without anti-androgen agents)decreases lean mass,increases fat mass,and may worsen insulin resistance.Changes to body composition were consistent across almost all studies:Transgender men on testosterone gained lean mass and lost fat mass,and transgender women on oestrogen experienced the reverse.No study directly contradicted these trends,though several small studies of short duration reported no changes.Resu 展开更多
关键词 Transgender persons Insulin resistance Body composition Gender dysphoria Metabolic syndrome
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Acute Pancreatitis Complicated by Sheehan's Syndrome: A Case Report and Literature Review 预览
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作者 Dasheng Liu Li Liu +2 位作者 Feng Gan Xianlin Wu Gang Ye 《中国医学科学杂志:英文版》 CAS CSCD 2020年第1期95-100,共6页
A 44-year-old woman was transferred to the ICU of the First Affiliated Hospital of Jinan University for 2 days of persistent epigastric pain and 7 hours of unconsciousness.Her admission diagnosis was severe acute necr... A 44-year-old woman was transferred to the ICU of the First Affiliated Hospital of Jinan University for 2 days of persistent epigastric pain and 7 hours of unconsciousness.Her admission diagnosis was severe acute necrotizing pancreatitis(hypertriglyceridemia type)with multiple organ dysfunctions.The results of CT revealed a small area of necrotizing pancreatitis,which was not consistent with the severe clinical manifestations.Considering lack of hair and history of postpartum hemorrhage,hormone examination was carried out.According to the results of the examination,she was further diagnosed as Sheehan's syndrome and pituitary crisis.After hormone replacement therapy,her condition improved rapidly. 展开更多
关键词 acute pancreatitis Sheehan's syndrome pituitary crisis HYPERTRIGLYCERIDEMIA
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Traditional Chinese Medicine nursing protocols for colorectal polyps 预览
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作者 Editorial Board of Nursing of Integrated Traditional Chinese and Western Medicine 《中西医结合护理(中英文)》 2020年第1期202-206,共5页
Colorectal polyps are thought to be the potential precursors to colorectal cancer(CRC).Endoscopic removal of these polyps is conductive to decreasing the risk of deaths due to CRC,but for some complex colorectal polyp... Colorectal polyps are thought to be the potential precursors to colorectal cancer(CRC).Endoscopic removal of these polyps is conductive to decreasing the risk of deaths due to CRC,but for some complex colorectal polyps,they have to be resected surgically instead of endoscopic removal.However,surgical excision is associated with higher morbidity and mortality.Recently,traditional Chinese medicine(TCM)has shown a better therapeutic effect on improving the quality of life and reducing the recurrence in patients with colorectal polyps.Therefore,this article primarily investigated the key points of common syndromes,TCM nursing methods and healthy guidance of colorectal polyps,aiming at maintaining and developing the strengths of TCM,improving its efficacy and standardizing its behavior. 展开更多
关键词 colorectal polyps abdominal pain Traditional Chinese Medicine nursing syndrome differentiation
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炔雌醇环丙孕酮片、氯米芬对PCOS的作用 预览
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作者 饶亦良 《中国继续医学教育》 2020年第5期140-142,共3页
目的探讨炔雌醇环丙孕酮片以及采取氯米芬治疗多囊卵巢综合征不孕患者临床效果。方法选择武穴市第一人民医院产科100例2017年5月-2018年4月多囊卵巢综合征不孕患者。随机分组,氯米芬治疗组对于多囊卵巢综合征不孕患者使用的药物是氯米... 目的探讨炔雌醇环丙孕酮片以及采取氯米芬治疗多囊卵巢综合征不孕患者临床效果。方法选择武穴市第一人民医院产科100例2017年5月-2018年4月多囊卵巢综合征不孕患者。随机分组,氯米芬治疗组对于多囊卵巢综合征不孕患者使用的药物是氯米芬治疗,炔雌醇环丙孕酮片组对于多囊卵巢综合征不孕患者使用的药物是炔雌醇环丙孕酮片。比较两组临床疗效;激素指标改善时间;治疗前后多囊卵巢综合征不孕患者血清雌二醇、血清卵泡雌激素、血清黄体生成素。结果炔雌醇环丙孕酮片组临床疗效和氯米芬治疗组比较有优势,P<0.05,炔雌醇环丙孕酮片组(5.79±1.21)天内出现激素指标改善,而氯米芬治疗组激素指标开始改善的时间在(8.46±2.15)天。治疗前氯米芬治疗组、炔雌醇环丙孕酮片组血清雌二醇、血清卵泡雌激素、血清黄体生成素比较,P>0.05;治疗后炔雌醇环丙孕酮片组血清雌二醇、血清卵泡雌激素升高程度更大,血清黄体生成素降低程度更大P<0.05。结论炔雌醇环丙孕酮片治疗多囊卵巢综合征不孕效果好,可有效改善患者的内分泌水平,缩短病情好转的时间,提高治疗的效果。 展开更多
关键词 炔雌醇环丙孕酮片 氯米芬 多囊卵巢 综合征 不孕患者 临床效果
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Physical activity levels in American and Japanese men from the ERA-JUMP Study and associations with metabolic syndrome 预览
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作者 Naoko Sagawa Bonny Rockette-Wagner +7 位作者 Koichiro Azuma Hirotsugu Ueshima Takashi Hisamatsu Tomoko Takamiya Aiman El-Saed Katsuyuki Miura Andrea Kriska Akira Sekikawa 《运动与健康科学:英文版》 SCIE 2020年第2期170-178,共9页
Background:Metabolic syndrome(MetS) is a global health problem.Physical activity(PA) is a known modifiable risk factor for MetS and individual MetS components.However,the role of PA could differ between sub-population... Background:Metabolic syndrome(MetS) is a global health problem.Physical activity(PA) is a known modifiable risk factor for MetS and individual MetS components.However,the role of PA could differ between sub-populations due to differences in the variability of PA and other MetS risk factors.To examine these differences,multi-country studies with standardized outcome measurement methods across cohorts are needed.Methods:Cross-sectional PA levels(total and domain specific) in healthy middle-aged(44-56 years) men in the Risk Factor Assessment among Japanese and U.S.Men in the Post-World War Ⅱ Birth Cohort(ERA-JUMP) Study(n=730;American:n=417;Japanese:n=313;from population-representative samples in Pittsburgh,Pennsylvania,USA,and Kusatsu,Shiga,Japan) were compared.The relationships between PA levels and MetS(overall and specific components) in/across the American and Japanese sub-cohorts(adjusting for age,smoking,and alcohol consumption)were also assessed using the same instruments(pedometer and validated questionnaire) to measure PA in both cohorts.Results:A total of 510 individuals provided complete data on PA(American:n=265;Japanese:n=245).The American cohort had significantly lower mean±SD steps/day(7878±3399 steps/day) vs.the Japanese cohort(9055±3797 steps/day)(p <0.001) but had significantly higher self-reported moderate-vigorous leisure PA(American:15.9(7.4-30.3) metabolic task equivalent hours per week(MET-b/week) vs.Japanese:4.0(0-11.3) METh/week,p <0.0001).In both sub-cohorts,each 1000 steps/day increase was associated with lower odds of having MetS(American:OR=0.90,95%CI:0.83-0.98;Japanese:OR=0.87,95%CI:0.79-0.95) and the individual MetS component of high waist circumference(American:OR=0.86,95%CI:0.79-0.94;Japanese:OR=0.87,95%CI:0.80-0.95).In the American cohort only,higher self-reported leisure PA(Met-b/week) was associated with lower odds of MetS and high waist circumference(OR=0.98,95%CI:0.97-0.99 for MetS and waist circumference,respectively).Conclusion:Higher total step counts/day had an importa 展开更多
关键词 EPIDEMIOLOGY Metabolic syndrome PEDOMETER Physical activity QUESTIONNAIRE
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Clinical distribution and molecular profiling on postoperative colorectal cancer patients with different traditional Chinese medicine syndromes 预览
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作者 Li-Jun Jin Ying Liu +12 位作者 Ming-Ming Zhang Xue-Meng Han Qiu-Jie Li Yu Xiang Bing-Tao Zhai Peng Chen Xia-Ying Chen Wen-Gang Wang Shui-Ping Liu Duan Ting Jiao Feng Tian Xie Xin-Bing Sui 《TMR传统医学研究》 2020年第1期44-52,共9页
Background:Traditional Chinese medicine(TCM)syndrome,also named syndrome,are comprehensive and integral analyses of clinical information which helps to guide different individualized treatment prescriptions.Methods:Th... Background:Traditional Chinese medicine(TCM)syndrome,also named syndrome,are comprehensive and integral analyses of clinical information which helps to guide different individualized treatment prescriptions.Methods:Thirty healthy controls and 80 colorectal cancer(CRC)patients(including 33 Spleen Qi Deficiency syndrome,23 Dampness Heat syndrome,17 Blood Stasis syndrome and 7 other syndrome)were enrolled into this study.Human mRNAs were extracted from peripheral blood mononuclear cells.The gene expression for CRC patients with different TCM syndrome was determined by microarray and qRT-PCR.Results:Spleen Qi Deficiency,Dampness Heat and Blood Stasis were the most common syndromes in CRC patients.There is a significant difference was found in mRNA expression levels(especially for PIK3CA,STAT3,SOX9 and KDM5C)among Spleen Qi Deficiency,Dampness Heat and Blood Stasis syndrome groups.The higher mRNA levels of JNK1,TP53,MLH1,MSH6,PMS2,SOCS3,TCF7L2,FAM123B,PSAP,FBXW7,SALL4 and the lower expression of inflammatory cytokine IL-6 were found in Spleen Qi Deficiency group but not other syndrome types.The higher mRNA levels of KRAS,MUC16,EGFR,GRASP65,PIK3CA,MAPK7,CD24,STAT3,SLC11A1,Bcl-2,TXNDC17 and some inflammatory cytokines(IL-6,IL-23,TNF-a,CXCR4)were found in Dampness Heat group but not other syndrome types.Blood Stasis syndrome showed higher expression of SOX9,MLH1,MSH6,KDM5C,PCDH11X,PSAP and SALL4,and lower mRNA levels of PIK3CA,CD24,STAT3,CXCR4,TXNDC17 and TP53.The CRC patients with Dampness Heat syndrome might have a poor prognosis than other syndrome types.Conclusion:The identification of syndrome conditions had different impacts on CRC prognosis,and which might be related with different mRNA expression levels.Some oncogenes and pro-inflammatory cytokines were highly expressed in Dampness Heat group but not other syndrome types,suggesting that the CRC patients with Dampness Heat syndrome might have a poor prognosis.Our results prelimitarily uncovered the molecular basis of syndrome differences in CRC prognosis,a better 展开更多
关键词 Traditional Chinese medicine CLINICAL DISTRIBUTION Molecular PROFILING COLORECTAL cancer Syndrome differentiation Pattern diagnosis
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Malignant tumors associated with Peutz-Jeghers syndrome: Five cases from a single surgical unit 预览
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作者 Zhi Zheng Rui Xu +4 位作者 Jie Yin Jun Cai Guang-Yong Chen Jun Zhang Zhong-Tao Zhang 《世界临床病例杂志》 2020年第2期264-275,共12页
BACKGROUND Peutz-Jeghers syndrome(PJS) is an autosomal dominant inherited disease easily causing secondary malignant changes without effective treatments.AIM To assess the clinical characteristics, diagnosis, and trea... BACKGROUND Peutz-Jeghers syndrome(PJS) is an autosomal dominant inherited disease easily causing secondary malignant changes without effective treatments.AIM To assess the clinical characteristics, diagnosis, and treatment of malignant changes secondary to PJS.METHODS The clinical data of five patients with malignant changes secondary to PJS diagnosed and treated at Beijing Friendship Hospital from June 2014 to January 2017 were retrospectively analyzed;the follow-up ended in May 2018.RESULTS There were three male and two female patients with an average age of 43.6 years.Intestinal obstruction, intussusception, and abdominal pain were the first symptoms. Computed tomography and gastrointestinal imaging combined with endoscopy helped evaluate the depth of tumor infiltration and determine the need for radical resection. Three patients underwent surgery. Postoperative pathology confirmed adenocarcinoma, genetic test indicated STK11 mutation,and the patients received chemotherapy, including one who succumbed to tumor progression 6 months post-surgery. Other two patients underwent endoscopic resection, and postoperative pathology confirmed high grade intraepithelial neoplasia. The surviving patients had no recurrence by May 2018.CONCLUSION Endoscopy combined with computed tomography and gastrointestinal imaging is of great significance in the diagnosis and treatment of PJS, and pathological examination and gene detection are the gold standards for detecting malignant changes secondary to PJS. Some malignant polyps can be removed under endoscopy, and surgery is feasible when malignant polyps cannot be remove dunder an endoscope. For patients unable to achieve R0 resection, clinical symptoms should be relieved, and postoperative adjuvant chemotherapy could improve long-term prognosis. Meanwhile, close and regular surveillance should be conducted to prevent severe complications. 展开更多
关键词 Peutz-Jeghers syndrome MALIGNANT DIAGNOSIS SURGERY Treatment
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