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Therapeutic effect of regulating autophagy in spinal cord injury: a network meta-analysis of direct and indirect comparisons 预览
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作者 Duo Zhang Di Zhu +4 位作者 Fang Wang Ji-Chao Zhu Xu Zhai Yuan Yuan Chen-Xi Li 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1120-1132,共13页
Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,th... Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,the effect of regulating autophagy and whether autophagy is detrimental or beneficial after spinal cord injury remain unclear.Therefore,in this study we evaluated the effects of autophagy regulation on spinal cord injury in rats by direct and indirect comparison,in an effort to provide a basis for further research.Data source:Relevant literature published from inception to February 1,2018 were included by searching Wanfang,CNKI,Web of Science,MEDLINE(OvidSP),PubMed and Google Scholar in English and Chinese.The keywords included"autophagy","spinal cord injury",and"rat".Data selection:The literature included in vivo experimental studies on autophagy regulation in the treatment of spinal cord injury(including intervention pre-and post-spinal cord injury).Meta-analyses were conducted at different time points to compare the therapeutic effects of promoting or inhibiting autophagy,and subgroup analyses were also conducted.Outcome measure:Basso,Beattie,and Bresnahan scores.Results:Of the 622 studies,33 studies of median quality were included in the analyses.Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=1.80,95%CI:0.81-2.79,P=0.0004),3 days(MD=0.92,95%CI:0.72-1.13,P<0.00001),1 week(MD=2.39,95%CI:1.85-2.92,P<0.00001),2 weeks(MD=3.26,95%CI:2.40-4.13,P<0.00001),3 weeks(MD=3.13,95%CI:2.51-3.75,P<0.00001)and 4 weeks(MD=3.18,95%CI:2.43-3.92,P<0.00001)after spinal cord injury with upregulation of autophagy compared with the control group(drug solvent control,such as saline group).Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=6.48,95%CI:5.83-7.13,P<0.00001),2 weeks(MD=2.43,95%CI:0.79-4.07,P=0.004),3 weeks(MD=2.96,95%CI:0.09-5.84,P=0.04)and 4 weeks(MD=4.41,95%CI:1.08-7.75,P=0.01)after spinal cord injury with downregulation of autophagy compared with the control group.Indirect comparison of upr 展开更多
关键词 AUTOPHAGY Basso Beattie and Bresnahan scores indirect comparison META-ANALYSIS nerve regeneration neural regeneration neurological function rat models REGULATION spinal cord injury strategy analysis
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Protection of Intellectual Property and Authenticity of Chinese Herbal Medicine Chrysanthemum morifolium 预览
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作者 Yuanpeng SUN Yanling SUN +2 位作者 Xueqin SIMA Zhe WU Zheng CHENG 《药用植物研究(英文版)》 2019年第4期9-15,19共8页
This paper first introduced Chrysanthemum morifolium Ramat. and its medicinal value. Then, it studied agricultural intellectual property resources such as geographical indications, trademarks, patents, new plant varie... This paper first introduced Chrysanthemum morifolium Ramat. and its medicinal value. Then, it studied agricultural intellectual property resources such as geographical indications, trademarks, patents, new plant varieties, biological genetic resources, and traditional knowledge related to C. morifolium . Finally, it summarized poverty-stricken areas ecologically suitable for planting C. morifolium , analyzed the GAP certification of C. morifolium , pollution-free agricultural product certification, green food certification, and organic food certification, and discussed the strategies for C. morifolium intellectual property protection and authenticity protection in the context of TCM development strategy and rural revitalization strategy. 展开更多
关键词 CHRYSANTHEMUM morifolium Ramat Traditional Chinese medicine Agricultural intellectual property TCM development STRATEGY Rural REVITALIZATION STRATEGY
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Study on Agricultural Intellectual Property Protection and High-Quality Development of Traditional Chinese Medicine of Ginseng 预览
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作者 Yuanpeng SUN Zhe WU +2 位作者 Xueqin SIMA Yanling SUN Zheng CHENG 《亚洲农业研究:英文版》 2019年第6期5-11,共7页
Agricultural intellectual property has the functions of carrying forward agricultural cultural heritage,encouraging agricultural scientific and technological innovation,cultivating the brand of agricultural products a... Agricultural intellectual property has the functions of carrying forward agricultural cultural heritage,encouraging agricultural scientific and technological innovation,cultivating the brand of agricultural products and so on. The protection and application of agricultural intellectual property rights can enhance the vitality,innovation and competitiveness of agricultural economy,and promote the strategy of high-quality agricultural development and rural revitalization. Ginseng is a traditional medicinal variety with superior characteristics in Northeast China,and it is one of the most famous " three treasures" in Northeast China. This paper introduces ginseng( Panax ginseng C. A. Mey.) and its medicinal value,analyzes the traditional knowledge,biological genetic resources,new plant varieties,patents,geographical indications,trademarks and other agricultural intellectual property resources of ginseng,studies the traditional Chinese medicine GAP certification and certification of " Three Agricultural Products" and the construction of the dominant area of agricultural product( Fusong ginseng) with Chinese characteristics,and explores the rural revitalization strategy and traditional Chinese medicine development strategy,ginseng agricultural intellectual property protection and high quality development strategy. 展开更多
关键词 GINSENG TRADITIONAL CHINESE MEDICINE AGRICULTURAL intellectual property rights Development STRATEGY of TRADITIONAL CHINESE MEDICINE Rural revitalization STRATEGY
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Two-thousand years of debates and practices of Yellow River training strategies 预览
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作者 Zhaoyin Wang Cheng Liu 《国际泥沙研究:英文版》 SCIE 2019年第1期73-83,共11页
Throughout the history of China,the Yellow River has been associated with flood disasters and changes in the course of its lower reaches because of sedimentation.From 602 B.C.to 1949 the river experienced 1593 levee b... Throughout the history of China,the Yellow River has been associated with flood disasters and changes in the course of its lower reaches because of sedimentation.From 602 B.C.to 1949 the river experienced 1593 levee bursts,flooding vast areas,and claiming millions of human lives.The river shifted its main course by avulsion 26 times with the apex around Zhengzhou,resulting in devastating calamities and numerous old channels.Training of the Yellow River has a history of more than 3000 yr.Levee construction has been the major strategy for flood control.Two extremely different strategies has been proposed and practiced in the past 2000 yr,i.e.the“wide river and depositing sediment”strategy and the“narrow river and scouring sediment”strategy.This paper analyzes the levee breaches and flood disasters in the past 2000 yr and compares the results of the two extremely different strategies.The“narrow river and scouring sediment”strategy has only short term effects on levee breach control and flood mitigation.The“wide river and depositing sediment”strategy can essentially mitigate flood disasters and reduce levee breaches for a long term period of time.The“wide river and depositing sediment”strategy has been used and no levee breach has occurred in the past 67 yr,which has been the only periods of more than 50 yr with no levee breaches in the history of the Yellow River since 700 A.D.Modern flood and sedimentation management methods have also been introduced,and the strategy of applying the“widen the river and enhance the levees”approach for the upper and lower reaches management is proposed. 展开更多
关键词 Yellow RIVER LEVEE breaches AVULSION Wide RIVER and depositing SEDIMENT STRATEGY Narrow RIVER and SCOURING SEDIMENT STRATEGY
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Invasive versus conservative strategy in consecutive patients aged 80 years or older with non-ST-segment elevation myocardial infarction:a retrospective study in China 预览
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作者 Yong-Gang SUI Si-Yong TENG +5 位作者 Jie QIAN Yuan WU Ke-Fei DOU Yi-Da TANG Shu-Bin QIAO Yong-Jian WU 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第10期741-748,共8页
Objective To investigate whether the very elderly patients with non-ST-segment elevation myocardial infarction (NSTEMI) will benefit from an invasive strategy versus a conservative strategy. Methods 190 consecutive pa... Objective To investigate whether the very elderly patients with non-ST-segment elevation myocardial infarction (NSTEMI) will benefit from an invasive strategy versus a conservative strategy. Methods 190 consecutive patients aged 80 years or older with NSTEMI were included in the retrospective study from September 2014 to August 2017, of which 69 patients received conservative strategy and 121 patients received invasive strategy. The primary outcome was death. Multivariate Cox regression models were used to assess the statistical association between strategies and mortality. The survival probability was further analyzed. Results The primary outcome occurred in 17.4% patients in the invasive group and in 42.0% patients in the conservative group (P = 0.0002). The readmission rate in the invasive group (14.9%) was higher than that in the conservative group (7.2%). Creatinine level (OR = 1.01, 95% CI: 0.10–1.03, P = 0.05) and use of diuretic (OR = 3.65, 95% CI: 1.56–8.53, P = 0.003) were independent influential factors for invasive strategy. HRs for multivariate Cox regression models were 3.45 (95% CI: 1.77–6.75, P = 0.0003), 3.02 (95% CI: 1.52–6.01, P = 0.0017), 2.93 (95% CI: 1. 46–5.86, P = 0.0024) and 2.47 (95% CI: 1.20–5.07, P = 0.0137). Compared with the patients received invasive strategy, the conservative group had remarkably reduced survival probability with time since treatment (P < 0.001). Conclusions An invasive strategy is superior to a conservative strategy in reducing mortality of patients aged 80 years or older with NSTEMI. Our results suggest that an invasive strategy is more suitable for the very elderly patients with NSTEMI in China. 展开更多
关键词 CONSERVATIVE STRATEGY Death INVASIVE STRATEGY Non-ST-segment elevation myocardial infarction
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Uniform Pricing Strategy vs. Price Differentiation Strategy in the Presence of Cost Saving and Demand Increasing
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作者 CAI Qiang LUO Chunlin +1 位作者 TIAN Xin WANG Shouyang 《系统科学与复杂性学报:英文版》 SCIE EI CSCD 2019年第3期932-946,共15页
Price differentiation or discrimination strategy has been regarded as the best choice for firms with online and offline channels, however, recent years often witnessed the practices of the uniform pricing strategy. Th... Price differentiation or discrimination strategy has been regarded as the best choice for firms with online and offline channels, however, recent years often witnessed the practices of the uniform pricing strategy. This paper aims to address the question whether the uniform pricing strategy may be better for the manufacturer, when the uniform pricing strategy has a positive impact on increasing the ciistomer demand and reducing the operations cost. The research shows that the uniform pricing strategy can be bet ter than the price differentiation strategy when the cost saving and demand increasing are large enough or the consumers' acceptance of online channel lies in a certain interval. Moreover, the manufac tu rers or brand owners need a tradeoff bet ween the benefit from online channel and the negative impact from the offline channel when they implement the price differentiation strategy. Finally, the authors obtain some managerial insights and implications based on the numerical analyses, which are in line with the phenomena in practice. 展开更多
关键词 Cost saving DEMAND INCREASING DUAL-CHANNEL PRICE differentiation STRATEGY UNIFORM pricing STRATEGY
论加强公安战略研究、战略思维和战略管理 预览
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作者 张兆端 《警学研究》 2019年第4期45-58,共14页
公安战略是指党和政府、公安机关关于公安队伍建设和公安工作长远性、全局性、高层次重大问题的筹划与指导。为有效履行新时代公安机关担负的维护国家政治安全,确保社会大局稳定,促进社会公平正义和保障人民安居乐业的重大职责使命,适... 公安战略是指党和政府、公安机关关于公安队伍建设和公安工作长远性、全局性、高层次重大问题的筹划与指导。为有效履行新时代公安机关担负的维护国家政治安全,确保社会大局稳定,促进社会公平正义和保障人民安居乐业的重大职责使命,适应全面深化公安改革的战略需要,公安机关应当在公安理论和公安指导上重视、加强公安战略研究,在领导干部能力建设上着重培养公安战略思维,在组织管理和警务指挥上全面实施公安战略管理。 展开更多
关键词 战略 公安战略研究 公安战略思维 公安战略管理
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New Sino-US Strategic Gambling and China’s Strategy 预览
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作者 Wang Honggang 《现代国际关系:英文版》 2019年第4期75-91,共17页
Since confidence is fading and anxiety is increasing in the US,America’s China policy has become more radical. In the short term, the US has the upper hand and China is in a relatively passive position. In the medium... Since confidence is fading and anxiety is increasing in the US,America’s China policy has become more radical. In the short term, the US has the upper hand and China is in a relatively passive position. In the medium-and long-term, there will be more balance between them. This current strategic gambling between China and the US will be the major issue of international politics in the first half of the 21 st century and the most prominent external challenge China faces. China needs to make strategic adjustments but the gamble may be worthwhile in correcting imbalance in the international order and in the co-evolution of the two countries. 展开更多
关键词 Sino-US RELATIONS STRATEGIC GAMBLING US STRATEGY TOWARD China China’s STRATEGY TOWARD the US
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当前医院经济管理面临的问题及对策 预览 被引量:1
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作者 张洪雷 《中国卫生产业》 2019年第5期134-135,共2页
经济市场内部与外部的环境变化,使得医疗领域的竞争越来越激烈,导致了医院经济管理工作面临着许多的困难。为了在未来的经济市场站稳脚跟,需要每一个医疗机构不断完善自身的经济管理制度来迎接未来的种种挑战。该文就当前医院经济管理... 经济市场内部与外部的环境变化,使得医疗领域的竞争越来越激烈,导致了医院经济管理工作面临着许多的困难。为了在未来的经济市场站稳脚跟,需要每一个医疗机构不断完善自身的经济管理制度来迎接未来的种种挑战。该文就当前医院经济管理面临的问题及对策做出研究与探讨。 展开更多
关键词 医疗机构 经济管理 问题 对策
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基于核心素养视角下的大学体育课程改革
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作者 王晓瑭 《中国多媒体与网络教学学报(电子版)》 2019年第6期193-194,共2页
经济的不断发展,对大学生的综合素质要求也越来越高,其中身体素质就是非常重要的一个指标。而大学体育课程在提升学生身体素质方面、锻炼学生毅力等方面都发挥这种着重要作用。如何更好的完成大学体育课程改革就成了众多高校教师关注的... 经济的不断发展,对大学生的综合素质要求也越来越高,其中身体素质就是非常重要的一个指标。而大学体育课程在提升学生身体素质方面、锻炼学生毅力等方面都发挥这种着重要作用。如何更好的完成大学体育课程改革就成了众多高校教师关注的话题,基于此本文选取了核心素养这一视角对大学体育课程改革展开探究。 展开更多
关键词 核心素养 大学体育 课程改革 意义 策略
高中生物理建模能力培养策略探微 预览
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作者 陈素英 《当代教研论丛》 2019年第4期65-65,67共2页
物理建模能帮助学生构建完善的物理知识体系,更能化难为易,以简驭繁,加深学生对物理知识的理解与掌握。在高中物理教学实践中,教师应培养学生建模能力,增强学生建模思维,如此才能提升学生物理素养。本文分析了培养学生物理建模能力的意... 物理建模能帮助学生构建完善的物理知识体系,更能化难为易,以简驭繁,加深学生对物理知识的理解与掌握。在高中物理教学实践中,教师应培养学生建模能力,增强学生建模思维,如此才能提升学生物理素养。本文分析了培养学生物理建模能力的意义,结合实践教学经验,探讨了培养高中生物理建模能力的策略。 展开更多
关键词 高中生 物理 建模能力 策略
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苏南县域科技创新战略研究 预览
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作者 庞诚 李梅 《科技创新与应用》 2019年第32期182-183,共2页
自从新世纪以来,苏南县域在科技管理方面切实加大力度,同时在科技政策方面进行不断调整健全,目前已经创建了一套相对完善的技术创新服务机制,同时以科技孵化器作为核心的全新服务体系正逐渐成型,目前在科技创新方面已经取得巨大突破,成... 自从新世纪以来,苏南县域在科技管理方面切实加大力度,同时在科技政策方面进行不断调整健全,目前已经创建了一套相对完善的技术创新服务机制,同时以科技孵化器作为核心的全新服务体系正逐渐成型,目前在科技创新方面已经取得巨大突破,成绩斐然。然而如果进行深入分析,不难发现,目前在科技管理层面仍存在不少问题,同时难题也比较多,尤其在创新方面遇到了很大挑战。当然需要承认的是,苏南县域在科技方面进行大力度改革创新,以此取得的成功对全国其他地方有很好的借鉴意义。 展开更多
关键词 苏南县域 科技创新 战略 研究
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云南边境地区旅游空间整合与策略研究 预览 被引量:1
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作者 郭向阳 明庆忠 丁正山 《学术探索》 2019年第2期90-97,共8页
边境地区旅游是全域旅游视角下的旅游新业态,对边境地区存在的问题深入剖析,对其旅游提质增效发展意义重大。本文以云南边境地区为研究案例,对其旅游发展存在的主要问题进行探究,并从旅游空间整合、开展跨国旅游合作与交流、大力发展边... 边境地区旅游是全域旅游视角下的旅游新业态,对边境地区存在的问题深入剖析,对其旅游提质增效发展意义重大。本文以云南边境地区为研究案例,对其旅游发展存在的主要问题进行探究,并从旅游空间整合、开展跨国旅游合作与交流、大力发展边疆民族地方经济巩固旅游发展基础、加强边境地区旅游运行保障措施体系建设等方面提出了云南省边境地区旅游提质增效发展策略。 展开更多
关键词 边境旅游 边境地区 空间整合 策略 云南省
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Research on the Computer Simulation Training Methods of Taekwondo Athletes before Competitions 预览
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作者 JIN Jun 《国际英语教育研究:英文版》 2019年第2期30-32,共3页
In Taekwondo competitions,the competition venues,the on-the-spot environment and the athletes'own tension and other factors have certain effects on the athletes'sports performances.Therefore,through the formul... In Taekwondo competitions,the competition venues,the on-the-spot environment and the athletes'own tension and other factors have certain effects on the athletes'sports performances.Therefore,through the formulation of the training plans during the competition period,we should ensure the adequate sleep,the reasonable diet,the adequate preparation activities,and the sufficient psychological preparation before the competitions,so that athletes can achieve excellent results.Based on the analysis of the pre-competition computer simulation training methods,this paper puts forward several specific research strategies. 展开更多
关键词 TAEKWONDO ATHLETES PRE-COMPETITION SIMULATION training COMPUTER SIMULATION strategy
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旅游度假区总体规划设计——以湖南省临武县通天山龙宫景区为例 预览
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作者 刘亚龙 向毅 《住宅科技》 2019年第10期21-26,共6页
近年来,旅游业得到突飞猛进的发展,文章介绍了旅游度假区的概念及国内研究现状,以湖南省临武县通天山龙宫景区旅游度假区为例,从机遇与挑战、定位与策略、规划布局三个环节展开论述,尝试为湖南旅游度假区高质量建设与发展提供参考。
关键词 旅游度假区 策略 布局
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我国呼吸学科发展的PEST分析及策略建议
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作者 纪婷婷 张鹏俊 +3 位作者 彭博 许扬 罗翔予 王辰 《中华医院管理杂志》 CSCD 北大核心 2019年第5期431-435,共5页
呼吸系统疾病种类多,影响人口基数大,发病率、患病率、致残率及死亡率高,对我国人民健康产生严重危害。本研究釆用PEST分析法,从政治环境、经济环境、社会文化环境和技术环境4个方面,分析我国呼吸学科所处的宏观环境,对其发展的现状和... 呼吸系统疾病种类多,影响人口基数大,发病率、患病率、致残率及死亡率高,对我国人民健康产生严重危害。本研究釆用PEST分析法,从政治环境、经济环境、社会文化环境和技术环境4个方面,分析我国呼吸学科所处的宏观环境,对其发展的现状和问题进行客观评价,据此提出策略建议,以期为呼吸学科发展提供理论依据。 展开更多
关键词 呼吸病学 学科发展 PEST分析 策略
增强现实技术下的高职院教学资源库构建研究 预览
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作者 杨加 《无线互联科技》 2019年第10期145-146,共2页
文章探讨了高职院校构建教学资源库的必要性和价值,并在遵循教学资源库建构逻辑的基础上,对高职院校教学资源库一体化设计的方向以及结构化课程和资源的内容进行必要的分析,着重阐述了促进教学资源库应用功能优化、共享机制创新和资源... 文章探讨了高职院校构建教学资源库的必要性和价值,并在遵循教学资源库建构逻辑的基础上,对高职院校教学资源库一体化设计的方向以及结构化课程和资源的内容进行必要的分析,着重阐述了促进教学资源库应用功能优化、共享机制创新和资源供给多元化发展的策略和方法,旨在通过高职院校教学资源库的构建,达到教学理念和教学水平的全面提升。 展开更多
关键词 高职院校 教学资源库 价值 内容 逻辑 策略
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关于商业银行如何实现有效扶贫的探究 预览
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作者 王涛 《财经与管理》 2019年第1期59-61,共3页
扶贫是是一项艰苦且需要持之以恒的事业,但在脱贫攻坚战中,由谁来实施是关键性问题。而商业银行的资金实力雄厚,并且还具有专业的风控手段,因此是进行金融扶贫工作的不二选择。本文分析了商业银行在扶贫工作中的困难,并对商业银行如何... 扶贫是是一项艰苦且需要持之以恒的事业,但在脱贫攻坚战中,由谁来实施是关键性问题。而商业银行的资金实力雄厚,并且还具有专业的风控手段,因此是进行金融扶贫工作的不二选择。本文分析了商业银行在扶贫工作中的困难,并对商业银行如何实现扶贫的有效性进行了研究. 展开更多
关键词 商业银行 扶贫 策略
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传统小型服装企业互联网思维应用启示
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作者 马晓倩 《黑龙江纺织》 2019年第3期39-41,共3页
以小型服装企业为例,分析传统小型服装企业当前存在的主要问题,运用互联网思维突破创新,实现产品、质量、技术等方面升级,摆脱现实困境,实现经营目标。
关键词 小型服装企业 互联网思维 策略
初中物理分组实验教学的矛盾分析与解决策略 预览 被引量:2
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作者 宋文东 《物理通报》 2019年第2期87-89,共3页
物理教学离不开实验,学生实验教学的有效开展对培养学生的学习兴趣、探究能力、创新意识以及科学态度、科学精神等起到至关重要的作用.实际上,在农村中学物理学科学生分组实验教学的开展过程中,客观上和主观上都存在着许多矛盾冲突.这... 物理教学离不开实验,学生实验教学的有效开展对培养学生的学习兴趣、探究能力、创新意识以及科学态度、科学精神等起到至关重要的作用.实际上,在农村中学物理学科学生分组实验教学的开展过程中,客观上和主观上都存在着许多矛盾冲突.这些矛盾严重影响和制约了学生实验的正常有效开展,为学生学好物理制造了较大的障碍.着力解除矛盾,为学生的学习铺平道路,是我们各级相关部门、学校、教师共同承担的责任和义务. 展开更多
关键词 农村 物理 分组实验 矛盾 策略
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