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Changes in sensorimotor regions of the cerebral cortex in congenital amusia:a case-control study 认领
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作者 Jun-Jie Sun Xue-Qun Pan +4 位作者 Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu 《中国神经再生研究:英文版》 SCIE CAS 2021年第3期531-536,共6页
Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little... Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little attention has been paid to the changes in the motor rain within congenital amusia.In this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group.We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network.We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores.In conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia.Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination.The study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(No.WDX20180101GZ01)on February 9,2019. 展开更多
关键词 congenital amusia degree centrality lifelong impairment local functional connectivity music discrimination primary motor area primary sensorimotor area primary sensory area resting-state functional magnetic resonance imaging voxel-based analysis
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儿童原发性1型高草酸尿症一例报道并文献复习 认领
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作者 周旭东 赵兴华 +2 位作者 许长宝 李武学 赵永立 《中国全科医学》 CAS 北大核心 2021年第9期1148-1151,共4页
原发性1型高草酸尿症(PH1)是一种常染色体隐性遗传病,临床表现为反复的肾脏结石和进行性肾钙质沉着症,通常在儿童期起病,病情呈进行性加重,最终会进展为终末期肾病。目前对于PH1的诊断,AGXT基因测序已经逐渐取代肝穿刺活检成为首选的诊... 原发性1型高草酸尿症(PH1)是一种常染色体隐性遗传病,临床表现为反复的肾脏结石和进行性肾钙质沉着症,通常在儿童期起病,病情呈进行性加重,最终会进展为终末期肾病。目前对于PH1的诊断,AGXT基因测序已经逐渐取代肝穿刺活检成为首选的诊断方法;PH1早期治疗主要为保守治疗。本文通过报道1例诊断明确的PH1患儿,分析并总结PH1的临床特征及管理方法,旨在为临床医生早期诊治该病提供参考。 展开更多
关键词 高草酸尿症 原发性 原发性1型高草酸尿症 尿液成分分析 基因检测 AGXT基因
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Estimation of carbon storage of forest biomass for voluntary carbon markets:preliminary results 认领
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作者 Luca Nonini Marco Fiala 《林业研究:英文版》 SCIE CAS 2021年第1期329-338,共10页
Estimating the carbon storage of forests is essential to support climate change mitigation and promote the transition into a low-carbon emission economy.To achieve this goal,voluntary carbon markets(VCMs)are essential... Estimating the carbon storage of forests is essential to support climate change mitigation and promote the transition into a low-carbon emission economy.To achieve this goal,voluntary carbon markets(VCMs)are essential.VCMs are promoted by a spontaneous demand,not imposed by binding targets,as the regulated ones.In Italy,only in Veneto and Piedmont Regions(Northern Italy),VCMs through forestry activities were carried out.Valle Camonica District(Northern Italy,Lombardy Region)is ready for a local VCM,but carbon storage of its forests was never estimated.The aim of this work was to estimate the total carbon storage(TCS;t C ha^−1)of forest biomass of Valle Camonica District,at the stand level,taking into account:(1)aboveground biomass,(2)belowground biomass,(3)deadwood,and(4)litter.We developed a user-friendly model,based on site-specifi c primary(measured)data,and we applied it to a dataset of 2019 stands extracted from 45 Forest Management Plans.Preliminary results showed that,in 2016,the TCS achieved 76.02 t C ha^−1.The aboveground biomass was the most relevant carbon pool(48.86 t C ha^−1;64.27%of TCS).From 2017 to 2029,through multifunctional forest management,the TCS could increase of 2.48 t C ha^−1(+3.26%).In the same period,assuming to convert coppices stands to high forests,an additional TCS of 0.78 t C ha^−1(equal to 2.85 t CO 2 ha^−1)in the aboveground biomass could be achieved without increasing forest areas.The additional carbon could be certifi ed and exchanged on a VCM,contributing to climate change mitigation at a local level. 展开更多
关键词 Carbon storage assessment Forest management plan Site-specifi c primary data Voluntary carbon market Climate change mitigation
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Recurrent inverted papilloma coexisted with skull base lymphoma: A case report 认领
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作者 Heng Juei Hsu Chi Chen Huang +3 位作者 Ming Tsung Chuang Chih Hao Tien Jung Shun Lee Po-Hsuan Lee 《世界临床病例杂志》 SCIE 2021年第2期516-520,共5页
BACKGROUND Inverted papilloma is an uncommon neoplasm in the nasal cavity.It is a histologically benign tumor,but has a high recurrence and local invasion rate.In addition,nasal or skull base lymphoma is another rare ... BACKGROUND Inverted papilloma is an uncommon neoplasm in the nasal cavity.It is a histologically benign tumor,but has a high recurrence and local invasion rate.In addition,nasal or skull base lymphoma is another rare neoplasm.The coexistence of these two tumors in one case makes the diagnosis and related treatment difficult.CASE SUMMARY We report a case of an immunocompetent patient,who had a history of inverted papilloma 20 years ago.The patient presented with an infiltrated mass lesion in the nasal cavity with extension to the frontal base.The repeated biopsies revealed inverted papilloma without any malignant transformation.After the patient underwent a frontobasal craniotomy with total tumor excision,the final pathological examination revealed nasal inverted papilloma coexisting with diffuse large B-cell lymphoma of the skull base.CONCLUSION Based on this case report,while managing a case of an aggressive recurrent inverted papilloma,not only squamous cell carcinoma transformation,but also other invasive malignancy,such as lymphoma,should be considered. 展开更多
关键词 Coexisting tumors Inverted papilloma Primary central nervous system lymphoma Skull base Squamous cell carcinoma Case report
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Effect of remote ischemic preconditioning among donors and recipients following pediatric liver transplantation:A randomized clinical trial 认领
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作者 Bo Qi Xiao-Qiang Wang +5 位作者 Shu-Ting Pan Pei-Ying Li Ling-Ke Chen Qiang Xia Li-Qun Yang Wei-Feng Yu 《世界胃肠病学杂志:英文版》 SCIE CAS 2021年第4期345-357,共13页
BACKGROUND Studies suggested that remote ischemic preconditioning(RIPC)may effectively lessen the harmful effects of ischemia reperfusion injury during organ transplantation surgery.AIM To investigate the protective e... BACKGROUND Studies suggested that remote ischemic preconditioning(RIPC)may effectively lessen the harmful effects of ischemia reperfusion injury during organ transplantation surgery.AIM To investigate the protective effects of RIPC on living liver donors and recipients following pediatric liver transplantation.METHODS From January 2016 to January 2019 at Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine,208 donors were recruited and randomly assigned to four groups:S-RIPC group(no intervention;n=55),D-RIPC group(donors received RIPC;n=51),R-RIPC group(recipients received RIPC,n=51)and DR-RIPC group(both donors and recipients received RIPC;n=51).We primarily evaluated postoperative liver function among donors and recipients and incidences of early allograft dysfunction,primary nonfunction and postoperative complications among recipients.RESULTS RIPC did not significantly improve alanine transaminase and aspartate aminotransferase levels among donors and recipients or decrease the incidences of early allograft dysfunction,primary nonfunction,and postoperative complications among recipients.Limited protective effects were observed,including a lower creatinine level in the D-RIPC group than in the S-RIPC group on postoperative day 0(P<0.05).However,no significant improvements were found in donors who received RIPC.Furthermore,RIPC had no effects on the overall survival of recipients.CONCLUSION The protective effects of RIPC were limited for recipients who received living liver transplantation,and no significant improvement of the prognosis was observed in recipients. 展开更多
关键词 Pediatric liver transplantation Remote ischemic preconditioning Postoperative complications Ischemia reperfusion injury Primary nonfunction HEPATOLOGY
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原发性三叉神经痛微血管减压术后复发的相关因素分析 认领
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作者 牛纪杰 孟祥富 +4 位作者 聂秀涛 黄宝辰 胡庆雷 陈维杰 张玉海 《中国微侵袭神经外科杂志》 CAS 2021年第1期20-23,共4页
目的探讨原发性三叉神经痛病人经微血管减压术(microvascular decompression,MVD)治疗后复发的危险因素。方法回顾性分析261例经MVD手术的原发性三叉神经痛病人的临床资料。行单因素卡方检验和Logistic多因素回归分析术后复发的独立危... 目的探讨原发性三叉神经痛病人经微血管减压术(microvascular decompression,MVD)治疗后复发的危险因素。方法回顾性分析261例经MVD手术的原发性三叉神经痛病人的临床资料。行单因素卡方检验和Logistic多因素回归分析术后复发的独立危险因素。结果本组原发性三叉神经痛总复发率为14.9%。单因素分析结果显示:性别、血管压迫程度、责任血管类型、术前磁共振断层血管成像(magnetic resonance tomographic angiography,MRTA)检查是否有血管压迫、术中是否使用神经内镜辅助及Teflon棉片使用方法与术后复发具有相关性(P<0.05)。多因素Logistic回归分析显示:女性、血管压迫程度(无压迫和重度压迫)、静脉及无血管压迫、术前MRTA检查无明显血管压迫是术后复发的独立危险因素,而Teflon棉絮包绕法是保护因素(P<0.05)。结论术前MRTA检查结果有利于判断预后;术中采用Teflon棉絮包绕法分离神经血管接触可减少术后复发;对无明显责任血管压迫者,建议行三叉神经感觉根切断术。 展开更多
关键词 三叉神经痛 原发性 微血管减压术 复发 术后 危险因素
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Risk factors for intraocular metastasis of primary liver cancer in diabetic patients:Alpha-fetoprotein and cancer antigen 125 认领
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作者 Kang Yu Jing Tang +9 位作者 Jie-Li Wu Biao Li Shi-Nan Wu Meng-Yao Zhang Qiu-Yu Li Li-Juan Zhang Yi-CongPan Qian-Min Ge Hui-Ye Shu Yi Shao 《世界糖尿病杂志:英文版(电子版)》 SCIE CAS 2021年第2期158-169,共12页
BACKGROUND In rare instances,primary liver cancer can be associated with intraocular metastasis(IOM).AIM To investigate the correlation between a diverse range of clinical characteristics and IOM in diabetic patients ... BACKGROUND In rare instances,primary liver cancer can be associated with intraocular metastasis(IOM).AIM To investigate the correlation between a diverse range of clinical characteristics and IOM in diabetic patients with primary liver cancer,and to determine potential risk factors in predicting IOM.METHODS We recruited a total of 722 diabetic patients with primary liver cancer.The differences between the IOM and non-intraocular metastasis(NIOM)groups in these patients were assessed using the chi-squared test and Student’s t-test.Binary logistic regression analysis was subsequently used to determine risk factors.Finally,the diagnostic value of IOM in this cohort with primary liver cancer was analyzed by receiver operating characteristic(ROC)curve analysis.RESULTS In all,13 patients had IOM.There were no remarkable intergroup differences with respect to age,sex,histopathological sub-types,or blood biochemical parameters.However,the IOM group had significantly higher alpha-fetoprotein(AFP)and cancer antigen 125(CA125)values than the NIOM group.Binary logistic regression identified AFP and CA125 to be significant risk factors for IOM in diabetic patients with primary liver cancer.ROC curve analysis showed that the area under the curve values for AFP and CA125 were 0.727 and 0.796,with the cut-off values of 994.20 ng/mL and 120.23 U/mL,respectively.The sensitivity and specicity for AFP were 92.3%and 59.9%,while those for CA125 were 84.6%and 70.1%,respectively.CONCLUSION Elevated AFP and CA125 represent significant risk factors for IOM in diabetic patients with primary liver cancer. 展开更多
关键词 Primary liver cancer Intraocular metastasis DIABETES ALPHA-FETOPROTEIN Cancer antigen 125 Risk factors
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Metabolic responses to combined water deficit and salt stress in maize primary roots 认领
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作者 LI Peng-cheng YANG Xiao-yi +6 位作者 WANG Hou-miao PAN Ting YANG Ji-yuan WANG Yun-yun XU Yang YANG Ze-feng XU Chen-wu 《农业科学学报:英文版》 SCIE CAS 2021年第1期109-119,共11页
Soil water deficit and salt stress are major limiting factors of plant growth and agricultural productivity. The primary root is the first organ to perceive the stress signals for drought and salt stress. In this stud... Soil water deficit and salt stress are major limiting factors of plant growth and agricultural productivity. The primary root is the first organ to perceive the stress signals for drought and salt stress. In this study, maize plant subjected to drought, salt and combined stresses displayed a significantly reduced primary root length relative to the control plants. GC-MS was used to determine changes in the metabolites of the primary root of maize in response to salt, drought and combined stresses. A total of 86 metabolites were measured, including 29 amino acids and amines, 21 organic acids, four fatty acids, six phosphoric acids, 10 sugars, 10 polyols, and six others. Among these, 53 metabolites with a significant change under different stresses were identified in the primary root, and the content of most metabolites showed down-accumulation. A total of four and 18 metabolites showed significant up-and down-accumulation to all three treatments, respectively. The levels of several compatible solutes, including sugars and polyols, were increased to help maintain the osmotic balance. The levels of metabolites involved in the TCA cycle, including citric acid, ketoglutaric acid, fumaric acid, and malic acid, were reduced in the primary root. The contents of metabolites in the shikimate pathway, such as quinic acid and shikimic acid, were significantly decreased. This study reveals the complex metabolic responses of the primary root to combined drought and salt stresses and extends our understanding of the mechanisms involved in root responses to abiotic tolerance in maize. 展开更多
关键词 MAIZE primary root combination stress DROUGHT high salt stress metabolomics
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Coinheritance of OLFM2 and SIX6 variants in a Chinese family with juvenile-onset primary open-angle glaucoma: A case report 认领
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作者 Xue Yang Nan-Nan Sun +6 位作者 Zhen-Ni Zhao Shu-Xiang He Miao Zhang Dan-Dan Zhang Xiao-Wei Yu Jia-Min Zhang Zhi-Gang Fan 《世界临床病例杂志》 SCIE 2021年第3期697-706,共10页
BACKGROUND Juvenile-onset primary open-angle glaucoma(JOAG),characterized by severe elevation of intraocular pressure and optic neuropathy prior to the age of 40,is a rare subtype of primary open-angle glaucoma.Severa... BACKGROUND Juvenile-onset primary open-angle glaucoma(JOAG),characterized by severe elevation of intraocular pressure and optic neuropathy prior to the age of 40,is a rare subtype of primary open-angle glaucoma.Several genetic mutations have been associated with JOAG.CASE SUMMARY The proband patient was a young male,diagnosed with primary open-angle glaucoma at the age of 27.The patient and his unaffected parents who have been excluded from classic genetic mutations for primary open-angle glaucoma were included to explore for other possible genetic variants through whole genome sequencing and bioinformatics analysis.In this trio,we found two heterozygous variants inherited from the parents in the proband:c.281G>A,p.Arg94His in OLFM2 and c.177C>G,p.Ile59Met in SIX6.Both genetic mutations are predicted through bioinformatics analysis to replace evolutionary conserved amino acids,therefore rendering a pathogenic effect on proteins.In contrast,very low frequencies for these genetic mutations were recorded in most common control databases.CONCLUSION This is the first report on coinherited mutations of OLFM2 and SIX6 in a JOAG family,which shows the complexity of JOAG inheritance.Large-scale clinical screening and molecular functional investigations on these coinherited mutations are imperative to improve our understanding of the development of JOAG. 展开更多
关键词 Juvenile-onset primary open-angle glaucoma Whole genome sequencing Coinheritance OLFM2 SIX6 Case report
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Primary nonkeratinizing squamous cell carcinoma of the scapular bone:A case report 认领
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作者 Yang Li Jian-Lin Zuo +3 位作者 Jin-Shuo Tang Xian-Yue Shen Sheng-Hao Xu Jian-Lin Xiao 《世界临床病例杂志》 SCIE 2021年第4期976-982,共7页
BACKGROUND Squamous cell carcinoma(SCC)of bone is usually caused by metastasis from the lungs,bladder,or other sites.Primary SCC of bone most frequently involves the skull bones,and primary involvement of other sites ... BACKGROUND Squamous cell carcinoma(SCC)of bone is usually caused by metastasis from the lungs,bladder,or other sites.Primary SCC of bone most frequently involves the skull bones,and primary involvement of other sites in the skeletal system is extremely rare.To date,only three such cases have been reported,which makes the diagnosis,treatment,and prognosis of this disease a challenge.CASE SUMMARY A 76-year-old Chinese man presented to our hospital with nonspecific pain and limited mobility in the right shoulder for 4 mo.He underwent three-dimensional computed tomography reconstruction and magnetic resonance imaging of the right shoulder,which revealed an osteolytic destructive lesion in the right scapula with invasion into the surrounding muscles and soft tissues.Ultrasound-guided core needle biopsy detected a malignant tumor,and immunohistochemical analysis revealed a poorly differentiated SCC.Wide excision of the right scapular bone was performed,and pathological examination of the surgical specimen confirmed the diagnosis.At the last follow-up examination within 2 years,the patient was doing well with the pain significantly relieved in the right shoulder.CONCLUSION Primary SCC of bone is extremely rare at sites other than the skull.Clinicians must exhaust all available means for the diagnosis of primary SCC of the bone,so greater attention can be paid to its timely and effective management.Regular and adequate follow-up is essential to help rule out metastasis and judge the prognosis. 展开更多
关键词 Primary squamous cell carcinoma Keratin pearls Scapular bone DIAGNOSIS IMMUNOHISTOCHEMISTRY Case report
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Perioperative mortality of metastatic spinal disease with unknown primary: A case report and review of literature 认领
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作者 Xiu-Mao Li Li-Bin Jin 《世界临床病例杂志》 SCIE 2021年第2期379-388,共10页
BACKGROUND Spinal metastases are common in patients with malignancies,but studies on those metastasized from unknown primaries are scarce due to the difficulty in treatment and the relatively poor prognosis.Knowledge ... BACKGROUND Spinal metastases are common in patients with malignancies,but studies on those metastasized from unknown primaries are scarce due to the difficulty in treatment and the relatively poor prognosis.Knowledge of surgical complications,particularly perioperative mortality,in patients with spinal metastases from unidentified sources is still insufficient.CASE SUMMARY A 54-year-old man with chest-back pain was diagnosed with spinal metastasis in the seventh thoracic vertebra(T7).Radiographic examinations,as well as needle biopsy and immunohistochemical tests were performed to verify the characteristics of the lesion,resulting in an inconclusive diagnosis of poorly differentiated cancer from an unknown primary lesion.Therefore,spinal surgery was performed using the posterior approach to relieve symptoms and verify the diagnosis.Postoperative histologic examination indicated that this poorly differentiated metastatic cancer was possibly sarcomatoid carcinoma.As the patient experienced unexpectedly fast progression of the disease and died 16 d after surgery,the origin of this metastasis was undetermined.We discuss this case with respect to reported perioperative mortality in similar cases.CONCLUSION A comprehensive assessment prior to surgical decision-making is essential to reduce perioperative mortality risk in patients with spinal metastases from an unknown origin. 展开更多
关键词 Hospital mortality SPINE Neoplasm metastasis Unknown primary CARCINOMA Case report
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文章速递青年原发性闭角型青光眼的临床特征 认领
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作者 赵军梅 王琪 《中华眼外伤职业眼病杂志》 2021年第1期44-48,共5页
目的分析青年原发性闭角型青光眼患者的临床特点及治疗效果。方法回顾性分析2009年6月至2019年6月山西省眼科医院17~40岁青年原发性闭角型青光眼51例(61眼)的病历资料,随访时间为6个月至2年。结果本研究中男15例(29.41%),女36例(70.59%)... 目的分析青年原发性闭角型青光眼患者的临床特点及治疗效果。方法回顾性分析2009年6月至2019年6月山西省眼科医院17~40岁青年原发性闭角型青光眼51例(61眼)的病历资料,随访时间为6个月至2年。结果本研究中男15例(29.41%),女36例(70.59%),男女比例为1∶2.4。包括急性闭角型青光眼21眼(34.43%),慢性闭角型青光眼40眼(65.57%)。急性闭角型青光眼患者术后的视力较慢性闭角性青光眼提高且眼压控制明显。虹膜囊肿和瞳孔阻滞在急性闭角型青光眼中发生率高。晶状体厚度及眼轴长度在急性闭角型青光眼患与慢性闭角型青光眼差异无统计学意义,但前房深度慢性闭角型青光眼患者较浅。46眼(75.41%)行小梁切除术,14眼(22.95%)行抗青光眼联合白内障手术,1眼(1.64%)未行手术。术后并发症有前房积血、低眼压、脉络膜脱离、浅前房及睫状环阻塞性青光眼,多发生在慢性闭角型青光眼术后。结论青年闭角型青光眼因解剖因素在治疗时有其特殊性,急性闭角型青光眼常伴有虹膜囊肿,晶状体比较厚,而慢性闭角型青光眼常因为眼轴短,发病隐匿,术后容易引起并发症,尤其是睫状环阻塞性青光眼,治疗效果较差。 展开更多
关键词 青光眼 闭角型 原发性 青年 特征
文章速递急性闭角型青光眼高眼压状态下小梁切除术的远期疗效观察 认领
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作者 叶善文 缪惠子 +1 位作者 张益婷 徐桂花 《中华眼外伤职业眼病杂志》 2021年第1期63-67,共5页
目的观察原发性急性闭角型青光眼患者高眼压状态下行复合式小梁切除术的远期疗效。方法回顾性研究。收集2008年1月至2015年12月惠州市中心人民医院收治的原发性急性闭角型青光眼大发作期患者26例(26眼)的临床资料。所有患者均行局部及... 目的观察原发性急性闭角型青光眼患者高眼压状态下行复合式小梁切除术的远期疗效。方法回顾性研究。收集2008年1月至2015年12月惠州市中心人民医院收治的原发性急性闭角型青光眼大发作期患者26例(26眼)的临床资料。所有患者均行局部及全身降眼压治疗后眼压仍控制欠佳,对急性大发作眼行复合式小梁切除术。术后随访4~11年,观察远期疗效。结果随访期间均未见葡萄膜炎、前房积血或睫状体环阻塞性青光眼等严重并发症。入院眼压为(46.65±18.08)mmHg,出院眼压为(11.58±4.20)mmHg,末次随访眼压为(16.07±10.01)mmHg(1 mmHg=0.133 kPa)。末次随访时滤过泡Ⅰ级者18眼、Ⅱ级者1眼、Ⅲ级者7眼。滤过泡等级与末次随访眼压呈正相关(r=3.350,P=0.009)。随访期间视网膜神经纤维层厚度、视野指数及视野平均偏差逐渐降低(P<0.001)。结论复合式小梁切除术治疗持续性高眼压状态的急性闭角型青光眼患者有效且安全。 展开更多
关键词 青光眼 闭角型 急性 原发性 状态 高眼压 小梁切除术 复合式 疗效 远期
<sup>11</sup>C-Choline PET/CT in the Management of Primary Hyperparathyroidism 认领
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作者 Maria R. Alvarez Rodrigo Arrangoiz +5 位作者 Miguel Á ngel Olarte Cecilia Carreras Maria M. Leó n S. Fernando Cordera 《耳鼻喉(英文)》 2020年第5期149-160,共12页
Primary hyperparathyroidism (PHPT) is a relative common medical problem caused by the inappropriate secretion of parathyroid hormone (PTH) by one or more parathyroid glands. The diagnosis is established by serum calci... Primary hyperparathyroidism (PHPT) is a relative common medical problem caused by the inappropriate secretion of parathyroid hormone (PTH) by one or more parathyroid glands. The diagnosis is established by serum calcium and PTH levels and once the diagnosis is established imaging studies help localize the hyperfunctioning adenoma in preparation for curative surgery. Until now, the imaging studies most commonly utilized in PHPT are ultrasonography and <sup>99m</sup>Tc-Sesta-methoxyisobutylisonitrile (MIBI) parathyroid scintigraphy. However, these studies often fail to localize the adenoma and inappropriately delay patient referral to a potentially curative surgery. We present the case of a 64-year-old female with symptomatic PHPT who had 3 negative <sup>99m</sup>Tc-Sestamibi Scans over a period of 5 years who eventually had a PET/CT with <sup>11</sup>C-Choline that identified a right lower parathyroid adenoma. She underwent a right lower parathyroidectomy and had a successful outcome. We present a review the current imaging techniques used in the management of PHPT including <sup>99m</sup>Tc-Sesta-MIBI scintigraphy and its limitations and novel use of PET/CT with <sup>11</sup>C-Choline and <sup>18</sup>F-Choline in this disease and emphasize the fact that, according to current guidelines, failure to localize the adenoma should not delay referral for curative surgery. 展开更多
关键词 Primary Hyperparathyroidism Evaluation of Primary Hyperparathyroidism 11C-Choline 18F-Fluorocholine PET/CT Treatment of Primary Hyperparathyroidism
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Early Clinical and Functional Outcome of Primary Total Knee Replacement with Posterior Cruciate Substituting Prosthesis for Primary Knee Osteoarthritis Using 2011 Knee Society Score 认领
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作者 Lukman Olalekan Ajiboye Taiwo Afolajuwanlo Adejumobi +2 位作者 Oluwaseyi Kayode Idowu Muhammad Oboirien Suleiman Olatunji Olarewaju 《健康(英文)》 2020年第5期514-522,共9页
Background: Primary knee Osteoarthritis (OA) is the commonest articular disease in middle age and elderly people. Primary total knee replacement (TKR) is a known world-wide standard and definitive treatment of primary... Background: Primary knee Osteoarthritis (OA) is the commonest articular disease in middle age and elderly people. Primary total knee replacement (TKR) is a known world-wide standard and definitive treatment of primary knee OA following failed adequate non-operative management. It is of clinical importance to assess the clinical and functional outcome of TKR to prognosticate the severity of primary knee OA. The new (2011) knee society scoring system (nKSS) is both surgeons and patients’ assessment tool for the treatment outcome of TKR. Study Design: Prospective interventional analytical study. Aim and Objective: The aim of the study was to determine early clinical and functional outcome of primary total knee replacement in patients with primary knee osteoarthritis using nKSS. The objectives were: 1) To determine the pre-operative nKSS and post operative nKSS;2) To determine relationships between pre-operative nKSS and post operative nKSS at 6 weeks, 3, 6, 9 and 12 months;3) To determine the complication rates in patients undergoing primary TKR in the study centre. Methods: A prospective interventional study of 59 patients aged 51 to 70 years who had 67 Total Knee Replacements (TKRs) participated in the study between November 2015 to June 2018 at National Orthopaedics Hospital, Lagos, Nigeria. Patients’ sociodemographic data, pre-operative and post-operative nKSS system were recorded at 6 weeks, 3, 6, 9 and 12 months during follow up. The data were analyzed using Statistical Package for Social Science (SPSS). Results: There were 41 females and 18 males (M:F = 1:2.3). There were total of 67 TKRs with 31 right TKRs, 20 left TKRs and 8 staged bilateral TKRs. The participants’ age ranged from 51 to 70 years with the mean age of 59.5 (±8.5) years. Four patients did not complete the study due to various reasons. The remaining 55 participants completed the study period with progressive improvement of their post-operative nKSS at 6 weeks, 3, 6, 9 and 12 months post-operatively when compared with pre-operative nKSS ( 展开更多
关键词 CLINICAL and Functional Outcome 2011 KNEE SOCIETY SCORE PRIMARY Total KNEE Replacement PRIMARY KNEE Osteoarthritis
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Visual Analysis of Epilepsy Diagnosis Based on Brain Functional Connections 认领
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作者 Yuan Yuan Yuying Zhu +1 位作者 Yu He Yun Zhang 《生物科学与医学(英文)》 2020年第8期149-162,共14页
Epilepsy is a transient neurological disorder associated with changes in the functional connections of the brain. Abnormal electrical discharges can be observed during an epileptic seizure. However, in the absence of ... Epilepsy is a transient neurological disorder associated with changes in the functional connections of the brain. Abnormal electrical discharges can be observed during an epileptic seizure. However, in the absence of an epileptic seizure, the anatomical structure of the brain and the electrical waves of the brain are not observed, making it difficult to explain the cause. This paper deals with together weighted imaging (DWI) sequence data in functional magnetic resonance imaging (FMRI) of epileptic patients before seizure, using Anatomical Automatic Labeling (AAL) template extracted 116 brain regions and the introduction of time series, a matrix of 116 × 116. Pearson correlation coefficient was calculated to investigate the pathological condition of brain function in epilepsy patients, using of neural network visualization system of innovative visual display and compared with the normal epileptic brain function to connect the image, with 38 cases of epilepsy by 187 cases of normal DWI experiment data, and can confirm the existence of brain function in patients with epilepsy connections. Cerebral neural network visualization system showed partial functional connection loss between frontal lobe and temporal lobe in epileptic group compared with normal control group. 展开更多
关键词 Primary Epilepsy FMRI Brain Network Connection Edge Binding Visualization System Diffusion Tensor Imaging
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A Study Protocol on the Evaluation of Referral Strategies for Inflammatory Arthritis in Primary Care Patients at the Level of Healthcare Organization, Patient Relevant Outcomes and Costs 认领
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作者 Elke Theodora Antonia Maria van Delft Deirisa Lopes Barreto +5 位作者 Jan Arno Matteo Roeterink Khik Hoo Han Ilja Tchetverikov Anna Helena Maria van der Helm-van Mil Johanna Maria Wilhelmina Hazes Angelique Elisabeth Adriana Maria Weel 《健康(英文)》 2020年第3期240-252,共13页
Background: Considering the importance of getting the right patient at the right location to maintain and optimize quality of life of inflammatory arthritis patients, appropriate referral by general practitioners is e... Background: Considering the importance of getting the right patient at the right location to maintain and optimize quality of life of inflammatory arthritis patients, appropriate referral by general practitioners is essential. This study aims to assess the effect and cost effectiveness of different referral strategies for inflammatory arthritis in primary care patients. Methods: This study follows a cluster randomized controlled trial design. General practitioners from primary care centers in Southwest-The Netherlands are randomly assigned to either one of the two strategic interventions for referring adult patients who are in the opinion of the general practitioner suspected of inflammatory arthritis: 1) Standardized digital referral algorithm based on existing referral models PEST, CaFaSpA and CARE;2) Triage by a rheumatologist in the local primary care center. These interventions will be compared to a control group, e.g. usual care. The primary outcome is the percentage of patients diagnosed with inflammatory arthritis by the rheumatologist. Secondary outcomes are quality of life as a patient reported outcome, work participation and healthcare costs. These data, including demographic and clinical parameters, are prospectively collected at baseline, three, six, and twelve months. Discussion: If this study can demonstrate improvements in appropriate referrals to the rheumatologist, thereby improving cost-effectiveness, there is sufficient supporting evidence to implement one of the referral strategies as a standard of care. Finally, with these optimization strategies a higher quality of care can be achieved, that might be of value for all patients with arthralgia. Trial Registration: NCT03454438, date of registration: March 5, 2018. Retrospectively registered: https://clinicaltrials.gov/ct2/show/NCT03454438?term=NCT03454438&draw=1&rank=1. 展开更多
关键词 Inflammatory ARTHRITIS Primary CARE REFERRAL COST-EFFECTIVENESS Cluster Randomized Trial Value Based Health CARE
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The Epidemiological, Clinical, Biological and Morphological Characteristics of Primitive Liver Cancers in Bangui 认领
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作者 Serges Magloire Camengo Police Georges Service +13 位作者 Nathalie Philomè ne Boua-Akelelo Diane N’guilé Benoî t Elowa Timothé e Mobima Francky Kouandogui Bangué Eveline Mofini Yangba Kalebanga Armelo Thibaut Bessanguem Bernard Boniface Koffi 《肠胃病学期刊(英文)》 2020年第4期97-105,共9页
Objective: To describe the epidemiological, clinical, biological and morphological aspects of primary liver cancer (PLC). Patients and Methods: We conducted a 38-month cross-sectional study in the Department of hepato... Objective: To describe the epidemiological, clinical, biological and morphological aspects of primary liver cancer (PLC). Patients and Methods: We conducted a 38-month cross-sectional study in the Department of hepatogas-troenterology and Internal Medicine “Amitié Sino-Centrafraine” University Hospital Center in Bangui. Included in the study were all patients with a diagnosis of PLC. The PLC’s diagnostic arguments were the large tumor liver associated or not with the elevation of alpha-fetoprotein, the heteronodular liver hypervascularized on abdominal ultrasound. Data analysis was done using Epi Info 3.5.1 software. Results: We collected 115 cases of CPF among 2410 hospitalized patients (4.7%). There were 86 men and 29 women (sex ratio: 2.9). The average age was 50 years old. The main risk factors were alcohol consumption (72.2%) and chronic hepatitis B infection (67.4%). Frequent clinical signs were pain in the right hypochondrium and/or epigastric (93.86%), large tumor liver under examination (91.3%), weight loss (74.78%). The serum alpha-fetoprotein concentration was ≥ 400 ng/ml in 73% of the cases. The abdominal ultrasound found a heteronodular liver in all patients. The nodules were multiple hyperechoic in 66.1% of the cases. According to the Child-Pugh classification, the patients were classified as B (49.5%) and C (33.9%). The Okuda Classification ranked patients at stage 1 in 16.5% cases, stage 2 in 52.1% cases and stage 3 in 31.3% cases. According to the BCLC classification, 5.2% of patients were in stage A, 12.2% in stage B, 52.2 in stage C and 30.4% in stage D. Death was recorded during hospitalization in 89 cases (77.4%). Conclusion: CPF is a frequent and serious pathology in Bangui. Its diagnosis is often late, preventing curative treatment. The main causes are alcohol consumption and the hepatitis B virus. The population should be educated to reduce the incidence of this disease. 展开更多
关键词 Primary Liver Cancer EPIDEMIOLOGY CLINICAL MORPHOLOGY Bangui
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Impact of Smoking Status on Hospital Outcome of Patients with ST-Segment Elevation Myocardial Infarction Either Treated by Pharmaco-Invasive Strategy or Primary Percutaneous Coronary Intervention 认领
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作者 Ahmed F. Alaarag Mahmoud A. Abouomar Timoor M. Hassan 《心血管病(英文)》 2020年第6期347-356,共10页
<strong>Introduction:</strong> <span style="font-family:Verdana;">Smoking is a common public problem with a high health burden. Many studies have shown that there are many hazardous actions... <strong>Introduction:</strong> <span style="font-family:Verdana;">Smoking is a common public problem with a high health burden. Many studies have shown that there are many hazardous actions of smoking on body systems especially haemostatic, respiratory and circulatory systems.</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">Smoking may increase the thrombus burden in patients with acute coronary syndrome. The </span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">smoker’s paradox</span><span style="font-family:Verdana;">”</span><span style="font-family:Verdana;"> has been described for more than 25 years. Its existence and its effect on patients’ outcome post-myocardial infarction are debatable</span><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;"><b>Methods: </b></span><span style="font-family:Verdana;">Our prospective observational study was conducted from-August 2018 to August 2019 on STEMI patients with the duration from onset of symptoms to first medical contact were 12 hours or less. We included 199 patients in our study.</span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">Patients are divided into 4 groups </span><b><i><u><span style="font-family:Verdana;">Group </span></u></i><u><span style="font-family:Verdana;">1</span></u></b></span><span style="font-family:Verdana;"><b> </b></span><span style="font-family:;" "=""><span style="font-family:Verdana;">(Smokers treated by PPCI) </span><b><i><u><span style="font-family:Verdana;">Group </span></u></i><u><span style="font-family:Verdana;">2</span></u></b><span style="font-family:Verdana;"> (Non-smokers treated by</span></span><span style="font-family:;" "=""><span style="font-family:Verdana;"> PPCI) </span><b><i><u><span style="font-family:Verdana;">Group </span></u></i><u><span style="font-family:Verdana;">3</span></u></b><span style="font-family:Verdana;"> (Smoker treated by pharmaco-inva 展开更多
关键词 Smoker Paradox STEMI Primary PCI Pharmaco-Invasive Strategy
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Percutaneous Coronary Intervention for a Pregnant Woman with Acute ST Elevation Myocardial Infarction: A Case Report 认领
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作者 Farouk Boukerche Adam Ahamat Ali +1 位作者 Nadia Laredj Leila Hammou 《心血管病(英文)》 2020年第6期357-362,共6页
Acute myocardial infarction in women during childbearing age is rare. We report a case of a 40-year-old female patient with no history or cardiovascular risk factors, 24-week</span><span style="font-fami... Acute myocardial infarction in women during childbearing age is rare. We report a case of a 40-year-old female patient with no history or cardiovascular risk factors, 24-week</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">pregnant who presented with acute coronary syndrome with an ST-elevation anterior extended complicated by cardiogenic shock. Cardiac ultrasound showed systolic dysfunction of the left ventricle at 30%. Emergency coronary angiography revealed subocclusion of the proximal anterior interventricular artery. We performed a primary angioplasty with placement of a stent after balloon predilation with a satisfactory agiographic result and an improvement in the hemodynamic state. The patient gave birth by cesarean section at 30 weeks of pregnancy after a pocket rupture of infectious waters. The newborn died after 72 hours. After 6 years of evolution, the patient remained asymptomatic under medal treatment. 展开更多
关键词 PREGNANCY Acute Coronary Syndrome Primary Angioplasty Oran-Algeria
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