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Chemistry of two-dimensional MXene nanosheets in theranostic nanomedicine 认领
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作者 Yuemei Wang Wei Feng Yu Chen 《中国化学快报:英文版》 SCIE CAS CSCD 2020年第4期937-946,共10页
Transition metal carbide,carbonitride and nitride MXenes,as the emerging two-dimensional(2D)nanomaterials,have aroused burgeoning research interest in a broad range of applications ranging from energy conversion to bi... Transition metal carbide,carbonitride and nitride MXenes,as the emerging two-dimensional(2D)nanomaterials,have aroused burgeoning research interest in a broad range of applications ranging from energy conversion to biomedicines attributing to their distinctive planar nanostructure,physiochemical properties and biological effects.They are featured with fascinating electronic,optical,magnetic,mechanical and thermal properties,which exert significant roles in biomedical applications of 2D MXenes.In this review,we briefly summarize the recent research progress of 2D MXenes and highlight their intrinsic chemistry in theranostic nanomedicines,focusing on the synthetic chemistry for MXenes construction,surface chemistry for surface engineering,physiochemical property for theranostic application and biological chemistry for biosafety evaluation.Furthermore,based on the current achieve ments on MXenes,their potential research directio n,critical challenges and future development in biomedicine are also discussed.It is highly expected that 2D MXene-based nanosystems would have a broad application prospect in theranostic biomedicine provided the current facing critical issues and challenges are adequately solved. 展开更多
关键词 MXenes Two-dimensional materials NANOMEDICINE CANCER THERANOSTIC
铁死亡诱导型纳米药物的构建及抗肿瘤研究进展 认领
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作者 李超群 汤红霞 +3 位作者 张悦 宋倩倩 陈凤英 费伟东 《药学学报》 CAS CSCD 北大核心 2020年第9期2099-2109,共11页
铁死亡是一种铁依赖性活性氧异常堆积而导致氧化还原平稳失调的细胞死亡方式。作为一种新的癌症治疗途径,铁死亡引起了研究者的广泛关注。随着纳米科学的迅速发展,多样化的功能性纳米材料能够发挥生成过氧化氢,清除谷胱甘肽,以及提供芬... 铁死亡是一种铁依赖性活性氧异常堆积而导致氧化还原平稳失调的细胞死亡方式。作为一种新的癌症治疗途径,铁死亡引起了研究者的广泛关注。随着纳米科学的迅速发展,多样化的功能性纳米材料能够发挥生成过氧化氢,清除谷胱甘肽,以及提供芬顿反应催化剂等作用,因此能够协同所负载的铁死亡诱导药物而发挥出更加强大的肿瘤抑制作用。本文首先介绍了铁死亡的发生机制及铁死亡诱导策略在肿瘤治疗中的可行性。其次,概述了铁死亡诱导型纳米药物的构建思路,主要包括:加速细胞内芬顿反应、抑制谷胱甘肽过氧化物酶4的活性及增加脂质过氧化物的外源递送。此外,本文还总结了基于铁死亡的联合疗法,包括与传统疗法的联合治疗(联合凋亡诱导药物、免疫治疗与基因治疗)以及体外能量协同诱导铁死亡治疗(包括超声治疗及光动力治疗)。最后,本文讨论了未来诱导铁死亡纳米药物在癌症治疗中的期望和挑战。 展开更多
关键词 铁死亡 纳米药物 活性氧 谷胱甘肽过氧化物酶4 联合治疗
活性氧簇响应型纳米药物对活体小鼠角膜新生血管形成抑制作用的评估 认领
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作者 刘安琪 梁春菁 +2 位作者 汪铭 王丽强 黄一飞 《中华实验眼科杂志》 CAS CSCD 北大核心 2020年第2期85-92,共8页
目的评估活性氧簇(ROS)响应型纳米药物对活体小鼠角膜新生血管(CNV)形成的影响。方法Michael加成反应合成含有缩硫酮键的载血管内皮生长因子小干扰RNA(siVEGF)的ROS响应型纳米药物(ROS-TK-5/siVEGF)。琼脂糖凝胶电泳测定纳米药物在高RO... 目的评估活性氧簇(ROS)响应型纳米药物对活体小鼠角膜新生血管(CNV)形成的影响。方法Michael加成反应合成含有缩硫酮键的载血管内皮生长因子小干扰RNA(siVEGF)的ROS响应型纳米药物(ROS-TK-5/siVEGF)。琼脂糖凝胶电泳测定纳米药物在高ROS环境中的siVEGF累计释放量。选取39只6~8周龄VEGFR2-luc-KI转基因荧光标记小鼠,采用随机数字表法将其中30只小鼠分为正常对照组、PBS对照组、ROS-TK-5/NC组、ROS-TK-5/siVEGF组和雷珠单抗组,每组6只,采用NaOH滤纸贴附角膜中央的方法构建小鼠右眼CNV模型,正常对照组不做处理;应用随机数字表法将另外9只小鼠分为正常对照组、建模后7 d组和建模后14 d组,每组3只小鼠,采用二氢乙啶(DHE)染色法测定小鼠角膜碱烧伤后角膜组织内ROS含量。裂隙灯显微镜眼前节照相与小动物活体成像系统(IVIS)观察小鼠角膜碱烧伤后7、14、21 d应用纳米药物对CNV形成的影响。结果在无ROS环境中,仅5%~10%的siVEGF从纳米复合物中释放出。与10 mmol/L H2O2共孵育10 h后,约70%的siVEGF从纳米药物中释放。建模后7 d和14 d,角膜基质层相对荧光强度分别为5.403±0.306和2.930±0.255,较正常对照组的1.003±0.015明显增加,差异均有统计学意义(均P<0.05)。各组建模后不同时间CNV面积比较,差异均有统计学意义(F分组=49.855,P<0.01;F时间=65.556,P<0.01),其中建模后7 d和14 d,ROS-TK-5/siVEGF组和雷珠单抗组的CNV面积较PBS对照组和ROS-TK-5/NC组明显减小,ROS-TK-5/siVEGF组CNV面积较雷珠单抗组明显减小,差异均有统计学意义(均P<0.05);建模后21 d,ROS-TK-5/siVEGF组和雷珠单抗组的CNV面积较PBS对照组及ROS-TK-5/NC组明显减小,差异均有统计学意义(均P<0.05)。各组小鼠建模后不同时间小鼠角膜的荧光信号强度比较,差异均有统计学意义(F分组=27.193,P=0.003;F时间=51.062,P<0.01),其中建模后7 d和14 d,ROS-TK-5/siVEGF组和雷珠单抗组的角膜荧光信号强 展开更多
关键词 活体成像系统 碱烧伤 角膜新生血管 活性氧簇 纳米药物
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特异性骨靶向纳米递药系统的优势与临床可应用性 认领
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作者 向海滨 李新霞 +1 位作者 梁求真 宋兴华 《中国组织工程研究》 CAS 北大核心 2020年第4期612-618,共7页
背景:在骨相关疾病治疗中特异性主动靶向递药系统非常重要,而纳米技术的发展为其提供了良好的平台,同时为其提供了新的研究思路。目的:针对以特异性骨靶向递药系统的目前发展及未来前景做一综述。方法:应用计算机在Pub Med、Web of Scie... 背景:在骨相关疾病治疗中特异性主动靶向递药系统非常重要,而纳米技术的发展为其提供了良好的平台,同时为其提供了新的研究思路。目的:针对以特异性骨靶向递药系统的目前发展及未来前景做一综述。方法:应用计算机在Pub Med、Web of Science和Medline等数据库检索涉及主动骨靶向性递药系统与纳米级递药系统的相关研究,检索关键词为"Bone target therapy,Nanoparticles,Drug delivery system",检索时间为2014年3月至2019年3月。结果与结论:靶向基团是特异性骨靶向递药系统的重要组成部分,它决定了递药系统的靶向效率。到目前为止已发现针对于骨组织、破骨细胞、成骨细胞、骨髓间充质干细胞的靶向分子,它们有各自优缺点。目前特异性骨靶向纳米递药系统已在各种骨病领域得到了广泛研究,如转移骨质疏松症、骨髓炎、多发性骨髓瘤、骨肉瘤、骨转移癌等。纳米载体应用的优势为其带来了临床潜力的同时也存在许多挑战,尽管许多基础研究显示出很好的体内结果,但很少有骨靶向基团修饰的纳米递药系统成功地将其转化为临床。 展开更多
关键词 靶向药物 药物递送系统 纳米医学 骨靶向治疗 靶向分子 骨骼疾病 纳米粒 特异性
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Inhibition of Wnt signaling by Frizzled7 antibody-coated nanoshells sensitizes triple-negative breast cancer cells to the autophagy regulator chloroquine 认领
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作者 Jianxin Wang Megan N.Dang Emily S.Day 《纳米研究:英文版》 SCIE EI CAS CSCD 2020年第6期1693-1703,共11页
Nano Research volume 13,pages1693–1703(2020)Cite this article 137 Accesses 6 Altmetric Metrics details Abstract Despite improvements in our understanding of the biology behind triple-negative breast cancer(TNBC),it r... Nano Research volume 13,pages1693–1703(2020)Cite this article 137 Accesses 6 Altmetric Metrics details Abstract Despite improvements in our understanding of the biology behind triple-negative breast cancer(TNBC),it remains a devastating disease due to lack of an effective targeted therapy.Inhibiting Wnt signaling is a promising strategy to combat TNBC because Wnt signaling drives TNBC progression,chemoresistance,and stemness.However,Wnt inhibition can lead to upregulation of autophagy,which confers therapeutic resistance.This provides an opportunity for combination therapy,as autophagy inhibitors applied concurrently with Wnt inhibitors could increase treatment efficacy.Here,we applied the autophagy inhibitor chloroquine(CQ)to TNBC cells in combination with Frizzled7 antibody-coated nanoshells(FZD7-NS)that suppress Wnt signaling by blocking Wnt ligand/FZD7 receptor interactions,and evaluated this dual treatment in vitro.We found that FZD7-NS can inhibit Axin2 and CyclinD1,two targets of canonical Wnt signaling,and increase the expression of LC3,an autophagy marker.When FZD7-NS and CQ are applied together,they reduce the expression of several stemness genes in TNBC cells,leading to inhibition of TNBC cell migration and self-renewal.Notably,co-delivery of FZD7-NS and CQ is more effective than either therapy alone or the combination of CQ with free FZD7 antibodies.This demonstrates that the nanocarrier design is important to its therapeutic utility.Overall,these findings indicate that combined regulation of Wnt signaling and autophagy by FZD7-NS and CQ is a promising strategy to combat TNBC. 展开更多
关键词 NANOMEDICINE nanoparticles combination therapy antibody delivery cancer stem cells
Nanodiamonds with powerful ability for drug delivery and biomedical applications:Recent updates on in vivo study and patents 认领
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作者 Swati Chauhan Neha Jain Upendra Nagaich 《药物分析学报:英文版》 SCIE CAS CSCD 2020年第1期1-12,共12页
Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical application.The... Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical application.These are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical era.Alongside,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with nanodiamonds.Surface modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface chemistry.To take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological environment.This review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of nanodiamonds.For the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces. 展开更多
关键词 NANOMEDICINE BIOCHEMICAL application Diamondoids Surface FUNCTIONALIZATION Drug targeting
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纳米药物的研究进展 认领
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作者 刘君 许银银 +1 位作者 李萌 钱海 《药学与临床研究》 2020年第1期51-55,共5页
纳米药物为各种重大疾病提供了新的诊断和治疗手段,其临床应用和工业化研究也越来越受到关注,目前有关纳米药物研究的指导性法规尚无系统而完整的条款,尤其纳米药物的工业化生产没有统一规律可循,且目前市场上的产品种类较少。本文拟就... 纳米药物为各种重大疾病提供了新的诊断和治疗手段,其临床应用和工业化研究也越来越受到关注,目前有关纳米药物研究的指导性法规尚无系统而完整的条款,尤其纳米药物的工业化生产没有统一规律可循,且目前市场上的产品种类较少。本文拟就纳米药物的分类及研发进展、制备方法、评价指标等方面作一综述。 展开更多
关键词 纳米药物 制备方法 评价指标 工业化
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Recent Advances of D-α-tocopherol Polyethylene Glycol 1000 Succinate Based Stimuli-responsive Nanomedicine for Cancer Treatment 认领
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作者 Yang GUAN Lin-yan WANG +3 位作者 Bo WANG Mei-bong DING Yu-ling BAO Song-wei TAN 《当代医学科学(英文)》 SCIE CAS 2020年第2期218-231,共14页
D-a-tocopherol polyethylene glycol 1000 succinate(TPGS)is a pharmaceutical excipient approved by Chinese NMPA and FDA of USA.It's widely applied as a multifunctional drug carrier for nanomedicine.The advantages of... D-a-tocopherol polyethylene glycol 1000 succinate(TPGS)is a pharmaceutical excipient approved by Chinese NMPA and FDA of USA.It's widely applied as a multifunctional drug carrier for nanomedicine.The advantages of TPGS include P-glycoprotein(P-gp)inhibition,penetration promotion,apoptosis induction via mitochondrial-associated apoptotic pathways,multidrug resistant(MDR)reversion,metastasis inhibition and so on.TPGS-based drug delivery systems which are responding to extermal stimulus can combine the inhibitory functions of TPGS towards P-gp with the environmentally responsive controlled release property and thus exerts a synergistic anti-cancer effect,through increased intracellular drug concentration in tumors cells and well-controlled drug release behavior.In this review,TPGS-based nano-sized delivery systems responsive to different stimuli were summarized and discussed,including pH-responsive,redox-responsive and multi-responsive systems in various formulations.The achievements,mechanisms and diffcrent characteristics of TPGS-bascd stimuli-responsive drug-delivery systems in tumor therapy were also outlined. 展开更多
关键词 D-a-tocopherol polyethylene glycol 1000 succinate STIMULI-RESPONSIVE NANOMEDICINE P-GLYCOPROTEIN cancer
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口腔鳞癌叶酸表达的临床病理分析 认领
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作者 杨艳 陈盛 +1 位作者 蒲玉梅 王育新 《实用口腔医学杂志》 CAS CSCD 北大核心 2020年第5期799-803,共5页
目的:观察口腔鳞状细胞癌(OSCC)中叶酸受体(FRα)的表达水平及其与肿瘤临床病理的关系。方法:免疫组化方法分析95例OSCC患者FRα表达情况,分析其与临床参数、总生存率(OS)和无病生存率(DFS)的相关性。结果:95例OSCC组织FRα中、高表达占... 目的:观察口腔鳞状细胞癌(OSCC)中叶酸受体(FRα)的表达水平及其与肿瘤临床病理的关系。方法:免疫组化方法分析95例OSCC患者FRα表达情况,分析其与临床参数、总生存率(OS)和无病生存率(DFS)的相关性。结果:95例OSCC组织FRα中、高表达占57.9%。5年OS,FRα高、中、低表达者分别为33.4%、79.4%、90.1%(P=0.0003);5年DFS在FRα高、中、低表达患者中分别为44.7%、82.9%、69.5%(P=0.0336)。FRα表达与OSCC的肿瘤浸润方式、淋巴结转移、肿瘤分期密切相关,FRα高表达与OS和DFS负相关(P<0.05)。结论:FRα表达与OSCC临床病理进展相关。 展开更多
关键词 口腔鳞癌 叶酸 纳米医学 临床病理分析 靶向治疗
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Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy 认领
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作者 Jialing Hu Fuan Wang +5 位作者 Feng Liu Wentong Sun Qunying Jiang Yahua Liu Yun Zhao Xiaoqing Liu 《纳米研究:英文版》 SCIE EI CAS CSCD 2020年第4期1111-1121,共11页
Metastasis remains the primary cause for mortality of breast cancer.Despite advances in current therapeutic agents,patients with metastatic breast cancer still have poor prognoses.Tumor hypoxia,a key microenvironment ... Metastasis remains the primary cause for mortality of breast cancer.Despite advances in current therapeutic agents,patients with metastatic breast cancer still have poor prognoses.Tumor hypoxia,a key microenvironment factor,is emerging as an attractive target to prevent metastasis and is also involved with resistance to phototherapy.Here,we show an effective nanotherapeutic approach based on manganese dioxide-coated polydopamine nanocarriers to trigger robust anti-tumor and anti-metastasis responses against metastatic breast cancer by supplemental oxygenation and multimodal imaging-guided phototherapies.In cancer cells,the produced oxygen by the developed nanoplatform decreases the expression of hypoxia-inducible factors 1 a to inhibit tumor metastasis,and enhances the efficacy of photodynamic therapy.This nanotherapeutic approach enables the combined photodynamic/photothermal treatments with great inhibition on cell migration and invasion in vitro.Moreover,the nanotherapeutics effectively suppresses primary tumor progress and inhibits lung metastasis in v ivo in a breast cancer mouse model with satisfying biosafety.This study suggests that the tumor hypoxia-targeting nanotherapeutics have great potential for preventing and treating metastatic cancers. 展开更多
关键词 NANOMEDICINE HYPOXIA breast cancer metastasis supplemental oxygenation PHOTOTHERAPY
聚合物分子刷在纳米载体领域的应用 认领
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作者 孙子扬 李华安 +2 位作者 黄华华 石毅 陈永明 《高分子学报》 SCIE CAS CSCD 北大核心 2020年第6期609-619,I0004,共12页
聚合物分子刷是一种通过共价键连接的单分子纳米材料,与通过超分子自组装获得的纳米组装体相比,其在复杂的生理环境中具有更好的循环稳定性.另外,可以通过调控聚合物分子刷主链与侧链的相对长度,即调控长径比,获得类似于球状、棒状、蠕... 聚合物分子刷是一种通过共价键连接的单分子纳米材料,与通过超分子自组装获得的纳米组装体相比,其在复杂的生理环境中具有更好的循环稳定性.另外,可以通过调控聚合物分子刷主链与侧链的相对长度,即调控长径比,获得类似于球状、棒状、蠕虫状的纳米颗粒,为研究具有相同化学组成不同形貌的纳米颗粒的生理行为提供了研究平台.因此,本文总结了近十年来聚合物分子刷在小分子药物输送、基因负载、生物成像等纳米医学领域的相关研究进展,并展望了聚合物分子刷在纳米医学领域的发展前景. 展开更多
关键词 聚合物分子刷 单分子纳米颗粒 纳米医学 纳米载药系统 生物成像
纳米药物国际研究态势分析 认领
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作者 王宇斐 马嘉虹 梁兴杰 《中国科学:生命科学》 CSCD 北大核心 2020年第7期698-714,共17页
随着纳米技术的不断发展,纳米药物成为21世纪医药领域的前沿热点.智能化的纳米药物有望突破传统药物的技术瓶颈,以更高的疗效、更低的毒副反应、更灵活的用药方式为多种重大恶性疾病的治疗提供可能.本文检索了2008~2018年内有关纳米药... 随着纳米技术的不断发展,纳米药物成为21世纪医药领域的前沿热点.智能化的纳米药物有望突破传统药物的技术瓶颈,以更高的疗效、更低的毒副反应、更灵活的用药方式为多种重大恶性疾病的治疗提供可能.本文检索了2008~2018年内有关纳米药物的研究论文专利,并对该领域的国际研究态势进行了分析. 展开更多
关键词 纳米药物 纳米医学 态势分析
Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics 认领
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作者 Simon Van Herck Bruno G.De Geest 《中国药理学报:英文版》 SCIE CAS CSCD 2020年第7期881-894,共14页
The advent of immunotherapy is a game changer in cancer therapy with monoclonal antibody-and T cell-based therapeutics being the current flagships.Small molecule immunotherapeutics might offer advantages over the biol... The advent of immunotherapy is a game changer in cancer therapy with monoclonal antibody-and T cell-based therapeutics being the current flagships.Small molecule immunotherapeutics might offer advantages over the biological drugs in terms of complexity,tissue penetration,manufacturing cost,stability,and shelf life.However,small molecule drugs are prone to rapid systemic distribution,which might induce severe off-target side effects.Nanotechnology could aid in the formulation of the drug molecules to improve their delivery to specific immune cell subsets.In this review we summarize the current efforts in changing the pharmacokinetic profile of small molecule immunotherapeutics with a strong focus on Toll-like receptor agonists.In addition,we give our vision on limitations and future pathways in the route of nanomedicine to the clinical practice. 展开更多
关键词 cancer immunotherapy small molecule drugs pharmacokinetic profile NANOMEDICINE toll-like receptors stimulator of interferon genes(STING)
纳米诊疗研究进展 认领
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作者 马明 武昊安 +3 位作者 白晨 陈玲 张宇 顾宁 《中国科学:生命科学》 CSCD 北大核心 2020年第7期734-754,共21页
为了实现肿瘤的个体化精准医疗,"纳米诊疗"领域应运而生.本文介绍了纳米诊疗领域发展过程中重要进展的时间线,详细分析了该领域研究论文发表情况,包括论文发表数量、主要研究机构、主要支持基金以及重要杂志等,并进一步详细... 为了实现肿瘤的个体化精准医疗,"纳米诊疗"领域应运而生.本文介绍了纳米诊疗领域发展过程中重要进展的时间线,详细分析了该领域研究论文发表情况,包括论文发表数量、主要研究机构、主要支持基金以及重要杂志等,并进一步详细综述了纳米诊疗平台的构建策略和重要研究进展.纳米诊疗平台的构建策略是将靶向递送、诊断和治疗功能结合在同一个纳米载体上,这种纳米载体可以是聚合物纳米颗粒、脂质体纳米颗粒或是无机纳米颗粒,以实现多种成像模式联合诊断,多种治疗方法协同治疗,以及诊疗一体化等独特功能.纳米诊疗剂通向临床之路困难重重,但精准医疗是未来医学发展的大趋势,诊疗纳米颗粒的临床使用和研究必然具有巨大的发展潜力. 展开更多
关键词 纳米诊疗 纳米颗粒 肿瘤治疗 精准医疗 纳米药物 成像
Nanoengineered targeting strategy for cancer immunotherapy 认领
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作者 Wei-min Yin Yu-wei Li +1 位作者 Yun-qing Gu Min Luo 《中国药理学报:英文版》 SCIE CAS CSCD 2020年第7期902-910,共9页
Cancer immunotherapy is rapidly changing the paradigm of cancer care and treatment by evoking host immunity to kill cancer cells.As clinical approval of checkpoint inhibitors(e.g.,ipilimumab and pembrolizumab)has been... Cancer immunotherapy is rapidly changing the paradigm of cancer care and treatment by evoking host immunity to kill cancer cells.As clinical approval of checkpoint inhibitors(e.g.,ipilimumab and pembrolizumab)has been accelerated by a dramatic improvement of long-term survival in a small subset of patients compared to conventional chemotherapy,growing interesting research has focused on immunotherapy.However,majority of patients have not benefited from checkpoint therapies that only partially remove the inhibition of T cell functions.Insufficient systemic T cell responses,low immunogenicity and the immunosuppressive environment of tumors,create great challenges on therapeutic efficiency.Nanotechnology can integrate multiple functions within controlled size and shape,and has been explored as a unique avenue for the development of cancer immunotherapy.In this review,we mainly address how nanoengineered vaccines can induce robust T cell responses against tumors,as well as how nanomedicine can remodel the tumor immunosuppressive microenvironment to boost antitumor immune responses. 展开更多
关键词 cancer immunotherapy NANOMEDICINE cancer vaccine immune resistance NANOVACCINE immunosuppressive microenvironment
γ⁃Fe2O3@carboxymethyl Cellulose as Potential Oral Nanomedicine for Iron Deficiency Anemia Treatment on Rats 认领
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作者 Bo Chen Peng Zhao +6 位作者 Qiwei Wang Zhanhang Guo Xin Liu Yan Li Yue Zhang Min Ji Ning Gu 《哈尔滨工业大学学报:英文版》 EI CAS 2020年第3期158-169,共12页
Oral iron supplements such as ferrous iron salts are major treatment agents for iron deficiency anemia(IDA)due to the convenience of large dose administration and good patient compliance.However,the gastrointestinal a... Oral iron supplements such as ferrous iron salts are major treatment agents for iron deficiency anemia(IDA)due to the convenience of large dose administration and good patient compliance.However,the gastrointestinal adverse impact caused by Fe2+stimulus and low bioavailability severely impedes its therapeutic effects.In recent years,it has been found that nano iron⁃based nanoparticles with high surface⁃to⁃volume ratio and low iron ion leakage can alleviate the toxic effect and improve the gastrointestinal absorbance.For further clinical development,nano materials need to meet the pharmaceutical quality demand.Carboxymethyl cellulose(CMC)is a significant pharmaceutical ingredient applied in approved drug formulations,and polyglucosorbitol carboxymethylether(PSC)has been utilized in iron⁃based nanomedicine ferumoxytol synthesis,both of which can be firmly anchored on iron oxide by carboxyl chelation.In this work,iron oxide nanoparticles(NPs)modified with CMC were designed and synthesized,and the structure composition and physicochemical properties were distinctly characterized.Oral supplement effects on rat IDA were investigated and compared with other recently reported iron supplements including NPs modified with PSC.Results show that the oral nano iron supplement achieved the recovery of hemoglobin and serum iron level in only two weeks with high safety.The nano iron oxide modified with pharmaceutical excipients provides new potential approach for oral iron supplement available in clinics. 展开更多
关键词 iron oxide nanomedicine carboxymethyl cellulose polyglucosorbitol carboxymethylether oral agent iron deficiency anemia
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Strategies for engineering advanced nanomedicines for gas therapy of cancer 认领
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作者 Yingshuai Wang Tian Yang Qianjun He 《国家科学评论:英文版》 SCIE EI CSCD 2020年第9期1485-1512,共28页
As an emerging and promising treatment method,gas therapy has attracted more and more attention for treatment of inflammation-related diseases,especially cancer.However,therapeutic/therapy-assisted gases(NO,CO,HgS,H2,... As an emerging and promising treatment method,gas therapy has attracted more and more attention for treatment of inflammation-related diseases,especially cancer.However,therapeutic/therapy-assisted gases(NO,CO,HgS,H2,O2,SO and CO2)and most of their prodrugs lack the abilities of active intratumoral accumulation and controlled gas release,resulting in limited cancer therapy efficacy and potential side effects.Therefore,development of nanomedicines to realize tumor-targeted and controlled release of therapeutic/therapy-assisted gases is greatly desired,and also the combination of other therapeutic modes with gas therapy by multifunctional nanocarrier platforms can augment cancer therapy efficacy and also ced gas-releasingnanomedicines from four aspects:(1)stimuli-responsive strategies for controlled gas release;multi-model combination strategies based on gas therapy.Moreover,we highlight current issues and gaps in knowledge,and envisage current trends and future prospects of advanced nanomedicines for gas therapy of cancer.This review aims to inspire and guide the engineering of advanced gas-releasing nanomedicines.reduce their side effects.The design ofnanomedicines with these functions is vitally important,but challenging.In this review,we summarize a series of engineering strategies for construction of advar(2)catalytic strategies for controlled gas release;(3)tumor-targeted gas delivery strategies;(4) 展开更多
关键词 NANOMEDICINE gas therapy drug delivery controlled release cancer treatment
The blooming intersection of transcatheter hepatic artery chemoembolization and nanomedicine 认领
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作者 Hu Chen Hongwei Cheng +4 位作者 Wenying Wu Dengfeng Li Jingsong Mao Chengchao Chu Gang Liu 《中国化学快报:英文版》 SCIE CAS CSCD 2020年第6期1375-1381,F0003,共8页
Transcatheter hepatic artery chemoembolization(TACE)is a universal treatment for patients with hepatocellular carcinoma(HCC)that inhibits tumor growth by cutting off the blood supply and provides chemotherapeutics loc... Transcatheter hepatic artery chemoembolization(TACE)is a universal treatment for patients with hepatocellular carcinoma(HCC)that inhibits tumor growth by cutting off the blood supply and provides chemotherapeutics locally to the tumor.The strategy of combining TACE formulation with image-guided ablation holds tremendous potential,but patient tolerance and undesired toxicity/immunosuppression remains a challenge.The application of nanotechnology in TACE opens new doors for the treatment of HCC.Strikingly,nanomaterials or nano-drugs dispersed in the TACE formulation can effectively improve the delivery efficiency of drugs by achieving both controlled and continuous release.In addition,the utilization of multifunctional nanoparticles can provide guidance and monitoring for various advanced imaging methods for TACE treatment,and can realize the combination therapy of thermal ablation,microwave ablation,in situ radiotherapy,and other therapies,greatly expanding the therapeutic strategies available for HCC treatment.Here,the current exploration of nanotechnology in TACE of HCC is briefly summarized and the challenges of TACE with nanoformulations for clinical translation are comprehensively discussed. 展开更多
关键词 Transcatheter hepatic artery CHEMOEMBOLIZATION Hepatocellular carcinoma NANOMEDICINE THERANOSTICS Combination therapy
肿瘤微环境响应的仿生金属纳米粒用于光动力学治疗的研究 认领
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作者 郑蓉蓉 赵林平 +2 位作者 陈华清 李仕颖 余细勇 《药学学报》 CAS CSCD 北大核心 2020年第7期1672-1679,共8页
本文基于生物配位化合物和仿生金属蛋白的概念,将组氨酸修饰的光敏剂功能化序列与锌离子配位,形成仿生金属纳米粒(nanoparticles,NPs)。NPs在高谷胱甘肽(glutathione,GSH)和低pH值的肿瘤微环境条件下可被降解释放,进而实现肿瘤光动力学... 本文基于生物配位化合物和仿生金属蛋白的概念,将组氨酸修饰的光敏剂功能化序列与锌离子配位,形成仿生金属纳米粒(nanoparticles,NPs)。NPs在高谷胱甘肽(glutathione,GSH)和低pH值的肿瘤微环境条件下可被降解释放,进而实现肿瘤光动力学治疗。通过检测NPs的粒径、电势、紫外吸收和荧光吸收对其进行结构性质表征,应用单线态氧绿色荧光探针(single oxygen sensor green,SOSG)试剂盒检测NPs体外单线态氧的产生,以小鼠乳腺癌细胞4T1为研究对象,考察NPs的亚细胞器分布和细胞毒性等。研究结果表明,NPs具有良好的分散性和稳定性,结构均一,粒径约为165 nm,具有肿瘤微环境响应性,能有效抑制4T1细胞活性,诱导细胞凋亡。本研究表明,基于组氨酸和锌离子配位的仿生纳米药物具有良好的生物相容性和小鼠乳腺癌细胞毒性,该组装配位策略可为开发新型智能纳米药物带来新思考。 展开更多
关键词 组氨酸 锌离子 纳米药物 配位效应 肿瘤微环境 光动力学治疗
抗癌纳米药物共递送系统的应用研究 认领
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作者 吴天怡 龚妍春 +2 位作者 李资玲 李玉萍 熊向源 《材料导报》 EI CAS CSCD 北大核心 2020年第S01期516-522,共7页
近年来,运用纳米制剂靶向技术治疗癌症取得了很好的疗效,尤其是共递送多种抗癌药物。相比单一药物,联合应用不同药物分子靶向治疗范围更广,能有效地降低药物的毒副作用,或是相同细胞通路的抗癌药物组合疗法,减少每种药物剂量并增强疗效... 近年来,运用纳米制剂靶向技术治疗癌症取得了很好的疗效,尤其是共递送多种抗癌药物。相比单一药物,联合应用不同药物分子靶向治疗范围更广,能有效地降低药物的毒副作用,或是相同细胞通路的抗癌药物组合疗法,减少每种药物剂量并增强疗效,均可能在一定程度上逆转多药耐药性。但是,组合给药因不同药物的药代动力学差异导致药物摄取不一致而受到限制,而且疗效与组合药物的相对浓度关系密切,一定比例的药物组合产生协同作用,而其他比例则可能是加和作用或拮抗作用。目前,脂质体、聚合物胶束、高分子囊泡、树枝状大分子、水凝胶和无机纳米粒子在内的纳米载体已被证明能成功地在各种肿瘤模型中共递送抗癌药物。这些纳米载体可改善药物的血清稳定性,提高生物相容性,延长在体内的循环时间。本文主要论述抗癌药物共递送原理、常见共递送载体类型以及CombiPlex平台完成临床试验的两种脂质体制剂和三类仍处于临床前研究的经典共递送系统,包括阿霉素和紫杉醇共递送系统、紫杉醇和顺铂共递送系统、阿霉素和姜黄素共递送系统,旨在为更多联合给药方案提供参考和新思路。 展开更多
关键词 纳米药物 共递送 抗癌药物 多药耐药性
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