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Locus coeruleus-norepinephrine:basic functions and insights into Parkinson's disease 预览
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作者 Bilal Abdul Bari Varun Chokshi Katharina Schmidt 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1006-1013,共8页
The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine.Despite its small size,the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative ... The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine.Despite its small size,the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders.In this review,we discuss the physiology and anatomy of the locus coeruleus system and focus on norepinephrine's role in synaptic plasticity.We highlight Parkinson's disease as a disorder with motor and neuropsychiatric symptoms that may be understood as aberrations in the normal functions of locus coeruleus. 展开更多
关键词 CATECHOLAMINES copper neurodegenerative diseases NEUROMODULATION neuronal circuits neuropsychiatric symptoms NORADRENALINE synaptic plasticity
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Human Brain Slice Culture: A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds
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作者 Xin-Rui Qi Ronald W.H.Verwer +4 位作者 Ai-Min Bao Rawien A.Balesar Sabina Luchetti Jiang-Ning Zhou Dick F.Swaab 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第2期244-252,共9页
Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed. In vivo studies of animal models and in vitro studies of cell lines/primary... Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed. In vivo studies of animal models and in vitro studies of cell lines/primary cell cultures may provide useful tools to study certain aspects of brain disorders. However, discrepancies among these studies or unsuccessful translation from animal/cell studies to human/clinical studies often occur, because these models generally represent only some symptoms of a neuropsychiatric disorder rather than the complete disorder. Human brain slice cultures from postmortem tissue or resected tissue from operations have shown that, in vitro, neurons and glia can stay alive for long periods of time, while their morphological and physiological characteristics, and their ability to respond to experimental manipulations are maintained. Human brain slices can thus provide a close representation of neuronal networks in vivo, be a valuable tool for investigation of the basis of neuropsychiatric disorders, and provide a platform for the evaluation of novel pharmacological treatments of human brain diseases.A brain bank needs to provide the necessary infrastructure to bring together donors, hospitals, and researchers who want to investigate human brain slices in cultures of clinically and neuropathologically well-documented material. 展开更多
关键词 Alzheimer’s disease BRAIN bank Brain-derived neurotrophic factor Depression Electrical activity HUMAN BRAIN slice CULTURE Neuropsychiatric disorders ORGANOTYPIC CULTURE POSTMORTEM HUMAN BRAIN TISSUE Resected HUMAN BRAIN TISSUE
Sleep quality of spousal caregivers is associated with neuropsychiatric symptoms and living ability of patients with Alzheimer disease
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作者 Yi Chen Jun-Yang Wang +3 位作者 Xiao-Yan Liu Fan-Xia Meng Ai-Ping Li Guo-Ping Peng 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第12期1490-1493,共4页
Alzheimer disease (AD) is the most common neurodegenerative disorder, accounting for the majority of cases of dementia. The global prevalence of AD is rising, representing an increasing challenge for older individuals... Alzheimer disease (AD) is the most common neurodegenerative disorder, accounting for the majority of cases of dementia. The global prevalence of AD is rising, representing an increasing challenge for older individuals and their families.[1] Seven out of every ten patients with AD receive informal care at home, relying on co-resident family members, especially spouses.[2] However, cultural differences exist in the effects of the disorder. For example, Chinese caregivers of patients with dementia had higher scores on measures of depression and caregiver burden compared with caregivers of patients with dementia in Western societies.[3] It is important to consider that AD not only affects the patient but also their caregivers, particularly spousal caregivers who spend more than half their time with the patient.[4] As AD progresses, patients become increasingly dependent on caregivers. Meanwhile, there is an increasingly heavy caregiver burden, characterized as the physical, psychological, or emotional, social, and financial problems experienced by family members who care for impaired older adults.[5] Additionally, it is frequently reported that sleep disturbance symptoms are associated with health consequences among AD caregivers.[6] 展开更多
关键词 SLEEP quality spousal CAREGIVERS NEUROPSYCHIATRIC SYMPTOMS
Neuropsychiatric Symptoms,Parenting Stress and Social Support in Chinese Mothers of Children with Autism Spectrum Disorder 预览
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作者 Xiao-qian HUANG Hong ZHANG Shan CHEN 《当代医学科学(英文)》 SCIE CAS 2019年第2期291-297,共7页
Although little is known about the current situation regarding autism spectrum disorder(ASD)in main land China,psychiatric disorders are common among Chinese mothers of preschool children with ASD.Previous studies sho... Although little is known about the current situation regarding autism spectrum disorder(ASD)in main land China,psychiatric disorders are common among Chinese mothers of preschool children with ASD.Previous studies showed ASD child's behavioral symptoms,maternal anxiety,and maternal depressive symptoms were associated with overall parenting stress in northern China.In the present study,we retrospectively analyzed medical records at the hospital related to neuropsychiatric symptoms,parenting stress and social support in mothers of children with ASD from southern China.A total of 80 mothers of children with ASD were screened.Among them,34 mothers were in low-functioning ASD group(L-ASD group)and 46 mothers were in highfunctioning ASD group(H-ASD group).Identification of the ASD cases was confirmed with a Revised Autism Diagnostic Inventory.Neuropsychiatric symptoms,parenting stress and social support were measured by neuropsychiatric inventory(NPI),parenting stress index short form(PSISF),and multi-dimensional scale of perceived social support(MSPSS).Total mean score of the NPI in the L-ASD group was significantly higher than that in the H-ASD group(P<0.01).The subscale scores of NPI,including depression,anxiety,apathy,irritability,agitation,night time behavior disturbances and change in appetite were significantly higher in the L-ASD group than those in the H-ASD group(P<0.01 or P<0.05).Meanwhile,the total PSI-SF scores and the scores of parental distress(PD),parental-child dysfunctional interaction(PCDI)and difficult child(DC)in the L-ASD group were significantly higher than those in the H-ASD group(P<0.01 or P<0.05).The total score of MSPSS was also higher in the L-ASD group than in the H-ASD group(P<0.01).This study goes further to show the neuropsychiatric symptoms and parenting stress are significantly higher in mothers of children with ASD,and more social supports are needed for mothers of children with ASD from southern China,especially for mothers of children with low-functioning ASD. 展开更多
关键词 AUTISM SPECTRUM DISORDER NEUROPSYCHIATRIC SYMPTOMS PARENTING stress social support mothers
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Neuropsychiatric Symptoms and Cognitive Impairment in Chinese Patients with Parkinson's Disease in Han and Hui Ethnicity 预览
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作者 Mei-ling YAO Hong ZHANG +4 位作者 Yan XU Sheng-ming ZHANG Yong-zhe GAO Min SHU Jun-Jian ZHANG 《当代医学科学(英文)》 SCIE CAS 2019年第1期122-126,共5页
Nenropsychiatric symptoms are common in patients with Parkinson's disease(PD)and they are likely to outweigh the motor symptoms and become a major factor affecting the quality of life of PD patients.However,the st... Nenropsychiatric symptoms are common in patients with Parkinson's disease(PD)and they are likely to outweigh the motor symptoms and become a major factor affecting the quality of life of PD patients.However,the studies focusing on the non-motor symptoms in Chinese PD patients from different ethnicity are scarce.The aim of this retrospective study was to investigate neuropsychiatric symptoms and cognitive impairment in Chinese PD patients from Han and Hui populations from central China.Seventy-two Han Chinese PD patients(Han PD group)and 71 age-and sex-matched Hui Chinese PD patients(Hui PD group)were enrolled from Zhongnan Hospital of Wuhan University between Sept.2011 and Aug.2014 in the study.The neuropsychiatric symptoms and cognitive impairment were assessed using Neuropsychiatric Inventory(NPI)and Mini Mental State Examination(MMSE).We found that the proportion of depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were higher in the Han PD group than in the Hui PD group(P<0.05 or P<0.01).But the proportion of delusion,hallucination,agitation,disinhibition,aberrant motor behavior and change in appetite were not significantly different between the Han PD group and the Hui PD group(P>0.05).The total mean scores of the MMSE from patients in the Han PD group were similar to those in the Hui PD group(P>0.05).However,the subscale scores of recall domain and language domain in the Han PD group were significantly different from those in the Hui PD group(P<0.05).No significant difference was noted in the orientation,memory and calculation domains between the two PD groups(P>0.05).This study first showed the recall domain and language domain were different between the Han PD patients and the Hui PD patients.Depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were less presented in the Hui PD patients.All these differences may be related to the different ethnicity,which would be helpful for clinical physicians to recognize the different non-motor symptom 展开更多
关键词 Parkinson's disease NEUROPSYCHIATRIC symptoms cognitive impairment HAN CHINESE HUI CHINESE
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Cerebral organoids exhibit mature neurons and astrocytes and recapitulate electrophysiological activity of the human brain 预览
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作者 Abraam M.Yakoub 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第5期757-761,共5页
Multiple protocols have been devised to generate cerebral organoids that recapitulate features of the developing human brain,including the presence of a large,multi-layered,cortical-like neuronal zone.However,the cent... Multiple protocols have been devised to generate cerebral organoids that recapitulate features of the developing human brain,including the presence of a large,multi-layered,cortical-like neuronal zone.However,the central question is whether these organoids truly present mature,functional neurons and astrocytes,which may qualify the system for in-depth molecular neuroscience studies focused at neuronal and synaptic functions.Here,we demonstrate that cerebral organoids derived under optimal differentiation conditions exhibit mature,fully functional neurons and astrocytes,as validated by immunohistological,gene expression,and electrophysiological,analyses.Neurons in cerebral organoids showed gene expression profiles and electrophysiological properties similar to those reported for fetal human brain.These important findings indicate that cerebral organoids recapitulate the developing human brain and may enhance use of cerebral organoids in modeling human brain development or investigating neural deficits that underlie neurodevelopmental and neuropsychiatric conditions,such as autism or intellectual disorders. 展开更多
关键词 CEREBRAL ORGANOIDS human brain stem cells NEURONS ASTROCYTES NEURODEVELOPMENTAL DISORDERS neuropsychiatric DISORDERS autism
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Repeatability of two-dimensional chemical shift imaging multivoxel proton magnetic resonance spectroscopy for measuring human cerebral choline-containing compounds 预览
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作者 Basant K Puri Mary Egan +1 位作者 Fintan Wallis Philip Jakeman 《世界精神病学杂志》 2018年第1期20-26,共7页
AIM To investigate the repeatability of proton magnetic resonance spectroscopy in the in vivo measurement of human cerebral levels of choline-containing compounds(Cho).METHODS Two consecutive scans were carried out in... AIM To investigate the repeatability of proton magnetic resonance spectroscopy in the in vivo measurement of human cerebral levels of choline-containing compounds(Cho).METHODS Two consecutive scans were carried out in six healthy resting subjects at a magnetic field strength of 1.5 T.On each occasion,neurospectroscopy data were collected from 64 voxels using the same 2D chemical shift imaging(CSI)sequence.The data were analyzed in the same way,using the same software,to obtain the values for each voxel of the ratio of Cho to creatine.The Wilcoxon related-samples signed-rank test,coefficient of variation(CV),repeatability coefficient(RC),and intraclass correlation coefficient(ICC)were used to assess the repeatability.RESULTS The CV ranged from 2.75%to 33.99%,while the minimum RC was 5.68%.There was excellent reproducibility,as judged by significant ICC values,in 26 voxels.Just three voxels showed significant differences according to the Wilcoxon related-samples signed-rank test.CONCLUSION It is therefore concluded that when CSI multivoxel proton neurospectroscopy is used to measure cerebral choline-containing compounds at 1.5 T,the reproducibility is highly acceptable. 展开更多
关键词 CEREBRAL METABOLITES Chemical shift imaging CHOLINE Neurospectroscopy NEUROPSYCHIATRIC disorders
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剖宫产对新生儿近远期的影响 被引量:6
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作者 吴立志 周晓玉 《中华实用儿科临床杂志》 CAS CSCD 北大核心 2015年第14期1114-1116,共3页
虽然剖宫产已逐渐成为解决难产和高危妊娠等产科危重症的有效手段,但新生儿疾病的发病率及其 NICU 住院率并未因剖宫产率的不断增高而明显减少,相反,近年来国内外诸多研究发现相比较正常阴道分娩儿,剖宫产儿在出生后有较高的新生儿... 虽然剖宫产已逐渐成为解决难产和高危妊娠等产科危重症的有效手段,但新生儿疾病的发病率及其 NICU 住院率并未因剖宫产率的不断增高而明显减少,相反,近年来国内外诸多研究发现相比较正常阴道分娩儿,剖宫产儿在出生后有较高的新生儿相关疾病发病率,以呼吸窘迫综合征、新生儿暂时性呼吸困难、持续肺动脉高压、感染等最为常见,更为值得关注的是剖宫产儿在儿童期和成年期也更易于患过敏性及免疫系统疾病和神经精神相关性疾病。现就剖宫产对新生儿近远期的影响进行综述。 展开更多
关键词 剖宫产 婴儿 新生 呼吸 免疫 精神神经 近远期
Psychiatric aspects of brain tumors:A review 预览
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作者 Subramoniam Madhusoodanan Mark Bryan Ting +1 位作者 Tara Farah Umran Ugur 《世界精神病学杂志》 2015年第3期273-285,共13页
Infrequently,psychiatric symptoms may be the only manifestation of brain tumors.They may present with mood symptoms,psychosis,memory problems,personality changes,anxiety,or anorexia.Symptoms may be misleading,complica... Infrequently,psychiatric symptoms may be the only manifestation of brain tumors.They may present with mood symptoms,psychosis,memory problems,personality changes,anxiety,or anorexia.Symptoms may be misleading,complicating the clinical picture.A comprehensive review of the literature was conducted regarding reports of brain tumors and psychiatric symptoms from 1956-2014.Search engines used include PubMed,Ovid,Psych Info,MEDLINE,and MedScape.Search terms included psychiatric manifestations/symptoms,brain tumors/neoplasms.Our literature search yielded case reports,case studies,and case series.There are no double blind studies except for post-diagnosis/-surgery studies.Early diagnosis is critical for improved quality of life.Symptoms that suggest work-up with neuroimaging include:new-onset psychosis,mood/memory symptoms,occurrence of new or atypical symptoms,personality changes,and anorexia without body dysmorphic symptoms.This article reviews the existing literature regarding the diagnosis and management of this clinically complex condition. 展开更多
关键词 Brain TUMORS PSYCHIATRIC SYMPTOMS NEUROPSYCHIATRIC BEHAVIORAL SYMPTOMS Diagnosis Management NEUROIMAGING
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Epilepsy triggered by mefloquine in an adult traveler to Uganda 预览
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作者 Federico Gobbi Andrea Rossanese +3 位作者 Dora Buonfrate Andrea Angheben Chiara Postiglione Zeno Bisoffi 《世界临床病例杂志》 2014年第1期12-15,共4页
We report a case of a traveler who visited Uganda for 8 d,and took mefloquine one tablet/week for malaria prophylaxis.After the second dose,he suffered from two episodes of loss of consciousness with seizures,therefor... We report a case of a traveler who visited Uganda for 8 d,and took mefloquine one tablet/week for malaria prophylaxis.After the second dose,he suffered from two episodes of loss of consciousness with seizures,therefore mefloquine was discontinued.During the flight back after full recovery,seizures reoccurred while he was on board,he was disembarked in Addis Ababa and then transferred to Nairobi.After repatriation to Italy,he experienced four other similar episodes.The patient was still on full dose anticonvulsant therapy one year and a half after,as any attempt at reduced dose was unsuccessful.Currently,three agents(mefloquine,atovaquone/proguanil,and doxycycline)are recommended for malaria chemoprophylaxis,with similar efficacy but different adverse event profiles,regimens,and prices.Considering that mefloquine is associated with a higher risk of neurologic and psychiatric adverse events than the alternative regimens,we suggest considering mefloquine as a second line choice after atovaquone/proguanil and doxycycline for short-term travelers. 展开更多
关键词 MEFLOQUINE NEUROPSYCHIATRIC disorders EPILEPSY ANTIMALARIAL CHEMOPROPHYLAXIS Side effects
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抗核糖体P蛋白抗体在新疆青少年系统性红斑狼疮中临床意义 预览 被引量:1
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作者 赵春梅 刘慧 +5 位作者 王彦焱 孟岩 古丽仙 张新玉 贾娜 罗莉 《新疆医科大学学报》 CAS 2013年第7期965-969,共5页
目的探讨抗核糖体P蛋白抗体(Ribosomal Pantibodies,anti-P)在新疆青少年系统性红斑狼疮(Ju-venile SLE)患者中的临床意义。方法无选择性连续收集2007—2012年79例青少年系统性红斑狼疮患者,其中34例anti-P阳性和45例anti-P阴性青少... 目的探讨抗核糖体P蛋白抗体(Ribosomal Pantibodies,anti-P)在新疆青少年系统性红斑狼疮(Ju-venile SLE)患者中的临床意义。方法无选择性连续收集2007—2012年79例青少年系统性红斑狼疮患者,其中34例anti-P阳性和45例anti-P阴性青少年SLE患者,两组进行前瞻性病例对照研究,分析比较两组临床特征、自身抗体和治疗方面的差异。结果与anti-P阴性组相比,anti-P阳性组患者发病时年龄较小,关节炎和神经精神狼疮(Neuropsychiatric SLE,NPSLE)的发生率明显升高,差异具有统计学意义(P〈0.05),anti-P阳性组患者病情活动指数高于anti-P阴性组,差异具有统计学意义(P〈0.05)。与anti-P阴性组相比,anti-P阳性组患者血清中抗aCL抗体阳性率较高(P〈0.05)。两组种族、性别、狼疮肾炎及其他临床表现和自身抗体比较,差异无统计学意义(P〉0.05)。Anti-P阳性组患者环磷酰胺使用率高于anti-P阴性组(P〈0.05)。NPSLE患者主要表现为认知障碍(59.1%)和头痛(50.0%),其次为癫痫(36.4%)和抑郁状态(27.3%)。Anti-P阳性组患者认知障碍和抑郁发生率高于anti-P阴性组,但差异无统计学意义(P〉0.05)。结论新疆地区anti-P阳性的青少年SLE患者发病年龄偏小,临床上更易出现关节炎和神经精神狼疮,病情活动度高,多伴有aCL抗体阳性,更多患者使用环磷酰胺治疗。 展开更多
关键词 抗核糖体P蛋白 青少年 系统性红斑狼疮 神经精神狼疮 新疆
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Nucleus accumbens stereotactic surgery:Achieving accuracy through area M 预览
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作者 Ioannis N Mavridis 《世界神经病学杂志》 2013年第2期7-9,共3页
The nucleus accumbens(NA),a major pleasure center of the human brain,is a limbic-motor interface involved in several neurological and psychiatric disorders.During the last decade,this nucleus is also a deep brain stim... The nucleus accumbens(NA),a major pleasure center of the human brain,is a limbic-motor interface involved in several neurological and psychiatric disorders.During the last decade,this nucleus is also a deep brain stimulation target for selected patients.Purpose of this paper is to comment on the article entitled“Stereotactic anatomy of the human nucleus accumbens:from applied mathematics to microsurgical accuracy”which was recently published in“Surgical and Radiologic Anatomy”and is one of the latest articles on NA anatomy and surgery.The described results included a probabilitybased guide for in vivo(side-depended)stereotactic localization of the human NA and a standard for the NA,specific stereotactic zone of the human brain(which can be used in combination for an accurate stereotactic NA targeting).Furthermore,two specific stereotactically standard NA areas were found which could be used as abundant stereotactic guides for targeting of the anterior limb of the internal capsule,with electrode’s contact 0(lowest)placed in the vicinity of the NA.However,the most important finding of this paper was standard area M(Mavridis’area),which is the most reliable stereotactically standard area of the human NA,regardless of side or gender,useful for highly accurate stereotactic NA targeting. 展开更多
关键词 Mavridis'area Deep brain stimulation NEUROPSYCHIATRIC DISORDERS NUCLEUS ACCUMBENS STEREOTACTIC surgery Surgical ACCURACY
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Neurocysticercosis Association with Cognitive and Aberrant Behavioural Symptoms: A Case Report and Review 预览
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作者 Rohit Verma Kuljeet Singh Anand +2 位作者 Mina Chandra Neha Prakash Ankur Sachdeva 《行为与脑科学期刊(英文)》 2011年第4期229-233,共5页
Neurocysticercosis (NCC) is a leading cause of seizures and epilepsy worldwide. Its clinical manifestations are varied, non specific and pleomorphic, depending on multiple factors. Since NCC mimic large number of neur... Neurocysticercosis (NCC) is a leading cause of seizures and epilepsy worldwide. Its clinical manifestations are varied, non specific and pleomorphic, depending on multiple factors. Since NCC mimic large number of neurological disorders, it is important that clinicians should be familiar with these rare presentations to avoid delay in diagnosis and management. We herein describe an unusual case of multiple NCC’s involving entire cortex with only cognitive and behavioural manifestations and review pertinent literature. 展开更多
关键词 NEUROCYSTICERCOSIS DEMENTIA NEUROPSYCHIATRIC
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神经精神性狼疮脑电图及临床分析 预览 被引量:1
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作者 付明 余明 《中国现代医生》 2008年第15期 82-84,共3页
目的通过脑电图检测和临床转归,观察甲基泼尼松龙和环磷酰胺单剂及联合冲击治疗神经精神性狼疮的疗效和不良反应。方法36例神经精神性狼疮患者随机分为3组,分别应用甲基泼尼松龙(A组)、环磷酰胺(B组)、甲基泼尼松龙联合环磷酰胺(... 目的通过脑电图检测和临床转归,观察甲基泼尼松龙和环磷酰胺单剂及联合冲击治疗神经精神性狼疮的疗效和不良反应。方法36例神经精神性狼疮患者随机分为3组,分别应用甲基泼尼松龙(A组)、环磷酰胺(B组)、甲基泼尼松龙联合环磷酰胺(c组)冲击治疗;动态观察脑电图改变、SLE疾病活动指数、血清补体C3、IgG含量及ANA、抗ds—DNA抗体、抗Sm抗体的转阴率,评估其疗效和不良反应。结果(1)治疗6个月后显效的15例患者脑电图完全恢复正常者13例;好转的11例患者中4例恢复正常;无效的10例患者轻度异常2例,中度异常4例,重度异常2例。(2)治疗后1、6个月后3组SLE疾病活动指数降低、血清补体C3、IgG含量及ANA、抗ds—DNA抗体、抗sm抗体的转阴率均增高,较治疗前有显著性差异(均P〈0.01),而且C组的上述指标变化显著优于A、B两组(P〈0.05或0.01);(3)治疗1、6个月后,C组显效率(40%/60%)明显高于A组(14%/28%)、B组(17%/42%),P〈0.05或0.01;A、B两组显效率无显著性差异(P〉0.05)。结论甲基泼尼松龙和环磷酰胺联合冲击治疗神经精神性狼疮疗效优于单剂冲击治疗.脑电图改变与临床改变呈正相关。 展开更多
关键词 系统性红斑狼疮 神经精神性 脑电图 治疗
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神经相关性自身抗体检测在神经精神性狼疮中的意义 被引量:1
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作者 邵晓凤 李永哲 +3 位作者 苏茵 赵卫 崔巍 粟占国 《中华风湿病学杂志》 CAS CSCD 2008年第8期519-523,I0001共6页
目的探讨神经相关性自身抗体在系统性红斑狼疮(SLE)和神经精神性狼疮(NPSLE)患者血清或脑脊液中的敏感性和特异性,评价其在NPSLE诊断中的意义。方法利用间接免疫荧光法分别以成神经瘤细胞株(SK—N—SH)、神经胶质瘤细胞株(U251... 目的探讨神经相关性自身抗体在系统性红斑狼疮(SLE)和神经精神性狼疮(NPSLE)患者血清或脑脊液中的敏感性和特异性,评价其在NPSLE诊断中的意义。方法利用间接免疫荧光法分别以成神经瘤细胞株(SK—N—SH)、神经胶质瘤细胞株(U251)以及C57BL/10小鼠的大脑及脊髓切片为底物检测121例s㈨患者、34例疾病对照组和34名健康对照组的血清及24例NPSLE患者和22例疾病对照组的脑脊液中抗神经元细胞抗体、抗神经胶质细胞抗体、抗脑抗体及抗脊髓抗体。结果SLE患者血清中抗神经元细胞抗体、抗脑抗体及抗脊髓抗体的阳性率(17.4%、25.6%和29.8%)明显高于类风湿关节炎(RA)患者以及正常对照组(P〈0.05或P〈0.01),在SLE诊断中的特异性分别为98.5%、95.6%和100%;抗神经元细胞抗体、抗脑抗体及抗脊髓抗体均与SLE疾病活动性指数(SLEDAI)积分呈正相关,并与NPSLE患者的癫痫发作、头痛、急性意识障碍以及情绪失调、焦虑等症状的发生有关;NPSLE患者血清的抗神经元细胞抗体、抗脑抗体和抗脊髓抗体的阳性率(27.8%、38.9%和61.1%)明显高于无中枢神经系统受累的SLE患者(P〈0.05或P〈0.01);NPSLE患者的脑脊液中抗脑抗体、抗脊髓抗体的阳性率均为29.2%,与疾病对照组比较,差异具有统计学意义(P〈0.05或P〈0.01);在NPSLE诊断中的特异性分别为100%和95.5%。结论抗神经元细胞抗体、抗脑抗体及抗脊髓抗体对SLE诊断的特异性较高,但敏感性偏低;3种抗体均与SLE疾病活动性相关;血清中抗神经元细胞抗体、抗脑抗体及抗脊髓抗体是NPSLE诊断的较特异性抗体,抗脊髓抗体可能是诊断NPSLE较敏感的指标之一;脑脊液中的抗脑抗体、抗脊髓抗体对NPSLE的诊断更具有特异性。 展开更多
关键词 红斑狼疮 系统性 神经精神性狼疮 神经相关性自身抗体 间接免疫荧光法
神经精神狼疮预后相关因素的临床分析 被引量:4
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作者 范维 吕良敬 鲍春德 《中华风湿病学杂志》 CAS CSCD 2007年第8期 482-485,共4页
目的 探讨影响神经精神狼疮(NPSLE)患者预后相关因素。方法 对76例NPSLE患者进行回顾性分析并逐例随访至2005年12月底。先对患者的57项临床相关因素进行COX回归模型单因素分析,再将有意义的变量进行COX回归模型多因素分析.分析NPSL... 目的 探讨影响神经精神狼疮(NPSLE)患者预后相关因素。方法 对76例NPSLE患者进行回顾性分析并逐例随访至2005年12月底。先对患者的57项临床相关因素进行COX回归模型单因素分析,再将有意义的变量进行COX回归模型多因素分析.分析NPSLE预后相关因素。结果 76例NPSLE患者中共有14种神经精神症状,单因素分析显示病程、感染、横贯性脊髓炎、浆膜炎、糖尿病、中重度贫血、低蛋白血症、白球比例、蛋白尿、血小板减少、红细胞沉降率、环磷酰胺(CTX)的应用12项因素与NPSLE的预后相关(P〈0.05)。进一步行多因素分析,结果显示感染、横贯性脊髓炎、中重度贫血、血小板减少与NPSLE不良预后相关(P〈0.05),是独立的危险因素,而CTX的应用与NPSLE预后改善相关(P〈0.05),是独立的保护性因素。结论 感染、横贯性脊髓炎、血小板减少、中重度贫血是NPSLE预后的高危因素,提示预后不良;而CTX的应用是疾病预后的保护性因素,可提高NPSLE患者的生存率,应早期应用。 展开更多
关键词 红斑狼疮 系统性 神经精神性 预后相关因素
神经精神狼疮的治疗策略 预览 被引量:1
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作者 陆晓晔 顾越英 王元 《中华临床免疫和变态反应杂志》 2007年第2期 202-206,共5页
神经精神狼疮的临床表现多样,在治疗上颇具难度和挑战性,目前多为经验化和个体化治疗,治疗方案因发病机制和神经系统表现轻重而有差异。联合应用激素和免疫抑制剂对神经精神狼疮有效而不增加毒副作用。环磷酰胺的冲击治疗对重症和难... 神经精神狼疮的临床表现多样,在治疗上颇具难度和挑战性,目前多为经验化和个体化治疗,治疗方案因发病机制和神经系统表现轻重而有差异。联合应用激素和免疫抑制剂对神经精神狼疮有效而不增加毒副作用。环磷酰胺的冲击治疗对重症和难治病例有效。 展开更多
关键词 系统性红斑狼疮 神经精神性 治疗策略
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神经精神性狼疮的预后分析 预览 被引量:1
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作者 梁志安 俞万香 罗伟文 《中国热带医学》 CAS 2006年第7期 1296-1297,共2页
目的 探讨影响神经精神性狼疮预后的因素。方法回顾性分析95例住院患者的临床资料,以死亡为阳性结局,对性别、年龄、病程、并发症,狼疮活动指数,实验室检查和治疗措施等36项指标,进行Logistic回归分析,计算OR值及其95%CI。结果9... 目的 探讨影响神经精神性狼疮预后的因素。方法回顾性分析95例住院患者的临床资料,以死亡为阳性结局,对性别、年龄、病程、并发症,狼疮活动指数,实验室检查和治疗措施等36项指标,进行Logistic回归分析,计算OR值及其95%CI。结果95例神经精神性狼疮患者中23例死亡,占24.21%。单因素分析显示,年龄、器质性脑病、脑血管意外、肾功能不全、肝功能损害、心功能不全、合并感染、SLEDAI〉30、MRI阳性、CTX冲击治疗、甲基泼尼松龙冲击治疗和MTX/DXM鞘内注射均与NPLE的预后有关。进一步多因素分析发现,脑血管意外、心功能不全以及SLEDAI〉30是神经精神性狼疮死亡的独立危险因素;而规则的CTX、甲强龙冲击治疗和MTX/DXM鞘内注射是保护性因素。结论神经精神性狼疮患者合并脑血管意外、心功能不全、和SLEDAI〉30提示预后不良;规则运用CTX、甲强龙冲击治疗和MTX/DXM鞘内注射可以减少死亡,改善预后。 展开更多
关键词 系统性红斑狼疮 并发症 预后
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间接免疫荧光法检测神经精神狼疮患者神经反应性自身抗体的临床意义 被引量:3
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作者 陆晓晔 叶霜 +7 位作者 王元 郭玲 陈晓翔 范维 王晓栋 顾越英 鲍春德 刘强 《中华医学杂志》 CAS CSCD 北大核心 2006年第35期 2462-2466,共5页
目的 探讨神经精神狼疮(NPSLE)患者血清/脑脊液(CSF)中特异/非特异的神经反应性自身抗体,在NPSLE发病中的作用.方法 收集NPSLE组25例患者和系统性红斑狼疮(SLE)伴中枢神经系统(CNS)感染对照组11例患者的血清和脑脊液,另收集SLE... 目的 探讨神经精神狼疮(NPSLE)患者血清/脑脊液(CSF)中特异/非特异的神经反应性自身抗体,在NPSLE发病中的作用.方法 收集NPSLE组25例患者和系统性红斑狼疮(SLE)伴中枢神经系统(CNS)感染对照组11例患者的血清和脑脊液,另收集SLE不伴神经精神累及(non-NPSLE)对照组10例患者血清,分别以人喉癌上皮细胞(Hep-2)和猴小脑组织和外周神经薄片为抗原基质检测自身抗体荧光模型.结果N PSLE组和两组SLE对照组血清抗核抗体(ANA)阳性率差异无统计学意义(P>0.05),NPSLE组CSF的ANA阳性率为60%(15/25),SLE感染对照组为27%(3/11)(P<0.01);PSLE组血清神经组织反应性抗体的阳性率显著高于SLE感染对照组和non-NPSLE对照组比较差异有统计学意义(P<0.001).结论 (1)SLE患者CSF ANA阳性率与SLE活动和神经系统累及有关,尤其重症病例可见较高滴度;(2)血清中神经组织反应性自身抗体阳性与NPSLE发病有关,其产生和发病机制有待探究. 展开更多
关键词 红斑狼疮 系统性 神经精神性 自身抗体
系统性红斑狼疮脑脊液抗核抗体测定的临床意义 预览 被引量:1
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作者 戴艳 汪兴洪 +3 位作者 陆进明 苏贵平 黄东平 张岱云 《皖南医学院学报》 CAS 2004年第4期 263-265,共3页
目的探讨系统性红斑狼疮(SLE)患者脑脊液(CSF)中抗核抗体(ANA)的定量测定对神经精神性狼疮(NPLE)的诊断价值.方法对28例SLE患者采用间接免疫荧光法检测CSF及血清中ANA滴度,同时进行CSF的常规、生化检测.对NPLE及非NPLE狼疮患者进行统计... 目的探讨系统性红斑狼疮(SLE)患者脑脊液(CSF)中抗核抗体(ANA)的定量测定对神经精神性狼疮(NPLE)的诊断价值.方法对28例SLE患者采用间接免疫荧光法检测CSF及血清中ANA滴度,同时进行CSF的常规、生化检测.对NPLE及非NPLE狼疮患者进行统计学分析与比较.结果两组患者CSF糖、细胞数、氯化物无显著差异,NPLE患者CSF的ANA滴度≥1:100,阳性率高于非NPLE组;另外NPLE组血中ANA滴度显著高于非NPLE组,经治疗后NPLE组CSF中ANA滴度1:100阳性率下降 .结论 SLE患者CSF中ANA的定量检测,有助于NPLE的早期诊断,并为治疗及预后提供参考. 展开更多
关键词 ANA 患者 CSF 滴度 SLE 系统性红斑狼疮 抗核抗体 显著差异 常规 参考
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