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Extracellular vesicles in the diagnosis and treatment of central nervous system diseases 预览
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作者 Alisa A.Shaimardanova Valeriya V.Solovyeva +3 位作者 Daria S.Chulpanova Victoria James Kristina V.Kitaeva Albert A.Rizvanov 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期586-596,共11页
Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central n... Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems.In many neurodegenerative diseases,neurons pack toxic substances into vesicles and release them into the extracellular space,which leads to the spread of misfolded neurotoxic proteins.The contents of neuron-derived extracellular vesicles may indicate pathological changes in the central nervous system,and the analysis of extracellular vesicle molecular content contributes to the development of non-invasive methods for the diagnosis of many central nervous system diseases.Extracellular vesicles of neuronal origin can be isolated from various biological fluids due to their ability to cross the blood-brain barrier.Today,the diagnostic potential of almost all toxic proteins involved in nervous system disease pathogenesis,specificallyα-synuclein,tau protein,superoxide dismutase 1,FUS,leucine-rich repeat kinase 2,as well as some synaptic proteins,has been well evidenced.Special attention is paid to extracellular RNAs mostly associated with extracellular vesicles,which are important in the onset and development of many neurodegenerative diseases.Depending on parental cell type,extracellular vesicles may have different therapeutic properties,including neuroprotective,regenerative,and anti-inflammatory.Due to nano size,biosafety,ability to cross the blood-brain barrier,possibility of targeted delivery and the lack of an immune response,extracellular vesicles are a promising vehicle for the delivery of therapeutic substances for the treatment of neurodegenerative diseases and drug delivery to the brain.This review describes modern approaches of diagnosis and treatment of central nervous system diseases using extracellular vesicles. 展开更多
关键词 biomarkers cell-mediated therapy central nervous system DISEASES diagnosis EXOSOMES EXTRACELLULAR RNAS EXTRACELLULAR vesicles microRNAs MICROVESICLES NEURODEGENERATIVE DISEASES
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Current status and future prospects of stem cell therapy in Alzheimer’s disease 预览
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作者 Fu-Qiang Zhang Jin-Lan Jiang +3 位作者 Jing-Tian Zhang Han Niu Xue-Qi Fu Lin-Lin Zeng 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期242-250,共9页
Alzheimer’s disease is a common progressive neurodegenerative disorder, pathologically characterized by the presence of β-amyloid plaques and neurofibrillary tangles. Current treatment approaches using drugs only al... Alzheimer’s disease is a common progressive neurodegenerative disorder, pathologically characterized by the presence of β-amyloid plaques and neurofibrillary tangles. Current treatment approaches using drugs only alleviate the symptoms without curing the disease, which is a serious issue and influences the quality of life of the patients and their caregivers. In recent years, stem cell technology has provided new insights into the treatment of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Currently, the main sources of stem cells include neural stem cells, embryonic stem cells, mesenchymal stem cells, and induced pluripotent stem cells. In this review, we discuss the pathophysiology and general treatment of Alzheimer’s disease, and the current state of stem cell transplantation in the treatment of Alzheimer’s disease. We also assess future challenges in the clinical application and drug development of stem cell transplantation as a treatment for Alzheimer’s disease. 展开更多
关键词 Alzheimer's disease β-amyloid drug development embryonic STEM CELLS induced PLURIPOTENT STEM CELLS mesenchymal STEM CELLS nerve REGENERATION NEURAL REGENERATION NEURAL STEM CELLS NEURODEGENERATIVE disorders STEM cell therapy
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Novel pluripotent stem cell lines for enriched grafting in Parkinson's disease 预览
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作者 Agustin Cota-Coronado Lachlan H.Thompson N.Emmanuel Diaz-Martinez 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期255-256,共2页
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting 1% of the population over 55 years of age and up to 4% of the population over 80 years of age (Blesa et al., 2012). This prog... Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting 1% of the population over 55 years of age and up to 4% of the population over 80 years of age (Blesa et al., 2012). This progressive and neurodegenerative condition results from an excessive loss of dopaminergic neurons (50-70%) of the substantia nigra pars compacta, leading to a significant decrease in dopamine (DA) levels in the striatum and consequently a functional deterioration of motor circuity (Blesa et al., 2012;Nielsen et al., 2016). 展开更多
关键词 Parkinson's DISEASE STRIATUM NEURODEGENERATIVE
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Complement pathway in Alzheimer's pathology and retinal neurodegenerative disorders - the road ahead 预览
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作者 Mehdi Mirzaei Liting Deng +2 位作者 Veer Bala Gupta Stuart Graham Vivek Gupta 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期257-258,共2页
Chronic inflammation has increasingly been acknowledged as a hallmark feature of several progressive neurodegenerative disorders. Accruing evidence indicates that sustained inflammation compromises the core neuroprote... Chronic inflammation has increasingly been acknowledged as a hallmark feature of several progressive neurodegenerative disorders. Accruing evidence indicates that sustained inflammation compromises the core neuroprotective mechanisms underlying neural injury in Alzheimer's disease (AD) and retinal neurodegenerative disorders. 展开更多
关键词 PATHOLOGY NEURODEGENERATIVE mechanisms
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Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases 预览
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作者 Rubaiya Tabassum Na Young Jeong Junyang Jung 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期653-662,共10页
Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related disease... Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related diseases is oxidative stress.In recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully explored.The enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S.Previously,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related neurodegeneration.Due to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and Bcl-2.This review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome. 展开更多
关键词 3-mercaptopyruvate SULFURTRANSFERASE aging antioxidant cystathionineβ-synthase cystathionineγ-lyase GLUTATHIONE hydrogen sulfide NEURODEGENERATIVE disease oxidative stress reactive oxygen species
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Long-term adenosine A1 receptor activation-induced sortilin expression promotesα-synuclein upregulation in dopaminergic neurons 预览
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作者 Yun-Cheng Lv An-Bo Gao +7 位作者 Jing Yang Li-Yuan Zhong Bo Jia Shu-Hui Ouyang Le Gui Tian-Hong Peng Sha Sun Francisco S.Cayabyab 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期712-723,共12页
Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.However,the pathogenesis underlying long-term adenosine A1 receptor... Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.However,the pathogenesis underlying long-term adenosine A1 receptor activation-induced neurodegeneration remains unclear.In this study,rats were intraperitoneally injected with 5 mg/kg of the adenosine A1 receptor agonist N6-cyclopentyladenosine(CPA)for five weeks.The mobility of rats was evaluated by forced swimming test,while their cognitive capabilities were evaluated by Y-maze test.Expression of sortilin,α-synuclein,p-JUN,and c-JUN proteins in the substantia nigra were detected by western blot analysis.In addition,immunofluorescence staining of sortilin andα-synuclein was performed to detect expression in the substantia nigra.The results showed that,compared with adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine(5 mg/kg)+CPA co-treated rats,motor and memory abilities were reduced,surface expression of sortin andα-synuclein in dopaminergic neurons was reduced,and total sortilin and totalα-synuclein were increased in CPA-treated rats.MN9D cells were incubated with 500 nM CPA alone or in combination with 10μM SP600125(JNK inhibitor)for 48 hours.Quantitative real-time polymerase chain reaction analysis of sortilin andα-synuclein mRNA levels in MN9D cells revealed upregulated sortilin expression in MN9D cells cultured with CPA alone,but the combination of CPA and SP600125 could inhibit this expression.Predictions made using Jasper,PROMO,and Alibaba online databases identified a highly conserved sequence in the sortilin promoter that was predicted to bind JUN in both humans and rodents.A luciferase reporter assay of sortilin promoter plasmid-transfected HEK293T cells confirmed this prediction.After sortilin expression was inhibited by sh-SORT1,expression of p-JUN and c-JUN was detected by western blot analysis.Long-term adenosine A1 receptor activation levels upregulatedα-synuclein expression at the post-transcriptional level by affecting sort 展开更多
关键词 cognitive dysfunction DOPAMINERGIC neuron DYSKINESIA JNK/c-JUN pathway LONG-TERM adenosine A1 receptor activation neural regeneration NEURODEGENERATIVE diseases SORTILIN Α-SYNUCLEIN
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A mimetic peptide ofα2,6-sialyllactose promotes neuritogenesis 预览
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作者 Shuang-Xi Chen Jia-Hui He +3 位作者 Yong-Jian Mi Hui-Fan Shen Melitta Schachner Wei-Jiang Zhao 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1058-1065,共8页
Oxidative stress contributes to the pathogenesis of neurodegenerative diseases.With the aim to find reagents that reduce oxidative stress,a phage display library was screened for peptides mimicking a2,6-sialyllactose(... Oxidative stress contributes to the pathogenesis of neurodegenerative diseases.With the aim to find reagents that reduce oxidative stress,a phage display library was screened for peptides mimicking a2,6-sialyllactose(6'-SL),which is known to beneficially influence neural functions.Using Sambucus nigra lectin,which specifically binds to 6'-SL,we screened a phage display library and found a peptide comprising identical sequences of 12 amino acids.Mimetic peptide,reverse peptide and scrambled peptide were tested for inhibition of 6'-SL binding to the lectin.Indeed,lectin binding to 6'-SL was inhibited by the most frequently identified mimetic peptide,but not by the reverse or scrambled peptides,showing that this peptide mimics 6'-SL.Functionally,mimetic peptide,but not the reverse or scrambled peptides,increased viability and expression of neural cell adhesion molecule L1 in SK-N-SH human neuroblastoma cells,and promoted survival and neurite outgrowth of cultured mouse cerebellar granule neurons challenged by H_20_2-induced oxidative stress.The combined results indicate that the 6'-SL mimetic peptide promotes neuronal survival and neuritogenesis,thus raising hopes for the treatment of neurodegenerative diseases.This study was approved by the Medical Ethics Committee of Shantou University Medical College,China(approval No.SUMC 2014-004)on February 20,2014. 展开更多
关键词 central nervous system cerebellar granule neurons mimetic peptide neural cell adhesion molecule L1 NEURITOGENESIS neurodegenerative disease neuronal survival oxidative stress phage display Sambucus nigra lectin α2 6-sialyllactose
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Locus coeruleus-norepinephrine:basic functions and insights into Parkinson's disease 预览
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作者 Bilal Abdul Bari Varun Chokshi Katharina Schmidt 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1006-1013,共8页
The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine.Despite its small size,the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative ... The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine.Despite its small size,the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders.In this review,we discuss the physiology and anatomy of the locus coeruleus system and focus on norepinephrine's role in synaptic plasticity.We highlight Parkinson's disease as a disorder with motor and neuropsychiatric symptoms that may be understood as aberrations in the normal functions of locus coeruleus. 展开更多
关键词 CATECHOLAMINES copper neurodegenerative diseases NEUROMODULATION neuronal circuits neuropsychiatric symptoms NORADRENALINE synaptic plasticity
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Regional brain susceptibility to neurodegeneration:what is the role of glial cells? 预览
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作者 Andrea Beatriz Cragnolini Giorgia Lampitella +4 位作者 Assunta Virtuoso Immacolata Viscovo Fivos Panetsos Michele Papa Giovanni Cirillo 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期838-842,共5页
The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events.Early in the neurodegenerative process,glial cells... The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events.Early in the neurodegenerative process,glial cells (including astrocytes,microglial cells,and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction,metabolic decay,blood brain barrier dysfunction and energy impairment,boosting neuronal death.How these mechanisms might induce selective neuronal death in specific brain areas are far from being elucidated.The last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system,from development to synaptogenesis,neuronal homeostasis and integration into,highly specific neuro-glial networks.In this mini-review,we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of neurodegeneration.We report changes of transcriptional,genetic,morphological,and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration,providing evidence in experimental models of neurodegenerative disorders,including Parkinson’s and Alzheimer’s diseases.Understanding these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders. 展开更多
关键词 ASTROCYTES GLIAL cells microglia NEURODEGENERATIVE diseases NEUROINFLAMMATION Parkinson's disease reactive GLIOSIS selective neuronal degeneration
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Neurodegenerative diseases as proteinopathies-driven immune disorders 预览
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作者 Fausta Ciccocioppo Giuseppina Bologna +7 位作者 Eva Ercolino Laura Pierdomenico Pasquale Simeone Paola Lanuti Damiana Pieragostino Piero Del Boccio Marco Marchisio Sebastiano Miscia 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期850-856,共7页
In the pathophysiology of neurodegenerative disorders,the role of misfolded protein deposition leading to neurodegeneration has been primarily discussed.In the last decade,however,it has been proposed a parallel invol... In the pathophysiology of neurodegenerative disorders,the role of misfolded protein deposition leading to neurodegeneration has been primarily discussed.In the last decade,however,it has been proposed a parallel involvement of innate immune activation,chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by proteinopathies.New insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative disorders.Therefore,the hypothesis underlining the modulation of the innate and the adaptive immune system in the events linked to brain deposition of misfolded proteins could open new perspectives in the setting of specific immunotherapeutic strategies for the treatment of neurodegenerative diseases.Therefore,we have reviewed the pathogenic hypothesis in neurodegenerative pathologies,underling the links between the deposition of misfolded protein mechanisms and the immune activation. 展开更多
关键词 adaptive IMMUNITY CHOROID PLEXUS immunotherapy INNATE IMMUNITY NEURODEGENERATIVE diseases NEUROINFLAMMATION proteinopathies
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自噬与糖尿病视神经病变
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作者 王立 宋鄂 《国际眼科纵览》 2019年第3期175-179,共5页
自噬是细胞内物质的降解途径之一,介导细胞内蛋白和部分细胞器的降解,对维持神经元内环境稳态具有重要的生理功能。自噬是糖尿病视神经病变(diabetic optic neuropathy,DON)治疗的潜在靶点。高糖可通过调节mTOR信号通路,影响DON发生发展... 自噬是细胞内物质的降解途径之一,介导细胞内蛋白和部分细胞器的降解,对维持神经元内环境稳态具有重要的生理功能。自噬是糖尿病视神经病变(diabetic optic neuropathy,DON)治疗的潜在靶点。高糖可通过调节mTOR信号通路,影响DON发生发展;同时自噬在DON的转归过程中发挥双刃剑作用,其对于DON发挥的作用是保护还是加重损伤尚不明确。体内氧化应激、多元醇等代谢途径对自噬过程进行调控,利用自噬作用对DON进行治疗具有重要意义。 展开更多
关键词 自噬 糖尿病视神经病变 神经变性疾病 信号通路
Can leukocyte telomere shortening be a possible biomarker to track Huntington’s disease progression? 预览
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作者 Elide Mantuano Martina Peconi Daniela Scarabino 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1709-1710,共2页
Huntington's disease (HD): HD is an autosomal dominant neurodegenerative disease, caused by a CAG trinucleotide repeat expansion in the first exon of the HTT gene encoding the huntingtin protein. The mutant protei... Huntington's disease (HD): HD is an autosomal dominant neurodegenerative disease, caused by a CAG trinucleotide repeat expansion in the first exon of the HTT gene encoding the huntingtin protein. The mutant protein contains an expanded polyglutamine sequence that confers a toxic gain-of-function and causes neurodegeneration. Moreover, several studies indicate that loss of the normal protein beneficial functions, contribute to the pathology (Schulte and Littleton 2011). Triplet expansion over 40 repeats are fully penetrant and invariably lead to manifest HD in the fourth or fifth decade of life. 展开更多
关键词 Huntington's disease(HD) NEURODEGENERATIVE DISEASE FIFTH decade of life
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Normal tension glaucoma: from the brain to the eye or the inverse? 预览
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作者 Hui-Jun Zhang Xue-Song Mi Kwok-Fai So 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1845-1850,共6页
Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in whi... Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in which the patient’s intraocular pressure is within the normal range, but the patient experiences typical glaucomatous changes. However, increasing evidence has challenged the traditional pathophysiological view of normal tension glaucoma, which is based only on intraocular pressure, and breakthroughs in central nervous system imaging may now greatly increase our knowledge about the mechanisms underlying normal tension glaucoma. In this article, we review the latest progress in understanding the pathogenesis of normal tension glaucoma and in developing imaging techniques to detect it, to strengthen the appreciation for the connection between normal tension glaucoma and the brain. 展开更多
关键词 nerve REGENERATION normal tension GLAUCOMA open angle GLAUCOMA NEURODEGENERATIVE diseases visual field CEREBROSPINAL fluid pressure IMAGING techniques pathogenesis magnetic resonance IMAGING diffusion TENSOR IMAGING metabolic changes neural REGENERATION
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Neuromodulatory effects of ethyl acetate fraction of Zingiber officinale Roscoe extract in rats with lead-induced oxidative stress
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作者 Mary Abiola Okesola Basiru Olaitan Ajiboye +1 位作者 Babatunji Emmanuel Oyinloye Oluwafemi Adeleke Ojo 《结合医学学报:英文版》 CAS CSCD 2019年第2期125-131,共7页
Objective: This study investigated the ameliorative potential of Zingiber officinale Roscoe extract against lead-induced brain damage in rats. Methods: Thirty male rats were divided into 5 groups of 6 rats each. Lead-... Objective: This study investigated the ameliorative potential of Zingiber officinale Roscoe extract against lead-induced brain damage in rats. Methods: Thirty male rats were divided into 5 groups of 6 rats each. Lead-acetate toxicity was induced by intraperitoneal injection (10 mg/kg body weight (b.w.)) in Groups B-E. Group A (control) and Group B (lead-acetate) were left untreated;vitami n C (200 mg/kg b.w.) was ad mi nistered to Group C;ethyl acetate fraction from Z. officinale extract (200 and 100 mg/kg b.w.) was administered to Group D and E by oral gavage once daily for 7 days. Changes in the content of some key marker enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), epinephrine, dopamine, Na^+/K^+-ATPase, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as malonaldehyde (MDA) levels were determined in serum. Results: Exposure to lead acetate resulted in a significant decrease (P< 0.05) in the activities of BChE, AChE, Na^+/K^+-ATPase, SOD, CAT and GPx with a corresponding increase in the levels of MDA, xanthine oxidase, epinephrine, dopamine and MAO relative to the control group. Levels of all disrupted parameters were alleviated by co-admi nistration of Z. officinale fraction and by the stan da rd drug, vitamin C. Conclusion: These results suggest that ethyl acetate fraction of Z. officinale extract attenuates leadinduced brain damage and might have therapeutic potential as a supplement that can be applied in lead pois on ing. 展开更多
关键词 ZINGIBER officinale ACETYLCHOLINESTERASE MONOAMINE OXIDASE Na^+/K^+-ATPase LEAD acetate NEURODEGENERATIVE disorders
Potential applications of artemisinins in ocular diseases
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作者 Bing-Wen Lu Li-Ke Xie 《国际眼科杂志:英文版》 SCIE CAS 2019年第11期1793-1800,共8页
Artemisinin, also named qinghaosu, is a family of sesquiterpene trioxane lactone originally derived from the sweet wormwood plant(Artemisia annua), which is a traditional Chinese herb that has been universally used as... Artemisinin, also named qinghaosu, is a family of sesquiterpene trioxane lactone originally derived from the sweet wormwood plant(Artemisia annua), which is a traditional Chinese herb that has been universally used as anti-malarial agents for many years. Evidence has accumulated during the past few years which demonstrated the protective effects of artemisinin and its derivatives(artemisinins) in several other diseases beyond malaria, including cancers, autoimmune disorders, inflammatory diseases, viral and other parasiterelated infections. Recently, this long-considered antimalarial agent has been proved to possess anti-oxidant, anti-inflammatory, anti-apoptotic and anti-excitotoxic properties, which make it a potential treatment option for the ocular environment. In this review, we first described the overview of artemisinins, highlighting the activity of artemisinins to other diseases beyond malaria and the mechanisms of these actions. We then emphasized the main points of published results of using artemisinins in targeting ocular disorders, including uveitis, retinoblastoma, retinal neurodegenerative diseases and ocular neovascularization. To conclude, we believe that artemisinins could also be used as a promising therapeutic drug for ocular diseases, especially retinal vascular diseases in the near future. 展开更多
关键词 ARTEMISININS UVEITIS RETINOBLASTOMA retinal neurodegenerative diseases ocular neovascularization
Characteristics and advantages of adenoassociated virus vector-mediated gene therapy for neurodegenerative diseases 预览
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作者 Yuan Qu Yi Liu +2 位作者 Ahmed Fayyaz Noor Johnathan Tran Rui Li 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第6期931-938,共8页
Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons,even leading to the permanent loss of function.Gene therapy via gene replacement or ge... Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons,even leading to the permanent loss of function.Gene therapy via gene replacement or gene correction provides the potential for transformative therapies to delay or possibly stop further progression of the neurodegenerative disease in affected patients.Adeno-associated virus has been the vector of choice in recent clinical trials of therapies for neurodegenerative diseases due to its safety and efficiency in mediating gene transfer to the central nervous system.This review aims to discuss and summarize the progress and clinical applications of adeno-associated virus in neurodegenerative disease in central nervous system.Results from some clinical trials and successful cases of central neurodegenerative diseases deserve further study and exploration. 展开更多
关键词 nerve REGENERATION central nervous system gene therapy NEURODEGENERATIVE DISEASE viral vector ADENO-ASSOCIATED virus Alzheimer’s DISEASE Parkinson’s DISEASE Huntington’s DISEASE amyotrophic lateral SCLEROSIS spinal muscular atrophy neural REGENERATION
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Modeling of Neurodegenerative Diseases Using Discrete Chaotic Systems
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作者 Payam Sadeghi Shabestari Zahra Rostami +1 位作者 Viet-Thanh Pham Fawaz E.Alsaadi 《理论物理通讯:英文版》 SCIE CAS CSCD 2019年第10期1241-1245,共5页
Parkinson’s and Huntington’s diseases are two of the most common neurodegenerative disorders. Tremor,muscle stiffness, and slowness of movement are symptoms of Parkinson’s disease. The symptoms of Huntington’s dis... Parkinson’s and Huntington’s diseases are two of the most common neurodegenerative disorders. Tremor,muscle stiffness, and slowness of movement are symptoms of Parkinson’s disease. The symptoms of Huntington’s disease are severe reduction in muscle control, emotional disturbance, and pathological disorders in brain cells. These diseases are caused by destruction of the cells that secrete a substance called dopamine. In this paper, a new discrete chaotic system is introduced, which can mimic the brain’s behavior for neurodegenerative diseases such as Parkinson, Huntington, and Hypokinesia. This system is described based on the similarity between the brain’s behavior in normal and abnormal conditions and the chaotic systems. Bifurcation analysis is carried out with respect to different parameters, providing full spectrum of the behavior for different parameter values. Our results can be used to mathematically study the mechanisms behind these diseases. 展开更多
关键词 NEURODEGENERATIVE DISEASES PARKINSON HUNTINGTON Hypokinesia CHAOS BIFURCATION
Neuroprotective effect of Neuro-EPO in neurodegenerative diseases:“Alea jacta est” 预览
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作者 Ramón Rama Fernando Garzón +2 位作者 Yamila Rodríguez-Cruz Tangui Maurice Julio-César García-Rodríguez 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1519-1521,共3页
Our common home,planet Earth,is inhabited by more than 7 billion human beings.The average life expectancy currently estimated for men is~69 years,with strong differences among countries.Currently,neurodegenerative dis... Our common home,planet Earth,is inhabited by more than 7 billion human beings.The average life expectancy currently estimated for men is~69 years,with strong differences among countries.Currently,neurodegenerative diseases are currently the leading cause of death and disability worldwide.In clinical use and neuroscience research,a solution for an effective diagnosis is in progress,but a prophylactic treatment to counteract this long-lasting plague for humanity is still unidentified. 展开更多
关键词 OUR common HOME NEURODEGENERATIVE STILL unidentified
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Adipose-derived stem cell conditioned medium for the treatment of amyotrophic lateral sclerosis:pre-clinical evidence and potential for clinical application 预览
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作者 Chandler L.Walker 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1522-1524,共3页
Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that causes death of upper and lower motor neurons(MNs)in the central nervous system(CNS).The disease afflicts most people in pr... Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that causes death of upper and lower motor neurons(MNs)in the central nervous system(CNS).The disease afflicts most people in prime periods of productivity in life,and it is estimated approximately 200,000 individuals in the United States live with ALS and any given time.Though a significant percentage of individuals with ALS have a genetic or hereditary form of the disease,the majority are sporadic cases with unknown etiologies.Regardless of cause,onset and progression of the disease is similar in all ALS patients,with minor initial outward symptoms followed by rapid deterioration of motor function leading to widespread paralysis,respiratory dysfunction and death.Despite the distressing and debilitating nature of ALS,no cures and limited potential treatment options exist.Therefore,identifying targets for effective therapy leading to delayed disease progression,increased quality of life,and extended lifespan are critical areas of investigation.In addition,identifying biomarkers of disease progression is incredibly important as diagnosis often occurs once the disease is in late stages and lifespan is only an average of 3–5 years after diagnosis.As the cellular and physiological processes known to influence or be involved in ALS are numerous,the complexity of the disease is a major detriment in developing effective therapies.Aside from the ubiquitous death of MNs,inflammatory and immunologic response in the spinal cord,brain and target muscles,and signal pathway changes that precede or are induced by MN death have been identified at multiple stages of disease progression. 展开更多
关键词 Amyotrophic LATERAL devastating PROGRESSIVE NEURODEGENERATIVE disease PROGRESSION
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Brain Banking for Research into Neurodegenerative Disorders and Ageing
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作者 Claire E.Shepherd Holly Alvendia Glenda M.Halliday 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第2期283-288,共6页
Advances in cellular and molecular biology underpin most current therapeutic advances in medicine.Such advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens. It is beco... Advances in cellular and molecular biology underpin most current therapeutic advances in medicine.Such advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens. It is becoming increasingly evident that greater access to human brain tissue is necessary to understand both the cellular biology of these diseases and their variation. Research in these areas is vital to the development of viable therapeutic options for these currently untreatable diseases. The development and coordination of human brain specimen collection through brain banks is evolving. This perspective article from the Sydney Brain Bank reviews data concerning the best ways to collect and store material for different research purposes. 展开更多
关键词 BRAIN BANKING BRAIN DONATION NEURODEGENERATIVE DISEASES Human BRAIN TISSUE processing
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