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产后抑郁患者血清激素和NE、5-HT的相互关系及与防御机制成熟程度的关联研究 预览
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作者 聂波 《标记免疫分析与临床》 CAS 2019年第3期412-415,共4页
目的分析产后抑郁患者防御方式与血清孕酮、NE以及5-HT水平之间的关联。方法研究选取本院分娩并随访确诊为产后抑郁症的患者98例纳入研究为实验组,随机选择同期参与评估的、SDS总分<41分的产妇32例作为对照组;实验组采用防御方式量表... 目的分析产后抑郁患者防御方式与血清孕酮、NE以及5-HT水平之间的关联。方法研究选取本院分娩并随访确诊为产后抑郁症的患者98例纳入研究为实验组,随机选择同期参与评估的、SDS总分<41分的产妇32例作为对照组;实验组采用防御方式量表(DSQ)根据防御方式不同再次分为三组(不成熟防御机制组30例;成熟防御机制组35例;中间型防御机制组33例),检测产妇孕酮、NE以及5-HT水平,并进行比较,讨论与产后抑郁患者三种防御方式之间的关联。采用SPSS19.0统计软件分析处理数据。结果三组患者基本特征未见差别,充分可比,P>0.05。研究中三种防御机制的患者产前孕酮、NE以及5-HT水平在不同防御机制组中差别均未见统计学意义,P>0.05;产后三个指标水平均低于产前水平,差别均有统计学意义,P<0.05;且产后的孕酮、NE以及5-HT水平在不成熟防御机制组患者中水平最低,差别有统计学意义,P<0.05;分析产后血清孕酮、NE以及5-HT水平与防御机制之间的相关性,可见产后孕酮水平、NE以及5-HT水平与防御机制的逐渐成熟之间成正相关,差异均有统计学意义,P<0.05。继续进一步分析三个指标之间的相互关联,可见分别均呈正相关,也均有统计学意义,P<0.05。结论产后抑郁的患者存在产后血清孕酮、NE以及5-HT水平的下降,且防御机制越不成熟,三个指标的水平相对越低。血清孕酮、NE以及5-HT水平与产后抑郁的发生存在潜在关联。 展开更多
关键词 产后抑郁 防御方式 孕酮 NE 5-HT
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口腔扁平苔藓疾病与心理人格生活质量之间的关系 预览
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作者 张梅华 缪羽 昭日格图 《实用口腔医学杂志》 CAS CSCD 北大核心 2019年第3期436-438,共3页
目的:探讨精神应激与人类口腔扁平苔藓疾病(OLP)的关系。方法:采用焦虑自评量表(SAS)和抑郁自评量表(SDS)对OLP患者(n=50)和正常人群(n=50)进行焦虑、抑郁情况进行评估,同时检测两人群中血清相关指标,并进行2组比较。结果:OLP患者组和... 目的:探讨精神应激与人类口腔扁平苔藓疾病(OLP)的关系。方法:采用焦虑自评量表(SAS)和抑郁自评量表(SDS)对OLP患者(n=50)和正常人群(n=50)进行焦虑、抑郁情况进行评估,同时检测两人群中血清相关指标,并进行2组比较。结果:OLP患者组和对照组性别和年龄无统计学差异(P>0.05);病例组SAS及SDS得分均高于对照组,5-HT水平、NE水平低于对照组(P<0.05), ACTH水平、CORT水平高于对照组(P<0.05)。结论:OLP影响了患者的口腔健康,患者存在焦虑和抑郁等心理障碍,应注重心理疏导和治疗。 展开更多
关键词 口腔黏膜扁平苔藓(OLP) 焦虑自评量表(SAS) 抑郁自评量表(SDS) 5-HT NE ACTH CORT
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Wet-Cupping Is Effective on Persistent Nonspecific Low Back Pain: A Randomized Clinical Trial
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作者 Mohsen Mardani-Kivi Reza Montazar +1 位作者 Mohammad Azizkhani Keyvan Hashemi-Motlagh 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第7期502-506,共5页
Objective: To compare the possible effects of wet-cupping therapy with conventional therapy on persiste nt non specific low back pain (PNSLBP). Methods: In this ran domized clinical trial, 180 participa nts with the m... Objective: To compare the possible effects of wet-cupping therapy with conventional therapy on persiste nt non specific low back pain (PNSLBP). Methods: In this ran domized clinical trial, 180 participa nts with the mean age of 45 ±10 years old, who had been suffering from PNSLBP were randomly assigned to wet-cupping and conventional groups using random blook. The wet-cupping group was treated with two separate sessions (4 weeks in total) on the inter-scapular and sacrum area. In the conventional group, patients were conservatively treated using rest (6 weeks) and oral medicati ons (3 weeks). The primary and the sec on dary outcome were the qua ntity of disability using Oswestry Disability Index (ODI), and pain intensity using Visual Analogue Scale (VAS), respectively. Results: There was no significant difference in demographic characteristics (age, gender, and body mass index) between the two groups (P>0.05). Therapeutic effect of wet-cupping therapy was comparable to conventional treatment in the 1st month follow-up visits (P<0.05). The functional outcomes of wet-cupping at the 3rd and 6th month visits were significantly increased compared to the conventional group. Final ODI scores in the wet-cupping and conventional groups were 16.7 ±5.7 and 22.3 ±4.5, respectively (P<0.01). Conclusion: Wet-cupping may be a proper method to decrease PNSLBP without any conventional treatment. The therapeutic effects of wet-cupping can be longer lasting than conventional therapy.(Registration No. IRCT2013021672741). 展开更多
关键词 low back pain chronic wet-cupping therapy traditi onal MEDICI NE Chin ese MEDICI NE alter native medicine CONSERVATIVE treatment randomized clinical trial
5-HT、NE、DA联合检测对抑郁症患者的应用意义 预览
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作者 葛明广 《中外女性健康研究》 2019年第9期3-4,共2页
目的:探究和分析5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)在抑郁症患者中的表达及意义。方法:选取本院收治的45例抑郁症患者为研究组,另外选取45例正常人为对照组,测量两组研究对象的5-HT、NE、DA含量。结果:研究组患者的5-HT、NE... 目的:探究和分析5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)在抑郁症患者中的表达及意义。方法:选取本院收治的45例抑郁症患者为研究组,另外选取45例正常人为对照组,测量两组研究对象的5-HT、NE、DA含量。结果:研究组患者的5-HT、NE、DA低于对照组(P<0.05)。且含量越低,临床症状越严重,抑郁症患者的病情越严重,自杀倾向愈突出。结论:5-HT、NE、DA在抑郁症患者中的表达较少,含量较低,低于正常人,且研究发现,含量越低,临床症状越严重,5-HT、NE、DA在抑郁症患者中的表达及意义反应,具有较好的临床参考价值,可以进一步地研究其价值,更好地为临床治疗提供研究佐证。 展开更多
关键词 5-HT NE DA 抑郁症患者 表达
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表示心理安慰的“有NP呢”构式 预览
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作者 唐贤清 张言军 《语言科学》 CSSCI 北大核心 2019年第3期292-298,共7页
“有NP呢”是现代汉语中一种使用频率较高且表达功能较为多样的构式。在对话语境中,针对受话人所表现出来的担忧或焦虑情绪,说话人常常使用“有NP呢”去安抚受话人。这一构式的形成是在言语交际中由于表达的需要从传统的语法构式中逐渐... “有NP呢”是现代汉语中一种使用频率较高且表达功能较为多样的构式。在对话语境中,针对受话人所表现出来的担忧或焦虑情绪,说话人常常使用“有NP呢”去安抚受话人。这一构式的形成是在言语交际中由于表达的需要从传统的语法构式中逐渐发展而来的。在表达中,“有NP呢”构式具有“言简而意丰”和“委婉而含蓄”等语用特征。 展开更多
关键词 心理安慰 构式 “有” “呢”
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Timming of Lithospheric Extension in Northeastern China:Evidence from the Late Mesozoic Nianzishan A-Type Granitoid Complex
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作者 Jinhua Qin Cui Liu +1 位作者 Yuchuan Chen Jinfu Deng 《地球科学学刊:英文版》 SCIE CAS CSCD 2019年第4期689-706,共18页
New zircon U-Pb dates obtained by laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS),whole-rock geochemical data and Sm-Nd and Rb-Sr isotopic data are presented for miarolitic alkaline granites,por... New zircon U-Pb dates obtained by laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS),whole-rock geochemical data and Sm-Nd and Rb-Sr isotopic data are presented for miarolitic alkaline granites,porphyritic syenite and rhyolites of the Nianzishan A-Type granitoid complex(NAGC)in the Great Xing'an Range-Songliao Basin in Northeast(NE)China.New crystallization ages of 112.95±0.93 and 114.1±1.71 Ma for granite and 118.6±0.51 Ma for porphyritic syenite were determined by high-precision LA-ICP-MS.The εNd(t)of the rocks range from +1.85 to+2.06,with Nd model ages(T(DM1))from 671 to 821 Ma,indicating that the NAGC originated from juvenile source rocks and exhibits geochemical characteristics of A1-and A-Type granite which formed in an extensional setting.We attribute the magmatism to regional extension and lithospheric thinning caused by the subduction of the western Pacific Plate about 120 to 100 Ma. 展开更多
关键词 A-TYPE granitee new ZIRCON UU-Pb ZIRCON agees NE China LITHOSPHERIC exxtension
Assembly of carbon nanodots in graphene-based composite for flexible electro-thermal heater with ultrahigh efficiency
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作者 Xin Meng Tianxing Chen +6 位作者 Yao Li Siyuan Liu Hui Pan Yuning Ma Zhixin Chen Yanping Zhang Shenmin Zhu 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第10期2498-2508,共11页
A high-efficiency electro-thermal heater requires simultaneously high electrical and thermal conductivities to generate and dissipate Joule heat efficiently.A low in put voltage is essential to en sure the heaters saf... A high-efficiency electro-thermal heater requires simultaneously high electrical and thermal conductivities to generate and dissipate Joule heat efficiently.A low in put voltage is essential to en sure the heaters safe applications.However,the low voltage gen erally leads to low saturated temperature and heati ng rate and hence a low thermal efficie ncy.How to reduce the in put voltage while maintai ning a high electro-thermal efficiency is still a challenge.Herein,a highly electrical and thermal conductive film was 8nstructed using a graphene-based composite which has an internal three-dimensional(3D)conductive network.In the 3D framework,cellulose nanocrystalline(CNC)phase with chiral liquid crystal manner presents in the form of alig ned helix betwee n the graphe ne oxide(GO)layers.Carbon nano dots(CDs)are assembled泊side the composite as con ductive nano fillers.Subseque nt an neali ng and compressi on results in the formati on of the assembled GO-CNC-CDs film.The carb on ized CNC nano rods(CNR)with the helical alignment act as irrplane and through-pla ne conn ecti ons of n eighbori ng reduced GO(rGO)nano sheets,forming a con ductive network in the composite film.The CDs with ultrafast electr ons tran sfer rates provide additi onal electro ns and phonons tran sport paths for the composite.As a result,the obtai ned graphe ne・based composite film(rGO-CNR-CDs)exhibited a high thermal conductivity of 1,978.6 W m^-1·K^-1 and electrical conductivity of 2,053.4 S·cm^-1,respectively.The composite film showed an outstanding electro-thermal heating efficiency with the saturated temperature of 315℃and maximum heating rate of 44.9℃·s^-1 at a very low in put voltage of 10 V.The freestandi ng graphe ne composite film with the delicate nano structure desig n has a great pote ntial to be integrated into electro-thermal devices. 展开更多
关键词 graphe ne film carbon nano dots self-assembly electro-thermal heater three-dime nsional(3D)conductive framework
系统性痰液分析技术在评估COPD病情进展中的意义 预览
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作者 王杰 周向东 +3 位作者 李琪 黄华萍 刘峰 覃英娇 《临床肺科杂志》 2019年第6期974-977,共4页
目的了解慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)病情不同阶段痰液理化特性及炎性因子弹性蛋白酶(neutrophile elastase,NE)、人白细胞弹性蛋白酶抑制因子(elafin)含量的演变,探究其在COPD病情评估中的价值。方... 目的了解慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)病情不同阶段痰液理化特性及炎性因子弹性蛋白酶(neutrophile elastase,NE)、人白细胞弹性蛋白酶抑制因子(elafin)含量的演变,探究其在COPD病情评估中的价值。方法收集20例COPD患者临床缓解期及急性加重期的痰液标本,观察痰液外观性状的差异;采用常规理化分析和免疫荧光定量方法,检测并分析痰液的粘度,痰液中粘蛋白、多糖、硫酸基、NE以及elafin的含量,同时计算痰液炎性损伤因素水平、抗损伤因素水平及损伤指数。结果COPD组痰液理化指标及NE含量均较正常人明显增高(P<0.01),elafin含量均较正常人降低。COPD组急性加重期与临床缓解期相比,痰液外观呈粘液脓性改变,痰液理化指标及NE含量升高(P<0.05),elafin含量降低(P<0.05)。COPD组痰液粘度与粘蛋白、多糖、硫酸基、NE呈正相关,与elafin呈负相关,急性加重期相关度更高。结论COPD病情的进展伴随痰液理化性质的恶化及炎性损伤因素/抗损伤因素水平的失衡,痰液分析在COPD患者病情评估中起重要作用。 展开更多
关键词 痰液分析 慢性阻塞性肺疾病 NE ELAFIN
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Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery
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作者 Abdullah A.Ghawanmeh Gomaa A.M.Ali +2 位作者 H.Algarni Shaheen M.Sarkar Kwok Feng Chong 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期973-990,共18页
Graphene oxide (GO) possesses excellent mechanical strength,biocompatibility,colloidal stability,large surface area and high adsorption capability.It has driven to cancer nanotechnology to defeat cancer therapy obstac... Graphene oxide (GO) possesses excellent mechanical strength,biocompatibility,colloidal stability,large surface area and high adsorption capability.It has driven to cancer nanotechnology to defeat cancer therapy obstacles,via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier,and controllable release of anticancer drugs.Specifically,the surface of GO affords π-π stacking and hydrophilic interactions with anticancer drugs.Additionally,modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability,drug loading,and target delivery.In this review,GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies,preparation methods,the model drug,polymer conjugation and modification with targeting ligands.Moreover,swelling kinetics,drug release profile and biological activity in vivo and in vitro are discussed.The biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio interfaces.Apart from that,the clinical potential of GO based hydrogels and its major challenges are addressed in detail.Finally,this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug delivery.It is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels,such as large surface area,chemical purity,high loading capacity of drug,chemical stability,and the nature of lipophilic for cell membrane penetration. 展开更多
关键词 graphe ne oxide cancer nan otechnology HYDROGEL NANOCARRIER drug delivery
TE和NE两种不同化疗方案治疗乳腺癌手术患者临床疗效及毒副反应分析 预览
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作者 柳燕 董扬扬 +1 位作者 李新宇 林文集 《四川解剖学杂志》 2019年第1期49-50,共2页
目的旨在探讨TE(多西紫杉醇联合表柔比星)和NE(长春瑞滨联合表柔比星)两种不同化疗方案对乳腺癌手术患者临床疗效及毒副反应。方法选取我院2016年5月~2017年7月收治的62例乳腺癌患者作为研究对象,收集患者临床资料进行回顾性分析。根据... 目的旨在探讨TE(多西紫杉醇联合表柔比星)和NE(长春瑞滨联合表柔比星)两种不同化疗方案对乳腺癌手术患者临床疗效及毒副反应。方法选取我院2016年5月~2017年7月收治的62例乳腺癌患者作为研究对象,收集患者临床资料进行回顾性分析。根据患者手术前化疗方案的不同,将患者分为TE组(n=31)和NE组(n=31)。比较两组患者治疗的临床效果及毒副反应情况。结果 TE组患者临床有效率为80.64%,NE组患者临床有效率为74.19%,两组患者临床有效率比较,差异无统计学意义(P>0.05);两组患者治疗过程中,主要以胃肠道反应、脱发、外周静脉炎、中线粒细胞减少为毒副反应,TE组患者外周静脉炎发生率为38.70%,明显低于NE组67.74%(P<0.05),两组患者胃肠道反应、脱发、中线粒细胞减少等毒副反应发生率比较无明显差异(P>0.05)。结论 TE和NE两种不同化疗方案治疗乳腺癌手术患者临床疗效相当,但NE组患者外周静脉炎发生率较高,在治疗过程中要加强护理,避免药物外渗。 展开更多
关键词 TE NE 乳腺癌 手术患者 临床疗效 毒副反应
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Anti-nociceptive Effect of Patchouli Alcohol: Involving Attenuation of Cyclooxygenase 2 and Modulation of Mu-Opioid Receptor
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作者 YU Xuan WANG Xin-pei +5 位作者 YAN Xiao-jin JIANG Jing-fei LEI Fan XING Dong-ming GUO Yue-ying DU Li-jun 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第6期454-461,共8页
Objective: To explore the anti-nociceptive effect of patchouli alcohol(PA), the essential oil isolated from Pogostemon cablin(Blanco) Bent, and determine the mechanism in molecular levels. Methods: The acetic acid-ind... Objective: To explore the anti-nociceptive effect of patchouli alcohol(PA), the essential oil isolated from Pogostemon cablin(Blanco) Bent, and determine the mechanism in molecular levels. Methods: The acetic acid-induced writhing test and formalin-induced plantar injection test in mice were employed to con?rm the effect in vivo. Intracellular calcium ion was imaged to verify PA on mu-opioid receptor(MOR). Cyclooxygenase 2(COX2)and MOR of mouse brain were expressed for determination of PA’s target. Cellular experiments were carried out to find out COX2 and MOR expression induced by PA. Results: PA significantly reduced latency period of visceral pain and writhing induced by acetic acid saline solution(P<0.01) and allodynia after intra-plantar formalin(P<0.01) in mice. PA also up-regulated COX2 mRNA and protein(P<0.05) with a down-regulation of MOR(P<0.05) both in in vivo and in vitro experiments, which devote to the analgesic effect of PA. A decrease in the intracellular calcium level(P<0.05) induced by PA may play an important role in its anti-nociceptive effect.PA showed the characters of enhancing the MOR expression and reducing the intracellular calcium ion similar to opioid effect. Conclusions: Both COX2 and MOR are involved in the mechanism of PA’s anti-nociceptive effect,and the up-regulation of the receptor expression and the inhibition of intracellular calcium are a new perspective to PA’s effect on MOR. 展开更多
关键词 Chinese MEDICI ne patchouli alcohol an algesic EFFECT mu-opioid receptor cyclooxyge nase 2
Characteristics of Early Cretaceous wildfires in peat-forming environment, NE China
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作者 Shuai Wang Long-Yi Shao +2 位作者 Zhi-Ming Yan Ming-Jian Shi Yun-He Zhang 《古地理学报:英文版》 CSCD 2019年第3期238-250,共13页
Inertinite maceral compositions in coals from the Early Cretaceous Erlian, Hailar, and Sanjiang Basins in NE China are analyzed in order to reveal palaeowildfire events and palaeoclimate variations. Although huminite ... Inertinite maceral compositions in coals from the Early Cretaceous Erlian, Hailar, and Sanjiang Basins in NE China are analyzed in order to reveal palaeowildfire events and palaeoclimate variations. Although huminite is the dominant maceral group in the studied basins, the inertinite group, as a byproduct of palaeowildfires, makes up a considerable proportion. Occurrence of inertinite macerals indicates that wildfires were widespread and frequent,and supports the opinion that the Early Cretaceous was a "high-fire" interval. Inertinite contents vary from 0.2% to 85.0%, mostly within the range of 10%–45%, and a model-based calculation suggests that the atmospheric oxygen levels during the Aptian and Albian(Early Cretaceous) were around 24.7% and 25.3% respectively. Frequent fire activity during Early Cretaceous has been previously related to higher atmospheric oxygen concentrations. The inertinite reflectance, ranging from 0.58%Ro to 2.00%Ro, indicates that the palaeowildfire in the Early Cretaceous was dominated by ground fires, partially reaching-surface fires. These results further support that the Cretaceous earliest angiosperms from NE China were growing in elevated O2 conditions compared to the present day. 展开更多
关键词 INERTINITE Coal Wildfire Palaeo-atmospheric oxygen level ANGIOSPERM Early Cretaceous NE China
脑卒中后睡眠障碍患者早期血清5-HT、NE水平的变化及其临床意义 预览
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作者 李红闪 杨凡 +3 位作者 赵婧 李轩 魏书艳 万莉 《世界睡眠医学杂志》 2019年第5期667-669,共3页
目的:探讨脑卒中后睡眠障碍(PSSD)患者早期血清5-HT、NE水平的变化及其临床意义。方法:选取2016年8月至2017年3月保定市第一中心医院神经内三科收治的PSSD患者50例(观察组)和健康体检者50例(对照组)作为研究对象,应用ELISA法检测2组血清... 目的:探讨脑卒中后睡眠障碍(PSSD)患者早期血清5-HT、NE水平的变化及其临床意义。方法:选取2016年8月至2017年3月保定市第一中心医院神经内三科收治的PSSD患者50例(观察组)和健康体检者50例(对照组)作为研究对象,应用ELISA法检测2组血清5-HT、NE含量,分析其变化趋势与病情严重程度的关系。结果:PSSD患者早期血清5-HT、NE水平明显低于正常对照组,中重度PSSD患者血清5-HT、NE水平明显低于轻度PSSD患者,差异有统计学意义(P<0.05)。结论:PSSD患者的血清5-HT、NE水平变化可反映病情严重程度,对临床上PSSD病情的评估及治疗具有重要意义。 展开更多
关键词 脑卒中 睡眠障碍 5-羟色胺 去甲肾上腺素
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生长期肉鸡玉米和玉米干酒糟及其可溶物的代谢能和净能评定 预览
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作者 班志彬 杨华明 +7 位作者 于维 宋坤烊 张莹 李立佳 郎朝丽 梁浩 苏斯瑶 闫晓刚 《动物营养学报》 CAS CSCD 北大核心 2019年第2期792-800,共9页
本研究采用禽用开放式呼吸测热装置进行能量代谢试验,共2个试验,分别测定玉米和玉米干酒糟及其可溶物(DDGS)的代谢能和净能。试验1和试验2各选用25~28日龄ROSS308雄鸡180只,采用近似拉丁方设计,配制2种基础饲粮和4种待测饲粮,每种饲粮6... 本研究采用禽用开放式呼吸测热装置进行能量代谢试验,共2个试验,分别测定玉米和玉米干酒糟及其可溶物(DDGS)的代谢能和净能。试验1和试验2各选用25~28日龄ROSS308雄鸡180只,采用近似拉丁方设计,配制2种基础饲粮和4种待测饲粮,每种饲粮6个重复,每个重复10只鸡。试验1中待测玉米(玉米吉粳511、吉农823)以40%比例替代玉米-豆粕型基础饲粮。试验2中待测玉米DDGS(中粮玉米DDGS、吉燃玉米DDGS)以30%比例替代玉米-豆粕型基础饲粮中能量部分。试验1和试验2各分3期,每期31 d,每期试验中使用雄性鸡雏60只,随机分为3组,每组20只,试验鸡第1~21天在鸡舍内分组饲养,第21天称重后从每组中选择4只试验鸡,分别放入呼吸测热装置的代谢室内,测定气体交换和排泄物总量,适应3d、呼吸测热3 d、绝食测热3 d,呼吸测热的同时进行消化代谢试验。结果表明:1)试验1中,玉米待测饲粮的表观代谢能、代谢能摄入量、沉积能及净能显著高于基础饲粮(P<0.05);平均日增重、产热量、绝食产热量、呼吸熵及净能/表观代谢能未受待测饲粮的影响(P>0.05)。2)试验2中,玉米DDGS待测饲粮的平均日采食量、代谢能摄入量及产热量显著高于基础饲粮(P<0.05);待测饲粮的表观代谢能、沉积能、净能及净能/表观代谢能显著低于基础饲粮(P<0.05);平均日增重、绝食产热量、呼吸熵未受待测饲粮的影响(P>0.05)。干物质基础的玉米吉粳511、吉农823对于ROSS 308雄鸡(25~28日龄)的表观代谢能分别为13.79和13.64 MJ/kg,净能分别为10.77和10.57 MJ/kg。干物质基础的中粮玉米DDGS、吉燃DDGS对于ROSS 308雄鸡(25~28日龄)表观代谢能分别为10.37和10.74 MJ/kg,净能分别为6.43和6.57 MJ/kg。 展开更多
关键词 肉鸡 净能 玉米 玉米DDGS
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柏子养心丸联合坦度螺酮治疗老年广泛性焦虑症的临床研究
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作者 张绪伟 王友培 +1 位作者 李芬林 张健 《现代药物与临床》 CAS 2019年第2期332-336,共5页
目的探讨柏子养心丸联合枸橼酸坦度螺酮片治疗老年广泛性焦虑症的临床疗效。方法选取2017年6月—2018年6月在青岛市城阳区人民医院治疗的老年广泛性焦虑症患者86例,根据用药的差别分为对照组(43例)和治疗组(43例)。对照组口服枸橼酸坦... 目的探讨柏子养心丸联合枸橼酸坦度螺酮片治疗老年广泛性焦虑症的临床疗效。方法选取2017年6月—2018年6月在青岛市城阳区人民医院治疗的老年广泛性焦虑症患者86例,根据用药的差别分为对照组(43例)和治疗组(43例)。对照组口服枸橼酸坦度螺酮片,10 mg/次,3次/d;治疗组在对照组基础上口服柏子养心丸,6 g/次,2次/d。两组患者均治疗4周。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状评分、HAMA、SAS和PSQI评分及免疫指标和神经递质水平。结果治疗后,对照组和治疗组临床总有效率分别为79.07%和95.35%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者临床症状积分均显著降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组HAMA、SAS和PSQI量表评分均显著降低(P<0.05),且治疗组HAMA、SAS和PSQI评分明显低于对照组(P<0.05)。治疗后,两组IgG、IgA、IgM水平均显著升高(P<0.05),且治疗组IgG、IgA、IgM水平明显高于对照组(P<0.05)。治疗后,两组肾上腺素(EPH)、5-羟色胺(5-HT)和去甲肾上腺素(NE)水平均显著降低(P<0.05),且治疗组神经递质水平明显低于对照组(P<0.05)。结论柏子养心丸联合盐酸曲唑酮片治疗老年广泛性焦虑症可有效改善患者临床症状,提高患者睡眠和生活质量,提高机体免疫能力。 展开更多
关键词 柏子养心丸 枸橼酸坦度螺酮片 广泛性焦虑症 临床症状评分 5-羟色胺 去甲肾上腺素
温肺除饮汤方药对痰湿蕴肺证慢性阻塞性肺疾病(COPD)急性加重期患者NE、EGFR表达的影响 预览
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作者 周满霞 郭永坚 +1 位作者 练培森 张功安 《现代诊断与治疗》 CAS 2019年第11期1798-1800,共3页
目的探讨温肺除饮汤药对痰湿蕴肺证COPD急性加重期患者NE(中性粒细胞弹性蛋白酶)、EGFR(表皮生长因子受体)表达的影响。方法选择67例本院接诊的痰湿蕴肺证COPD患者,按随机数字法分为西药组(行基础治疗+氨溴索治疗)33例和中药组(行基础治... 目的探讨温肺除饮汤药对痰湿蕴肺证COPD急性加重期患者NE(中性粒细胞弹性蛋白酶)、EGFR(表皮生长因子受体)表达的影响。方法选择67例本院接诊的痰湿蕴肺证COPD患者,按随机数字法分为西药组(行基础治疗+氨溴索治疗)33例和中药组(行基础治疗+温肺除饮汤药治疗)34例。分析两组用药疗效、用药前后NE、EGFR表达水平和中医症候积分情况。结果中药组治疗总有效率(94.12%)高于西药组(72.73%)(P<0.05);用药后两组患者NE和EGFR水平均低于用药前,中药组用药后NE和EGFR水平低于西药组(P<0.05);用药后两组咳嗽、喘息等中医症候积分均低于用药前,且用药后中药组症候积分低于西药组(P<0.05)。结论温肺除饮汤治疗痰湿蕴肺证COPD急性加重期能达到较好疗效,能有效降低NE和EGFR表达水平,改善气道粘液的高分泌状态和中医症候。 展开更多
关键词 痰湿蕴肺证 COPD急性加重期 温肺除饮汤 NE EGFR
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九味熄风颗粒联合可乐定透皮贴片治疗小儿抽动症的临床研究
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作者 张慧娟 江志拴 +4 位作者 李琳 陈超 周颖 贺雪 张璟 《现代药物与临床》 CAS 2019年第7期2077-2081,共5页
目的探讨九味熄风颗粒联合可乐定透皮贴片治疗小儿抽动症的临床疗效。方法选取2017年3月-2018年3月在濮阳市妇幼保健院治疗抽动症患儿82例,根据入院顺序分为对照组(41例)和治疗组(41例)。对照组给予可乐定透皮贴片,体质量≤40 kg者1.0 ... 目的探讨九味熄风颗粒联合可乐定透皮贴片治疗小儿抽动症的临床疗效。方法选取2017年3月-2018年3月在濮阳市妇幼保健院治疗抽动症患儿82例,根据入院顺序分为对照组(41例)和治疗组(41例)。对照组给予可乐定透皮贴片,体质量≤40 kg者1.0 mg/次,1次/周;40 kg<体质量≤60 kg者1.5 mg/次,体质量>60 kg者2.0 mg/次,1次/周。治疗组在对照组基础上口服九味熄风颗粒,4~6岁,1袋/次,2次/d;7~9岁,1.5袋/次,2次/d;10~14岁,2袋/次,2次/d。两组均治疗6周。观察两组患者临床疗效,同时比较治疗前后两组患者症状积分、血清谷氨酸(GLU)、门冬氨酸(ASP)、γ-氨基丁酸(GABA)水平及神经递质水平。结果治疗后,对照组和治疗组临床有效率分别为80.49%和97.56%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者眨眼次数、眨眼频率、眨眼强度积分和YGTSS评分均显著降低(P<0.05),且治疗组患者上述积分明显低于对照组患者(P<0.05)。治疗后,两组患者血清GLU、ASP水平均显著降低(P<0.05),GABA水平显著升高(P<0.05),且治疗组患者GLU、Asp、GABA水平明显好于对照组患者(P<0.05)。治疗后,两组患者血清多巴胺(DA)、5-羟色胺(5-HT)与去甲肾上腺素(NE)水平显著均降低(P<0.05),且治疗组患者DA、5-HT、NE水平明显低于对照组患者(P<0.05)。结论九味熄风颗粒联合可乐定透皮贴片治疗小儿抽动症可有效改善患儿临床症状,降低机体神经递质水平,具有一定的临床推广应用价值。 展开更多
关键词 九味熄风颗粒 可乐定透皮贴片 小儿抽动症 神经递质 Γ-氨基丁酸 去甲肾上腺素
布地奈德联合辛伐他汀对COPD大鼠肺组织NE及YKL-40表达的影响 预览
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作者 杨丽霞 贾钦尧 +1 位作者 蒋莉 董琼 《临床肺科杂志》 2018年第12期2151-2155,共5页
目的 观察布地奈德联合辛伐他汀对COPD(慢性阻塞性肺疾病,Chronic obstructive pulmonary disease)大鼠肺组织NE(中性粒细胞弹性蛋白酶, Neutrophil elastase)及YKL-40(软骨蛋白39,Cartilage protein 39)表达的影响。 方法 选... 目的 观察布地奈德联合辛伐他汀对COPD(慢性阻塞性肺疾病,Chronic obstructive pulmonary disease)大鼠肺组织NE(中性粒细胞弹性蛋白酶, Neutrophil elastase)及YKL-40(软骨蛋白39,Cartilage protein 39)表达的影响。 方法 选择200只SPF(无特定病原体级,specific pathogen free)级大鼠,按随机数字分为4组,即M组(模型组,model group)、BD组(布地奈德组,budesonide group)、SV组(辛伐他汀组,simvastatin group)、BD+SV组(布地奈德联合辛伐他汀组,budesonide combined simvastatin group),各50只。M组大鼠按照模型建立COPD小鼠的模型,其余三组分别进行不同的干预方案。12周后观察4组大鼠的体质量、血清炎性介质、肺组织的病理改变以及肺组织中的NE、YKL-40的表达水平。 结果 BD组、SV组以及BD+SV组的大鼠体质量存在均匀增加趋势, M组大鼠体质量增加幅度显著低于同时间段的BD组、SV组以及BD+SV组的大鼠,4组大鼠体质量在组间、时点间、组间-时点间的比较差异较大,差异有统计学意义( P〈 0.05);各组大鼠的血清炎症因子IL-6(白细胞介素6,Interleukin 6)、IL-8(白细胞介素8,Interleukin 8)、TNF-α(肿瘤坏死因子α, tumor necrosis factor-α)相比,差异有统计学意义( P〈 0.05),各组的LTB4(白三烯B4,Leukotriene B4)之间差异不大,无统计学意义( P〉 0.05);与M组相比,其余三组的病理半定量评分均显著下降,差异有统计学意义( P〈 0.05),BD组、SV组、BD+SV组之间进行两两比较,病理半定量评分差异不大,差异无统计学意义( P〉 0.05);其余三组与M组相比,NE显著减少,差异有统计学意义( P〈 0.05);M组的YKL-40显著高于其余三组,差异较大,有统计学意义( P〈 0.05)。 结论 布地奈德联合辛伐他汀能够有效地降低COPD大鼠的全身炎症、气道炎症反应,改善肺组织 展开更多
关键词 布地奈德 辛伐他汀 COPD大鼠 NE YKL-40
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加味逍遥丸治疗乳腺癌术后伴抑郁疗效及其对血浆5-HT、DA、NE的影响 被引量:2
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作者 胡鑫 李凤珍 +3 位作者 尚亚平 王宁 韩涛 李京 《长春中医药大学学报》 2018年第4期725-727,共3页
目的探究加味逍遥丸治疗乳腺癌术后伴有抑郁疗效及其对血浆5-HT、DA、NE的影响。方法选取我院收治的乳腺癌术后伴有抑郁患者80例,依据随机数字表法随机分为对照组和治疗组,各40例,对照组给予TCAS等抗抑郁药予以治疗,治疗组在对照组的基... 目的探究加味逍遥丸治疗乳腺癌术后伴有抑郁疗效及其对血浆5-HT、DA、NE的影响。方法选取我院收治的乳腺癌术后伴有抑郁患者80例,依据随机数字表法随机分为对照组和治疗组,各40例,对照组给予TCAS等抗抑郁药予以治疗,治疗组在对照组的基础上予以加味逍遥丸治疗,15 d为1个疗程,2组均连续治疗2个疗程。比较治疗前后2组患者临床疗效、血浆5-HT、DA、NE表达水平及抑郁症状积分改善情况。结果治疗后,治疗组总有效率为97.50%,优于对照组的80.00%,治疗组较对照组改善明显(P〈0.05);治疗后,2组血浆5-HT、DA、NE水平均上升,治疗组各指标水平上升程度显著优于对照组(P〈0.05);治疗后,2组患者抑郁症状积分均下降,与对照组相比,治疗组下降幅度更为显著(P〈0.05)。结论加味逍遥丸具有疏肝解郁、调和肝脾、调畅情志等诸多疗效,对于本病的治疗,可实现提高抑郁状态下血浆5-HT、DA及NE表达水平。 展开更多
关键词 加味逍遥丸 乳腺癌 抑郁症 5-HT DA NE
Petrogenesis and Geodynamic Implications of Late Jurassic Diorite Porphyry in the Neoproterozoic Ophiolitic Mélange of NE Jiangxi (South China) 预览
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作者 WANG Xinshui GAO Jun +2 位作者 LI Jilei JIANG Tuo XUE Shengchao 《地质学报:英文版》 SCIE CAS CSCD 2018年第3期1008-1023,共16页
Mesozoic magmatism is widespread in the eastern South China Block and has a close geneticrelationship with intensive polymetallic mineralization. However, proper tectonic driver remains elusiveto reconcile the broad i... Mesozoic magmatism is widespread in the eastern South China Block and has a close geneticrelationship with intensive polymetallic mineralization. However, proper tectonic driver remains elusiveto reconcile the broad intracontinental magmatic province. This study presents integrated zircon U-Pbdating, Hf isotopes and whole-rock geochemistry of the Xiwan dioritic porphyry in the NE Jiangxiophiolitic mé1ange. Zircon U-Pb dating by SIMS and LA-ICP-MS methods yielded an emplacement ageof-160 Ma for the Xiwan diorite, confirming its inclusion into the Mesozoic magmatic province in SEChina, instead of a component of the Neoproterozoic ophiolitic mélange genetically. The dioritic rockshave low SiO2 (58.08wt%-59.15wt%), and high Na20 (5.00wt%-5.21wt%) and MgO (4.60wt%-5.24wt%) contents with low TFeO/MgO ratios (1.02-1.09). They show an adakitic geochemical affinitybut exhibit relatively low Sr/Y ratios (24.8-31.1) and high Y contents (14.6-18.3 ppm) compared to theDexing adakitic porphyries. In addition, the Xiwan diorites have moderately evolved zircon Hf isotopiccompositions (εHf(t)=-6.1--O.1; TDM2=1597-1219 Ma). These elemental and isotopic signatures suggestthat the Xiwan diorite formed through partial melting of a remnant arc lower crust (i.e., earlyNeoproterozoic mafic arc-related rocks) in response to the underplating of coeval maflc magmas. Inconjunction with the temporal-spatial distribution and complex geochemical characteristics of theMesozoic magmatism, our case study attests to the feasibility of a flat-slab subduction model indeveloping the broad intracontinental magmatic province in SE China. The flat-slab delamination tendsto trigger an asthenospheric upwelling and thus results in extensive partial melting of the overlyinglithospheric mantle and lower crustal materials in an extensional setting during the Mesozoic. 展开更多
关键词 ADAKITE FLAT-SLAB subduction Mesozoic NE JIANGXI South China Block
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