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Liposarcoma of the Back: Case Report 预览
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作者 A. Ma?ga I. Diakité +15 位作者 A. Bah T. Bathio B. Diassana A. B. Diallo A. A. Traoré M. Diallo B. T. Dembélé Y. Sidibé O. H. Saadé M. Kanté M. Konaté S. Dembélé M. Samaké A. Togo A. Traoré G. Diallo 《外科学(英文)》 2019年第4期141-145,共5页
Liposarcoma is a particular form of soft tissue sarcoma. First described by Virchow in 1860, liposarcoma is a rare mesenchymal tumor [1]. It represents 14% to 18% of all malignant tumors of the soft tissues and consti... Liposarcoma is a particular form of soft tissue sarcoma. First described by Virchow in 1860, liposarcoma is a rare mesenchymal tumor [1]. It represents 14% to 18% of all malignant tumors of the soft tissues and constitutes the most frequent soft tissue sarcoma [2]. For the majority of authors, it affects adult after the fourth decade. Because of the unusual age, we report a case of largeliposarcoma of the dorsal surface of the trunk. The appearance of the operative part made us think of a possible malignancy. A 35-year-old man without a notable patient history was admitted for a mass of the back discovered three years before without any notion of trauma. The patient affirms the recent appearance of an induration motivating the consultation. There were no associated signs such rectorrhagia, hematemesis, emaciation, pain. The physical examination finds a patient in good general condition. Locally, there is a swelling of the right lateral part of the 1/3 middle part of the back. It is an oval swelling of 25 cm long axis. Any fat tumor having a size more than 5 cm must therefore receive special attention even before the fourth decade. 展开更多
关键词 LIPOSARCOMA Unusualage MALIGNANCY
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Study of Etiological Profile, Clinical Profile and Short Term Outcome of Patients Presenting with Pericardial Effusion in a Tertiary Care Center, Nepal 预览
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作者 Raja Ram Khanal Ratna Mani Gajurel +5 位作者 Ravi Sahi Hemant Shrestha Chandra Mani Poudel Surya Devkota Sanjeev Thapa Smriti Shakya 《心血管病(英文)》 2019年第12期879-890,共12页
Introduction: Pericardial effusion is one of the common cardiac problems in our?part of the world and adds burden to the health and economy of the country, as it is associated with high risk of morbidity and mortality... Introduction: Pericardial effusion is one of the common cardiac problems in our?part of the world and adds burden to the health and economy of the country, as it is associated with high risk of morbidity and mortality. Our objective of the study was to determine the etiological spectrum of pericardial effusion, their clinical presentations and complications and assessing the usefulness of echocardiographic features of effusion in helping to determine the etiology. Methods: A cross-sectional observational prospective study of 63 patients with diagnosis of pericardial effusion was enrolled in the study. Pericardial effusion was diagnosed by echocardiography and pericardiocentesis was done in the cardiac catheterization room. Patients were followed up 3 monthly for 1 year and reassessed clinically and by echocardiography. Results: Patients presenting with pericardial effusion belonged to the age group of 8 to 88 years. The most common etiology was tuberculosis (36.5%) followed by malignancy (19%) and idiopathic/Viral (12.6%). Among malignancies, carcinoma lung was the most common cause followed by lymphoma. Pericardiocentesis was done in 46 patients (73%) and the approach was subxiphoid. The procedure-related complications were in 4 patients (6.3%) and there was no death as a consequence of the procedure. The total mortality was 12 (19%) with in-hospital death of 6 patients (9.5%). Conclusions: The study showed tuberculosis as the most common cause of pericardial effusion in developing countries like Nepal and as a cause of cardiac tamponade in contrast to the studies from the developed world where malignancy remains the leading cause. 展开更多
关键词 MALIGNANCY PERICARDIAL EFFUSION PERICARDIOCENTESIS TUBERCULOSIS
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Assessment of Radiotherapy Treatment Field on Portal Film Using Image Processing 预览
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作者 Nouf Abuhadi Ali Bakry Abdoelrahman Hassan 《生物物理学期刊(英文)》 2019年第4期267-275,共9页
Many factors contribute to the accuracy of delivered dose to patients in external-beam radiotherapy (EBRT). Although some of these factors can be checked by implementing suitable quality control procedures, the main a... Many factors contribute to the accuracy of delivered dose to patients in external-beam radiotherapy (EBRT). Although some of these factors can be checked by implementing suitable quality control procedures, the main aim was to assess the radiotherapy treatment filed on portal film using image processing technique in order to increase the accuracy of treatment delivery to the tumor by measuring the actual F/S, dose uniformity and penumbra size using portal film. This research is conducted at radiation therapy department, Khartoum Oncology Center (RICK), Khartoum state, Sudan, from July-2014 up to December-2014. The field size of each type of radiotherapy Co60 is measured as (9.4 × 9.4) cm and (9.1 × 9.1) cm, for linear accelerator machines it was 10 × 10 cm exactly as the reference field size, and there is no area reduced in linacs. The penumbra size for the two types of Co60 machine was measured also and it was 1.2 cm and 1.0 cm, and penumbra size of the linear accelerator machines was found to be 4 mm. The area of the field that received radiation by 100% was measured and it was 94.1% and 91.1% in Co60 and 100% for linear accelerator machine and that means linacs deliver the 100% of the dose to the useful field size. The dose percentage in the field for Co60 was 98.0% and 94.1% and thus the dose in the border of field 83.1% and 89.0% and it’s different in linacs because the dose percentage in the field was 78.4% and 78.4% and there is no measurable dose outside its field. Penumbra Co60 machines are relatively large which increase radiation dose to normal tissue and reduce the TCP, so calculation and accuracy of such calculation are necessary to the patient in term of NTCP. 展开更多
关键词 Films Image Processing RADIOTHERAPY RICK MALIGNANCY IDL ONCOLOGY
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Incidence of Ostomies in Tertiary Care Teaching Institution 预览
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作者 D. Devi Keerthana A. Rekha 《临床医学病理报告(英文)》 2019年第7期181-188,共8页
A retrospective observational study was conducted at Saveetha medical college and hospital, over 2 years, from January 2017-January 2019. A total of 29 patients with ostomies were included in this study. Information r... A retrospective observational study was conducted at Saveetha medical college and hospital, over 2 years, from January 2017-January 2019. A total of 29 patients with ostomies were included in this study. Information regarding the types and indications of the ostomies were collected from the hospital records. The collected data were analyzed using Microsoft Excel, and represented by tables and charts. Majority of patients were the males and the predominant age group was 51 - 60 years old. The objective of the present study was to classify ostomies based on organs and to analyze the aetiology for creating those ostomies. 展开更多
关键词 Ostomies ILEOSTOMY JEJUNOSTOMY COLOSTOMY INDICATIONS MALIGNANCY
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Prevalence of Unsatisfactory Pap Smear and Associated Clinical History and Diagnosis in a Tertiary Teaching Hospital in Ghana 预览
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作者 Maxwell Hubert Antwi Seth Christopher Yaw Appiah 《生物医学工程(英文)》 2019年第6期311-321,共11页
Background: A major limitation of cervical cytology is the unsuitability of proportion of smears submitted for analysis and for cytological assessment (unsatisfactory). This study examines the prevalence of unsatisfac... Background: A major limitation of cervical cytology is the unsuitability of proportion of smears submitted for analysis and for cytological assessment (unsatisfactory). This study examines the prevalence of unsatisfactory Pap smear, clinical history and diagnosis in the Department of Pathology, Korle-Bu Teaching Hospital (KBTH), Ghana. Materials and Methods: A retrospective review of 15,290 cases spanning 12 years (2005-2016) was carried out at the cytology unit of the Pathology Department of the KBTH. Out of the 15,290 Pap smear records retrieved, 2347 reports were excluded leaving 12,943 for the study. All unsatisfactory smear cases were analyzed and categorized using the Bethesda 2001 System. Results are presented using descriptive statistics. Results: The overall prevalence of unsatisfactory Pap smear was 402 (3.1%). Routine screening smear accounted for 115 (0.9%);reports without clinical history and diagnosis gave 21 (0.2%) and cases with clinical history and diagnosis were 287 (2.2%). The common cause of unsatisfactory Pap smear was scanty cellularity 222 (1.72%). Patient’s history accounted for the least cause of unsatisfactory Pap smear 2 (0.02%). Conclusion: Pap smear results reported as unsatisfactory could harbor cancer malignancy. Samples should be taken by well-trained persons. 展开更多
关键词 PAP SMEAR Unsatisfactory BETHESDA System MALIGNANCY Ghana
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五聚素3在子宫内膜癌组织中的表达及与子宫内膜癌恶性程度和预后的关系 预览
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作者 杜巍 邵淑娟 王宏利 《中国肿瘤外科杂志》 CAS 2019年第4期264-268,共5页
目的探讨五聚素3(PTX3)在子宫内膜癌组织中的表达及其与子宫内膜癌恶性程度和预后的关系。方法将2015年1月至2016年12月中国石油集团公司中心医院收治的167例子宫内膜癌患者作为研究对象,收集患者子宫内膜癌组织(1.5cm×1.0cm×... 目的探讨五聚素3(PTX3)在子宫内膜癌组织中的表达及其与子宫内膜癌恶性程度和预后的关系。方法将2015年1月至2016年12月中国石油集团公司中心医院收治的167例子宫内膜癌患者作为研究对象,收集患者子宫内膜癌组织(1.5cm×1.0cm×1.0cm)作为检测样本,另取癌旁组织(距癌组织边缘≥5cm)作为对照组织,分别采用RT-PCR及westernblot检测子宫内膜癌组织中PTX3mRNA及蛋白的表达水平,并分析PTX3表达水平与子宫内膜癌恶性程度和预后的关系。结果子宫内膜癌组患者组织中PTX3mRNA表达水平(4.93±0.89)明显高于相应癌旁组织(0.96±0.31),差异具有统计学意义(P<0.05),且PTX3蛋白表达水平(1.98±0.54)也明显高于相应癌旁组织(0.43±0.26),差异也具有统计学意义(P<0.05)。PTX3表达水平与子宫内膜癌患者病理分期、分化程度、淋巴结转移、浸润肌层深度有关(P<0.05),而与年龄、病理类型无关(P>0.05)。PTX3mRNA高表达组(≥4.93)与低表达组(<4.93)的无进展生存期分别为10个月(95%CI为7.8~12.1个月)和19个月(95%CI为13.9~23.8个月),二者相比差异有统计学意义(P<0.05);总生存期分别为14个月(95%CI为10.3~17.0个月)和24个月(95%CI为17.6~29.2个月),二者相比差异也有统计学意义(P<0.05)。结论PTX3表达水平升高与子宫内膜癌的恶性程度有关,可能对子宫内膜癌的预后判断具有一定的指导价值。 展开更多
关键词 子宫内膜癌 五聚素3 恶性程度 预后
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Validation and head-to-head comparison of four models for predicting malignancy of intraductal papillary mucinous neoplasm of the pancreas:A study based on endoscopic ultrasound findings 预览
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作者 Jie Hua Bo Zhang +8 位作者 Xiu-Jiang Yang Yi-Yin Zhang Miao-Yan Wei Chen Liang Qing-Cai Meng Jiang Liu Xian-Jun Yu Jin Xu Si Shi 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第11期1043-1053,共11页
BACKGROUND Several models are currently available for predicting the malignancy of pancreatic intraductal papillary mucinous neoplasm(IPMN),namely,the Pancreatic Surgery Consortium(PSC),the Japan Pancreas Society(JPS)... BACKGROUND Several models are currently available for predicting the malignancy of pancreatic intraductal papillary mucinous neoplasm(IPMN),namely,the Pancreatic Surgery Consortium(PSC),the Japan Pancreas Society(JPS),the Johns Hopkins Hospital(JHH),and the Japan-Korea(JPN-KOR)models.However,a head-to-head comparison that shows which model is more accurate for this individualized prediction is lacking.AIM To perform a head-to-head comparison of the four models for predicting the malignancy of pancreatic IPMN.METHODS A total of 181 patients with IPMN who had undergone surgical resection were identified from a prospectively maintained database.The characteristics of IPMN in patients were recorded from endoscopic ultrasound imaging data and report archives.The performance of all four models was examined using Harrell’s concordance index(C-index),calibration plots,decision curve analyses,and diagnostic tests.RESULTS Of the 181 included patients,94 were categorized as having benign disease,and the remaining 87 were categorized as having malignant disease.The C-indexes were 0.842[95%confidence interval(CI):0.782-0.901],0.704(95%CI:0.626-0.782),0.754(95%CI:0.684-0.824),and 0.650(95%CI:0.483-0.817)for the PSC,JPS,JHH,and JPN-KOR models,respectively.Calibration plots showed that the PSC model had the least pronounced departure from ideal predictions.Of the remaining three models,the JPS and JHH models underestimated the probability of malignancy,while the JPN-KOR model overestimated the malignant potential of branch duct-IPMN.Decision curve analysis revealed that the PSC model resulted in a better clinical net benefit than the three other models.Diagnostic tests also showed a higher accuracy(0.801)for the PSC model.CONCLUSION The PSC model exhibited the best performance characteristics.Therefore,the PSC model should be considered the best tool for the individualized prediction of malignancy in patients with pancreatic IPMN. 展开更多
关键词 Intraductal papillary mucinous neoplasms Prediction model Endoscopic ultrasound Mural nodules MALIGNANCY
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妇科恶性肿瘤相关的下肢淋巴水肿的防治
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作者 李丹 楼寒梅 《中华整形外科杂志》 CAS CSCD 北大核心 2019年第7期710-713,共4页
下肢淋巴水肿是妇科恶性肿瘤淋巴结清扫术后或放疗后的主要并发症之一,主要是由于手术或放疗损伤了淋巴管,淋巴回流通路受阻,大量淋巴液进入组织间隙,从而导致下肢水肿,如治疗不及时,水肿进一步加重,将影响患者的生活质量.因此,肿瘤患... 下肢淋巴水肿是妇科恶性肿瘤淋巴结清扫术后或放疗后的主要并发症之一,主要是由于手术或放疗损伤了淋巴管,淋巴回流通路受阻,大量淋巴液进入组织间隙,从而导致下肢水肿,如治疗不及时,水肿进一步加重,将影响患者的生活质量.因此,肿瘤患者的早期评估尤为重要,改善治疗方式及早期预防有助于减少下肢淋巴水肿的发病率.该文对妇科恶性肿瘤相关的下肢淋巴水肿的诊断、治疗及预防现状进行综述. 展开更多
关键词 淋巴水肿 治疗 恶性肿瘤
PKD1、MAP2K4蛋白在子宫内膜癌中的表达及与病理学特征的相关性 预览
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作者 娄欢 武明莉 +1 位作者 刘芳 杨小风 《实验与检验医学》 CAS 2019年第3期352-355,共4页
目的探讨蛋白激酶D1(PKD1)、丝裂原活化蛋白激酶4(MAP2K4)在子宫内膜癌组织中的表达及与疾病恶性程度的关系。方法选取病理科于2015年3月至2017年1月收集的80例子宫内膜癌组织,符合要求的40例子宫内膜增生患者的子宫内膜组织(对照组),... 目的探讨蛋白激酶D1(PKD1)、丝裂原活化蛋白激酶4(MAP2K4)在子宫内膜癌组织中的表达及与疾病恶性程度的关系。方法选取病理科于2015年3月至2017年1月收集的80例子宫内膜癌组织,符合要求的40例子宫内膜增生患者的子宫内膜组织(对照组),采用免疫组化染色检测两组标本中PKD1蛋白、MAP2K4蛋白的表达,并分析PKD1蛋白、MAP2K4蛋白与国际妇产联盟分期(FIGO)、分化程度、肌层浸润深度、淋巴结转移、病灶大小的关系。结果子宫内膜癌组织中的PKD1蛋白、MAP2K4蛋白阳性表达率分别为71.25%、50.00%,对照组子宫内膜组织中的PKD1蛋白、MAP2K4蛋白阳性表达率分别为12.50%、82.50%,两组比较差异具有统计学意义(P<0.05);低分化、FIGO分期(Ⅲ期+Ⅳ期)、发生淋巴结转移的子宫内膜癌组织中的PKD1蛋白阳性表达率显著的高于高中分化、FIGO分期(Ⅰ期+Ⅱ期)、未发生淋巴结转移的子宫内膜癌组织(P<0.05);低分化、FIGO分期(Ⅲ期+Ⅳ期)、发生淋巴结转移、肌层浸润深度≥1/2的子宫内膜癌组织中的MAP2K4蛋白阳性表达率显著的低于高中分化、FIGO分期(Ⅰ期+Ⅱ期)、未发生淋巴结转移、肌层浸润深度<1/2的子宫内膜癌组织(P<0.05)。结论子宫内膜癌组织中PKD1的表达分别上调、MAP2K4蛋白的表达下调,相关水平与肿瘤的病理学特征关系密切。 展开更多
关键词 蛋白激酶D1 丝裂原活化蛋白激酶4 子宫内膜癌 恶性程度
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人工智能在恶性肿瘤诊治中的应用
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作者 袁紫旭 徐挺洋 +2 位作者 姚建华 蔡建 王磊 《中华实验外科杂志》 CAS CSCD 北大核心 2019年第2期203-207,共5页
人工智能(AI)是研发用于模拟人类大脑学习并且延伸人类能力的新型智能技术科学。近年来,医疗大数据的深度挖掘归功于AI的突破发展,也推动了AI+医疗创新模式的发展。我们将阐述AI在医学领域的应用及其原理,特别是在肿瘤诊治方面的优势,包... 人工智能(AI)是研发用于模拟人类大脑学习并且延伸人类能力的新型智能技术科学。近年来,医疗大数据的深度挖掘归功于AI的突破发展,也推动了AI+医疗创新模式的发展。我们将阐述AI在医学领域的应用及其原理,特别是在肿瘤诊治方面的优势,包括AI擅长的医学图像(影像、病理)处理,为AI奠定基础的影像组学的发展,AI更新换代后深度学习算法的优势,AI在诊断、特征提取、监测、疗效随访中的应用等。随着AI在不同疾病中应用经验的积累,深度学习算法可以利用越来越多的医疗大数据进行训练和验证模型,我们期待AI的灵敏性和准确性会有更大的提升,甚至可能超越影像专家及病理专家对肿瘤的诊治水平。 展开更多
关键词 人工智能 恶性肿瘤 深度学习算法 诊断
肿瘤患者念珠菌血症的危险因素和病原体分析 预览
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作者 孙明月 肖伟强 +2 位作者 常彦敏 屈元晔 许青霞 《中国肿瘤临床》 CAS CSCD 北大核心 2019年第10期513-517,共5页
目的:本研究旨在确定念珠菌血症的危险因素,评估肿瘤患者中近平滑假丝酵母菌和其他念珠菌之间可能存在的临床显著性差异。并对白假丝酵母菌血症和近平滑假丝酵母菌血症的临床特点及危险因素进行统计学分析,旨在通过该类分析,及时开展干... 目的:本研究旨在确定念珠菌血症的危险因素,评估肿瘤患者中近平滑假丝酵母菌和其他念珠菌之间可能存在的临床显著性差异。并对白假丝酵母菌血症和近平滑假丝酵母菌血症的临床特点及危险因素进行统计学分析,旨在通过该类分析,及时开展干预,尽量避免易感因素,进而改善真菌血症患者预后。方法:回顾性分析郑州大学附属肿瘤医院2012年3月至2018年2月323例念珠菌血症患者的资料。分析患者发生念珠菌血症的危险因素,同时对比分析近平滑假丝酵母菌和非近平滑假丝酵母菌、白假丝酵母菌和非白假丝酵母菌念珠菌血症的临床差异。通过微量肉汤稀释法对念珠菌常见抗真菌药物进行药敏试验和分析。结果:念珠菌血症分离病原体中,最常见的为近平滑假丝酵母菌37.15%(120/323),而白假丝酵母菌占34.37%。多变量回归分析结果表明,下述因素与近平滑假丝酵母菌念珠菌血症的发生相关,即肠外营养(P<0.001)、粒缺(P<0.001)、化疗(P<0.001)和抗真菌药物的使用(P<0.001),同时肠外营养为近平滑假丝酵母菌念珠菌血症发生的独立危险因素(OR=0.183,95%CI:0.098~0.340;P<0.001)。结论:近平滑假丝酵母菌超越白假丝酵母菌为患者念珠菌血症主要病原体。通过评估患者念珠菌血症发生的可能危险因素,以期加强和制定感染控制策略,从而预防念珠菌血症的传播。 展开更多
关键词 念珠菌血症 肿瘤 白假丝酵母菌 近平滑假丝酵母菌
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胃肠道微生物在肿瘤发生中的作用 预览
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作者 陆海洋 赵维莅 《上海交通大学学报:医学版》 CAS CSCD 北大核心 2019年第9期1083-1088,共6页
胃肠道微生物对人体的生理功能具有重要影响。近年,人们发现微生物在肿瘤发生发展中亦起到关键作用。异常细菌定植和菌群比例失调不仅能诱发胃肠道局部上皮组织的癌变,还可能影响黏膜下淋巴组织甚至远端器官的癌变。一些微生物可通过产... 胃肠道微生物对人体的生理功能具有重要影响。近年,人们发现微生物在肿瘤发生发展中亦起到关键作用。异常细菌定植和菌群比例失调不仅能诱发胃肠道局部上皮组织的癌变,还可能影响黏膜下淋巴组织甚至远端器官的癌变。一些微生物可通过产生遗传毒素或活性氧损伤DNA和干扰细胞DNA修复机制,引起细胞遗传学不稳定而诱导细胞转化。此外,胃肠道微生物还影响宿主免疫系统功能,构成免疫抑制的微环境,或者诱导慢性炎症反应促进肿瘤发生。胃肠道微生物通过多种机制共同促进肿瘤的发生发展,显示出其与肿瘤的密切关系。 展开更多
关键词 胃肠道微生物 恶性肿瘤 遗传学不稳定性 氧化应激 炎症反应
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关于嵌合抗原受体T细胞疗法毒性事件的分级与管理
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作者 张红曼 张健 《中国肿瘤》 CAS CSCD 北大核心 2019年第4期301-307,共7页
嵌合抗原受体T细胞(chimeric antigen receptor T cells,CAR-T)治疗是近年来迅速发展的肿瘤过继免疫治疗方法,可用于治疗多种恶性肿瘤,此外还有TCR-gene治疗、CAR-NK细胞治疗以及TCR-T细胞免疫治疗等方法。但是CAR-T细胞治疗有三大独特... 嵌合抗原受体T细胞(chimeric antigen receptor T cells,CAR-T)治疗是近年来迅速发展的肿瘤过继免疫治疗方法,可用于治疗多种恶性肿瘤,此外还有TCR-gene治疗、CAR-NK细胞治疗以及TCR-T细胞免疫治疗等方法。但是CAR-T细胞治疗有三大独特的毒性不良事件,即细胞因子释放综合征、CAR-T细胞治疗相关性脑病综合征、暴发性溶血性淋巴细胞增多症/巨噬细胞活化综合症。此三大毒性事件绝大部分可以控制,但有些也是致命的,所以对毒性事件的正确认知及处理非常重要。全文对CAR-T细胞免疫治疗引发的毒性事件的分级和管理行进一步综述。 展开更多
关键词 嵌合抗原受体T细胞治疗 恶性肿瘤 细胞因子释放综合征 脑病综合征 暴发性溶血性淋巴细胞增多症
结核与肿瘤患者胸腔积液中TNF-α,IFN-γ,IL-2,IL-4的水平及临床意义 预览
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作者 武江海 舒敬奎 +3 位作者 张剑青 冯家钢 贾曼 刘凌 《昆明医科大学学报》 CAS 2019年第12期103-107,共5页
目的探讨肿瘤坏死因子(tumor necrosis factor,TNF)-α,γ干扰素(interferon-γ,IFN-γ),白细胞介素(interleukin,IL)-2,IL-4在结核性和肿瘤性胸腔积液中的水平及临床意义。方法收集2016年4月至2018年6月在昆明医科大学第一附属医院呼... 目的探讨肿瘤坏死因子(tumor necrosis factor,TNF)-α,γ干扰素(interferon-γ,IFN-γ),白细胞介素(interleukin,IL)-2,IL-4在结核性和肿瘤性胸腔积液中的水平及临床意义。方法收集2016年4月至2018年6月在昆明医科大学第一附属医院呼吸内科住院的确诊为结核性或肿瘤性胸腔积液患者的胸腔积液和血清标本,其中结核性30例,肿瘤性32例。采用酶联免疫吸附法(ELISA)测定胸腔积液和血清中TNF-α,IFN-γ,IL-2,IL-4浓度,并分析结果及其临床意义。结果 (1)结核组胸腔积液中TNF-α,IFN-γ,IL-2的浓度高于其血清浓度(P <0.05);肿瘤组胸腔积液中IL-2的浓度高于其血清浓度(P <0.05);(2)结核组胸腔积液中TNF-α,IFN-γ,IL-2及血清中IFN-γ浓度高于肿瘤组(P <0.01);(3) IL-4的胸腔积液和血清浓度,及血清中TNF-α,IL-2浓度在结核和肿瘤组间差异无统计学意义(P> 0.05)。(4) ROC曲线结果显示,胸腔积液中TNF-α,IFN-γ,IL-2及血清中IFN-γ的浓度均可作为鉴别结核和肿瘤性胸腔积液的指标。结论结核性胸腔积液由TH1细胞介导的局限于胸膜腔的免疫反应占主导;结核性胸腔积液患者胸腔积液中TNF-α,IFN-γ,IL-2的浓度及血清中IFN-γ的浓度升高,可有效鉴别结核和肿瘤性胸腔积液。 展开更多
关键词 肿瘤坏死因子α 白细胞介素类 干扰素Γ 胸腔积液 结核 恶性肿瘤
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Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue 预览
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作者 Arthur Laquière Arnaud Lagarde +13 位作者 Bertrand Napoléon Raphael Bourdariat Alexandre Atkinson Gianfranco Donatelli Bernard Pol Laurence Lecomte Laurence Curel Romina Urena-Campos Thierry Helbert Vincent Valantin Francois Mithieux Jean Pascal Buono Philippe Grandval Sylviane Olschwang 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第36期5530-5542,共13页
BACKGROUND DNA mutational analysis of pancreatic cystic fluid (CF) is a useful adjunct to the evaluation of pancreatic cysts. KRAS/GNAS or RAF/PTPRD/CTNNB1/RNF43 mutations are highly specific to precancerous or advanc... BACKGROUND DNA mutational analysis of pancreatic cystic fluid (CF) is a useful adjunct to the evaluation of pancreatic cysts. KRAS/GNAS or RAF/PTPRD/CTNNB1/RNF43 mutations are highly specific to precancerous or advanced neoplasia. Several studies recently demonstrated the ability of next-generation sequencing (NGS)analysis to detect DNA mutations in pancreatic CF, but few studies have performed a systematic comparative analysis between pancreatic CF and neoplastic surgical tissue (NT). The value of CF-NGS analysis indicators for determining surgical resection necessitates evaluation. AIM To confirm whether CF genomic profiles are a reliable malignancy predictor by comparing NGS mutational analyses of CF and NT. METHODS Patients requiring surgery for high-risk pancreatic cysts were included in a multicenter prospective pilot study. DNA from CF (collected by endoscopic ultrasound-guided fine needle aspiration (known as EUS-FNA)) and NT (collected by surgery) were analyzed by NGS. The primary objective was to compare the mutation profiles of paired DNA samples. The secondary objective was to correlate the presence of specific mutations (KRAS/GNAS, RAF/ PTPRD/CTNNB1/RNF43/POLD1/TP53) with a final cancer diagnosis. Sensitivity and specificity were also evaluated. RESULTS Between December 2016 and October 2017, 20 patients were included in this pilot study. Surgery was delayed for 3 patients. Concordant CF-NT genotypes were found in 15/17 paired DNA, with a higher proportion of mutated alleles in CF than in NT. NGS was possible for all pancreatic CF collected by EUS-FNA. In 2 cases, the presence of a KRAS/GNAS mutation was discordant between CF and NT. No mutations were found in 3 patients with NT or pancreatic cysts with high-grade dysplasia. The sensitivity and specificity of KRAS/GNAS mutations in CF to predict an appropriate indication for surgical resection were 0.78 and 0.62, respectively. The sensitivity and specificity of RAF/PTPRD/CTNNB1 /RNF43/POLD1/TP53 mutations in CF were 0.55 and 1.0, respectively. CONCLU 展开更多
关键词 PANCREATIC cancer PANCREATIC CYSTIC neoplasms PANCREATIC adenocarcinoma MALIGNANCY prediction NEOPLASTIC surgical TISSUE PANCREATIC CYSTIC fluid Molecular analysis Next-generation sequencing DNA mutations
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丙酮酸脱氢酶激酶在恶性肿瘤中的研究进展
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作者 王秋月 贾方(综述) 王菊勇(审校) 《肿瘤预防与治疗》 2019年第10期945-950,共6页
正常细胞能量代谢以线粒体的氧化磷酸化为主,而癌细胞则以有氧糖酵解为主。这种代谢特征的偏移与丙酮酸脱氢酶激酶及其相关蛋白密切相关。本文通过介绍该激酶功能及相关蛋白、抑制剂的研究情况等,以阐述其在恶性肿瘤发生发展等方面的研... 正常细胞能量代谢以线粒体的氧化磷酸化为主,而癌细胞则以有氧糖酵解为主。这种代谢特征的偏移与丙酮酸脱氢酶激酶及其相关蛋白密切相关。本文通过介绍该激酶功能及相关蛋白、抑制剂的研究情况等,以阐述其在恶性肿瘤发生发展等方面的研究进展,进一步深入了解其在临床中的应用价值。 展开更多
关键词 有氧糖酵解 丙酮酸脱氢酶激酶 恶性肿瘤
PHC患者血清mir-355的表达水平变化及与肿瘤病理学特征的相关性 预览
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作者 王晓 马慧 张卫卫 《实验与检验医学》 CAS 2019年第5期828-831,共4页
目的探讨原发性肝癌(PHC)患者血清微小RNA-355(mir-355)的表达变化及与肿瘤肿瘤病理学特征的相关性。方法选取我院2015年1月至2016年12月经病理学明确诊断的90例PHC患者(PHC组)、慢性乙肝后肝硬化患者90例(对照组)、90例健康体检志愿者... 目的探讨原发性肝癌(PHC)患者血清微小RNA-355(mir-355)的表达变化及与肿瘤肿瘤病理学特征的相关性。方法选取我院2015年1月至2016年12月经病理学明确诊断的90例PHC患者(PHC组)、慢性乙肝后肝硬化患者90例(对照组)、90例健康体检志愿者(健康组),采用实时荧光定量PCR技术检测三组的血清mir-355水平,并分析不同甲胎蛋白(AFP)水平、病灶数目、病灶直径、是否发生脉管侵犯、不同分化程度、不同TNM分期患者的血清mir-355水平差异。结果PHC组、对照组的血清中mir-355水平显著低于健康组(P<0.05),PHC组的血清中mir-355水平显著低于对照组(P<0.05);病灶多发、病灶直径≥5cm、发生脉管侵犯、低分化、TNM分期(Ⅲ期+Ⅳ期)的PHC患者血清mir-355水平低于病灶单发、病灶直径<5cm、未发生脉管侵犯、高中分化、TNM分期(Ⅰ期+Ⅱ期)的PHC患者(P<0.05);不同AFP水平PHC患者的血清mir-355水平差异有统计学意义(P>0.05)。结论PHC患者血清mir-355的表达水平下调,并且与PHC的病灶数量、大小、是否发生脉管侵犯及分化、分期具有一定的相关性。 展开更多
关键词 原发性肝癌 微小RNA-355 恶性程度
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Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity
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作者 Juanjuan Feng Mingjin Rao +5 位作者 Man Wang Lin Liang Zhi Chen Xiufeng Pang Weiqiang Lu Zhenliang Sun 《中国科学:生命科学英文版》 SCIE CAS CSCD 2019年第10期1409-1412,共4页
Dear Editor,Pancreatic cancer (PCa) is a high-grade gastrointestinal malignancy more commonly occurring in elderly populations with lower than 5% overall 5-year survival rate (Hidalgo, 2010). PCa responds poorly to mo... Dear Editor,Pancreatic cancer (PCa) is a high-grade gastrointestinal malignancy more commonly occurring in elderly populations with lower than 5% overall 5-year survival rate (Hidalgo, 2010). PCa responds poorly to most chemotherapeutic agents, and therefore it is imperative to develop novel therapeutic agents that have anti-cancer activities against PCa. 展开更多
关键词 MALIGNANCY survival rate IMPERATIVE
巨大纵隔肿瘤31例治疗体会
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作者 房渝 吴庆琛 秦治明 《临床外科杂志》 2019年第2期146-148,共3页
目的总结巨大纵隔肿瘤的治疗经验。方法巨大纵隔肿瘤病人31例。根据肿瘤的位置、生长方向和与周围组织的关系,采用不同的手术入路和方式:3例T形切口入路手术,5例Hemi-clamshell切口手术,23例后外侧切口手术。记录围术期相关指标和手术... 目的总结巨大纵隔肿瘤的治疗经验。方法巨大纵隔肿瘤病人31例。根据肿瘤的位置、生长方向和与周围组织的关系,采用不同的手术入路和方式:3例T形切口入路手术,5例Hemi-clamshell切口手术,23例后外侧切口手术。记录围术期相关指标和手术要点。结果良性肿瘤病人17例,恶性肿瘤病人14例。恶性肿瘤病人的平均年龄低于良性肿瘤,平均体积大于良性肿瘤,手术时间、术后带管时间和术后住院时间均长于良性肿瘤,术中出血量大于良性肿瘤,差异均有统计学意义(P <0. 05)。恶性肿瘤需行扩大切除。对于上纵隔巨大恶性肿瘤,推荐采取肿块分块切除的策略。14例恶性肿瘤病人联合手术和辅助化疗,显示了较好的预后。结论手术是巨大纵隔肿瘤首选的治疗方式。恶性肿瘤手术风险更大,充分的术前评估,合理的手术方式,均可获得较好的预后。手术入路的选择和切除技巧是手术成功的关键。 展开更多
关键词 巨大纵隔肿瘤 手术 预后 恶性
恶性肿瘤患者免疫功能与抗核抗体的关系研究 预览
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作者 李亚波 林云 +1 位作者 邹映东 刘骥 《检验医学与临床》 CAS 2019年第1期48-50,共3页
目的探讨恶性肿瘤患者免疫功能与抗核抗体的关系。方法采集2010―2016年云南省中医医院190例恶性肿瘤患者作为恶性肿瘤组,选择同期40例体检健康者作为对照组。收集2组研究对象的血清抗核抗体(ANA)水平;检测恶性肿瘤组患者外周血淋巴细... 目的探讨恶性肿瘤患者免疫功能与抗核抗体的关系。方法采集2010―2016年云南省中医医院190例恶性肿瘤患者作为恶性肿瘤组,选择同期40例体检健康者作为对照组。收集2组研究对象的血清抗核抗体(ANA)水平;检测恶性肿瘤组患者外周血淋巴细胞亚群水平,并按ANA水平分为ANA阳性组和阴性组,比较2组患者淋巴细胞亚群水平。结果ANA滴度≥1∶100作为阳性判断标准时,190例恶性肿瘤组患者ANA阳性率为34.2%,ANA滴度>1∶320时,阳性率为24.2%。对照组ANA阳性率为5.0%。2种情况下,2组研究对象的ANA阳性率比较,差异均有统计学意义(P<0.05)。恶性肿瘤组患者ANA阴性组CD4^+/CD8^+为1.79(1.16,2.11),阳性组CD4^+/CD8^+为1.25(1.02,1.56),差异有统计学意义(P<0.05)。结论恶性肿瘤患者体内存在以ANA升高为表现的自身免疫现象,ANA阳性患者免疫功能处于抑制状态,自身免疫反应导致阳性组和阴性组细胞免疫功能的差异。 展开更多
关键词 恶性肿瘤 自身免疫性疾病 抗核抗体 淋巴细胞亚群
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