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Neuroprotective effects of minocycline on focal cerebral ischemia injury:a systematic review 预览
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作者 Yazdan Naderi Yunes Panahi +1 位作者 George E. Barreto Amirhosein Sahebkar 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期773-782,共10页
To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of... To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of the study.Studies were included if focal cerebral ischemia model was performed in mammals and including a control group that has been compared with a minocycline group.Written in languages other than English;duplicate data;in vitro studies and combination of minocycline with other neuroprotective agents were excluded.Neurological function of patients was assessed by National Institute of Health Stroke Scale,modified Rankin Scale,and modified Barthel Index.Neuroprotective effects were assessed by detecting the expression of inflammatory cytokines.We examined 35 papers concerning the protective effects of minocycline in focal cerebral ischemia in animal models and 6 clinical trials which had evaluated the neuroprotective effects of minocycline in ischemic stroke.These studies revealed that minocycline increases the viability of neurons and decreases the infarct volume following cerebral ischemia.The mechanisms that were reported in these studies included anti-inflammatory,antioxidant,as well as anti-apoptotic effects.Minocycline also increases the neuronal regeneration following cerebral ischemia.Minocycline has considerable neuroprotective effects against cerebral ischemia-induced neuronal damages.However,larger clinical trials may be required before using minocycline as a neuroprotective drug in ischemic stroke. 展开更多
关键词 ISCHEMIC STROKE MINOCYCLINE NEURONAL REGENERATION NEUROPROTECTION STROKE
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Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction 预览
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作者 Dao-Xia Guo Zheng-Bao Zhu +12 位作者 Chong-Ke Zhong Xiao-Qing Bu Li-Hua Chen Tan Xu Li-Bing Guo Jin-Tao Zhang Dong Li Jian-Hui Zhang Zhong Ju Chung-Shiuan Chen Jing Chen Yong-Hong Zhang Jiang He 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期922-928,共7页
Stroke is the leading cause of death and long-term disability worldwide,and cognitive impairment and dementia are major complications of ischemic stroke.Cystatin C (CysC) has been found to be a neuroprotective factor ... Stroke is the leading cause of death and long-term disability worldwide,and cognitive impairment and dementia are major complications of ischemic stroke.Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies.However,the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different results.This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months.Data from 638 patients were obtained from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS).Cognitive dysfunction was assessed using the Mini-Mental State Examination (MMSE) at 3 months after stroke.According to the MMSE score,308 patients (52.9%) had post-stroke cognitive dysfunction.After adjusting for potential confounding factors,the odds ratio (95% CI) of post-stroke cognitive dysfunction for the highest quartile of serum CysC levels was 0.54 (0.30–0.98),compared with the lowest quartile.The correlation between serum CysC and cognitive dysfunction was modified by renal function status.We observed a negative linear dose-response correlation between CysC and cognitive dysfunction in patients with normal renal function (Plinearity = 0.044),but not in those with abnormal renal function.Elevated serum CysC levels were correlated with a low risk of 3-month cognitive dysfunction in patients with acute ischemic stroke,especially in those with normal renal function.The current results suggest that CysC is a protective factor for post-stroke cognitive dysfunction,and could be used to treat post-stroke cognitive dysfunction.The CATIS study was approved by the Institutional Review Boards at Soochow University from China (approval No.2012-02) on December 30,2012,and was registered at ClinicalTrials.gov (identifier No.NCT01840072) on April 25,2013. 展开更多
关键词 abnormal RENAL FUNCTION cognitive dysfunction CYSTATIN C ischemic stroke Mini-Mental State Examination neural regeneration NEUROPROTECTIVE effect normal RENAL FUNCTION
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δ-Opioid receptor as a potential therapeutic target for ischemic stroke 预览
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作者 Kalpana Subedi Hongmin Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期20-24,共5页
Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels.Despite having advancement in the... Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels.Despite having advancement in the use of thrombolytic and clot removal medicine,significant numbers of stroke patients are still left out without option for treatment.In this review,we summarize recent research work on the activation ofδ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury.Moreover,as activation ofδ-opioid receptor by a non-peptidicδ-opioid receptor agonist also modulates the expression,maturation and processing of amyloid precursor protein andβ-secretase activity,the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed. 展开更多
关键词 AGONIST AKT AMYLOID precursor protein BDNF ischemic stroke NEUROPROTECTION δ-opioid receptor p38 MAPK PI3K TRKB
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Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke 预览
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作者 Bei Zhang Kathryn ESaatman Lei Chen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期416-424,共9页
Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmace... Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmaceuticals for stroke treatment.Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke,and highlight potential mechanisms underlying their therapeutic effects.It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways,thereby attenuating multiple aspects of ischemic pathology.We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke. 展开更多
关键词 cell death HERBAL compound immune response ISCHEMIC stroke therapy NEUROPLASTICITY NEUROPROTECTION oxidative damage traditional Chinese medicine
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Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage 预览
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作者 Rais Reskiawan Abdulkadir Mansour Alwjwaj +2 位作者 Othman Ahmad Othman Kamini Rakkar Ulvi Bayraktutan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1071-1078,共8页
Breakdown of blood-brain barrier,formed mainly by brain microvascular endothelial cells(BMECs),represents the major cause of mortality during early phases of ischemic strokes.Hence,discovery of novel agents that can e... Breakdown of blood-brain barrier,formed mainly by brain microvascular endothelial cells(BMECs),represents the major cause of mortality during early phases of ischemic strokes.Hence,discovery of novel agents that can effectively replace dead or dying endothelial cells to restore blood-brain barrier integrity is of paramount importance in stroke medicine.Although endothelial progenitor cells(EPCs)represent one such agents,their rarity in peripheral blood severely limits their adequate isolation and therapeutic use for acute ischemic stroke which necessitate their ex vivo expansion and generate early EPCs and outgrowth endothelial cells(OECs)as a result.Functional analyses of these cells,in the present study,demonstrated that only OECs endocytosed DiI-labelled acetylated low-density lipoprotein and formed tubules on matrigel,prominent endothelial cell and angiogenesis markers,respectively.Further analyses by flow cytometry demonstrated that OECs expressed specific markers for sternness(CD34),immaturity(CD133)and endothelial cells(CD31)but not for hematopoietic cells(CD45).Like BMECs,OECs established an equally tight in vitro model of human BBB with astrocytes and pericytes,suggesting their capacity to form tight junctions.Ischemic injury mimicked by concurrent deprivation of oxygen and glucose(4 hours)or deprivation of oxygen and glucose followed by reperfusion(20 hours)affected both barrier integrity and function in a similar fashion as evidenced by decreases in transendothelial electrical resistance and increases in paracellular flux,respectively.Wound scratch assays comparing the vasculoreparative capacity of cells revealed that,compared to BMECs,OECs possessed a greater proliferative and directional migratory capacity.In a triple culture model of BBB established with astrocytes,pericytes and BMEC,exogenous addition of OECs effectively repaired the damage induced on endothelial layer in serum-free conditions.Taken together,these data demonstrate that OECs may effectively home to the site of vascular injury and re 展开更多
关键词 cell-based therapy endothelial progenitor cells ENDOTHELIUM ischemic stroke NEURODEGENERATION novel therapeutics outgrowth endothelial cells regenerative medicine stem cells translational medicine
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急性缺血性脑卒中及短暂性脑缺血发作患者口服二级预防药物1年复合依从性影响因素分析 预览
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作者 李岩 佟旭 +3 位作者 吴雅坤 郭红梅 裴洪菲 曹亦宾 《山东医药》 CAS 2019年第24期18-22,共5页
目的 观察急性缺血性脑卒中(AIS)及短暂性脑缺血发作(TIA)患者二级预防药物1年复合依从性的影响因素。方法 收集2926例AIS及TIA患者的基线资料及3个月、6个月、1年随访时服药情况。基线资料包括:人口学信息(年龄、性别、民族、医保类型... 目的 观察急性缺血性脑卒中(AIS)及短暂性脑缺血发作(TIA)患者二级预防药物1年复合依从性的影响因素。方法 收集2926例AIS及TIA患者的基线资料及3个月、6个月、1年随访时服药情况。基线资料包括:人口学信息(年龄、性别、民族、医保类型、文化程度、家庭人均月收入、BMI指数)、既往史(吸烟史、饮酒史、高血压史、糖尿病史、脂代谢紊乱史、房颤史、TIA史、AIS史、心肌梗死史,既往服用抗栓药物史、降压药物史、降脂药物史、降糖药物史)、病情概况[发病前改良Rankin量表(mRS)评分,入院时美国国立卫生研究院卒中量表(NIHSS)评分、是否静脉溶栓、住院费用、出院时NIHSS评分、出院时mRS评分、脑卒中类型(AIS、TIA)]、出院带药种类数(仅限于抗栓药、降压药、降脂药、降糖药)。以患者药物复合依从率≥75%为界,将研究对象分为1年复合依从性好组(1257例,占43.0%)、1年复合依从性差组(1669例,占57.0%),比较两组患者的基线资料。将两组基线资料比较中P<0.2的自变量纳入Logistic回归模型,采用向后逐步剔除LR法进行多因素分析。结果 年龄、既往高血压史、既往脂代谢紊乱史、既往服用降压药物史、既往服用降糖药物史、住院费用、脑卒中类型、出院带药种类数等是AIS及TIA患者二级预防药物1年复合依从性的独立影响因素(P均<0.05)。结论 AIS及TIA患者的年龄、既往高血压史、既往脂代谢紊乱史、既往服用降压药物史、既往服用降糖药物史、住院费用、脑卒中类型、出院带药种类数与二级预防药物1年复合依从性有关。 展开更多
关键词 脑卒中 缺血性脑卒中 急性缺血性脑卒中 短暂性脑缺血发作 脑卒中二级预防药物 药物依从性
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Extracranial Carotid Atherosclerosis and Acute Ischemic Stroke in a Tertiary Hospital in Burkina Faso 预览
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作者 Alfred Anselme Dabilgou Alassane Dravé +3 位作者 Julie Marie Adeline Kyelem Hassan Koanda Christian Napon Jean Kaboré 《神经科学国际期刊(英文)》 2019年第2期39-51,共13页
Objective: To determine the prevalence and risk factors of carotid atherosclerosis among ischemic stroke patients in a tertiary hospital in Burkina Faso. Methodology: This was a descriptive and analytical retrospectiv... Objective: To determine the prevalence and risk factors of carotid atherosclerosis among ischemic stroke patients in a tertiary hospital in Burkina Faso. Methodology: This was a descriptive and analytical retrospective study of patients admitted at neurology department of Yalgado Ouedraogo University Teaching Hospital with ischemic stroke and cerebral large vessel atherosclerosis in the period from January 1, 2012 to December 31, 2016. Results: The prevalence of extracranial carotid atherosclerosis was 23.9%. The mean age of patients was 63.5 years (Range 31 - 90 years). The study population included 65% of men and 35% of women. Hypertension was the most common vascular risk factor (75.6%). Stroke was mostly located in the anterior circulation in 23.9%. Low HDL-C was present in 52% of patients. The majority of plaque was homogeneous (85.2%). Plaque were located in carotid bulbar artery (38.5%) followed by common carotid artery (28.2%) and extracranial internal carotid artery (18.6%). According to cerebral lesion, plaque was bilateral in 45.5%, ipsilateral in 42.3% and contralateral in 12.1% of cases. Tight stenosis was found in 30.1% of patients. There was a significant link between male gender and tight stenosis (p = 0.004). Aspirin was the most antiplatelet therapy used (95.5%). Statin therapy was used in 91% of patients. The mean duration of hospitalization was 12.5 days with a mortality rate of 7.1%. Conclusions: Our study showed that extra carotid atherosclerosis was the most common cause of ischemic stroke in Burkina Faso. Man gender was most represented than women. 展开更多
关键词 ISCHEMIC STROKE EXTRACRANIAL ATHEROSCLEROSIS ANTIPLATELET Therapy Burkina Faso
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肢体缺血后处理改善脑梗死预后和认知障碍 预览
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作者 赵建华 李月娟 +5 位作者 梁可可 时雅辉 宋金玲 陈帅 葛云丽 胡亚梅 《国际神经病学神经外科学杂志》 2019年第3期268-274,共7页
目的观察肢体缺血后处理(RIPostC)对急性脑梗死神经功能的治疗作用及其对认知障碍的影响,且探讨适宜的疗程.方法收录发病72h以内、未溶栓的急性前循环梗死患者,随机分为4组,即RIPostC 10d组、RIPostC 14d组和对照10d组、对照14d组,并分... 目的观察肢体缺血后处理(RIPostC)对急性脑梗死神经功能的治疗作用及其对认知障碍的影响,且探讨适宜的疗程.方法收录发病72h以内、未溶栓的急性前循环梗死患者,随机分为4组,即RIPostC 10d组、RIPostC 14d组和对照10d组、对照14d组,并分别进行4个循环的充气和放气.比较美国国立卫生研究院卒中量表(NIHSS)评分、脑梗死体积(入院时、10d时、14d时和90d时),改良Rankin量表(mRS)评分(入院时、90d时良好转归率),简易智能精神状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)(14d时、90d时认知障碍率).结果纳入89例符合标准的急性脑梗死患者(44例RIPostC组,45例对照组),在RIPostC 10d组中仅有1例不能耐受而放弃治疗,对照组完全耐受.在对照组中,3名患者复发脑梗死(分别为30 d时、65d时和78d时),而在RIPostC各亚组中均没有发生任何相关的心脑血管事件.在90d时,与对照10d组和对照14d组相比,RIPostC 10d组和RIPostC 14d组的NIHSS评分均显著性降低(P<0.05);梗死体积分别减少33.7%和37.2%,差异有统计学意义(P<0.05);mRS的良好转归率明显增高(P<0.05);MoCA、MMSE认知障碍率显著性降低(P<0.05).与RIPostC 10d组相比,RIPostC 14d组中NIHSS评分、mRS的良好转归率无明显变化,差异无统计学意义(P>0.05).结论急性脑梗死后进行RIPostC具有很好的耐受性、安全性及可行性,能减少脑梗死体积,减少残疾,改善预后.同时,也能够改善脑梗死后认知功能障碍.但RIPostC 10d和14d对脑梗死神经功能的治疗作用及其对认知障碍的影响无显著差别,所以,RIPostC治疗10d是较为合适的治疗疗程. 展开更多
关键词 脑梗死 远端肢体缺血后处理 美国国立卫生研究院卒中量表 改良Rankin量表 蒙特利尔认知评估量表 简易智能精神状态检査量表
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多模态磁共振成像评估急性缺血性卒中缺血半暗带的研究进展 预览
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作者 何浩然 俎中良 刘勇 《中国卒中杂志》 2019年第8期842-847,共6页
急性缺血性卒中(acute ischemic stroke,AIS)的缺血半暗带(ischemic penumbra,IP)一直是急性血管内介入治疗中影像评估关注的重点和热点问题.由于多模态MRI可以提供丰富的病理生理学参数,在IP临床评估中具有良好前景.本文对各类MRI成像... 急性缺血性卒中(acute ischemic stroke,AIS)的缺血半暗带(ischemic penumbra,IP)一直是急性血管内介入治疗中影像评估关注的重点和热点问题.由于多模态MRI可以提供丰富的病理生理学参数,在IP临床评估中具有良好前景.本文对各类MRI成像策略对于IP评估的特点与局限进行介绍,重点介绍了新型技术酰胺质子转移成像(amide proton transfer,APT).APT通过对脑缺血区域细胞内pH值的精确判断,能够准确评估IP.虽然目前APT临床应用尚少,但随着其成像技术的不断改进,有望成为辅助决策AIS患者治疗的重要影像学检查手段. 展开更多
关键词 缺血性卒中 磁共振成像 酰胺质子转移成像 缺血半暗带
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3.0T MRI颈动脉斑块高分辨成像在IS患者中的应用价值分析 预览
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作者 朱燕 熊维 殷云志 《中国CT和MRI杂志》 2019年第11期7-9,共3页
目的采用3.0T MRI颈动脉斑块高分辨成像评价缺血性脑卒中(IS)患者高危斑块特征及其与IS的关系。方法将我院90例IS患者作为研究对象,均进行颈动脉3.0TMRI多序列检查,分析比较症状侧和非症状侧颈动脉斑块负荷、斑块内成分及体积。结果症... 目的采用3.0T MRI颈动脉斑块高分辨成像评价缺血性脑卒中(IS)患者高危斑块特征及其与IS的关系。方法将我院90例IS患者作为研究对象,均进行颈动脉3.0TMRI多序列检查,分析比较症状侧和非症状侧颈动脉斑块负荷、斑块内成分及体积。结果症状侧平均血管总面积(TVAmean)和非症状侧无显著差异(P>0.05),平均管腔面积(LAmean)、最小管腔面积(LAmin)均小于非症状侧(P<0.05),平均管壁面积(WAmean)、最大管壁厚度(WTmax)、平均管壁标准化指数(NWImean)、最大管壁标准化指数(NWImax)均大于非症状侧(P<0.05)。症状侧颈动脉斑块钙化、富含脂质的坏死核、斑块内出血比例均高于非症状侧(P<0.05),纤维帽破裂比例与非症状侧无显著差异(P>0.05)。症状侧颈动脉斑块钙化、富含脂质的坏死核及斑块内出血体积均大于非症状侧(P<0.05)。结论IS的发生与同侧颈动脉粥样硬化负荷、斑块内成分有关,3.0TMRI颈动脉斑块高分辨成像能有效测量IS患者颈动脉斑块负荷、斑块内成分,可作为高危斑块识别重要检测方法。 展开更多
关键词 高分辨磁共振成像 缺血性脑卒中 颈动脉粥样硬化 颅内急性缺血病灶
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丁苯酞对缺血性脑卒中缺血半暗带细胞因子及神经功能的影响 预览
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作者 于晓云 《中国实用神经疾病杂志》 2019年第1期51-55,共5页
目的探讨丁苯酞对缺血性脑卒中患者影像学、血液生化指标及神经功能的相关影响。方法2016-01—2017-12至许昌市中心医院就诊的98例缺血性脑卒中患者为研究对象,根据患者就诊的时间顺序分为对照组和观察组各49例,对照组内给予常规及血栓... 目的探讨丁苯酞对缺血性脑卒中患者影像学、血液生化指标及神经功能的相关影响。方法2016-01—2017-12至许昌市中心医院就诊的98例缺血性脑卒中患者为研究对象,根据患者就诊的时间顺序分为对照组和观察组各49例,对照组内给予常规及血栓通静滴,观察组内则相同基础上给予丁苯酞治疗,比较组间患者治疗前后的缺血带变化、炎症细胞因子的表达及神经功能。结果干预后观察组患者的缺血低灌注区域及缺血中心区的面积均显著低于对照组,差异有统计学意义(P<0.05);治疗后观察组与对照组内低灌注区分别占44例及45例,其中存在缺血半暗带分别为33例(75.0%)、16例(35.6%)(P=0.025);经治疗后观察组患者的外周血炎症细胞因子表达水平显著低于对照组(P<0.05);CSS评分结果比较显示干预前患者的神经功能损害水平基本一致(P=0.47),治疗后1周组内比较均明显好转,对照组内治疗后1周及2周相比无显著性差异,观察组内治疗后2周患者的神经功能水平显著优于1周时。结论对于缺血性脑卒中患者使用丁苯酞能够对缺血半暗带进行有效保护,降低炎症细胞因子的表达水平,改善患者的神经功能,有利于患者的临床预后。 展开更多
关键词 缺血性脑卒中 脑梗死 丁苯酞 缺血半暗带 细胞因子 神经功能
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MRI评估缺血性脑卒中患者颈动脉粥样硬化斑块成分及负荷与缺血征象的相关性 预览
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作者 戴志成 宿艳 +3 位作者 张静 何丽 刘学武 曹永贵 《中国CT和MRI杂志》 2019年第11期26-28,共3页
目的探讨MRI评估缺血性脑卒中患者颈动脉粥样硬化斑块成分及负荷与缺血征象的相关性。方法选取我院收治的缺血性脑卒中患者67例,收集影像学资料,依据是否出现缺血征象区分患者卒中侧、非卒中侧,比较不同颈动脉侧斑块成分发生情况及体积... 目的探讨MRI评估缺血性脑卒中患者颈动脉粥样硬化斑块成分及负荷与缺血征象的相关性。方法选取我院收治的缺血性脑卒中患者67例,收集影像学资料,依据是否出现缺血征象区分患者卒中侧、非卒中侧,比较不同颈动脉侧斑块成分发生情况及体积、斑块负荷指标水平。结果本组研究共获得126侧颈动脉图像,卒中侧79根,非卒中侧47根。非卒中侧含有脂质的坏死核、斑块内出血发了率明显低于卒中侧(P<0.05);卒中侧含有脂质的坏死核及斑块内出血体积明显大于非卒中侧(P<0.05);不同侧血管总面积、管腔面积、最小管腔面积指标比较无明显差异(P>0.05);卒中侧管壁面积、管壁厚度、管壁标准化指数、最大管壁面积、最大管壁厚度、最大管壁标准化指数明显高于非卒中侧(P<0.05)。结论MRI各序列扫描可有效评估缺血性脑卒中患者颈动脉粥样硬化斑块成分及负荷情况,成分复杂或负荷越高者缺血征象出现率越高。 展开更多
关键词 MRI 缺血性脑卒中 颈动脉粥样硬化斑块成分 负荷 缺血征象 相关性
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同型半胱氨酸水平与缺血性脑卒中的相关性研究 预览 被引量:1
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作者 张汉卿 闫福岭 《东南大学学报:医学版》 CAS 2019年第1期77-80,共4页
目的:探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑卒之间的关系。方法:分别测定140例缺血性脑卒中患者、100例健康对照者血浆Hcy浓度。结果:缺血性脑卒中患者血浆Hcy水平明显高于健康对照组(P<0.01),其中中青年患者血浆Hcy水平又高于... 目的:探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑卒之间的关系。方法:分别测定140例缺血性脑卒中患者、100例健康对照者血浆Hcy浓度。结果:缺血性脑卒中患者血浆Hcy水平明显高于健康对照组(P<0.01),其中中青年患者血浆Hcy水平又高于老年患者(P<0.01);缺血性脑卒中不同亚型血浆Hcy水平差异无统计学意义(P>0.05)。结论:血浆高Hcy血症(Hyperhomocysteinaemia,HHcy)是缺血性脑卒中重要危险因素,尤对中青年缺血性脑卒中组的影响最为显著,血浆Hcy水平与不同脑卒中亚型无相关性。 展开更多
关键词 同型半胱氨酸 中青年 缺血性脑卒中 短暂性脑缺血发作
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不同等级医院缺血性脑血管病二级预防药物依从性研究
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作者 姜悦 王晨 +2 位作者 李子孝 杨晓萌 潘岳松 《临床药物治疗杂志》 2019年第8期35-39,共5页
目的:探讨不同层级医疗机构急性缺血性脑卒中(actue ischemic stroke,AIS)和短暂性脑缺血发作(transient ischemic attack,TIA)患者二级预防药物依从性的差异,以期探讨改善药物依从性的方法。方法:全国219家医疗机构急性缺血性卒中和短... 目的:探讨不同层级医疗机构急性缺血性脑卒中(actue ischemic stroke,AIS)和短暂性脑缺血发作(transient ischemic attack,TIA)患者二级预防药物依从性的差异,以期探讨改善药物依从性的方法。方法:全国219家医疗机构急性缺血性卒中和短暂性脑缺血发作的住院患者25 018例,在发病后3、6及12个月对患者药物依从性及预后进行随访。使用logistic回归分析对影响药物依从性进行多因素分析。结果:最终16 489例AIS和TIA患者完成12个月的随访。经多因素分析,二级医院就诊的卒中患者6个月药物总体依从性优于三级医院就诊的患者,校正OR为1.185(95%CI:1.030~1.363),3个月和12个月时差异无统计学意义。结论:二级医院在维持缺血性卒中/TIA患者二级预防药物依从性方面发挥了积极的作用。 展开更多
关键词 缺血性脑卒中 短暂性脑缺血发作 二级预防 药物依从性
Wall shear stress can improve prediction accuracy for transient ischemic attack 预览
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作者 Qiu-Yun Liu Qi Duan +3 位作者 Xiao-Hong Fu Mei Jiang Hong-Wei Xia Yong-Lin Wan 《世界临床病例杂志》 2019年第18期2722-2733,共12页
BACKGROUND Early prediction of transient ischemic attack (TIA) has important clinical value. To date, systematic studies on clinical, biochemical, and imaging indicators related to carotid atherosclerosis have been ca... BACKGROUND Early prediction of transient ischemic attack (TIA) has important clinical value. To date, systematic studies on clinical, biochemical, and imaging indicators related to carotid atherosclerosis have been carried out to predict the occurrence of TIA. However, their prediction accuracy is limited. AIM To explore the role of combining wall shear stress (WSS) with conventional predictive indicators in improving the accuracy of TIA prediction. METHODS A total of 250 patients with atherosclerosis who underwent carotid ultrasonography at Naval Military Medical University Affiliated Gongli Hospital were recruited. Plaque location, plaque properties, stenosis rate, peak systolic velocity, and end diastolic velocity were measured and recorded. The WSS distribution map of the proximal and distal ends of the plaque shoulder was drawn using the shear stress quantitative analysis software, and the average values of WSS were recorded. The laboratory indicators of the subjects were recorded. The patients were followed for 4 years. Patients with TIA were included in a TIA group and the remaining patients were included in a control group. The clinical data, laboratory indicators, and ultrasound characteristics of the two groups were analyzed. Survival curves were plotted by the Kaplan-Meier method. Receiver operating characteristic curves were established to evaluate the accuracy of potential indicators in predicting TIA. Logistic regression model was used to establish combined prediction, and the accuracy of combined predictive indicators for TIA was explored.RESULTS The intraclass correlation coefficients of the WSS between the proximal and distal ends of the plaque shoulder were 0.976 and 0.993, respectively, which indicated an excellent agreement. At the end of the follow-up, 30 patients suffered TIA (TIA group) and 204 patients did not (control group). Hypertension (P = 0.037), diabetes (P = 0.026), homocysteine (Hcy)(P = 0.022), fasting blood glucose (P = 0.034), plaque properties (P = 0.000), luminal stenosis rat 展开更多
关键词 TRANSIENT ISCHEMIC ATTACK Acute ISCHEMIC STROKE Wall shear stress ATHEROSCLEROSIS PLAQUE
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Clinical characteristics and treatment strategies of acute ischemic stroke with internal carotid artery occlusion: a case report 预览
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作者 Yi Bao Lixia Ma +2 位作者 Xiaodong Liu Guangjian Liu Ying Wang 《转化神经科学电子杂志(英文)》 2019年第2期31-38,共8页
Acute ischemic stroke has the characteristics of high disability,lethality and recurrence rate,which seriously threatens the health of middle-aged and elderly people.This article describes the acute ischemic stroke wi... Acute ischemic stroke has the characteristics of high disability,lethality and recurrence rate,which seriously threatens the health of middle-aged and elderly people.This article describes the acute ischemic stroke with internal carotid artery occlusion as the main clinical feature and discusses its treatment strategy.Treatment remedies:clinical diagnosis was carried out based on the present medical history,physical examination and craniocerebral CT(computed tomography).Neurological function was improved by intravenous thrombolysis,cerebrovascular angiography was used to clarify cerebrovascular occlusion,cerebral blood supply was identified by CT perfusion,and neurological function recovery was followed up.After intravenous thrombolysis,the patient’s consciousness turned clear and the right limb muscle strength recovery was not obvious,but the patient did not receive bridging therapy.Cerebral angiography showed about 90%stenosis at the beginning of the left internal carotid artery,and the blood flow terminated at the C7 segment.Cerebral CT perfusion imaging showed decreased perfusion in the left cerebral hemisphere,but the patient did not receive carotid endarterectomy and vascular bypass treatment.Post treatment evaluating:follow-up showed that NIHSS(National Institute of Health stroke scale)score was significantly decreased and limb function was significantly restored.Conclusion:early intravenous thrombolytic therapy can help reduce the area of ischemic penumbra and improve long-term prognosis.Severe vascular stenosis can stimulate vascular compensation,significantly reduce the range of ischemia when thrombus occurs,and effectively reduce the disability rate without bridging therapy.Whether vascular stenosis and occlusion are treated by vascular bypass,etc.,individualized plans should be made according to vascular compensation. 展开更多
关键词 acute ischemic stroke internal carotid artery occlusion intravenous thrombolysis digital substraction angiography(DSA) carotid endarterectomy ischemic penumbra
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丁苯酞对缺血性脑卒中缺血半暗带细胞因子及神经功能的影响 预览
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作者 布茂振 《中国医药指南》 2019年第24期11-13,共3页
目的探讨丁苯酞对缺血性脑卒中缺血半暗带细胞因子及神经功能的影响。方法选取我院(2016年1月至2018年1月)收治的缺血性脑卒中患者110例,分为两组,对照组(n=55)接受血栓通治疗,观察组(n=55)再对照组基础上接受丁苯酞治疗,对比两组患者... 目的探讨丁苯酞对缺血性脑卒中缺血半暗带细胞因子及神经功能的影响。方法选取我院(2016年1月至2018年1月)收治的缺血性脑卒中患者110例,分为两组,对照组(n=55)接受血栓通治疗,观察组(n=55)再对照组基础上接受丁苯酞治疗,对比两组患者治疗前后神经功能、缺血中心区和缺血低灌注区面积、炎性细胞因子表达以及不良反应发生率。结果治疗后两组患者CSS评分均明显下降,观察组改善更为明显,差异具有统计学意义(P<0.05)。治疗前两组患者缺血中心区和缺血低灌注区面积对比差异不明显(P>0.05);治疗后观察组缺血中心区和缺血低灌注区面积明显大于对照组,差异具有统计学意义(P<0.05)。治疗前两组患者IL-1β、CRP、TNF-α、IL-6水平对比差异不明显(P>0.05);治疗后观察组IL-1β、CRP、TNF-α、IL-6水平明显低于对照组,明显具有统计学意义(P<0.05)。观察组不良反应发生率9.09%稍高于对照组5.45%,但差异不明显,无统计学意义(P>0.05)。结论丁苯酞可有效降低缺血性脑卒中患者的炎性因子表达,保护缺血半暗带,并且安全性高,有利于患者预后,值得临床推广。 展开更多
关键词 丁苯酞 缺血性脑卒中 缺血半暗带 细胞因子 神经功能
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基于缺血性脑卒中的中医诊断思维研究 预览
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作者 傅小欧 海霞 张运克 《世界中西医结合杂志》 2019年第10期1467-1470,共4页
中医诊断学的基本特征之一是辨证治疗。在中医诊断的整个过程是在整体观念指导下进行的,其辨别的内容除了辨病、辨证、辨症之外,还要考虑个体的差异、疾病发生发展的机制以及病、证的动态变化。缺血性脑卒中(又名缺血性脑中风)是最常见... 中医诊断学的基本特征之一是辨证治疗。在中医诊断的整个过程是在整体观念指导下进行的,其辨别的内容除了辨病、辨证、辨症之外,还要考虑个体的差异、疾病发生发展的机制以及病、证的动态变化。缺血性脑卒中(又名缺血性脑中风)是最常见的临床危重疾病之一,属中医“中风”范畴,不同时代的医家对其病因和发病机制有不同的看法。经过梳理发现,大多数现代学者对脑卒中的致病因素概括为风、痰、虚、瘀、气、火,诊断标准也逐步趋于统一。基于缺血性脑卒中病,研究和理解中医诊断思维的规律性认识,对未来临床中诊断辨证非常有益。 展开更多
关键词 缺血性脑卒中 缺血性中风 中医诊断 辨证论治
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磁敏感加权成像在大鼠缺血性卒中缺血半暗带中的预测价值研究
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作者 张盼盼 牛智领 +5 位作者 闫斌 刘素梅 葛晓航 彭霈 刘乐喜 刘远洪 《中华生物医学工程杂志》 CAS 2019年第4期411-414,共4页
目的研究磁敏感加权成像(SWI)在大鼠缺血性卒中缺血半暗带中的预测价值.方法将30只SD大鼠参照改良Longa法制备脑动脉缺血再灌注模型.造模成功后,采用磁共振机器进行扫描,分别扫描其扩散加权成像(DWI)、SWI和磁共振灌注造影成像(PWI)序列... 目的研究磁敏感加权成像(SWI)在大鼠缺血性卒中缺血半暗带中的预测价值.方法将30只SD大鼠参照改良Longa法制备脑动脉缺血再灌注模型.造模成功后,采用磁共振机器进行扫描,分别扫描其扩散加权成像(DWI)、SWI和磁共振灌注造影成像(PWI)序列,采用2,3,5-三苯基氯化四氮唑(TTC)法检测脑组织梗死面积;采用Person相关性分析SWI与PWI检测之间的相关性,采用Kappa一致性检验SWI检测缺血半暗带的准确率、灵敏度、特异性、阳性预测、阴性预测和Kappa值;采用受试者工作特征(ROC)曲线分析SWI对缺血半暗带的预测价值,曲线下面积(AUC)表示诊断的准确度.结果SWI与PWI的脑组织ASPECTS评分和DWI不匹配区域呈显著正相关关系(r=0.795,P=0.000;r=0.812,P=0.000);采用一致性分析,SWI诊断缺血半暗带的灵敏度为92.00%,特异度为100.00%,准确率为93.33%,阳性预测值为100.00%,阴性预测值为71.43%,Kappa值为0.793;ROC分析显示,SWI诊断大鼠缺血性卒中缺血半暗带的AUC为0.933.结论SWI对大鼠缺血性卒中的缺血半暗带具有较高的预测价值. 展开更多
关键词 缺血性脑卒中 磁敏感加权成像 缺血半暗带
短暂症状性脑梗死临床特征及发病机制的研究进展 预览
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作者 邹巧鸽 黄华晨 张忠玲 《医学综述》 2019年第14期2806-2810,共5页
短暂症状性脑梗死(TSI)是近年新出现的组织学定义,指临床症状与短暂性脑缺血发作(TIA)相同,采用弥散加权成像(DWI)可发现病变的一类疾病。TSI、缺血性脑卒中(IS)和TIA的临床、血液化验和影像学的特征具有相似性和差异性,但也有其独特性... 短暂症状性脑梗死(TSI)是近年新出现的组织学定义,指临床症状与短暂性脑缺血发作(TIA)相同,采用弥散加权成像(DWI)可发现病变的一类疾病。TSI、缺血性脑卒中(IS)和TIA的临床、血液化验和影像学的特征具有相似性和差异性,但也有其独特性。TSI作为独立疾病,其复发率远高于IS和TIA。DWI显示相似梗死改变患者的临床表现和预后存在差异,但具体机制尚不清楚。TSI可能与微栓子、脑白质病变、脑储备等有关,TSI阳性的相关因素可能与血尿素氮/肌酐比值、血糖、血浆D-二聚体、神经功能缺损症状持续时间、DWI检查时间等有关。 展开更多
关键词 短暂症状性脑梗死 短暂性脑缺血发作 缺血性脑卒中 弥散加权成像
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