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Strategies to prevent and detect intraoperative spinal cord ischemia during complex aortic surgery:from drainages and biomarkers 认领
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作者 Alexander Gombert Florian Simon 《中国神经再生研究:英文版》 SCIE CAS 2021年第4期678-679,共2页
Spinal cord ischemia(SCI),a frequent complication following open and endovascular thoracoabdominal aortic aneurysm(TAAA)repair,is a feared complication with relevant impact on a patient's quality of life.In the ea... Spinal cord ischemia(SCI),a frequent complication following open and endovascular thoracoabdominal aortic aneurysm(TAAA)repair,is a feared complication with relevant impact on a patient's quality of life.In the early days of open TAAA repair,more than one third of the patients suffered from SCI.Nowadays,due to improved preventive measures and the option of staged endovascular TAAA repair,10%of all patients are affected by spinal cord problems after TAAA repair(Rocha et al.,2020). 展开更多
关键词 ISCHEMIA AORTIC SCI
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激素性股骨头缺血坏死发病机制中的内质网应激 认领
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作者 张煦坚 赵振群 刘万林 《中国组织工程研究》 CAS 北大核心 2021年第11期1759-1765,共7页
背景:激素性股骨头缺血坏死的发病机制尚不明确,可能与内质网应激有关,控制内质网应激信号通路可能调控细胞的自噬与凋亡,对该病具有一定的防治作用。目的:通过探讨内质网应激与激素引起的细胞自噬、细胞凋亡的相互关系,总结内质网应激... 背景:激素性股骨头缺血坏死的发病机制尚不明确,可能与内质网应激有关,控制内质网应激信号通路可能调控细胞的自噬与凋亡,对该病具有一定的防治作用。目的:通过探讨内质网应激与激素引起的细胞自噬、细胞凋亡的相互关系,总结内质网应激在激素性股骨头缺血坏死发病机制中的研究进展。方法:检索2000至2020年相关文献,以“内质网应激,股骨头坏死,未折叠蛋白反应,糖皮质激素,自噬,凋亡,缺血”为中文检索词检索CNKI、万方、维普数据库;以“endoplasmic reticulum stress,femur head necrosis,unfolded protein response,glucocorticoid,autophagy,apoptosis,ischaemia”为英文检索词检索PubMed、Web of science数据库。排除重复和较陈旧的文献及Meta分析,共81篇文献符合纳入标准。结果与结论:①未折叠蛋白反应为缓解内质网应激引发的3条下游信号通路可使细胞发生自噬和凋亡;②内质网应激与激素诱导的细胞自噬和凋亡及股骨头缺血有密切联系;③内质网应激可能是激素性股骨头缺血坏死发生过程中的病理环节,激素通过让细胞缺血缺氧激发内质网应激进而诱导细胞的自噬与凋亡,最终导致股骨头坏死。 展开更多
关键词 内质网应激 股骨头坏死 未折叠蛋白反应 糖皮质激素 自噬 凋亡 缺血
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Modeling subcortical ischemic white matter injury in rodents:unmet need for a breakthrough in translational research 认领
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作者 Yuexian Cui Xuelian Jin +1 位作者 Jun Young Choi Byung Gon Kim 《中国神经再生研究:英文版》 SCIE CAS 2021年第4期638-642,共5页
Subcortical ischemic white matter injury(SIWMI),pathological correlate of white matter hyperintensities or leukoaraiosis on magnetic resonance imaging,is a common cause of cognitive decline in elderly.Despite its high... Subcortical ischemic white matter injury(SIWMI),pathological correlate of white matter hyperintensities or leukoaraiosis on magnetic resonance imaging,is a common cause of cognitive decline in elderly.Despite its high prevalence,it remains unknown how various components of the white matter degenerate in response to chronic ischemia.This incomplete knowledge is in part due to a lack of adequate animal model.The current review introduces various SIWMI animal models and aims to scrutinize their advantages and disadvantages primarily in regard to the pathological manifestations of white matter components.The SIWMI animal models are categorized into 1)chemically induced SIWMI models,2)vascular occlusive SIWMI models,and 3)SIWMI models with comorbid vascular risk factors.Chemically induced models display consistent lesions in predetermined areas of the white matter,but the abrupt evolution of lesions does not appropriately reflect the progressive pathological processes in human white matter hyperintensities.Vascular occlusive SIWMI models often do not exhibit white matter lesions that are sufficiently unequivocal to be quantified.When combined with comorbid vascular risk factors(specifically hypertension),however,they can produce progressive and definitive white matter lesions including diffuse rarefaction,demyelination,loss of oligodendrocytes,and glial activation,which are by far the closest to those found in human white matter hyperintensities lesions.However,considerable surgical mortality and unpredictable natural deaths during a follow-up period would necessitate further refinements in these models.In the meantime,in vitro SIWMI models that recapitulate myelinated white matter track may be utilized to study molecular mechanisms of the ischemic white matter injury.Appropriate in vivo and in vitro SIWMI models will contribute in a complementary manner to making a breakthrough in developing effective treatment to prevent progression of white matter hyperintensities. 展开更多
关键词 animal model axonal degeneration DEMYELINATION hypertension ischemia OLIGODENDROCYTES subcortical ischemic white matter injury vascular cognitive impairment white matter hyperintensities
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Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia 认领
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作者 Qiang Gao Aaron Leung +5 位作者 Yong-Hong Yang Benson Wui-Man Lau Qian Wang Ling-Yi Liao Yun-Juan Xie Cheng-Qi He 《中国神经再生研究:英文版》 SCIE CAS 2021年第7期1252-1257,共6页
Extremely low frequency electromagnetic fields(ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer's disease, however, its effect on cerebral ischemia remains poorly understood.In this s... Extremely low frequency electromagnetic fields(ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer's disease, however, its effect on cerebral ischemia remains poorly understood.In this study, we established rat models of middle cerebral artery occlusion/reperfusion.One day after modeling, a group of rats were treated with ELF-EMF(50 Hz, 1 mT) for 2 hours daily on 28 successive days.Our results showed that rats treated with ELF-EMF required shorter swimming distances and latencies in the Morris water maze test than those of untreated rats.The number of times the platform was crossed and the time spent in the target quadrant were greater than those of untreated rats.The number of BrdU~+/NeuN~+ cells, representing newly born neurons, in the hippocampal subgranular zone increased more in the treated than in untreated rats.Up-regulation in the expressions of Notch1, Hes1, and Hes5 proteins, which are the key factors of the Notch signaling pathway, was greatest in the treated rats.These findings suggest that ELF-EMF can enhance hippocampal neurogenesis of rats with cerebral ischemia, possibly by affecting the Notch signaling pathway.The study was approved by the Institutional Ethics Committee of Sichuan University, China(approval No.2019255A) on March 5, 2019. 展开更多
关键词 cerebral ischemia cognitive function electromagnetic fields HIPPOCAMPUS NEUROGENESIS PLASTICITY repair signaling pathway STROKE rat
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益气活血中药联合骨髓间充质干细胞促进缺血性脑卒中血管新生的作用与机制 认领
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作者 樊飞燕 张运克 《中国组织工程研究》 CAS 北大核心 2021年第13期2060-2069,共10页
背景:骨髓间充质干细胞具有促进血管新生的作用,治疗缺血性脑卒中效果良好,益气活血类中药在促进血管新生方面亦存在显著疗效。目的:综述益气活血类中药联合骨髓间充质干细胞促进缺血性脑卒中血管新生的机制,以期为缺血性脑卒中的研究... 背景:骨髓间充质干细胞具有促进血管新生的作用,治疗缺血性脑卒中效果良好,益气活血类中药在促进血管新生方面亦存在显著疗效。目的:综述益气活血类中药联合骨髓间充质干细胞促进缺血性脑卒中血管新生的机制,以期为缺血性脑卒中的研究及治疗提供参考。方法:以“bone marrow mesenchymal stem cells,angiogenesis,ischemic stroke,traditional chinese medicine”为英文关键词,以“骨髓间充质干细胞,血管新生,缺血性脑卒中,中药”为中文关键词,检索2009至2020年期间收录在PubMed、中国知网、万方数据库中的文献,纳入血管新生相关机制及中药联合骨髓间充质干细胞促进血管新生相关的文献,排除重复与相关性弱的文献,对145篇文献进行总结分析。结果与结论:①梳理了骨髓间充质干细胞、血管新生的定义及血管新生的机制;②总结了益气活血类中药联合骨髓间充质干细胞促进血管新生的相关因子及信号通路,如血管内皮生长因子、脑源性神经营养因子、碱性成纤维细胞生长因子、缺氧诱导因子1α、血管生成素、整合素αvβ3、基质金属蛋白酶9及Wnt信号通路、Notch信号通路、PI3K/Akt信号通路和SDF-1/CXCR4信号轴;③总结发现益气活血类中药与骨髓间充质干细胞联合应用能增强血管新生作用,提升缺血性脑卒中的治疗效果。 展开更多
关键词 干细胞 骨髓间充质干细胞 血管新生 脑卒中 缺血性 中药 复方 综述
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Hydroxyethylstarch revisited for acute brain injury treatment 认领
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作者 Martin A.Schick Malgorzata Burek +3 位作者 Carola Y.Förster Michiaki Nagai Christian Wunder Winfried Neuhaus 《中国神经再生研究:英文版》 SCIE CAS 2021年第7期1372-1376,共5页
Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss.In the last decade it was revealed that hydroxyethylstarch c... Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss.In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients.Because of the serious risk for critically ill patients, the administration of hydroxyethylstarch was restricted for clinical use.Animal studies and recently published in vitro experiments showed that hydroxyethylstarch might exert protective effects on the blood-brain barrier.Since the prevention of blood-brain barrier disruption was shown to go along with the reduction of brain damage after several kinds of insults, we revisit the topic hydroxyethylstarch and discuss a possible niche for the application of hydroxyethylstarch in acute brain injury treatment. 展开更多
关键词 acute subarachnoid hemorrhage ASTROCYTE chronic kidney disease delayed cerebral ischemia MICROGLIA neurovascular unit osmotic pressure PERICYTE STROKE traumatic brain injury
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Genes associated with Alzheimer's disease affecting ischemic neurodegeneration of the hippocampal CA3 region 认领
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作者 Ryszard Pluta Marzena Ułamek-Kozioł 《中国神经再生研究:英文版》 SCIE CAS 2021年第7期1392-1393,共2页
Neurodegeneration in the brain after ischemia with reperfusion mimicking the neuropathology of Alzheimer's disease:Brain ischemia with reperfusion,which is one of the main causes of morbidity and mortality in the ... Neurodegeneration in the brain after ischemia with reperfusion mimicking the neuropathology of Alzheimer's disease:Brain ischemia with reperfusion,which is one of the main causes of morbidity and mortality in the world,triggers various neuropathological changes characteristic for Alzheimer's disease(AD)such as increased blood-brain barrier permeability,excitotoxicity,necrosis,autophagy,mitophagy,apoptosis,neuroinflammation,amyloid plaques,neurofibrillary tangles,cerebral vessel pathology,and brain atrophy that lead to the death of neurons,deteriorating motor,sensory and cognitive functions(Figure 1)(Kato et al.,1988;Wisniewski et al.,1995;Van Groen et al.,2005;Kocki et al.,2015;Ułamek-Koziołet al.,2016,2017,2019).Brain ischemia is recognized as a major contributor to the dysfunction of an aging brain and the development of neurodegenerative diseases,including AD(Pluta,2019). 展开更多
关键词 ALZHEIMER ISCHEMIA cerebral
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Effect of electroacupuncture on glial fibrillary acidic protein and nerve growth factor in the hippocampus of rats with hyperlipidemia and middle cerebral artery thrombus 认领
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作者 Na-Ying Xue Dong-Yu Ge +3 位作者 Rui-Juan Dong Hyung-Hwan Kim Xiu-Jun Ren Ya Tu 《中国神经再生研究:英文版》 SCIE CAS 2021年第1期137-142,共6页
Electroacupuncture(EA)has been shown to reduce blood lipid level and improve cerebral ischemia in rats with hyperlipemia complicated by cerebral ischemia.However,there are few studies on the results and mechanism of t... Electroacupuncture(EA)has been shown to reduce blood lipid level and improve cerebral ischemia in rats with hyperlipemia complicated by cerebral ischemia.However,there are few studies on the results and mechanism of the effect of EA in reducing blood lipid level or promoting neural repair after stroke in hyperlipidemic subjects.In this study,EA was applied to a rat model of hyperlipidemia and middle cerebral artery thrombosis and the condition of neurons and astrocytes after hippocampal injury was assessed.Except for the normal group,rats in other groups were fed a high-fat diet throughout the whole experiment.Hyperlipidemia models were established in rats fed a high-fat diet for 6 weeks.Middle cerebral artery thrombus models were induced by pasting 50%FeCl3 filter paper on the left middle cerebral artery for 20 minutes on day 50 as the model group.EA1 group rats received EA at bilateral ST40(Fenglong)for 7 days before the thrombosis.Rats in the EA1 and EA2 groups received EA at GV20(Baihui)and bilateral ST40 for 14 days after model establishment.Neuronal health was assessed by hematoxylin-eosin staining in the brain.Hyperlipidemia was assessed by biochemical methods that measured total cholesterol,triglyceride,low-density lipoprotein and high-density lipoprotein in blood sera.Behavioral analysis was used to confirm the establishment of the model.Immunohistochemical methods were used to detect the expression of glial fibrillary acidic protein and nerve growth factor in the hippocampal CA1 region.The results demonstrated that,compared with the model group,blood lipid levels significantly decreased,glial fibrillary acidic protein immunoreactivity was significantly weakened and nerve growth factor immunoreactivity was significantly enhanced in the EA1 and EA2 groups.The repair effect was superior in the EA1 group than in the EA2 group.These findings confirm that EA can reduce blood lipid,inhibit glial fibrillary acidic protein expression and promote nerve growth factor expression in the hippocampal CA1 region after 展开更多
关键词 ASTROCYTES CA1 cerebral ischemia ELECTROACUPUNCTURE glial fibrillary acidic protein hematoxylin-eosin staining HIPPOCAMPUS HYPERLIPIDEMIA immunohistochemistry nerve growth factor
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MicroRNA-670 aggravates cerebral ischemia/reperfusion injury via the Yap pathway 认领
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作者 Shi-Jia Yu Ming-Jun Yu +2 位作者 Zhong-Qi Bu Ping-Ping He Juan Feng 《中国神经再生研究:英文版》 SCIE CAS 2021年第6期1024-1030,共7页
Apoptosis is an important programmed cell death process involved in ischemia/reperfusion injury.MicroRNAs are considered to play an important role in the molecular mechanism underlying the regulation of cerebral ische... Apoptosis is an important programmed cell death process involved in ischemia/reperfusion injury.MicroRNAs are considered to play an important role in the molecular mechanism underlying the regulation of cerebral ischemia and reperfusion injury.However,whether miR-670 can regulate cell growth and death in cerebral ischemia/reperfusion and the underlying mechanism are poorly understood.In this study,we established mouse models of transient middle artery occlusion and Neuro 2a cell models of oxygen-glucose deprivation and reoxygenation to investigate the potential molecular mechanism by which miR-670 exhibits its effects during cerebral ischemia/reperfusion injury both in vitro and in vivo.Our results showed that after ischemia/reperfusion injury,miR-670 expression was obviously increased.After miR-670 expression was inhibited with an miR-670 antagomir,cerebral ischemia/reperfusion injury-induced neuronal death was obviously reduced.When miR-670 overexpression was induced by an miR-670 agomir,neuronal apoptosis was increased.In addition,we also found that miR-670 could promote Yap degradation via phosphorylation and worsen neuronal apoptosis and neurological deficits.Inhibition of miR-670 reduced neurological impairments after cerebral ischemia/reperfusion injury.These results suggest that microRNA-670 aggravates cerebral ischemia/reperfusion injury through the Yap pathway,which may be a potential target for treatment of cerebral ischemia/reperfusion injury.The present study was approved by the Institutional Animal Care and Use Committee of China Medical University on February 27,2017(IRB No.2017PS035K). 展开更多
关键词 APOPTOSIS cerebral ischemia and reperfusion injury MICRORNA miR-670 neurological function NEURON non-coding RNA PATHWAY
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Microglial activation and adult neurogenesis after brain stroke 认领
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作者 Ijair R.C.dos Santos Michelle Nerissa C.Dias Walace Gomes-Leal 《中国神经再生研究:英文版》 SCIE CAS 2021年第3期456-459,共4页
The discovery that new neurons are produced in some regions of the adult mammalian brain is a paradigm-shift in neuroscience research.These new-born cells are produced from neuroprogenitors mainly in the subventricula... The discovery that new neurons are produced in some regions of the adult mammalian brain is a paradigm-shift in neuroscience research.These new-born cells are produced from neuroprogenitors mainly in the subventricular zone at the margin of the lateral ventricle,subgranular zone in the hippocampal dentate gyrus and in the striatum,a component of the basal ganglia,even in humans.In the human hippocampus,neuroblasts are produced even in elderlies.The regulation of adult neurogenesis is a complex phenomenon involving a multitude of molecules,neurotransmitters and soluble factors released by different sources including glial cells.Microglia,the resident macrophages of the central nervous system,are considered to play an important role on the regulation of adult neurogenesis both in physiological and pathological conditions.Following stroke and other acute neural disorders,there is an increase in the numbers of neuroblast production in the neurogenic niches.Microglial activation is believed to display both beneficial and detrimental role on adult neurogenesis after stroke,depending on the activation level and brain location.In this article,we review the scientific evidence addressing the role of microglial activation on adult neurogenesis after ischemia.A comprehensive understanding of the microglial role after stroke and other neural disorders it is an important step for development of future therapies based on manipulation of adult neurogenesis. 展开更多
关键词 adult neurogenesis HIPPOCAMPUS ISCHEMIA MICROGLIA NEUROINFLAMMATION NEUROPROTECTION STROKE subventricular zone therapy
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Meta-Analysis of Risk Factors of Vascular Cognitive Disorder in Acute Cerebral Infarction Patients 认领
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作者 Yan Liang Xin Ao 《长江医药(英文)》 2020年第2期97-113,共17页
<strong>Objectives:</strong> To identify the main risk factors of vascular cognitive impairment in patients with acute cerebral infarction by Meta-analysis, and provide references for the effective prevent... <strong>Objectives:</strong> To identify the main risk factors of vascular cognitive impairment in patients with acute cerebral infarction by Meta-analysis, and provide references for the effective prevention of the cognitive impairment in stroke patients. <strong>Methods:</strong> To retrieve the observational research literatures that refer to the risk factors of vascular cognitive impairment in patients with ischemic stroke, which are published on China National Knowledge Infrastructure (CNKI), Wanfang and Weipu Chinese databases. The screening and data extraction of these literatures are independently completed by two researchers, who also give the quality evaluation of the literatures according to the evaluation criterion of the Australian JBI Evidence-Based Health Care Center. Then, Meta-analysis is conducted by using Revman5.3 software. <strong>Results:</strong> There are twenty-eight articles selected from 1507 literatures, with a total of 10,711 cases and 50 risk factors included. Among them, there are combined effects of ten factors which have statistical significance, such as infarction area, alcohol consumption, smoking, hyper homocysteinemia, hypertension, diabetes mellitus, age, history of cerebral infarction, hyperlipoidemia and education level. The relational merging OR value and 95% CI between the type-variable factors and cognitive impairment are 3.25 (1.84, 5.76);2.98 (2.58, 3.45);2.79 (1.69, 4.59);2.35 (1.93, 2.85);2.25 (1.86, 2.71);2.14 (2.10, 2.18);1.82 (1.62, 2.03);1.54 (1.24, 1.92);1.45 (1.34, 1.56);0.83 (0.78, 0.89). <strong>Conclusion: </strong>Infarction area, alcohol consumption, smoking, hyper homocysteinemia, hypertension, diabetesmellitus, age, history of cerebral infarction, hyperlipoidemia and low education level are the main risk factors for vascular cognitive impairment in patients with acute cerebral infarction. Clinical nursing staff should include it into the routine assessment of patients with acute cerebral infarction and actively prevent and intervene. 展开更多
关键词 Cerebral Ischemia Vascular Cognitive Impairment Risk Factors META-ANALYSIS
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Ischemia Modified Albumin and C-Reactive Protein in Children with β-Thalassemia Major 认领
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作者 Wessam M. Moftah Ensaf K. Mohammed +1 位作者 Amal A. Morsy Asmaa A. Ibrahim 《儿科学期刊(英文)》 2020年第3期452-462,共11页
<strong>Background:</strong> <span style="font-family:""><span style="font-family:Verdana;">Beta-thalassemia is a hereditary haemoglobinopathy caused by defective hemog... <strong>Background:</strong> <span style="font-family:""><span style="font-family:Verdana;">Beta-thalassemia is a hereditary haemoglobinopathy caused by defective hemoglobin (Hb) </span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-globin synthesis, leading to excess </span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;">-globin chains that cause hemolysis and impair erythropoiesis. Ischemia modified albumin (IMA) is not a signal protein and not generated in pro-inflammatory state alone but rather an end product of oxidative stress.</span><b><span style="font-family:Verdana;"> Objectives: </span></b><span style="font-family:Verdana;">The aim of the study was to evaluate ischemia modified albumin (IMA) and C-reactive protein (CRP) in children with </span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-thalassemia major and its relation to different iron chelators. </span><b><span style="font-family:Verdana;">Patients and Methods: </span></b><span style="font-family:Verdana;">The study was carried on 40 children diagnosed as beta-thalassemia major recruited from the outpatient clinic and the pediatric department, at Al-Zahraa University Hospital, Faculty of medicine for Girls, Al-Azhar University and EL Minia Insurance Hospital. They were 20 male and 20 female, aged from 4 - 11 years. Another 40 apparently healthy children age and sex matched as control group. CRP and IMA were determined for all participants.</span><b><span style="font-family:Verdana;"> Results:</span></b><span style="font-family:Verdana;"> There were significant increases in serum CRP, IMA and ferritin levels in patients group compared to control group. There were significant decreases of IMA and CRP levels of thalassemic patients on chelation deferiprone (DFP) compared to deferasirox (DFX) P-value (<0.01) for each. There was a significant positive correlation between serum ferritin and both CRP and IMA levels in thalassemic childr 展开更多
关键词 β-Thalassemia Major Ischemia Modified Albumin CRP Oxidative Stress
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Autophagy and inflammation in ischemic stroke 认领 被引量:2
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作者 Yun Mo Yin-Yi Sun Kang-Yong Liu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第8期1388-1396,共9页
Appropriate autophagy has protective effects on ischemic nerve tissue,while excessive autophagy may cause cell death.The inflammatory response plays an important role in the survival of nerve cells and the recovery of... Appropriate autophagy has protective effects on ischemic nerve tissue,while excessive autophagy may cause cell death.The inflammatory response plays an important role in the survival of nerve cells and the recovery of neural tissue after ischemia.Many studies have found an interaction between autophagy and inflammation in the pathogenesis of ischemic stroke.This study outlines recent advances regarding the role of autophagy in the post-stroke inflammatory response as follows.(1)Autophagy inhibits inflammatory responses caused by ischemic stimulation through mTOR,the AMPK pathway,and inhibition of inflammasome activation.(2)Activation of inflammation triggers the formation of autophagosomes,and the upregulation of autophagy levels is marked by a significant increase in the autophagy-forming markers LC3-II and Beclin-1.Lipopolysaccharide stimulates microglia and inhibits ULK1 activity by direct phosphorylation of p38 MAPK,reducing the flux and autophagy level,thereby inducing inflammatory activity.(3)By blocking the activation of autophagy,the activation of inflammasomes can alleviate cerebral ischemic injury.Autophagy can also regulate the phenotypic alternation of microglia through the nuclear factor-κB pathway,which is beneficial to the recovery of neural tissue after ischemia.Studies have shown that some drugs such as resveratrol can exert neuroprotective effects by regulating the autophagy-inflammatory pathway.These studies suggest that the autophagy-inflammatory pathway may provide a new direction for the treatment of ischemic stroke. 展开更多
关键词 AUTOPHAGY cerebral ISCHEMIA function inflammasome INFLAMMATION ischemia/refusion ischemic stroke MACROAUTOPHAGY NEUROINFLAMMATION oxygen glucose DEPRIVATION
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Nomogram for predicting transmural bowel infarction in patients with acute superior mesenteric venous thrombosis 认领
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作者 Meng Jiang Chang-Li Li +4 位作者 Chun-Qiu Pan Wen-Zhi Lv Yu-Fei Ren Xin-Wu Cui Christoph F Dietrich 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第26期3800-3813,共14页
BACKGROUND The prognosis of acute mesenteric ischemia(AMI)caused by superior mesenteric venous thrombosis(SMVT)remains undetermined and early detection of transmural bowel infarction(TBI)is crucial.The predisposition ... BACKGROUND The prognosis of acute mesenteric ischemia(AMI)caused by superior mesenteric venous thrombosis(SMVT)remains undetermined and early detection of transmural bowel infarction(TBI)is crucial.The predisposition to develop TBI is of clinical concern,which can lead to fatal sepsis with hemodynamic instability and multi-organ failure.Early resection of necrotic bowel could improve the prognosis of AMI,however,accurate prediction of TBI remains a challenge for clinicians.When determining the eligibility for explorative laparotomy,the underlying risk factors for bowel infarction should be fully evaluated.AIM To develop and externally validate a nomogram for prediction of TBI in patients with acute SMVT.METHODS Consecutive data from 207 acute SMVT patients at the Wuhan Tongji Hospital and 89 patients at the Guangzhou Nanfang Hospital between July 2005 and December 2018 were included in this study.They were grouped as training and external validation cohort.The 207 cases(training cohort)from Tongji Hospital were divided into TBI and reversible intestinal ischemia groups based on the final therapeutic outcomes.Univariate and multivariate logistic regression analyses were conducted to identify independent risk factors for TBI using the training data,and a nomogram was subsequently developed.The performance of the nomogram was evaluated with respect to discrimination,calibration,and clinical usefulness in the training and external validation cohort.RESULTS Univariate and multivariate logistic regression analyses identified the following independent prognostic factors associated with TBI in the training cohort:The decreased bowel wall enhancement(OR=6.37,P<0.001),rebound tenderness(OR=7.14,P<0.001),serum lactate levels>2 mmol/L(OR=3.14,P=0.009)and previous history of deep venous thrombosis(OR=6.37,P<0.001).Incorporating these four factors,the nomogram achieved good calibration in the training set[area under the receiver operator characteristic curve(AUC)0.860;95%CI:0.771-0.925]and the external validation set(AUC 0.851 展开更多
关键词 Superior mesenteric venous thrombosis Acute mesenteric ischemia Transmural bowel infarction Reversible intestinal ischemia PREDICTORS NOMOGRAM
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急性下肢缺血再灌注损伤机制的研究进展 认领
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作者 谷岩 何菊 +1 位作者 侯骊坤 刘辉 《齐齐哈尔医学院学报》 2020年第12期1521-1522,共2页
肢体缺血再灌注的发生可以影响急性机械性创伤患者进行血管外科手术的预后,因此一直是临床上的研究热点,特别是针对病理改变机制的研究。本文此次将目前对于急性下肢缺血再灌注损伤的机制总结并综述如下。
关键词 缺血 缺血再灌注 氧自由基 研究进展
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文章速递还原型谷胱甘肽对大鼠心肌缺血-再灌注后脑组织损伤的保护作用 认领
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作者 孙要军 孙博健 +3 位作者 张艳霞 弓昌平 李圆 孙丙毅 《中国药物与临床》 CAS 2020年第23期3905-3907,共3页
心肌梗死时及时的再灌注是抢救梗死心肌唯一有效的途径,可以使频临坏死的危险区心肌细胞得到挽救。但是,缺血心肌的再灌注还会引发心肌更为严重的损伤,增大梗死面积,称之为心肌缺血再灌注损伤(myocardial ischemia-reperfusion injury,M... 心肌梗死时及时的再灌注是抢救梗死心肌唯一有效的途径,可以使频临坏死的危险区心肌细胞得到挽救。但是,缺血心肌的再灌注还会引发心肌更为严重的损伤,增大梗死面积,称之为心肌缺血再灌注损伤(myocardial ischemia-reperfusion injury,MRI)。研究证实,再灌注期活性氧(reactive oxygen species,ROS)的进一步形成是造成包括心脏本身在内,机体各脏器氧化损伤的主要原因之一[1]。甲醛是日常家装后最常见的室内空气污染物,也是室内氧化剂的重要来源,吸入甲醛会导致组织器官的氧化损伤[2]。本研究将从检测脑组织超氧化物歧化酶(superoxide dismutase,SOD)与谷胱甘肽过氧物酶(glutathione peroxidase,GSH-Px)活性以及丙二醛(malondialdehyde,MDA)含量的变化来反映心肌缺血再灌注对脑组织产生的损伤。同时模拟心肌梗死患者生活环境中甲醛吸入对其损伤产生的影响,并使用还原型谷胱甘肽(GSH)干预期望对脑组织具有一定的保护作用。 展开更多
关键词 还原型谷胱甘肽 心肌缺血再灌注 脑组织损伤 梗死心肌 超氧化物歧化酶 ischemia 心肌细胞 心肌梗死
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文章速递Traditional Chinese Medicines alleviated myocardial ischemia by regulating Qi and promoting blood circulation 认领
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作者 Wang Chen Wang Xiaoreng +5 位作者 Tao Tianqi Song Dandan Wang Jianli Wang You Liu Xiuhua Wu Xudong 《中医杂志:英文版》 SCIE CAS CSCD 2020年第6期974-982,共9页
OBJECTIVE:To investigate the efficacy of Chinese medicines on Qi stagnation and blood stasis in rats with myocardial ischemia.METHODS:Fifty male Wistar rats were randomly divided into five groups(n=10)as follows:(a)sh... OBJECTIVE:To investigate the efficacy of Chinese medicines on Qi stagnation and blood stasis in rats with myocardial ischemia.METHODS:Fifty male Wistar rats were randomly divided into five groups(n=10)as follows:(a)sham operation(Sham),(b)myocardial ischemia(Model),(c)treatment that regulates Qi(Qi),(d)treatment that promotes blood circulation(Blood),(e)treatment that both regulates Qi and promotes blood circulation(QB).The rat model was established via activities restriction for 6 h followed by tail clamp stimulation for 5 mins every day for 7 d and occlusion left coronary anterior descending artery.Afterwards rats were treated with medicines that regulate Qi and/or promote blood circulation via gavage for 14 d.Behavioral parameters were evaluated using open field and elevated plus-maze tests.The tongue color and sublingual vein were visually examined.Blood flow perfusion of tongue and auricle were detected using PIMⅡ.The mesenteric microcirculation was examined via capillaroscopy,and hemodynamics was assessed using a polygraph system.Serum homocysteine(Hcy),creatine kinase isoenzyme(CKMB)levels and endothelin-1(ET-1)were measured.Hematoxylin and eosin staining and transmission electron microscopy were employed to detect the myocardial morphology and ultrastructure,respectively.RESULTS:Compared with findings in Sham group,rats in model group had coarse hair,dark mucosa of the lips and claw,low activity,and increased anxiety.Compared with findings in Model group,rats in the three treatment groups exhibited a lighter tongue color without an extended and varicose sublingual vein.There were significant increases of auricle blood flow perfusion in the Qi group and tongue bottom blood flow perfusion in the QB group.Compared with findings in Model rats,rats in Blood group exhibited improved mesenteric microcirculation associated with increased mesenteric blood flow and a larger arteriole diameter.Moreover,compared with findings in Model rats,Qi and QB rats exhibited increased left ventricular±dp/dtmax,decreased serum CKMB,Hcy,ET-1 levels,and reduced myocardial ultrastructural damage.CONCLUSION:Myocardial ischemia damage was suppressed by Traditional Chinese Medicines that regulate Qi and promote blood circulation. 展开更多
关键词 Myocardial ischemia Homocysteine Endothelin-1 Creatine kinase Isoenzymes Qi-stagnation and blood-stasis Regulating Qi and promoting blood circulation
文章速递纯化自体CD34^+细胞移植治疗炎性肢体重度缺血的远期疗效 认领
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作者 蒋小浪 方圆 +13 位作者 潘天岳 刘浩 魏征 顾史洋 陈斌 蒋俊豪 石贽 郭大乔 徐欣 杨狂 史振宇 刘澎 董智慧 符伟国 《中华普通外科杂志》 CSCD 北大核心 2020年第12期961-965,共5页
目的探讨纯化自体CD34^+细胞移植(autotransplantation of purified CD34^+cells,ATPCC)治疗炎性肢体重度缺血(angitis-induced critical limb ischemia,AICLI)的远期疗效。方法回顾性分析2009年5月至2016年6月采用ATPCC治疗不具备血管... 目的探讨纯化自体CD34^+细胞移植(autotransplantation of purified CD34^+cells,ATPCC)治疗炎性肢体重度缺血(angitis-induced critical limb ischemia,AICLI)的远期疗效。方法回顾性分析2009年5月至2016年6月采用ATPCC治疗不具备血管重建条件的43例AICLI的患者资料。分选获得外周血CD34^+细胞肌肉注射。观察无大截肢生存率(major-amputation-free survival rate,MAFS)作为主要终点事件,次要终点事件包括最长无痛步行时间(peak pain-free walking time,PPFWT),Wong-Baker FACES疼痛评分(Wong-Baker FACES pain rating scale score,WFPRSS)和劳动能力恢复率。其他观察指标包括踝肱指数(ankle-brachial index,ABl)、趾肱指数(toe-brachial index,TBI)和经皮氧分压(transcutaneous partial oxygen pressure,TcPO,)等。结果﹑随访36~120个月,中位随访时间80.8个月。36个月的MAFS为90.69%。术后6个月,ABl由术前的0.52±0.24上升至0.69±0.18(P<0.001);TBl由术前的0.11±0.16上升至0.34±0.15(P<0.001);TcPO。由术前的(22.6±9.7)mmHg(1 mmHg=0.133 kPa)提高至(43.0±10.3)mmHg(P<0.001)。术后第3年,PPFWT由术前的(4.5±6.1)min延长至(9.0±6.3)min(P<0.001);WFPRSS由术前的7.7±1.5下降至1.0±1.1(P<0.001)。67.4%(29/43)的患者恢复了劳动能力。治疗过程中未发生严重并发症。SF-36v2量表评分在移植3年后显著提高。结论ATPCC治疗AICLI安全有效,显著改善缺血,挽救肢体,提高生活质量,恢复劳动能力,且疗效较为持久。 展开更多
关键词 血管炎 缺血 细胞移植 CD34^+
Effects of cluster needling of scalp acupuncture on neurofilament protein 200 and signal transducer and activator of transcription 3 in rats with acute cerebral ischemia 认领
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作者 Xue Fang Jinxia Ni +4 位作者 Buyi Su Huiyan An Miaomiao Li Jie Wang Xiaona Wu 《中医科学杂志(英文)》 2020年第1期82-86,共5页
Objective:Cluster needling at scalp acupoints has showed satisfying effects with acute cerebral ischemia in clinic whereas the mechanisms are not yet clear completely.This study investigated the influence of cluster n... Objective:Cluster needling at scalp acupoints has showed satisfying effects with acute cerebral ischemia in clinic whereas the mechanisms are not yet clear completely.This study investigated the influence of cluster needling at scalp acupoints on neurological function,as well as on neurofilament protein 200(NF200)and signal transducer and activator of transcription 3(STAT3)expression,in rats with acute cerebral ischemia.Methods:Fifty-four Sprague-Dawley rats were randomly assigned in equal numbers to the false operation(group F),model(group M),or cluster needling scalp acupuncture(group C)groups.Each group was divided into three subgroups,of six rats each,by acupuncture treatment time(24 h,7 days,and 14 days).The rat local cerebral ischemia model was prepared using a modified suture occlusion method.Group C rats were treated by cluster needling scalp acupuncture,while groups F and M did not receive acupuncture treatment.Neurological effects were evaluated using the Longa score.NF200 and STAT3 expression were measured by western blotting.Results:At 24 h,there were no statistical difference between group C and group M in nerve function(P>.05).On days 7 and 14,nerve function scores in group C were significantly lower than that in group M(respectively were P<.05 and P<.01).In addition,on days 14,expression of NF200 was significantly higher in group C compared with group M(P<.05).Compared with group M,STAT3 expression was also higher in group C on days 7 and 14,although these differences were not statistically significant(both P>.05).Conclusion:Cluster needling scalp acupuncture were efficient in improving nerve function scores in rats with cerebral ischemia,and promoting the recovery of motor function.These improvements were associated with increases in NF200 and STAT3 expression. 展开更多
关键词 Cluster needling scalp acupuncture Acute cerebral ischemia NF200 STAT3 Suture occlusion method Rat model
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应重视培养急腹症诊断中急性肠缺血的病理生理与CT影像相关联的系统性思维模式 认领
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作者 朱明杰 王自强 《中国普外基础与临床杂志》 CAS 2020年第12期1473-1479,共7页
急腹症时多种病理机制均可导致急性肠道缺血坏死(acute intestinal ischemia or acute colic ischem ia),包括急性肠系膜缺血性疾病(acute mesenteric ischemia,AMI,含动脉栓塞、静脉血检等)、绞窄性肠梗阻(strangulated bowel obstruct... 急腹症时多种病理机制均可导致急性肠道缺血坏死(acute intestinal ischemia or acute colic ischem ia),包括急性肠系膜缺血性疾病(acute mesenteric ischemia,AMI,含动脉栓塞、静脉血检等)、绞窄性肠梗阻(strangulated bowel obstruction,SBO)、血管炎性(vasculitis)疾病、感染性肠道炎症等疾病[1]。肠道缺血坏死导致急性弥漫性腹膜炎、感染性休克、大段肠道切除甚至短肠综合征等严重病理生理后果,是急腹症中最紧急、最严重的情况之一,也是最易延误诊断的情况。 展开更多
关键词 绞窄性肠梗阻 动脉栓塞 肠道炎症 急腹症诊断 病理生理 感染性休克 ischemia 短肠综合征
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