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MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression 预览
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作者 Bridget Martinez Philip V.Peplow 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期606-619,共14页
Multiple sclerosis is a chronic autoimmune disease of the central nervous system.It is the main cause of non-traumatic neurological disability in young adults.Multiple sclerosis mostly affects people aged 20–50 years... Multiple sclerosis is a chronic autoimmune disease of the central nervous system.It is the main cause of non-traumatic neurological disability in young adults.Multiple sclerosis mostly affects people aged 20–50 years;however,it can occur in young children and much older adults.Factors identified in the distribution of MS include age,gender,genetics,environment,and ethnic background.Multiple sclerosis is usually associated with progressive degrees of disability.The disease involves demyelination of axons of the central nervous system and causes brain and spinal cord neuronal loss and atrophy.Diagnosing multiple sclerosis is based on a patient’s medical history including symptoms,physical examination,and various tests such as magnetic resonance imaging,cerebrospinal fluid and blood tests,and electrophysiology.The disease course of multiple sclerosis is not well correlated with the biomarkers presently used in clinical practice.Blood-derived biomarkers that can detect and distinguish the different phenotypes in multiple sclerosis may be advantageous in personalized treatment with disease-modifying drugs and to predict response to treatment.The studies reviewed have shown that the expression levels of a large number of miRNAs in peripheral blood,serum,exosomes isolated from serum,and cerebrospinal fluid are altered in multiple sclerosis and can distinguish the disease phenotypes from each other.Further studies are warranted to independently validate these findings so that individual or pairs of miRNAs in serum or cerebrospinal fluid can be used as potential diagnostic markers for adult and pediatric multiple sclerosis and for monitoring disease progression and response to therapy. 展开更多
关键词 clinically isolated syndrome CSF disease PROGRESSION EXOSOMES humans microRNA multiple SCLEROSIS PERIPHERAL blood PHENOTYPES serum
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人子宫移植后临床妊娠并成功分娩活产儿案例分析 预览
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作者 欧阳振波 魏世远 +4 位作者 盘翠丽 高天旸 钟碧婷 许姣姣 吴嘉雯 《中华妇幼临床医学杂志(电子版)》 CAS 2020年第1期93-99,共7页
目的探讨文献报道的人子宫移植后,在受者移植子宫内临床妊娠,并成功分娩活产儿的可行性,以及母儿结局分析。方法选择受者接受子宫移植后,在移植子宫内临床妊娠,并成功分娩活产儿的文献为研究对象。以“uterine transplantation”或“ute... 目的探讨文献报道的人子宫移植后,在受者移植子宫内临床妊娠,并成功分娩活产儿的可行性,以及母儿结局分析。方法选择受者接受子宫移植后,在移植子宫内临床妊娠,并成功分娩活产儿的文献为研究对象。以“uterine transplantation”或“uterus transplantation”为英文检索词,“子宫移植”和“活产”为中文检索词,检索PubMed数据库、万方数据知识服务平台及中国知网数据库中,关于人子宫移植后,在移植子宫内临床妊娠,并成功分娩活产儿的文献,检索时间设定为各文献库建库至2018年12月。分析文献报道的接受子宫移植受者的临床病例资料,包括一般临床资料,孕期并发症、分娩及产后情况,母儿结局,以及分娩的活产新生儿情况等。结果①自检索文献中筛选符合本研究纳入与排除标准的文献共计15篇,均为国外文献。涉及子宫移植后在移植子宫内临床妊娠,并成功分娩活产儿的受者共计12例,分娩活产儿共计12例。②受者一般临床资料:66.7%(8/12)受者在瑞典接受子宫移植,并成功分娩活产儿。90.9%(10/11)受者接受子宫移植的原因为苗勒管发育不全(MRKH)综合征。58.3%(7/12)受者接受子宫移植的子宫供体,来源于与其有血缘关系的供者。91.7%(11/12)受者采取活体供体子宫移植,1例为死亡供体子宫移植。本组12例子宫移植受者的受孕方式,均为体外受精-胚胎移植(IVF-ET),并且均为单胚胎移植。在其孕期,多采用免疫抑制治疗预防移植物抗宿主反应,并采用宫颈活组织检查进行免疫监测。③受者孕期、分娩及产后情况:孕期主要的产科并发症为妊娠期高血压疾病及妊娠期肝内胆汁淤积症(ICP)。其中,10例受者分娩时的平均孕龄为34+孕周;12例受者采取剖宫产术分娩,并且剖宫产术中及产后24 h无大出血、死亡等严重并发症发生,75.0%(9/12)继续保留子宫,其中1例再次成功妊娠。④分娩的活产新� 展开更多
关键词 人类 婴儿安全出生 妊娠 移植受者 活体供者 移植物抗宿主反应 单胚胎移植 子宫移植
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Potential Impact of Space Environments on Developmental and Maturational Programs Which Evolved to Meet the Boundary Conditions of Earth: Will Maturing Humans Be Able to Establish a Functional Biologic System Set Point under Non-Earth Conditions? 预览
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作者 David A. Hart 《生物医学工程(英文)》 2019年第12期500-513,共14页
Mammalian development and maturation, particularly processes for humans have evolved in the context of the boundary conditions of Earth (i.e. 1 g gravity, geomagnetic field, background radiation) to yield functional i... Mammalian development and maturation, particularly processes for humans have evolved in the context of the boundary conditions of Earth (i.e. 1 g gravity, geomagnetic field, background radiation) to yield functional individuals, although the process is not perfect and “errors” do occur. With the advent of spaceflight to low Earth orbit (the International Space Station), humans are now exposed to microgravity and increased exposure to radiation. However, thus far, only adult humans have served as astronauts, but this will likely change with plans to explore deep space and colonize planets. Thus, conception, fetal development, post-birth maturation, puberty and skeletal maturity will occur in the context of boundary conditions that did not shape human evolution and influence physiological and biomechanical systems designed to function within the Earth’s boundary conditions. Thus, processes utilizing the 1 g environment (i.e. walking upright) and the geomagnetic field (i.e. the electrical/biomagnetic basis of neural interactions) will have to adapt to new boundary conditions, providing opportunity for additional errors or alterations in processing during development which could impact functional outcomes at multiple levels. This review/perspective will discuss some of these issues and attempt to provide direction for addressing the potential issues to be encountered. 展开更多
关键词 Development MATURATION Humans MICROGRAVITY GEOMAGNETIC Influences Space Environments
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The <i>in Vivo</i>Antioxidant Effects of (&minus;)-Epigallocatechin-3-Gallate Consumption in Healthy Postmenopausal Women Measured by Urinary Excretion of Secondary Lipid Peroxidation Products 预览
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作者 Chelsey Fiecke Mindy Kurzer +1 位作者 Chi Chen A. Saari Csallany 《食品与营养科学(英文)》 2019年第1期15-27,共13页
The present study was carried out to determine whether the consumption of epigallocatechin (EGCG), the major bioactive green tea catechin, exerts a positive effect on lowering in vivo lipid peroxidation, a measure of ... The present study was carried out to determine whether the consumption of epigallocatechin (EGCG), the major bioactive green tea catechin, exerts a positive effect on lowering in vivo lipid peroxidation, a measure of oxidative stress, in healthy postmenopausal women. Urinary excretion of secondary lipid peroxidation products, a measure of in vivo lipid peroxidation, was determined in 40 participants randomly assigned to consume a green tea catechin extract (843.0 ± 44.0 mg EGCG/d) or placebo capsules for 12 months. Urine samples were analyzed for individual polar and nonpolar lipophilic aldehydes and related carbonyl compounds by high-performance liquid chromatography (HPLC) at the beginning and at the end of the 12-month intervention period. Results show that two nonpolar aldehydes, nonanal and decatrienal, were both 48% lower (p in vivo antioxidant activity exists with long-term EGCG consumption, which could slightly limit oxidative damage associated with lipid peroxidation and the onset and progression of chronic diseases. 展开更多
关键词 Antioxidants Epigallocatechin-3-Gallate Green Tea Humans Lipid PEROXIDATION Urinary EXCRETION
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浅析人工智能与人类关系的探究 预览
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作者 陈予灿 《数码设计》 2019年第7期115-116,共2页
随着计算机技术与信息技术的发展,人工智能在人类生活中担任着重要的角色,那么,人工智能与人类之间的关系将会如何发展,会不会产生矛盾?本文从人工智能的各个方面着手,介绍了人工智能,人工智能的普及及应用以及与人类的关系。
关键词 人工智能 人类 关系
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Differential effects of atrial and brain natriuretic peptides on human pulmonary artery: An in vitro study 预览
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作者 Azar Hussain Robert T Bennett +5 位作者 Zaheer Tahir Emmanuel Isaac Mubarak A Chaudhry Syed S Qadri Mahmoud Loubani Alyn H Morice 《世界心脏病学杂志:英文版(电子版)》 2019年第10期236-243,共8页
BACKGROUND The prevalence of cardiovascular diseases,especially heart failure,continues to rise worldwide.In heart failure,increasing levels of circulating atrial natriuretic peptide(ANP)and brain natriuretic peptide(... BACKGROUND The prevalence of cardiovascular diseases,especially heart failure,continues to rise worldwide.In heart failure,increasing levels of circulating atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP)are associated with a worsening of heart failure and a poor prognosis.AIM To test whether a high concentration of BNP would inhibit relaxation to ANP.METHODS Pulmonary arteries were dissected from disease-free areas of lung resection,as well as pulmonary artery rings of internal diameter 2.5–3.5 mm and 2 mm long,were prepared.Pulmonary artery rings were mounted in a multiwire myograph,and a basal tension of 1.61gf was applied.After equilibration for 60 min,rings were pre-constricted with 11.21μmol/L PGF2α(EC80),and concentration response curves were constructed to vasodilators by cumulative addition to the myograph chambers.RESULTS Although both ANP and BNP were found to vasodilate the pulmonary vessels,ANP is more potent than BNP.pEC50 of ANP and BNP were 8.96±0.21 and 7.54±0.18,respectively,and the maximum efficacy(Emax)for ANP and BNP was-2.03 gf and-0.24 gf,respectively.After addition of BNP,the Emax of ANP reduced from-0.96gf to-0.675gf(P=0.28).CONCLUSION BNP could be acting as a partial agonist in small human pulmonary arteries,and inhibits relaxation to ANP.Elevated levels of circulating BNP could be responsible for the worsening of decompensated heart failure.This finding could also explain the disappointing results seen in clinical trials of ANP and BNP analogues for the treatment of heart failure. 展开更多
关键词 HEART FAILURE ATRIAL NATRIURETIC PEPTIDE Brain NATRIURETIC PEPTIDE In-vitro Humans
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急性炎性疾病患者乳酸林格氏液液体动力学 预览
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作者 叶晓敏 易声华 +4 位作者 朱烨柯 单跃 腾尹彤 滕文彬 李玉红 《中国临床药理学与治疗学》 CAS CSCD 2019年第4期424-432,共9页
目的:探索炎性疾病患者的乳酸林格氏液(Ringer's lactate,RL)液体动力学特征以及炎性生物标记物是否可以作为协变量影响RL分布和排泄。方法:本研究为前瞻性队列研究。选择40例美国麻醉医师分级(ASA)Ⅰ-Ⅱ级,腹腔镜下择期胆囊切除术... 目的:探索炎性疾病患者的乳酸林格氏液(Ringer's lactate,RL)液体动力学特征以及炎性生物标记物是否可以作为协变量影响RL分布和排泄。方法:本研究为前瞻性队列研究。选择40例美国麻醉医师分级(ASA)Ⅰ-Ⅱ级,腹腔镜下择期胆囊切除术(胆囊炎组, n =20)或者腹腔镜下急诊阑尾切除术(阑尾炎组, n=20)。所有患者麻醉诱导前开始输注RL,按15 mL/kg,35 min内输毕。采用酶联免疫(enzyme-linked immunosorbent assay,ELISA)方法测定血浆炎症(TNF-α,IL-10和CRP)或者内皮损伤生物标记物(syndecan-1,SDC-1);利用血红蛋白(Hb)稀释-时间曲线和尿量,使用Phoenix软件,采用非线性混合效应模型分析计算RL液体动力学参数和协变量的影响。结果:与胆囊炎组相比,阑尾炎组RL从组织间隙到血浆的转运速率常数( k 21 )显著降低(14×10^-3 min^-1 versus 35×10^-3 min^-1;P = 0.012 )。阑尾炎组C反应蛋白(CRP)升高[中位数38.1( 1.8 - 143.6 )μg/mL versus 1.3( 0.1 - 159.0 )μg/mL;P < 0.001 ];与清醒状态相比,麻醉期间(输液开始后30~45 min),液体从中央室中到外周室的转运速率常数( k 12 )显著增加(57×10^-3 min^-1 versus 32×10^-3 min^-1;P < 0.01 )。清除速率常数( k 10 )降低90%( 0.6 ×10 -3 min^-1 versus 5.3 ×10^-3 min^-1;P < 0.001 )。无论在清醒状态还是麻醉状态下低血压均能降低液体清除;炎症或者内膜损伤的生物标记物不能作为显著影响RL液体动力学参数的协变量。结论:阑尾炎或者胆囊炎患者术前输入液体后“炎症反应的生物标记物”不是RL的液体动力学的协变量,但是两组患者中,全身麻醉期间输入液体的清除率下降。 展开更多
关键词 晶体液 乳酸林格氏液 人类 炎症 液体动力学
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Human Hydatidosis: A Negliged Zoonosis and Underdeclared at the University Hospital Center of Tlemcen, Algeria: 16 Years of Registration from 2003 to 2018 预览
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作者 Samira Benbekhti Abdrebbi Kaouel Meguenni 《健康科学:英文版》 2019年第6期385-390,共6页
Hydatid disease is considered as an important emerging neglected disease worldwide.Cystic echinococcosis is a neglected disease of public health significance in many low and middle-income countries.The objective of ou... Hydatid disease is considered as an important emerging neglected disease worldwide.Cystic echinococcosis is a neglected disease of public health significance in many low and middle-income countries.The objective of our study was to determine the epidemiological profile of human hydatidosis in Tlemcen.A prospective study was conducted at University Hospital Center(UHC)of Tlemcen,from 2003 to 2018 from the declaration of notifiable diseases.Data entry and analysis was done using Epi-info software 6.One hundred and fifty-eight(158)patients were declared during 16 years of registartion at the UHC of Tlemcen.Ninety three point zero three percent(93.03%)of the reports of cases were received from the surgical services and 6 cases from the pneumology department.A slight female predominance was noted with sex-ratio(Females/Males):1.15.More than half of the patients were subjects over 40 years old.Three cases were noted in children.The average age was 42.38±17.14 years.The liver was the most frequent organ involved in our study followed by pulmonary localization.Fifty one point eight seven(51.87%)of cases were from rural areas and 46.2%from urban areas.Human hydatidosis remains an under-reported and neglected disease in Tlemcen whose fight is essentially based on preventive measures and requires multisectoral collaboration. 展开更多
关键词 Humans HYDATIDOSIS CYSTIC ECHINOCOCCOSIS epidemiology DECLARATION prevention Tlemcen
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Epidemiology of hepatitis E in South-East Europe in the"One Health"concept 预览
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作者 Anna Mrzljak Petra Dinjar-Kujundzic +5 位作者 Lorena Jemersic Jelena Prpic Ljubo Barbic Vladimir Savic Vladimir Stevanovic Tatjana Vilibic-Cavlek 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第25期3168-3182,共15页
The significance of hepatitis E virus(HEV)as an important public health problem is rising.Until a decade ago,cases of HEV infection in Eur-ope were mainly confined to returning travelers,but nowadays,hepatitis E repre... The significance of hepatitis E virus(HEV)as an important public health problem is rising.Until a decade ago,cases of HEV infection in Eur-ope were mainly confined to returning travelers,but nowadays,hepatitis E represents an emerging zoonotic infection in many European countries.The aim of this manuscript is to perform a systematic review of the published literature on hepatitis E distribution in humans,animals and environmental samples("One Health"concept)in the South-Eastern European countries.Comparison of the available data showed that the anti-HEV seroprevalence in the South-Eastern Europe varies greatly,depending on the population studied,geographical area and methods used.The IgG seroprevalence rates in different population groups were found to be 1.1%-24.5%in Croatia,up to 20.9%in Bulgaria,5.9-%17.1%in Romania,15%in Serbia,up to 9.7%in Greece and 2%-9.7%in Albania.Among possible risk factors,older age was the most significant predictor for HEV seropositivity in most studies.Higher seroprevalence rates were found in animals.HEV IgG antibodies in domestic pigs were detected in 20%-54.5%,29.2%-50%,38.94%-50%and 31.1%-91.7%in Serbia,Bulgaria,Romania and Croatia,respectively.In wild boars seroprevalence rates were up to 10.3%,30.3%and 31.1%in Romania,Slovenia and Croatia,respectively.A high HEV RNA prevalence in wild boars in some countries(Croatia and Romania)indicated that wild boars may have a key role in the HEV epidemiology.There are very few data on HEV prevalence in environmental samples.HEV RNA was detected in 3.3%and 16.7%surface waters in Slovenia and Serbia,respectively.There is no evidence of HEV RNA in sewage systems in this region.The available data on genetic characterization show that human,animal and environmental HEV strains mainly belong to the genotype 3. 展开更多
关键词 Hepatitis E virus "One-Health" Humans Animals Environment South-East EUROPE
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MicroRNAs as biomarkers of diabetic retinopathy and disease progression 预览
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作者 Bridget Martinez Philip V. Peplow 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1858-1869,共12页
Diabetes mellitus, together with its complications, has been increasing in prevalence worldwide. Its complications include cardiovascular disease(e.g., myocardial infarction, stroke), neuropathy, nephropathy, and eye ... Diabetes mellitus, together with its complications, has been increasing in prevalence worldwide. Its complications include cardiovascular disease(e.g., myocardial infarction, stroke), neuropathy, nephropathy, and eye complications(e.g., glaucoma, cataracts, retinopathy, and macular edema). In patients with either type 1 or type 2 diabetes mellitus, diabetic retinopathy is the leading cause of visual impairment or blindness. It is characterized by progressive changes in the retinal microvasculature. The progression from nonproliferative diabetic retinopathy to a more advanced stage of moderate to severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy occurs very quickly after diagnosis of mild nonproliferative diabetic retinopathy. The etiology of diabetic retinopathy is unclear, and present treatments have limited effectiveness. Currently diabetic retinopathy can only be diagnosed by a trained specialist, which reduces the population that can be examined. A screening biomarker of diabetic retinopathy with high sensitivity and specificity would aid considerably in identifying those individuals in need of clinical assessment and treatment. The majority of the studies reviewed identified specific microRNAs in blood serum/plasma able to distinguish diabetic patients with retinopathy from those without retinopathy and for the progresion of the disease from nonproliferative diabetic retinopathy to proliferative diabetic retinopathy. In addition,certain microRNAs in vitreous humor were dysregulated in proliferative diabetic retinopathy compared to controls. A very high percentage of patients with diabetic retinopathy develop Alzheimer’s disease. Thus, identifying diabetic retinopathy by measurement of suitable biomarkers would also enable better screening and treatment of those individuals at risk of Alzheimer’s disease. 展开更多
关键词 DIABETES RETINOPATHY diagnosis disease PROGRESSION MICRORNAS biomarkers blood serum/ plasma VITREOUS HUMOR humans
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笛卡尔的“动物是机器”理论探究 预览
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作者 张哲 舒红跃 《南华大学学报:社会科学版》 2019年第5期26-30,共5页
笛卡尔早期把动物比作自动机,提出了“动物是机器”的观点,由此从动物界扩展到了整个物质世界,为其机械唯物论思想提供了理论支持,并通过身心二元论的视角强调人与动物的根本区别在于是否拥有理性的灵魂。在后期,笛卡尔用身心交感说消... 笛卡尔早期把动物比作自动机,提出了“动物是机器”的观点,由此从动物界扩展到了整个物质世界,为其机械唯物论思想提供了理论支持,并通过身心二元论的视角强调人与动物的根本区别在于是否拥有理性的灵魂。在后期,笛卡尔用身心交感说消弭其早年在灵魂与肉体之间划下的鸿沟。笛卡尔的动物观是在充满着矛盾和自我修正的过程中发展的,虽然有人提出质疑,但它仍对当时的社会思潮及后世哲学起到了积极的启发和引导作用。 展开更多
关键词 勒内·笛卡尔 动物 机器 身心
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Serological Survey of Zika Virus in Humans and Animals in Dejiang Prefecture,Guizhou Province,China 预览
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作者 LI Fan ZHOU Jing Zhu +12 位作者 ZHOU Lei FU Shi Hong TIAN Zhen Zao WANG Qi SHAO Nan LI Dan HE Ying LEI Wen Wen TANG Guang Peng LIANG Guo Dong WANG Ding Ming ZHANG Yan Ping WANG Huan Yu 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第12期875-880,共6页
Objective The current outbreak of Zika virus(ZIKV)poses a severe threat to human health.Two ZIKV strains were isolated from mosquitoes collected from the Dejiang prefecture in China in 2016,which was the first isolati... Objective The current outbreak of Zika virus(ZIKV)poses a severe threat to human health.Two ZIKV strains were isolated from mosquitoes collected from the Dejiang prefecture in China in 2016,which was the first isolation of ZIKV in nature in China.Methods In this study,serum samples were collected from 366 healthy individuals and 104 animals from Dejiang prefecture in 2017,and the plaque reduction neutralization test(PRNT)was used to evaluate the seroprevalence of ZIKV.Results None of the 366 residents from whom the samples were collected were seropositive for ZIKV.None of the 11 pigs from whom the samples were collected were seropositive for ZIKV,while 1 of 63(1.59%)chickens and 2 of 30(6.67%)sheep were seropositive for ZIKV.Conclusions The extremely low seropositivity rate of ZIKV antibodies in animals in the Dejiang prefecture,Guizhou province in this study indicates that ZIKV can infect animals;however,there is a low risk of ZIKV circulating in the local population. 展开更多
关键词 Zika Virus Serological survey Humans ANIMALS China Plague reduction neutralization test
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MicroRNAs as diagnostic and therapeutic tools for Alzheimer's disease: advances and limitations 预览
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作者 Bridget Martinez Philip V. Peplow 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第2期242-255,共14页
Alzheimer's disease (AD) is the most common age-related, progressive neurodegenerative disease. It is characterized by memory loss and cognitive decline and responsible for most cases of dementia in the elderly. L... Alzheimer's disease (AD) is the most common age-related, progressive neurodegenerative disease. It is characterized by memory loss and cognitive decline and responsible for most cases of dementia in the elderly. Late-onset or sporadic AD accounts for > 95% of cases, with age at onset > 65 years. Currently there are no drugs or other therapeutic agents available to prevent or delay the progression of AD. The cellular and molecular changes occurring in the brains of individuals with AD include accumulation of β-amyloid peptide and hyperphosphorylated tau protein, decrease of acetylcholine neurotransmitter, inflammation, and oxidative stress. Aggregation of β-amyloid peptide in extracellular plaques and the hyperphosphorylated tau protein in intracellular neurofibrillary tangles are characteristic of AD. A major challenge is identifying molecular biomarkers of the early-stage AD in patients as most studies have been performed with blood or brain tissue samples (postmortem) at late-stage AD. Subjects with mild cognitive impairment almost always have the neuropathologic features of AD with about 50% of mild cognitive impairment patients progressing to AD. They could provide important information about AD pathomechanism and potentially also highlight minimally or noninvasive, easy-to-access biomarkers. MicroRNAs are dysregulated in AD, and may facilitate the early detection of the disease and potentially the continual monitoring of disease progression and allow therapeutic interventions to be evaluated. Four recent reviews have been published of microRNAs in AD, each of which identified areas of weakness or limitations in the reported studies. Importantly, studies in the last three years have shown considerable progress in overcoming some of these limitations and identifying specific microRNAs as biomarkers for AD and mild cognitive impairment. Further large-scale human studies are warranted with less disparity in the study populations, and using an appropriate method to validate the findings. 展开更多
关键词 Alzheimer's disease mild cognitive IMPAIRMENT MICRORNAS biomarkers blood brain tissue CEREBROSPINAL fluid humans animal models
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RAINBOW WEAVERS
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作者 Yuan Yuan 《北京周报:英文版》 2019年第20期16-17,共2页
In the language of the Derung ethnic group in China, Naze Naze Brao means "weaving slowly." This tradition and technique has been handed down for generations by the women of the ethnic group who weave blanke... In the language of the Derung ethnic group in China, Naze Naze Brao means "weaving slowly." This tradition and technique has been handed down for generations by the women of the ethnic group who weave blankets on looms known to be the earliest ones used by humans. 展开更多
关键词 DERUNG ETHNIC GROUP WOMEN of the ETHNIC GROUP ONES used by humans
Physiological and Molecular Characterization of <i>Malassezia pachydermatis</i>Reveals No Differences between Canines and Their Owners 预览
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作者 Juan Camilo Galvis Marín Fernando Borda Rojas Andrés Julián Gutiérrez Escobar 《兽医学(英文)》 2018年第7期87-105,共19页
Introduction: The genus Malassezia comprises 17 species of commensal and pathogenic yeasts of homeotherms animal skin. The most common species are M. furfur, M. globosa, and M. sympodialis in humans and M. pachydermat... Introduction: The genus Malassezia comprises 17 species of commensal and pathogenic yeasts of homeotherms animal skin. The most common species are M. furfur, M. globosa, and M. sympodialis in humans and M. pachydermatis in animals. However, some publications have reported potentially serious human infections by M. pachydermatis in individuals with risk factors and the isolation of human species from domestic animals. Given the scarcity of information about their capacity for transmission between hosts and zoonotic potential, the aim of the present study was to physiologically and molecularly characterize Malassezia spp. isolates obtained from canines and their human owners. Materials and Methods: An experimental study was conducted at the Veterinary Clinic of Universidad de Ciencias Aplicadas y Ambientales of Bogotá (Colombia) from July 2015 to December 2016. Phenotypic identification and molecular characterization via the amplification of the 5.8S rDNA- ITS2 and 26S rDNA gene regions, nucleic acid sequencing, and phylogenetic analyses were performed on isolates originating from canines with otitis externa and from the skin of healthy owners compatible with Malassezia spp. Results: Eighty samples were cultured, of which 32 (40%) were suggestive of Malassezia spp. A total of 29 out of 46 (63%) isolates in canines and 3 out of 34 (9%) isolates in humans corresponded entirely with M. pachydermatis. Isolates from the canines and their owners presented similar behavior in biochemical and phospholipase activity tests, 100% molecular sequence identities, and close proximity in the phylogenetic trees. Conclusion: The isolation of M. pachydermatis from humans and their dogs with identity based on biochemical, physiological, molecular, and phylogenetic perspectives indicate the ability of this species to adapt to new hosts and its potential for zoonotic transmission. These findings contribute to knowledge of the ecology of this important fungus in human and veterinary medicine. 展开更多
关键词 MALASSEZIA Transmission Animals Humans ZOONOSIS
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Infection of <i>Toxoplasma gondii</i>in Humans and Livestock Animals: An Emerging Silent Threat for Bangladesh 预览
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作者 Taibur Rahman Atiqur Rahman Sajib Chakraborty 《医学微生物学(英文)》 2018年第4期109-117,共9页
Toxoplasma gondii is an intracellular, zoonotic protozoan parasite that causes toxoplasmosis. It can potentially infect almost all mammalian and avian hosts including one-third of the human population world-wide. The ... Toxoplasma gondii is an intracellular, zoonotic protozoan parasite that causes toxoplasmosis. It can potentially infect almost all mammalian and avian hosts including one-third of the human population world-wide. The major target group of the parasite includes immunocompromised patients (e.g. AIDS, cancer, organ transplantation) and fetus bearing pregnant women where it develops toxoplasmic encephalitis, myocarditis, chorioretinitis and abnormal fetal brain development or stillbirths respectively. In this review, we have presented the current status of T. gondii infection in livestock animals and human population in Bangladesh to assess the country-wide relative risk. Although exact prevalence is difficult to predict due to the scarcity of data, nevertheless existing literature suggests that 16% - 39% humans and 8% - 70% domestic animals are infected with T. gondii, which implies Bangladeshi population is at high risk of toxoplasmosis. Furthermore, we have proposed a potential area of research to decipher the genetic diversity and transmission routes of T. gondii infection into Bangladeshi population. 展开更多
关键词 Toxoplasma GONDII Seroprevalence LIVESTOCK ANIMALS Humans BANGLADESH
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载脂蛋白M对高糖诱导的人视网膜血管内皮细胞中相关炎性因子表达的抑制作用 预览 被引量:1
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作者 唐皖 罗光华 +5 位作者 姚霜 王敏 潘丽莉 喻妙梅 于洋 刘瑶 《中华实验眼科杂志》 CSCD 北大核心 2018年第3期194-198,共5页
目的观察高糖培养环境下人视网膜血管内皮细胞(HRECs)中载脂蛋白M(ApoM)、肿瘤坏死因子-α(TNF-α)和单核细胞趋化因子-1(MCP-1)表达的变化,探讨ApoM过表达对高糖诱导的HRECs中TNF-α和MCP-1表达的抑制作用。方法采用含体积分... 目的观察高糖培养环境下人视网膜血管内皮细胞(HRECs)中载脂蛋白M(ApoM)、肿瘤坏死因子-α(TNF-α)和单核细胞趋化因子-1(MCP-1)表达的变化,探讨ApoM过表达对高糖诱导的HRECs中TNF-α和MCP-1表达的抑制作用。方法采用含体积分数10%胎牛血清(FBS)和5.5 mmol/L D-葡萄糖的DMEM培养基培养HRECs后分为6个组。正常对照组细胞进行常规培养,高糖组细胞用含30 mmol/L D-葡萄糖的高糖培养基进行培养,ApoM过表达组用载有ApoM序列的慢病毒载体感染常规培养的细胞,空载组用无ApoM序列的慢病毒载体感染常规培养的细胞,空载+高糖组用高糖培养基培养空载体感染的细胞,ApoM过表达+高糖组用高糖培养基培养ApoM感染的细胞。采用实时荧光定量PCR法检测细胞中ApoM、TNF-α和MCP-1 mRNA相对表达量;采用Western blot法检测细胞中ApoM蛋白相对表达量。结果实时荧光定量PCR法检测显示,高糖组细胞中ApoM、TNF-α和MCP-1 mRNA相对表达量明显高于正常对照组,差异均有统计学意义(t=5.517、3.295、2.555,均P〈0.05)。HRECs感染慢病毒后生长良好,ApoM过表达组细胞中ApoM mRNA相对表达量为236.400±39.270,明显高于空载组的1.000±0.153,差异有统计学意义(t=5.995,P〈0.01),空载组细胞中未见ApoM蛋白表达条带,ApoM过表达组蛋白表达条带较强。正常培养基和高糖培养基培养后24 h,ApoM过表达组中ApoM蛋白相对表达量分别为1.000±0.249和2.978±0.285,差异有统计学意义(t=5.056,P〈0.01)。空载组、空载+高糖组、ApoM过表达组、ApoM过表达+高糖组细胞中TNF-α和MCP-1 mRNA相对表达量的总体比较差异均有统计学意义(F=5.966,P=0.026;F=14.410,P=0.002),ApoM过表达+高糖组细胞中TNF-α mRNA和MCP-1 mRNA相对表达量明显低于空载+高糖组,差异均有统计学意义(P=0.017、0.004)。 结论高糖培养� 展开更多
关键词 载脂蛋白M 葡萄糖/药物作用 炎症反应 视网膜 血管内皮细胞 单核细胞趋化 因子-1 肿瘤坏死因子-α
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《毕司沃斯先生的房子》的生态解读 预览
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作者 张奇才 王婷婷 《哈尔滨学院学报》 2018年第1期109-111,共3页
文章从生态批评角度解读奈保尔的代表作《毕司沃斯先生的房子》,指出作品中反映的第三世界前殖民地国家生态破坏的具体表现:人类的各种产业活动侵犯、污染了自然的领地,影响了自然界中动植物的生存,破坏了自然的和谐与美感;生态系... 文章从生态批评角度解读奈保尔的代表作《毕司沃斯先生的房子》,指出作品中反映的第三世界前殖民地国家生态破坏的具体表现:人类的各种产业活动侵犯、污染了自然的领地,影响了自然界中动植物的生存,破坏了自然的和谐与美感;生态系统中物种之一的人类在肮脏、破败的环境中孤立无助地遭受着精神和肉体的病痛。 展开更多
关键词 生态批评 人类 自然 审美
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Attaining Human Aspects to Avoid Alienation in Architecture 预览
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作者 Saqer Mustafa Sqour 《土木工程与建筑:英文版》 2018年第2期121-131,共11页
Architectural practice during the last century was influenced by Western architectural theories.These theories were reflections of the contradictions of human beings’lives:the result was contradictions in architectur... Architectural practice during the last century was influenced by Western architectural theories.These theories were reflections of the contradictions of human beings’lives:the result was contradictions in architecture.The research aims to launch a view of the fundamentals of what we might call Muslim architectural theory,fundamentals that can control the future of architecture.Thus,it offers a set of principles coming from Muslim thought;these principles highlight humanitarian needs to be fulfilled by architecture.This paper makes the following assumptions:(1)Re-forming architecture requires re-forming the human.(2)The interaction between the social environment on one side and the built environment on the other side achieves human comfort.(3)Principles derived from Muslim thought set up general rules that can order architectural practice.Based on these theories,this paper has a goal of crystallizing a new theory that governs present-day architecture.Thus,the paper studies human needs in architecture.Besides,it has an implementation part to explain how architecture fulfills human needs.It further shows the extent to which the built environment can satisfy those needs.The research includes thirty needs traced from Muslim thought.Consequently,the research examined the presence of these needs in one traditional Arabian house. 展开更多
关键词 HUMANITY in ARCHITECTURE ALIENATION in ARCHITECTURE HUMAN ASPECTS in ARCHITECTURE ARCHITECTURE for humans
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Diagnosis and management of fibromuscular dysplasia and segmental arterial mediolysis in gastroenterology field:A mini-review 预览
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作者 Masayoshi Ko Kenya Kamimura +6 位作者 Kohei Ogawa Kentaro Tominaga Akira Sakamaki Hiroteru Kamimura Satoshi Abe Kenichi Mizuno Shuji Terai 《世界胃肠病学杂志:英文版》 SCIE CAS 2018年第32期3637-3649,共13页
The vascular diseases including aneurysm,occlusion,and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients.With the development ... The vascular diseases including aneurysm,occlusion,and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients.With the development and improvement of imaging modalities,diagnostic frequency of these vascular diseases in abdominal lesions is increasing even with the small changes in the vasculatures.Among various vascular diseases,fibromuscular dysplasia(FMD)and segmental arterial mediolysis(SAM)are noninflammatory,nonatherosclerotic arterial diseases which need to be diagnosed urgently because these diseases could affect various organs and be lethal if the appropriate management is not provided.However,because FMD and SAM are rare,the cause,prevalence,clinical characteristics including the symptoms,findings in the imaging studies,pathological findings,management,and prognoses have not been systematically summarized.Therefore,there have been neither standard diagnostic criteria nor therapeutic methodologies established,to date.To systematically summarize the information and to compare these disease entities,we have summarized the characteristics of FMD and SAM in the gastroenterological regions by reviewing the cases reported thus far.The information summarized will be helpful for physicians treating these patients in an emergency care unit and for the differential diagnosis of other diseases showing severe abdominal pain. 展开更多
关键词 Fibromuscular DYSPLASIA SEGMENTAL arterial mediolysis MESENTERIC lesion diagnosis Humans
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