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Comparisons of ganglion cell-inner plexiform layer loss patterns and its diagnostic performance between normal tension glaucoma and primary open angle glaucoma: a detailed, severity-based study
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作者 Xiao-Yu Xu Kun-Bei Lai +3 位作者 Hui Xiao Yi-Quan Lin Xin-Xing Guo Xing Liu 《国际眼科杂志:英文版》 SCIE CAS 2020年第1期71-78,共8页
AIM: To evaluate the patterns of macular ganglion cell-inner plexiform layer(GCIPL) loss in normal tension glaucoma(NTG) and primary open angle glaucoma(POAG) in a detailed, disease severity-matched way;and to assess ... AIM: To evaluate the patterns of macular ganglion cell-inner plexiform layer(GCIPL) loss in normal tension glaucoma(NTG) and primary open angle glaucoma(POAG) in a detailed, disease severity-matched way;and to assess the diagnostic capabilities of GCIPL thickness parameters in discriminating NTG or POAG from normal subjects.METHODS: A total of 157 eyes of 157 subjects, including 57 normal eyes, 51 eyes with POAG and 49 eyes with NTG were enrolled and strictly matched in age, refraction, and disease severity between POAG and NTG groups. The average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness, and the average, superior, temporal, inferior, and nasal retinal nerve fiber layer(RNFL) thickness were obtained by Cirrus optical coherence tomography(OCT). The diagnostic capabilities of OCT parameters were assessed by area under receiver operating characteristic(AUROC) curves. RESULTS: Among all the OCT thickness parameters, no statistical significant difference between NTG group and POAG group was found(all P>0.05). In discriminating NTG or POAG from normal subjects, the average and inferior RNFL thickness, and the minimum GCIPL thickness had better diagnostic capabilities. There was no significant difference in AUROC curve between the best GCIPL thickness parameter(minimum GCIPL) and the best RNFL thickness parameter in discriminating NTG(inferior RNFL;P=0.076) and indiscriminating POAG(average RNFL;P=0.913) from normal eyes.CONCLUSION: Localized GCIPL loss, especially in the inferior and inferotemporal sectors, is more common in NTG than in POAG. Among all the GCIPL thickness parameters, the minimum GCIPL thickness has the best diagnostic performance in differentiating NTG or POAG from normal subjects, which is comparable to that of the average and inferior RNFL thickness. 展开更多
关键词 normal tension glaucoma primary open angle glaucoma spectral domain optical coherence tomography ganglion cell-inner plexiform layer thickness PATTERN
白内障伴青光眼患者采用超声乳化与小梁切除治疗后胰岛素抵抗及炎性因子的变化:自身对照研究 预览
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作者 赵剑峰 耿宇 +2 位作者 陈前波 杨静晖 李燕 《中国组织工程研究》 CAS 北大核心 2020年第11期1750-1755,共6页
背景:白内障伴青光眼患者经超声乳化联合小梁切除治疗后,血脂比和胰岛素敏感性与其眼内压、视力和角膜内皮细胞等疗效相关指标均相关,可能用于其疗效的辅助评估。白细胞介素是机体内炎症反应的主要参与者和调解者,且参与了白内障的病理... 背景:白内障伴青光眼患者经超声乳化联合小梁切除治疗后,血脂比和胰岛素敏感性与其眼内压、视力和角膜内皮细胞等疗效相关指标均相关,可能用于其疗效的辅助评估。白细胞介素是机体内炎症反应的主要参与者和调解者,且参与了白内障的病理学过程。目的:试验将从炎性因子角度,进一步观察白内障伴青光眼患者术后炎性因子白细胞介素10、白细胞介素2及白细胞介素10水平变化,分析胰岛素敏感性与角膜内皮细胞密度的相关性,以了解其是否可用于疗效评估。方法:此项目设计为前瞻性、单中心、开放性、自身对照研究。拟纳入来自中国云南省,昆明医科大学第一附属医院眼科的白内障伴青光眼患者160例,年龄35-65岁,均进行超声乳化联合小梁切除治疗,随访时间为术后5 d及术后1,3个月。试验资料收集和招募对象时间为2019-12-30/2020-12-30,结果分析时间为2021-05-01/30,试验完成时间为2021-06-30。试验经昆明医科大学第一附属医院医学伦理委员会批准(审批时间:2013-12-15,审批号:20131215085)。研究符合世界医学会制定的《赫尔辛基宣言》的要求,患者均签署知情同意书。试验已在中国临床试验注册中心注册(注册号:ChiCTR1900025837),注册时间:2019-09-10,方案版本号1.0。结果与结论:试验的主要结局指标为术后3个月反映炎性反应情况的血清白细胞介素2水平变化;次要结局指标为术前、术后5 d及1个月血清白细胞介素2水平,术前、术后5 d及术后1,3个月血清白细胞介素1β、白细胞介素10、C-反应蛋白、肿瘤坏死因子α水平、最佳矫正视力、内皮细胞密度、平均细胞面积、面积变异系数、胰岛素敏感指数及眼内压变化,术后5 d及术后1,3个月的不良反应发生率变化。课题组已于2014年1月至2017年6月完成了80例(95眼)白内障伴青光眼患者以此方法干预的小样本试验,结果显示,超声乳化� 展开更多
关键词 胰岛素抵抗 青光眼 白内障 小梁切除术 超声乳化 胰岛素敏感指数 角膜内皮细胞 白细胞介素 C-反应蛋白 肿瘤坏死因子α 组织工程
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青光眼与房水生物标志物研究进展 预览
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作者 张勇 朱小敏 谢琳 《中国眼耳鼻喉科杂志》 2020年第1期66-68,共3页
青光眼是一组以视神经萎缩和视野缺损为主要特征的疾病。目前对于青光眼的研究越来越多,但是有很多问题仍未解决,如高危人群的筛查、青光眼的早期诊断、疾病进程的判断和治疗效果的预测等。寻找青光眼的生物标志物有助于探索青光眼的发... 青光眼是一组以视神经萎缩和视野缺损为主要特征的疾病。目前对于青光眼的研究越来越多,但是有很多问题仍未解决,如高危人群的筛查、青光眼的早期诊断、疾病进程的判断和治疗效果的预测等。寻找青光眼的生物标志物有助于探索青光眼的发病机制、辅助诊断和判断青光眼进程、评估治疗效果。本文综述目前有关青光眼患者房水生物标志物的研究进展。 展开更多
关键词 青光眼 房水 生物标志物
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基于AGREE II对青光眼临床指南质量评价
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作者 叶聪 王晓燕 +5 位作者 孟京亚 蓝园 吴海霞 李敏 吕帆 梁远波 《中华眼视光学与视觉科学杂志》 CAS CSCD 2020年第1期1-7,共7页
目的:了解青光眼临床指南的质量现状,为中国青光眼指南使用推荐提供参考。方法:文献研究。使用指南研究和评估工具AGREE II对美国眼科学会指南(AAO-PAC、AAO-POAG、AAO-POAGS)、欧洲青光眼指南(EGS)、国际眼科协会青光眼指南(ICO)、亚... 目的:了解青光眼临床指南的质量现状,为中国青光眼指南使用推荐提供参考。方法:文献研究。使用指南研究和评估工具AGREE II对美国眼科学会指南(AAO-PAC、AAO-POAG、AAO-POAGS)、欧洲青光眼指南(EGS)、国际眼科协会青光眼指南(ICO)、亚太青光眼指南(APGG)以及中国原发性青光眼诊断和治疗专家共识(CG)进行质量评价。对评估所得的各领域得分采用均数±标准差进行描述,通过组内相关系数对评估的可靠性进行分析。结果:组内相关系数均大于0.9。范围和目的及清晰性的得分较高,其余4项得分相对较低。各项领域得分分别为84%±19%(领域1,范围和目的),37%±18%(领域2,参与人员),25%±25%(领域3,严谨性),90%±16%(领域4,清晰性),34%±10%(领域5,应用性),40%±34%(领域6,独立性)。AAO-POAGS各领域得分为99%、42%、61%、97%、41%、77%。我国2014年版CG的各领域得分分别为47%、4%、8%、57%、17%、0%。结论:在目前各国的青光眼指南中,AAO-POAGS最值得优先推荐,2014年版CG尚未达到AGREE II关于指南推荐的标准,未来中国的青光眼循证指南制定过程需更加透明化和严谨,参与制定人员组成需更加多元化。 展开更多
关键词 临床实践指南 质量评价 指南研究和评估工具 青光眼
Centurion超声乳化玻璃体切割系统对青光眼白内障联合术中房水迷流的作用 预览
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作者 张建辉 林力平 林青霞 《眼科新进展》 CAS 北大核心 2020年第1期79-82,共4页
目的探讨Centurion超声乳化玻璃体切割系统处理青光眼白内障联合术中房水迷流的安全性和有效性。方法回顾性分析7例12眼青光眼白内障联合术中出现房水迷流的患者资料,术中应用Centurion的前节玻璃体切割程序应对房水迷流,观察手术前后... 目的探讨Centurion超声乳化玻璃体切割系统处理青光眼白内障联合术中房水迷流的安全性和有效性。方法回顾性分析7例12眼青光眼白内障联合术中出现房水迷流的患者资料,术中应用Centurion的前节玻璃体切割程序应对房水迷流,观察手术前后患者眼压、前房深度、角膜内皮细胞计数、滤过泡及术中、术后并发症发生情况。结果患者术中出现不同程度房水迷流,进行前节玻璃体切割后前房深度恢复,均顺利完成超声乳化;术后前房均形成;术后1周,1眼出现脉络膜脱离前房浅Ⅰ度,予以激素治疗及加压包扎,1周后前房恢复正常,所有患者未再有浅前房情况出现。治疗前患者眼压为(39.75±13.19)mmHg(1 kPa=7.5 mmHg),术后1个月眼压为(13.23±2.68)mmHg、术后3个月眼压为(14.19±1.79)mmHg,随访期间不需要辅助抗青光眼滴眼液治疗。术后1个月、3个月角膜内皮细胞计数与术前相比,差异均有统计学意义(均为P<0.05)。随访期间未见视网膜脱离、玻璃体积血、滤过泡无功能等并发症出现。结论Centurion超声乳化玻璃体切割系统作为青光眼白内障联合术中房水迷流的快速有效应对手段,可降低浅前房操作下角膜内皮损伤的风险,规避了因房水迷流引起的术中、术后浅前房并发症,节省了手术时间和治疗费用,使得该手术更加安全、经济和有效。 展开更多
关键词 房水迷流 Centurion超声乳化玻璃体切割系统 超声乳化术 小梁切除术 白内障 青光眼
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Analysis of the present situation and influencing factors of self-perceived burden in primary glaucoma patients 预览
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作者 Fu-Liang Sun Xiao-Hui An Shu-Qing Cao 《TMR整合护理》 2020年第1期15-21,共7页
Objective:To explore the status of self-perceived burden(SPB)in primary glaucoma patients and to analyze its influencing factors.Subject and setting:A questionnaire survey was administered to 236 inpatients from a ter... Objective:To explore the status of self-perceived burden(SPB)in primary glaucoma patients and to analyze its influencing factors.Subject and setting:A questionnaire survey was administered to 236 inpatients from a tertiary general hospital and a eye hospital in Tianjin.The investigation was conducted after obtaining informed consent from each participant.Instruments:They were investigated using general data questionnaire,Self-Perceived Burden Scale(SPBS),Medical Coping Modes Questionnaire(MCMQ).Design:A descriptive cross-sectional design was used to gather data in this study.Results:The total SPBS score of primary glaucoma patients was(31.10±9.34)was medium.Regression consults showed that avoidance and surrender coping style,medical burden and right eye vision were the influencing factors of patients’SPB(P<0.05).Conclusion:Patients with primary glaucoma have a relatively heavy SPB,so medical staff should encourage them to actively face it.Tailored strategies in line with the patient’s economic and visual conditions to reduce the SPB. 展开更多
关键词 Primary glaucoma Self-perceived burden Root cause analysis
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Mechanism study of trans-lamina cribrosa pressure difference correlated to optic neuropathy in individuals with glaucoma
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作者 Qingfeng Liang Leying Wang Xuyang Liu 《中国科学:生命科学英文版》 SCIE CAS CSCD 2020年第1期148-151,共4页
Glaucoma is the second leading cause of blindness after cataract worldwide.However,among irreversible blinding eye diseases,glaucoma is the primary cause(Liang et al.,2011).To date,most studies have indicated that gla... Glaucoma is the second leading cause of blindness after cataract worldwide.However,among irreversible blinding eye diseases,glaucoma is the primary cause(Liang et al.,2011).To date,most studies have indicated that glaucoma is not only an ocular disease,but also an optic nerve disease.In particular,primary open-angle glaucoma(POAG)is characterized by insidious onset,painless visual impairment,and complicated pathological mechanism,and patients with such condition require long-term follow-up.However,the underlying cause of POAG remains unclear,and there are several theories about its exact etiology.Some mechanisms have presented underlying optic nerve damage,which include the mechanical theory,vascular theory,and the in・volvement of other factors. 展开更多
关键词 GLAUCOMA al. CATARACT
血管新生性青光眼患者房水中EPO、VEGF的表达研究 预览
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作者 许多 阳建政 +3 位作者 刘莛 刘华 朗敏 贺翔鸽 《国际检验医学杂志》 CAS 2020年第1期78-81,86共5页
目的 探讨血管新生性青光眼(NVG)患者房水中促红细胞生成素(EPO)、血管内皮生长因子(VEGF)检测表达及其与眼血流动力学及氧化应激状况的相关性,为NVG的诊治提供依据。方法 选择2017年1月至2018年12月在中国人民解放军陆军特色医学中心(... 目的 探讨血管新生性青光眼(NVG)患者房水中促红细胞生成素(EPO)、血管内皮生长因子(VEGF)检测表达及其与眼血流动力学及氧化应激状况的相关性,为NVG的诊治提供依据。方法 选择2017年1月至2018年12月在中国人民解放军陆军特色医学中心(下称该院)门诊收治的血管新生性青光眼患者35例为研究对象,将其设置为研究组;另选择同期该院收治的原发性青光眼患者35例为对照组。采用酶联免疫法检测两组患者房水中EPO及VEGF表达水平,同时使用超声检测患者眼血流动力学参数及氧化应激状况,并分析其相关性。结果 研究组EPO及VEGF水平分别为(192.34±10.27)ng/mL、(1 089.14±52.18)U/L,显著高于对照组的(49.13±5.48)ng/mL、(305.26±20.58)U/L,差异有统计学意义(P<0.05);研究组视网膜中央动脉EDV、PSA水平及腱状后短动脉EDV、PSA水平分别为(2.51±0.32)、(8.12±1.08)、(2.64±0.41)、(9.74±1.17)cm/s,显著低于对照组的(3.84±0.47)、(12.54±2.16)、(3.75±0.52)、(15.53±2.06)cm/s,差异有统计学意义(P<0.05);研究组患者房水中EPO及VEGF表达水平与视网膜中央动脉EDV、PSA水平及腱状后短动脉EDV、PSA水平存在显著的负相关(r=-0.374,P=0.000);研究组房水中MDA、AOPP水平分别为(3.48±0.49)、(2.51±0.58)nmol/mL显著高于对照组的(1.86±0.18)、(1.09±0.16)nmol/mL,差异有统计学意义(P<0.05);研究组房水中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)水平分别为(21.36±3.46)、(15.97±3.15)、(9.14±2.83)U/mL显著低于对照组的(59.15±8.09)、(42.12±6.76)、(24.12±4.14)U/mL,差异有统计学意义(P<0.05);研究组患者房水中EPO及VEGF表达水平与MDA、AOPP水平呈正相关(r=0.671,P=0.000),与SOD、GSH-Px、CAT水平呈负相关(r=-0.592,P=0.000)。结论NVG患者房水中EPO及VEGF表达水平显著高于原发性青光眼患者,且与眼血流动力学及氧化应激状况相关。检测EPO及VEGF在临床中的发病 展开更多
关键词 青光眼 新生血管性 促红细胞生成素 血管内皮生长因子 眼血流动力学 氧化应激 眼房水
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1990—2015年中国主要眼病负担变化趋势分析 预览
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作者 胡健萍 王冰松 +4 位作者 董文兰 曹凯 赵爱萍 胡爱莲 王宁利 《医学综述》 2020年第1期159-163,168,共6页
目的分析1990—2015年中国主要眼病负担随时间的变化趋势。方法利用全球疾病负担、伤害和危险因素研究2016数据对1990—2015年中国眼病负担进行汇总,分析屈光调节异常、白内障、青光眼、黄斑变性以及沙眼的全年龄组伤残损失寿命年(YLD)... 目的分析1990—2015年中国主要眼病负担随时间的变化趋势。方法利用全球疾病负担、伤害和危险因素研究2016数据对1990—2015年中国眼病负担进行汇总,分析屈光调节异常、白内障、青光眼、黄斑变性以及沙眼的全年龄组伤残损失寿命年(YLD)、全年龄组YLD率和标准化YLD率。结果1990—2015年,我国屈光调节异常、白内障、青光眼、黄斑变性的全年龄组YLD和全年龄组YLD率均呈逐年上升趋势,沙眼基本维持不变;排除人口规模和年龄结构的影响,标准化YLD率显示,屈光调节异常1990—2015年的健康损失逐渐下降,2000年达到最低,2000—2015年缓慢增高;白内障1990—2015年的健康损失有所增长,1995年达到最高,随后于2000年回落,2000—2010年基本不变,2010—2015年逐渐减少,2015年达到近25年的最低水平;青光眼1990—2015年的健康损失缓慢增长,增长幅度较平稳,2015年较1990年增长42.2%;黄斑变性1990—2015年的健康损失快速增长,增长幅度较大,2015年较1990年增长73.4%;沙眼1990—2015年的健康损失略有升高,随后迅速下降,至2015年趋于消失。结论1990—2015年,去除人口规模和年龄结构的影响,我国白内障和沙眼的控制较理想,而屈光调节异常、青光眼、黄斑变性的疾病负担有所增加。 展开更多
关键词 白内障 青光眼 黄斑变性 伤残损失寿命年
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Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis
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作者 Patrick Murtagh Garrett Greene Colm O'Brien 《国际眼科杂志:英文版》 SCIE CAS 2020年第1期149-162,共14页
AIM: To compare the effectiveness of two well described machine learning modalities, ocular coherence tomography(OCT) and fundal photography, in terms of diagnostic accuracy in the screening and diagnosis of glaucoma.... AIM: To compare the effectiveness of two well described machine learning modalities, ocular coherence tomography(OCT) and fundal photography, in terms of diagnostic accuracy in the screening and diagnosis of glaucoma. METHODS: A systematic search of Embase and Pub Med databases was undertaken up to 1 st of February 2019. Articles were identified alongside their reference lists and relevant studies were aggregated. A Meta-analysis of diagnostic accuracy in terms of area under the receiver operating curve(AUROC) was performed. For the studies which did not report an AUROC, reported sensitivity and specificity values were combined to create a summary ROC curve which was included in the Meta-analysis.RESULTS: A total of 23 studies were deemed suitable for inclusion in the Meta-analysis. This included 10 papers from the OCT cohort and 13 from the fundal photos cohort. Random effects Meta-analysis gave a pooled AUROC of 0.957(95%CI=0.917 to 0.997) for fundal photos and 0.923(95%CI=0.889 to 0.957) for the OCT cohort. The slightly higher accuracy of fundal photos methods is likely attributable to the much larger database of images used to train the models(59 788 vs 1743). CONCLUSION: No demonstrable difference is shown between the diagnostic accuracy of the two modalities. The ease of access and lower cost associated with fundal photo acquisition make that the more appealing option in terms of screening on a global scale, however further studies need to be undertaken, owing largely to the poor study quality associated with the fundal photography cohort. 展开更多
关键词 machine learning GLAUCOMA ocular coherence tomography fundal photography DIAGNOSIS META-ANALYSIS
Proteome alterations in aqueous humour of primary open angle glaucoma patients
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作者 Hanhan Liu Fabian Anders +3 位作者 Sebastian Funke Karl Mercieca Franz Grus Verena Prokosch 《国际眼科杂志:英文版》 SCIE CAS 2020年第1期176-179,共4页
AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy f... AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap Mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the Maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably altered.RESULTS: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as controls.CONCLUSION: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins. 展开更多
关键词 primary open angle glaucoma aqueous humor PROTEOMICS Wnt signaling pathway
Ultrasound cyclo plasty for the management of glaucoma secondary to ocular irradiation for choroidal melanoma
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作者 Stefano Sebastiani Mónica Asencio-Durán +8 位作者 Cosme Lavín-Dapena Beatriz ManzanoMuñoz Oriana D’Anna-Mardero Rosa Cordero-Ros Marco Pellegrini Federico Bernabei Andrea Mercanti Vincenzo Scorcia Giuseppe Giannaccare 《国际眼科杂志:英文版》 SCIE CAS 2020年第1期184-188,共5页
Dear Editor,In the past, enucleation has been considered the only available option and the standard of care for the management of malignant intraocular tumors. Thanks to the advances in the field of radiotherapy, new ... Dear Editor,In the past, enucleation has been considered the only available option and the standard of care for the management of malignant intraocular tumors. Thanks to the advances in the field of radiotherapy, new therapeutic approaches have been developed in the last decades, such as plaque brachytherapy and proton beam therapy(PBT)~([1]). 展开更多
关键词 OCULAR THERAPY GLAUCOMA
雷帕霉素眼用缓释膜的制备及体外释放分析 预览
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作者 颜志超 游秀华 邓彩彬 《中山大学学报(医学版)》 CAS CSCD 北大核心 2020年第1期143-148,共6页
[目的]制备雷帕霉素(RAPA)眼用缓释膜,并评价其体外释放性能。[方法]利用聚乳酸(PLA)和聚糖酸(PGA)的共聚物聚乳糖酸(PLGA)为载体与RAPA制成眼用缓释膜,并对该缓释膜的药物含量进行测定(包括缓释膜的专属性考察、回收率、精密度及稳定... [目的]制备雷帕霉素(RAPA)眼用缓释膜,并评价其体外释放性能。[方法]利用聚乳酸(PLA)和聚糖酸(PGA)的共聚物聚乳糖酸(PLGA)为载体与RAPA制成眼用缓释膜,并对该缓释膜的药物含量进行测定(包括缓释膜的专属性考察、回收率、精密度及稳定性的测定),以及缓释膜的体外释放分析研究。[结果]通过RAPA标准曲线可知,RAPA浓度在0.408~40.8μg/mL范围内,与峰面积呈良好的线性关系;专属性考察发现缓释膜中辅料及0.3%SDS溶液对RAPA含量测定没有干扰,含量测定专属性好;对空白缓释膜加入高中低3组不同药物含量并检测其回收率和精密度结果均良好;通过RAPA缓释膜的药物含量测定分析,缓释膜平均RAPA含量为(112.6±10.1)μg/片(R SD8.99%);而RAPA稳定性测定也发现,以0.3%SDS溶液为释放介质的RAPA在15d内稳定性好。同时通过缓释膜体外释放研究发现,药物释放量在第5天达到峰值浓度,并持续维持至15d。[结论]一定行为学参数的RAPA眼用缓释膜具有良好的缓释性能,具有青光眼术后抗瘢痕化的应用潜力。 展开更多
关键词 雷帕霉素 缓释膜 体外释放 青光眼 抗瘢痕化
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Beneficial effects of saffron(Crocus sativus L.)in ocular pathologies,particularly neurodegenerative retinal diseases 预览
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作者 Jose A.Fernández-Albarral Rosa de Hoz +5 位作者 Ana I.Ramírez Inés López-Cuenca Elena Salobrar-García María D.Pinazo-Durán JoséM.Ramírez Juan J.Salazar 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第8期1408-1416,共9页
Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal plant.It currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as antic... Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal plant.It currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as anticonvulsant,antidepressant,anxiolytic,hypolipidemic,anti-atherogenic,anti-hypertensive,antidiabetic,and anti-cancer properties.In addition,saffron has remarkable beneficial properties,such as anti-apoptotic,anti-inflammatory and antioxidant activities,due to its main metabolites,among which crocin and crocetin stand out.Furthermore,increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,both in experimental models and in clinical studies in patients.Currently,saffron supplementation is being tested for ocular neurodegenerative pathologies,such as diabetic retinopathy,retinitis pigmentosa,age-related macular degeneration and glaucoma,among others,and shows beneficial effects.The present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular diseases.This review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases. 展开更多
关键词 AMD CROCETIN CROCIN Crocus sativus L. diabetic retinopathy glaucoma neuroprotection ocular diseases retinitis pigmentosa SAFFRON safranal
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他氟前列素对原发性开角型青光眼和高眼压症患者24小时眼压的影响
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作者 彭悦 赵平 +2 位作者 谭娟 刘瑞 郑伊苹 《中华眼视光学与视觉科学杂志》 CAS CSCD 2020年第1期27-31,共5页
目的:通过测量24 h眼压评估他氟前列素对原发性开角型青光眼(POAG)和高眼压症(OHT)患者的临床疗效。方法:系列病例研究。收集2018年1月至2019年3月在沈阳爱尔眼视光医院初次诊断的POAG和OHT患者22例(43眼),由医师对所有患者进行Icare H... 目的:通过测量24 h眼压评估他氟前列素对原发性开角型青光眼(POAG)和高眼压症(OHT)患者的临床疗效。方法:系列病例研究。收集2018年1月至2019年3月在沈阳爱尔眼视光医院初次诊断的POAG和OHT患者22例(43眼),由医师对所有患者进行Icare HOME眼压计操作培训及认证,认证合格后使用Goldmann压平眼压计(GAT)测量眼压3次,然后由患者使用Icare HOME眼压计自我监测用药前24 h眼压,之后每天2100给予他氟前列素点眼1次,1个月后患者自我监测用药后24 h眼压。采用单因素方差分析和Bland-Altman分析比较医师使用GAT和患者使用Icare HOME眼压计测量眼压的一致性。采用配对t检验分析患者使用他氟前列素治疗前后各个时间点的眼压值、24 h眼压均值、峰值、谷值和波动值的变化。结果:医师使用GAT和患者使用Icare HOME眼压计测量眼压的平均值分别为(18.2±3.7)mmHg(1 mmHg=0.133 kPa)和(17.4±4.2)mmHg,差异无统计学意义(F=0.837,P=0.363)。Bland-Altman分析证明医师使用GAT和患者使用Icare HOME眼压计测量眼压具有良好的一致性。使用他氟前列素治疗1个月后,所有评估时间点的眼压均降低(均P<0.05),不同时间点眼压降低的范围为1.8~5.5 mmHg。用药前24 h眼压均值、峰值、谷值、波动值分别为(19.4±5.0)、(25.0±5.8)、(14.1±4.5)、(10.9±3.8)mmHg,用药后分别降低至(15.6±4.2)、(20.4±4.5)、(11.3±3.6)、(9.2±2.9)mmHg,差异均有统计学意义(t=9.450、9.636、5.939、3.137,均P<0.05)。结论:对于初次诊断的POAG和OHT患者,他氟前列素可明显降低24 h中所有评估时间点的眼压。 展开更多
关键词 青光眼 开角型 高眼压 眼压测量法 他氟前列素
Expression and role of autophagy related protein p62 and LC3 in the retina in a rat model of acute ocular hypertension
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作者 Yu-Yu Wu Bing-Ru Zheng +3 位作者 Wan-Zhu Chen Mao-Sheng Guo Yi-Hong Huang Yan Zhang 《国际眼科杂志:英文版》 SCIE CAS 2020年第1期21-28,共8页
AIM: To investigate the expression and possible role of the autophagy related protein p62 and LC3 in the retina based on a rat model of acute ocular hypertension.METHODS: Fifty rats were randomized into five groups: c... AIM: To investigate the expression and possible role of the autophagy related protein p62 and LC3 in the retina based on a rat model of acute ocular hypertension.METHODS: Fifty rats were randomized into five groups: control group A, B, C, and D. Groups A to D all received normal saline perfusion into the anterior chamber with pressure of 80 mm Hg for one hour, and retina tissue was obtained at 6, 12, 24 and 48 h after perfusion respectively, to investigate the activation of autophagy following ischemiareperfusion. The distribution and semi-quantification of autophagy related protein p62 and LC3 in the retina were detected using immunohistochemistry technique. The expression level of these two proteins was evaluated using Western blot.RESULTS: The number of retinal ganglion cells(RGCs) decreased with increasing reperfusion time, and significant reduction in the retinal thickness was observed 48 h after perfusion. In normal adult rats, LC3 protein was mainly expressed in the ganglion cell layer(GCL), and p62 protein was expressed in the nerve fiber layer(NFL), GCL, inner plexiform layer(IPL), inner nuclear layer(INL) and outer plexiform layer(OPL). In comparison to the control group, the expression level of LC3-II was higher in all the experimental groups(P<0.05), with the peak expression at 12 h after reperfusion. Additionally, the expression level of p62 was higher in all the experimental groups than the control(P<0.05, except for group A), with the peak level occurred 24 h after reperfusion. CONCLUSION: Both p62 and LC3 show low level and uneven expression in the retina of normal adult rats. Acute ocular hypertension can lead to upregulation of LC3-II and p62 expression in the retina. Autophagy flux is damaged 12 h after reperfusion, potentially resulting in further loss of RGCs. 展开更多
关键词 GLAUCOMA acute ocular hypertension LC3 P62 AUTOPHAGY
高度近视合并青光眼患者视神经纤维层厚度的变化 预览
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作者 韦晓丹 刘荣 +4 位作者 甘亚平 王雪梅 吕建美 金丽珍 孔庆丽 《国际眼科杂志》 CAS 北大核心 2020年第2期343-345,共3页
目的:通过光学相干断层成像(OCT)检测高度近视合并青光眼患者视神经纤维层厚度的变化规律。方法:选取2017-01/12于我院进行治疗的高度近视合并青光眼患者80例160眼作为观察组,并选择同期于我院进行体检的健康志愿者60例120眼作为对照组... 目的:通过光学相干断层成像(OCT)检测高度近视合并青光眼患者视神经纤维层厚度的变化规律。方法:选取2017-01/12于我院进行治疗的高度近视合并青光眼患者80例160眼作为观察组,并选择同期于我院进行体检的健康志愿者60例120眼作为对照组。采用OCT分析所有受检者视神经纤维层厚度。结果:与对照组受检者相比,观察组患者鼻侧、颞上、鼻下、鼻上、颞下及全周平均视神经纤维层厚度均降低,而颞侧视神经纤维层厚度升高(P<0.05),且观察组中屈光度-10.00~-11.00D的患者鼻侧、颞上、鼻下、鼻上、颞下及全周平均视神经纤维层厚度均显著高于屈光度≥-12.00D的患者(P<0.05)。Spearman相关分析结果显示,观察组患者屈光度的绝对值与鼻侧、颞上、鼻下、颞下及全周平均厚度视神经纤维层厚度呈负相关,与颞侧视神经纤维层厚度呈正相关。结论:高度近视合并青光眼患者除颞侧外各象限视神经纤维层变薄。 展开更多
关键词 高度近视 青光眼 光学相干断层成像 视神经 纤维层厚度
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Normal tension glaucoma: from the brain to the eye or the inverse? 预览
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作者 Hui-Jun Zhang Xue-Song Mi Kwok-Fai So 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1845-1850,共6页
Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in whi... Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in which the patient’s intraocular pressure is within the normal range, but the patient experiences typical glaucomatous changes. However, increasing evidence has challenged the traditional pathophysiological view of normal tension glaucoma, which is based only on intraocular pressure, and breakthroughs in central nervous system imaging may now greatly increase our knowledge about the mechanisms underlying normal tension glaucoma. In this article, we review the latest progress in understanding the pathogenesis of normal tension glaucoma and in developing imaging techniques to detect it, to strengthen the appreciation for the connection between normal tension glaucoma and the brain. 展开更多
关键词 nerve REGENERATION normal tension GLAUCOMA open angle GLAUCOMA NEURODEGENERATIVE diseases visual field CEREBROSPINAL fluid pressure IMAGING techniques pathogenesis magnetic resonance IMAGING diffusion TENSOR IMAGING metabolic changes neural REGENERATION
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青光眼引流器Ex-PRESS植入及可调整缝线治疗难治性青光眼
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作者 屈宏波 赵军梅 《中华眼外伤职业眼病杂志》 2019年第8期598-601,共4页
目的评估Ex-PRESS青光眼引流器植入联合可调整缝线治疗难治性青光眼的效果。方法回顾性分析2013年2月至2018年4月难治性青光眼39例(39眼)的临床资料。所有患者行Ex-PRESS青光眼引流器植入联合应用可调整缝线治疗。结果术后6个月,矫正视... 目的评估Ex-PRESS青光眼引流器植入联合可调整缝线治疗难治性青光眼的效果。方法回顾性分析2013年2月至2018年4月难治性青光眼39例(39眼)的临床资料。所有患者行Ex-PRESS青光眼引流器植入联合应用可调整缝线治疗。结果术后6个月,矫正视力提高者12眼,无明显改变者24眼,视力下降3眼。术前平均眼压(47.49±10.16)mmHg(1 mmHg=0.133 kPa)。术后1天、1周、1、3及6个月平均眼压依次为(15.00±5.28)mmHg、(15.64±3.49)mmHg、(16.28±3.03)mmHg、(17.03±2.79)mmHg、(20.08±6.01)mmHg。术后各时间点眼压均低于术前,差异均有统计学意义(均为P=0.000)。结论Ex-PRESS青光眼引流器植入联合可调整缝线是难治性青光眼一种安全有效的治疗手段。 展开更多
关键词 引流器 青光眼 缝线 可调整 青光眼 难治性
Prevalence, Awareness and Factors Associated with Glaucoma in a Rural Community of Ekiti State, South West Nigeria 预览
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作者 Rasaq Kayode Adewoye Tayo Ibrahim +3 位作者 Shuaib Kayode Aremu Taiye Adeyanju Alao Makinde Adebayo Adeniyi Adewumi Bakare 《眼科学期刊(英文)》 2019年第1期18-27,共10页
Background: Glaucoma, a group of diseases that have optic neuropathy as a common end point, is the leading cause of irreversible blindness worldwide, accounting for 4.5 million blindness, which is about 12% of global ... Background: Glaucoma, a group of diseases that have optic neuropathy as a common end point, is the leading cause of irreversible blindness worldwide, accounting for 4.5 million blindness, which is about 12% of global blindness. This study aimed to assess the prevalence, awareness and risk factors associated with glaucoma in a rural community of Ekiti State. Methodology: This was a cross-sectional study conducted during a health outreach. All adults present during the outreach were enrolled into the study and screened for glaucoma and a semi-structured self-administered questionnaire was used for data collection. The validity of the questionnaire was tested at Ijero-Ekiti community before being used for this research. Data obtained was analysed using SPSS version 20 and p-value was predetermined at ≤ 0.05. Results: Majority of respondents were aged 60 years and above with a mean age of 55 ± 11.7. Majority (73%) were females and 41% had secondary education. Prevalence of glaucoma was 10.7%;36% of respondents had heard about glaucoma;and 43.2% of those that had heard were not aware that it can lead to blindness. Increasing age, level of education, procurement of glasses from friends/relatives/roadside, using eyes drop not prescribed, history of previous eyes injury and family history of glaucoma were factors identified as having significant relationship with glaucoma. Conclusion: Glaucoma is prevalent in the community (10.7%). However, level of awareness about the disease (36%) was low. Factors, such as age, level of education, procurement of glasses from quacks, use of eye drops not prescribed, previous injury to the eyes and family history of glaucoma, were shown to have significant relationship with glaucoma. There is need to increase community awareness on glaucoma as a major cause of blindness and the risk factors associated with it. Community screening for people above 40 years for glaucoma is also recommended. 展开更多
关键词 GLAUCOMA BLINDNESS NEUROPATHY
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