基金Acknowledgements： This work was supported by the National Basic Research Development Program of China （No. 2006CB500706）, the National Natural Science Foundation of China （No. 30700251, 30872729, 30971031）, Shanghai Key Discipline Program （No. S30202）, and the Program for Outstanding Medical Academic Leader （No. LJ 06003）. We thank Dr. Yue HUANG at Prince of Wales Medical Research Institute ＆ School of Medical Sciences, University of New South Wales, for critical reading of the manuscript.