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Use of the average age ratio method in analyzing age heaping in censuses:The case of China 预览
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作者 Danan Gu Qiushi Feng 《国际人口学期刊》 2019年第1期13-26,共14页
Based on the methods of the average period age ratio and the average cohort age ratio,this study systematically assesses age heaping or digit preference in all population censuses of China.Our study finds that the ove... Based on the methods of the average period age ratio and the average cohort age ratio,this study systematically assesses age heaping or digit preference in all population censuses of China.Our study finds that the overall age heaping was relatively low in the Chinese censuses;however,there was a notable preference for ages ending with zero after age 50 in the first two censuses,despite a weakening trend over time.Our study further shows that age heaping in China’s censuses is likely associated with age-related policies such as those on late marriage and retirement.As shown in the study,the average age ratio method can be an alternative of the Whipple’s Index and be improved if the size of birth cohort was taken into account when the number of births is generally reliable. 展开更多
关键词 Age concentration INDEX Age heaping age RATIO Age reporting AVERAGE age RATIO AVERAGE period age RATIO AVERAGE cohort age RATIO China CENSUS DIGIT preference DIGIT AVOIDANCE Whipple’s INDEX Myer’s blended INDEX
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THE EFFECTS OF COMBINING APPLICATION OF DIAGNOSIS AND TREATMENT TECHNOLOGIES OF ERP AND PSYCHIC REHABILITATION INTERVENTION ON REHABILITATION OF SCHIZOPHRENIA 预览
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作者 Song Lisheng Zhang Chen +15 位作者 Chen Meijuan Zhang Yi Li Xiaoping Zhao Wenqing Yang Xujiao Huang Xinrui Lin Xiaodong Chen Ce Wang Xiwu Wu Rongqin Xu Lu Tang Jialin Wang Zuowei Zhan Guilai Zhang Zhanxing He Qiuhao 《现代电生理学杂志》 2019年第B03期19-27,共9页
Objective:To explore the effects of combining application of diagnosis and treatment technologies of Event Related Potentials(ERP)and Psychic Rehabilitation Intervention(PRI)on rehabilitation of schizophrenia.Methods:... Objective:To explore the effects of combining application of diagnosis and treatment technologies of Event Related Potentials(ERP)and Psychic Rehabilitation Intervention(PRI)on rehabilitation of schizophrenia.Methods:PRI and ERP were used in schizophrenia rehabilitation in this research.232 patients were divided into study group(SG)and control group(CG),and the rehabilitation effects were compared.Results:(1)After the implementation of the PRI,more score of the Brief Psychiatric Rating Scale(BPRS)was reduced on SG than the score on CG;more decreased scores of insight and on Social Disability Screening Schedule(SDSS),and more increased scores of treatment compliance questionnaire scores were observed on SG,comparing with CG(P<0.05 or 0.01).(2)After the implementation of the PRI,more decreased factor scores of Symptom Checklist 90 were observed on SG patients family members(P<0.05 or 0.01).(3)PRI significantly improved the patients’social functions,family members’relationship and prevented the recurrence of schizophrenia.(4)Improved P2,P3 amplitudes were also detected on SG compared with CG(P<0.05).Conclusions:(1)PRI interventions may improve schizophrenia patients’social function.(2)ERP may be used to evaluate the schizophrenia patients’rehabilitation,and is worth being popularized. 展开更多
关键词 Event Related Potential COGNITIVE FUNCTION SCHIZOPHRENIA Rehablitation COGNITIVE FUNCTION Multple-center Perspective COHORT study
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Adenoma and advanced neoplasia detection rates increase from 45 years of age 预览
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作者 David Karsenti Gaelle Tharsis +7 位作者 Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第4期447-456,共10页
BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC).The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR).... BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC).The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR).Due to the fact that screening programs usually start from the age of 50,very few data are available on the risk of adenoma between 40 and 49 years.However,the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR)according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows:patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in 2016.We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS 6027 colonoscopies were performed in patients with a median age of 57 years(range,15-96).The ADR and ANDR were 28.6%and 9.7%,respectively,in the whole population.When comparing patients aged 40-44(n=382)and 45-49 years(n=515),a strong increase in all parameters from 45 years was observed,with the ADR rising from 9.7%in patients aged 40-44 to 21.2%between 45 and 49(P<0.001)and the ANDR increasing from 3.1%in patients aged 40-44 to 6.4%in those aged 45-49 years(P<0.03).With regard to patients aged 50-54(n=849),a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years.In the population with an average risk of CRC,the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This 展开更多
关键词 COLORECTAL cancer SCREENING ADENOMA detection rate COLONOSCOPY COHORT study
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流动模式与农民工婚姻稳定性研究:基于性别和世代的视角 预览
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作者 李卫东 《社会》 CSSCI 北大核心 2019年第6期23-61,共39页
基于广州2016年的“农民工社会融合与婚姻家庭调查”数据,本文从性别和世代的角度系统探讨了农民工的婚姻稳定性问题。分析结果表明,新生代农民工的婚姻稳定性显著低于第一代农民工,女性农民工婚姻稳定性低于男性农民工,且新生代女性农... 基于广州2016年的“农民工社会融合与婚姻家庭调查”数据,本文从性别和世代的角度系统探讨了农民工的婚姻稳定性问题。分析结果表明,新生代农民工的婚姻稳定性显著低于第一代农民工,女性农民工婚姻稳定性低于男性农民工,且新生代女性农民工婚姻稳定性最低。流动模式对农民工婚姻稳定性具有显著影响,且这种影响存在性别和世代差异,其中流动模式形塑着农民工的婚姻收益和离婚阻力,流动模式对农民工婚姻稳定性的影响,同时又受到具体的性别效应和世代效应的共同影响,其中的脆弱性差异机制可以解释流动模式对农民工婚姻稳定性影响的性别效应和世代效应。 展开更多
关键词 婚姻稳定性 农民工 人口流动 性别 世代
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Ideal Cardiovascular Health is Inversely Associated with Subclinical Atherosclerosis: A Prospective Analysis 预览
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作者 WANG Long NIU Jing Ya +12 位作者 ZHAO Zhi Yun LI Mian XU Min LU Jie Li WANG Tian Ge CHEN Yu Hong WANG Shuang Yuan DAI Meng LI Lin LIU Shan Shan WANG Wei Qing XU Yu BI Yu Fang 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第4期260-271,共12页
Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in... Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in a population cohort of Chinese adults aged ≥ 40 years. Methods This study was designed as a cross-sectional analysis of 8,395 participants who had complete data at baseline and a prospective analysis of 4,879 participants who had complete data at 4.3 years of follow-up. Ideal CVH metrics were defined according to the American Heart Association. Subclinical atherosclerosis was evaluated by plaques in carotid arteries, carotid intima-media thickness(CIMT), brachial-ankle pulse wave velocity(baPWV), and urinary albumin-to-creatinine ratio(UACR). Results Both the prevalence and incidence of atherosclerosis measures were found to be decreased with increasing numbers of ideal CVH metrics at baseline(all P values for trend < 0.01). The levels of CIMT and UACR at follow-up showed an inverse and significant association with the numbers of ideal CVH metrics at baseline(both P values for trend < 0.05) but a borderline significant association with baPWV(P for trend = 0.0505). Taking participants with 0-1 ideal metric as reference, we found that participants with 5-6 ideal metrics had significantly lower risks of developing carotid plaques(odds ratio, OR = 0.46;95% confidence interval, CI 0.27-0.79), increased CIMT(OR = 0.60;95% CI 0.42-0.84), and increased baPWV(OR = 0.57;95% CI 0.34-0.97) after full adjustments. A significant interactive effect of age and CVH was detected on CIMT and baPWV progression(both P values for interaction < 0.05). Conclusion The numbers of ideal CVH metrics showed a significant and inverse association with the risk of developing subclinical atherosclerosis in middle-aged and elderly Chinese adults, whereas its dose-response effect was attenuated in individuals aged ≥ 60 years and partially weakened in male participants. 展开更多
关键词 CARDIOVASCULAR health SUBCLINICAL ATHEROSCLEROSIS COHORT
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Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study 预览
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作者 Fahimeh Haghighatdoost Masoud Amini +2 位作者 Ashraf Aminorroaya Majid Abyar Awat Feizi 《世界糖尿病杂志:英文版(电子版)》 2019年第6期350-361,共12页
BACKGROUND The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM To examine the association of baseline metabolic/obesity phenotypes and their changes over time... BACKGROUND The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM To examine the association of baseline metabolic/obesity phenotypes and their changes over time with the risk of prediabetes development. METHODS In a population-based cohort study, 1741 adults (aged > 19 years) with normal blood glucose were followed for 14 years. Anthropometric and biochemical measures were evaluated regularly during the follow-up period. According to body mass index and metabolic health status, participants were categorized into four groups: Metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW) and metabolically unhealthy obese (MUO). Multivariable Cox regression analysis was used to measure the risk of prediabetes according to the baseline metabolic/obesity phenotype and their changes during the follow-up. RESULTS In the whole population with a mean (95CCI for mean) follow up duration of 12.7 years (12.6-12.9), all three MUNW, MHO, MUO groups were at higher risk for developing prediabetes compared to the MHNW group (P = 0.022). The MUNW group had the highest risk for developing prediabetes (hazard ratio (HR): 3.84, 95%CI: 1.20, 12.27). In stratified analysis by sex, no significant association was found in men, while women in the MUNW group were at the greatest risk for prediabetes (HR: 6.74, 95%CI: 1.53, 29.66). Transforming from each phenotype to MHNW or MHO was not related to the risk of prediabetes development, whereas transforming from each phenotype to MUO was associated with an increased risk of prediabetes (HR > 1;P < 0.05). CONCLUSION Our findings indicate that MHO is not a high risk, unless it transforms into MUO over time. However, people in the MUNW group have the greatest risk for developing prediabetes, and therefore, they should be screened and treated. 展开更多
关键词 PREDIABETES OBESITY METABOLIC status COHORT study
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Efficacy and safety of electroacupuncture in treatment of lumbar disc herniation: a protocol for a cohort study
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作者 Liu Yaru Zhao Jianxin Tian Yuanxiang 《中医杂志:英文版》 SCIE CAS CSCD 2019年第1期127-132,共6页
OBJECTIVE: To compare the efficacy of electroacupuncture(deep needling) and general orthopedics in treatment of lumbar disc herniation(LDH), and to evaluate its long-term efficacy.METHODS: This trial is a prospective ... OBJECTIVE: To compare the efficacy of electroacupuncture(deep needling) and general orthopedics in treatment of lumbar disc herniation(LDH), and to evaluate its long-term efficacy.METHODS: This trial is a prospective cohort study.A total of 175 participants will be observed. The exposure group is obtained from department of acupuncture and moxibustion and the control group is from orthopedic department in hospital. Patients in exposed group will receive electroacupuncture in Dachangshu(BL 25), Guanyuanshu(BL 26), L4 Jiaji points(EX-B2 L4), L5 Jiaji points(EX-B2 L5) and S1 Jiaji points(EX-B2 S1) in the affected side once a day, 6 times as a treatment course for two courses(12 times). Patients in control group will receive orthopedic conventional therapy. In acute period,the treatment is mannitol injection(250 mL∶50 g) 200 mL, i.v., q.d.;0.9% sodium chloride injection250 mL, vitamin C injection 2 g, Dexamethasone sodium phosphate injection 10 mg, i.v., q.d.;sterile water for injection 2 mL, adenosine cobalt amine injection 1 mg, i.m., q.d., 12 d. In remission period,the treatment is Voltaren(Diclofenac diethyl lamine emulsion) external, q.d., 12 d. The researchers do not give any other intervention and record the relevant information only.RESULTS: Modified Japanese Orthopaedic Association Scores, Visual Analogue Scale/Score, the Short Form-36 Quality-of-Life Questionnaire and Oswestry Disability Questionnaire and the second outcome measures(Adverse Event Questionnaire and Relapse Questionnaire) are measured before treatment, after the sixth treatment, and after the twelfth treatment. The follow-up periods are3 months after the twelfth treatment, 6 months after the twelfth treatment, 1 year after the twelfth treatment.CONCLUSION: This study will provide clinical researchers with the evidence on the safety and longterm efficacy of electroacupuncture in patients with Lumbar disc herniation. 展开更多
关键词 ELECTROACUPUNCTURE INTERVERTEBRAL DISC displacement Time PROSPECTIVE STUDIES COHORT STUDIES
中老年人血压变化轨迹与冠心病发病的关系
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作者 林伟强 王春霞 +4 位作者 李明卓 孙秀彬 刘言训 薛付忠 袁中尚 《山东大学学报:医学版》 CAS 北大核心 2019年第4期106-112,共7页
目的探索血压随年龄变化的轨迹与冠心病发病的关系。方法以健康体检纵向数据管理队列为基础,应用群组化轨迹模型(GBTM)分别建立研究对象的收缩压和舒张压血压变化轨迹发展模型,依据其轨迹发展模型分别对收缩压和舒张压两个子队列人群进... 目的探索血压随年龄变化的轨迹与冠心病发病的关系。方法以健康体检纵向数据管理队列为基础,应用群组化轨迹模型(GBTM)分别建立研究对象的收缩压和舒张压血压变化轨迹发展模型,依据其轨迹发展模型分别对收缩压和舒张压两个子队列人群进行轨迹分组;进而应用Cox回归模型分析子队列中不同轨迹变化组与冠心病发生的关联。结果收缩压和舒张压子队列分别包含1 215例和1 345例,随访期间两个子队列分别新发冠心病78例和86例。根据GBTM轨迹发展模型,可将收缩压子队列分为收缩压低水平上升组、中水平上升组和高水平快速上升组;舒张压子队列可分为舒张压低水平下降组和高水平下降组。对收缩压子队列和舒张压子队列分别进行Cox回归分析显示,调整可能的混杂因素(年龄、性别、收缩压、舒张压、吸烟、饮酒、体质量指数、空腹血糖、第1年体检、血脂异常等)后,收缩压子队列中,收缩压高水平快速上升组的冠心病发病风险是低水平上升组的冠心病发病风险的2.23倍(95%CI:1.13~4.40);舒张压子队列中,舒张压高水平下降组的冠心病发病风险是低水平下降组冠心病发病风险的0.96倍(95%CI:0.54~1.71)。进一步调整基线收缩压和舒张压水平后,收缩压子队列中,收缩压高水平快速上升组的冠心病发病风险是低水平上升组的冠心病发病风险的3.19倍(95%CI:1.31~7.80);舒张压子队列中,舒张压高水平下降组的冠心病发病风险是低水平下降组冠心病发病风险的1.04倍(95%CI:0.56~1.93)。而舒张压高水平下降组和低水平下降组组间冠心病发病水平差异无统计学意义(HR=1.03,95%CI:0.56~1.89)。结论血压水平随年龄的变化轨迹与冠心病发生有关,且不受包含基线血压水平在内的其他代谢因素的影响。 展开更多
关键词 血压 冠心病 群组化轨迹模型 COX比例风险模型 队列
Constructing Large Scale Cohort for Clinical Study on Heart Failure with Electronic Health Record in Regional Healthcare Platform:Challenges and Strategies in Data Reuse 预览
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作者 Daowen Liu Liqi Lei +1 位作者 Tong Ruan Ping He 《中国医学科学杂志:英文版》 CAS CSCD 2019年第2期90-102,共13页
Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face ... Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform.In this paper,we propose methodology and process on constructing large scale cohorts which forms the basis of causality and comparative effectiveness relationship in epidemiology.We firstly constructed a Chinese terminology knowledge graph to deal with the diversity of vocabularies on regional platform.Secondly,we built special disease case repositories (i.e.,heart failure repository) that utilize the graph to search the related patients and to normalize the data.Based on the requirements of the clinical research which aimed to explore the effectiveness of taking statin on 180-days readmission in patients with heart failure,we built a large-scale retrospective cohort with 29647 cases of heart failure patients from the heart failure repository.After the propensity score matching,the study group (n=6346) and the control group (n=6346) with parallel clinical characteristics were acquired.Logistic regression analysis showed that taking statins had a negative correlation with 180-days readmission in heart failure patients.This paper presents the workflow and application example of big data mining based on regional EHR data. 展开更多
关键词 electronic health RECORDS CLINICAL terminology knowledge graph CLINICAL special disease case REPOSITORY evaluation of data quality large scale COHORT study
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Association between Chinese Medicine Therapy and Survival Outcomes in Postoperative Patients with NSCLC:A Multicenter,Prospective,Cohort Study
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作者 WANG Xue-qian ZHANG Ying +17 位作者 HOU Wei WANG Ying-tian ZHENG Jia-bin LI Jie LIN Li-zhu JIANG Yi-lan WANG Shen-yu XIE Ying ZHANG Hong-liang SHU Qi-jin LI Ping WANG Wei YOU Jian-liang LI Ge LIU Jie FAN Hui-ting ZHANG Mei-ying LIN Hong-sheng 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第11期812-819,共8页
Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospectiv... Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospective cohort study was conducted in 13 medical centers in China.Patients with stage I,II,or IDA NSCLC who had undergone radical resection and received conventional postoperative treatment according to the National Comprehensive Cancer Network(NCCN)guidelines were recruited.The recruited patients were divided into a CM treatment group and a control group according to their wishes.Patients in the CM treatment group received continuous CM therapy for more than 6 months or until disease progression.Patients in the control group received CM therapy for less than 1 month.Follow-up was 8nducted over 3 years.The primary outcome was DFS,with recurrence/metastasis rates as a secondary outcome.Results:Between May 2013 and August 2016,503 patients were enrolled into the cohort;266 were classified in the CM treatment group and 237 in the control group.Adjusting for covariates,high exposure to CM was associated with better DFS[hazard ratio(HR)=0.417,95%confidential interval(Cl):0.307-0.567)].A longer duration of CM therapy(6-12 months,12-18 months,>24 months)was associated with lower recurrence and metastasis rates(HR=0.225,0.119 and 0.083,respectively).In a subgroup exploratory analysis,CM therapy was also a protective factor of cancer recurrence and metastasis in both stage n-MA(HR=0.50,95%Cl:0.37-0.67)and stage IDA NSCLC postoperative patients(HR=0.48,95%Cl:0.33-0.71),DFS was even longer among CM treatment group patients.Conclusions:Lon ger duration of CM therapy could be 8nsidered a protective factor of cancer recurrence and metastasis.CM treatment is associated with improving survival outcomes of postoperative NSCLC patients in China. 展开更多
关键词 Chinese medicine NON-SMALL cell LUNG cancer POSTOPERATIVE care COHORT study disease-free survival
Association between Pre-pregnancy Body Mass Index and Offspring Neuropsychological Development from 1 to 24 Months of Age: A Birth Cohort Study in China 预览
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作者 CAO Lu Jia LIN Hong Yan +7 位作者 LIANG Xuan CHEN Yong Jie LIU Yu Yan ZHENG Yu Zhi WANG Xin Yan LI Wen YAN Jing HUANG Guo Wei 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第10期730-738,共9页
Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in China.Methods In this birth cohort study, a total of 2,253 mo... Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in China.Methods In this birth cohort study, a total of 2,253 mother-child pairs were enrolled in Tianjin, China,between July 2015 and May 2018. The China Developmental Scale for Children was used to assess developmental quotient(DQ) of children aged from 1 to 24 months.Results Mixed-models analysis revealed significant age × pre-pregnancy BMI interactions for total DQ and five neurobehavioral domains(gross motor, fine motor, adaptive, language, and social;P < 0.001).Age × pre-pregnancy BMI ≥ 25 kg/m^2 was associated with a negative effect on total DQ and five neurobehavioral domains, as compared to pre-pregnancy BMI < 25 kg/m^2(P < 0.01). Multiple comparisons showed pre-pregnancy BMI ≥ 25 kg/m^2 of mothers had a positive effect on child total DQ at the age of 1 month but a negative effect at 24 months(P < 0.05).Conclusions This study supported the age × pre-pregnancy BMI interaction on offspring neuropsychological development. It also revealed a short-term positive impact of high pre-pregnancy BMI on neuropsychological development at 1 month of age, but a long-term negative effect(from 1 to24 months). 展开更多
关键词 Pre-pregnancy BMI Neuropsychological development OFFSPRING The first 1 000 days Birth cohort study
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Anti-hepatitis C virus therapy in chronic kidney disease patients improves long-term renal and patient survivals 预览
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作者 Yi-Chun Chen Chung-Yi Li +1 位作者 Shiang-Jiun Tsai Yen-Chun Chen 《世界临床病例杂志》 2019年第11期1270-1281,共12页
BACKGROUND Hepatitis C virus (HCV) infection is a documented risk factor for chronic kidney disease (CKD) and progression to end-stage renal disease (ESRD). However, to date there are no reports on the long-term hard ... BACKGROUND Hepatitis C virus (HCV) infection is a documented risk factor for chronic kidney disease (CKD) and progression to end-stage renal disease (ESRD). However, to date there are no reports on the long-term hard endpoints (ESRD and death) of anti-HCV therapy [interferon-based therapy (IBT) or new direct-acting antivirals] in CKD patients. Direct-acting antivirals are not available in Taiwan’s singlepayer national health insurance database currently released for research. Therefore, we hypothesized that a retrospective analysis of the long-term outcomes of IBT in CKD patients will serve as a proxy for direct-acting antivirals to increase our understanding of progression to ESRD following HCV infection. AIM To evaluate the long-term outcomes (ESRD and death) of anti-HCV therapy, especially IBT, in HCV-infected patients with stage 1-5 CKD. METHODS We analyzed 93894 Taiwanese adults diagnosed with CKD and without HBV infection. Of these, 4.9% were infected with HCV. Of the 4582 HCV-infected CKD patients, 482 (10.5%) received IBT (treated cohort). They were matched 1:4 with 1928 untreated HCV-infected CKD patients (untreated cohort) by propensity scores and year, which further matched 1:2 by propensity scores with 3856 CKD patients without HCV infection (uninfected cohort). All participants were followed until the occurrence of ESRD, death, or the end of 2012. The association between HCV infection, IBT use, and risks of ESRD and death was analyzed using competing risk analysis. RESULTS Taking the uninfected cohort as a reference, the adjusted hazard ratios for ESRD, after adjusting for competing mortality, were 0.34 (0.14-0.84, P = 0.019) and 1.28 (1.03-1.60, P = 0.029) in the treated and untreated cohorts, respectively. The treated cohort had a 29%(0.54-0.92, P = 0.011) decrease in mortality compared to the untreated cohort, in which the mortality was 31%(1.18-1.45, P < 0.001) higher than in the uninfected cohort. The reduced risks of ESRD (0.14, 0.03–0.58, P = 0.007) and death (0.57, 0.41-0.79, P = 0.001) w 展开更多
关键词 Hepatitis C VIRUS Chronic kidney DISEASE END-STAGE RENAL DISEASE Antihepatitis C VIRUS THERAPY COHORT study
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Survival rate and the determinants of progression from HIV to AIDS and from AIDS to the death in Iran: 1987 to 2016
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作者 Mohammad Mirzaei Maryam Farhadian +3 位作者 Jalal Poorolajal Parvin Afsar Kazerooni Katayoun Tayeri Younes Mohammadi 《亚太热带医药杂志:英文版》 SCIE CAS 2019年第2期72-78,共7页
Objective: To examine the prognostic factors of progression from HIV to AIDS and AIDS to the death in people living with HIV/AIDS in Iran.Methods: In this registry-based retrospective cohort study, we recruited 28 873... Objective: To examine the prognostic factors of progression from HIV to AIDS and AIDS to the death in people living with HIV/AIDS in Iran.Methods: In this registry-based retrospective cohort study, we recruited 28 873 HIV-infected people from 158 Behavioral Diseases Counseling Centers of Iran.Two outcomes of interest included survival rates from HIV diagnosis to AIDS and from AIDS to the death.We used Kaplan-Meier and Cox regression model to investigate survival rate and factors affecting on survival controlling effect of confounding factors.Results: The one, three, five, and ten-year survival rate from HIV to AIDS were 85%, 73%, 61% and 32%, and for AIDS to death were 90%, 81%, 74% and 55%, respectively.Multivariate Cox regression analysis indicated that the risk of progression from AIDS phase toward death in individuals with CD4 less than 200/mm~3, infected with tuberculosis(TB) and not treated by antiretroviral therapy(ART) was 2.17(95% CI: 1.62-2.90), 1.49(95% CI: 1.01-2.20) and 4.88(95% CI: 3.42-6.96) times higher respectively.The risk of progression to AIDS in patients with baseline CD4 less than 200/mm~3 was 2.32(95% CI: 2.14, 2.51) times higher than patients with CD4 > 200/mm~3(P=0.001).On the other hand, tuberculosis increases the risk of death by 49.0%(P=0.04).The hazard ratio of death in patients who did not receive ART was 4.88(95% CI: 3.42, 6.96) times higher than patients who received ART(P<0.001).Conclusion: The early detection of HIV, the screening and treatment of TB and receiving the ART improve the survival of HIV/AIDS patients significantly, and prevent the transmission of HIV to other people. 展开更多
关键词 HIV/AIDS PROGNOSTIC factor SURVIVAL time TUBERCULOSIS COHORT study
金昌队列人群慢性阻塞性肺病及尘肺发病状况研究
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作者 曹家宁 张德生 +11 位作者 黄军军 蒋楠 李海燕 包凯芳 丁婕 陈晓亮 马莉 胡晓斌 李娟生 任晓卫 程宁 白亚娜 《中华劳动卫生职业病杂志》 CAS CSCD 北大核心 2019年第9期650-655,共6页
目的了解金昌队列人群不同作业岗位慢性阻塞性肺病及尘肺的发病状况,探讨慢性阻塞性肺病及尘肺高发病种及高危人群,为降低慢性阻塞性肺病及尘肺提供发病基础数据。方法于2014年1月,以金昌队列随访人群作为研究对象,以甘肃省金昌市某三... 目的了解金昌队列人群不同作业岗位慢性阻塞性肺病及尘肺的发病状况,探讨慢性阻塞性肺病及尘肺高发病种及高危人群,为降低慢性阻塞性肺病及尘肺提供发病基础数据。方法于2014年1月,以金昌队列随访人群作为研究对象,以甘肃省金昌市某三级甲等医院对慢性阻塞性肺病及尘肺的诊断情况作为发病指标。剔除研究对象于2013年前已确诊患慢性阻塞性肺病及尘肺的个案后,共对17 843例随访个案按性别、年龄、作业岗位、吸烟状况分层后进行研究。用χ2检验进行慢性阻塞性肺病及尘肺发生率显著性检验。结果金昌队列人群不同作业岗位慢性阻塞性肺病及尘肺累计总发生率为11.66‰(208/17 843),男性为13.60‰(75/11 102)、女性为8.46‰(51/6 741);病种顺位为:慢性支气管炎(7.06‰,126/17 843)、肺气肿(3.42‰,161/17 843)、尘肺(0.84‰,15/17 843)和其他类型慢性阻塞性肺病(0.34‰,6/17 843);不同作业岗位慢性支气管炎发生率以行政管理岗位为居高(10.45‰,22/2 105),肺气肿男性发生率以生活服务岗位居高(14.34‰,11/767),尘肺男性发生率以开采岗位居高(3.86‰,13/3 369)。不同吸烟状况男性尘肺发生率有差异,差异有统计学意义(P<0.05)。结论金昌队列人群慢性阻塞性肺病及尘肺发病以慢性支气管炎为主,主要影响因素为吸烟及职业暴露。 展开更多
关键词 队列 发生率 作业岗位 慢性阻塞性肺病 尘肺病
Cross-Cultural Study of Historical Effects on Emotional Intelligence Among Young Adults 预览
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作者 Makhinur Mamatova Diane E. Wille 《心理学研究:英文版》 2019年第6期235-242,共8页
This study investigates historical and cultural effects on one component of emotional intelligence,the ability to recognize and report on one’s emotions.This study suggests a novel influence on emotional intelligence... This study investigates historical and cultural effects on one component of emotional intelligence,the ability to recognize and report on one’s emotions.This study suggests a novel influence on emotional intelligence,an individual’s historical context.Samples of young adults,from Kyrgyzstan,former Soviet Republic in Central Asia,and the USA were assessed using the Toronto Alexithymia Scale (TAS-20)(Bagby,Parker,& Taylor,1994) in 2002 and again in 2012,and in 2018.Significant historical cohort effect,significant interaction effect,and gender effects were found. 展开更多
关键词 CROSS-CULTURAL research EMOTIONAL intelligence ALEXITHYMIA young ADULTS COHORT effect
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Design, methodology, and preliminary results of the follow-up of a population-based cohort study in rural area of northern China:Handan Eye Study
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作者 Kai Cao Jie Hao +10 位作者 Ye Zhang Ai-Lian Hu Xiao-Hui Yang Si-Zhen Li Bing-Song Wang Qing Zhang Jian-Ping Hu Cai-Xia Lin Mayinuer Yusufu Ning-Li Wang 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第18期2157-2167,共11页
Background:Handan Eye Study (HES),a large population-based cohort study in rural area of northern China,was one of the few studies focusing on the major eye diseases of rural Chinese population.The aim of this study w... Background:Handan Eye Study (HES),a large population-based cohort study in rural area of northern China,was one of the few studies focusing on the major eye diseases of rural Chinese population.The aim of this study was to introduce the design,methodology and to assess the data quality of the follow-up phase of HES.Methods:All participants were recruited in Yongnian county of Handan city between 2012 and 2013.Main outcomes were measured by visual quality scales and ocular examinations.We performed the Chi-square test to make comparison of categorical data among groups,One-way analysis of variance and Kruskal-Wallis test was applied to make comparison of continuous data among groups,a post-hoc test was done to make further pairwise comparison.Inter-class correlation coefficients (ICCs) and Kappa coefficients were used to evaluate the consistency between different operators.Logistic regression was used to explore the influence factors of death,odds ratio (OR) and 95% confidence interval (CI) were used to estimate the effect size of each influence factor.Results:The follow-up rate was 85.3%.Subjects were classified into three groups:the follow-up group (n =5394),the loss to follow-up group (n =929),and the dead group (n =507),comparison of their baseline information was done.Compared with the other two groups,age of the dead group (66.52 ± 10.31 years) was the oldest (Z =651.293,P < 0.001),male proportion was the highest (59.0 %)(x2 =42.351,P < 0.001),only 65.9 % of the dead finished middle school education (Z =205.354,P < 0.001).The marriage percentage,body mass index (BMI),best-corrected visual acuity (BCVA),and intra-ocular pressure of the dead group was the lowest either.Spherical equivalent error (SER) of the dead group was the highest.Besides,history of smoking,hypertension,diabetes,and heart disease were more common in the dead group.Multivariate analysis showed that age (OR =1.901,95% CI:1.074-1.108),gender (OR =0.317,95% CI:0.224-0.448),and BCVA (OR =0.282,95% CI:0.158-0.503) were associated with death.Whi 展开更多
关键词 COHORT STUDY Rural population METHODOLOGY FOLLOW-UP BIAS
中国私营企业主的社会构成:阶级与同期群差异
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作者 范晓光 吕鹏 亢晓妮 《中国社会科学:英文版》 2019年第1期42-62,共21页
基于中国私营企业调查历年数据,试图回答“私营企业主的社会构成”这一经典命题。经过近40年的发展,私营企业主的总体构成已发生重大变化,市场背景、受过高等教育、非政治党派的构成在上升。通过将私营企业主的职业流动进一步划分成“... 基于中国私营企业调查历年数据,试图回答“私营企业主的社会构成”这一经典命题。经过近40年的发展,私营企业主的总体构成已发生重大变化,市场背景、受过高等教育、非政治党派的构成在上升。通过将私营企业主的职业流动进一步划分成“下海”、“改制”、“跨界”、“跳板”、“草根”等类型,发现大、中、小三种类型的企业主在创业前的职业流动存在显著差异,尤其是大企业主更有可能来自体制内下海或改制,而中小企业主以体制外成长为主。多元回归和系数集束化分析表明,教育程度与政治身份在阶层地位和同期群方面对企业主职业流动产生不同的影响。 展开更多
关键词 私营企业主 职业流动 阶层 同期群
Childhood BMI and Adult Obesity in a Chinese Sample: A 13-Year Follow-up Study 预览
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作者 LIU Dan HAO Yun Xia +9 位作者 ZHAO Ting Zhi SONG Peng Kun ZHAI Yi PANG Shao Jie ZHAO Yan Fang ZHANG Mei WANG Zhuo Qun MI Sheng Quan WANG Yu Ying ZHANG Jian 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第3期162-168,共7页
Objective Obesity is recognized as a significant risk factor for diabetes and hypertension. The present study aimed to examine the associations between adults' obesity risk and childhood and parental obesity. Meth... Objective Obesity is recognized as a significant risk factor for diabetes and hypertension. The present study aimed to examine the associations between adults' obesity risk and childhood and parental obesity. Methods A total of 204 children aged 6-17 years were recruited in 2002 with an average follow-up period of 13.2 years. Height and body weight were measured by trained staffs. Overweight and obesity were defined based on the Chinese standard for children and adults. T-test, analysis of variance, and Chi-square analysis were used for single factor analysis. Multiple linear and logistic regression analyses were used to perform multifactor analysis. Results The percentage of non-obese children who grew up to be non-obese adults was 62.6%, and that of obese children who grew up to be obese adults was 80.0%. There was a significant association between childhood body mass index (BMI) and adulthood BMI with a β regression coefficient of 3.76[95% confidence interval (CI):1.36-6.16], and between childhood obesity and adulthood obesity with an odds ratio of 5.76 (95% CI:1.37-24.34). There was no statistical difference between parental obesity at baseline and children's adulthood obesity, after adjustment of confounders. Male participants and those aged 10.0-13.0 years had a higher risk of adulthood obesity with odds ratios of 2.50 (95% CI:1.12-5.26) and 3.62 (95% CI:1.17-11.24), respectively. Conclusion Childhood obesity is an important predictor of adulthood obesity. 展开更多
关键词 OBESITY Children and adolescents Life COURSE EPIDEMIOLOGY COHORT study China
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上海市嘉定区男男性行为者HIV新发感染及队列保持影响因素研究
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作者 殷方兰 钟培松 +4 位作者 张永 王嘉行 路明 梁冬妮 程华 《中国艾滋病性病》 CAS CSCD 北大核心 2019年第9期947-950,共4页
目的了解上海市嘉定区男男性行为者(MSM)队列保持、艾滋病病毒(HIV)新发感染以及相关影响因素,为开展MSM综合干预提供建议。方法通过自愿咨询检测(VCT)门诊、同伴推动、网络动员、外展干预等方式招募MSM,建立随访队列,并对随访队列数据... 目的了解上海市嘉定区男男性行为者(MSM)队列保持、艾滋病病毒(HIV)新发感染以及相关影响因素,为开展MSM综合干预提供建议。方法通过自愿咨询检测(VCT)门诊、同伴推动、网络动员、外展干预等方式招募MSM,建立随访队列,并对随访队列数据进行统计分析。结果共招募334名MSM,排除HIV阳性39人(11.68%),HIV抗体血清阴性基线队列295人,12个月后随访到149人,队列保持率50.51%。Logistic回归模型分析显示:年龄组[比值比(OR)值为1.32,95%可信区间(CI):1.04~1.68]、知识得分(OR值为1.34,95%CI:1.04~1.72)是队列保持危险因素。总观察时间300.67人年,HIV确证阳转6人,新发感染率为2.00/100人年(95%CI:0.81~4.15/100人年);梅毒快速血浆反应素环状卡片试验(RPR)转阳2人,新发感染率为0.67/100人年(95%CI:0.11~2.20/100人年)。COX回归模型分析显示:过去是否患过性病[风险比(HR)值为14.11,95%CI:2.37~84.16]是艾滋病新发感染的危险因素。结论 MSM艾滋病患病率、新发感染率较高,患有性病的MSM容易新发感染艾滋病病毒;MSM队列保持困难,低知识水平、低年龄MSM更容易失访。 展开更多
关键词 男男性行为者 新发感染 队列
The effect of long-term traditional Chinese medicine treatment on disease-free survival of postoperative stage I-III lung cancer patients:a retrospective cohort study 预览
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作者 Su-Tong Liu Su-Fang Zhang +6 位作者 Kai-Qi Su Ying-Bin Luo Zhi-Hong Fang Yuan Fang Jing Xu Jian-Chun Wu Yan Li 《TMR传统医学研究》 2019年第2期91-98,共8页
Objective:Traditional Chinese medicine(TCM)has been extensively used as one of popular alternative therapies for several cancers.However,it remains unclear whether TCM treatment is associated with longer survival in l... Objective:Traditional Chinese medicine(TCM)has been extensively used as one of popular alternative therapies for several cancers.However,it remains unclear whether TCM treatment is associated with longer survival in lung cancer patients.In this study,we explored the effect of long-term TCM treatment on patients with different stages of lung cancer.Methods:All information of lung cancer patients with stage I-III disease from January 2007 to September 2015 was collected for this retrospective cohort study.Those who were treated with TCM after surgery were divided into TCM group and the others were into the non-TCM group(control group).All patients were regularly followed up by clinic appointment or phone,and all survival data were collected from databases after the last follow-up in October 2017.Results:A total of 575 patients were included in this study,with 299 patients in the TCM group and 276 in the control group.For all patients,5-year disease-free survival(DFS)was 62.2% in TCM group and 42.1% in the control group,and 6-year DFSs were 51.8% and 35.4%,respectively(HR=0.51,95% CI:0.40 to 0.66,log-rank P≤0.001).For patients with stage I,5-year DFSs were 83.7%(TCM group)and 57.5%(control group)and 6-year DFSs were 73.7% and 51.9%,respectively(HR=0.30,95% CI:0.18 to 0.50,log-rank P≤0.001).For patients with stage II in the TCM group and the control group,5-year DFSs were 59.4% and 17.6% and 6-year DFSs were 44.7% and 17.6%,respectively(HR=0.31,95% CI:0.19 to 0.52,log-rank P≤0.001),and for patients with stage III,5-year and 6-year DFSs in the TCM group were 18.7% and 12.5% compared with 28.4% and 20.3% in the control group(HR=1.06,95% CI:0.72 to 1.56,log-rank P=0.76).Conclusions:This study demonstrated that long-term TCM treatment as an adjuvant therapy is able to improve the DFS of postoperative stage I-III lung cancer patients,especially in patients with stage I and II disease.However,these observational findings need being validated by large sample randomized controlled trials. 展开更多
关键词 TRADITIONAL Chinese medicine LUNG cancer Disease-free survival RETROSPECTIVE STUDY COHORT STUDY
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新型冠状病毒肺炎防控与诊疗专栏