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THE EFFECTS OF COMBINING APPLICATION OF DIAGNOSIS AND TREATMENT TECHNOLOGIES OF ERP AND PSYCHIC REHABILITATION INTERVENTION ON REHABILITATION OF SCHIZOPHRENIA 预览
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作者 Song Lisheng Zhang Chen +15 位作者 Chen Meijuan Zhang Yi Li Xiaoping Zhao Wenqing Yang Xujiao Huang Xinrui Lin Xiaodong Chen Ce Wang Xiwu Wu Rongqin Xu Lu Tang Jialin Wang Zuowei Zhan Guilai Zhang Zhanxing He Qiuhao 《现代电生理学杂志》 2019年第B03期19-27,共9页
Objective:To explore the effects of combining application of diagnosis and treatment technologies of Event Related Potentials(ERP)and Psychic Rehabilitation Intervention(PRI)on rehabilitation of schizophrenia.Methods:... Objective:To explore the effects of combining application of diagnosis and treatment technologies of Event Related Potentials(ERP)and Psychic Rehabilitation Intervention(PRI)on rehabilitation of schizophrenia.Methods:PRI and ERP were used in schizophrenia rehabilitation in this research.232 patients were divided into study group(SG)and control group(CG),and the rehabilitation effects were compared.Results:(1)After the implementation of the PRI,more score of the Brief Psychiatric Rating Scale(BPRS)was reduced on SG than the score on CG;more decreased scores of insight and on Social Disability Screening Schedule(SDSS),and more increased scores of treatment compliance questionnaire scores were observed on SG,comparing with CG(P<0.05 or 0.01).(2)After the implementation of the PRI,more decreased factor scores of Symptom Checklist 90 were observed on SG patients family members(P<0.05 or 0.01).(3)PRI significantly improved the patients’social functions,family members’relationship and prevented the recurrence of schizophrenia.(4)Improved P2,P3 amplitudes were also detected on SG compared with CG(P<0.05).Conclusions:(1)PRI interventions may improve schizophrenia patients’social function.(2)ERP may be used to evaluate the schizophrenia patients’rehabilitation,and is worth being popularized. 展开更多
关键词 Event Related Potential Cognitive function SCHIZOPHRENIA Rehablitation Cognitive function Multple-center Perspective cohort study
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Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease 预览
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作者 Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns +6 位作者 Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1626-1634,共9页
Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived e... Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. 展开更多
关键词 Alzheimer’s DISEASE neurodegenerative DISEASE COGNITIVE impairment memory Alzheimer’s DISEASE MOUSE model mesenchymal stem cell EXOSOMES NEUROGENESIS COGNITIVE improvement cell-free therapy neural regeneration
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Assessment of Cognitive skills via Human-robot Interaction and Cloud Computing
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作者 Alessandro Di Nuovo Simone Varrasi +3 位作者 Alexandr Lucas Daniela Conti John McNamara Alessandro Soranzo 《仿生工程学报:英文版》 SCIE EI CSCD 2019年第3期526-539,共14页
Technological advances are increasing the range of applications for artificial intelligence, especially through its embodiment within humanoid robotics platforms. This promotes the development of novel systems for aut... Technological advances are increasing the range of applications for artificial intelligence, especially through its embodiment within humanoid robotics platforms. This promotes the development of novel systems for automated screening of neurological conditions to assist the clinical practitioners in the detection of early signs of mild cognitive impairments. This article presents the implementation and the experimental validation of the first robotic system for cognitive assessment, based on one of the most popular platforms for social robotics, Softbank "Pepper", which administers and records a set of multi-modal interactive tasks to engage the user cognitive abilities. The robot intelligence is programmed using the state-of-the-art IBM Watson AI Cloud services, which provide the necessary capabilities for improving the social interaction and scoring the tests. The system has been tested by healthy adults (N= 35) and we found a significant correlation between the automated scoring and one of the most widely used Paper-and-Pencil tests. We conclude that the system can be considered as a screening instrument for cognitive assessment. 展开更多
关键词 socially assistive ROBOTICS brief COGNITIVE testing human-robot interaction NEUROLOGICAL screening CLOUD COMPUTING
Long-term adenosine A1 receptor activation-induced sortilin expression promotesα-synuclein upregulation in dopaminergic neurons 预览
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作者 Yun-Cheng Lv An-Bo Gao +7 位作者 Jing Yang Li-Yuan Zhong Bo Jia Shu-Hui Ouyang Le Gui Tian-Hong Peng Sha Sun Francisco S.Cayabyab 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期712-723,共12页
Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.However,the pathogenesis underlying long-term adenosine A1 receptor... Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.However,the pathogenesis underlying long-term adenosine A1 receptor activation-induced neurodegeneration remains unclear.In this study,rats were intraperitoneally injected with 5 mg/kg of the adenosine A1 receptor agonist N6-cyclopentyladenosine(CPA)for five weeks.The mobility of rats was evaluated by forced swimming test,while their cognitive capabilities were evaluated by Y-maze test.Expression of sortilin,α-synuclein,p-JUN,and c-JUN proteins in the substantia nigra were detected by western blot analysis.In addition,immunofluorescence staining of sortilin andα-synuclein was performed to detect expression in the substantia nigra.The results showed that,compared with adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine(5 mg/kg)+CPA co-treated rats,motor and memory abilities were reduced,surface expression of sortin andα-synuclein in dopaminergic neurons was reduced,and total sortilin and totalα-synuclein were increased in CPA-treated rats.MN9D cells were incubated with 500 nM CPA alone or in combination with 10μM SP600125(JNK inhibitor)for 48 hours.Quantitative real-time polymerase chain reaction analysis of sortilin andα-synuclein mRNA levels in MN9D cells revealed upregulated sortilin expression in MN9D cells cultured with CPA alone,but the combination of CPA and SP600125 could inhibit this expression.Predictions made using Jasper,PROMO,and Alibaba online databases identified a highly conserved sequence in the sortilin promoter that was predicted to bind JUN in both humans and rodents.A luciferase reporter assay of sortilin promoter plasmid-transfected HEK293T cells confirmed this prediction.After sortilin expression was inhibited by sh-SORT1,expression of p-JUN and c-JUN was detected by western blot analysis.Long-term adenosine A1 receptor activation levels upregulatedα-synuclein expression at the post-transcriptional level by affecting sort 展开更多
关键词 cognitive dysfunction dopaminergic neuron DYSKINESIA JNK/c-JUN pathway long-term adenosine A1 receptor activation neural regeneration neurodegenerative diseases SORTILIN Α-SYNUCLEIN
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Multi-Strategy Dynamic Spectrum Access in Cognitive Radio Networks:Modeling,Analysis and Optimization 预览
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作者 Yi Yang Qinyu Zhang +3 位作者 Ye Wang Takahiro Emoto Masatake Akutagawa Shinsuke Konaka 《中国通信:英文版》 SCIE CSCD 2019年第3期103-121,共19页
Dynamic spectrum access(DSA)based on cognitive radios(CR)technique is an effective approach to address the“spectrum scarcity”issue.However,traditional CR-enabled DSA system employs only single DSA strategy,which mig... Dynamic spectrum access(DSA)based on cognitive radios(CR)technique is an effective approach to address the“spectrum scarcity”issue.However,traditional CR-enabled DSA system employs only single DSA strategy,which might not be suited to the dynamic network environment.In this paper,we propose a multi-strategy DSA(MS-DSA)system,where the primary and the secondary system share spectrum resources with multiple DSA strategies simultaneously.To analyze the performance of the proposed MS-DSA system,we model it as a continuous-time Markov chain(CTMC)and derive the expressions to compute the corresponding performance metrics.Based on this,we define a utility function involving the concerns of effective throughput,interference quantity on primary users,and spectrum leasing cost.Two optimization schemes,named as spectrum allocation and false alarm probability selection,are proposed to maximize the utility function.Finally,numerical simulations are provided to validate our analysis and demonstrate that the performance can be significantly improved caused by virtues of the proposed MS-DSA system. 展开更多
关键词 COGNITIVE RADIO networks dynamic SPECTRUM access multi-strategy performance analysis optimization
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阿尔茨海默病与路易体痴呆患者随访1年情况分析
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作者 甘景环 刘帅 +4 位作者 赵玉瑾 胡文政 李张龙 石志鸿 纪勇 《阿尔茨海默病及相关病》 2019年第2期333-338,共6页
目的:通过比较阿尔茨海默病和路易体痴呆患者在初次就诊及随访(12±2)月后的认知及精神变化情况,探索疾病的变化规律,为促进痴呆的早期诊断,延缓病程进展提供参考。方法:选取天津市环湖医院认知障碍门诊于2011年3月—2018年9月期间... 目的:通过比较阿尔茨海默病和路易体痴呆患者在初次就诊及随访(12±2)月后的认知及精神变化情况,探索疾病的变化规律,为促进痴呆的早期诊断,延缓病程进展提供参考。方法:选取天津市环湖医院认知障碍门诊于2011年3月—2018年9月期间就诊的483例AD和117例DLB患者,对其分别在初诊和第(12±2)月进行2次随访,动态观察患者认知情况变化。结果:AD组平均初诊年龄为65.13 (±9.34)岁,DLB组的初诊年龄为69.09 (±8.95)岁;两组在教育程度、主诉记忆减退时间上存在统计学差异,而在婚姻状况、居住状况等方面无统计学差异。两组初诊时在幻觉、妄想、睡眠情况等方面,DLB患者多于AD患者。在完成随访的患者中,AD组有121人,DLB组有28人。二者的随访脱落情况与患者的教育程度和疾病严重程度相关。在AD组中,其神经心理测试评分变化情况为:MMSE平均下降1.54分,MoCA平均下降0.85分,ADL平均升高2.49分;DLB组中,其神经心理测试评分变化情况为:MMSE平均下降0.625分,MoCA平均下降0.61分,ADL平均升高4.54分。结论:AD患者与DLB患者的初诊年龄、就诊前病程,随访1年后的神经心理量表评估对二者有鉴别诊断意义。 展开更多
关键词 阿尔茨海默病 路易体痴呆 随访 认知
Sex differences in color discrimination and serial reversal learning in mollies and guppies
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作者 Theodora FUSS Klaudia WITTE 《动物学报:英文版》 SCIE CAS CSCD 2019年第3期323-332,共10页
Behavioral flexibility provides an individual with the ability to adapt its behavior in response to environmental changes. Studies on mammals, birds, and teleosts indicate greater behavioral flexibility in females. Co... Behavioral flexibility provides an individual with the ability to adapt its behavior in response to environmental changes. Studies on mammals, birds, and teleosts indicate greater behavioral flexibility in females. Conversely, males appear to exhibit greater behavioral persistenee. We, therefore, investigated sex differences in behavioral flexibility in 2 closely related molly species (Poecilia latipinna, P. mexicana) and their more distant relative, the guppy P. reticulata by comparing male and female individuals in a serial, visual reversal learning task. Fish were first trained in color discrimination, which was quickly learned by all females (guppies and mollies) and all molly males alike. Despite continued training over more than 72 sessions, male guppies did not learn the general test procedure and were, therefore, excluded from further testing. Once the reward contingency was reversed serially, molly males of both species performed considerably better by inhibiting their previous response and reached the learning criterion sign讦icantly faster than their respective con specific females. Moreover, Atlantic molly males clearly outperformed all other individuals (males and females) and some of them even reached the level of 1-trial learning. Thus, the apparently un iversal pattern of higher female behavioral flexibility seems to be in verted in the 2 examined molly species, although the evolutionary account of this pattern remains highly speculative. These findings were complemented by the observed lower neophobia of female sailfin mollies compared with their male con specifics. This sex differe nee was not observed in Atlantic mollies that were observed to be sigrdficantly less distressed in a novel situation than their consexuals. Hypothetically, sex differences in behavioral flexibility can possibly be explained in terms of the different roles that males and females play in mating competition, mate choice, and reproduction or, more gen erally, in complex social in teractio ns. Each of these characteristic 展开更多
关键词 behavioural and cognitive flexibility colour discrimination NEOPHOBIA SERIAL reversal learning/Poecilia MEXICANA and POECILIA latipinna POECILIA RETICULATA
Pharmacological characterization of JWX-A0108 as a novel type Ⅰ positive allosteric modulator of a7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model
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作者 Li-lan Sun Tao-yi Yang +8 位作者 Ning-ning Wei Wei Lu Wen-xuan Jiao Qi-qi Zhou Yong-zhen Miao Qin Gao Xin-tong Wang Qi Sun KeWei Wang 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第6期737-745,共9页
The a7 nicotinic acetylcholine receptor (a7 nAChR) is a ligand-gated Ca^2+-permeable homopentameric ion channel implicated in cognition and neuropsychiatric disorders. Pharmacological enhancement of a7 nAChR function ... The a7 nicotinic acetylcholine receptor (a7 nAChR) is a ligand-gated Ca^2+-permeable homopentameric ion channel implicated in cognition and neuropsychiatric disorders. Pharmacological enhancement of a7 nAChR function has been suggested for improvement of cognitive deficits. In the present study, we characterized a thiazolyl heterocyclic derivative, 6-(2-chloro-6- methylphenyl)-2-((3-fluoro-4-methylphenyl)amino)thiazolo[4,5-cflpyrimiclin-7(6H)-one (JWX-A0108), as a novel type I a7 nAChR positive allosteric modulator (PAM), and evaluated its ability to reverse auditory gating and spatial working memory deficits in mice. In Xenopus oocytes expressing human nAChR channels, application of JWX-A0108 seleaively enhanced a7 nAChR-mediated inward current in the presence of the agonist ACh (EC50 value = 4.35 ±0.12 pM). In hippocampal slices, co-application of ACh and JWXA0108 (10 pM for each) markedly increased both the frequency and amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs) recorded in pyramidal neurons, but JWX-A0108 did not affect GABA-induced current in oocytes expressing human GABAa receptor aip3y2 and a5(33Y2 subtypes. In mice with MK-801-induced deficits in auditory gating, administration of JWX-A0108 (1, 3, and 10 mg/kg, i.p.) dose-dependently attenuates MK-801-induced auditory gating deficits in five prepulse intensities (72, 76, 80,84, and 88 dB). Furthermore, administration of JWX-A0108 (0.03, 0.1, or 0.3 mg/kg, i.p.) significantly reversed MK-801-induced impaired spatial working memory in mice. Our results demonstrate that JWX-A0108 is a novel type Ⅰ PAM of a7 nAChR, which may be beneficial for improvement of cognitive deficits commonly found in neuropsychiatric disorders such as schizophrenia and Alzheimer's disease. 展开更多
关键词 a7 NACHR positive ALLOSTERIC modulator thiazolyl heterocyclic derivative JWX-A0108 ELECTROPHYSIOLOGY PREPULSE inhibition of ACOUSTIC STARTLE spatial working memory cognitive deficits
红景天苷衍生物对抗抑郁及促学习记忆作用的影响
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作者 李云飞 张瑱 许忻 《世界临床药物》 CAS 2019年第7期479-485,共7页
目的通过大、小鼠体内药动学研究,寻找成药性较好的红景天苷衍生物,并采用动物体内药效模型初步评价该化合物改善学习记忆及抗抑郁的作用。方法设计并合成了一系列红景天苷酰胺衍生物(5a~5e),通过大鼠体内药代动力学研究,找到入脑迅速... 目的通过大、小鼠体内药动学研究,寻找成药性较好的红景天苷衍生物,并采用动物体内药效模型初步评价该化合物改善学习记忆及抗抑郁的作用。方法设计并合成了一系列红景天苷酰胺衍生物(5a~5e),通过大鼠体内药代动力学研究,找到入脑迅速目标化合物(5c),后续以东莨菪碱造成大鼠记忆获得障碍模型,研究不同剂量5c(20、5、1.25 mg/kg)和红景天苷(20、5、1.25 mg/kg)对该模型大鼠学习记忆改善作用;以小鼠悬尾实验中小鼠不动时间,研究不同剂量5c(50、25、12.5 mg/kg)及红景天苷(25 mg/kg)的抗抑郁作用。结果大鼠药代动力学的成药性评价显示,单次口服给予25 mg/kg 5c后,约1.4 h达峰,生物利用度为33.3%(优于红景天苷21.8%),口服吸收后可入脑,脑/血组织中的浓度为比为2.5。在大鼠记忆获得障碍模型Morris水迷宫撤台实验测试中,5c高剂量组(20 mg/kg)及盐酸多奈哌齐组大鼠第一次上台潜伏期及第一次穿台路程较模型对照组缩短,差异具有统计学意义(P <0.05)。大鼠脑部SOD活性测定结果显示,5c高剂量组(20 mg/kg)大鼠脑部SOD活性高于空白对照组,差异具有统计学意义(P <0.05),在小鼠悬尾实验中,在给药2 h的测试时间点,5c高剂量组小鼠悬尾不动时间较空白对照组缩短,差异具有统计学意义(P <0.05)。结论通过对红景天苷进行结构改造,得到了具有良好透过血脑屏障的能力红景天苷衍生物5c,体内药效学评价结果显示:该化合物具有抗抑郁及改善学习记忆的作用,且效果优于红景天苷。 展开更多
关键词 红景天苷衍生物 学习记忆 抑郁
Inhibition ofα5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats 预览
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作者 Zi-Fang Zhao Lei Du +4 位作者 Teng Gao Lin Bao Yuan Luo Yi-Qing Yin Yong-An Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第6期1029-1036,共8页
Theα5 subunit-containing gamma-amino butyric acid type A receptors(α5 GABAARs)are a distinct subpopulation that are specifically distributed in the mammalian hippocampus and also mediate tonic inhibitory currents in... Theα5 subunit-containing gamma-amino butyric acid type A receptors(α5 GABAARs)are a distinct subpopulation that are specifically distributed in the mammalian hippocampus and also mediate tonic inhibitory currents in hippocampal neurons.These tonic currents can be enhanced by low-dose isoflurane,which is associated with learning and memory impairment.Inverse agonists ofα5 GABAARs,such as L-655,708,are able to reverse the short-term memory deficit caused by low-dose isoflurane in young animals.However,whether these negative allosteric modulators have the same effects on aged rats remains unclear.In the present study,we mainly investigated the effects of L-655,708 on low-dose(1.3%)isoflurane-induced learning and memory impairment in elderly rats.Young(3-month-old)and aged(24-month-old)Wistar rats were randomly assigned to receive L-655,708 0.5 hour before or 23.5 hours after 1.3%isoflurane anesthesia.The Morris Water Maze tests demonstrated that L-655,708 injected before or after anesthesia could reverse the memory deficit in young rats.But in aged rats,application of L-655,708 only before anesthesia showed similar effects.Reverse transcription-polymerase chain reaction showed that low-dose isoflurane decreased the mRNA expression ofα5 GABAARs in aging hippocampal neurons but increased that in young animals.These findings indicate that L-655,708 prevented but could not reverse 1.3%isoflurane-induced spatial learning and memory impairment in aged Wistar rats.All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Academy of Military Medical Science of China(approval No.NBCDSER-IACUC-2015128)in December 2015. 展开更多
关键词 ISOFLURANE postoperative cognitive dysfunction hippocampus inverse AGONIST α5 GABAA receptors L-655 708 aged MORRIS Water MAZE memory impairment neural regeneration
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大型体育赛事承办中的城市生态风险识别及防范策略研究——基于不同利益相关者的视角 预览
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作者 梁波 《天津体育学院学报》 CAS CSSCI 北大核心 2019年第5期425-431,446,共8页
采用文献资料、数理统计、逻辑分析等方法,依据利益相关者理论,对大型体育赛事诱发的生态风险和不同利益相关者对生态风险认知现状进行调查。认为,大型体育赛事承办诱发的生态风险主要分为城市生态空间占用性风险、资源能源无序利用过... 采用文献资料、数理统计、逻辑分析等方法,依据利益相关者理论,对大型体育赛事诱发的生态风险和不同利益相关者对生态风险认知现状进行调查。认为,大型体育赛事承办诱发的生态风险主要分为城市生态空间占用性风险、资源能源无序利用过度消耗的风险、环境污染问题集中爆发的风险、生态失衡引发的风险。不同利益相关者生态风险的认知现状调查分析表明,共同点是利益相关者群体对环境污染问题集中爆发的风险变量提及数量最多,不同点是城市居民关注身体健康,经济活动者则关注的是国家政策的制定与实施。完善的风险防范政策、减少环境污染、加强企业环保治理、适当控制人口规模是城市生态系统稳定的核心要素,核心要素管理情景模拟结果显示,能有效提高赛事举办城市生态系统稳定性。结合生态系统管理情景模拟结果和区域生态风险管理理论,构建基于不同利益相关者视角下大型体育赛事承办中的城市生态风险防范行动者网络,最终实现赛事举办城市生态环境的可持续发展。 展开更多
关键词 大型体育赛事 生态风险 利益相关者 认知 风险规避
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认知视角下浙江聋人地名手语造词策略调查 预览
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作者 张帆 卢苇 《北京联合大学学报》 CAS 2019年第2期71-79,共9页
以浙江地名手语为调查对象,通过调查、描述和分析,运用定性和定量相结合的方法,对浙江地名手语的命名策略、认知机制和语用效果进行研究。研究发现,浙江聋人地名手语造词策略主要有两类:一是借用汉语地名,用仿字、书空、仿译、指拼等方... 以浙江地名手语为调查对象,通过调查、描述和分析,运用定性和定量相结合的方法,对浙江地名手语的命名策略、认知机制和语用效果进行研究。研究发现,浙江聋人地名手语造词策略主要有两类:一是借用汉语地名,用仿字、书空、仿译、指拼等方式构成手语词;二是运用“转喻”方式,创造约定俗成的自源性地名手势符号。从认知心理看,转喻是聋人手语基本的意义拓展方式,聋人通过转喻完成地名手语造词的经济性、形象性与理据性表达。转喻机制需要语境的共同参与才能发挥作用,两者合力产生具体形象、通俗易懂、一看便知的语用效果。 展开更多
关键词 地名手语 造词策略 转喻 认知 语用
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The Cognitive Function of Implicature 预览
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作者 崔宁宁 《校园英语》 2019年第18期190-191,共2页
CP is one of the major theories in pr agmatics,it can make a conversation going smoothly,and it can also make a discourse coherent,which is the function of CP.However,with the development of the cognitive linguistics,... CP is one of the major theories in pr agmatics,it can make a conversation going smoothly,and it can also make a discourse coherent,which is the function of CP.However,with the development of the cognitive linguistics,we can use the theory of cognitive linguistics to explain the function of CP.In this thesis,we will talk about the cognitive function of Grice’s Cooperative Principle and its Implicature. 展开更多
关键词 CP IMPLICATURE COGNITIVE LINGUISTICS ICM
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New nomenclature of peri-operative cognitive impairments: possible impacts on further practice and research
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作者 Yi ZOU Liu-Jia-Zi Shao Fu-Shan Xue 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第15期1859-1861,共3页
Peri-operative neurocognitive disorders (PND) is a new term recommended by an international,multidisciplinary group named as Nomenclature Consensus Working Group including experts from multiple disciplines such as ane... Peri-operative neurocognitive disorders (PND) is a new term recommended by an international,multidisciplinary group named as Nomenclature Consensus Working Group including experts from multiple disciplines such as anesthesiology,neurology,geriatrics,psychiatry,neuropsychology,surgery,and psychology.It is a comprehensive term for cognitive impairments identified in the perioperative period.The recommendation of this new nomenclature has been published in several influential journals simultaneously in November 2018.[1-6] It is a tremendous change in the field of peri-operative cognitive impairments.Therefore,it is necessary to know the reasons and purposes of this new nomenclature,differences between old and new nomenclatures,and the possible impacts of new nomenclature on clinical and basic researches of peri-operative cognitive impairments in the future. 展开更多
关键词 COGNITIVE IMPAIRMENTS PRACTICE RESEARCH
NMDA Receptor Antagonist MK801 Protects Against 1-Bromopropane-Induced Cognitive Dysfunction
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作者 Lin Xu Xiaofei Qiu +2 位作者 Shuo Wang Qingshan Wang Xiu-Lan Zhao 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第2期347-361,共15页
Occupational exposure to 1-bromopropane(1-BP) induces learning and memory deficits. However, no therapeutic strategies are currently available. Accumulating evidence has suggested that N-methyl-D-aspartate receptors(N... Occupational exposure to 1-bromopropane(1-BP) induces learning and memory deficits. However, no therapeutic strategies are currently available. Accumulating evidence has suggested that N-methyl-D-aspartate receptors(NMDARs) and neuroinflammation are involved in the cognitive impairments in neurodegenerative diseases. In this study we aimed to investigate whether the noncompetitive NMDAR antagonist MK801 protects against 1-BPinduced cognitive dysfunction. Male Wistar rats were administered with MK801(0.1 mg/kg) prior to 1-BP intoxication(800 mg/kg). Their cognitive performance was evaluated by the Morris water maze test. The brains of rats were dissected for biochemical, neuropathological,and immunological analyses. We found that the spatial learning and memory were significantly impaired in the1-BP group, and this was associated with neurodegeneration in both the hippocampus(especially CA1 and CA3)and cortex. Besides, the protein levels of phosphorylated NMDARs were increased after 1-BP exposure. MK801 ameliorated the 1-BP-induced cognitive impairments and degeneration of neurons in the hippocampus and cortex.Mechanistically, MK801 abrogated the 1-BP-induced disruption of excitatory and inhibitory amino-acid balance and NMDAR abnormalities. Subsequently, MK801 inhibited the microglial activation and release of pro-inflammatory cytokines in 1-BP-treated rats. Our findings, for the first time, revealed that MK801 protected against 1-BP-induced cognitive dysfunction by ameliorating NMDAR function and blocking microglial activation, which might provide a potential target for the treatment of 1-BP poisoning. 展开更多
关键词 1-BROMOPROPANE Cognitive DYSFUNCTION MK801 N-METHYL-D-ASPARTATE receptors MICROGLIA NLRP3 INFLAMMASOME
Humorous Communication and Comprehension:Manipulation and Epistemic Vigilance 预览
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作者 LI Hai-hui 《文学与艺术研究:英文版》 2019年第7期691-701,共11页
This paper takes an integrative approach to the communication and comprehension of humor from the perspectives of the humorist’s manipulation and the recipient’s vigilance informed by relevance theory.It is proposed... This paper takes an integrative approach to the communication and comprehension of humor from the perspectives of the humorist’s manipulation and the recipient’s vigilance informed by relevance theory.It is proposed that,in order to communicate humor,the humorist manipulates the recipient’s expectation of relevance in the setup and in the punchline in two different but related ways:misleading and guiding.It is also proposed that,in order to comprehend and appreciate humor,the recipient exercises vigilance against his/her own shallow processing in the setup and exercises vigilance for special cognitive effects in the punchline.On this approach,humorous communication and comprehension is viewed as an interaction between manipulation and epistemic vigilance.Strategies of manipulation and vigilance are described,and some essential issues arising from the relevance-theoretic approach to humor are reconsidered with some implications drawn.This paper contributes to enhancing the explanatory power of relevance theory for the communication and comprehension of humor. 展开更多
关键词 MANIPULATION EPISTEMIC VIGILANCE strategy special cognitive effect HUMOR
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Cooperative Spectrum Sensing in Cognitive Radio Using Bayesian Updating with Multiple Observations 预览
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作者 Yung-Fa Huang Jyu-Wei Wang 《电子科技学刊:英文版》 CAS CSCD 2019年第3期252-259,共8页
We study cooperative spectrum sensing in cognitive radio (CR) networks using the hidden Markov model (HMM) for opportunistic spectrum access (OSA). We assume that the primary channel operates in a time division multip... We study cooperative spectrum sensing in cognitive radio (CR) networks using the hidden Markov model (HMM) for opportunistic spectrum access (OSA). We assume that the primary channel operates in a time division multiple address (TDMA) manner. Thus, spectrum sensing is operating in a slot-by-slot basis. In contrast to the conventional Bayesian updating using only one observation, in this work, we propose to perform the update in a concatenated fashion with all the observations available from the secondary users (SUs). In the proposed scheme, a predefined threshold on the belief is used for determining the channel activity. With the threshold, the proposed scheme is more flexible in the system operation than the simple majority vote scheme, in which no such threshold is available. We compare, by simulations, the performance of the proposed concatenated update scheme with that of the majority vote scheme and show that the probabilities of correctly detecting a busy state and an idle state are about 1 as the number of SUs is as large as 15, so the effects of the further increase in the number of SUs are limited. 展开更多
关键词 BAYESIAN updating COGNITIVE radio(CR) COOPERATIVE sensing hidden MARKOV model(HMM)
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Study of brain morphology change in Alzheimer’s disease and amnestic mild cognitive impairment compared with normal controls 预览
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作者 Huanqing Yang Hua Xu +10 位作者 Qingfeng Li Yan Jin Weixiong Jiang Jinghua Wang Yina Wu Wei Li Cece Yang Xia Li Shifu Xiao Feng Shi Tao Wang 《综合精神医学(英文)》 CSCD 2019年第2期75-83,共9页
Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer&#... Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer's disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic. Aims The purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC). Methods 20 AD patients, 21 aMCIs and 25 NC were recruited in the study. FreeSurfer software was used to calculate cortical thickness and surface area among groups. Results The patients with AD had less cortical thickness both in the left and right hemisphere in 17 of the 36 brain regions examined than the patients with aMCI or NC. The patients with AD also had smaller cerebral surface area both in the left and right hemisphere in 3 of the 36 brain regions examined than the patients with aMCI or NC. Compared with the NC, the patients with aMCI only had slight atrophy in the inferior parietal lobe of the left hemisphere, and no significant difference was found. Conclusion AD, as well as aMCI (to a lesser extent), is associated with reduced cortical thickness and surface area in a few brain regions associated with cognitive impairment. These results suggest that cortical thickness and surface area could be used for early detection of AD. 展开更多
关键词 BRAIN morphology CHANGE amnestic MILD COGNITIVE IMPAIRMENT compared aMCI NC
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Paired associative stimulation improves synaptic plasticity and functional outcomes after cerebral ischemia 预览
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作者 Yan Hu Tie-Cheng Guo +2 位作者 Xiang-Yu Zhang Jun Tian Yin-Shan Lu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1968-1976,共9页
Paired associative stimulation is a relatively new non-invasive brain stimulation technique that combines transcranial magnetic stimulation and peripheral nerve stimulation. The effects of paired associative stimulati... Paired associative stimulation is a relatively new non-invasive brain stimulation technique that combines transcranial magnetic stimulation and peripheral nerve stimulation. The effects of paired associative stimulation on the excitability of the cerebral cortex can vary according to the time interval between the transcranial magnetic stimulation and peripheral nerve stimulation. We established a model of cerebral ischemia in rats via transient middle cerebral artery occlusion. We administered paired associative stimulation with a frequency of 0.05 Hz 90 times over 4 weeks. We then evaluated spatial learning and memory using the Morris water maze. Changes in the cerebral ultra-structure and synaptic plasticity were assessed via transmission electron microscopy and a 64-channel multi-electrode array. We measured mRNA and protein expression levels of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor 1 in the hippocampus using a real-time polymerase chain reaction and western blot assay. Paired associative stimulation treatment significantly improved learning and memory in rats subjected to cerebral ischemia. The ultra-structures of synapses in the CA1 area of the hippocampus in rats subjected to cerebral ischemia were restored by paired associative stimulation. Long-term potentiation at synapses in the CA3 and CA1 regions of the hippocampus was enhanced as well. The protein and mRNA expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor 1 increased after paired associative stimulation treatment. These data indicate that paired associative stimulation can protect cog-nition after cerebral ischemia. The observed effect may be mediated by increases in the mRNA and protein expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor 1, and by enhanced synaptic plasticity in the CA1 area of the hippocampus. The animal experiments were approved by the Animal Ethics Committee of Tongji Medical College, Huazhong University of Science & Technology, China(appr 展开更多
关键词 cerebral ischemia paired ASSOCIATIVE stimulation cognitive function long-term POTENTIATION SYNAPTIC plasticity Morris water maze SYNAPTIC structure N-methyl-D-aspartic acid receptor BRAIN-DERIVED NEUROTROPHIC factor MULTI-ELECTRODE array neural regeneration
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Neuropsychological features in post-stroke cognitive impairment with no dementia patients with different Traditional Chinese Medicine syndromes
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作者 Ma Jie Wang Yu +3 位作者 Zhang Yunyun Guo Qihao Zhen Xiaomin Shi Moyi 《中医杂志:英文版》 SCIE CAS CSCD 2019年第1期97-102,共6页
OBJECTIVE: To investigate neuropsychological features of post-stroke cognitive impairment with no dementia(PSCIND) patients with different Traditional Chinese Medicine(TCM) syndromes.METHODS: We recruited 50 patients ... OBJECTIVE: To investigate neuropsychological features of post-stroke cognitive impairment with no dementia(PSCIND) patients with different Traditional Chinese Medicine(TCM) syndromes.METHODS: We recruited 50 patients with PSCIND between April 2012 and March 2013. Patients were divided into different groups according to TCM classifications. Patients were assessed using neuropsychological tests, including cognitive screening(mini-mental state examination), memory testing (auditory verbal learning test), executive/attention[shape trails test, stroop color-word test(SCWT),reading the mind in the eyes test, the digit ordering test-A(DOT-A), and symbol digit modalities test], language(action naming test, Boston naming test, famous face test, similarity test, and verbal fluency test), and visuospatial functioning [complex figure test(CFT)].RESULTS: We found no significant differences between patients with and without a diagnosis of turbid phlegm blocking the upper orifices on neuropsychological test performance. Patients diagnosed with upper hyperactivity of liver Yang syndrome scored significantly lower on the SCWT-C executive test and the CFT-delayed recall memory test. Patients with excess syndrome scored significantly lower on the SCWT-C executive test, and significantly higher on the DOT-A executive test.CONCLUSION: Neuropsychological characteristics differ between PSCIND patients with different TCM classifications. 展开更多
关键词 Cognitive DYSFUNCTION Stroke SYNDROMES and signs NEUROPSYCHOLOGICAL tests
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