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Applications of advanced signal processing and machine learning in the neonatal hypoxic-ischemic electroencephalography 预览
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作者 Hamid Abbasi Charles P. Unsworth 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期222-231,共10页
Perinatal hypoxic-ischemic-encephalopathy significantly contributes to neonatal death and life-long disability such as cerebral palsy. Advances in signal processing and machine learning have provided the research comm... Perinatal hypoxic-ischemic-encephalopathy significantly contributes to neonatal death and life-long disability such as cerebral palsy. Advances in signal processing and machine learning have provided the research community with an opportunity to develop automated real-time identification techniques to detect the signs of hypoxic-ischemic-encephalopathy in larger electroencephalography/amplitude-integrated electroencephalography data sets more easily. This review details the recent achievements, performed by a number of prominent research groups across the world, in the automatic identification and classification of hypoxic-ischemic epileptiform neonatal seizures using advanced signal processing and machine learning techniques. This review also addresses the clinical challenges that current automated techniques face in order to be fully utilized by clinicians, and highlights the importance of upgrading the current clinical bedside sampling frequencies to higher sampling rates in order to provide better hypoxic-ischemic biomarker detection frameworks. Additionally, the article highlights that current clinical automated epileptiform detection strategies for human neonates have been only concerned with seizure detection after the therapeutic latent phase of injury. Whereas recent animal studies have demonstrated that the latent phase of opportunity is critically important for early diagnosis of hypoxic-ischemic-encephalopathy electroencephalography biomarkers and although difficult, detection strategies could utilize biomarkers in the latent phase to also predict the onset of future seizures. 展开更多
关键词 advanced signal processing AEEG automatic detection classification clinical EEG fetal HIE hypoxic-ischemic encephalopathy machine learning neonatal SEIZURE real-time identification review
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Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models 预览
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作者 Hamid Abbasi Charles P. Unsworth 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期828-837,共10页
Alongside clinical achievements,experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ ischemic e... Alongside clinical achievements,experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ ischemic encephalopathy (HIE).Due to the reasonably fair degree of flexibility with experiments,most of the research around HIE in the literature has been largely concerned with the neurodevelopmental outcome or how the frequency and duration of HI seizures could relate to the severity of perinatal brain injury,following HI insult.This survey concentrates on how EEG experimental studies using asphyxiated animal models (in rodents,piglets,sheep and non-human primate monkeys) provide a unique opportunity to examine from the exact time of HI event to help gain insights into HIE where human studies become difficult. 展开更多
关键词 animal models automatic detection clinical EEG FETAL HIE hypoxic-ischemic encephalopathy NEONATAL non-human PRIMATES review SEIZURE
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Taking central nervous system regenerative therapies to the clinic:curing rodents versus nonhuman primates versus humans 预览
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作者 Magdalini Tsintou Kyriakos Dalamagkas Nikos Makris 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期425-437,共13页
The central nervous system is known to have limited regenerative capacity.Not only does this halt the human body’s reparative processes after central nervous system lesions,but it also impedes the establishment of ef... The central nervous system is known to have limited regenerative capacity.Not only does this halt the human body’s reparative processes after central nervous system lesions,but it also impedes the establishment of effective and safe therapeutic options for such patients.Despite the high prevalence of stroke and spinal cord injury in the general population,these conditions remain incurable and place a heavy burden on patients’families and on society more broadly.Neuroregeneration and neural engineering are diverse biomedical fields that attempt reparative treatments,utilizing stem cells-based strategies,biologically active molecules,nanotechnology,exosomes and highly tunable biodegradable systems(e.g.,certain hydrogels).Although there are studies demonstrating promising preclinical results,safe clinical translation has not yet been accomplished.A key gap in clinical translation is the absence of an ideal animal or ex vivo model that can perfectly simulate the human microenvironment,and also correspond to all the complex pathophysiological and neuroanatomical factors that affect functional outcomes in humans after central nervous system injury.Such an ideal model does not currently exist,but it seems that the nonhuman primate model is uniquely qualified for this role,given its close resemblance to humans.This review considers some regenerative therapies for central nervous system repair that hold promise for future clinical translation.In addition,it attempts to uncover some of the main reasons why clinical translation might fail without the implementation of nonhuman primate models in the research pipeline. 展开更多
关键词 animal models central nervous system regeneration clinical translation exosomes HYDROGELS neural tissue engineering nonhuman PRIMATES spinal cord injury stem cells stroke
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Administration of pre/probiotics with conventional drug treatment in Alzheimer’s disease 预览
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作者 Jakub Hort Martin Valis Francesco Angelucci 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期448-449,共2页
Alzheimer’s disease(AD)is a neurodegenerative disease with long preclinical phase,typically followed by a slow decline in memory,thinking and reasoning abilities.The underlying pathological processes are not yet full... Alzheimer’s disease(AD)is a neurodegenerative disease with long preclinical phase,typically followed by a slow decline in memory,thinking and reasoning abilities.The underlying pathological processes are not yet fully elucidated,although two main disease hallmarks have been associated with AD pathology:amyloid beta species and neurofibrillary tangles.The plaques are deposits of a protein fragment called beta-amyloid(Aβ),which accumulates in the spaces between neurons.Tangles are twisted fibers of the tau protein,which accumulates inside the cells. 展开更多
关键词 ALZHEIMER AMYLOID clinical
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Constructing Large Scale Cohort for Clinical Study on Heart Failure with Electronic Health Record in Regional Healthcare Platform:Challenges and Strategies in Data Reuse 预览
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作者 Daowen Liu Liqi Lei +1 位作者 Tong Ruan Ping He 《中国医学科学杂志:英文版》 CAS CSCD 2019年第2期90-102,共13页
Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face ... Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform.In this paper,we propose methodology and process on constructing large scale cohorts which forms the basis of causality and comparative effectiveness relationship in epidemiology.We firstly constructed a Chinese terminology knowledge graph to deal with the diversity of vocabularies on regional platform.Secondly,we built special disease case repositories (i.e.,heart failure repository) that utilize the graph to search the related patients and to normalize the data.Based on the requirements of the clinical research which aimed to explore the effectiveness of taking statin on 180-days readmission in patients with heart failure,we built a large-scale retrospective cohort with 29647 cases of heart failure patients from the heart failure repository.After the propensity score matching,the study group (n=6346) and the control group (n=6346) with parallel clinical characteristics were acquired.Logistic regression analysis showed that taking statins had a negative correlation with 180-days readmission in heart failure patients.This paper presents the workflow and application example of big data mining based on regional EHR data. 展开更多
关键词 electronic health RECORDS CLINICAL terminology knowledge graph CLINICAL special disease case REPOSITORY evaluation of data quality large scale COHORT study
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Clinical and Therapeutic Management of Male Infertility in Thies, Senegal 预览
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作者 Yoro Diallo Modou Diop N’diaye +9 位作者 Saint Charles Kouka Mama Sy Diallo Mehdi Daher Amy Diamé Modou Faye Néné Mariama Sow Ramatoulaye Ly Cheikh Diop Seydou Diaw Cheickna Sylla 《泌尿学期刊(英文)》 2019年第1期1-10,共10页
Objective: To evaluate the clinical and therapeutic aspects of male subfertility in the Region of Thies. Patients and methods: This is a retrospective and analytical study involving patients followed for subfertility ... Objective: To evaluate the clinical and therapeutic aspects of male subfertility in the Region of Thies. Patients and methods: This is a retrospective and analytical study involving patients followed for subfertility over a period of 4 years from January 2013 to November 2017 at the level of 3 health structures in the region of Thies. Results: During the period, we collected 201 patients. The average age was 38 ± 8.4 years with a greater distribution in the age group 30-39 years. Primary subfertility was predominant with 81.1% of cases. The average duration was 5 years. We found a history of urethritis (4%) and orchiepididymitis (2.5%). Thirty-three percent of patients presented a varicocele (67 cases). Cryptorchidism was recorded in 2% of cases, testicular hypotrophy in 18.4% and testicular atrophy in 1.5%. The spermogram identified oligospermia-like abnormalities in 40.8% of cases, azoospermia 22.4%, and hypospermia 4%. For the qualitative abnormalities, we recorded cases of asthenospermia in 60.2% of the cases or 121 patients, a necrospermia 58.2% and a teratospermia 20.4%. A combination of these abnormalities was also reported as astheno-necrospermia in 19.4% of cases, oligo-astheno-necrospermia 14.4%, oligo-asthenotera-necrospermia 10% and oligo astero-teratospermia in 2.5%. An assessment of FSH, LH and testosterone was performed in 5.9% of the cases, or 12 patients. Varicocelectomy was performed in 68.4% of cases 19 patients, and (medically) assisted procreation in 2 patients. We recorded 13 cases of pregnancy. Conclusion: Male hypofertility is a real problem of management, and requires a particular approach. 展开更多
关键词 Hypofertility CLINICAL Spermogram VARICOCELE
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华山医院国家老年疾病临床医学研究中心建设初探
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作者 刘威 陈洁 +3 位作者 李卡 王海鹏 黄蔚 陈靖 《中华医院管理杂志》 CSCD 北大核心 2019年第2期137-140,共4页
随着我国人口老龄化以及老年人群健康保障需求的逐步加大,我国的医疗服务机构面临严峻的挑战。医学知识具有指导临床实践的潜力,但不能直接应用于临床实践,需要在多元化的各类组织之间建立协同研究网络。作者使用主题分析法对阻碍建立... 随着我国人口老龄化以及老年人群健康保障需求的逐步加大,我国的医疗服务机构面临严峻的挑战。医学知识具有指导临床实践的潜力,但不能直接应用于临床实践,需要在多元化的各类组织之间建立协同研究网络。作者使用主题分析法对阻碍建立医学协同机制的因素进行阐述,并归纳和整理了复旦大学附属华山医院国家老年疾病临床医学研究中心探索和建设过程中的经验。针对缺乏对于其他医疗机构提供的临床证据的信任,缺少跨组织的信息共享系统、转诊流程工作规范、医院管理层面的明确要求,缺少完善的补偿分配机制等实践中面临的主要问题,建议医院强化临床医学研究职能,在临床研究生态体系内发挥更加重要的作用。 展开更多
关键词 临床 医学研究 协同机制 价值链
Breast Cancer: Epidemiological, Clinical, and Therapeutic Aspects in Pointe Noire (Congo Brazzaville) 预览
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作者 C. F. S. Ngatali A. F. Bolenga Liboko +5 位作者 E. Ndounga Y. Mabila D. Moukassa J. B. Nkoua-Mbon P. E. G. Sounga Bandzouzi L. M. A. Boumba 《病理学期刊(英文)》 2019年第4期76-85,共10页
Introduction: Breast cancer is the leading cancer and the leading cause of cancer death in women worldwide. The objective of our study was to describe the epidemiological, clinical and therapeutic aspects of breast ca... Introduction: Breast cancer is the leading cancer and the leading cause of cancer death in women worldwide. The objective of our study was to describe the epidemiological, clinical and therapeutic aspects of breast cancer at the General Hospital of Loandjili in Pointe Noire. Patients and Methods: This was a descriptive and cross-sectional study that took place in the Cancer Department of the General Hospital of Loandjili in Pointe Noire during the period from January 1st, 2012 to December 31st, 2016 for duration of 5 years. 54 records of patients over 18 years of age with histological evidence were collected. The variables studied were: age, level of education, time to presentation, telltale sign, stage of extension, histological type, and histological grade. Chi-square test was used to compare variables and groups. Results: At the end of this study, we collected 54 files of breast cancer patients from 150 patients hospitalized in the Cancer Department. The frequency of breast cancer was 36%. The average age was 50 ± 13.6 years;the extremes were 27 years and 79 years. The most represented age group was from 37 to 40 years old with a percentage of 28%. The patient’s level of study was primary in the majority of cases (57%). The most represented histological type was invasive ductal carcinoma, (100%). The majority of patients arrived at advanced stages 44.4% and metastatic stages 26%. Patients were treated in most of cases by chemotherapy (82%), surgery (42%) and radiotherapy (10%). There was a correlation between time of presentation and stage of extension. Conclusion: Breast cancer is the first cancer of the woman in Pointe Noire. Patients arrive at advanced stages;the most common histological type is invasive ductal carcinoma. The presentation time is correlated with the extension stage. These results suggest the establishment of a cancer control program in developing countries. 展开更多
关键词 EPIDEMIOLOGICAL CLINICAL Therapeutic Breast Cancer Pointe Noire
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Clinical Big Data and Deep Learning:Applications,Challenges,and Future Outlooks
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作者 Ying Yu Min Li +2 位作者 Liangliang Liu Yaohang Li Jianxin Wang 《大数据挖掘与分析(英文)》 2019年第4期288-305,共18页
The explosion of digital healthcare data has led to a surge of data-driven medical research based on machine learning. In recent years, as a powerful technique for big data, deep learning has gained a central position... The explosion of digital healthcare data has led to a surge of data-driven medical research based on machine learning. In recent years, as a powerful technique for big data, deep learning has gained a central position in machine learning circles for its great advantages in feature representation and pattern recognition. This article presents a comprehensive overview of studies that employ deep learning methods to deal with clinical data. Firstly,based on the analysis of the characteristics of clinical data, various types of clinical data(e.g., medical images,clinical notes, lab results, vital signs, and demographic informatics) are discussed and details provided of some public clinical datasets. Secondly, a brief review of common deep learning models and their characteristics is conducted. Then, considering the wide range of clinical research and the diversity of data types, several deep learning applications for clinical data are illustrated: auxiliary diagnosis, prognosis, early warning, and other tasks.Although there are challenges involved in applying deep learning techniques to clinical data, it is still worthwhile to look forward to a promising future for deep learning applications in clinical big data in the direction of precision medicine. 展开更多
关键词 DEEP learning CLINICAL data Electronic Health Record(EHR) medical image CLINICAL NOTE
Clinic Pathological Study of an Eccrine Spiradenoma 预览
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作者 Xiao Lin Xiong Zhang 《生物科学与医学(英文)》 2019年第5期6-10,共5页
Eccrine Spiradenoma (ES) is an exceedingly rare sweat-gland tumor, it usually presents as a solitary lesion and painful nodule. ES is a kind of neoplasm with distinct histological characteristics and nonspecific clini... Eccrine Spiradenoma (ES) is an exceedingly rare sweat-gland tumor, it usually presents as a solitary lesion and painful nodule. ES is a kind of neoplasm with distinct histological characteristics and nonspecific clinical manifestations. Most ES cases have a benign course;however, malignant transformation would occur after a long period of latency. The diagnosis mostly depends on the clinic symptom, histological features and immunohistochemistry. Here, we report a case of ES and literature review. The aim of this study is to understand clinic and histological features for ES. 展开更多
关键词 ECCRINE spiradenoma CLINICAL PATHOLOGY IMMUNOHISTOCHEMISTRY DIAGNOSIS
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Combination of fire needle and filiform needle for frozen shoulder in different clinical stages
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作者 高艳 刘美颖 +3 位作者 王爽 陈跃辉 解秸萍 冀美琦 《世界针灸杂志:英文版》 CSCD 2019年第2期119-122,共4页
Objective:To observe the clinical efficacy of fire needle combined with filiform needle for different clinical stage frozen shoulders,and to choose the best treatment opportunity for clinical treatment of frozen shoul... Objective:To observe the clinical efficacy of fire needle combined with filiform needle for different clinical stage frozen shoulders,and to choose the best treatment opportunity for clinical treatment of frozen shoulder.Methods:120 patients with frozen shoulders who met the inclusion criteria were numbered according to the visiting order.They were randomized into control group(60 cases)and treatment group(60 cases)according to the random number table.Both groups were treated with filiform needles once every other day and 3 times a week,and a course of treatment included 6 times and 2 courses were taken.The treatment group was treated by applying a fire needling point bloodletting on the local tender points once a week.Jiānyú(肩髃 LI 15),Jiānliáo(肩髎 TE 14),Jiānzhēn(肩贞 SI 9),Tiáokǒu(条口 ST 38),and local tender points were taken according to different meridian pains.The clinical efficacy of the frozen shoulder patients in the two groups in different clinical stages was compared.The evaluation indicators were scores of pain,joint activity range and activities of daily living,as well as clinical efficacy of traditional Chinese medicine.Results:After treatment,the total scores of hundred-mark five-grade in both groups were significantly higher than those before treatment,and the differences were statistically significant(Treatment group82.02 ± 14.23 vs 43.37 ± 22.10,Control group 66.80 ± 18.98 vs 42.67 ± 23.03,both P<0.01),and the total score of the treatment group was significantly higher than the control group(P<0.01).The hundred-mark five-grade assessment scores after treatment in the treatment group during the frozen stage were significantly higher than the control group(77.2± 14.40 vs 68.43 ± 16.94,P<0.01);as to the clinical efficacy,the total effective rate of the treatment group was higher than the control group,and the difference was statistically significant(91.67% vs 76.67%,P<0.01);The total effective rate of the control group in the acute stage and functional recovery stage was co 展开更多
关键词 PERIARTHRITIS of the SHOULDER Clinical STAGE Fire NEEDLE FILIFORM NEEDLE
鼻部美容整形综合手术的临床疗效分析
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作者 白云 许国明 +1 位作者 范明明 贾维顺 《智慧健康》 2019年第24期165-166,共2页
目的研究鼻部美容整形综合手术的临床治疗效果,以此提高患者满意度,改善患者不良情绪。方法选取2015年4月至2018年6月我院收治的100例行鼻部美容整形综合手术的患者为研究对象,总结手术疗效,以此分析患者满意度和心理状态、生活质量等... 目的研究鼻部美容整形综合手术的临床治疗效果,以此提高患者满意度,改善患者不良情绪。方法选取2015年4月至2018年6月我院收治的100例行鼻部美容整形综合手术的患者为研究对象,总结手术疗效,以此分析患者满意度和心理状态、生活质量等情况。结果 100例患者实施鼻部美容整形综合手术完成后,术后切口感染0例,均取得较好的恢复效果,术后6个月进行随访,鼻尖软组织增生引起鼻外形发生改变1例,患者不满意鼻外形效果而实施二次手术进行修复,达到理想效果,100例患者非常满意52例,满意47例,不满意1例,手术满意度达99%;术后,焦虑、抑郁等心理评分优于手术前,手术前后心理变化情况对比有显著差异(P<0.05);术后,患者各项生活质量评分(心理健康、物质生活、躯体健康、社会功能)均优于手术前,手术前后生活质量对比有显著差异(P<0.05)。结论实施鼻部美容整形综合手术对鼻外观改善效果好,保证手术顺利完成,提高美学效果,以此改善患者不良心理和生活质量。 展开更多
关键词 鼻部 美容整形 综合手术 临床 疗效
The clinical application of Yanghe Decoction 预览
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作者 Jin-Feng Liu Xiong-Zhi Wu 《TMR药物联合治疗》 2019年第2期75-84,共10页
Yanghe Decoction is a representative prescription of such prescriptions as warming up the yang and dissipating the cold.It has the functions of warming the blood and dispelling cold and stagnation.Yanghe Decoction has... Yanghe Decoction is a representative prescription of such prescriptions as warming up the yang and dissipating the cold.It has the functions of warming the blood and dispelling cold and stagnation.Yanghe Decoction has effects on many diseases.The principle of this kind of disease is blood deficiency and yang,and the clinical manifestation is cold stagnation.Such diseases often occur in multiple systems and in multiple aspects.This article summarizes the compatibility of Yanghe Decoction and its clinical application by reviewing the related literature analysis in recent years,and provides a broad idea for the application of Yanghe Decoction. 展开更多
关键词 Yanghe DECOCTION PRESCRIPTION compatibility CLINICAL APPLICATION
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巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害的疗效分析 预览
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作者 徐森华 毕庆国 +1 位作者 徐成兴 许迎烈 《中南医学科学杂志》 CAS 2019年第3期270-273,共4页
巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害具有一定的优势,对60例脾肾亏虚型遗忘型轻度认知损害患者分为巴戟天颗粒治疗组(观察组)和尼莫地平片治疗组(对照组),比较两组治疗前后中西医疗效及同型半胱氨酸(Hcy)、纤维蛋白原(FIB)水平... 巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害具有一定的优势,对60例脾肾亏虚型遗忘型轻度认知损害患者分为巴戟天颗粒治疗组(观察组)和尼莫地平片治疗组(对照组),比较两组治疗前后中西医疗效及同型半胱氨酸(Hcy)、纤维蛋白原(FIB)水平。其中,观察组总有效率高于对照组,两组患者治疗3个月后Hcy、FIB水平较治疗前均明显降低,且治疗3个月后两组比较,观察组Hcy、FIB水平降低较对照组更明显(P<0.05)。巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害有确切疗效,值得临床推广应用。 展开更多
关键词 巴戟天颗粒 脾肾亏虚型 遗忘型 轻度认知损害 临床
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Relationship between serum homocysteine levels and long-term outcomes in patients with ST-segment elevation myocardial infarction
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作者 Jin Si Xue-Wen Li +6 位作者 Yang Wang Ying-Hua Zhang Qing-Qing Wu Lei-Min Zhang Xue-Bing Zuo Jing Gao Jing Li 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第9期1028-1036,共9页
Background:The mortality of cardiovascular disease is constantly rising,and novel biomarkers help us predict residual risk.This study aimed to evaluate the predictive value of serum homocysteine (HCY) levels on progno... Background:The mortality of cardiovascular disease is constantly rising,and novel biomarkers help us predict residual risk.This study aimed to evaluate the predictive value of serum homocysteine (HCY) levels on prognosis in patients with ST-segment elevation myocardial infarction (STEMI).Methods:The 419 consecutive patients with STEMI,treated at one medical center,from March 2010 to December 2015 were retrospectively investigated.Peripheral blood samples were obtained within 24 h of admission and HCY concentrations were measured using an enzymatic cycling assay.The patients were divided into high HCY level (H-HCY) and low HCY level (L-HCY) groups.Short- and long-term outcomes were compared,as were age-based subgroups (patients aged 60 years and younger vs.those older than 60 years).Statistical analyses were mainly conducted by Student t-test,Chi-squared test,logistic regression,and Cox proportional-hazards regression.Results:The H-HCY group had more males (84.6% vs.75.4%,P=0.018),and a lower prevalence of diabetes (20.2% vs.35.5%,P<0.001),compared with the L-HCY group.During hospitalization,there were seven mortalities in the L-HCY group and 10 in the H-HCY group (3.3% vs.4.8%,P= 0.440).During the median follow-up period of 35.8 (26.9–46.1) months,33 (16.2%) patients in the L-HCY group and 48 (24.2%) in the H-HCY group experienced major adverse cardiovascular and cerebrovascular events (MACCE)(P=0.120).History of hypertension (hazard ratio [HR]:1.881,95% confidence interval [CI]:1.178–3.005,P=0.008) and higher Killip class (HR:1.923,95% CI:1.419–2.607,P<0.001),but not HCY levels (HR:1.007,95% CI:0.987–1.027,P=0.507),were significantly associated with long-term outcomes.However,the subgroup analysis indicated that in older patients,HCY levels were significantly associated with long-term outcomes (HR:1.036,95% CI:1.011–1.062,P=0.005).Conclusion:Serum HCY levels did not independently predict in-hospital or long-term outcomes in patients with STEMI;however,among elderly patients with STEMI,this study reveal 展开更多
关键词 HOMOCYSTEINE Acute ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PERCUTANEOUS coronary intervention Clinical outcome
Clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer
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作者 Zi-Jun Zhao Xiao-Yuan Gu +1 位作者 Wei-Qiang Zhang Li Zhou 《海南医科大学学报(英文版)》 2019年第2期53-56,共4页
Objective:To investigate the clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer.Methods: Ninety-eight patients with non-small cell lung cancer admitted to our hospit... Objective:To investigate the clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer.Methods: Ninety-eight patients with non-small cell lung cancer admitted to our hospital from December 2015 to December 2017 were randomly divided into the control group (49 cases) and the experimental group (49 cases). The group was treated with conventional first-line chemotherapy (pemetrexed plus carboplatin). The experimental group was treated with bevacizumab plus afatinib. The therapeutic effects of the two groups were observed. Immune function, angiogenesis related indicators and incidence of adverse reactions.Results: The levels of CD3+, CD4+, CD4+/CD8+, IgG, IgM, IgA, VEGF, BFGF and HDGF were not significantly different between the two groups. After treatment, both groups were reduced, and the experimental group CD3+, CD4+, The levels of CD4+/CD8+, IgG, IgM and IgA were significantly higher than those of the control group. The levels of VEGF, BFGF and HDGF were significantly lower than those of the control group. The effective rate of the experimental group was significantly higher than that of the control group. There was no significant difference in the rate.Conclusion: Bevacizumab combined with afatinib can effectively improve the therapeutic effect of patients with non-small cell lung cancer. It has been the expression of angiogenic factors, improve the immune function of patients and increase the adverse reactions of patients, which is worthy of clinical promotion. 展开更多
关键词 BEVACIZUMAB AFATINIB NON-SMALL cell LUNG cancer CLINICAL EFFICACY
Respiratory virus infections and inflammatory cytokines in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease
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作者 赵春柳 《中国医学文摘:内科学分册(英文版)》 2019年第1期38-39,共2页
Objective To investigate the characteristics of respiratory viral infections, and correlation between inflammatory cytokines and respiratory virus infections in patients with acute exacerbations of chronic obstructive... Objective To investigate the characteristics of respiratory viral infections, and correlation between inflammatory cytokines and respiratory virus infections in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD). Methods A prospective cohort of patients with acute exacerbations of COPD was enrolled. The sputum of all patients were collected, and 15 respiratory viruses were detected using multi-channel real-time fluorescence quantitative PCR. The clinical characteristics associated with viral infections were analyzed. 展开更多
关键词 COPD SPUTUM CLINICAL
Compound Daxueteng Enemas Combined with GnRH-a on Endometriosis after Laparoscopic Surgery: a clinical research
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作者 杨华娣 《中国医学文摘:内科学分册(英文版)》 2019年第2期70-71,共2页
Objective To evaluate the effect of Compound Daxueteng Enemas combined with gonadotropin-releasing hormone agonists (GnRH-a) on endometriosis (EMs) after laparoscopic surgery. Methods From January 2015 to March 2017,6... Objective To evaluate the effect of Compound Daxueteng Enemas combined with gonadotropin-releasing hormone agonists (GnRH-a) on endometriosis (EMs) after laparoscopic surgery. Methods From January 2015 to March 2017,65 EMs cases of blood and heat accumulationsyndrome undergoing laparoscopic conservative surgeryin Zhejiang Provincial Hospital of TCM were randomlyassigned to group of Compound Daxueteng Enemaswith 18 cases (given retention enema of Compound DaxuetengEnemas after surgery),group of GnRH-a with 24cases (given hypodermic injection of GnRH- a after surgery)and group of combined treatment with 23 cases(given retention enema of Compound Daxueteng Enemascombined with hypodermic injection of GnRH-a after surgery).The treatment course lasted 4 months. 展开更多
关键词 Daxueteng Enemas GNRH-A on ENDOMETRIOSIS AFTER LAPAROSCOPIC Surgery a clinical research
结直肠癌患者瘤组织中EGFR、COX-2表达及其临床意义 预览
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作者 谭志军 蒋宏 《世界最新医学信息文摘(电子版)》 2019年第17期11-12,共2页
目的考察结直肠癌患者瘤组织中EGFR、COX-2表达及其临床意义。方法以2013至2016年在我院接受手术治疗的结直肠癌患者为研究对象,收集患者临床资料,采用免疫组化法分析肿瘤样本中EGFR、COX-2表达水平,卡方检验比较EGFR、COX-2表达与患者... 目的考察结直肠癌患者瘤组织中EGFR、COX-2表达及其临床意义。方法以2013至2016年在我院接受手术治疗的结直肠癌患者为研究对象,收集患者临床资料,采用免疫组化法分析肿瘤样本中EGFR、COX-2表达水平,卡方检验比较EGFR、COX-2表达与患者临床病理特征的关系。结果 EGFR表达与患者瘤径(P<0.05)、N分期显著相关(P<0.05),COX-2表达与患者Dukes分期(P<0.01)、N分期(P<0.05)、肿瘤分级显著相关(P<0.01);EGFR表达与COX-2表达显著相关(P<0.05)。结论肿瘤组织中EGFR和COX-2的表达与结直肠癌瘤组织的病理学特征显著相关,可能与结直肠癌分化和转移有关。 展开更多
关键词 结直肠 肿瘤 临床
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伴贫血的IgA肾病患者临床病理及预后分析
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作者 吴勐 张小红 +1 位作者 林矜 万建新 《中华肾脏病杂志》 CAS CSCD 北大核心 2019年第10期752-757,共6页
目的分析伴贫血的IgA肾病(IgAN)患者临床病理特征及预后的影响因素。方法回顾性分析于2006年1月1日至2016年12月31日在福建医科大学附属第一医院确诊为原发性IgAN患者的临床和病理资料。按照患者是否贫血分为贫血组和非贫血组,收集比较... 目的分析伴贫血的IgA肾病(IgAN)患者临床病理特征及预后的影响因素。方法回顾性分析于2006年1月1日至2016年12月31日在福建医科大学附属第一医院确诊为原发性IgAN患者的临床和病理资料。按照患者是否贫血分为贫血组和非贫血组,收集比较两组患者的临床和病理资料。以肾活检日期为起点,随访至2018年1月1日,采用Kaplan-Meier法绘制生存曲线,两组生存曲线的比较采用Log-rank检验;采用多因素Cox比例风险模型分析IgAN患者预后的影响因素。结果共纳入231例研究对象,男性122例(52.8%),男∶女=1.12∶1;年龄(34.8±10.1)岁(15~68岁);其中贫血组70例(30.3%),非贫血组161例(69.7%)。与非贫血组比较,贫血组女性患者比例更高,血白蛋白更低,内皮细胞增殖(E1)、肾小管萎缩/肾间质纤维化(T1/2)、新月体形成比例(C1/2)更高,差异均有统计学意义(均P<0.05)。中位随访时间为6.3年(0.3~12.9年)。两组患者生存曲线比较,贫血组患者肾脏累积生存率低于非贫血组(χ^2=15.234,P<0.001)。多因素Cox比例风险模型分析显示,合并高血压(HR=2.988,95%CI1.276~6.999,P=0.012)、24h尿蛋白量升高(HR=1.103,95%CI1.046~1.163,P<0.001)、贫血(HR=3.820,95%CI1.674~8.719,P=0.001)、估算肾小球滤过率(eGFR)<60ml·min^-1·(1.73m2^)^-1(HR=3.725,95%CI1.639~8.462,P=0.002)、肾小管萎缩/间质纤维化(T1/2)(HR=3.770,95%CI1.026~13.852,P=0.046)、肾小球节段硬化/粘连(S1)(HR=4.211,95%CI1.139~15.576,P=0.031)是IgAN患者发生不良肾脏预后的独立危险因素。结论伴贫血的IgAN患者临床病理表现相对较严重,肾脏累积生存率较低。贫血、肾小管萎缩/间质纤维化(T1/2)、肾小球节段硬化/粘连(S1)、高血压、24h尿蛋白量升高、eGFR<60ml?min-1?(1.73m2)-1是IgAN患者发生不良肾脏预后的独立危险因素。 展开更多
关键词 肾小球肾炎 IgA 贫血 病理学 临床 预后
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