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Therapeutic effect of regulating autophagy in spinal cord injury: a network meta-analysis of direct and indirect comparisons 预览
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作者 Duo Zhang Di Zhu +4 位作者 Fang Wang Ji-Chao Zhu Xu Zhai Yuan Yuan Chen-Xi Li 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1120-1132,共13页
Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,th... Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,the effect of regulating autophagy and whether autophagy is detrimental or beneficial after spinal cord injury remain unclear.Therefore,in this study we evaluated the effects of autophagy regulation on spinal cord injury in rats by direct and indirect comparison,in an effort to provide a basis for further research.Data source:Relevant literature published from inception to February 1,2018 were included by searching Wanfang,CNKI,Web of Science,MEDLINE(OvidSP),PubMed and Google Scholar in English and Chinese.The keywords included"autophagy","spinal cord injury",and"rat".Data selection:The literature included in vivo experimental studies on autophagy regulation in the treatment of spinal cord injury(including intervention pre-and post-spinal cord injury).Meta-analyses were conducted at different time points to compare the therapeutic effects of promoting or inhibiting autophagy,and subgroup analyses were also conducted.Outcome measure:Basso,Beattie,and Bresnahan scores.Results:Of the 622 studies,33 studies of median quality were included in the analyses.Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=1.80,95%CI:0.81-2.79,P=0.0004),3 days(MD=0.92,95%CI:0.72-1.13,P<0.00001),1 week(MD=2.39,95%CI:1.85-2.92,P<0.00001),2 weeks(MD=3.26,95%CI:2.40-4.13,P<0.00001),3 weeks(MD=3.13,95%CI:2.51-3.75,P<0.00001)and 4 weeks(MD=3.18,95%CI:2.43-3.92,P<0.00001)after spinal cord injury with upregulation of autophagy compared with the control group(drug solvent control,such as saline group).Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=6.48,95%CI:5.83-7.13,P<0.00001),2 weeks(MD=2.43,95%CI:0.79-4.07,P=0.004),3 weeks(MD=2.96,95%CI:0.09-5.84,P=0.04)and 4 weeks(MD=4.41,95%CI:1.08-7.75,P=0.01)after spinal cord injury with downregulation of autophagy compared with the control group.Indirect comparison of upr 展开更多
关键词 AUTOPHAGY Basso Beattie and Bresnahan scores indirect comparison META-ANALYSIS nerve regeneration neural regeneration neurological function rat models REGULATION spinal cord injury strategy analysis
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Effects of neural stem cell transplantation on the motor function of rats with contusion spinal cord injuries:a meta-analysis 预览
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作者 Kai Qian Tuo-Ye Xu +7 位作者 Xi Wang Tao Ma Kai-Xin Zhang Kun Yang Teng-Da Qian Jing Shi Li-Xin Li Zheng Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期748-758,共11页
Objective:To judge the efficacies of neural stem cell(NSC)transplantation on functional recovery following contusion spinal cord injuries(SCIs).Data sources:Studies in which NSCs were transplanted into a clinically re... Objective:To judge the efficacies of neural stem cell(NSC)transplantation on functional recovery following contusion spinal cord injuries(SCIs).Data sources:Studies in which NSCs were transplanted into a clinically relevant,standardized rat model of contusion SCI were identified by searching the PubMed,Embase and Cochrane databases,and the extracted data were analyzed by Stata 14.0.Data selection:Inclusion criteria were that NSCs were used in in vivo animal studies to treat contusion SCIs and that behavioral assessment of locomotor functional recovery was performed using the Basso,Beattie,and Bresnahan lo-comotor rating scale.Exclusion criteria included a follow-up of less than 4 weeks and the lack of control groups.Outcome measures:The restoration of motor function was assessed by the Basso,Beattie,and Bresnahan locomotor rating scale.Results:We identified 1756 non-duplicated papers by searching the aforementioned electronic databases,and 30 full-text articles met the inclusion criteria.A total of 37 studies reported in the 30 articles were included in the meta-analysis.The meta-analysis results showed that transplanted NSCs could improve the motor function recovery of rats following contusion SCIs,to a moderate extent(pooled standardized mean difference(SMD)=0.73;95%confidence interval(CI):0.47–1.00;P<0.001).NSCs obtained from different donor species(rat:SMD=0.74;95%CI:0.36–1.13;human:SMD=0.78;95%CI:0.31–1.25),at different donor ages(fetal:SMD=0.67;95%CI:0.43–0.92;adult:SMD=0.86;95%CI:0.50–1.22)and from different origins(brain-derived:SMD=0.59;95%CI:0.27–0.91;spinal cord-derived:SMD=0.51;95%CI:0.22–0.79)had similar efficacies on improved functional recovery;however,adult induced pluripotent stem cell-derived NSCs showed no significant efficacies.Furthermore,the use of higher doses of transplanted NSCs or the administration of immunosuppressive agents did not promote better locomotor function recovery(SMD=0.45;95%CI:0.21–0.70).However,shorter periods between the contusion induction and the NSC tr 展开更多
关键词 Basso Beattie and Bresnahan locomotor rating scale CELL TRANSPLANTATION META-ANALYSIS motor functional recovery NEURAL regeneration NEURAL stem CELL NEURAL stem CELL TRANSPLANTATION rat model SPINAL CONTUSION SPINAL cord injury
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Serum and cerebrospinal fluid tau protein level as biomarkers for evaluating acute spinal cord injury severity and motor function outcome 预览
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作者 Ying Tang Hong-Liang Liu +6 位作者 Ling-Xia Min Hao-Shi Yuan Lei Guo Peng-Bo Han Yu-Xin Lu Jian-Feng Zhong Dong-Lin Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第5期896-902,共7页
Tau protein,a microtubule-associated protein,has a high specific expression in neurons and axons.Because traumatic spinal cord injury mainly affects neurons and axons,we speculated that tau protein may be a promising ... Tau protein,a microtubule-associated protein,has a high specific expression in neurons and axons.Because traumatic spinal cord injury mainly affects neurons and axons,we speculated that tau protein may be a promising biomarker to reflect the degree of spinal cord injury and prognosis of motor function.In this study,160 female Sprague-Dawley rats were randomly divided into a sham group,and mild,moderate,and severe spinal cord injury groups.A laminectomy was performed at the T8 level to expose the spinal cord in all groups.A contusion lesion was made with the NYU-MASCIS impactor by dropping a 10 g rod from heights of 12.5 mm(mild),25 mm(moderate)and 50 mm(severe)upon the exposed dorsal surface of the spinal cord.Tau protein levels were measured in serum and cerebrospinal fluid samples at 1,6,12,24 hours,3,7,14 and 28 days after operation.Locomotor function of all rats was assessed using the Basso,Beattie and Bresnahan locomotor rating scale.Tau protein concentration in the three spinal cord injury groups(both in serum and cerebrospinal fluid)rapidly increased and peaked at 12 hours after spinal cord injury.Statistically significant positive linear correlations were found between tau protein level and spinal cord injury severity in the three spinal cord injury groups,and between the tau protein level and Basso,Beattie,and Bresnahan locomotor rating scale scores.The tau protein level at 12 hours in the three spinal cord injury groups was negatively correlated with Basso,Beattie,and Bresnahan locomotor rating scale scores at 28 days(serum:r=?0.94;cerebrospinal fluid:r=?0.95).Our data suggest that tau protein levels in serum and cerebrospinal fluid might be a promising biomarker for predicting the severity and functional outcome of traumatic spinal cord injury. 展开更多
关键词 nerve REGENERATION spinal cord INJURY tau INJURY SEVERITY OUTCOME cerebrospinal fluid SERUM biomarker Basso Beattie and Bresnahan LOCOMOTOR rating scale neural REGENERATION
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Local injection of bone morphogenetic protein 7 promotes neuronal regeneration and motor function recovery after acute spinal cord injury 预览
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作者 Chen Chen Guang-Chao Bai +2 位作者 Hong-Liang Jin Kun Lei Kuan-Xin Li 《中国神经再生研究:英文版》 SCIE CAS CSCD 2018年第6期1054-1060,共7页
关键词 形态基因 蛋白质 绳索 功能恢复 马达 注射 骨头 损害
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心灵的沼泽——解读安·比蒂的小说《刻画维尔》 预览 被引量:1
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作者 李晨歌 《陇东学院学报》 2011年第5期 39-41,共3页
将美国当代主流小说名家安·比蒂的小说《刻画雏尔》置于后现代消费社会的文化语境下进行解读。通过分析文本中的具体实例,说明在后现代工业高度繁荣、物质充盈的消费社会中,当代人的精神世界表现出三个共同特征:冰冷无情、隔绝... 将美国当代主流小说名家安·比蒂的小说《刻画雏尔》置于后现代消费社会的文化语境下进行解读。通过分析文本中的具体实例,说明在后现代工业高度繁荣、物质充盈的消费社会中,当代人的精神世界表现出三个共同特征:冰冷无情、隔绝疏离、浅薄轻率。而这一主题不仅具有深刻的现实意义,也体现了以安·比蒂为代表的美国简约派新现实主义小说的本质特征。 展开更多
关键词 安·比蒂 《刻画维尔》 主题 精神世界
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神经行为学检测和改良BBB运动功能评定在脑瘫大鼠运动功能评定中的应用 预览 被引量:8
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作者 李晓捷 郭岚敏 《中国康复医学杂志》 CAS CSCD 北大核心 2008年第12期 1067-1070,共4页
目的:探讨脑瘫大鼠运动功能评价的最佳方法。方法:采用孕鼠腹腔注射LPS制备脑瘫动物模型。随机选取对照组(A组)足月仔鼠60只,LPS组足月仔鼠120只分为早期干预组(B1组)和非干预组(B2组)各60只。各组于生后25d进行神经行为学检测... 目的:探讨脑瘫大鼠运动功能评价的最佳方法。方法:采用孕鼠腹腔注射LPS制备脑瘫动物模型。随机选取对照组(A组)足月仔鼠60只,LPS组足月仔鼠120只分为早期干预组(B1组)和非干预组(B2组)各60只。各组于生后25d进行神经行为学检测,B1组中检测出的CP鼠(B1CP组)继续早期干预,B2组中检测出的CP鼠(B2CP组)常规饲养,A组中随机选取10只鼠作为对照组(A’组);A’组、B1CP组和B2CP组仔鼠分别于25d及42d进行神经行为学检测和运动功能评定。结果:①25dB1组鉴定出7只CP鼠,B2组13只CP鼠,A组中无CP鼠。②B1CP组第25天与第42天各项检测结果比较:悬吊试验、斜坡试验、旷场实验、拒俘反应及改良的BBB运动功能评分均有显著性差异(P〈0.01):B2CP组和A’组大鼠25d与42d各项检测结果比较无显著性差异(P〉0.05)。结论:①神经行为学检测可有效鉴定CP大鼠的运动功能。②改良BBB运动功能评定适用于CP大鼠的运动功能评定。③联合应用神经行为学检测与改良13BB运动功能评定可全面反映CP大鼠运动功能状况。 展开更多
关键词 早期干预 宫内感染 脑性瘫痪 运动功能评定 Basso—Beattie—Bresnahan运动功能评定
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神经干细胞与许旺细胞共移植于大鼠损伤脊髓 被引量:2
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作者 夏雷 万虹 +3 位作者 历俊华 郝淑煜 杨飞 王身国 《中华神经外科杂志》 CSCD 北大核心 2008年第10期740-743,共4页
目的观察神经干细胞与许旺细胞共移植于大鼠半横断脊髓损伤处神经干细胞的迁移、存活、分化及对损伤脊髓的修复作用。方法绿色荧光蛋白(GFP)标记脊髓神经干细胞后与许旺细胞共移植于大鼠半横断脊髓损伤处,免疫荧光染色和电镜技术分... 目的观察神经干细胞与许旺细胞共移植于大鼠半横断脊髓损伤处神经干细胞的迁移、存活、分化及对损伤脊髓的修复作用。方法绿色荧光蛋白(GFP)标记脊髓神经干细胞后与许旺细胞共移植于大鼠半横断脊髓损伤处,免疫荧光染色和电镜技术分别观察神经干细胞的迁移、存活、分化及新生的髓鞘。皮层运动诱发电位(CMEPs)及BBB评分分别检测大鼠运动功能的恢复。结果在神经干细胞与许旺细胞共移植组,损伤脊髓的头端、尾端及对侧可见明显的GFP阳性细胞及GaLC/GFP、GFAP/GFP、NSE/GFP、SYN/GFP双阳性细胞,电镜下新生的髓鞘最多,CMEPs恢复百分率和振幅明显高于其他两组,但BBB评分与神经干细胞单移植组差异无统计学意义。结论神经干细胞和许旺细胞体内共移植可促进神经干细胞的迁移、存活、分化及脊髓运动功能的恢复。 展开更多
关键词 神经干细胞 许旺细胞 绿色荧光蛋白 运动诱发电位 BBB评分
Changes in neurological and pathological outcomes in a modified rat spinal cord injury model with closed canal 预览
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作者 Xin Sun Xing-Zhen Liu +4 位作者 Jia Wang Hai-Rong Tao Tong Zhu Wen-Jie Jin Kang-Ping Shen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期697-704,共8页
Most animal spinal cord injury models involve a laminectomy,such as the weight drop model or the transection model.However,in clinical practice,many patients undergo spinal cord injury while maintaining a relatively c... Most animal spinal cord injury models involve a laminectomy,such as the weight drop model or the transection model.However,in clinical practice,many patients undergo spinal cord injury while maintaining a relatively complete spinal canal.Thus,open spinal cord injury models often do not simulate real injuries,and few previous studies have investigated whether having a closed spinal canal after a primary spinal cord injury may influence secondary processes.Therefore,we aimed to assess the differences in neurological dysfunction and pathological changes between rat spinal cord injury models with closed and open spinal canals.Sprague-Dawley rats were randomly divided into three groups.In the sham group,the tunnel was expanded only,without inserting a screw into the spinal canal.In the spinal cord injury with open canal group,a screw was inserted into the spinal canal to cause spinal cord injury for 5 minutes,and then the screw was pulled out,leaving a hole in the vertebral plate.In the spinal cord injury with closed canal group,after inserting a screw into the spinal canal for 5 minutes,the screw was pulled out by approximately 1.5 mm and the flat end of the screw remained in the hole in the vertebral plate so that the spinal canal remained closed;this group was the modified model,which used a screw both to compress the spinal cord and to seal the spinal canal.At 7 days post-operation,the Basso-Beattie-Bresnahan scale was used to measure changes in neurological outcomes.Hematoxylin-eosin staining was used to assess histopathology.To evaluate the degree of local secondary hypoxia,immunohistochemical staining and western blot assays were applied to detect the expression of hypoxia-inducible factor 1α(HIF-1α)and vascular endothelial growth factor(VEGF).Compared with the spinal cord injury with open canal group,in the closed canal group the Basso-Beattie-Bresnahan scores were lower,cell morphology was more irregular,the percentage of morphologically normal neurons was lower,the percentages of HIF-1α-and VEGF-immunorea 展开更多
关键词 Basso-Beattie-Bresnahan scores CLOSED SPINAL CANAL HIF-1α hypoxia MODEL nerve regeneration open SPINAL CANAL rat secondary INJURY SPINAL cord INJURY VEGF
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运动诱发电位和BBB评分在大鼠脊髓损伤功能评价中的相关性研究
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作者 马善峰 马奎 吕合作 《中华解剖与临床杂志》 2019年第3期299-304,共6页
目的 探讨大鼠脊髓损伤功能评价指标运动诱发电位( MEP)和 Basso-Beattie-Bresnahan (BBB)评分的相关性.方法 成年雌性SD大鼠16只,采用数字表法随机分为对照组和实验组,每组8只.对照组只施行手术,不给予外力打击.实验组应用PSI-IH装置... 目的 探讨大鼠脊髓损伤功能评价指标运动诱发电位( MEP)和 Basso-Beattie-Bresnahan (BBB)评分的相关性.方法 成年雌性SD大鼠16只,采用数字表法随机分为对照组和实验组,每组8只.对照组只施行手术,不给予外力打击.实验组应用PSI-IH装置复制脊髓损伤模型.记录并分析损伤前以及损伤后3 h、1 d、3 d、1周、2周、3周、4周、5周、6周大鼠脊髓运动诱发电位(scMEP)和肌肉运动诱发电位(mMEP),同时采用BBB评分对大鼠后肢运动功能进行评定. 6周后观察大鼠脊髓组织学结构变化.结果 实验组大鼠脊髓损伤后3 h scMEP波幅减小,为正常波幅的32.69% ± 0.83% ,2周后为正常波幅的52.93% ± 2.23%并处于稳定状态,但均低于对照组( P值均<0.01);损伤后3 h mMEP波形消失,1 d后恢复至正常波幅的1.16% ± 0.17% ,3 d后波幅明显恢复,4周后达正常波幅的48.20% ± 3.70%并处于稳定状态,但均低于对照组( P值均<0.01).实验组大鼠脊髓损伤后3 h和1 d,所有大鼠BBB评分均为0分,3 d后评分(1.38 ± 0.52)分,4周后评分(11.50 ± 0.93)分,达到稳定状态,但均低于对照组(P值均<0.01).实验组大鼠脊髓损伤后3 h~6周,scMEP与BBB评分均为显著相关(r值为0.732~0.908,P值均<0.05).实验组大鼠脊髓损伤后1~6周mMEP与BBB评分呈中度至高度相关(r值为0.718~0.951,P值均<0.05).对照组大鼠以上各指标均无显著变化.结论 大鼠脊髓损伤发生后,scMEP、mMEP和BBB评分三个脊髓功能指标会先后顺序恢复,而且 scMEP、 mMEP 与 BBB 评分均存在着一定的相关性.大鼠脊髓损伤后, scMEP、mMEP是较BBB评分更为灵敏的脊髓功能评价指标. 展开更多
关键词 脊髓损伤 诱发电位 运动 行为学检测 Basso-Beattie-Bresnahan评分 模型 动物 大鼠
女性“观看”与主体建构——解读安·贝蒂的《换挡》与《刻画威尔》 预览
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作者 黄姗姗 《广东第二师范学院学报》 2019年第1期62-67,共6页
凝视①是一种内蕴了权力的行为,父权社会中的女性通常活在有形或无形的男性凝视之下,安·贝蒂在许多作品中,都探讨了女性在凝视与反凝视的性别权力斗争中的命运。《换挡》和《刻画威尔》分别呈现了两位女主人公在与主体建构密切相... 凝视①是一种内蕴了权力的行为,父权社会中的女性通常活在有形或无形的男性凝视之下,安·贝蒂在许多作品中,都探讨了女性在凝视与反凝视的性别权力斗争中的命运。《换挡》和《刻画威尔》分别呈现了两位女主人公在与主体建构密切相关的“观看”方式方面的异同,从而走向了差异化的主体建构路径,反射出贝蒂对于女性该如何去“看”的思考。她反对女性挪用男性“观看”的方式,即精神的、理性的、内蕴权力等级的凝视,而提倡一种将肉身性也一并包含在视觉行为中的“观看”,以避免视觉中心主义以及理性的霸权,重新构建联结身心的主体性。 展开更多
关键词 女性"观看" 主体建构 安·贝蒂 《换挡》 《刻画威尔》
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Endothelial progenitor cell-conditioned medium promotes angiogenesis and is neuroprotective after spinal cord injury 预览
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作者 Tao Wang Xiao Fang Zong-Sheng Yin 《中国神经再生研究:英文版》 SCIE CAS CSCD 2018年第5期887-895,共9页
关键词 房间 媒介 祖先 绳索 损害 apoptosis 聚合酶链反应 VIVO
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大鼠脊髓钝挫伤后早期糖原合成酶激酶3β的表达及意义 预览
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作者 侯嘉兴 胡析 +8 位作者 刘世恒 孟颖桢 李盈洁 牛英杰 殷其勇 董梦影 郭海玲 张晓 冉黎 《四川医学》 CAS 2018年第1期16-20,共5页
目的研究大鼠脊髓钝挫损伤早期,脊髓损伤区域糖原合成酶激酶3-β(GSK3-β)的表达变化及细胞定位情况。探讨其在脊髓损伤(SCC)早期的生物学功能。方法将40只成年Sprague—Dawley(SD)大鼠随机分成假手术(Sham)组与SCC-12h、1d、3... 目的研究大鼠脊髓钝挫损伤早期,脊髓损伤区域糖原合成酶激酶3-β(GSK3-β)的表达变化及细胞定位情况。探讨其在脊髓损伤(SCC)早期的生物学功能。方法将40只成年Sprague—Dawley(SD)大鼠随机分成假手术(Sham)组与SCC-12h、1d、3d和7d组,每组各8只。除Sham组大鼠外均采用改良Allen’s法建立大鼠T10节段脊髓钝挫伤模型,用BBB评分评价各组大鼠的运动功能;采用荧光定量PCR(Q-PCR)及免疫组织化学法检测各组大鼠脊髓GSK3-β的表达情况,观察并统计不同时间点SCC组大鼠GSK3-β免疫组化阳性细胞的分布及数量变化。结果与Sham组相比,各SCC组大鼠BBB评分显著下降,术后第7d比第3d有所升高,差异有统计学意义(P〈0.01)。GSK3-βmRNA相对表达量于术后12h明显降低,至术后第3d再次降低。免疫组织化学检测各SCC组GSK3-β阳性细胞均比Sham组少,差异有统计学意义(P〈0.01),以SCC-3d组最少;脊髓灰质的GSK3-β阳性细胞主要在前角表达,其数量在SCC一12h组明显降低,术后第3d达到最低值,术后第7d明显升高,但仍然低于Sham组,差异有统计学意义(P〈0.05);脊髓后角GSK3-β阳性细胞表达较少,各组间比较差异无统计学意义(P〉0.05)。结论在维护脊髓正常功能中发挥重要作用;脊髓损伤后,机体通过调节GSK3-β的表达减轻炎症反应和促进损伤脊髓运动功能的恢复。 展开更多
关键词 糖原合成酶激酶3 脊髓损伤 荧光定量聚合酶链反应 免疫组织化学 Basso-Beattie—Bresnahan评分
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Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury 预览
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作者 Yan-Lei Wang Ying-Na Qi +5 位作者 Wei Wang Chun-Ke Dong Ping Yi Feng Yang Xiang-Sheng Tang Ming-Sheng Tan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2018年第7期1241-1246,共6页
关键词 解压缩 绳索 损害 容器 apoptosis 针灸 物品 电镀
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安·贝蒂《大大的外部世界》与海明威《雨中的猫》互文性研究 被引量:2
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作者 郭颖 《当代外国文学》 CSSCI 北大核心 2017年第3期66-72,共7页
安·贝蒂是当代美国文坛颇具影响力的女作家,"极简主义"小说的重要代表人物之一,其短篇小说《大大的外部世界》被学界认为深受欧内斯特·海明威《雨中的猫》的影响。安·贝蒂别具匠心地运用互文性手法,既从前文本中获取意... 安·贝蒂是当代美国文坛颇具影响力的女作家,"极简主义"小说的重要代表人物之一,其短篇小说《大大的外部世界》被学界认为深受欧内斯特·海明威《雨中的猫》的影响。安·贝蒂别具匠心地运用互文性手法,既从前文本中获取意义,同时又对现文本进行一定的改变,实现了文学传统的传承与创新。本文将两个文本置于互文性的视域下,从主题展现、角色关系、空间隐喻三个维度进行解读与分析。 展开更多
关键词 安·贝蒂 欧内斯特·海明威 主题展现 互文性
Globose basal cells for spinal cord regeneration 预览
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作者 Durai Murugan Muniswami Indirani Kanakasabapathy George Tharion 《中国神经再生研究:英文版》 SCIE CAS CSCD 2017年第11期1895-1904,共10页
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存在空虚、身体政治和女性主义—安·贝蒂短篇小说《换挡》解读 被引量:3
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作者 郭颖 王中强 《当代外国文学》 CSSCI 北大核心 2016年第1期44-51,共8页
安·贝蒂是当代美国重要短篇小说家,《纽约客》杂志著名撰稿人,曾与雷蒙德·卡佛、鲍比·安·梅森等"极简主义"作家一起推动了当代美国短篇小说的复兴。学界在评论安·贝蒂的作品时,不少是从"极简主义"角度进... 安·贝蒂是当代美国重要短篇小说家,《纽约客》杂志著名撰稿人,曾与雷蒙德·卡佛、鲍比·安·梅森等"极简主义"作家一起推动了当代美国短篇小说的复兴。学界在评论安·贝蒂的作品时,不少是从"极简主义"角度进行的。但需指出的是,安·贝蒂作品还有一个最重要的特征:它真实地反应了"婴儿潮一代"女性的生活状况和心理状态,这也是她经常被称为"时代代言人"的原因。《换挡》是安·贝蒂早期重要作品,主要描写了年轻女性娜塔莉婚后的家庭生活,入木三分地刻划了"婴儿潮一代"女性共有的存在空虚。不过,作者通过让娜塔莉逐渐感知自己身体、认知自我身份,使其形成了独立的自我意识。《换挡》一文的发表正值美国女权运动高涨之机,它映射了彼时美国年轻女性生活状况和心理状态的改变。 展开更多
关键词 安·贝蒂 《换挡》 存在空虚 身体政治 女性主义
施万细胞治疗大鼠创伤性脊髓损伤的Metaeta分析 被引量:3
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作者 卢腾 刘超 +3 位作者 董军 陆梦 康健 贺西京 《中国循证医学杂志》 CSCD 2015年第6期705-712,共8页
目的系统评价施万细胞(SCs)或激活态施万细胞(ASCs)移植对创伤性脊髓损伤(TSCI)大鼠运动功能的影响和安全性。方法计算机检索PubMed、EMbase、The Cochrane Library(2014年第12期)、CBM、EMbase、CNKI、Wan Fang Data和VIP数据... 目的系统评价施万细胞(SCs)或激活态施万细胞(ASCs)移植对创伤性脊髓损伤(TSCI)大鼠运动功能的影响和安全性。方法计算机检索PubMed、EMbase、The Cochrane Library(2014年第12期)、CBM、EMbase、CNKI、Wan Fang Data和VIP数据库,收集有关SCs或ASCs移植治疗大鼠TSCI的随机对照实验(RCT),检索时限均为建库至2014年12月。由2位研究者独立按纳入与排除标准筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果最终纳入14个RCT,共计510只大鼠。Meta分析结果显示:单用SCs或ASCs移植术后4周[SMD=2.31,95%CI(1.48,3.13),P〈0.000 01]、8周[SMD=3.93,95%CI(3.06,4.81),P〈0.000 01]、12周[SMD=6.15,95%CI(4.30,8.00),P〈0.000 01]的BBB评分优于对照组。SCs或ASCs联合其他治疗方法移植术后4周[SMD=1.06,95%CI(0.44,1.68),P=0.000 8]、8周[SMD=2.26,95%CI(1.57,2.96),P〈0.000 01]、12周[SMD=1.49,95%CI(0.72,2.25),P〈0.000 01]的BBB评分优于单用其他治疗方法。ASCs移植组在术后4周[SMD=4.31,95%CI(3.50,5.13),P〈0.000 01]、12周[SMD=5.44,95%CI(3.99,6.89),P〈0.000 01]的BBB评分优于SCs移植组。移植组和对照组死亡率的差异无统计学意义。结论当前证据表明,SCs和ASCs移植可提高TSCI大鼠运动功能,且安全性高。ASCs较SCs具有更强的修复能力。受纳入研究质量限制,上述结论尚需开展更多大样本、高质量的RCT来加以验证。 展开更多
关键词 脊髓损伤 施万细胞 移植 BBB评分 大鼠 META分析
Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury 预览
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作者 Jian-long Wang Qing-shan Zhang +4 位作者 Kai-di Zhu Jian-feng Sun Ze-peng Zhang Jian-wen Sun Ke-xiang Zhang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2015年第6期958-964,共7页
Hydrogen can relieve tissue-damaging oxidative stress, inflammation and apoptosis. Injection of hydrogen-rich saline is an effective method for transporting molecular hydrogen. We hypothesized that hydrogen-rich salin... Hydrogen can relieve tissue-damaging oxidative stress, inflammation and apoptosis. Injection of hydrogen-rich saline is an effective method for transporting molecular hydrogen. We hypothesized that hydrogen-rich saline would promote the repair of spinal cord injury induced by Allen’s method in rats. At 0.5, 1, 2, 4, 8, 12 and 24 hours after injury, then once daily for 2 weeks, 0.25 m L/kg hydrogen-rich saline was infused into the subarachnoid space through a catheter. Results at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration, serum malondialdehyde content, and caspa se-3 immunoreactivity, elevated serum superoxide dismutase activity and calcitonin gene-related peptide immunoreactivity, and improved motor function in the hindlimb. The present study confirms that hydrogen-rich saline injected within 2 weeks of injury effectively contributes to the repair of spinal cord injury in the acute stage. 展开更多
关键词 急性脊髓损伤 生理盐水 蛛网膜下腔 盐水注射 含氢 超氧化物歧化酶活性 降钙素基因相关肽 免疫反应性
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Electroacupuncture promotes the recovery of motor neuron function in the anterior horn of the injured spinal cord 预览 被引量:1
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作者 Jian-hui Yang Jian-guo Lv +1 位作者 Hui Wang Hui-yong Nie 《中国神经再生研究:英文版》 SCIE CAS CSCD 2015年第12期2033-2039,共7页
Acupuncture has been shown to lessen the inflammatory reaction after acute spinal cord injury and reduce secondary injury.However,the mechanism of action remains unclear.In this study,a rat model of spinal cord injury... Acupuncture has been shown to lessen the inflammatory reaction after acute spinal cord injury and reduce secondary injury.However,the mechanism of action remains unclear.In this study,a rat model of spinal cord injury was established by compressing the T8–9 segments using a modified Nystrom method.Twenty-four hours after injury,Zusanli(ST36),Xuanzhong(GB39),Futu(ST32)and Sanyinjiao(SP6)were stimulated with electroacupuncture.Rats with spinal cord injury alone were used as controls.At 2,4 and 6 weeks after injury,acetylcholinesterase(ACh E)activity at the site of injury,the number of medium and large neurons in the spinal cord anterior horn,glial cell line-derived neurotrophic factor(GDNF)m RNA expression,and Basso,Beattie and Bresnahan locomotor rating scale scores were greater in the electroacupuncture group compared with the control group.These results demonstrate that electroacupuncture increases ACh E activity,up-regulates GDNF m RNA expression,and promotes the recovery of motor neuron function in the anterior horn after spinal cord injury. 展开更多
关键词 急性脊髓损伤 运动神经元 脊髓前角 电针刺激 胶质细胞源性神经营养因子 乙酰胆碱酯酶 mRNA表达 GDNF
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注射硫酸软骨素酶对大鼠脊髓损伤后腓肠肌乙酰胆碱酯酶的变化及运动功能的影响 预览 被引量:1
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作者 李洪鹏 白旭东 +2 位作者 高杰 巴方 刘宁 《中国康复理论与实践》 CSCD 北大核心 2012年第3期 219-221,共3页
目的探讨注射硫酸软骨素酶ABC对成年大鼠脊髓损伤后不同时期后肢运动功能的恢复及腓肠肌运动终板内乙酰胆碱酯酶的影响。方法 10周龄Wistar雄性大鼠40只,采用脊髓半横断法制作模型,健侧作为对照组(A组),患侧随机分为单纯脊髓损伤组(... 目的探讨注射硫酸软骨素酶ABC对成年大鼠脊髓损伤后不同时期后肢运动功能的恢复及腓肠肌运动终板内乙酰胆碱酯酶的影响。方法 10周龄Wistar雄性大鼠40只,采用脊髓半横断法制作模型,健侧作为对照组(A组),患侧随机分为单纯脊髓损伤组(B组)及术后注射硫酸软骨素酶ABC组(C组)。术后采用BBB评分法进行行为学观察,分别于损伤后3 d、7 d、14 d和28d各选取5只大鼠,酶化学染色法检测腓肠肌中乙酰胆碱酯酶(AChE)的表达。结果 C组在术后14~28 d BBB评分高于B组(P〈0.05);B组和C组与A组相比,腓肠肌AChE活性均降低,但C组于术后14~28 d AchE活性高于B组(P〈0.05)。结论大鼠脊髓损伤后注射硫酸软骨素酶可以提高AChE的活性,并可提高大鼠患肢的运动功能。 展开更多
关键词 脊髓损伤 硫酸软骨素酶 BBB评分 乙酰胆碱酯酶 大鼠
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