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Fungal-contaminated grass and well water and sporadic amyotrophic lateral sclerosis 预览
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作者 Peter William French Russell Ian Ludowyke Gilles J.Guillemin 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1490-1493,共4页
Fungi are important infectious disease-causing agents,but are often overlooked as environmental factors in disease.We review several lines of evidence that point to a potential fungal origin of sporadic amyotrophic la... Fungi are important infectious disease-causing agents,but are often overlooked as environmental factors in disease.We review several lines of evidence that point to a potential fungal origin of sporadic amyotrophic lateral sclerosis(ALS),the most common form of motor neurone disease.Approximately 90%cases of ALS are sporadic,and the aetiology of sporadic ALS is still unknown.We have previously postulated that grass or soil-associated fungal infections may be a leading cause of sporadic ALS.Herein we extend this proposal to water-associated fungi.A wide variety of fungi have been reported in drinking water including Acremonium,Alternaria,Aspergillus,Cladosporium,Fusarium,Penicillium and Trichoderma.Some of these are known to produce neurotoxic mycotoxins.Despite this,drinking water is not routinely monitored for fungal contamination.Fungal contamination could explain the close correlation between distribution of well water and cases of sporadic ALS in the United States.We propose several mechanisms by which an opportunistic fungal infection from environmental exposure(to water,soil or plants)can lead to long term neuronal degradation resulting in the hallmarks of ALS.If confirmed,the association between fungal infection and sporadic ALS could lead to novel treatment strategies for this progressive and fatal disease. 展开更多
关键词 amyotrophic lateral SCLEROSIS fungi motor neurone disease mycotoxins NEUROTOXINS ALS well water SPORADIC ALS
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过表达OsALSC512A基因拟南芥对几种除草剂抗性的研究
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作者 辛洁 胡健立 +8 位作者 张红磊 高晨旭 刘菲 张融雪 苏京平 孙玥 朱晔荣 刘学军 王勇 《南开大学学报:自然科学版》 CAS CSCD 北大核心 2019年第4期99-106,共8页
以乙酰乳酸合酶(ALS)为靶标的除草剂是目前生产中应用较为广泛的除草剂,具有用量少、选择性强、杀草谱广、生物活性高,对哺乳动物毒性低的特点.本研究对水稻ALS编码基因进行了定点突变,获得了突变基因OsALSC512A,实现了第171位脯氨酸残... 以乙酰乳酸合酶(ALS)为靶标的除草剂是目前生产中应用较为广泛的除草剂,具有用量少、选择性强、杀草谱广、生物活性高,对哺乳动物毒性低的特点.本研究对水稻ALS编码基因进行了定点突变,获得了突变基因OsALSC512A,实现了第171位脯氨酸残基成为组氨酸残基(Pro171His);然后构建了其过表达载体,并转化拟南芥进行了除草剂抗性检测.对分属四类的四种除草剂的生测结果显示,突变后的水稻ALS赋予了转基因拟南芥对双草醚、甲基二磺隆和五氟磺草胺的抗性,但是没有赋予对普施特的抗性.研究结果对于进一步开展水稻抗ALS靶标除草剂的基因编辑以及获得抗除草剂新种质有一定的指导意义. 展开更多
关键词 水稻 除草剂抗性 ALS 点突变 拟南芥
基于交替最小二乘法和规则匹配的菜品推荐 预览
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作者 金琪文 王先传 +2 位作者 彭亮 王顺杰 陈秀明 《阜阳师范学院学报:自然科学版》 2019年第3期49-54,共6页
随着大数据时代的来临,餐饮行业的蓬勃发展,菜品的多样化,使得越来越多的人陷入了选择上的困难境地。为此,本文提出基于交替最小二乘法的菜品推荐,并使用规则匹配算法对得到的推荐列表进行优化以满足不同用户的膳食搭配和特殊需求。实... 随着大数据时代的来临,餐饮行业的蓬勃发展,菜品的多样化,使得越来越多的人陷入了选择上的困难境地。为此,本文提出基于交替最小二乘法的菜品推荐,并使用规则匹配算法对得到的推荐列表进行优化以满足不同用户的膳食搭配和特殊需求。实验结果表明,该方法的推荐结果具有较小的均方根误差,可以在一定程度上满足用户在喜好、健康、营养均衡