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鼻部超短波对儿童慢性鼻-鼻窦炎的治疗效果 认领
1
作者 郑书希 《中国继续医学教育》 2021年第1期141-144,共4页
目的探究分析鼻部超短波治疗儿童慢性鼻-鼻窦炎的治疗效果。方法选取本院收治的共计200名慢性鼻-鼻窦炎小儿患者作为试验研究对象,将所有的患者按照电脑随机分配的方式分为对照组和观察组,其中对照组人数共计100名,在临床上采用常规传... 目的探究分析鼻部超短波治疗儿童慢性鼻-鼻窦炎的治疗效果。方法选取本院收治的共计200名慢性鼻-鼻窦炎小儿患者作为试验研究对象,将所有的患者按照电脑随机分配的方式分为对照组和观察组,其中对照组人数共计100名,在临床上采用常规传统治疗方式进行,观察组人数共计100名,在临床上主要采用鼻部超短波治疗方式进行。对比两组患者在整体的治疗效果,患者的满意度、患者术后的并发症发生情况等。结果患者在治疗完成之后,观察组的整体鼻-鼻窦炎治疗效果显著高于对照组,完全治愈的患者共计55名,部分治愈患者共计42名,治愈率达到了97%,而对照组患者完全治愈患者32名,部分治愈患者32名,治愈率为64%,差异具有统计学意义(P<0.05),同时从观察组的治疗满意度以及术后并发症方面来看,观察组患者显著高于对照组,且差异具有统计学意义(P<0.05)。结论在当前阶段针对小儿鼻-鼻窦炎来说,通过实施有效的鼻部超短波方式相比于常规治疗方式具有更高的治疗价值,同时治疗安全性显著提升,降低了临床并发症的发生。 展开更多
关键词 鼻部超短波 治疗方式 鼻窦炎 小儿患者 对比分析 治疗效果
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肛肠外科术后常见并发症中医辨证论治的应用体会研究 认领
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作者 赵志伟 《中国社区医师》 2021年第3期133-134,共2页
目的:研究将中医辨证论治应用于肛肠外科术后常见并发症的作用与效果。方法:选取2018年2月-2020年2月实施肛肠外科手术的患者54例,术后均出现不同类型的常见并发症;随机分为两组,各27例。针对不同类型的并发症,对照组实施常规治疗,观察... 目的:研究将中医辨证论治应用于肛肠外科术后常见并发症的作用与效果。方法:选取2018年2月-2020年2月实施肛肠外科手术的患者54例,术后均出现不同类型的常见并发症;随机分为两组,各27例。针对不同类型的并发症,对照组实施常规治疗,观察组实施中医辨证论治,比较两组治疗效果。结果:观察组治疗总有效率(96.30%)明显高于对照组(77.78%),差异有统计学意义(P<0.05)。结论:中医辨证论治应用于肛肠外科术后出现并发症的患者,能够获得更为理想的治疗效果。 展开更多
关键词 肛肠外科 治疗 并发症 效果 中医辨证论治 手术
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文章速递Adenoid Cystic Carcinoma Invade the Tracheal Prominence: A Case Report and Literature Review 认领
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作者 Kaiwen He Haitao Huang +2 位作者 Shaomu Chen Yu Feng Haitao Ma 《临床医学病理报告(英文)》 2021年第1期8-16,共9页
<strong>Background: </strong>Adenoid cystic carcinoma (ACC) refers to a salivary gland neoplasm. Tracheal adenoid cystic carcinoma that invades the tracheal prominence is a relatively rare tumor among thor... <strong>Background: </strong>Adenoid cystic carcinoma (ACC) refers to a salivary gland neoplasm. Tracheal adenoid cystic carcinoma that invades the tracheal prominence is a relatively rare tumor among thoracic diseases.<strong> Objective: </strong>To explore the epidemiology, diagnosis, treatment and future development of tracheal adenoid cystic carcinoma (TACC). <strong>Methods:</strong> With asymptomatic invasion of the tracheal prominence, a case of tracheal adenoid cystic carcinoma with asymptomatic invasion of the tracheal prominence was reported. The clinical management process and surgical methods were introduced, and related literature was reviewed and summarized. <strong>Results: </strong>The patient was admitted due to tracheal augmentation mass for half a month. Chest CT at admission displayed the soft tissue density shadow behind the tracheal augmentation process. After the completion of other examinations, tracheal tumor resection and tracheal reconstruction were performed. Postoperative routine pathology exhibited that it was TACC and without inguinal lymph node metastasis. <strong>Conclusion:</strong> TACC is a low-grade tracheal tumor with low incidence, delayed clinical manifestations and lack of specificity as well. CT and bronchoscopy are helpful for the diagnosis of suspected patients. Meanwhile, radical surgical resection is the first choice of treatment. Adjuvant therapy can improve the therapeutic effect. Targeted immunotherapy is the developing direction of treatment. 展开更多
关键词 Tracheal Adenoid Cystic Carcinoma Diagnosis Treatment
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文章速递Inhibitory Effect of Histone Deacetylase Inhibitor on the Proliferation of Leukemia Cells and Its Anti-Tumor Pharmacology 认领
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作者 Shubo Wang 《生物科学与医学(英文)》 2021年第1期30-40,共11页
The aim of this study was to explore the inhibitory effect of histone deacetylase inhibitor (HDACI) on the proliferation of leukemia cells. The two kinds of leukemia cells (human promyelocytic leukemia cell (HL-60) an... The aim of this study was to explore the inhibitory effect of histone deacetylase inhibitor (HDACI) on the proliferation of leukemia cells. The two kinds of leukemia cells (human promyelocytic leukemia cell (HL-60) and human acute myelogenous leukemia cell (KG-1)) were selected for in vitro research. Besides, Chidamide, a kind of benzamide HDACI, was applied to induce and culture the HL-60 and KG-1 cells, and the anti-tumor cell proliferation activity of Chidamide on HL-60 and KG-1 was detected by the methyl thiazolyl tetrazolium (MTT) assay, which was 5.6 and 6.1 in turn. The cell scratch experiment verified that Chidamide had the metastasis inhibitory effect on HL-60 and KG-1 cells. Flow cytometry was employed to measure the percentage of apoptotic cells, and it was found that the percentage of apoptotic cells was 55.6% ± 1% and 48.6% ± 1% in sequence after HL-60 and KG-1 cells were treated with Chidamide for 36 hours. The number of auto-phagosomes was determined by transmission electron microscopy showing that the number of auto-phagosomes in HL-60 and KG-1 cells was 12 ± 1 and 10 ± 1, respectively after the induction process of Chidamide. The phosphorylated histone H2AX protein (γ-H2AX) recognition antibody immunofluorescence method was adopted to determine the deoxyribonucleic acid (DNA) damage, and the positive rates of HL-60 and KG-1 cells reached 28.41% and 26.35%, respectively after Chidamide treatment. Therefore, Chidamide, as a kind of HDACI, could effectively inhibit the proliferation of leukemia cells, so that the results of this experiment had a good guiding meaning for the clinical diagnosis and treatment of leukemia. 展开更多
关键词 Tumor Cell Proliferation Histone Deacetylase Inhibitor Chidamide Leukemia Treatment
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文章速递Commentary: “Ockham’s Razor” Doesn’t Apply to “Opioid” Overdose Death 认领
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作者 John F. Peppin Joseph V. Pergolizzi Jr. +1 位作者 Eugene Vortsman Robert B. Raffa 《生物科学与医学(英文)》 2021年第1期98-104,共7页
Polysubstance Abuse (PSA) greatly complicates an attempt to implicate a single drug as sole cause of an overdose death. Since PSA now occurs in the majority of cases of drug overdoses, many or most overdose deaths are... Polysubstance Abuse (PSA) greatly complicates an attempt to implicate a single drug as sole cause of an overdose death. Since PSA now occurs in the majority of cases of drug overdoses, many or most overdose deaths are polysubstance overdose deaths. And since many of the substances involved in a polysubstance Overdose Death (POD) are Central Nervous System (CNS) depressants, many of which can cause overdose death themselves, or synergistically with opioids, it is somewhat puzzling that prescription opioids have been singled out as the cause of these deaths—without reference to PSA. This is particularly puzzling in light of the fact that the issues of PSA and POD have been recognized and discussed in the literature since at least the 1960’s and before. We therefore here consider the question: are we facing an “opioid” crisis or, instead, a “polysubstance crisis”? And we wonder if the issue has been over-simplified, to the detriment of the individuals affected, and to society more broadly. There is a need for an “agnostic” respiratory stimulant that can reverse polysubstance-induced respiratory depression. 展开更多
关键词 Opioid Overdose Polysubstance Use Polysubstance Overdose Treatment
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文章速递Ossified Subdural Chronic Hematoma: Two Cases Report and Literature Review 认领
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作者 K. Quenum O. H. Fatigba +3 位作者 O. Coulibaly Y. P. Houndje C. Tchegnonsi B. Quenum 《现代神经外科学进展(英文)》 2021年第1期29-33,共5页
Ossified subdural chronic hematoma (OSCH) is a rare disease that accounts 0.3% to 2% of subdural chronic hematoma which is common. The surgical management depends on his clinical expression. The aim of this study is t... Ossified subdural chronic hematoma (OSCH) is a rare disease that accounts 0.3% to 2% of subdural chronic hematoma which is common. The surgical management depends on his clinical expression. The aim of this study is to highlight the surgical procedure because the management of this type of lesion has no consensus. The authors reported two cases of OSCH which were successfully excised with good outcomes. Taking care during the procedure of dissection from parenchyma is the key for this surgery. 展开更多
关键词 Ossified Subdural Chronic Hematoma Calcified Subdural Chronic Hematoma Chronic Hematoma Surgical Treatment
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文章速递Spontaneous External Digestive Fistula of Tuberculosis Origin, Medical Treatment: About a Case at the Timbuktu Hospital 认领
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作者 Oumar Ongoïba Idrissa Tounkara +4 位作者 Thiam Souleymane Charles Dara Jacques Saye Karim Dao Djibril Kassogué 《外科学(英文)》 2021年第1期17-22,共6页
In the literature, the management of enterocutaneous fistula of tuberculosis origin is rare. The aim of this work was to report a case of external digestive fistula of tuberculosis origin in a 10-year-old girl in nort... In the literature, the management of enterocutaneous fistula of tuberculosis origin is rare. The aim of this work was to report a case of external digestive fistula of tuberculosis origin in a 10-year-old girl in northern Mali in a situation of armed conflict. She was a 10-year-old patient who was admitted to our general surgery ward for external digestive fistula evolving for more than (4) four years, at admission the general. The karnofsky index was at 40%, she could not sit or hold a cup to drink water. A 3 cm enterocutaneous fistula deafened foul-smelling liquid stools, on clinical examination, the conjunctivas were pale, the lips were dry, the eyes were sunk in the eye sockets, the ribs visible from a distance. The paraclinical aspects (<em>Itra-Dermo-Reaction</em> (IDR) to <em>tubercria</em>, anatomopathology) were positive, specifying the place of medical treatment and evolution under medical treatment. Digestive fistula of tuberculosis origin is a rare condition in surgical settings. 展开更多
关键词 Spontaneous External Digestive Fistula Non-Surgical Treatment Timbuktu
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文章速递The Evaluation Characteristics of Type B Aortic Intramural Hematoma and Ten Years Treatment Outcomes 认领
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作者 Jinguo Zhu Hongbo Hu 《心血管病(英文)》 2021年第1期58-68,共11页
<strong>Background</strong><strong>:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Type B aortic</span><b&... <strong>Background</strong><strong>:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Type B aortic</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">intramural hematoma (IMH-B) is recognized as a subset of aortic dissection. The evolution of uncomplicated IMH-B is very difficult to predict. How and when to deal with this disease is unclear. The present study constructed two models to explore this problem. One is the</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">morphology evolution model, which explored the risk factors and predictors for the IMH-B patients. Another is the predictive model confirmed the predictors and the time for invasive treatment of uncomplicated IMH-B patients.</span></span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Objective: </span></b><span style="font-family:Verdana;">To explore the evolution predictors and detect the time for invasive treatment of uncomplicated IMH-B patients.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:;" "=""><span style="font-family:Verdana;">The</span><b></b><span style="font-family:Verdana;">morphology evolution model demonstrated that all 81 patients were diagnosis with CTA images. The initial and follow-up data were retrospectively studied. The evolution data were collection and measurement from initial and follow-up CTA images data. The predictive model showed that predictors of progression were detected with cox regression analysis.</span></span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">All 81IMH-B patients were followed-up ranged from 1.2 to 36 months (median, 22 months). 26 patients accepted invasive treatment (24 underwent TEVAR and 2 underwent Surgery)</span><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;">55 patients received medical treatment. Invasive treatment (IT) group overall events </span><span style="font-family:Verdana;">are </span><span style="font-family:Verdana;">1</span><span style="font-family:Verdana;">/</span><span style="font-family:Verdana;">26 (3.8%)</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> medical treatment</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">(MT) group overall events </span><span style="font-family:Verdana;">are </span><span style="font-family:Verdana;">33</span><span style="font-family:Verdana;">/</span><span style="font-family:Verdana;">55 (60.0%)</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> IT group</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">vs.</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">MT group</span><span style="font-family:Verdana;">:</span><span style="font-family:Verdana;"> p < 0.001</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> Moreover,</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">we found that most events related aorta occurred within 30 days. Multivariate Cox regression analysis MDAD (hazard ratio, 3.58;95% CI, 1.25</span><span style="font-family:;" "=""></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">5.78;p < 0.001), MDAHT (hazard ratio, 4.26;95% CI, 0.85</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">7.84;p < 0.001), and IMH with PAU (hazard ratio, 3.58;95% CI, 1.02</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">5.63;p < 0.001) were confirmed as the independent predictors. </span><b><span style="font-family:Verdana;">Conclusions: </span></b><span style="font-family:Verdana;">MDAD > 45 mm, MDAHT > 10</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">mm, and IMH with PAU may be the important predictors for uncomplicated IMH-B patients. Most adverse aorta related events occurred within 30 days. It would be careful follow-up, closely observe for these patients within 30 days, and take necessary treatment strategies in time.</span> 展开更多
关键词 IMH-B Aortic Related Events Treatment Strategies
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Alpl基因影响骨髓间充质干细胞治疗溃疡性结肠炎 认领
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作者 张立书 刘安琪 +3 位作者 何小宁 金岩 李蓓 金钫 《中国组织工程研究》 CAS 北大核心 2021年第25期3970-3975,共6页
背景:骨髓间充质干细胞移植治疗溃疡性结肠炎已取得显著疗效,但是其具体作用机制尚未完全阐明。目的:观察并探讨Alpl基因对骨髓间充质干细胞治疗溃疡性结肠炎的影响。方法:①饲养并繁殖Alpl~(+/-)小鼠与野生型小鼠,进行基因型鉴定;②体... 背景:骨髓间充质干细胞移植治疗溃疡性结肠炎已取得显著疗效,但是其具体作用机制尚未完全阐明。目的:观察并探讨Alpl基因对骨髓间充质干细胞治疗溃疡性结肠炎的影响。方法:①饲养并繁殖Alpl~(+/-)小鼠与野生型小鼠,进行基因型鉴定;②体外培养Alpl~(+/-)小鼠和野生型小鼠的骨髓间充质干细胞,观察细胞生长情况,成骨分化实验和流式细胞仪检测细胞表面标记物进行干细胞鉴定;③将24只C57BL/6小鼠随机分为正常组、模型对照组、野生型小鼠骨髓间充质干细胞治疗组、Alpl~(+/-)小鼠骨髓间充质干细胞治疗组,后3组给予3%葡聚糖硫酸钠水溶液饲喂7 d诱导小鼠溃疡性结肠炎模型,2个治疗组小鼠在喂葡聚糖硫酸钠溶液第3天和第5天时分别尾静脉注射野生型小鼠或Alpl~(+/-)小鼠来源的骨髓间充质干细胞,第10天处死取结肠组织;④记录每日体质量变化并计算疾病活动指数,比较结肠长度,苏木精-伊红染色观察比较结肠黏膜的组织学变化。结果与结论:①基因型鉴定结果示杂合子为双条带,与美国杰克逊实验室提供的预测结果一致,提示成功繁育Alpl~(+/-)小鼠;②两组细胞均能形成红棕色的成骨结节,且均表达间充质干细胞表面标记物CD146和CD73,但相较于野生型来源骨髓间充质干细胞,Alpl~(+/-)小鼠来源骨髓间充质干细胞形态多样,缺乏边界清晰的长梭形细胞;③与模型对照组小鼠相比,2个治疗组小鼠肠炎症状和病理变化均减轻,但野生型小鼠骨髓间充质干细胞组的治疗效果明显优于Alpl~(+/-)小鼠骨髓间充质干细胞组;④结果提示,骨髓间充质干细胞移植能够治疗葡聚糖硫酸钠诱导的溃疡性结肠炎,且Alpl基因半敲除抑制骨髓间充质干细胞对溃疡性结肠炎的治疗效果。 展开更多
关键词 干细胞 骨髓间充质干细胞 溃疡性结肠炎 基因敲除 碱性磷酸酶 治疗 小鼠
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建筑施工中的地基施工处理技术分析 认领
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作者 杨玉忠 刘万利 《中小企业管理与科技》 2021年第5期174-175,共2页
在近几年的发展中,建筑工程在我国的发展越来越完善,人们在建筑上的需求逐渐增高,不仅注重建筑的质量,在美观上也要更加有创新性。以此,为加强对建筑工程的实施,地基施工处理技术是建筑的重要组成部分,在提升建筑工程发展时,地基施工处... 在近几年的发展中,建筑工程在我国的发展越来越完善,人们在建筑上的需求逐渐增高,不仅注重建筑的质量,在美观上也要更加有创新性。以此,为加强对建筑工程的实施,地基施工处理技术是建筑的重要组成部分,在提升建筑工程发展时,地基施工处理技术起着至关重要的作用,这直接影响着整个工程的发展。 展开更多
关键词 建筑 施工 地基 处理
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超声评估子宫内膜癌肌层浸润深度的研究进展 认领
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作者 张敏(综述) 覃伶伶(审校) 《海南医学》 CAS 2021年第2期250-253,共4页
肌层浸润深度是子宫内膜癌手术方案选择及病理分期的主要依据,是影响子宫内膜癌手术预后的最重要的独立因素。目前临床多应用超声检查、计算机断层扫描和磁共振成像等作为子宫内膜癌术前分期的工具。其中,又以超声检查应用最为广泛。本... 肌层浸润深度是子宫内膜癌手术方案选择及病理分期的主要依据,是影响子宫内膜癌手术预后的最重要的独立因素。目前临床多应用超声检查、计算机断层扫描和磁共振成像等作为子宫内膜癌术前分期的工具。其中,又以超声检查应用最为广泛。本文就常规经阴道二维超声、三维超声、超声造影、超声弹性成像等各种超声检查在评估子宫内膜癌肌层浸润深度方面的应用作一综述。 展开更多
关键词 子宫内膜癌 肌层浸润深度 超声检查 诊断 治疗 进展
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腹腔镜胆总管探查取石和胆管一期缝合术后胆瘘的防治策略 认领
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作者 牟秀芳 丁建华 +5 位作者 王强 孔新亮 高君 柯山 王向涛 孙文兵 《中国医刊》 CAS 2021年第2期150-153,共4页
目的探讨腹腔镜胆总管探查取石(laparoscopic common bile duct exploration,LCBDE)和胆管一期缝合(primary duct closure,PDC)术后胆瘘的防治策略。方法回顾性总结2016年3月至2020年6月多中心应用LCBDE+PDC治疗的217例胆总管结石患者... 目的探讨腹腔镜胆总管探查取石(laparoscopic common bile duct exploration,LCBDE)和胆管一期缝合(primary duct closure,PDC)术后胆瘘的防治策略。方法回顾性总结2016年3月至2020年6月多中心应用LCBDE+PDC治疗的217例胆总管结石患者的病例资料,其中男93例,女124例,年龄34~89岁,中位年龄44岁;胆管切开部位最大直径7~19mm,平均(11.8±2.1)mm;胆管前壁纵行切开183例,经胆囊管微切开34例。分析其胆瘘的发生原因及防治措施。结果217例患者手术成功率为100%,结石完全取出率为99.5%(216/217)。术后胆瘘发生率为10.1%(22/217)。胆瘘发生时间:术后3~5d 14例,6~7d 5例,8~10d 2例,术后40d 1例。每天最大瘘量:<50ml 12例,50~99ml 4例,100~199ml 2例,200~500ml 2例,700ml 1例,不详1例。胆瘘的分级和治疗:20例为A级,经保守治疗后痊愈;1例胆管下段残留结石于术后42d再次手术;1例抗心磷脂抗体综合征患者术后40d发生自发性胆瘘和弥漫性腹膜炎,经腹腔穿刺引流后痊愈。术后随访3~65个月,结石再发5例(2.3%),4例经逆行胰胆管造影术取出,1例行腹腔镜下Roux-en-Y胆肠吻合术治疗;无胆管狭窄、胆道疾病相关性死亡等远期并发症发生。结论通过系统的防治策略,可将胆总管结石LCBDE+PDC术后胆瘘发生率控制在较低水平,且多数胆瘘可通过保守治疗在短期内痊愈。 展开更多
关键词 胆总管结石 胆管探查取石 腹腔镜 一期缝合 胆瘘 预防 治疗
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小体积前列腺增生的微创外科治疗进展 认领
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作者 柴硕 王磊 +2 位作者 陈曦 曹凤宏 李晓强(审校) 《中国煤炭工业医学杂志》 2021年第1期108-112,共5页
良性前列腺增生(BPH)是中老年男性常见的疾病,目前主要的手术方式有经尿道前列腺电切术、激光手术、经尿道前列腺柱状水囊扩开术、前列腺动脉栓塞术、前列腺尿道悬吊术及新兴的经尿道前列腺机器人水刀切除术等,越来越多技术和观念都侧... 良性前列腺增生(BPH)是中老年男性常见的疾病,目前主要的手术方式有经尿道前列腺电切术、激光手术、经尿道前列腺柱状水囊扩开术、前列腺动脉栓塞术、前列腺尿道悬吊术及新兴的经尿道前列腺机器人水刀切除术等,越来越多技术和观念都侧重于安全性、提高生活质量、减少远期并发症,来满足不同患者的需求。小体积前列腺增生手术治疗存在较多争议,基于小体积前列腺治疗存在的诸多问题,本文就目前外科治疗小体积前列腺增生症的微创治疗作一简要综述,以期为临床上小体积前列腺增生手术方式选择提供参考。 展开更多
关键词 良性前列腺增生 小体积 手术 治疗
慢性软组织疼痛的诊断与治疗进展 认领
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作者 董宏然 汪鹏 陈松华 《中国疗养医学》 2021年第2期127-130,共4页
慢性软组织疼痛由软组织损害引起,是临床疼痛性疾病中最常见且最难治的临床病症,其临床表现复杂。根据软组织疼痛病灶部位的不同,临床按解剖分型,将软组织疼痛分为椎管外、椎管内、椎管内外混合型三种不同类型,其临床表现及诊断和治疗... 慢性软组织疼痛由软组织损害引起,是临床疼痛性疾病中最常见且最难治的临床病症,其临床表现复杂。根据软组织疼痛病灶部位的不同,临床按解剖分型,将软组织疼痛分为椎管外、椎管内、椎管内外混合型三种不同类型,其临床表现及诊断和治疗的方法也不同。本研究对椎管外软组织损害性慢性疼痛的诊断和治疗相关进展进行论述。 展开更多
关键词 慢性软组织疼痛 椎管外 诊断 治疗
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Cortical plasticity and nerve regeneration after peripheral nerve injury 认领
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作者 Ci Li Song-Yang Liu +1 位作者 Wei Pi Pei-Xun Zhang 《中国神经再生研究:英文版》 SCIE CAS 2021年第8期1518-1523,共6页
With the development of neuroscience, substantial advances have been achieved in peripheral nerve regeneration over the past decades. However, peripheral nerve injury remains a critical public health problem because o... With the development of neuroscience, substantial advances have been achieved in peripheral nerve regeneration over the past decades. However, peripheral nerve injury remains a critical public health problem because of the subsequent impairment or absence of sensorimotor function. Uncomfortable complications of peripheral nerve injury, such as chronic pain, can also cause problems for families and society. A number of studies have demonstrated that the proper functioning of the nervous system depends not only on a complete connection from the central nervous system to the surrounding targets at an anatomical level, but also on the continuous bilateral communication between the two. After peripheral nerve injury, the interruption of afferent and efferent signals can cause complex pathophysiological changes, including neurochemical alterations, modifications in the adaptability of excitatory and inhibitory neurons, and the reorganization of somatosensory and motor regions. This review discusses the close relationship between the cerebral cortex and peripheral nerves. We also focus on common therapies for peripheral nerve injury and summarize their potential mechanisms in relation to cortical plasticity. It has been suggested that cortical plasticity may be important for improving functional recovery after peripheral nerve damage. Further understanding of the potential common mechanisms between cortical reorganization and nerve injury will help to elucidate the pathophysiological processes of nerve injury, and may allow for the reduction of adverse consequences during peripheral nerve injury recovery. We also review the role that regulating reorganization mechanisms plays in functional recovery, and conclude with a suggestion to target cortical plasticity along with therapeutic interventions to promote peripheral nerve injury recovery. 展开更多
关键词 cortical plasticity INJURY MECHANISMS nerve transfer NEURORRHAPHY peripheral nerve phantom limb pain RECOVERY REGENERATION treatment
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间充质干细胞治疗溃疡性结肠炎:可能与可行 认领
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作者 梁园 江小柯 +2 位作者 白阳秋 罗晓英 张炳勇 《中国组织工程研究》 CAS 北大核心 2021年第25期4065-4069,共5页
背景:溃疡性结肠炎是一种由免疫紊乱介导而造成的肠道慢性非特异性炎症性疾病,随着病程延长,癌变发生率迅速增加。近年来,溃疡性结肠炎发生率逐年上升,发病年龄趋于年轻化,但传统的治疗方案对部分患者效果欠佳。间充质干细胞是一种具有... 背景:溃疡性结肠炎是一种由免疫紊乱介导而造成的肠道慢性非特异性炎症性疾病,随着病程延长,癌变发生率迅速增加。近年来,溃疡性结肠炎发生率逐年上升,发病年龄趋于年轻化,但传统的治疗方案对部分患者效果欠佳。间充质干细胞是一种具有强大自我更新、多向分化、低免疫原性和调节免疫功能的细胞,相关的动物和临床研究表明,间充质干细胞治疗溃疡性结肠炎安全有效,但多数研究的样本量较少。目的:总结溃疡性结肠炎的流行病学特征和治疗现状,展望间充质干细胞治疗溃疡性结肠炎的临床应用前景。方法:检索中国知网、万方和PubMed、GreenMedical数据库,以"炎症性肠病,溃疡性结肠炎,间充质干细胞,inflammatory bowel disease,IBD,ulcerative colitis,UC,mesenchymal stem cells,MSCs"为检索词,检索时间为2001年1月至2020年4月,检索得到文献115篇,选择42篇文献进行归纳。文献类型包括实验分析、病例分析及综述。结果与结论:干细胞具有归巢、分化、免疫调节作用,为其治疗溃疡性结肠炎提供了可能。相关的动物实验和临床研究表明,间充质干细胞治疗溃疡性结肠炎安全有效,但是有关移植细胞的剂量及途径尚存在争议。随着对间充质干细胞治疗溃疡性结肠炎的进一步研究和临床试验的开展,间充质干细胞移植有望成为一种治疗溃疡性结肠炎的可期方案。 展开更多
关键词 干细胞 间充质干细胞 移植 治疗 溃疡性结肠炎 免疫调节 综述
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Chiari malformations in children:An overview 认领
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作者 Peter Spazzapan Roman Bosnjak +1 位作者 Borut Prestor Tomaz Velnar 《世界临床病例杂志》 SCIE 2021年第4期764-773,共10页
Chiari malformations encompass various radiological and clinical entities,sharing the herniation of the rhombencephalic structures through the foramen magnum as a common characteristic.They can be symptomatic or asymp... Chiari malformations encompass various radiological and clinical entities,sharing the herniation of the rhombencephalic structures through the foramen magnum as a common characteristic.They can be symptomatic or asymptomatic.The therapeutic strategies for these malformations differ on the basis of the diverse pathophysiologic processes that cause them.As Chiari malformations are caused by various pathophysiologic processes,they must be recognized promptly to select the best treatment for each single case. 展开更多
关键词 Chiari malformation HYDROCEPHALUS Intracranial pressure Craniocervical junction Foramen magnum TREATMENT
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Non-invasive electrical stimulation as a potential treatment for retinal degenerative diseases 认领
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作者 Karen Chang Sam Enayati +2 位作者 Kin-Sang Cho Tor P.Utheim Dong Feng Chen 《中国神经再生研究:英文版》 SCIE CAS 2021年第8期1558-1559,共2页
More than 38.5 million people are estimated to be affected by blindness worldwide in 2020(Flaxman et al., 2017). Among the diseases that cause visual impairment, refractive errors are typically corrected with glasses ... More than 38.5 million people are estimated to be affected by blindness worldwide in 2020(Flaxman et al., 2017). Among the diseases that cause visual impairment, refractive errors are typically corrected with glasses and cataract with surgery. The leading causes of irreversible blindness nowadays are usually degenerative diseases related to the retina and its extending optic nerves. 展开更多
关键词 GLASSES TREATMENT typically
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36例犬吉氏巴贝斯虫病的诊断与治疗 认领
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作者 冯鹏 王新 +5 位作者 张小波 魏彤 田庆雷 张津 张靖飞 王新来 《动物医学进展》 北大核心 2021年第2期138-141,共4页
西安市某宠物医院从2018年-2019年共接诊了36例犬吉氏巴贝斯虫病,对这36例病例的临床症状、流行病学、实验室诊断和治疗进行了调查和研究。结果表明,犬感染吉氏巴贝斯虫后主要症状为虚弱、发热、尿黄等。该病的高发期在9月和10月,占总... 西安市某宠物医院从2018年-2019年共接诊了36例犬吉氏巴贝斯虫病,对这36例病例的临床症状、流行病学、实验室诊断和治疗进行了调查和研究。结果表明,犬感染吉氏巴贝斯虫后主要症状为虚弱、发热、尿黄等。该病的高发期在9月和10月,占总发病的50%。发病年龄主要是1岁至5岁犬,占69.4%。实验室检查显示感染犬的红细胞和血小板显著下降,白细胞变化不定,尿液分析和生化检查也没有明确指示意义。当镜检看到明显的虫体时,即可确诊。治疗选用三氮脒皮下或者肌肉注射10 mg/kg体重,第1、3、7天分别注射。同时采取对症治疗和支持疗法,贫血严重的需要输血治疗。36例病例有32例康复,治愈率为89.9%,其中8例出现了复发,复发率达22.1%。 展开更多
关键词 吉氏巴贝斯虫 诊断 治疗 犬
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The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression 认领
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作者 Andrea Kwakowsky Henry J.Waldvogel Richard LM Faull 《中国神经再生研究:英文版》 SCIE CAS 2021年第7期1399-1401,共3页
The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative disorder.The underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay ... The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative disorder.The underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay progression of the disease.Currently,most investigation is directed towards the amyloid-beta(Aβ)and tau pathologies,中文标题:The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression中文关词:Glu;AMPAR;APP;The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression;中文摘要:The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative disorder.The underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay progression of the disease. 展开更多
关键词 ALZHEIMER TAU Aβ treatment
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