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Animal models used to study direct peripheral nerve repair:a systematic review 预览
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作者 Francisco Javier Vela Guadalupe Martínez-Chacón +3 位作者 Alberto Ballestín JoséLuis Campos Francisco Miguel Sánchez-Margallo Elena Abellán 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期491-502,共12页
Objective:Peripheral nerve repair is required after traumatic injury.This common condition represents a major public health problem worldwide.Recovery after nerve repair depends on several factors,including the severi... Objective:Peripheral nerve repair is required after traumatic injury.This common condition represents a major public health problem worldwide.Recovery after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical skills.Despite the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being studied.Pre-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRISMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair studies.Data sources:Original articles,published in English from 2000 to 2018,were collected using the Web of Science,Scopus,and PubMed databases.Data selection:Only preclinical trials on direct nerve repair were included in this review.The articles were evaluated by the first two authors,in accordance with predefined data fields.Outcome measures:The primary outcomes included functional motor abilities,daily activity and regeneration rate.Secondary outcomes included coaptation technique and animal model.Results:This review yielded 267 articles,of which,after completion of the screening,49 studies were analyzed.There were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical models.The nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the rat.Other animal models are also used but the cost-benefit of the rat model provides several strengths over the others.Suture techniques are currently the first option for 展开更多
关键词 NERVE MICROSURGERY peripheral NERVE regeneration REPAIR reconstruction DIRECT NERVE REPAIR animal model coaptation PRISMA systematic review
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Peripheral nerve injury induced changes in the spinal cord and strategies to counteract/enhance the changes to promote nerve regeneration 预览
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作者 Yan Liu Huan Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期189-198,共10页
Peripheral nerve injury leads to morphological, molecular and gene expression changes in the spinal cord and dorsal root ganglia, some of which have positive impact on the survival of neurons and nerve regeneration, w... Peripheral nerve injury leads to morphological, molecular and gene expression changes in the spinal cord and dorsal root ganglia, some of which have positive impact on the survival of neurons and nerve regeneration, while the effect of others is the opposite. It is crucial to take prompt measures to capitalize on the positive effects of these reactions and counteract the negative impact after peripheral nerve injury at the level of spinal cord, especially for peripheral nerve injuries that are severe, located close to the cell body, involve long distance for axons to regrow and happen in immature individuals. Early nerve repair, exogenous supply of neurotrophic factors and Schwann cells can sustain the regeneration inductive environment and enhance the positive changes in neurons. Administration of neurotrophic factors, acetyl-L-carnitine, N-acetyl-cysteine, and N-methyl-D-aspartate receptor antagonist MK-801 can help counteract axotomy-induced neuronal loss and promote regeneration, which are all time-dependent. Sustaining and reactivation of Schwann cells after denervation provides another effective strategy. FK506 can be used to accelerate axonal regeneration of neurons, especially after chronic axotomy. Exploring the axotomy-induced changes after peripheral nerve injury and applying protective and promotional measures in the spinal cord which help to retain a positive functional status for neuron cell bodies will inevitably benefit regeneration of the peripheral nerve and improve functional outcomes. 展开更多
关键词 AXOTOMY DORSAL root GANGLION neural regeneration NEUROTROPHIC factors outcomes peripheral nerve injury repair spinal CORD
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间充质干细胞线粒体转移治疗修复组织损伤的作用 预览
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作者 王张玲 余丽梅 赵春华 《中国组织工程研究》 CAS 北大核心 2020年第7期1123-1129,共7页
背景:间充质干细胞因其众多优点被应用于多种疾病治疗,线粒体转移是间充质干细胞疗法的重要机制之一。目的:综述间充质干细胞通过线粒体转移在各类组织损伤中发挥的作用。方法:由第一作者以“stem cells,mitochondrial transfer,cell co... 背景:间充质干细胞因其众多优点被应用于多种疾病治疗,线粒体转移是间充质干细胞疗法的重要机制之一。目的:综述间充质干细胞通过线粒体转移在各类组织损伤中发挥的作用。方法:由第一作者以“stem cells,mitochondrial transfer,cell communication,rescue and repair,tissue injury”为英文关键词,以“干细胞,线粒体转移,细胞通讯,修复,组织损伤”为中文关键词,检索2008至2019年期间收录在PubMed、中国知网、万方数据库中的文献,纳入间充质干细胞的线粒体转移作用和机制及治疗组织损伤相关的文献,排除重复与相关性弱的文献,对64篇文献进行总结分析。结果与结论:间充质干细胞被应用于如脑卒中、心肌梗死、急性肾功能衰竭等多种疾病治疗,线粒体转移作为干细胞治疗的一种新机制被人们广泛关注,已被认为是组织损伤的潜在疗法;线粒体转移已发现由隧道管形成、间隙连接、微囊泡、细胞融合和分离等不同模式介导,但线粒体转移在组织损伤中的具体机制还未完全阐明,其在组织损伤修复中的具体作用也有待进一步了解。 展开更多
关键词 线粒体转移 间充质干细胞 组织损伤 干细胞 损伤修复
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Skeletal muscle-derived cells repair peripheral nerve defects in mice 预览
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作者 Zi-Xiang Chen Hai-Bin Lu +3 位作者 Xiao-Lei Jin Wei-Feng Feng Xiao-Nan Yang Zuo-Liang Qi 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期152-161,共10页
Skeletal muscle-derived cells have strong secretory function,while skeletal muscle-derived stem cells,which are included in muscle-derived cells,can differentiate into Schwann cell-like cells and other cell types.Howe... Skeletal muscle-derived cells have strong secretory function,while skeletal muscle-derived stem cells,which are included in muscle-derived cells,can differentiate into Schwann cell-like cells and other cell types.However,the effect of muscle-derived cells on peripheral nerve defects has not been reported.In this study,5-mm-long nerve defects were created in the right sciatic nerves of mice to construct a peripheral nerve defect model.Adult female C57BL/6 mice were randomly divided into four groups.For the muscle-derived cell group,muscle-derived cells were injected into the catheter after the cut nerve ends were bridged with a polyurethane catheter.For external oblique muscle-fabricated nerve conduit and polyurethane groups,an external oblique muscle-fabricated nerve conduit or polyurethane catheter was used to bridge the cut nerve ends,respectively.For the sham group,the sciatic nerves on the right side were separated but not excised.At 8 and 12 weeks post-surgery,distributions of axons and myelin sheaths were observed,and the nerve diameter was calculated using immunofluorescence staining.The number,diameter,and thickness of myelinated nerve fibers were detected by toluidine blue staining and transmission electron microscopy.Muscle fiber area ratios were calculated by Masson’s trichrome staining of gastrocnemius muscle sections.Sciatic functional index was recorded using walking footprint analysis at 4,8,and 12 weeks after operation.The results showed that,at 8 and 12 weeks after surgery,myelin sheaths and axons of regenerating nerves were evenly distributed in the muscle-derived cell group.The number,diameter,and myelin sheath thickness of myelinated nerve fibers,as well as gastrocnemius muscle wet weight and muscle area ratio,were significantly higher in the muscle-derived cell group compared with the polyurethane group.At 4,8,and 12 weeks post-surgery,sciatic functional index was notably increased in the muscle-derived cell group compared with the polyurethane group.These criteria of the muscle-derived cel 展开更多
关键词 MUSCLE NERVE conduit myokine NERVE REGENERATION NERVE REPAIR peripheral NERVE REGENERATION polyurethane catheter seed CELLS SKELETAL MUSCLE SKELETAL muscle-derived CELLS tissue-engineered NERVE
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Protective effect of rhodioloside and bone marrow mesenchymal stem cells infected with HIF-1-expressing adenovirus on acute spinal cord injury 预览
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作者 Xiao-Qin Ha Bo Yang +3 位作者 Huai-Jing Hou Xiao-Ling Cai Wan-Yuan Xiong Xu-Pan Wei 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期690-696,共7页
Rhodioloside has been shown to protect cells from hypoxia injury,and bone marrow mesenchymal stem cells have a good effect on tissue repair.To study the effects of rhodioloside and bone marrow mesenchymal stem cells o... Rhodioloside has been shown to protect cells from hypoxia injury,and bone marrow mesenchymal stem cells have a good effect on tissue repair.To study the effects of rhodioloside and bone marrow mesenchymal stem cells on spinal cord injury,a rat model of spinal cord injury was established using the Infinite Horizons method.After establishing the model,the rats were randomly divided into five groups.Rats in the control group were intragastrically injected with phosphate buffered saline(PBS)(5μL).PBS was injected at 6 equidistant points around 5 mm from the injury site and at a depth of 5 mm.Rats in the rhodioloside group were intragastrically injected with rhodioloside(5 g/kg)and intramuscularly injected with PBS.Rats in the mesenchymal stem cell(MSC)group were intramuscularly injected with PBS and intramuscularly with MSCs(8×10^6/mL in a 50-μL cell suspension).Rats in the Ad-HIF-MSC group were intragastrically injected with PBS and intramuscularly injected with HIF-1 adenovirus-infected MSCs.Rats in the rhodioloside+Ad-HIF-MSC group were intramuscularly injected with MSCs infected with the HIF-1 adenovirus and intragastrically injected with rhodioloside.One week after treatment,exercise recovery was evaluated with a modified combined behavioral score scale.Hematoxylin-eosin staining and Pischingert’s methylene blue staining were used to detect any histological or pathological changes in spinal cord tissue.Levels of adenovirus IX and Sry mRNA were detected by real-time quantitative polymerase chain reaction and used to determine the number of adenovirus and mesenchymal stem cells that were transfected into the spinal cord.Immunohistochemical staining was applied to detect HIF-1 protein levels in the spinal cord.The results showed that:(1)compared with the other groups,the rhodioloside+Ad-HIF-MSC group exhibited the highest combined behavioral score(P<0.05),the most recovered tissue,and the greatest number of neurons,as indicated by Pischingert’s methylene blue staining.(2)Compared with the PBS group,HIF-1 pro 展开更多
关键词 acute spinal cord injury ADENOVIRUS ADENOVIRUS gene IX bone MARROW mesenchymal stem cells combined behavioral score scale HIF-1α NERVE regeneration NERVE repair RHODIOLA rosea SRY
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The first two cases of transcatheter mitral valve repair with ARTO system in Asia 预览
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作者 Kai-da Ren Zhao-xia Pu +10 位作者 Lei Yu Feng Gao Li-han Wang Stella Ng Ju-bo Jiang Hua-jun Li Yong Xu Wei He Min Yan Xian-bao Liu Jian-an Wang 《世界急诊医学杂志(英文)》 CAS CSCD 2020年第1期33-36,共4页
BACKGROUND:MAVERIC(Mitral Valve Repair Clinical Trial)validates the safety and effi cacy of the ARTO system.We here report the fi rst two successful cases of utilizing the ARTO system in patients with symptomatic hear... BACKGROUND:MAVERIC(Mitral Valve Repair Clinical Trial)validates the safety and effi cacy of the ARTO system.We here report the fi rst two successful cases of utilizing the ARTO system in patients with symptomatic heart failure(HF)with functional mitral regurgitation(FMR)in Asia.METHODS:Two patients,aged 70 and 63,had severe HF with FMR.Transesophageal echocardiography confirmed that the left ventricular ejection fractions were less than 50%with severe mitral regurgitation(MR)in both patients.Optimizing drug treatment could not mitigate their symptoms.Therefore,we used the ARTO system to repair the mitral valve for these patients on March 5 and 6,2019,respectively.RESULTS:Mitral valve repairs using the ARTO system were successfully performed under general anaesthesia for these two patients.MR was decreased immediately after the procedures in both patients.The 30-day and 3-month transthoracic echocardiography(TTE)revealed a moderate to severe MR in both patients,and the New York Heart Association(NYHA)scales were also partially improved.CONCLUSION:The first two cases in Asia indicate that the ARTO system is feasible for patients with heart failure with FMR,and the patient selection appears to be crucial. 展开更多
关键词 Mitral regurgitation Mitral valve repair ARTO system
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原位组织工程技术修复骨与软骨损伤:应用及存在的问题 预览
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作者 张骏 尤奇 +2 位作者 邹刚 葛振 刘毅 《中国组织工程研究》 CAS 北大核心 2019年第20期3255-3260,共6页
背景:原位组织工程技术较传统的组织工程技术有明显的优势,在促进组织再生和骨、软骨修复方面具有较好的效果。目的:综述原位组织工程技术在骨与软骨修复中的应用及存在的问题。方法:应用计算机检索CNKI数据库、PubMed数据库及Elsevier... 背景:原位组织工程技术较传统的组织工程技术有明显的优势,在促进组织再生和骨、软骨修复方面具有较好的效果。目的:综述原位组织工程技术在骨与软骨修复中的应用及存在的问题。方法:应用计算机检索CNKI数据库、PubMed数据库及Elsevier数据库中发表的相关文献,中文检索词为'原位组织工程技术,骨,软骨,骨缺损,软骨修复,组织工程',英文检索词为'in situ tissue engineering,bone,cartilage,bonedefects,cartilagerepair,tissueengineering',选择2000年1月至2018年11月收录的原位组织工程技术在骨和软骨损伤修复中应用的相关文章,包括综述、基础及临床研究。结果与结论:原位组织工程技术是在传统组织工程技术基础上发展起来的一种用于再生和修复的技术,应用于骨损伤修复取得了良好的成绩,其不依赖外源种子细胞,通过各种新型支架材料并利用其自身特有的结构和理化性质,募集受损部位周边的干细胞迁徙到损伤部位,完成骨损伤的原位修复。原位组织工程技术为软骨损伤修复提供了新的思路和方向,在软骨损伤修复中具有全新应用价值,其主要是利用植入的支架材料来诱导局部微环境,诱导周边细胞迁移到病损部位而发挥修复作用。 展开更多
关键词 原位组织工程技术 软骨 修复 组织工程 支架材料 细胞因子 损伤的原位修复
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上海徐家汇天主教堂外墙面修缮 预览
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作者 朱嫣 《住宅科技》 2019年第7期21-26,共6页
徐家汇天主教堂已有百年的历史,不可避免地留下了岁月的痕迹。修复的标准是尽可能保持原貌,修旧如旧,并参照历史文献对损坏的部分进行修复。修复的第一步是先根据外墙的损伤类型进行清理,然后在此基础上根据外墙的不同材料和损伤程度进... 徐家汇天主教堂已有百年的历史,不可避免地留下了岁月的痕迹。修复的标准是尽可能保持原貌,修旧如旧,并参照历史文献对损坏的部分进行修复。修复的第一步是先根据外墙的损伤类型进行清理,然后在此基础上根据外墙的不同材料和损伤程度进行精细修复。 展开更多
关键词 徐家汇天主教堂 外墙面清理 修缮 精细修复
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A manual inspection of Defects4J bugs and its implications for automatic program repair
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作者 Jiajun JIANG Yingfei XIONG Xin XIA 《中国科学:信息科学(英文版)》 SCIE EI CSCD 2019年第10期31-46,共16页
Automatic program repair techniques, which target to generate correct patches for real-world defects automatically, have gained a lot of attention in the last decade. Many different techniques and tools have been prop... Automatic program repair techniques, which target to generate correct patches for real-world defects automatically, have gained a lot of attention in the last decade. Many different techniques and tools have been proposed and developed. However, even the most sophisticated automatic program repair techniques can only repair a small portion of defects while producing a large number of incorrect patches.A possible reason for the low performance is the test suites of real-world programs are usually too weak to guarantee the behavior of a program. To understand to what extent defects can be fixed with exiting test suites, we manually analyzed 50 real-world defects from Defects4J, where a large portion(i.e., 82%) of them were correctly fixed. This result suggests that there is much room for the current automatic program repair techniques to improve. Furthermore, we summarized seven fault localization and seven patch generation strategies that are useful in localizing and fixing these defects, and compared those strategies with current techniques. The results indicate potential directions to improve automatic program repair in the future. 展开更多
关键词 AUTOMATIC DEFECT REPAIR FAULT LOCALIZATION MANUAL REPAIR software maintenance case study
PIK-75 promotes homology-directed DNA repair
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作者 Guoling Li Xianwei Zhang +4 位作者 Hao Ou Haoqiang Wang Dewu Liu Huaqiang Yang Zhenfang Wu 《遗传学报:英文版》 SCIE CAS CSCD 2019年第3期141-144,共4页
Homo!ogy-directed repair(HDR)is one of two major DNA repair pathways to mend the double-strand breaks(DSBs)formed in the genome(Liang et al.,1998;Pardo et al.,2009).Although less efficient compared with another DNA re... Homo!ogy-directed repair(HDR)is one of two major DNA repair pathways to mend the double-strand breaks(DSBs)formed in the genome(Liang et al.,1998;Pardo et al.,2009).Although less efficient compared with another DNA repair pathway,nonhomologous end joining(NHEJ),HDR is a type of precise repair to restore DNA damage and sustain genomic stability(Pardo et al.,2009;Ceccaldi et al.,2016).By contrast,NHEJ usually introduces mutations into the repaired site,thus probably harming the genomic integrity(Lieber et al.,2003).The error-free property enables HDR to be harnessed to correct a faulty mutation for therapeutic purpose in cells or in the body(Wu et al.,2013).In add让ion,HDR possesses great potential in the generation of genome-edited animals with precise genetic modifications,such as point mutation,DNA replacement,and DNA insertion in a specific genomic site(Wang et al.,2013).However,the low repair frequency mediated by HDR significantly limits让s application for efficient gene correction or establishment of various genetically modified animal models.Currently,multiple site-specific endonucleases have emerged as highly efficient tools to create targeted DSBs and markedly promote subsequent DNA repair either via HDR or NHEJ(Gaj et al.,2013).Nonetheless,the HDR-mediated modifications following the cleavage of engineering nucleases are still inefficient,usually with an efficiency less than 20%in cultured mammalian cells and embryos(Mali et al..2013;Wang et al.,2013;Yang et al.,2013). 展开更多
关键词 ogy-directed REPAIR MAJOR DNA REPAIR MAMMALIAN cells
核电厂海水管道法兰面缝隙腐蚀原因分析及解决措施 预览
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作者 吴昉赟 周澄 +1 位作者 董海涛 蒋益丰 《全面腐蚀控制》 2019年第2期89-91,共3页
某核电厂在首次大修腐蚀检查中发现海水管道多个法兰面发生了腐蚀问题。本文通过分析海水管道法兰面的结构特点,得出是由于管道法兰面垫片与法兰密封面尺寸不一致,以及该系统管道涂层与基材存在分层问题而发生了缝隙腐蚀,另外针对法兰... 某核电厂在首次大修腐蚀检查中发现海水管道多个法兰面发生了腐蚀问题。本文通过分析海水管道法兰面的结构特点,得出是由于管道法兰面垫片与法兰密封面尺寸不一致,以及该系统管道涂层与基材存在分层问题而发生了缝隙腐蚀,另外针对法兰面锈蚀问题提出了有效可行的维修措施。 展开更多
关键词 海水管道 法兰 缝隙腐蚀 修复
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检修热交换器时液压试验压力的确定 预览
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作者 李春光 陈罡 张光 《石油化工设备技术》 CAS 2019年第6期53-55,I0005共4页
液压试验是工程上压力容器制造或修理完工后通常采用的最终质量检验方法。试验压力在压力容器规程、标准中虽有规定,但是其对在用压力容器修理时的液压试验压力取值却没有最初制造时规定得那么明确,因此容易出现偏差而影响液压试验的准... 液压试验是工程上压力容器制造或修理完工后通常采用的最终质量检验方法。试验压力在压力容器规程、标准中虽有规定,但是其对在用压力容器修理时的液压试验压力取值却没有最初制造时规定得那么明确,因此容易出现偏差而影响液压试验的准确性与安全性。文章通过对1例浮头式热交换器修理时的液压试验压力取值进行讨论,得出在用压力容器修理时液压试验压力的确定原则,即首次定期检验前按竣工图确定,定期检验后的检验周期内则按《定期检验报告》确定。 展开更多
关键词 热交换器 修理 液压试验 试验压力
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混凝土路面板预制拼接快速修复技术研究 预览
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作者 张敏 王海洋 陆金驰 《结构工程师》 北大核心 2019年第5期212-216,共5页
针对目前混凝土路面板预制拼装维修技术中混凝土板调平和板底脱空问题,提出一种简单快捷的调平技术和施工方法。通过在混凝土板中设置路面施工辅助构件,保证路面的平整度,并且开发方便有效的注浆工艺,对混凝土板的底部脱空区域进行灌浆... 针对目前混凝土路面板预制拼装维修技术中混凝土板调平和板底脱空问题,提出一种简单快捷的调平技术和施工方法。通过在混凝土板中设置路面施工辅助构件,保证路面的平整度,并且开发方便有效的注浆工艺,对混凝土板的底部脱空区域进行灌浆,保证混凝土板底的底部和路面基层的牢固结合,保证路面的耐久性和路面质量。 展开更多
关键词 混凝土板 维修 调平技术 注浆工艺 耐久性
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基于形态法评估的煤矿污染土壤修复方法研究 预览
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作者 钟凯 《环境科学与管理》 CAS 2019年第7期106-110,共5页
为了更好地掌握煤矿污染土壤现状,需要评估污染土壤修复方法的优劣,提出了基于形态法评估的矿区污染土壤修复方法,该方法在研究区域布设采样点采集煤矿污染土壤样品,并对采集获得的土壤样品进行进一步处理及测定,并采用形态法对处理、... 为了更好地掌握煤矿污染土壤现状,需要评估污染土壤修复方法的优劣,提出了基于形态法评估的矿区污染土壤修复方法,该方法在研究区域布设采样点采集煤矿污染土壤样品,并对采集获得的土壤样品进行进一步处理及测定,并采用形态法对处理、测定后的矿区污染土壤样品中的污染物进行形态分级,实现了煤矿污染土壤修复评估;在此基础上,在模拟室温条件下,以煤矿区铅、锌重金属污染土壤为例,分析了不同P处理对煤矿污染土壤pH和水溶性P的影响、不同P处理对煤矿污染土壤水溶性Pb、Zn的影响,以及不同P处理对煤矿污染土壤中交换态Pb、Zn含量的影响情况。 展开更多
关键词 形态法 评估 煤矿污染土壤 修复
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Mucosal healing progression after acute colitis in mice 预览
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作者 Sandra Vidal-Lletjós Mireille Andriamihaja +7 位作者 Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Fran?ois Blachier Anna?g Lan 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第27期3572-3589,共18页
BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as ... BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of cert 展开更多
关键词 COLON LUMINAL environment DEXTRAN sodium sulfate-induced COLITIS DYSBIOSIS Epithelial repair ACUTE COLITIS
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卫生陶瓷干坯裂纹修补的新材料研制 预览
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作者 徐文龙 陈拥强 +1 位作者 唐小勇 范文杰 《陶瓷》 CAS 2019年第10期43-47,共5页
目前大部分卫生陶瓷企业调制修补材料都是采用耐火棉,耐火棉在较高温度烧成后吸水率偏大容易导致后期风裂及色差的问题。笔者结合生产实际案例,搜集了与相关专业的文献资料,研究通过引入玻纤布、镨黄、瓷粉、氧化铝等原料组成的新材料... 目前大部分卫生陶瓷企业调制修补材料都是采用耐火棉,耐火棉在较高温度烧成后吸水率偏大容易导致后期风裂及色差的问题。笔者结合生产实际案例,搜集了与相关专业的文献资料,研究通过引入玻纤布、镨黄、瓷粉、氧化铝等原料组成的新材料来调整修补材料的色差及抗龟裂性能,减少由修补材料引起的缺陷,并探究了修补干坯裂纹工艺,寻找最佳修补干坯裂纹的工艺以及最佳修补材料配方。 展开更多
关键词 卫生陶瓷 玻纤 裂纹 修补 配方
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高压甲铵泵缸体冲刷腐蚀原因分析及修复 预览
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作者 薛继庆 《大氮肥》 CAS 2019年第5期321-322,共2页
针对尿素装置立式五柱塞高压甲铵泵缸体冲刷腐蚀泄漏原因进行分析,在不更换新缸体的情况下,对冲刷腐蚀的缸体采用焊接和镗孔方式进行修复,相比于整体换缸修复,性价比更高。
关键词 高压甲铵泵 腐蚀 缸体 修复
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鼻前庭病变术后鼻前庭功能重建术的临床应用 预览
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作者 刘杰 邹璨 +4 位作者 柯霞 沈暘 黄江菊 胡国华 杨玉成 《中国耳鼻咽喉颅底外科杂志》 CAS 2019年第2期118-120,共3页
目的探讨鼻前庭功能性重建术术式的选择和修复方法。方法回顾分析2012年10月~2018年10月完成的鼻前庭病变行鼻前庭功能性重建术患者27例,其中行局部带蒂皮瓣修复19例、游离皮瓣修复7例、生物膜修复1例,术后随访2~24个月,评估其疗效及并... 目的探讨鼻前庭功能性重建术术式的选择和修复方法。方法回顾分析2012年10月~2018年10月完成的鼻前庭病变行鼻前庭功能性重建术患者27例,其中行局部带蒂皮瓣修复19例、游离皮瓣修复7例、生物膜修复1例,术后随访2~24个月,评估其疗效及并发症。结果 27例患者均Ⅰ期完成手术修复和功能重建,术后皮瓣全部成活,无明显通气功能障碍,患者对疗效评估非常满意为74.1%(20/27),满意为25.9%(7/27)。结论鼻前庭病变应根据病变性质、部位、大小、深度等选择合适的方法进行修复和功能重建;局部带蒂皮瓣可作为鼻前庭组织缺损的首选修复方法,值得推广应用。 展开更多
关键词 鼻前庭 功能性重建 皮瓣 修复
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矿物材料修复重金属污染的研究进展 预览
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作者 张宝强 《中国资源综合利用》 2019年第7期100-102,共3页
重金属污染已经成为严重的环境问题,威胁着人类的健康,逐渐引起了人们的高度关注。环境矿物材料作为一种具有修复环境功能的矿物材料,其已被广泛应用到重金属污染的修复中。矿物材料修复重金属污染具有高效、经济、无二次污染等特点,可... 重金属污染已经成为严重的环境问题,威胁着人类的健康,逐渐引起了人们的高度关注。环境矿物材料作为一种具有修复环境功能的矿物材料,其已被广泛应用到重金属污染的修复中。矿物材料修复重金属污染具有高效、经济、无二次污染等特点,可有效替代物理、化学、生物等传统修复方法。本文综述了土壤重金属污染的概况,说明了重金属污染的危害,论述了重金属的分布和来源特征,分析了矿物材料修复重金属的现状和特性。 展开更多
关键词 环境矿物材料 重金属 修复
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数控机床导轨修复方法研究 预览
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作者 林海华 《科技视界》 2019年第12期155-156,共2页
目前我国大型数控机床开始表现出高精度、重载与自动化的特征,传统数控机床导轨修复技术存在一定局限性,为此,提出数控机床导轨修复方法研究。经过排查故障监测模块、检查机床导轨磨损部位、检测机床导轨润滑度与切削用量三个步骤,实现... 目前我国大型数控机床开始表现出高精度、重载与自动化的特征,传统数控机床导轨修复技术存在一定局限性,为此,提出数控机床导轨修复方法研究。经过排查故障监测模块、检查机床导轨磨损部位、检测机床导轨润滑度与切削用量三个步骤,实现对数控机床导轨的修复。将本文修复方法与传统方法相比,随着使用时间的延长,其修复效率一直呈现上涨趋势,且明显高于传统修复方法。 展开更多
关键词 数控机床 导轨 修复 方法
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