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Action of trichostatin A on Alzheimer’s disease-like pathological changes in SH-SY5Y neuroblastoma cells 预览
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作者 Li-Hua Li Wen-Na Peng +2 位作者 Yu Deng1 Jing-Jing Li Xiang-Rong Tian 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期293-301,共9页
The histone deacetylase inhibitor, trichostatin A, is used to treat Alzheimer’s disease and can improve learning and memory but its underlying mechanism of action is unknown. To determine whether the therapeutic effe... The histone deacetylase inhibitor, trichostatin A, is used to treat Alzheimer’s disease and can improve learning and memory but its underlying mechanism of action is unknown. To determine whether the therapeutic effect of trichostatin A on Alzheimer’s disease is associated with the nuclear factor erythroid 2-related factor 2(Nrf2) and Kelch-like epichlorohydrin-related protein-1(Keap1) signaling pathway, amyloid β-peptide 25–35(Aβ25–35) was used to induce Alzheimer’s disease-like pathological changes in SH-SY5 Y neuroblastoma cells. Cells were then treated with trichostatin A. The effects of trichostatin A on the expression of Keap1 and Nrf2 were detected by real-time quantitative polymerase chain reaction, western blot assays and immunofluorescence. Total antioxidant capacity and autophagy activity were evaluated by total antioxidant capacity assay kit and light chain 3-I/II levels, respectively. We found that trichostatin A increased cell viability and Nrf2 expression, and decreased Keap1 expression in SH-SY5 Y cells. Furthermore, trichostatin A increased the expression of Nrf2-related target genes, such as superoxide dismutase, NAD(P)H quinone dehydrogenase 1 and glutathione S-transferase, thereby increasing the total antioxidant capacity of SH-SY5 Y cells and inhibiting amyloid β-peptide-induced autophagy. Knockdown of Keap1 in SH-SY5 Y cells further increased trichostatin A-induced Nrf2 expression. These results indicate that the therapeutic effect of trichostatin A on Alzheimer’s disease is associated with the Keap1-Nrf2 pathway. The mechanism for this action may be that trichostatin A increases cell viability and the antioxidant capacity of SH-SY5 Y cells by alleviating Keap1-mediated inhibition Nrf2 signaling, thereby alleviating amyloid β-peptide-induced cell damage. 展开更多
关键词 Alzheimer's disease amyloid-β peptide autophagy KEAP1 signal neurocytotoxicity oxidative stress damage SH-SY5Y cells total antioxidant capacity transcription factor Nrf2 TSA
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Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases 预览
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作者 Rubaiya Tabassum Na Young Jeong Junyang Jung 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期653-662,共10页
Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related disease... Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related diseases is oxidative stress.In recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully explored.The enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S.Previously,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related neurodegeneration.Due to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and Bcl-2.This review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome. 展开更多
关键词 3-mercaptopyruvate SULFURTRANSFERASE aging antioxidant cystathionineβ-synthase cystathionineγ-lyase GLUTATHIONE hydrogen sulfide NEURODEGENERATIVE disease oxidative stress reactive oxygen species
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Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases 预览
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作者 Rubaiya Tabassum Na Young Jeong Junyang Jung 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期232-241,共10页
Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where r... Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main source of oxidative stress. When the normal redox balance is disturbed, deoxyribonucleic acid, lipid, and protein molecules are oxidized under pathological conditions, like diabetes mellitus that leads to diabetic peripheral neuropathy. In diabetes mellitus-induced diabetic peripheral neuropathy, due to hyperglycemia, pancreatic beta cell(β cell) shows resistance to insulin secretion. As a consequence, glucose metabolism is disturbed in neuronal cells which are distracted from providing proper cell signaling pathway. Not only diabetic peripheral neuropathy but also other central damages occur in brain neuropathy. Neurological studies regarding type 1 diabetes mellitus patients with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis have shown changes in the central nervous system because high blood glucose levels(HbA1 c) appeared with poor cognitive function. Oxidative stress plays a role in inhibiting insulin signaling that is necessary for brain function. Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine β synthase, cystathionine γ lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide. This review is to explore the pathogenesis of diabetes mellitus-induced diabetic peripheral neuropathy and other neurological comorbid disorders under the oxidative stress condition and the anti-oxidative effects of hydrogen sulfide. 展开更多
关键词 Alzheimer's DISEASE amyotrophic lateral SCLEROSIS antioxidant diabetic peripheral NEUROPATHY DNA oxidation hydrogen SULFIDE mitochondrial dysfunction oxidative stress Parkinson's DISEASE reactive oxygen species
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A Comparison of the Antioxidative and Anti-Diabetic Potential of Thermally Treated Garlic, Turmeric, and Ginger 预览
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作者 Fredreana Hester Martha Verghese +2 位作者 Rajitha Sunkara Shantrell Willis Lloyd T. Walker 《食品与营养科学(英文)》 2019年第2期207-219,共13页
Spices have been used for centuries for food preservation, flavors, and medicinal properties. Research suggests that garlic, turmeric, and ginger contain potent antioxidants that may prevent and/or delay chronic disea... Spices have been used for centuries for food preservation, flavors, and medicinal properties. Research suggests that garlic, turmeric, and ginger contain potent antioxidants that may prevent and/or delay chronic diseases such as cancer, diabetes, and heart disease. Heat treatment of spices may potentially increase antioxidative activity by modifying the inherent chemical structure of potent antioxidative compounds within spices. The purpose of this study was to determine the impact of thermal treatment of garlic, ginger, and turmeric on total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferric reducing antioxidant potential (FRAP), trolox activity (TEAC), lipase, a-amylase, and a-glucosidase inhibition. Conventional stovetop heating of selected spices was performed followed by methanolic and aqueous extractions (1 - 5 minutes;70°C - 130°C). Overall methanolic extracts had higher phytochemical, antioxidative, and anti-diabetic potential. However, aqueous garlic extracts exhibited higher phytochemical and antioxidative potential over methanolic garlic extracts. The highest TPC for aqueous garlic extracts was observed at 1 minute (14.11 mg GAE/g) while methanolic garlic extracts at 1 minute were significantly lower (1.72 mg GAE/g). Methanolic turmeric extracts had highest TPC at 5 minutes (28.55 mg GAE/g). Time and temperature influenced antioxidant activity in the spices. Turmeric and ginger (methanolic extracts) resulted in higher percent inhibition of DPPH radical with an increase in time (5 minute) turmeric (86.9%) and ginger (79.09%) at 7.9 mg/mL concentration. The results of this study revealed both solvent and time for thermal treatment of spices influenced antioxidative potential as determined using DPPH and FRAP assays. Therefore, the use of thermal application on spices presents promise in potentiating the antioxidant content and thereby their potential health promoting properties. Spices are utilized in the U.S. food industry and increa 展开更多
关键词 Turmeric GARLIC GINGER THERMAL Treatment ANTIOXIDANT
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Antioxidant Activity and Hepatoprotective Potential of <i>Piper chaba</i>Roots against Paracetamol-Induced Liver Injury 预览
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作者 Samina Yesmin Ronok Zahan +4 位作者 Md. Monjad Hossain A. B. M. Atiqur Rahman Alam Khan Mir Imam Ibne Wahed Tarannum Naz 《药理与制药(英文)》 2019年第11期484-497,共14页
Paracetamol induces oxidative damage of liver and hepatotoxicity continues to be among the main threats of public health. The present study evaluated the antioxidant and hepatoprotective activities of P. chaba roots. ... Paracetamol induces oxidative damage of liver and hepatotoxicity continues to be among the main threats of public health. The present study evaluated the antioxidant and hepatoprotective activities of P. chaba roots. Hepatoprotective effects were demonstrated by significant alteration of serum biomarker enzymes and antioxidant enzymes. Co-administration of P. chaba extract to paracetamol-induced rats resulted in a partial recovery in the serum biochemical parameters (SGOT, SGPT, ALP and Bilirubin). However, ethanolic extract of Piper chaba at lower dose (200 mg/kg b.w.) was more effective than the higher dose 400 mg/kg b.w. in reducing serum dysfunction biomarker enzymes. The histopathological studies of liver tissues also showed better hepatoprotective activity of Piper chaba roots at the lower dose (200 mg/kg b.w.). Paracetamol induced hepatotoxicity in rats resulted in increase of antioxidant enzyme activities such as catalase, super oxide dismutase. The scavenging activity of P. chaba extract was moderate when compared with standard catechin and the IC50 values of P. chaba and standard catechin were 1.563 ± 0.70 and 3.125 ± 0.676, respectively in DPPH radical scavenging assay. The total antioxidant potential of P. chaba was concentration dependent and revealed promising antioxidant activity as compared to the reference standard catechin. At a concentration of 100 μg/mL the absorbance of P. chaba extract and catechin were 0.430 and 0.746 respectively. The research result indicated that P. chaba extract has protective effects on paracetamol induced oxidative stress and liver damage. 展开更多
关键词 PIPER chaba Antioxidant HEPATOPROTECTION Oxidative Damage
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表征抗氧化剂活性的ORAC法 预览
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作者 王会 《河南化工》 CAS 2019年第9期12-16,共5页
ORAC(氧自由基吸收能力)法可用于表征从蔬菜、水果、草药等植物中提取的生物活性物质的抗氧化活性。该法的自由基由AAPH提供,反应所用荧光探针可用B-藻红蛋白或荧光素,抗氧化活性用曲线下净面积法定量,用ORAC值表示,以Trolox作为标准抗... ORAC(氧自由基吸收能力)法可用于表征从蔬菜、水果、草药等植物中提取的生物活性物质的抗氧化活性。该法的自由基由AAPH提供,反应所用荧光探针可用B-藻红蛋白或荧光素,抗氧化活性用曲线下净面积法定量,用ORAC值表示,以Trolox作为标准抗氧化剂。ORAC法既可用于测定植物来源的抗氧化剂的活性,也可用于测定生物样品的活性。 展开更多
关键词 抗氧化剂 抗氧化活性 ORAC法
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Antioxidant, Cytotoxic, Thrombolytic and Antimicrobial Activity of <i>Zanthoxylum rhetsa</i>Root Bark with Two Isolated Quinolone Alkaloids 预览
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作者 Fatema Tuz Zohora Sheikh Nazrul Islam +2 位作者 Shibbir Ahmed Khan Choudhury Mahmood Hasan Monira Ahsan 《药理与制药(英文)》 2019年第3期137-145,共9页
The background of this study was to investigate the antioxidant, cytotoxic, thrombolytic and antimicrobial activity of the petroleum ether (PE), carbon tetrachloride (CTC), chloroform (CF) and aqueous (AQ) soluble fra... The background of this study was to investigate the antioxidant, cytotoxic, thrombolytic and antimicrobial activity of the petroleum ether (PE), carbon tetrachloride (CTC), chloroform (CF) and aqueous (AQ) soluble fractions of crude methanolic Zanthoxylum rhetsa root bark with two isolated quinolone alkaloids, 8-methoxy-n-methylflindersine (1) and zanthodioline (2). Structures were characterized by 1D NMR analyses. Antioxidant activity was assessed by using DPPH assay and antimicrobial activity was screened by disc diffusion method. An in vitro thrombolytic model was used to evaluate the clot lysis effect of different extracts of root bark of Z. rhetsa along with streptokinase as a positive control and distilled water as a negative control and the cytotoxic activity of different extracts of Z. rhetsa root bark was evaluated by Brine Shrimp Lethality Bioassay. AQ fraction exhibited strongest antioxidant, cytotoxic and thrombolytic activity among four fractions. The CTC and CF soluble fractions exhibited significant antioxidant, cytotoxic and thrombolytic activity. CTC and AQ fractions gave highest anti-bacterial activity against Vibrio cholera and Klebsiella pneumonia respectively. Compound 1 showed significant activity at a concentration of 100 μgm/disc against Sarcina lutea, Staphylococcus aureus and Salmonella paratyphi-A, Shigella dysenteriae, Shigella boydii and Shigella sonnei with high antioxidant activity. The antioxidant, thrombolytic and antimicrobial activity of 8-methoxy-n-methylflindersine and zanthodioline are the first record from root bark of this plant. 展开更多
关键词 ZANTHOXYLUM rhetsa ANTIOXIDANT THROMBOLYTIC Antimicrobial 8-Methoxy-n-Methylflindersine Zanthodioline
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Nrf2-inducing and HMG-CoA reductase inhibitory activities of a polyphenol-rich fraction of Guazuma ulmifolia leaves
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作者 Sulistiyani Syamsul Falah +5 位作者 Wulan Tri Wahyuni Dimas Andrianto Arthur Ario Lelono Waras Nurcholis Valeri Mossine Mark Hannink 《亚太热带生物医学杂志:英文版》 CAS 2019年第9期389-396,共8页
Objective: To fractionate and identify polyphenols from Guazuma ulmifolia Lam. leaves, and to explore their antioxidant, 5-hydroxy-3-methylglutaryl-coenzyme A(HMG-Co A) reductase inhibitory, and Nrf2 modulatory activi... Objective: To fractionate and identify polyphenols from Guazuma ulmifolia Lam. leaves, and to explore their antioxidant, 5-hydroxy-3-methylglutaryl-coenzyme A(HMG-Co A) reductase inhibitory, and Nrf2 modulatory activities.Methods: The 1,1-diphenyl-2-picrylhydrazyl assay was used to evaluate the antioxidant activity of a polyphenolic fraction of the extract of Guazuma ulmifolia Lam. leaves. THP-1 gene reporter cell lines constructed with a transcriptional response element specific for Nrf2 and a minimal promoter for the firefly luciferase–green fluorescent protein transgene were used to determine the effect of the polyphenolic fraction on the Nrf2 signaling pathway. Furthermore, an assay of HMG-Co A reductase inhibitory activity was performed by using a commercial enzyme kit. Polyphenolic compounds were identified by liquid chromatographytandem mass spectrometry.Results: The polyphenolic fraction showed fairly strong antioxidant activity [IC50 =(14.90 ± 4.70) μg/m L] and inhibited HMG-Co A reductase activity by 69.10%, which was slightly lower than that by pravastatin(84.37%) and quercetin(84.25%). Additionally, the polyphenolic fraction activated the Nrf2 antioxidant signaling pathway at 500 μg/m L. Eleven subfractions resulting from the column chromatography separation of the polyphenolic fraction also showed relatively strong antioxidant activities(IC50: 17.46–217.14 μg/m L). The subfraction(F6) stimulated the Nrf2 signaling pathway and had HMG-Co A reductase inhibitory activity(65.43%). Moreover, the subfraction contained two main flavonoids: quercetin and quercimeritrin.Conclusions: The polyphenolic fraction of Guazuma ulmifolia could induce antioxidant genes via the Nrf2/antioxidant regulatory elements pathway, and is a promising candidate for an inhibitor of HMG-Co A reductase. 展开更多
关键词 ANTIOXIDANT signaling HMG-Co A REDUCTASE inhibitor POLYPHENOLS Antioxidant-related transcription factor NRF2 REPORTER gene cell-based assay
Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i>Varieties Cultivated in Senegal 预览
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作者 A?ssatou Alioune Gaye Oumar Ibn Khatab Cisse +3 位作者 Bou Ndiaye Nicolas Cyrille Ayessou Mady Cisse Codou Mar Diop 《食品与营养科学(英文)》 2019年第3期276-289,共14页
The aqueous extracts of different parts (old leaves (OL), young leaves (YL), peels (PE) and delipidated seed residues (DS)) of three varieties of papaya are studied. Extraction conditions are optimized: an extraction ... The aqueous extracts of different parts (old leaves (OL), young leaves (YL), peels (PE) and delipidated seed residues (DS)) of three varieties of papaya are studied. Extraction conditions are optimized: an extraction time of 20 minutes, a temperature of 70°C and a plant material/water mixture of 1% give the best yield of polyphenol. The amount of polyphenols, flavonoids, saponins and proanthocyanins of each aqueous extract was investigated. Antioxidant activities are measured using two different methods (DPPH and ABTS). The delipidated seeds (DS) of V1 have the highest total phenolic content (TPC = 72.56 ± 3.16 mg GAE/g) while they have the lowest total flavonoid content (TFC = 0.22 ± 0.01). With regard to saponins, the PE of V3 is much richer in saponins (194.03 ± 15.78 mg AeE/g) than all the other extracts studied. The OL of V2 and PE of V1 contain the most proanthocyanidins with very similar values of 2.51 ± 0.03 mg CE/g and 2.53 ± 0.34 mg CE/g respectively. The study of the antioxidant activities of the extracts showed a correlation between the amount of polyphenols and IC50. DPPH OL and YL V2, which are rich in polyphenols, have the lowest IC50 of 0.072 mg/ml and 0.080 mg/ml respectively, whereas for ABTS we have PE of V1 that is very rich in polyphenols which has the smallest IC50 value of 0.218 mg/ml. 展开更多
关键词 CARICA PAPAYA Extraction Antioxidant Polyphenols Flavonoids PROANTHOCYANIDINS SAPONINS
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Influence of Cold Storage on the Bioactivity Properties and the Quality of the Juice of Moro Blood Orange (<i>Citrus sinensis</i>(L.) Osbeck) 预览
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作者 Maísa Lamounier Magalh?es Luiz Carlos De Oliveira Lima +8 位作者 Allan da Silva Lunguinho Danubia Aparecida De Carvalho Selvati Rezende Vanuzia Rodrigues Fernandes Ferreira Rafaela Magalh?es Brand?o Josefina Aparecida De Souza Ellen Cristina De Souza Kátia Júlia De Almeida David Lee Nelson Maria Das Gra?as Cardoso 《美国植物学期刊(英文)》 2019年第1期24-37,共14页
The possibility of commercialization of Moro blood oranges in tropical countries such as Brazil was evaluated to verify whether post-harvest management through storage at low temperatures for a period of 60 days can i... The possibility of commercialization of Moro blood oranges in tropical countries such as Brazil was evaluated to verify whether post-harvest management through storage at low temperatures for a period of 60 days can improve the bioactive properties and quality parameters. Moro blood oranges cultivated in Brazil did not contain significant amounts of anthocyanins at the time of harvesting, but these compounds were activated by post-harvest management through storage at low temperatures (4&deg;C and 8&deg;C) for a period of 60 days. The emergence of the anthocyanins in the juices occurred within a few weeks of storage, but the maximum levels were attained after 60 days and at the temperature of 8&deg;C. Cold storage positively influenced other bioactive compounds such as total phenolic compounds, individual phenolic compounds, β-carotene and the antioxidant activity determined by the sequestration of DPPH free radicals. It did not influence the vitamin C content. In addition, storage significantly altered the color, total acidity and pH of the fruits, but it did not prevent its commercial use. The remaining quality parameters were not influenced. It is possible to commercialize these oranges in Brazil through post-harvest management. 展开更多
关键词 Cyanidin-3-Glycoside Antioxidant POST-HARVEST
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慢性阻塞性肺疾病患者采取抗氧化剂治疗对营养状态、抗氧化指标的影响 预览
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作者 卢浩青 卢盛位 +1 位作者 谢峰 徐志远 《中外医疗》 2019年第15期100-102,118共4页
目的观察慢性阻塞性肺疾病患者采取抗氧化剂治疗对营养状态、抗氧化指标的影响。方法采用随机数字表法将方便选取该院2017年3月-2018年3月收入的110例慢性阻塞性肺疾病患者分为采取常规治疗的对照组及加用抗氧化剂治疗的观察组各55例,... 目的观察慢性阻塞性肺疾病患者采取抗氧化剂治疗对营养状态、抗氧化指标的影响。方法采用随机数字表法将方便选取该院2017年3月-2018年3月收入的110例慢性阻塞性肺疾病患者分为采取常规治疗的对照组及加用抗氧化剂治疗的观察组各55例,对两组营养状态、抗氧化状态、不良反应发生率进行比较。结果治疗后观察组体质量指数(24.91±1.01)kg/m^2、白蛋白(43.25±1.25)g/L、球蛋白(30.30±1.35)g/L、总抗氧化能力(560.89±7.22)μm、血浆还原型谷胱甘肽(1.34±0.21)μm,对照组体质量指数(24.10±1.04)kg/m^2、白蛋白(40.20±1.20)g/L、球蛋白(27.33±1.33)g/L、总抗氧化能力(535.41±7.29)μm、血浆还原型谷胱甘肽(0.98±0.22)μM,两组相比较,观察组均高于对照组,差异有统计学意义(t=0.697、1.021、1.020、1.789、0.691,P<0.05);观察组不良反应发生率9.09%,与对照组不良反应发生率7.27%差异无统计学意义(χ^2=0.221,P>0.05)。结论给予慢性阻塞性肺疾病患者抗氧化剂治疗有助于进一步改善其营养状态和抗氧化指标,值得推广使用。 展开更多
关键词 慢性阻塞性肺疾病 抗氧化剂 营养状态 抗氧化指标
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Antioxidant, Some Flavor Components, Microbiological and Microstructure Characteristics of Corn Milk Yoghurt 预览
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作者 Ateteallah Hassan Ateteallah Amna Abul-Kasem Abbas Osman 《食品与营养科学(英文)》 2019年第5期551-560,共10页
Corn milk is considered as a new innovation especially in the making of yoghurt based products. The present study was conducted to study antioxidants components such as (phenols compounds and DPPH scavenging activity)... Corn milk is considered as a new innovation especially in the making of yoghurt based products. The present study was conducted to study antioxidants components such as (phenols compounds and DPPH scavenging activity), total volatile free fatty acids, microbiological and microstructure characteristics in yoghurt samples produced from two different ratios of buffalos and corn milk (70:30 coded A and 60:40 coded B) respectively. Results indicated that the increasing ratio of corn milk led to increase the content of phenolic components and DPPH scavenging activity. Total viable content decreased in samples (70:30 and 60:40). Streptococci and lactobacilli count decreased by the increase of corn milk in produced samples. Results also show that the trend of yeasts content was the opposite ones. Election microscopy examination revealed that adding corn milk to yoghurt had more smoothly and systematically distributed casein with a bit coarse structure less porosity in the network of casein. From these results could be concluded that adding 40% corn milk during processing of yoghurt is increasing the antioxidant activity and improves the microstructure as well. 展开更多
关键词 CORN MILK YOGHURT ANTIOXIDANT Microstructure
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A Comparison Study of Phenolic Contents and <i>in Vitro</i>Antioxidant Activities of Australian Grown Faba Beans (<i>Vicia faba</i>L.) Varying in Seed Coat Colours as Affected by Extraction Solvents 预览
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作者 Siem Doo Siah Samson Agboola +2 位作者 Jennifer A. Wood Izabela Konczak Christopher L. Blanchard 《美国分析化学(英文)》 2019年第6期227-245,共19页
Twelve Australian grown faba bean genotypes with seed colour ranging from white, different shades of buff/beige, green, red and purple, were extracted using 80% methanol (v/v) or 70% acetone (v/v). The findings showed... Twelve Australian grown faba bean genotypes with seed colour ranging from white, different shades of buff/beige, green, red and purple, were extracted using 80% methanol (v/v) or 70% acetone (v/v). The findings showed that commonly consumed buff-coloured genotypes have comparable phenolic contents and antioxidant activities to those with exotic seed coat colour (red, green and purple). In general, the extraction yield for methanol and acetone extracts of faba bean genotypes were similar. However, the acetone extracts of faba bean varieties with coloured seed coats exhibited higher antioxidant activities than their methanol extracts counterparts. Phenolic compounds and antioxidant activities of the genotypes were compared in an array of chemical-based assays and profiled using an on-line high-performance liquid chromatography-post column derivatization (HPLC-PCD) system. The total phenolic content (TPC) and total flavonoid content (TFC) of acetone extracts were approximately twice those of methanol extracts. The acetone extracts contained six times higher levels of di(phenyl)-(2,4,6-trinitrophenyl) imi- noazanium radical scavenging activity (DPPH), six times higher Total Equivalent Antioxidant Capacity (TEAC) and two times higher Ferric Reducing Antioxidant Power (FRAP) than those of methanol extracts. In general, the methanol extracts of white-coloured faba bean genotype exhibited comparable phenolic contents and antioxidant activities to varieties with coloured seed coats. However, the TPC, TFC, DPPH, TEAC and FRAP of acetone extracts from white-coloured genotype were 2 - 4, 1 - 2, 5 - 9, 2 - 3 and 1 - 2 times lower than those of faba bean varieties with coloured seed coats. HPLC-PCD analyses showed substantial antioxidant responses, represented as a dense “hump” of peaks in the HPLC chromatograms of acetone extracts from coloured-genotypes. This “hump” was not detected in the chromatograms of white-genotype acetone extracts, or in chromatograms of methanol extracts regardless of genotype or seed coat co 展开更多
关键词 VICIA faba Extraction Solvent Phenolic Compound ANTIOXIDANT
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Effects of saccharicterpenin on antioxidant status and urinary metabolic profile of rats
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作者 Guangmang Liu Jie Zheng +5 位作者 Xianjian Wu Gang Jia Hua Zhao Xiaoling Chen Caimei Wu Jing Wang 《动物营养:英文版》 2019年第2期191-195,共5页
Saccharicterpenin is a new green additive agent that is derived from the extract of Theaceae plants and has the ability to improve immunity and meat quality, increase the digestive enzyme activity, and enhance the int... Saccharicterpenin is a new green additive agent that is derived from the extract of Theaceae plants and has the ability to improve immunity and meat quality, increase the digestive enzyme activity, and enhance the intestinal development and growth of animals. However, the antioxidant status and systematic changes in metabolic biochemistry associated with saccharicterpenin supplementation in animals are still unknown. This study examined the effects of saccharicterpenin on the antioxidant status and urinary metabolic profile of rats. Sixteen rats were randomly distributed to 2 groups. One group was treated with 400 mg/kg body weight of saccharicterpenin, and the other group was treated with equal amount of saline. Results revealed that saccharicterpenin significantly increased the capacities of antihydroxyl radical(13.18%) and anti-superoxide anion(14.36%), the total antioxidant capacity(48.27%),and the activities of total superoxide dismutase(3.68%), catalase(21.52%), glutathione peroxidase(5.83%)and glutathione S-transferase(29.59%)(P < 0.05). By contrast, the contents of malondialdehyde and glutathione were not significantly affected by saccharicterpenin(P > 0.05). Saccharicterpenin supplementation significantly increased the urinary levels of bile acids, ethanol. α-ketoglutarate, and a-hydroxy butyrate but decreased the level of N-acetylglutamate(P < 0.05). In summary, saccharicterpenin can enhance the antioxidant capacity and modulate the metabolism in rats. 展开更多
关键词 Saccharicterpenin ANTIOXIDANT ANTIOXIDANT STATUS METABOLIC profile METABOLISM URINE
Nectandra acutifolia(Ruiz&Pav.)Mez(Lauraceae)Reduces Oxidative Stress Induced with Rotenone in Drosophila melanogaster 预览
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作者 Lina María González Oscar Marino Mosquera 《药剂与药理学:英文版》 2019年第12期599-610,共12页
The increase in the population of neurodegenerative diseases has made it necessary to search for new drugs and phytopharmaceuticals for the prevention or treatment of these diseases,which is why the exploration of the... The increase in the population of neurodegenerative diseases has made it necessary to search for new drugs and phytopharmaceuticals for the prevention or treatment of these diseases,which is why the exploration of the potential of the plants present in the coffee zone is of great importance.The objective of this study was to determine the possible neuroprotective effect of the species Nectandra acutifolia.The methanolic extract of Nectandra acutifolia was obtained through maceration of the aerial part of the leaves.The phytochemical profile was detected by means of thin layer chromatography.The evaluation of the antioxidant capacity was carried out by means of the colorimetric techniques of DPPH•and ABTS•^+.On the other hand,the total content of phenols and flavonoids was determined as well as the neuroprotective activity,by means of the negative geotaxis test and biochemical tests.Finally,the methanolic extract of N.acutifolia showed a high antioxidant capacity through the two colorimetric methods.The negative geotaxis test revealed that the concentration of 0.1%had a greater locomotor effect in D.melanogaster,which was used as a supplement in the feeding of the Drosophilas.The results showed that the methanolic extract of this species has neuroprotective activity using this in vivo model. 展开更多
关键词 Antioxidant activity neuroptotection Nectandra acutifolia antioxidant capacity locomotive capacity negative geotaxis
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Modulations in Anti-Oxidant Activities of Selected Gastro-Intestinal Tissues in Alloxan-Induced, Silymarin Treated Diabetic Wistar Rats 预览
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作者 Johnson Uyovwiesevwa Ataihire Eze Kingsley Nwangwa John Chukwuka Igweh 《肠胃病学期刊(英文)》 2019年第5期73-90,共18页
Diabetes mellitus (DM) is reportedly the commonest metabolic disorder with multi organ involvement. By inducing DM (with Alloxan) in Wistar rats, current study investigated the changes in antioxidant activities of sel... Diabetes mellitus (DM) is reportedly the commonest metabolic disorder with multi organ involvement. By inducing DM (with Alloxan) in Wistar rats, current study investigated the changes in antioxidant activities of selected gastrointestinal (GI) tissues [stomach, duodenum, pancreas and liver], upon treatment with Silymarin and/or Vitamin C. One hundred and twenty five (125) adult male wistar rats of between 130 to 180 grams were procured for the study. Five units of one control and four experimental units were designated with twenty five (25) rats per group (n = 25);Unit 1: Control rats, Unit 2 were DM induced, Silymarin untreated rats, and Units 3, 4 and 5 were DM induced, vitamin C, Silymarin and Vitamin C + Silymarin treated respectively. Following four (4) weeks of administration of test substance(s), rats were euthanized and blood samples obtained for biochemical and antioxidant assay on aforementioned GI tissues. One way analysis of variance (ANOVA) and Students t-test at p p < 0.05) at comparison of extract treated unit to control. Study also observed a significant change in pancreatic, liver, and duodenal anti-oxidant marker levels with Vitamin C, Silymarin and Vitamin C + Silymarin co-administrations to diabetic rats. It can therefore be said, that DM caused a destructive alteration pancreatic histo-architecture with improved functional capabilities in wistar rats at administration of Silymarin and vitamin C. Thus, Silymarin posed antioxidant potentials, with ameliorated pancreatic dysfunctions. 展开更多
关键词 SILYMARIN Antioxidant Diabetes MELLITUS
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Effects of Processing on Antioxidant Capacity and Metabolizing Enzyme Inhibition of Tiger Nut Tubers 预览
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作者 Shantrell Willis Cydney Jackson Martha Verghese 《食品与营养科学(英文)》 2019年第9期1132-1141,共10页
Tiger nut (Cyperus esculentus), commonly referred to as chufa, is a “nut-like” tuber, native to tropical and Mediterranean regions. It is often consumed in the form of a beverage (horchata de chufa). Health benefits... Tiger nut (Cyperus esculentus), commonly referred to as chufa, is a “nut-like” tuber, native to tropical and Mediterranean regions. It is often consumed in the form of a beverage (horchata de chufa). Health benefits of tiger nut have been attributed to presence of phytochemicals and their antioxidant potential. Tiger nut is often processed in order to enhance sensory characteristics. The objective of study was to determine effects of processing on antioxidant content, potential and inhibition of metabolizing enzyme activities of tiger nuts. Total phenolic content (TPC), total flavonoid content (TFC), free radical scavenging activity by 1,1-diphenyl-2-picryhydrazyl (DPPH), trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant power (FRAP) and inhibition of lipase and α-amylase were evaluated in raw tiger nuts extracted with water (TRWA) and methanol (TRWM) and roasted (110&deg;C – 115&deg;C for 10 mins) tiger nuts extracted with water (TRA) and methanol (TRM). Highest phenolic content was observed in TRWA (1186.68 GAE/100g) and TRWM had lowest (43.77 GAE/100g). TRWA also exhibited highest ferric reducing ability with a FRAP value of 169.83 mm Fe2+/100g). TRWM had a higher flavonoid content (220.68 CAE/100g) compared to all other extracts. At a concentration of 0.02 mg/ml, all extracts reached at least 50% inhibition of DPPH, while highest scavenging activity was observed in TRM (58%). Highest TEAC was observed in TRM with 55.66% of ABTS radical scavenged. TRA had a significantly higher ability to inhibit α-amylase and lipase compared to other extracts. Results suggest that processing had an effect on the antioxidant potential of tiger nut, and this tuber may benefit consumers by improving their antioxidant status. 展开更多
关键词 ANTIOXIDANT TUBER ENZYME
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Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing <i>in Vitro</i>Fertilization for Unexplained Infertility 预览
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作者 Ayse Z. Ozdemir Bulent Ayas +2 位作者 Davut Guven Abdulkadir Bakay Pervin Karl? 《妇产科期刊(英文)》 2019年第1期1-9,共9页
Objective: This is a retrospective study to evaluate the effect of using the antioxidants containing coenzyme Q10 (CoQ10) and omega-3 in patients undergoing in vitro fertilization and intracytoplasmic sperm injection ... Objective: This is a retrospective study to evaluate the effect of using the antioxidants containing coenzyme Q10 (CoQ10) and omega-3 in patients undergoing in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) for unexplained infertility. Materials Methods: A total of 299 patients undergoing IVF-ICSI for unexplained infertility at the IVF center of Ondokuz Mayis University were studied. The subject group consisted of 135 patients who used OMEPA Q10 (Co Q10 100 mg, omega-3 600 mg, eicosapentaenoic acid 300 mg, docosahexaenoic acid 230 mg) for two months before ovarian stimulation. A group of 164 patients who did not use the supplement were evaluated as the control group. Results: The pregnancy rate of patients using antioxidants was statistically higher than that of those who did not use the supplement (p 0.05). The pregnancy rates of patients in the two groups were 32.9% and 49.6% respectively. The pregnancy rate of patients using antioxidants was statistically higher than that of those who did not use the supplement (p 0.05) seemed not enough. Conclusion: We concluded that using antioxidants that contain Co Q10 and omega-3 in patients undergoing IVF-ICSI for unexplained infertility increased the clinical pregnancy rate. We recommend using antioxidants that contain Co Q10 and omega-3 in infertile patients. 展开更多
关键词 CoQ10 Omega-3 ANTIOXIDANT UNEXPLAINED INFERTILITY In Vitro FERTILIZATION
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Impact of Drought Stress during Germination on Antioxidant Capacities and Antioxidant Enzymes Activities of Madura Local Maize (<i>Zea mays</i>) Seeds 预览
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作者 Agnes Rezkyta Herwang Dani Tri Agus Siswoyo 《农业科学(英文)》 2019年第11期1506-1516,共11页
The effect of various polyethylene glycol (PEG) concentrations to induced drought stress on the antioxidant capacities and antioxidant enzyme activities was investigated on Madura local maize during germination. Seed ... The effect of various polyethylene glycol (PEG) concentrations to induced drought stress on the antioxidant capacities and antioxidant enzyme activities was investigated on Madura local maize during germination. Seed samples were treated under 5%, 10%, and 15% of PEG for 6 days. The changes in the antioxidant capacities such as 2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) and hydroxyl radical scavenging;antioxidant enzyme activities including catalase (CAT) and ascorbate peroxidase (APX) and gene expression were observed during seeds germination. The result showed the antioxidants capacities and enzyme activities exhibited a significantly higher level in drought-treated. The most effective level of drought stress to elevate the capabilities and enzyme activity of antioxidant as well as it gene expression was observed at 15% PEG, whereas ABTS scavenging activity was increased 20% over the control, hydroxyl scavenging activity up to 14%, CAT and APX activity increased 4 - 5 times over the control. Along with the presence of antioxidant mechanisms, including the capacities and activities of different types of ABTS+, hydroxyl, CAT, and APX might play important roles during the germination phase and be able to manage reactive oxygen species to the normal level under stress condition. 展开更多
关键词 Drought ANTIOXIDANT GERMINATION MAIZE Polyethylene-Glycol
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聚碳酸酯材料耐热氧老化性能的研究 预览
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作者 安平 陈金彪 +2 位作者 郭开 李楠 于小龙 《塑料助剂》 2019年第3期29-32,共4页
通过热老化实验和多次基础实验,评估不同抗氧剂,包括主抗氧剂和辅助抗氧剂对聚碳酸酯耐热老化性能的影响。实验结果表明,较传统抗氧剂,添加受阻酚类主抗氧剂AO-1后聚碳酸酯135℃老化168h后的YI变化值只有3.66;添加亚磷酸酯类辅助抗氧剂A... 通过热老化实验和多次基础实验,评估不同抗氧剂,包括主抗氧剂和辅助抗氧剂对聚碳酸酯耐热老化性能的影响。实验结果表明,较传统抗氧剂,添加受阻酚类主抗氧剂AO-1后聚碳酸酯135℃老化168h后的YI变化值只有3.66;添加亚磷酸酯类辅助抗氧剂AO-5后聚碳酸酯多次挤出测试后熔体流动速率变化只有3.68;添加硫代酯类辅助抗氧剂AO-6后聚碳酸酯135℃老化168h后的YI变化值只有1.03;AO-1+AO-5+AO-6是提升聚碳酸酯长效热稳定性和加工稳定性最优搭配。 展开更多
关键词 抗氧化剂 聚碳酸酯 抗老化
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