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Neuroprotective effects of minocycline on focal cerebral ischemia injury:a systematic review 预览
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作者 Yazdan Naderi Yunes Panahi +1 位作者 George E. Barreto Amirhosein Sahebkar 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期773-782,共10页
To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of... To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of the study.Studies were included if focal cerebral ischemia model was performed in mammals and including a control group that has been compared with a minocycline group.Written in languages other than English;duplicate data;in vitro studies and combination of minocycline with other neuroprotective agents were excluded.Neurological function of patients was assessed by National Institute of Health Stroke Scale,modified Rankin Scale,and modified Barthel Index.Neuroprotective effects were assessed by detecting the expression of inflammatory cytokines.We examined 35 papers concerning the protective effects of minocycline in focal cerebral ischemia in animal models and 6 clinical trials which had evaluated the neuroprotective effects of minocycline in ischemic stroke.These studies revealed that minocycline increases the viability of neurons and decreases the infarct volume following cerebral ischemia.The mechanisms that were reported in these studies included anti-inflammatory,antioxidant,as well as anti-apoptotic effects.Minocycline also increases the neuronal regeneration following cerebral ischemia.Minocycline has considerable neuroprotective effects against cerebral ischemia-induced neuronal damages.However,larger clinical trials may be required before using minocycline as a neuroprotective drug in ischemic stroke. 展开更多
关键词 ISCHEMIC STROKE MINOCYCLINE NEURONAL REGENERATION NEUROPROTECTION STROKE
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Neuroprotective mechanism of TMP269, a selective class ⅡA histone deacetylase inhibitor, after cerebral ischemia/reperfusion injury 预览
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作者 Lu Su Dan Liang +3 位作者 Shen-Yi Kuang Qiang Dong Xiang Han Zheng Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期277-284,共8页
TMP269 is a selective class ⅡA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of ... TMP269 is a selective class ⅡA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of TMP269 for protecting against cerebral ischemia/reperfusion injury and its neuroprotective mechanism. Male Sprague-Dawley rats were randomly divided into sham, ischemia/reperfusion, and 1, 4, 10 and 16 mg/kg TMP269 groups. Cerebral ischemia/reperfusion injury was induced by middle cerebral artery occlusion. TMP269 was intraperitoneally administered at different doses 0.5 hours before ischemia induction. Western blot assay and immunohistochemistry were used to detect effects of TMP269 on histone 2 acetylation. The results showed that the level of histone 2 acetylation was increased 24 hours after TMP269 injection. 2,3,5-Triphenyltetrazolium chloride staining was utilized to examine effect of TMP269 on infarct volume. The results found that different doses of TMP269 could reduce the infarct volume. Western blot assay, immunohistochemistry and Evans blue staining were employed to measure the effect of TMP269 on blood-brain barrier. The results showed that TMP269 counteracted the abnormal endothelial cell permeability changes caused by cerebral ischemia/reperfusion. Western blot assay and immunohistochemistry were used to determine the effect of TMP269 on tissue kallikrein. The results found that TMP269 up-regulated the expression of tissue kallikrein. Western blot assay further determined the optimal concentration to be 4 mg/kg. In conclusion, TMP269 plays a neuroprotective role by up-regulating the level of histone 2 acetylation, alleviating endothelial cell injury after cerebral ischemia/reperfusion, and up-regulating the expression of tissue kallikrein. The experimental protocol was approved in 2014 by the Department of Laboratory Animal Science, Fudan University, China(approval No. 20140143 C001). 展开更多
关键词 blood-brain barrier drug treatment endothelial cell permeability HISTONE DEACETYLASE inhibitor NEUROPROTECTION stroke tissue KALLIKREIN TMP269
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推拿配合针刺治疗中风后气虚便秘的效果及安全性研究 预览
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作者 王艺达 梁爽 马赟 《中华养生保健》 2020年第1期72-73,共2页
目的探讨推拿配合针刺治疗中风后气虚便秘患者的效果与安全性。方法选取河南中医药大学第三附属医院于2018年6月至2019年6月期间收治的100例中风后气虚便秘患者为研究对象,采用随机数表法分为两组,对照组(n=50)采用口服福松治疗,观察组(... 目的探讨推拿配合针刺治疗中风后气虚便秘患者的效果与安全性。方法选取河南中医药大学第三附属医院于2018年6月至2019年6月期间收治的100例中风后气虚便秘患者为研究对象,采用随机数表法分为两组,对照组(n=50)采用口服福松治疗,观察组(n=50)采用推拿配合针刺治疗,分析两组治疗前后各症状积分以及不良反应发生率。结果观察组各症状积分以及不良反应发生率相较于对照组均明显降低,差异有统计学意义(P<0.05)。结论推拿配合针刺治疗中风后气虚便秘患者效果较好,不良反应较少,安全性较高,建议临床应用。 展开更多
关键词 推拿 针刺 中风 气虚便秘
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Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction 预览
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作者 Dao-Xia Guo Zheng-Bao Zhu +12 位作者 Chong-Ke Zhong Xiao-Qing Bu Li-Hua Chen Tan Xu Li-Bing Guo Jin-Tao Zhang Dong Li Jian-Hui Zhang Zhong Ju Chung-Shiuan Chen Jing Chen Yong-Hong Zhang Jiang He 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期922-928,共7页
Stroke is the leading cause of death and long-term disability worldwide,and cognitive impairment and dementia are major complications of ischemic stroke.Cystatin C (CysC) has been found to be a neuroprotective factor ... Stroke is the leading cause of death and long-term disability worldwide,and cognitive impairment and dementia are major complications of ischemic stroke.Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies.However,the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different results.This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months.Data from 638 patients were obtained from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS).Cognitive dysfunction was assessed using the Mini-Mental State Examination (MMSE) at 3 months after stroke.According to the MMSE score,308 patients (52.9%) had post-stroke cognitive dysfunction.After adjusting for potential confounding factors,the odds ratio (95% CI) of post-stroke cognitive dysfunction for the highest quartile of serum CysC levels was 0.54 (0.30–0.98),compared with the lowest quartile.The correlation between serum CysC and cognitive dysfunction was modified by renal function status.We observed a negative linear dose-response correlation between CysC and cognitive dysfunction in patients with normal renal function (Plinearity = 0.044),but not in those with abnormal renal function.Elevated serum CysC levels were correlated with a low risk of 3-month cognitive dysfunction in patients with acute ischemic stroke,especially in those with normal renal function.The current results suggest that CysC is a protective factor for post-stroke cognitive dysfunction,and could be used to treat post-stroke cognitive dysfunction.The CATIS study was approved by the Institutional Review Boards at Soochow University from China (approval No.2012-02) on December 30,2012,and was registered at ClinicalTrials.gov (identifier No.NCT01840072) on April 25,2013. 展开更多
关键词 abnormal RENAL FUNCTION cognitive dysfunction CYSTATIN C ischemic stroke Mini-Mental State Examination neural regeneration NEUROPROTECTIVE effect normal RENAL FUNCTION
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δ-Opioid receptor as a potential therapeutic target for ischemic stroke 预览
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作者 Kalpana Subedi Hongmin Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期20-24,共5页
Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels.Despite having advancement in the... Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels.Despite having advancement in the use of thrombolytic and clot removal medicine,significant numbers of stroke patients are still left out without option for treatment.In this review,we summarize recent research work on the activation ofδ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury.Moreover,as activation ofδ-opioid receptor by a non-peptidicδ-opioid receptor agonist also modulates the expression,maturation and processing of amyloid precursor protein andβ-secretase activity,the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed. 展开更多
关键词 AGONIST AKT AMYLOID precursor protein BDNF ischemic stroke NEUROPROTECTION δ-opioid receptor p38 MAPK PI3K TRKB
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Hydrogels for neuroprotection and functional rewiring:a new era for brain engineering 预览
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作者 Rocío Fernández-Serra Rebeca Gallego +1 位作者 Paloma Lozano Daniel González-Nieto 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期783-789,共7页
The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal pathologies.High-performance preclinical results have fai... The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal pathologies.High-performance preclinical results have failed at clinical level,as it has been the case for a wide variety of neuroprotective agents and cell-based therapies employed to treat high prevalent brain pathologies such as stroke,Alzheimer’s and Parkinson’s diseases.An unquestionable reality is the current absence of effective therapies to neuroprotect the brain,to arrest neurodegeneration and rewire the impaired brain circuits.Part of the problem might arise from the lack of adequate in vitro and in vivo models and that most of the underlying pathophysiological mechanisms are not yet clarified.Another contributing factor is the lack of efficient systems to sustain drug release at therapeutic concentrations and enhance the survival and function of grafted cells in transplantation procedures.For medical applications the use of biomaterials of different compositions and formats has experienced a boom in the last decades.Although the greater complexity of central nervous system has probably conditioned their extensive use with respect to other organs,the number of biomaterials-based applications to treat the injured brain or in the process of being damaged has grown exponentially.Hydrogel-based biomaterials have constituted a turning point in the treatment of cerebral disorders using a new form of advanced therapy.Hydrogels show mechanical properties in the range of cerebral tissue resulting very suitable for local implantation of drugs and cells.It is also possible to fabricate three-dimensional hydrogel constructs with adaptable mesh size to facilitate axonal guidance and elongation.Along this article,we review the current trends in this area highlighting the positive impact of hydrogel-based biomaterials over the exhaustive control of drug delivery,cell engraftment and axonal reinnervation in brain pathologies. 展开更多
关键词 advanced therapies Alzheimer’s DISEASE biomaterials BRAIN HYDROGELS NEUROLOGICAL diseases Parkinson’s DISEASE polymers stroke
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醒脑开窍药纯氧吸入治疗中风的临床效果观察 预览
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作者 董学荣 《基层医学论坛》 2020年第1期108-109,共2页
目的探讨醒脑开窍药纯氧吸入治疗中风的临床效果。方法将我院2017年1月—2019年5月接受治疗的中风患者52例利用随机数字表法分为2组各26例,对照组给予常规治疗,观察组在对照组基础上加用醒脑开窍药纯氧吸入治疗。对比2组治疗前后美国国... 目的探讨醒脑开窍药纯氧吸入治疗中风的临床效果。方法将我院2017年1月—2019年5月接受治疗的中风患者52例利用随机数字表法分为2组各26例,对照组给予常规治疗,观察组在对照组基础上加用醒脑开窍药纯氧吸入治疗。对比2组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分和治疗效果。结果治疗前2组NIHSS评分无统计学差异(P>0.05);治疗后均较治疗前明显降低,且观察组降低趋势更为显著(P<0.05)。观察组患者的临床治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。结论醒脑开窍药纯氧吸入治疗中风效果显著,能有效改善患者的神经功能缺损症状。 展开更多
关键词 中风 醒脑开窍药 纯氧吸入 治疗效果
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Angiogenesis and neuronal remodeling after ischemic stroke 预览
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作者 Masahiro Hatakeyama Itaru Ninomiya Masato Kanazawa 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期16-19,共4页
Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal models.This raises... Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal models.This raises the possibility that enhancement of angiogenesis is one of the strategies to facilitate functional recovery after ischemic stroke.Blood vessels and neuronal cells communicate with each other using various mediators and contribute to the pathophysiology of cerebral ischemia as a unit.In this mini-review,we discuss how angiogenesis might couple with axonal outgrowth/neurogenesis and work for functional recovery after cerebral ischemia.Angiogenesis occurs within 4 to 7 days after cerebral ischemia in the border of the ischemic core and periphery.Post-ischemic angiogenesis may contribute to neuronal remodeling in at least two ways and is thought to contribute to functional recovery.First,new blood vessels that are formed after ischemia are thought to have a role in the guidance of sprouting axons by vascular endothelial growth factor and laminin/β1-integrin signaling.Second,blood vessels are thought to enhance neurogenesis in three stages:1)Blood vessels enhance proliferation of neural stem/progenitor cells by expression of several extracellular signals,2)microvessels support the migration of neural stem/progenitor cells toward the peri-infarct region by supplying oxygen,nutrients,and soluble factors as well as serving as a scaffold for migration,and 3)oxygenation induced by angiogenesis in the ischemic core is thought to facilitate the differentiation of migrated neural stem/progenitor cells into mature neurons.Thus,the regions of angiogenesis and surrounding tissue may be coupled,representing novel treatment targets. 展开更多
关键词 ANGIOGENESIS AXONAL OUTGROWTH cerebral ischemia coupling functional recovery guidance NEUROGENESIS stroke
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Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke 预览
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作者 Bei Zhang Kathryn ESaatman Lei Chen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期416-424,共9页
Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmace... Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmaceuticals for stroke treatment.Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke,and highlight potential mechanisms underlying their therapeutic effects.It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways,thereby attenuating multiple aspects of ischemic pathology.We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke. 展开更多
关键词 cell death HERBAL compound immune response ISCHEMIC stroke therapy NEUROPLASTICITY NEUROPROTECTION oxidative damage traditional Chinese medicine
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Taking central nervous system regenerative therapies to the clinic:curing rodents versus nonhuman primates versus humans 预览
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作者 Magdalini Tsintou Kyriakos Dalamagkas Nikos Makris 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期425-437,共13页
The central nervous system is known to have limited regenerative capacity.Not only does this halt the human body’s reparative processes after central nervous system lesions,but it also impedes the establishment of ef... The central nervous system is known to have limited regenerative capacity.Not only does this halt the human body’s reparative processes after central nervous system lesions,but it also impedes the establishment of effective and safe therapeutic options for such patients.Despite the high prevalence of stroke and spinal cord injury in the general population,these conditions remain incurable and place a heavy burden on patients’families and on society more broadly.Neuroregeneration and neural engineering are diverse biomedical fields that attempt reparative treatments,utilizing stem cells-based strategies,biologically active molecules,nanotechnology,exosomes and highly tunable biodegradable systems(e.g.,certain hydrogels).Although there are studies demonstrating promising preclinical results,safe clinical translation has not yet been accomplished.A key gap in clinical translation is the absence of an ideal animal or ex vivo model that can perfectly simulate the human microenvironment,and also correspond to all the complex pathophysiological and neuroanatomical factors that affect functional outcomes in humans after central nervous system injury.Such an ideal model does not currently exist,but it seems that the nonhuman primate model is uniquely qualified for this role,given its close resemblance to humans.This review considers some regenerative therapies for central nervous system repair that hold promise for future clinical translation.In addition,it attempts to uncover some of the main reasons why clinical translation might fail without the implementation of nonhuman primate models in the research pipeline. 展开更多
关键词 animal models central nervous system regeneration clinical translation exosomes HYDROGELS neural tissue engineering nonhuman PRIMATES spinal cord injury stem cells stroke
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Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage 预览
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作者 Rais Reskiawan Abdulkadir Mansour Alwjwaj +2 位作者 Othman Ahmad Othman Kamini Rakkar Ulvi Bayraktutan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1071-1078,共8页
Breakdown of blood-brain barrier,formed mainly by brain microvascular endothelial cells(BMECs),represents the major cause of mortality during early phases of ischemic strokes.Hence,discovery of novel agents that can e... Breakdown of blood-brain barrier,formed mainly by brain microvascular endothelial cells(BMECs),represents the major cause of mortality during early phases of ischemic strokes.Hence,discovery of novel agents that can effectively replace dead or dying endothelial cells to restore blood-brain barrier integrity is of paramount importance in stroke medicine.Although endothelial progenitor cells(EPCs)represent one such agents,their rarity in peripheral blood severely limits their adequate isolation and therapeutic use for acute ischemic stroke which necessitate their ex vivo expansion and generate early EPCs and outgrowth endothelial cells(OECs)as a result.Functional analyses of these cells,in the present study,demonstrated that only OECs endocytosed DiI-labelled acetylated low-density lipoprotein and formed tubules on matrigel,prominent endothelial cell and angiogenesis markers,respectively.Further analyses by flow cytometry demonstrated that OECs expressed specific markers for sternness(CD34),immaturity(CD133)and endothelial cells(CD31)but not for hematopoietic cells(CD45).Like BMECs,OECs established an equally tight in vitro model of human BBB with astrocytes and pericytes,suggesting their capacity to form tight junctions.Ischemic injury mimicked by concurrent deprivation of oxygen and glucose(4 hours)or deprivation of oxygen and glucose followed by reperfusion(20 hours)affected both barrier integrity and function in a similar fashion as evidenced by decreases in transendothelial electrical resistance and increases in paracellular flux,respectively.Wound scratch assays comparing the vasculoreparative capacity of cells revealed that,compared to BMECs,OECs possessed a greater proliferative and directional migratory capacity.In a triple culture model of BBB established with astrocytes,pericytes and BMEC,exogenous addition of OECs effectively repaired the damage induced on endothelial layer in serum-free conditions.Taken together,these data demonstrate that OECs may effectively home to the site of vascular injury and re 展开更多
关键词 cell-based therapy endothelial progenitor cells ENDOTHELIUM ischemic stroke NEURODEGENERATION novel therapeutics outgrowth endothelial cells regenerative medicine stem cells translational medicine
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呼吸功能训练对脑卒中吞咽障碍患者吞咽功能的恢复作用 预览
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作者 李伟 《中华养生保健》 2020年第1期20-21,共2页
目的评价分析呼吸功能训练对脑卒中呑咽障碍患者呑咽功能的恢复作用的影响效果。方法选取于2017年7月至2018年7月期间黑龙江省农垦总局总医院收治的80例脑卒中呑咽障碍患者作为研究对象,患者根据入院先后顺序进行编号,并设置40例编号为... 目的评价分析呼吸功能训练对脑卒中呑咽障碍患者呑咽功能的恢复作用的影响效果。方法选取于2017年7月至2018年7月期间黑龙江省农垦总局总医院收治的80例脑卒中呑咽障碍患者作为研究对象,患者根据入院先后顺序进行编号,并设置40例编号为奇数号的患者为探究组和40例编号为偶数号的患者为对照组。予以对照组患者常规呑咽功能训练,探究组患者在对照组的基础上应用呼吸功能训练进行治疗,比较两组患者的治疗总有效率以及治疗前后的标准呑咽功能评分。结果治疗后,探究组患者治疗总有效率(97.50%)明显高于对照组患者(75.00%),组间数据对比差异具有统计学意义(P<0.05);治疗前探究组和对照组标准呑咽功能评分无显著性差异,,>0.05,治疗后探究组患者标准呑咽功能评分(17.56±3.21)分显著高于对照组的(24.01±5.65)分,组间数据对比差异具有统计学意义(P<0.05)。结论予以脑卒中呑咽障碍患者常规呑咽功能训练和呼吸功能训练进行治疗,效果显著,有很高的临床应用价值。 展开更多
关键词 呼吸功能训练 脑卒中 呑咽障碍 呑咽功能
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Effects of CXCR7-neutralizing antibody on neurogenesis in the hippocampal dentate gyrus and cognitive function in the chronic phase of cerebral ischemia 预览
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作者 Bing-Chao Dong Mei-Xuan Li +6 位作者 Xiao-Yin Wang Xi Cheng Yu Wang Ting Xiao Jukka Jolkkonen Chuan-Sheng Zhao Shan-Shan Zhao 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1079-1085,共7页
Stromal cell-derived factor-1 and its receptor CXCR4 are essential regulators of the neurogenesis that occurs in the adult hippocampal dentate gyrus.However,the effects of CXCR7,a new atypical receptor of stromal cell... Stromal cell-derived factor-1 and its receptor CXCR4 are essential regulators of the neurogenesis that occurs in the adult hippocampal dentate gyrus.However,the effects of CXCR7,a new atypical receptor of stromal cell-derived factor-1,on hippocampal neurogenesis after a stroke remain largely unknown.Our study is the first to investigate the effect of a CXCR7-neutralizing antibody on neurogenesis in the dentate gyrus and the associated recovery of cognitive function of rats in the chronic stage of cerebral ischemia.The rats were randomly divided into sham,sham+anti-CXCR7,ischemia and ischemia+anti-CXCR7 groups.Endothelin-1 was injected in the ipsilateral motor cortex and striatum to induce focal cerebral ischemia.Sham group rats were injected with saline instead of endothelin-1 via intracranial injection.Both sham and ischemic rats were treated with intraventricular infusions of CXCR7-neutralizing antibodies for 6 days 1 week after surgery.Immunofluorescence staining with doublecortin,a marker for neuronal precursors,was performed to assess the neurogenesis in the dentate gyrus.We found that anti-CXCR7 antibody infusion enhanced the proliferation and dendritic development of doublecortin-labeled cells in the dentate gyrus in both ischemic and sham-operated rats.Spatial learning and memory functions were assessed by Morris water maze tests 30-32 days after ischemia.CXCR7-neutralizing antibody treatment significantly reduced the escape latency of the spatial navigation trial and increased the time spent in the target quadrant of spatial probe trial in animals that received ischemic insult,but not in sham operated rats.These results suggest that CXCR7-neutralizing antibody enhances the neurogenesis in the dentate gyrus and improves the cognitive function after cerebral ischemia in rats.All animal experimental protocols and procedures were approved by the Institutional Animal Care and Use Committee of China Medical University(CMU16089 R)on December 8,2016. 展开更多
关键词 cerebral ischemia cognitive function CXCR7 dendritic development dentate gyrus DOUBLECORTIN NEUROGENESIS neutralizing antibody stroke stromal cell-derived factor-1
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Selective brain hypothermia-induced neuroprotection against focal cerebral ischemia/reperfusion injury is associated with Fis1 inhibition 预览
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作者 Ya-Nan Tang Gao-Feng Zhang +6 位作者 Huai-Long Chen Xiao-Peng Sun Wei-Wei Qin Fei Shi Li-Xin Sun Xiao-Na Xu Ming-Shan Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期903-911,共9页
Selective brain hypothermia is considered an effective treatment for neuronal injury after stroke,and avoids the complications of general hypothermia.However,the mechanisms by which selective brain hypothermia affects... Selective brain hypothermia is considered an effective treatment for neuronal injury after stroke,and avoids the complications of general hypothermia.However,the mechanisms by which selective brain hypothermia affects mitochondrial fission remain unknown.In this study,we investigated the effect of selective brain hypothermia on the expression of fission 1 (Fis1) protein,a key factor in the mitochondrial fission system,during focal cerebral ischemia/reperfusion injury.Sprague-Dawley rats were divided into four groups.In the sham group,the carotid arteries were exposed only.In the other three groups,middle cerebral artery occlusion was performed using the intraluminal filament technique.After 2 hours of occlusion,the filament was slowly removed to allow blood reperfusion in the ischemia/reperfusion group.Saline,at 4℃ and 37℃,were perfused through the carotid artery in the hypothermia and normothermia groups,respectively,followed by restoration of blood flow.Neurological function was assessed with the Zea Longa 5-point scoring method.Cerebral infarct volume was assessed by 2,3,5-triphenyltetrazolium chloride staining,and apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining.Fis1 and cytosolic cytochrome c levels were assessed by western blot assay.Fis1 mRNA expression was assessed by quantitative reverse transcription-polymerase chain reaction.Mitochondrial ultrastructure was evaluated by transmission electron microscopy.Compared with the sham group,apoptosis,Fis1 protein and mRNA expression and cytosolic cytochrome c levels in the cortical ischemic penumbra and cerebral infarct volume were increased after reperfusion in the other three groups.These changes caused by cerebral ischemia/reperfusion were inhibited in the hypothermia group compared with the normothermia group.These findings show that selective brain hypothermia inhibits Fis1 expression and reduces apoptosis,thereby ameliorating focal cerebral ischemia/reperfusion injury in rats.Experiments were auth 展开更多
关键词 apoptosis Fis1 HYPOTHERMIA ISCHEMIA/REPERFUSION injury mitochondria MITOCHONDRIAL fission MITOCHONDRIAL ultrastructure NEUROPROTECTION SELECTIVE BRAIN HYPOTHERMIA stroke
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tRNA cleavage:a new insight 预览
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作者 Sherif Rashad Kuniyasu Niizuma Teiji Tominaga 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期47-52,共6页
Over the past decades,tRNA was found to be a rich hub of RNA modifications such as 1-methyladenosine and 5-methycytosine modifications and others,holding more than half of all modifications occurring in RNA molecules.... Over the past decades,tRNA was found to be a rich hub of RNA modifications such as 1-methyladenosine and 5-methycytosine modifications and others,holding more than half of all modifications occurring in RNA molecules.Moreover,tRNA was discovered to be a source of various small noncoding RNA species,such as the stress induced angiogenin cleaved tRNA halves(tiRNA)or the miRNA like tRNA derived fragments.tRNA cleavage under stress was fist discovered in bacteria and later was found to be conserved across different species,including mammals.Under cellular stress conditions,tRNA undergoes conformational changes and angiogenin cleaves it into 3′and 5′halves.5′tiRNA halves were shown to repress protein translations.tRNA cleavage is thought of to be a cytoprotective mechanism by which cells evade apoptosis,however some data hints to the opposite;that tiRNA are cytotoxic or at least related to apoptosis initiation.tRNA cleavage also was shown to be affected by tRNA modifications via different enzymes in the cytosol and mitochondria.In this review,we will highlight the biology of tRNA cleavage,show the evidence of it being cytoprotective or a marker of cell death and shed a light on its role in disease models and human diseases as well as possible future directions in this field of RNA research. 展开更多
关键词 ANGIOGENIN apoptosis cell STRESS RNA modification STRESS GRANULES stroke tiRNA translation REPRESSION TRNA TRNA CLEAVAGE
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中医推拿运用于“医养结合”模式防治脑卒中初探 预览
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作者 吕越 晁利芹 《中医学报》 CAS 2019年第9期1997-2000,共4页
目的:探索'医养结合'模式下脑卒中康复方案中医推拿的适用性及适用范围。方法:通过检索中国知网近10年'中医推拿'干预脑卒中的临床研究报道,获得文献后,提取数据并建立数据库,分析中医推拿的介入患者年龄特点、病程特... 目的:探索'医养结合'模式下脑卒中康复方案中医推拿的适用性及适用范围。方法:通过检索中国知网近10年'中医推拿'干预脑卒中的临床研究报道,获得文献后,提取数据并建立数据库,分析中医推拿的介入患者年龄特点、病程特点和适应证,探索其适用性和适用范围。结果:中医推拿干预的脑卒中患者年龄集中在35~80岁、40~80岁、50~80岁;中医推拿介入脑卒中康复患者的最短病程为发病后2周(涉及患者2 399例,60.22%)、最长病程为发病后6个月内(涉及患者1 264例,31.73%);中医推拿干预脑卒中患者适应证主要为脑卒中后运动功能障碍(涉及患者1 171例,28.7%)、脑卒中后肩手综合征(涉及患者338例,8.3%)、脑卒中后痉挛性瘫痪(涉及患者161例,4%)。结论:'医养结合'模式下中医推拿介入脑卒中患者的康复治疗具有重要意义。中医推拿介入到康复治疗方案的时机为发病后2周~6个月,其主要适应证为脑卒中后运动功能障碍、脑卒中后肩手综合征、脑卒中后痉挛性瘫痪。 展开更多
关键词 脑卒中 “医养结合”模式 中医推拿 介入时机 脑卒中后运动功能障碍 脑卒中后肩手综合征 脑卒中后痉挛性瘫痪
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急性缺血性脑卒中及短暂性脑缺血发作患者口服二级预防药物1年复合依从性影响因素分析 预览
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作者 李岩 佟旭 +3 位作者 吴雅坤 郭红梅 裴洪菲 曹亦宾 《山东医药》 CAS 2019年第24期18-22,共5页
目的 观察急性缺血性脑卒中(AIS)及短暂性脑缺血发作(TIA)患者二级预防药物1年复合依从性的影响因素。方法 收集2926例AIS及TIA患者的基线资料及3个月、6个月、1年随访时服药情况。基线资料包括:人口学信息(年龄、性别、民族、医保类型... 目的 观察急性缺血性脑卒中(AIS)及短暂性脑缺血发作(TIA)患者二级预防药物1年复合依从性的影响因素。方法 收集2926例AIS及TIA患者的基线资料及3个月、6个月、1年随访时服药情况。基线资料包括:人口学信息(年龄、性别、民族、医保类型、文化程度、家庭人均月收入、BMI指数)、既往史(吸烟史、饮酒史、高血压史、糖尿病史、脂代谢紊乱史、房颤史、TIA史、AIS史、心肌梗死史,既往服用抗栓药物史、降压药物史、降脂药物史、降糖药物史)、病情概况[发病前改良Rankin量表(mRS)评分,入院时美国国立卫生研究院卒中量表(NIHSS)评分、是否静脉溶栓、住院费用、出院时NIHSS评分、出院时mRS评分、脑卒中类型(AIS、TIA)]、出院带药种类数(仅限于抗栓药、降压药、降脂药、降糖药)。以患者药物复合依从率≥75%为界,将研究对象分为1年复合依从性好组(1257例,占43.0%)、1年复合依从性差组(1669例,占57.0%),比较两组患者的基线资料。将两组基线资料比较中P<0.2的自变量纳入Logistic回归模型,采用向后逐步剔除LR法进行多因素分析。结果 年龄、既往高血压史、既往脂代谢紊乱史、既往服用降压药物史、既往服用降糖药物史、住院费用、脑卒中类型、出院带药种类数等是AIS及TIA患者二级预防药物1年复合依从性的独立影响因素(P均<0.05)。结论 AIS及TIA患者的年龄、既往高血压史、既往脂代谢紊乱史、既往服用降压药物史、既往服用降糖药物史、住院费用、脑卒中类型、出院带药种类数与二级预防药物1年复合依从性有关。 展开更多
关键词 脑卒中 缺血性脑卒中 急性缺血性脑卒中 短暂性脑缺血发作 脑卒中二级预防药物 药物依从性
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中国脑卒中防治:成就、挑战和应对 预览
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作者 巢宝华 刘建民 +7 位作者 王伊龙 杨弋 彭斌 华扬 曹雷 涂文军 闫峰 王陇德 《中国循环杂志》 CSCD 北大核心 2019年第7期625-631,共7页
脑血管病是严重危害国人健康的主要疾病之一,防控工作一直以来颇受重视。我国从上个世纪八九十年代起逐步开展脑血管病防治工作,进入本世纪原国家卫生部专门成立了工作委员会,即现在的国家卫生健康委员会脑卒中防治工程委员会,组织各级... 脑血管病是严重危害国人健康的主要疾病之一,防控工作一直以来颇受重视。我国从上个世纪八九十年代起逐步开展脑血管病防治工作,进入本世纪原国家卫生部专门成立了工作委员会,即现在的国家卫生健康委员会脑卒中防治工程委员会,组织各级卫生行政管理部门、医疗机构、急救单位、疾病预防控制机构和基层卫生医疗单位等开展"防治管康"一体化脑卒中防治体系建设。经过多年努力,防治工作取得了一定进展,脑卒中人口标化死亡率呈现下降趋势。虽然如此,脑卒中仍然是我国成人致死和致残的首位原因,脑卒中防治依旧面临巨大挑战。未来,国家将持续加强人群健康宣教和筛查干预力度;大力推动脑卒中中心建设,完善区域脑卒中防治体系建设;以血压管控和脑卒中防治适宜技术推广为抓手,积极开展"减少百万新发残疾工程"工作,全面推动我国脑卒中防治工作的提档升级,为国民健康保驾护航。 展开更多
关键词 脑卒中 防治工程 脑卒中防治体系 中国
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中风病因病机新说 预览
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作者 秦瑜玲 舒杨 +1 位作者 卢岩 孙英霞 《河南中医》 2019年第9期1309-1313,共5页
对于中风的病因病机,唐宋以前的医家大都持外风论,认为中风的发生是在脏腑失和,气血不足等内虚的基础上受到外邪侵袭所致;金元时期,百家争鸣,内风学说逐渐盛行,元代的王履首次明确提出真中风与类中风的区别;到了明清时期,医家对内风论... 对于中风的病因病机,唐宋以前的医家大都持外风论,认为中风的发生是在脏腑失和,气血不足等内虚的基础上受到外邪侵袭所致;金元时期,百家争鸣,内风学说逐渐盛行,元代的王履首次明确提出真中风与类中风的区别;到了明清时期,医家对内风论推崇备至,逐渐接受了王履提出的"类中风"观点,尤以张景岳为代表,他甚至提出"非风论",认为内伤积损是中风的病因;晚清时期,内风论逐渐深化,同时,西学东渐,血气冲脑的中西医结合理论被提出;现代医家也提出了种种新的理论学说。每种学说均有其最佳适用时期及人群,但又不完全对立,而是不断补充,相互完善。临床对于中风的诊治,理清各个理论之间的区别与联系,合理把握其适用范围,方能融会贯通,把各家学说的指导价值最大化。 展开更多
关键词 中风 病因病机 内风 外风 真中风 类中风
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拉莫三嗪联合丙戊酸钠预防卒中后痫性发作的临床有效率分析 预览
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作者 王国卿 王军 沈象鹏 《系统医学》 2019年第9期75-77,共3页
目的探讨拉莫三嗪联合丙戊酸钠预防脑卒中继发性癫痫的临床有效率。方法研究对象为2012年3月-2016年4月间符合标准的卒中后痫性发作的高危患者,随机分为两组,即为观察组与不用预防药物(对照组);随访观察2年左右时间,研究对早发痫性发作... 目的探讨拉莫三嗪联合丙戊酸钠预防脑卒中继发性癫痫的临床有效率。方法研究对象为2012年3月-2016年4月间符合标准的卒中后痫性发作的高危患者,随机分为两组,即为观察组与不用预防药物(对照组);随访观察2年左右时间,研究对早发痫性发作、迟发痫性发作及癫痫预防作用。结果①两组在基线对比中差异无统计学意义(P<0.05)。②早发型痫性发作及早发癫痫:发病率(χ^2=16.87,P=0.01)、发作时间持续(χ^2=68.51,P=0.01)比较,观察组明显低于对照组,差异有统计学意义;③迟发型痫性发作及癫痫:发病率(χ^2=0.03,P=0.87)、发作时间持续(χ^2=0.14,P=0.74)比较观察组与对照组没有统计学差异;④首次痫性发作时间:观察组卒中后首次癫痫发作间隔时间长于对照组,差异有统计学意义(χ^2=94.12,P=0.01)。结论卒中后痫性发作的高危人群早期、短期应用拉莫三嗪联合丙戊酸钠治疗早发性痫性发作、癫痫较高的预防作用;但对迟发痫性发作及癫痫无预防作用。 展开更多
关键词 拉莫三嗪 丙戊酸钠 脑卒中 卒中后痫性发作 卒中后癫痫
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