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Characteristics of Persistent or Recurrent Differentiated Thyroid Cancer 预览
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作者 Annelie Kérékou Hodé Siham El Aziz +2 位作者 Alihonou Dédjan Asma Chadli Ahmed Farouqi 《内分泌与新陈代谢疾病期刊(英文)》 2020年第1期1-5,共5页
Introduction: The differentiated thyroid cancer has generally an excellent prognosis after the treatment. The aim of this study is to describe the characteristics of persistent or recurrent differentiated thyroid canc... Introduction: The differentiated thyroid cancer has generally an excellent prognosis after the treatment. The aim of this study is to describe the characteristics of persistent or recurrent differentiated thyroid cancers. Patients/ Methods: It is about a descriptive and retrospective study conducted from 392 patients followed for differentiated thyroid cancer. The data concerning the persistent or recurrent differentiated thyroid cancer have been collected from 1986 to 2015 in endocrinology service in Ibn Rochd CHU. Results: In total, twenty-four patients have shown the relapse or the persistency of their tumor, corresponding to the prevalence of 6.12 percent. The papillary carcinoma was dominant in 79 percent of cases and the follicular carcinoma in 21 percent of cases. The metastases were cerebral (two cases), lung (3 cases), bones (3 cases, Figure 1), and lymph nodes (9 cases). In our series, eighteen cases of persistent differentiated thyroid cancer have been found against six cases of recurrent differentiated thyroid cancer. Two cases of death at least three years of followed in our series and concerned the two cases of cerebral metastasis. Conclusion: The persistent or recurrent differentiated thyroid cancer rate is low in our series. The discovery of the relapse t is late. 展开更多
关键词 DIFFERENTIATED THYROID CANCER METASTASIS
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Extracranial Metastasis of an Anaplastic Ependymoma, RELA Fusion-Positive: A Rare Occurrence 预览
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作者 Christine Milena Sayore Nabil Adio Mousse +3 位作者 Mohammed Yassaad Oudrhiri Nadia Cherradi Adyl Melhaoui Abdessamad El Ouahabi 《现代神经外科学进展(英文)》 2020年第1期9-18,共10页
Primary intracranial ependymomas originate from ependymal cells. They may migrate mainly in the spinal cord but rarely metastasize outside the central nervous system. Metastases outside the central nervous system are ... Primary intracranial ependymomas originate from ependymal cells. They may migrate mainly in the spinal cord but rarely metastasize outside the central nervous system. Metastases outside the central nervous system are rare. Metastatic diffusion from the central nervous system is low due to the unique interaction of the brain and the tumor with the blood-brain barrier. Nevertheless, three main hypotheses have been mentioned in the literature, the tumor growth, the surgical manipulation (which may be considered to be the case in our patient), and the aggressiveness of the tumor according to the Ki67 index. We report the case of a 16-year-old female, who underwent complete surgical removal of a left occipital 2007 WHO grade II ependymoma. 3 years later, the patient presented multiple cervical and occipital indurated masses. MRI showed a left hemispheric meningeal infiltration, with multiple nodules located on the neck, occiput and mastoid. Histopathological study of a left temporal surgical biopsy and resection of an occipital subcutaneous nodule turned to be metastases of an anaplastic ependymoma. The ependymoma considered as a benign tumor could very quickly turn into malignancy by its metastatic potential. Early diagnosis and longer follow-up of patients would be recommended for a rapid management. 展开更多
关键词 ANAPLASTIC EPENDYMOMA EXTRACRANIAL Metastasis Extraneural RELA FUSION
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Isolated vaginal metastasis from stage Ⅰ colon cancer: A case report 预览
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作者 Soon Keun Kwon Chang Sik Yu +8 位作者 Shin-Wha Lee Jihun Kim Inho Song Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim 《世界临床病例杂志》 2020年第3期527-534,共8页
BACKGROUND Distant metastasis occasionally occurs in patients who have been diagnosed with colorectal cancer(CRC), but it occurs in a few patients with stage I CRC. The vagina as a metastasis site has also been report... BACKGROUND Distant metastasis occasionally occurs in patients who have been diagnosed with colorectal cancer(CRC), but it occurs in a few patients with stage I CRC. The vagina as a metastasis site has also been reported, albeit rarely. Most reported cases of vaginal metastasis(VM) report their origin from advanced CRC. We encountered a patient who was diagnosed with isolated VM originating from stage I colon cancer(T2N0) and herein present the case of this patient.CASE SUMMARY A 63-year-old woman visited the outpatient clinic because of a positive result from a stool occult blood test. She underwent laparoscopic anterior resection and was pathologically diagnosed with stage I(T2N0) sigmoid colon cancer. Neither lymphovascular invasion nor perineural invasion was observed. Ten months following the surgery, isolated vaginal metastases were detected on gynecologic examination. The examination was performed due to vaginal spotting. A transvaginal wide excision was performed, and no other adjuvant treatment was provided after discussion with a multidisciplinary team and the patient.Subsequently, a new VM was discovered after 33 mo. An additional transvaginal excision was performed. To date, there has been no evidence of further disease progression. From the time of diagnosis of VM, the patient’s overall survival has been 54 mo.CONCLUSION VM can occur as a result of early-stage colorectal cancer. Surgeons should consider the possibility of VM following complaints of gynecologic symptoms following surgery. 展开更多
关键词 Colorectal cancer Stage I Vaginal metastasis Isolated metastasis Case report
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Abdominal metastases of primary extremity soft tissue sarcoma:A systematic review 预览
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作者 Maria Anna Smolle Andreas Leithner Gerwin Alexander Bernhardt 《世界临床肿瘤学杂志(英文版)》 2020年第2期74-82,共9页
BACKGROUND Despite the fact that about one third of patients with primary localized extremity soft tissue sarcoma(e STS)will develop metastatic disease,abdominal metastases(AM)and retroperitoneal metastases(RM)constit... BACKGROUND Despite the fact that about one third of patients with primary localized extremity soft tissue sarcoma(e STS)will develop metastatic disease,abdominal metastases(AM)and retroperitoneal metastases(RM)constitute rare events.There is no clear consensus on how to achieve follow-up on patients with primary localized e STS following curative resection,especially regarding the surveillance of potential AM/RM.AIM To systematically analyse incidence,diagnosis,treatment and outcome of AM/RM in e STS patients.METHODS In this systematic review,899 studies available in Pub Med and published between 2000 and 2018 were screened,identifying 17 original articles focused on AM or RM in e STS.Article selection was based on the PRISMA guidelines,using the search terms(abdominal metastasis AND soft tissue sarcoma)and(soft tissue sarcoma metastasis abdomen).All studies published between January 1,2000 and December 31,2018 were screened.Further articles were identified by crosssearching article references,with the final search date being February 18,2019.Due to limited data and the different reporting techniques used,the present review focused on descriptive analysis of the included studies.RESULTS Of the 17 studies included,six original articles reported on incidence±diagnosis,therapy and outcome in AM and RM,whilst three original and eight case reports focused on diagnostic pathway,therapeutic procedures or outcomes without allowing conclusions regarding incidence of AM and RM.According to the former six studies,incidence of AM ranged from 0.9%-5.6%in patients with miscellaneous histological subtypes,and up to 12.1%in patients with myxoid liposarcoma.The most common histological subtypes that developed AM or RM were(myxoid)liposarcoma and leiomyosarcoma,but also rare subtypes such asepithelioid sarcoma,myxofibrosarcoma,synovial sarcoma,and malignant peripheral nerve sheath tumour had been reported to develop AM/RM.Surgery for AM/RM was performed in five of eight case-reports(62.5%)and in 20.8%-100.0%of original articles.I 展开更多
关键词 Extremity soft tissue sarcoma Abdominal metastasis Retroperitoneal metastasis Diagnosis Treatment OUTCOME
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mortalin蛋白在宫颈鳞癌中的表达及其对肿瘤转移能力的影响 预览
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作者 王馨悦 李楠 +2 位作者 董兵 杨洋 林贞花 《中国病理生理杂志》 CAS CSCD 北大核心 2020年第1期146-151,共6页
目的:探讨寿命蛋白(mortalin)在子宫颈鳞癌组织中过表达的临床病理学意义及其与子宫颈鳞癌转移之间的关系。方法:应用免疫荧光染色在人子宫颈鳞癌SiHa细胞系中检测mortalin的定位情况,并采用免疫组化EnVision法检测mortalin在59例正常... 目的:探讨寿命蛋白(mortalin)在子宫颈鳞癌组织中过表达的临床病理学意义及其与子宫颈鳞癌转移之间的关系。方法:应用免疫荧光染色在人子宫颈鳞癌SiHa细胞系中检测mortalin的定位情况,并采用免疫组化EnVision法检测mortalin在59例正常宫颈上皮组织和93例子宫颈鳞癌组织中的表达,分析mortalin表达与子宫颈鳞癌患者临床病理特征之间的关系;通过MTT实验筛选mortalin抑制剂MKT-077作用浓度及时间后,抑制SiHa细胞中mortalin表达并进行细胞划痕及迁移实验,Western blot检测参与上皮-间充质转化(EMT)相关蛋白的表达。结果:免疫荧光结果显示,mortalin定位于子宫颈鳞癌SiHa细胞质中。免疫组化结果表明,mortalin在子宫颈鳞癌组织中表达的阳性率和强阳性率分别为89.2%(83/93)和62.4%(58/93),显著高于正常宫颈上皮组织(23.7%和5.1%,P<0.01);mortalin表达水平与子宫颈鳞癌患者肿瘤组织学分级、临床分期及淋巴结转移密切相关(P<0.05)。通过MKT-077抑制SiHa细胞中mortalin的表达后,细胞划痕及迁移实验结果显示SiHa细胞的迁移能力下调,Western blot结果表明E-cadherin的表达明显上调,vimentin及Snail的表达明显下调(P<0.05)。结论:mortalin的表达水平与子宫颈鳞癌的发生发展及转移密切相关,该蛋白有望成为子宫颈癌患者预后评估的分子指标。 展开更多
关键词 寿命蛋白 子宫颈鳞状细胞癌 预后 转移
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TRPM7的表达水平与肺癌发生发展的关系
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作者 陈美姿 曾龙 +1 位作者 段歆彤 胡洪波 《基因组学与应用生物学》 CAS CSCD 北大核心 2020年第1期349-356,共8页
为了解TRPM7在肺癌中的表达及其与肺癌进展的关系,本研究检测了TRPM7在非小细胞肺癌患者肺癌组织样本和相邻正常肺泡组织样本中的表达,以及TRPM7在人肺腺癌A549细胞系和人支气管上皮细胞系16HBE中的表达。通过转染shRNA敲低肺癌细胞中的... 为了解TRPM7在肺癌中的表达及其与肺癌进展的关系,本研究检测了TRPM7在非小细胞肺癌患者肺癌组织样本和相邻正常肺泡组织样本中的表达,以及TRPM7在人肺腺癌A549细胞系和人支气管上皮细胞系16HBE中的表达。通过转染shRNA敲低肺癌细胞中的TRPM7,并应用TRPM7拮抗剂Waixenicin A处理细胞。免疫组化染色和Western blotting分析显示,与正常肺泡组织样本中的TRPM7表达相比,TRPM7在肺癌样本中显著高表达。TRPM7的表达水平与癌症分期有关,分期越高,TRPM7的表达水平越高。TRPM7在A549细胞中的表达强度显著高于16HBE细胞。细胞集落形成测定结果显示,沉默TRPM7会显著抑制细胞集落形成的能力。SRB细胞活力测定显示,沉默TRPM7会显著抑制细胞活力。沉默TRPM7显著降低了肺癌细胞的迁移(-68.94%)和侵袭(-68.84%)能力。沉默TRPM7显著抑制了热休克蛋白90α(HSP90α)、尿激酶型纤溶酶原激活剂(uPA)和基质金属蛋白酶2 (MMP2)的表达。Waixenicin A显著抑制了肺癌细胞的活力及Hsp90α/uPA/MMP2信号分子的表达。另外,Waixenicin A显著降低了肺癌细胞的迁移(-65.35%)和侵袭(-71.85%)能力。本研究表明,TRPM7的异常表达通过激活Hsp90α/uPA/MMP2信号通路来提高人肺癌细胞的活力和转移能力。研究结果表明,靶向TRPM7的抑制剂可能是治疗肺癌的有效药物。 展开更多
关键词 TRPM7 肺癌 细胞活力 转移 Waixenicin A
Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies 预览
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作者 Peng-Ju Chen Lin Wang +2 位作者 Yi-Fan Peng Nan Chen Ai-Wen Wu 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2020年第3期323-331,共9页
BACKGROUND Malignant bowel obstruction(MBO)is a common event for end-stage gastrointestinal cancer patients.Previous studies had demonstrated manifestations and clinical management of MBO with mixed malignancies.There... BACKGROUND Malignant bowel obstruction(MBO)is a common event for end-stage gastrointestinal cancer patients.Previous studies had demonstrated manifestations and clinical management of MBO with mixed malignancies.There still lack reports of the surgical treatment of MBO.AIM To analyze the short-term outcomes and prognosis of palliative surgery for MBO caused by gastrointestinal cancer.METHODS A retrospective chart review of 61 patients received palliative surgery between January 2016 to October 2018 was performed,of which 31 patients underwent massive debulking surgery(MDS)and 30 underwent ostomy/by-pass surgery(OBS).The 60-d symptom palliation rate,30-d morbidity and mortality,and overall survival rates were compared between the two groups.RESULTS The overall symptom palliation rate was 75.4%(46/61);patients in the MDS group had significantly higher symptom palliation rate than OBS group(90%vs 61.2%,P=0.016).Patients with colorectal cancer who were in the MDS group showed significantly higher symptom improvement rates compared to the OBS group(overall,76.4%;MDS,61.5%;OBS,92%;P=0.019).However,patients with gastric cancer did not show a significant difference in symptom palliation rate between the MDS and OBS groups(OBS,60%;MDS,80%;P=1.0).The median survival time in the MDS group was significantly longer than in the OBS group(10.9 mo vs 5.3 mo,P=0.05).CONCLUSION For patients with MBO caused by peritoneal metastatic colorectal cancer,MDS can improve symptom palliation rates and prolong survival,without increasing mortality and morbidity rates. 展开更多
关键词 Gastrointestinal neoplasms Malignant bowel obstruction METASTASIS Palliative surgery PROGNOSIS Quality of life
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间充质干细胞对乳腺癌细胞的影响 预览
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作者 张耀天 韩翰 《沈阳医学院学报》 2020年第2期183-186,共4页
乳腺癌是威胁女性健康的常见肿瘤之一,近年来发病率已居全球女性恶性肿瘤首位。间充质干细胞(mesenchymal stem cells,MSCs)作为参与构成肿瘤微环境的重要组分,通过与乳腺癌细胞之间的相互作用对乳腺癌的进展产生影响。本文对MSCs在乳... 乳腺癌是威胁女性健康的常见肿瘤之一,近年来发病率已居全球女性恶性肿瘤首位。间充质干细胞(mesenchymal stem cells,MSCs)作为参与构成肿瘤微环境的重要组分,通过与乳腺癌细胞之间的相互作用对乳腺癌的进展产生影响。本文对MSCs在乳腺癌的侵袭和转移过程中发挥的作用进行综述。 展开更多
关键词 间充质干细胞 乳腺癌 侵袭 转移
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微小RNA-92a-3p靶向PTEN调控胰腺癌细胞增殖和转移 预览
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作者 刘宇 胡庆 +2 位作者 敖晶晶 李红玲 李美梁 《中南大学学报:医学版》 CAS CSCD 北大核心 2020年第3期280-289,共10页
目的:探讨微小RNA-92a-3p(microRNA-92a-3p,miR-92a-3p)靶向第10号染色体缺失的磷酸酶及张力蛋白同源基因(phosphatase and tension homolog deleted on chromosome ten,PTEN)调控胰腺癌细胞增殖和转移的作用机制。方法:采用Real-time ... 目的:探讨微小RNA-92a-3p(microRNA-92a-3p,miR-92a-3p)靶向第10号染色体缺失的磷酸酶及张力蛋白同源基因(phosphatase and tension homolog deleted on chromosome ten,PTEN)调控胰腺癌细胞增殖和转移的作用机制。方法:采用Real-time PCR检测人正常胰腺导管上皮细胞株(HPDE6-C7)与胰腺癌细胞株(Panc-1,BxPC-3,AsPC-1,MIA Paca-2,Capan-2)中的miR-92a-3p表达;同时,采用蛋白质印迹法检测上述细胞中PTEN的表达。选取胰腺癌细胞株BxPC-3和Panc-1的细胞进行实验,分为转染对照模拟物组(NC mimics组)、miR-92a-3p模拟物组(miR-92a-3p mimics组)、对照拮抗剂组(NC inhibitor组)、miR-92a-3p拮抗剂(miR-92a-3p inhibitor组),采用细胞计数试剂盒-8(cell counting kit-8,CCK-8)检测细胞增殖,Transwell小室检测细胞转移能力,蛋白质印迹法检测PTEN蛋白表达水平。将野生型PTEN的3’-非编码区(untranslated regions,UTR)(wt-PTEN 3’UTR)或突变体PTEN的3’-UTR(mutPTEN 3’UTR)分别与NC mimics,miR-92a-3p mimics,NC inhibitor,miR-92a-3p inhibitor共转染293T细胞,采用双萤光素酶报告实验检测miR-92a-3p与PTEN的靶向结合关系。在BxPC-3细胞的回复实验中,实验又分NC inhibitor+siNC组、miR-92a-3p inhibitor+si-NC组、NC inhibitor+si-PTEN组和miR-92a-3p inhibitor+si-PTEN组;在Panc-1细胞的回复实验中,实验又分为NC mimics+NC组、miR-92a-3p mimics+NC组、NC mimics+PTEN组和miR-92a-3p mimics+PTEN组,再分别采用CCK-8检测细胞增殖,Transwell小室检测细胞转移能力,蛋白质印迹法检测PTEN蛋白的表达。结果:与HPDE6-C7细胞相比,miR-92a-3p在胰腺癌细胞株中均呈高表达(均P<0.01),PTEN在胰腺癌细胞株中均呈低表达(均P<0.05)。与NC mimics组相比,miR-92a-3p mimics组BxPC-3和Panc-1细胞活力均升高(均P<0.01);与NC inhibitor组相比,miR-92a-3p inhibitor组BxPC-3和Panc-1细胞活力均降低(均P<0.01)。与NC mimics组相比,miR-92a-3p mimics组穿过微孔的BxPC-3和Panc-1细胞数均增多(均P<0.01);与NC inhibitor� 展开更多
关键词 胰腺癌 转移 增殖 微小RNA-92a-3p 10号染色体缺失的磷酸酶及张力蛋白同源物
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Cryoablation for liver metastasis from solid pseudopapillary tumor of the pancreas: A case report 预览
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作者 Yang-Yang Ma Ji-Bing Chen +2 位作者 Juan-Juan Shi Li-Zhi Niu Ke-Chen Xu 《世界临床病例杂志》 2020年第2期398-403,共6页
BACKGROUND Solid pseudopapillary tumor(SPT) of the pancreas is a rare pancreatic tumor and 10% to 15% of cases are associated with metastasis. Cryoablation is a new method that can induce tumor necrosis, and treatment... BACKGROUND Solid pseudopapillary tumor(SPT) of the pancreas is a rare pancreatic tumor and 10% to 15% of cases are associated with metastasis. Cryoablation is a new method that can induce tumor necrosis, and treatment of tumors by cryoablation can cause anti-tumor immune responses.CASE SUMMARY A 16-year-old woman with SPT of the pancreas developed liver metastases 5.3 years after complete resection of the primary pancreatic tumor. She was admitted with chief complaints of abdominal pain in the upper abdomen and a weight loss of approximately 5 kg over 4 mo. Carbohydrate antigen(CA) 125,carcinoembryonic antigen, and CA 199 were normal. An abdominal computed tomography scan found multiple nodules in the right lobe of the liver that measured approximately 13.5 cm × 10.8 cm × 21.4 cm. Immunohistochemical staining results showed that CD10 and CD56 were positive, and the patient was diagnosed with SPT of the pancreas with liver metastasis. The patient underwent percutaneous cryoablation and interventional embolization. During the 5-year follow-up, the patient remained disease-free after cryoablation, with relatively normal immune function.CONCLUSION Herein, we for the first time report the treatment of liver metastasis from SPT of the pancreas using cryoablation plus interventional embolization, which could be a promising alternative therapy for pancreatic SPT liver metastasis. 展开更多
关键词 Solid pseudopapillary tumor PANCREAS Liver metastasis CRYOABLATION Interventional embolization Case report
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益气养阴化瘀方治疗肺癌术后复发和转移临床研究
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作者 李华 郭丽 +2 位作者 憨镔 李蕾 黄雪青 《新中医》 CAS 2020年第4期118-121,共4页
目的:观察益气养阴化瘀方治疗对肺癌术后患者复发和转移的影响。方法:将接受手术治疗的非小细胞肺癌患者88例随机分为2组,对照组44例术后行常规GP方案治疗,观察组44例在对照组的基础上加服益气养阴化瘀方治疗8周,观察患者治疗后复发转... 目的:观察益气养阴化瘀方治疗对肺癌术后患者复发和转移的影响。方法:将接受手术治疗的非小细胞肺癌患者88例随机分为2组,对照组44例术后行常规GP方案治疗,观察组44例在对照组的基础上加服益气养阴化瘀方治疗8周,观察患者治疗后复发转移情况,血清肿瘤标志物[血管内皮生长因子(VEGF)、癌胚抗原(CEA)、糖链抗原CA199、CA125、CA50]含量及免疫功能[T淋巴细胞(CD8^+、CD4^+、CD3^+、CD4^+/CD8^+)和自然杀伤细胞(NK)]改变情况。结果:随访12个月,观察组患者复复发2例(4.55%),转移10例(22.73%);对照组复发3例(6.82%),转移12例(27.27%);观察组复发率、转移率均低于对照组,但差异无统计学意义(P>0.05)。治疗后及随访12个月,观察组血清VEGF、CEA、CA199、CA50含量均较治疗前显著降低(P<0.05)。治疗后,对照组血清VEGF、CEA、CA199、CA50含量均较治疗前显著降低(P<0.05);随访12个月,对照组血清VEGF含量降低,CA125、CA50含量升高(P<0.05)。随访12个月,观察组患者血清VEGF、CEA、CA199、CA125及CA50含量均明显低于对照组(P<0.05)。随访12个月,观察组患者CD8^+、CD4^+、CD3^+含量均较治疗前及对照组同时间点显著升高(P<0.05)。治疗后,对照组患者CD3^+、CD4^+/CD8^+比值均较治疗前显著降低(P<0.05)。治疗后,观察组CD3^+、CD4^+/CD8^+比值均较对照组升高(P<0.05)。2组治疗前后NK值变化不显著(P>0.05)。结论:在肺癌术后GP方案治疗的基础上,加用益气养阴化瘀方可降低患者复发转移率、血清肿瘤标志物含量,提高患者机体免疫功能。 展开更多
关键词 肺癌 手术 复发 转移 GP方案 益气养阴化瘀方
胃肠道间质瘤术后复发转移的危险因素分析
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作者 孙毕胜 张乾世 +2 位作者 刘敦波 冯震 任双义 《大连医科大学学报》 CAS 2020年第1期51-55,共5页
目的分析胃肠道间质瘤术后复发转移患者的临床特点及危险因素。方法收集大连医科大学附属第二医院2010—2016年诊治的55例胃肠间质瘤患者的临床资料。总结术后用药、随访及复发转移等情况,并使用卡方检验对年龄、性别、肿瘤直径、核分... 目的分析胃肠道间质瘤术后复发转移患者的临床特点及危险因素。方法收集大连医科大学附属第二医院2010—2016年诊治的55例胃肠间质瘤患者的临床资料。总结术后用药、随访及复发转移等情况,并使用卡方检验对年龄、性别、肿瘤直径、核分裂像、肿瘤原发部位、Ki-67指数、肿瘤浸润深度、出血坏死等因素与患者术后复发转移情况进行单因素分析,从中筛选有意义的因素使用二元Logistic回归进行多因素分析,并使用卡方检验研究Ki-67指数与临床病理因素的关系。结果胃肠道间质瘤术后未行标准剂量辅助治疗或未规律的行标准剂量辅助治疗的患者复发转移率明显高于术后行规律的标准剂量辅助治疗者。肿瘤直径、核分裂像、肿瘤原发部位、Ki-67指数、肿瘤浸润深度和出血坏死等因素与胃肠道间质瘤术后复发转移相关(P<0.05)。多因素分析发现Ki-67指数是影响患者术后复发转移的独立危险因素(P<0.05)。Ki-67指数与肿瘤部位、直径、核分裂像数目、危险度分级等因素有关(P<0.05)。结论胃肠道间质瘤术后需行规律的标准剂量辅助治疗。影响胃肠道间质瘤术后复发转移的危险因素为肿瘤直径、核分裂像、肿瘤原发部位、Ki-67指数、肿瘤浸润深度和出血坏死;Ki-67指数与胃肠道间质瘤的危险度分级有关,可能用于指导胃肠道间质瘤术后标准剂量的辅助治疗。 展开更多
关键词 胃肠道间质瘤 复发 转移 危险因素
ERBB3在甲状腺癌患者中的表达及其意义 预览
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作者 王岩 杨龙艳 +3 位作者 孙荣欣 张媛媛 付颖 赵冬 《中国医药导报》 CAS 2020年第5期18-22,共5页
目的探讨ERBB3在甲状腺癌发生发展过程中的功能和作用。方法收集2017年12月~2018年12月北京潞河医院内分泌科甲状腺癌患者4例与甲状腺结节患者6例的细针穿刺组织进行RNA-seq检测,并分析ERBB3水平;利用TCGA甲状腺癌数据库与GEO甲状腺癌... 目的探讨ERBB3在甲状腺癌发生发展过程中的功能和作用。方法收集2017年12月~2018年12月北京潞河医院内分泌科甲状腺癌患者4例与甲状腺结节患者6例的细针穿刺组织进行RNA-seq检测,并分析ERBB3水平;利用TCGA甲状腺癌数据库与GEO甲状腺癌数据库,分析比较癌与癌旁,T、N分期,复发患者中ERBB3的水平;采用基因富集分析GSEA分析ERBB3水平与EGFR、PI3K、ERK1/2信号通路的关系,以及肿瘤增殖、转移的关系。结果与良性甲状腺结节比较,ERBB3 mRNA在甲状腺癌中表达量升高(P<0.001)。与癌旁比较,ERBB3 mRNA在甲状腺癌组织中升高(TCGA来源:P<0.0001;GEO来源:P<0.0001)。在甲状腺癌患者中,EGFR、PI3K、ERK1/2基因集显著富集于ERBB3高表达患者中。随着T分期的增长,ERBB3水平逐渐增加(P<0.0001);与增殖相关的基因集显著富集于ERBB3高表达患者中。与N0组比较,N1期患者ERBB3水平显著增加(P<0.0001)。与转移相关的基因集显著富集于ERBB3高表达患者中。甲状腺癌复发患者ERBB3的水平升高(P=0.0124)。结论ERBB3可能参与了甲状腺癌的增殖、转移及复发,有望成为甲状腺癌治疗的新靶点。 展开更多
关键词 ERBB3 甲状腺癌 增殖 转移 复发
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18F-FDG PET/CT显像联合CA125及HE4在上皮性卵巢癌患者术后复发/转移诊断中的价值 预览
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作者 西尔艾力·吾门尔 赵艳萍 《分子影像学杂志》 2020年第1期70-75,共6页
目的探讨18F-脱氧葡萄糖PET/CT显像联合血清糖类抗原125及人附睾蛋白4检测在上皮性卵巢癌患者术后复发/转移中的诊断价值。方法回顾性分析2018年7月~2019年9月在我院核医学科行18F-FDG PET/CT显像并显像前已行血清CA125及HE4值检测的65... 目的探讨18F-脱氧葡萄糖PET/CT显像联合血清糖类抗原125及人附睾蛋白4检测在上皮性卵巢癌患者术后复发/转移中的诊断价值。方法回顾性分析2018年7月~2019年9月在我院核医学科行18F-FDG PET/CT显像并显像前已行血清CA125及HE4值检测的65例上皮性卵巢癌患者作为研究对象。分18F-FDG PET/CT显像诊断组和18F-FDG PET/CT+CA125+HE4诊断组进行诊断并依据随访标准进行随访,各组诊断结果与随访结果进行比较。结果 18F-FDG PET/CT显像在评估上皮性卵巢癌患者术后复发/转移的灵敏度、特异度、阳性预测值、阴性预测值、一致率分别为96.22%、66.7%、92.73%、80.0%、90.77%。18FFDG PET/CT+CA125+HE4评估上皮性卵巢癌患者术后复发/转移的灵敏度、特异度、阳性预测值、阴性预测值、一致率分别为98.1%、66.7%、92.9%、88.9%、92.3%。复发/转移组CA125及HE4受试者工作特征曲线得知临界值分别为20.65 U/m L、45.5pmol/L。18F-FDG PET/CT+CA125临界值+HE4临界值评估上皮性卵巢癌患者术后复发/转移的灵敏度、特异度、阳性预测值、阴性预测值、一致率分别为98.1%、75.0%、94.6%、90.0%、93.9%。结论 18F-FDG PET/CT显像在评估上皮性卵巢癌患者术后复发/转移上有优势。18F-FDG PET/CT+CA125+HE4检测在评估上皮性卵巢癌患者术后复发/转移上有较高的诊断价值,三者联合检测优于单独检测及两者联合检测。18F-FDG PET/CT+CA125临界值+HE4临界值检测在评估上皮性卵巢癌患者术后复发/转移上有更高的诊断价值。在临床随访过程中发现血清CA125≥20.65 U/m L,血清HE4≥45.5 pmol/L,并持续增加时应保持警惕,并选择18F-FDG PET/CT显像来提高上皮性卵巢癌复发/转移检出率,早期发现复发/转移病灶。。 展开更多
关键词 卵巢癌 PET/CT显像 CA125 HE4 复发 转移
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结直肠癌转移的中医理论构想
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作者 林怡 陶丽 《上海中医药杂志》 2020年第2期6-9,共4页
结直肠癌患者死亡的主要原因是侵袭转移,因此控制其转移对延长晚期结直肠癌患者的生存期具有重要意义。从病因病机出发,结合古典医籍、各家学说、临床与基础实验文献,提出结直肠癌转移的中医理论构想:正气亏虚(尤其是脾虚)是内在根本,... 结直肠癌患者死亡的主要原因是侵袭转移,因此控制其转移对延长晚期结直肠癌患者的生存期具有重要意义。从病因病机出发,结合古典医籍、各家学说、临床与基础实验文献,提出结直肠癌转移的中医理论构想:正气亏虚(尤其是脾虚)是内在根本,癌毒内结(痰、瘀、毒、潜伏下来的致病因子)是必要条件,经络传注是主要途径,诱因则可成为导火索,最终造成癌毒在经络之间、脏腑之间、经络脏腑之间的传变。认为防治结直肠癌侵袭转移当以健脾为主,结合各种祛邪手段(化痰、软坚、解毒、化瘀等),修复受损之络脉。 展开更多
关键词 结直肠癌 转移 病因病机 正气亏虚 癌毒内结 经络传注 中医药疗法
Clinical characteristics, treatments, and prognosis of patients with multiple primary carcinoma of head and neck
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作者 Kun Liu Xin-Xin Zhang +6 位作者 Nan-Xiang Chen Wen-Ming Wu Jia-Ling Wang De-Liang Huang Jian-Dong Zhao Shi-Ming Yang Lin Ma 《中华医学杂志:英文版》 SCIE CAS CSCD 2020年第3期377-378,共2页
To the Editor: Multiple primary carcinoma (MPC) or secondary primary carcinoma refers to two or more malignant tumors occurring in the same organ or different organs of a patient. MPC is classified into synchronous MP... To the Editor: Multiple primary carcinoma (MPC) or secondary primary carcinoma refers to two or more malignant tumors occurring in the same organ or different organs of a patient. MPC is classified into synchronous MPC (time between diagnoses ≤6 months) and metachronous MPC (time between diagnoses >6 months).[1] Clinically, MPC was easily misdiagnosed as the recurrence and metastasis of malignant tumor. In head and neck MPC patients, the correct diagnosis and active treatments are important. 展开更多
关键词 ORGANS DIAGNOSIS treatment METASTASIS HEAD
影响乳腺癌改良根治术患者术后复发转移的有序logistic分析 预览
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作者 张泽玉 贾婷婷 +1 位作者 邱体红 罗杰 《实用癌症杂志》 2020年第2期263-266,共4页
目的探讨影响乳腺癌患者改良根治术后转移复发的危险因素。方法回顾性分析130例乳腺癌患者临床资料,根据5年内复发转移情况将其分为危险组(n=42)与对照组(n=88)。比较2组基线资料、治疗措施、实验室检测指标等项目内各因素差异,针对单... 目的探讨影响乳腺癌患者改良根治术后转移复发的危险因素。方法回顾性分析130例乳腺癌患者临床资料,根据5年内复发转移情况将其分为危险组(n=42)与对照组(n=88)。比较2组基线资料、治疗措施、实验室检测指标等项目内各因素差异,针对单因素比较存在统计学意义项目予以有序logistic多因素回归分析。结果2组年龄、母乳喂养时间、绝经、术后辅助化疗及人表皮生长因子受体2(HER2)表达情况比较,差异均无统计学意义(P均>0.05);而肿瘤最大直径较大、未接受术前新辅助化疗、淋巴结转移阳性及雌激素受体(ER)/孕激素受体(PR)双阴性均是导致乳腺癌改良根治术后5年内复发转移的独立危险因素(P均<0.05)。结论乳腺癌改良根治术后复发转移与肿瘤直径、新辅助化疗、淋巴结转移及ER/PR表达情况均存在密切联系,临床需据此采取针对性干预措施加以防范。 展开更多
关键词 乳腺癌 改良根治术 复发 转移 LOGISTIC分析
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乳腺癌前哨淋巴结转移的相关因素分析及病理学研究 预览
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作者 张卫 黄彬 沈丽 《实用癌症杂志》 2020年第2期267-269,共3页
目的探究乳腺癌前哨淋巴结转移的相关因素。方法回顾性分析162例前哨淋巴结活检技术的乳腺癌患者的临床资料,对乳腺癌临床病理指标与前哨淋巴结转移之间的关系进行因素分析。结果前哨淋巴结阳性共83例,前哨淋巴结阴性共79例。2组间的年... 目的探究乳腺癌前哨淋巴结转移的相关因素。方法回顾性分析162例前哨淋巴结活检技术的乳腺癌患者的临床资料,对乳腺癌临床病理指标与前哨淋巴结转移之间的关系进行因素分析。结果前哨淋巴结阳性共83例,前哨淋巴结阴性共79例。2组间的年龄、性别组成、体重指数、吸烟史和饮酒史等的差异均无统计学意义(P>0.05)。原发肿瘤位置、活检方式与前哨淋巴结转移无关(P>0.05),但病理类型与前哨淋巴结转移有关。随着肿瘤的变大,灵敏度、特异性也随之升高。多元Logistic回归分析显示,肿瘤直径和病理类型是影响前哨淋巴结转移的独立危险因素(P<0.05)。结论乳腺癌前哨淋巴结转移考虑与肿瘤大小及病理类型相关,但具体病例需具体分析后考虑是否可行前哨淋巴结活检术。 展开更多
关键词 乳腺癌 前哨淋巴结 转移
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Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways
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作者 Jing Wang Man Wu +7 位作者 Dan Zheng Hong Zhang Yue Lv Li Zhang Hong-sheng Tan Hua Zhou Yuan-zhi Lao Hong-xi Xu 《中国药理学报:英文版》 SCIE CAS CSCD 2020年第1期82-92,共11页
Metastasis causes the main lethality in esophageal cancer patient.Garcinol,a natural compound extracted from Gambogic genera,is a histone acetyltransferase(HAT)inhibitor that has shown anticancer activities such as ce... Metastasis causes the main lethality in esophageal cancer patient.Garcinol,a natural compound extracted from Gambogic genera,is a histone acetyltransferase(HAT)inhibitor that has shown anticancer activities such as cell cycle arrest and apoptosis induction.In this study,we investigated the effects of garcinol on the metastasis of esophageal cancer in vitro and in vivo.We found that garcinol(5-15μM)dose-dependently inhibited the migration and invasion of human esophageal cancer cell lines KYSE150 and KYSE450 in wound healing,transwell migration,and Matrigel invasion assays.Furthermore,garcinol treatment dose-dependently decreased the protein levels of p300/CBP(transcriptional cofactors and HATs)and p-Smad2/3 expression in the nucleus,thus impeding tumor cell proliferation and metastasis.Knockdown of p300 could inhibit cell metastasis,but CBP knockdown did not affect the cell mobility.It has been reported that TGF-β1 stimulated the phosphorylation of Smad2/3,which directly interact with p300/CBP in the nucleus,and upregulating HAT activity of p300.We showed that garcinol treatment dose-dependently suppressed TGF-β1-activated Smad and non-Smad pathway,inhibiting esophageal cancer cell metastasis.In a tail vein injection pulmonary metastasis mouse model,intraperitoneal administration of garcinol(20 mg/kg)or 5-FU(20 mg/kg)significantly decreased the number of lung tumor nodules and the expression levels of Ki-67,p300,and p-Smad2/3 in lung tissues.In conclusion,our study demonstrates that garcinol inhibits esophageal cancer metastasis in vitro and in vivo,which might be related to the suppression of p300 and TGF-β1 signaling pathways,suggesting the therapeutic potential of Garcinol for metastatic tumors. 展开更多
关键词 GARCINOL esophageal cancer metastasis histone acetyltransferase TGF-Β1 P300/CBP SMAD2/3
石榴皮鞣质对前列腺癌细胞侵袭转移影响的研究 预览
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作者 潘正波 张海涛 +2 位作者 蔡海荣 胡恩平 刘晟 《实用药物与临床》 CAS 2020年第2期117-121,共5页
目的探讨石榴皮鞣质对人前列腺癌PC-3细胞侵袭转移的影响。方法以人前列腺癌PC-3细胞为靶细胞,通过划痕愈合实验检测石榴皮鞣质对体外培养的PC-3细胞运动能力的影响;采用Transwell小室实验(无基质胶)检测石榴皮鞣质对PC-3细胞运动能力... 目的探讨石榴皮鞣质对人前列腺癌PC-3细胞侵袭转移的影响。方法以人前列腺癌PC-3细胞为靶细胞,通过划痕愈合实验检测石榴皮鞣质对体外培养的PC-3细胞运动能力的影响;采用Transwell小室实验(无基质胶)检测石榴皮鞣质对PC-3细胞运动能力的影响,采用Transwell小室实验(有基质胶)检测石榴皮鞣质对PC-3细胞侵袭能力的影响;采用裸鼠肺转移模型检测石榴皮鞣质对PC-3细胞体内侵袭能力的影响。结果划痕愈合实验结果显示,石榴皮鞣质能够抑制PC-3细胞的运动性,随着石榴皮鞣质浓度增加,其抑制PC-3细胞运动能力也逐渐增强,呈明显的浓度依赖性,与空白对照组比较差异有统计学意义(P<0.05);Transwell小室实验(无基质胶)显示,石榴皮鞣质能够抑制PC-3细胞运动;与空白对照组相比,随着石榴皮鞣质浓度增加,其降低PC-3细胞运动性也逐渐增强(P<0.05);Transwell小室(有基质胶)侵袭实验显示,与空白对照组相比,含有不同浓度石榴皮鞣质的实验组中,PC-3细胞穿膜细胞数即抑制其侵袭性得到有效抑制,与空白对照组相比,随着药物浓度的增加,其抑制侵袭性能力也逐渐增强(P<0.05);此外,裸鼠肺转移模型结果显示,石榴皮鞣质能够抑制PC-3细胞的侵袭性;与空白对照组相比,随着石榴皮鞣质浓度增加,PC-3细胞形成的肺转移瘤减少(P<0.05)。结论石榴皮鞣质对人前列腺癌PC-3细胞侵袭转移具有抑制作用,能抑制前列腺癌的侵袭转移。 展开更多
关键词 石榴皮鞣质 前列腺癌 侵袭 转移
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