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猪轮状病毒的分子流行病学研究进展 预览
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作者 苗艳 朱庆贺 +5 位作者 陈亮 李丹 李阳 兰世捷 徐馨 史同瑞 《动物医学进展》 北大核心 2020年第1期93-97,共5页
轮状病毒是引起儿童和幼龄动物急性胃肠炎的主要病因之一,在世界范围内广泛存在,是一种重要的人兽共患病病原。猪轮状病毒是引起哺乳仔猪和断奶仔猪急性胃肠炎的主要病原之一,有复杂的病原流行病学特征和遗传多样性。目前尚无针对该病... 轮状病毒是引起儿童和幼龄动物急性胃肠炎的主要病因之一,在世界范围内广泛存在,是一种重要的人兽共患病病原。猪轮状病毒是引起哺乳仔猪和断奶仔猪急性胃肠炎的主要病原之一,有复杂的病原流行病学特征和遗传多样性。目前尚无针对该病的有效治疗药物,疫苗接种仍是防控该病的主要措施。掌握猪轮状病毒的分子流行动态,可对诊断猪轮状病毒病和新型疫苗的研究提供科学依据。论文对猪轮状病毒的病原和分子流行病学调查结果进行了综述,旨在阐述不同地理区域中猪轮状病毒的流行特点,为进一步开展猪轮状病毒病原研究及后期疫苗和药物的研制提供参考。 展开更多
关键词 猪轮状病毒 病原学 基因型 分子流行病学
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Therapy to Obese Type 2 Diabetes Mellitus:How Far Will We Go Down the Wrong Road?
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作者 HENG Xian-pei LI Xiu-jun +3 位作者 LI Liang YANG Liu-qing WANG Zi-ta HUANG Su-ping 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2020年第1期62-71,共10页
Traditional glucose-lowering chemical agents, including various types of insulin and insulin secretagogues, insulin sensitizers, gliptins, etc., are based on diabetic pathogenesis of insulin resistance(IR) and islet i... Traditional glucose-lowering chemical agents, including various types of insulin and insulin secretagogues, insulin sensitizers, gliptins, etc., are based on diabetic pathogenesis of insulin resistance(IR) and islet insufficiency. Numerous evidence-based medical studies have shown that these traditional hypoglycemic chemical agents do not provide cardiovascular benefit to patients with type 2 diabetes mellitus(T2 DM) and may even increase the risk of all-cause mortality. Based on research evidence published to date, these studies show that overload of energy could increase the incidence and prevalence of T2 DM, and reduction in the heat load can significantly reduce the incidence of T2 DM. Therefore, the essence of T2 DM is heat overload, meaning heat overload is the etiology of obese T2 DM. At the same time, results of numerous studies show that heat overloading is the cause of IR. IR and islet dysfunction are protective factors in intervening with heat overload.These drugs, which are based on the mechanisms of IR and islet insufficiency, increase caloric reserve and cause or worsen obesity, which is equivalent to exacerbating the basic etiology and the cardiovascular risk factor of T2 DM. Thus, a reasonable strategy for prevention and treatment of obese T2 DM appears to promote the negative balance of calories and the elimination of caloric reserves. Chinese herbal medicines can promote negative balance of heat in many aspects, which can bring new hope for prevention and treatment of T2 DM. 展开更多
关键词 obese type 2 diabetes mellitus ETIOLOGY prevention and treatment Chinese herbal medicine
雏鹅痛风病研究进展 预览
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作者 徐丽娜 李晓林 罗济冠 《广东畜牧兽医科技》 2020年第1期19-22,共4页
雏鹅痛风病主要由新型鹅星状病毒引起,临床特征为内脏器官和关节有尿酸盐沉积。耐过鹅体重减轻、生长缓慢,易继发细菌感染,给养鹅业造成了巨大的经济损失。文章就近年来对雏鹅痛风病的研究进展进行综述,为该病的后期研究及防控提供依据。
关键词 雏鹅痛风病 新型鹅星状病毒 病原学 流行病学 诊断
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中国老年瓣膜性心脏病不同性别住院患者的流行病学特点:一项全国性多中心横断面研究 预览
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作者 张斌 许海燕 +2 位作者 高润霖 吴永健 China DVD研究组 《中国医刊》 CAS 2020年第1期26-30,共5页
目的探究中国老年瓣膜性心脏病(valvular heart disease,VHD)不同性别住院患者在疾病类型、病因分布及手术干预方面的差异。方法基于China DVD(China elDerly Valvular Disease;NCT02865798)全国多中心前瞻性队列,纳入年龄≥60岁的8638... 目的探究中国老年瓣膜性心脏病(valvular heart disease,VHD)不同性别住院患者在疾病类型、病因分布及手术干预方面的差异。方法基于China DVD(China elDerly Valvular Disease;NCT02865798)全国多中心前瞻性队列,纳入年龄≥60岁的8638例住院期间超声心动图发现中度及以上瓣膜病变的患者(排除了原队列中仅因既往瓣膜手术入院的患者),按照性别分层进行横断面描述。结果在8638例VHD患者中,男性占52.5%。在疾病类型上,男性主动脉瓣反流(aortic regurgitation,AR)和主动脉瓣狭窄(aortic stenosis,AS)的比例(分别为13.6%、6.0%)明显高于女性(分别为6.8%、3.9%),而二尖瓣狭窄(mitral stenosis,MS)的比例(1.8%)明显低于女性(5.0%),差异均有显著性(P<0.001)。无论男女,退行性变已逐渐成为AS、AR的首要病因,而MS则仍以风湿为主。但值得注意的是,二尖瓣反流患者中,男性缺血性病因占比仍略高于退行性变;而女性则以退行性变最常见。在1082例接受瓣膜手术的单纯左心VHD患者中,男性和女性的术后院内死亡率均低于5%。女性AS患者接受瓣膜手术的比例显著高于男性(分别为67.9%、55.4%,P=0.010),且术后院内死亡率有低于男性的趋势(分别为0.97%、4.73%,P=0.146);反之,在AR患者中,男性接受瓣膜手术的比例高于女性(分别为33.2%、24.2%,P=0.007),且术后院内死亡率有低于女性的趋势(分别为0.98%、4.34%,P=0.104)。在二尖瓣疾病中,男性和女性患者接受瓣膜手术的比例及术后院内死亡率均无明显差异。结论在中国老年VHD住院患者中,男性和女性患者的疾病类型、手术率存在明显差异,术后死亡率也有存在差异的趋势。 展开更多
关键词 瓣膜性心脏病 流行病学 病因学 性别分布
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住院患者低血糖症的病因分析及鉴别方法初探 预览
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作者 廖静 丁霏 +1 位作者 罗薇 李贵星 《国际检验医学杂志》 CAS 2020年第2期205-208,共4页
目的分析住院低血糖患者的病因及其构成情况,探究鉴别真性和假性低血糖的方法,建立低血糖结果的分析流程。方法回顾性分析2016年1月至2018年8月四川大学华西医院1413例低血糖住院患者的临床资料及实验室数据,按真性和假性低血糖、器质... 目的分析住院低血糖患者的病因及其构成情况,探究鉴别真性和假性低血糖的方法,建立低血糖结果的分析流程。方法回顾性分析2016年1月至2018年8月四川大学华西医院1413例低血糖住院患者的临床资料及实验室数据,按真性和假性低血糖、器质性和非器质性低血糖分类分析,并进一步将器质性和非器质性低血糖按病因分类分析。结果1413例低血糖患者中,病因明确的低血糖1147例(81.17%),病因不明的266例(18.83%)。1147例病因明确的低血糖患者中真性低血糖709例(61.81%),假性低血糖438例(38.19%)。病因明确的低血糖按具体病因分为器质性低血糖(n=149,12.99%)和非器质性低血糖(n=998,87.01%)2大类。149例器质性低血糖包括肝源性低血糖77例(51.68%),胰腺肿瘤性低血糖43例(28.86%),内分泌性低血糖18例(12.08%),反应性低血糖6例(4.03%),胰外肿瘤性低血糖3例(2.01%),胰岛素自身免疫综合征性低血糖2例(1.34%)。998例非器质性低血糖包括进食不足508例(50.90%),标本放置过久408例(40.88%),降糖药物使用不当52例(5.21%),红/白细胞增多30例(3.01%)。结论住院患者发生低血糖有真性和假性低血糖之分,同时,真性低血糖的病因复杂多样,临床工作中要准确诊断和鉴别诊断并采取正确的措施。 展开更多
关键词 真性低血糖 假性低血糖 病因 鉴别诊断
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青少年和成年人嵌甲的病因分析及其改良手术方法探讨 预览
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作者 欧阳阳钢 姜宗圆 +6 位作者 孙浩然 周林华 梁海 刘岸雄 陈琪 谢统明 黄晓瑜 《中国美容医学》 CAS 2020年第1期23-26,共4页
目的:探讨青少年及成年人嵌甲的病因,并对应用彻底切除两侧甲生发层的甲襞成形术治疗嵌甲的有效性进行分析。方法:选择2015年1月-2016年12月笔者医院收治的顽固性嵌甲症患者68例,其中青少年组:36例,成年组:32例;部位:单足第一趾60例,双... 目的:探讨青少年及成年人嵌甲的病因,并对应用彻底切除两侧甲生发层的甲襞成形术治疗嵌甲的有效性进行分析。方法:选择2015年1月-2016年12月笔者医院收治的顽固性嵌甲症患者68例,其中青少年组:36例,成年组:32例;部位:单足第一趾60例,双足第一趾8例;病程最短2个月,最长3年,平均4个月;复发次数最少1次,最多6次,平均3次。分析青少年及成年嵌甲发病原因,并对所有患者采用彻底切除两侧甲生发层的甲襞成形术进行治疗。结果:青少年嵌甲致病原因主要为穿不合适、过紧的鞋子,多汗;成年嵌甲致病原因主要为修剪趾甲不当、创伤性甲损伤。68例患者中,青少年组36例,术后伤口愈合时间(6±1.38)d,成年组32例,术后伤口愈合时间(8±1.68)d。青少年组随访3~24个月,平均19个月,优良率达97.2%,成年组随访2~22个月,平均17个月,优良率达93.8%。术后拇趾外露甲体宽度患侧为(16.36±0.17)mm,术前拇趾外露甲体宽度为(16.58±O.36)mm,术后趾甲形态满意。结论:青少年和成年嵌甲致病主要原因各不相同。彻底切除两侧生发层的甲襞成形术治疗嵌甲效果满意,可获得较好的美观外形。 展开更多
关键词 嵌甲 病因学 生发层 青少年 成年人 手术
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Successful treatment of congenital palate perforation: A case report 预览
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作者 Jin-Feng Zhang Wen-Bin Zhang 《世界临床病例杂志》 2020年第1期175-178,共4页
Congenital palate perforation is extremely rare.There is controversy about its exact etiology and appropriate management.Here,a case of congenital palatal perforation is reported.The diagnosis and treatment of the dis... Congenital palate perforation is extremely rare.There is controversy about its exact etiology and appropriate management.Here,a case of congenital palatal perforation is reported.The diagnosis and treatment of the disease are summarized.CASE SUMMARY A full-term neonate boy was referred for oral and craniomaxillofacial surgery with a finding of a hole in the palate at birth.The operation was postponed after pediatric consultation because of the patient’s poor nutrition and underweight for his age.At the age of 10 mo,the patient underwent modified von Langenbeck palatoplasty.He was followed for four years after surgery without any signs of re-rupture.His speech was satisfactory.CONCLUSION Considering the anatomy and etiology,congenital palate perforation can be classified as isolated or associated with submucous cleft palate,and the treatment procedure should be altered accordingly. 展开更多
关键词 CONGENITAL PALATE PERFORATION CRANIOMAXILLOFACIAL Submucous cleft palate etiology von Langenbeck palatoplasty
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新疆北疆某规模化牛场奶牛副结核病的检测与分析 预览
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作者 高建鹏 赵鑫 +3 位作者 高静雯 李慧 张莉 齐亚银 《中国动物传染病学报》 CAS 北大核心 2020年第1期74-79,共6页
为查明导致新疆北疆某规模化牛场奶牛腹泻、消瘦的主要病原菌,本研究采用微生物学与分子生物学方法对采集的患牛粪便进行检测与鉴定。结果显示:2份粪样抗酸染色阳性,IS900基因及亚型分型基因检测阳性,IS900基因与GenBank中多个副结核分... 为查明导致新疆北疆某规模化牛场奶牛腹泻、消瘦的主要病原菌,本研究采用微生物学与分子生物学方法对采集的患牛粪便进行检测与鉴定。结果显示:2份粪样抗酸染色阳性,IS900基因及亚型分型基因检测阳性,IS900基因与GenBank中多个副结核分枝杆菌序列同源性在99%以上,亚型分型基因与Ⅱ型同源性为99.81%,从而确定2份样本均被Ⅱ型(牛型)副结核分枝杆菌感染。 展开更多
关键词 副结核分枝杆菌 奶牛 病原检测
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乳腺神经鞘瘤的诊治进展
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作者 任航军 姜昌镐 《中国普外基础与临床杂志》 CAS 2020年第1期123-126,共4页
目的对乳腺神经鞘瘤进行再认识,以提高其诊断率及治愈率。方法检索乳腺神经鞘瘤的相关文献,对该病的起源、病因、临床表现、影像学特点、病理学特点、治疗及预后的相关知识进行分析并综述。结果乳腺神经鞘瘤十分罕见,起源于神经鞘膜雪... 目的对乳腺神经鞘瘤进行再认识,以提高其诊断率及治愈率。方法检索乳腺神经鞘瘤的相关文献,对该病的起源、病因、临床表现、影像学特点、病理学特点、治疗及预后的相关知识进行分析并综述。结果乳腺神经鞘瘤十分罕见,起源于神经鞘膜雪旺细胞,其具体病因不明且临床表现无特异性,与其他乳腺疾病之间难以鉴别,如叶状囊肉瘤、乳腺血管外皮细胞瘤、乳腺纤维腺瘤等。影像学资料可提供一定的参考价值,但金标准依赖于病理学及免疫组织化学检查。手术能治愈良性乳腺神经鞘瘤,但有恶变可能,须术后随访。恶性神经鞘瘤以手术切除为主,辅以放化疗,可有效预防肿瘤局部复发和远处转移。乳腺神经鞘瘤的预防可参考乳腺癌筛查。结论临床实践中需了解乳腺神经鞘瘤的诊断与治疗,争取做到早发现、早诊断和早治疗,提高该病的诊断率及治愈率,以保护女性的身心健康。 展开更多
关键词 乳腺神经鞘瘤 起源 病因 临床表现 治疗 综述
石家庄地区儿童社区获得性肺炎临床症状、病原学和流行病学分析 预览
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作者 莫亚玲 张剑霄 +2 位作者 孟艳 张古英 赵德运 《临床肺科杂志》 2020年第1期46-49,53,共5页
目的探讨石家庄地区儿童社区获得性肺炎临床症状,病原菌分布和流行病学,为本地区合理使用抗感染治疗提供依据。方法选择1047例确诊为CAP患儿作为研究对象,收集病例信息,取呼吸道分泌物做细菌培养,采用酶联免疫法检测呼吸道病原菌,整理... 目的探讨石家庄地区儿童社区获得性肺炎临床症状,病原菌分布和流行病学,为本地区合理使用抗感染治疗提供依据。方法选择1047例确诊为CAP患儿作为研究对象,收集病例信息,取呼吸道分泌物做细菌培养,采用酶联免疫法检测呼吸道病原菌,整理不同病原体感染患儿临床特点,应用SPSS 19.0软件对病原学和流行病学综合分析。结果1047例CAP患儿主要临床症状以中、高热、咳嗽、干咳为主,构成比分别为62.18%、47.18%、37.15%;共检测出641例患儿的病原学类型,统计分析得出:CAP患儿性别间的感染类型分布差异不明显,无统计学意义(P>0.05);支(衣)原体、混合感染性2~5岁、秋季最多,病毒性、细菌性<1岁、冬季最多,年龄、季节间感染类型分布均有统计学意义(P>0.05);不同感染类型CAP患儿构成情况:支(衣)原体、病毒性、细菌性、混合感染性,分别为359、95、77、110例,其中支(衣)原体最多,占比56.01%,细菌感染中肺炎链球菌最多,占比32.47%,细菌感染患儿年龄中1岁以下儿童细菌感染最多59.75%;患儿人群分布:不同感染类型CAP以散居儿童为主,远高于幼托儿童、学生及其他儿童。结论石家庄地区儿童社区获得性肺炎的感染病原学呈多样化,CAP患儿病原菌中,肺炎支原体为常见,细菌培养以肺炎链球菌最为常见,为临床针对性治疗及减少抗菌药物的不合理使用提供依据。 展开更多
关键词 社区获得性肺炎 临床症状 病原学 流行病学 儿童
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支气管镜及肺泡灌洗术在婴幼儿反复喘息性疾病中的应用 预览
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作者 吴金凤 张新星 +8 位作者 顾文婧 季伟 严永东 陈正荣 郝创利 王美娟 谭嘉红 张佳惠 黄莉 《临床儿科杂志》 CAS CSCD 北大核心 2020年第1期6-9,共4页
目的探讨支气管镜及肺泡灌洗术在婴幼儿反复喘息性疾病诊疗中的作用及价值。方法收集415例1~36月龄反复喘息患儿支气管镜检结果及肺泡灌洗液(BALF),采用直接免疫荧光法检测7种常见呼吸道病毒,荧光定量PCR法检测肺炎支原体、肺炎衣原体... 目的探讨支气管镜及肺泡灌洗术在婴幼儿反复喘息性疾病诊疗中的作用及价值。方法收集415例1~36月龄反复喘息患儿支气管镜检结果及肺泡灌洗液(BALF),采用直接免疫荧光法检测7种常见呼吸道病毒,荧光定量PCR法检测肺炎支原体、肺炎衣原体及博卡病毒,RT-PCR法检测鼻病毒及偏肺病毒等,并行细菌培养及细胞形态学检查。选取同期因支气管肺炎或大叶性肺炎伴有肺不张表现住院并行支气管镜及肺泡灌洗的106例非喘息患儿作为对照组,收集其BALF行细胞形态学检查。结果415例喘息患儿中,男317例、女98例,支气管镜下表现为支气管内膜炎症405例,占97.6%,其次为气管软化69例,占16.6%。BALF检出病原体以肺炎支原体最常见,159例,占38.3%;其次为细菌74例,占17.8%,以肺炎链球菌和流感嗜血杆菌为主;病毒69例,占16.6%,以人博卡病毒为主。反复喘息患儿BALF中性粒细胞及嗜酸性细胞比例高于非喘息患儿,而吞噬细胞比例低于非喘息患儿,差异均有统计学意义(P<0.05)。结论支气管镜检查可以为反复喘息患儿的早期诊断和治疗提供有效帮助。 展开更多
关键词 反复喘息 支气管镜 肺泡灌洗液 病原学 细胞形态学
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100 Cases of Clinical and Etiological Aspects of Cardiac Insufficiency in N’Djamena, Chad 预览
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作者 Natingar Madjirangar Adam Ahamat Ali +1 位作者 Bekoutou Amngar Jean Philippe Lesbre 《心血管病(英文)》 2019年第8期612-619,共8页
Introduction: Cardiac Insufficiency is progressively taking over as the leading cause of morbidity and mortality in the world and a major public health problem in Chad. Our study was to contribute and provide a deeper... Introduction: Cardiac Insufficiency is progressively taking over as the leading cause of morbidity and mortality in the world and a major public health problem in Chad. Our study was to contribute and provide a deeper understanding of the clinical and etiological aspects concerning the etiology and management of Cardiac Insufficiency in N’Djamena, Chad. Due to having no published data to distinctly understand this pathology in this part of the world, we represent here a summary of available data which could be used to describe the clinical and etiological aspects of Cardiac Insufficiency and to help in changing practices for an optimal management as a baseline for comparison in future studies. Patients and Methods: This was a prospective, descriptive study conducted from November 30th 2011 to May 30th 2013 at the Good Samaritan Hospital of N’Djamena. Results: 100 hospitalized patients were included consecutively. The sex ratio was 1.08 with an average age of 40.21 ± 21.30 years. The main cardiovascular risk factors were high blood pressure (15%), obesity (12%) and diabetes (11%). Clinically, exertional dyspnea was found in 95% of cases, and signs of congestive heart failure in 61% of cases. The etiologies were 50% of Rheumatic valvulopathy, 22% of Dilated cardiomyopathy, 13% of Hypertensive cardiomyopathy and 12% of Congenital heart disease. Conclusion: The most common etiologies were Rheumatic valvulopathy, Congenital heart disease, Dilated cardiomyopathy and Hypertensive cardiomyopathy. 展开更多
关键词 CARDIAC INSUFFICIENCY ETIOLOGY ECHOCARDIOGRAPHY N’Djamena CHAD
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F&#339;tal Death in Utero: Maternal Epidemiological and Prognostic Aspects at Sylvanus Olympio Teaching Hospital in Lomé 预览
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作者 Baguilane Douaguibe A. S. Aboubakari +6 位作者 A. Bassowa D. Ajavon T. Ketevi K. E. Logbo-Akey B. Baramna K. Fiagnon K. Akpadza 《妇产科期刊(英文)》 2019年第4期511-520,共10页
The fetal death In Uterus is relatively a common problem in developing countries. In Africa, the rate of deaths varies from one hospital to another. We wanted to evaluate the prevalence, to describe the epidemiologica... The fetal death In Uterus is relatively a common problem in developing countries. In Africa, the rate of deaths varies from one hospital to another. We wanted to evaluate the prevalence, to describe the epidemiological aspects, etiologies and maternal prognosis associated with fetal deaths in Uterus in 2017 at Sylvanus Olympio Teaching Hospital in Lomé. Patients and methods: This was a retrospective descriptive study conducted from January 1st to December 31st, 2017. We have included all pregnant cases received and treated on the spot for in uterus deaths as defined by the World Health Organization. Medical termination of pregnancy records, intrapartum deaths, less than 22 amenorrhea weeks’ pregnancies and complications of abortion were not included. Results: The fetal death rate in uterus was 3.64%. The multigravida and multiparous were respectively 49% and 41%;the referees were 51%, 28% evacuated;21% came on their own. The gestational age of 28 - 37 weeks was 39% and 17% had no prenatal consultation. The analysis has revealed that high blood pressure, preeclampsia, and retroplacental hematomas were the main etiologies associated with fetal deaths in uterus. Conclusion: In uterus fetal deaths remain common in our country. The main causes were hypertension disorders of pregnancy. There were also some unknown causes which could be related to economic or cultural reasons. For instance, autopsies of in uterus deaths and placental anatomopathology examination are not performed because of culture. 展开更多
关键词 Fetal DEATH in UTERUS ETIOLOGY MATERNAL Prognosis
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Clinic Evaluation of Heart Failure of Old People in the Department of Internal Medicine of Point G University Hospital from 2008 to 2012 预览
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作者 Assétou Soukho Kaya Abdel Kader Traoré +17 位作者 Djibril Sy Djenebou Traoré Ilo Diall Youssouf Fofana Ibahima Amadou Dembélé Boua Daoud Camara Mamadou Saliou Karim Dao Mamadou Cissoko Kaly Kéï ta Barry Boubacar Sangaré Mamadou Mallé Alassane A. Doumbia Hadiza A. Kaï lou Mamadou Dembélé Hamar Alassane Traoré 《内科学期刊(英文)》 2019年第3期83-88,共6页
Justification: Heart failure (HF) is the evolutionary end of all cardiac diseases. Given the aging population, the rate of incidence is increasing among the elderly. Objectives: The study aims to determine the prevale... Justification: Heart failure (HF) is the evolutionary end of all cardiac diseases. Given the aging population, the rate of incidence is increasing among the elderly. Objectives: The study aims to determine the prevalence of heart failure in the elderly;to describe the clinical aspects;describe etiologies;describe the therapeutic aspects;and describe the evolution of heart failure among the elderly. Method: This was a retrospective study over five years on the operating records of patients hospitalized in the internal medicine department of Hospital Point G. Result: The study included records of 22 elderly patients who were with heart failure of a total of 595 patients hospitalized from 1st January 2008 to 31st December 2012. The prevalence rate was 3.7%, and the average age was 67 ± 7.79 years. The sex ratio was equal to 1. HTA accounted for the cardiovascular risk factors in 77.3%. 72.7% of patients had the symptom of dyspnea and 95.5% of patients had the symptom of IMO. According to the cardiac ultrasound, dilation of the OG represented 68.2% of cases, followed by impaired LVEF (63.6%). The etiologies of IC were represented by dilated cardiomyopathy (95.5%), followed by 13.6% in cardiothyreosis. Drug treatment was dominated by the use of diuretics, ACE inhibitors and sodium diet respectively 95.5%;81.8% and 45.5% of cases. The clinical outcome was favorable in 73%. We recorded four (4) cases of death, which accounted for 18% of patients. 展开更多
关键词 HEART Failure CLINIC ETIOLOGY THERAPEUTICS The ELDER
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Etiology and Short Term Outcome of Neonatal Convulsion in NICU at Benghazi Children Hospital 预览
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作者 Mohanad Abdulhadi Saleh Lawgali Faiaz Ragab Salem Halies Amina M. Beayou 《神经系统科学与医药(英文)》 2019年第4期369-384,共16页
Background: Neonatal seizures are the most prominent feature of neurological dysfunction during neonatal period, which are abnormal electrical discharges in the central nervous system of neonates, usually manifest as ... Background: Neonatal seizures are the most prominent feature of neurological dysfunction during neonatal period, which are abnormal electrical discharges in the central nervous system of neonates, usually manifest as stereotyped muscular activity or autonomic changes, occurring in approximately 1.8 - 3.5/1000 live birth. Objective: The aims of study are to determine prevalence rate, natural history, time of onset, etiological factors, clinical types and the short term outcome of neonatal convulsion. Settings: This study conducted in Neonatal Department at Benghazi Children Hospital—Libya. Patients and Methods: Descriptive cross sectional study, included all neonates who developing clinically identifiable seizures, admitted from 1st of March 2013 to 1st of March 2014. The data collected by using a designed perform including;gender, nationality, residence, place of transfer, gestational age, time of onset, mode of delivery, and history of maternal diseases, family history of neonatal seizures in previous siblings or death, jaundice and exchange transfusion were taken. Details examination include dysmorphic features, weight, head circumference were recorded. Types of seizures were diagnosed by clinical observations, and the etiology of neonatal seizures had been identified from imaging study and from initial relevant investigations which include blood glucose levels, arterial blood gases, serum calcium, electrolytes, phosphate and cerebrospinal fluid examination for evidence of infection. In addition to treatments received, as well as causes of deaths. Results: A total of 2842 neonates were admitted to NNW, out of which 150 had seizures. 86 (57%) were male with M:F ratio of 1.3:1. (97%) were Libyan and (76%) from Benghazi, (42%) admitted directly from home. 131 (87%) were term and 15 (10%) preterm. Most of neonatal seizures (76%) were seen in the 1st week of life, and during initial 72 hours of life (63%), with 24% presented in 1st 24 hours of life. Vaginal delivery conducted in 101 (67%), C/S 49 (33%). Among babi 展开更多
关键词 NEONATAL CONVULSIONS Types ETIOLOGY INTENSIVE Care Benghazi Libya
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继发性膜性肾病的病因研究现状 预览
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作者 秦冬冬 丁庆龙 《中国中医药现代远程教育》 2019年第6期154-156,共3页
膜性肾病(MN)根据病因可分为特发性膜性肾病(IMN)和继发性膜性肾病(SMN),随着近些年的研究发现,临床中膜性肾病的发病率在逐渐升高,而引起SMN的病因包括自身免疫性疾病、感染性疾病、肿瘤、药物及重金属等,其中以自身免疫性疾病因素居... 膜性肾病(MN)根据病因可分为特发性膜性肾病(IMN)和继发性膜性肾病(SMN),随着近些年的研究发现,临床中膜性肾病的发病率在逐渐升高,而引起SMN的病因包括自身免疫性疾病、感染性疾病、肿瘤、药物及重金属等,其中以自身免疫性疾病因素居多。近些年受环境污染的影响,特别是环境中PM2.5的影响,研究发现其与膜性肾病的发病率存在一定关系。本文就继发性膜性肾病(SMN)的中西医病因做以下综述。 展开更多
关键词 继发性膜性肾病 病因 水肿
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慢性胃炎的治疗策略 预览
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作者 牛巍巍 张晓岚 《临床荟萃》 CAS 2019年第5期412-415,共4页
慢性胃炎是临床最为常见的疾病之一,随着年龄的增长发病率呈现逐年上升的趋势,其不但影响人们的生活质量,并且对人类的健康造成了严重的威胁,因此,慢性胃炎的治疗显得尤为重要。本文将根据病因及临床症状等方面对慢性胃炎进行分类,分别... 慢性胃炎是临床最为常见的疾病之一,随着年龄的增长发病率呈现逐年上升的趋势,其不但影响人们的生活质量,并且对人类的健康造成了严重的威胁,因此,慢性胃炎的治疗显得尤为重要。本文将根据病因及临床症状等方面对慢性胃炎进行分类,分别阐述各种类型慢性胃炎的治疗策略,为规范慢性胃炎治疗提供帮助。 展开更多
关键词 慢性胃炎 幽门螺杆菌 治疗 病因
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稽留流产细胞遗传学病因分析及生化指标检测的临床意义 预览
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作者 龙驭云 汤欣欣 +3 位作者 顾莹 杨舒婷 孙玉华 金培芹 《中国计划生育学杂志》 2019年第7期902-904,共3页
目的:探究稽留流产中细胞遗传学病因分析及生化指标的临床意义。方法:2015年1月—2017年3月本院确诊的稽留流产患者98例(观察组),同期自愿终止妊娠的早孕妇女98例(对照组)。收集两组绒毛组织应用G显带技术进行细胞核型分析,免疫组化技... 目的:探究稽留流产中细胞遗传学病因分析及生化指标的临床意义。方法:2015年1月—2017年3月本院确诊的稽留流产患者98例(观察组),同期自愿终止妊娠的早孕妇女98例(对照组)。收集两组绒毛组织应用G显带技术进行细胞核型分析,免疫组化技术检测绒毛组织中人基质金属蛋白酶(MMP-9)、凝血酶敏感蛋白-1(TSP-1)表达。结果:对照组的核型均为44+XX或44+XY,观察组核心分析失败42例,成功56例中,单体-XO6例,单体-常1例,三体35例,嵌合7例,缺失重复6例;对照组MMP-9阳性率高于观察组,TSP-1表达水平低于观察组(P<0.05)。结论:对稽留流产绒毛组织进行细胞核型分析,对病因进行诊断,可为下一胎孕育做出指导。MMP-9、TSP-1可作为稽留流产辅助诊断指标。 展开更多
关键词 稽留流产 病因 绒毛组织 细胞遗传学 核型分析
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离子通道基因突变致早发癫痫性脑病17例临床特征和基因突变分析
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作者 刘晓军 韦新平 +6 位作者 吴波 雷梅芳 张培元 于晓莉 李东 李鸿 张玉琴 《中华实用儿科临床杂志》 CSCD 北大核心 2019年第12期918-921,共4页
目的分析离子通道基因突变致早发癫痫性脑病的临床特征和基因突变,明确病因,指导治疗,并为遗传咨询提供依据。方法收集2014年6月至2018年5月天津市儿童医院神经内科收治的17例离子通道基因突变致早发癫痫性脑病患儿临床资料和患儿及其... 目的分析离子通道基因突变致早发癫痫性脑病的临床特征和基因突变,明确病因,指导治疗,并为遗传咨询提供依据。方法收集2014年6月至2018年5月天津市儿童医院神经内科收治的17例离子通道基因突变致早发癫痫性脑病患儿临床资料和患儿及其父母外周血样本,应用疾病基因靶向二代测序技术进行癫痫基因测序分析,发现致病性离子通道基因突变,被证实的突变均用Sanger测序验证,并明确突变的来源。结果17例早发癫痫性脑病患儿中,3例为遗传性基因突变,14例为新生基因突变。其中Dravet综合征8例(47.1%),5例为SCN1A基因错义突变,3例为SCN1A基因无义突变;大田原综合征1例(5.9%)为KCNQ2基因错义突变;非特异性癫痫性脑病8例(47.1%),发现可疑致病性突变中SCN2A基因错义突变、SCN4A基因错义突变、SCN8A基因错义突变、KCNQ2基因错义突变、KCNH5基因错义突变、CACNA1A基因错义突变、GRIN2A基因错义突变、GRIN3A基因错义突变各1例。17例均予2种及2种以上抗癫痫药物治疗,4例予生酮饮食,1例补充维生素B6辅助抗癫痫治疗。随访11~96个月,3例(17.6%)癫痫发作完全控制,7例(41.2%)癫痫发作减少≥50%,7例(41.2%)癫痫发作减少<50%。结论早发癫痫性脑病临床表型多样,离子通道基因突变是最常见的遗传性病因。本研究发现3例SCN1A基因错义突变、2例SCN1A基因无义突变、1例SCN2A基因错义突变、1例CACNA1A基因错义突变,1例KCNH5基因错义突变为未见报道新发位点突变,丰富了早发癫痫性脑病的相关离子通道基因型。 展开更多
关键词 早发癫痫性脑病 离子通道 病因 基因突变
复发性肝内胆管结石病因机制及外科治疗研究进展 预览
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作者 范海军 田大广(综述) 魏晓平(审校) 《中国临床新医学》 2019年第9期1029-1034,共6页
肝内胆管结石(intrahepatic bile duct stones,IBDS)是肝胆外科的常见病,其病因复杂,治疗难度大,术后复发率高、并发症多,严重影响患者的生活质量。目前临床上IBDS的复发机制研究尚未完全清楚,可能与细菌寄生虫感染、胆管炎反复发作和... 肝内胆管结石(intrahepatic bile duct stones,IBDS)是肝胆外科的常见病,其病因复杂,治疗难度大,术后复发率高、并发症多,严重影响患者的生活质量。目前临床上IBDS的复发机制研究尚未完全清楚,可能与细菌寄生虫感染、胆管炎反复发作和胆汁淤滞、遗传环境与饮食代谢及初次治疗方式及时机选择等有关。随着现代医疗技术发展,IBDS的各种治疗方式层出不穷,精准肝切除术、经皮肝胆道镜取石术(PTCS)、各种内镜及碎石技术微创外科等发展迅速。该文主要对IBDS复发的病因机制及其治疗研究进展作一综述,旨在为临床治疗及IBDS的术后复发预防提供一定依据,以期减轻患者病痛并提高其生活质量。 展开更多
关键词 肝内胆管结石 复发 病因学 精准肝切术 经皮肝胆道镜取石术
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