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主要 sclerosing 胆管炎的管理 认领
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作者 Holger H Lutz Jens JW Tischendorf 《世界肝病学杂志:英文版(电子版)》 2011年第6期137-141,共5页
Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease with major morbidity and mortality.Therapeutic management is difficult,due to lack of conclusive data and individual disease progression.High-d... Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease with major morbidity and mortality.Therapeutic management is difficult,due to lack of conclusive data and individual disease progression.High-dose UDCA was used for years as a pharmacotherapeutic agent to prevent disease progression,based on a positive trend in pilot studies,but has recently been proven to have a negative effect in advanced disease.Immunosuppressants might be useful in patients with overlap syndromes.Dominant bile duct stenoses should be treated endoscopically,and cholangiocellular carcinoma (CCC) still remains a therapeutic challenge in PSC patients.Early diagnosis of CCC must be improved and new strategies such as neoadjuvant radiochemotherapy with subsequent liver transplantation in selected patients are further options to be considered. 展开更多
关键词 Primary SCLEROSING CHOLANGITIS Ursodeoxycholic acid NorUDCA Cholangiocellular CARCINOMA Cholestatic liver disease ENDOSCOPY DOMINANT stenoses
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