期刊文献+
共找到20,143篇文章
< 1 2 250 >
每页显示 20 50 100
循证护理与单纯全程陪产护理模式在产科分娩中的对比分析 认领
1
作者 闫萍 《中国医药指南》 2020年第20期18-20,共3页
目的探讨循证护理与单纯全程陪产护理模式在产科分娩中的效果。方法将我院产科于2017年5月至2018年10月收治的158例分娩患者为研究对象,以计算机随机化原则分为观察组(循证全程陪产护理组,78例)和对照组(单纯全程陪产护理组,80例)2组,比... 目的探讨循证护理与单纯全程陪产护理模式在产科分娩中的效果。方法将我院产科于2017年5月至2018年10月收治的158例分娩患者为研究对象,以计算机随机化原则分为观察组(循证全程陪产护理组,78例)和对照组(单纯全程陪产护理组,80例)2组,比较2组的分娩总产程用时、出血量及新生儿Apgar评分,评价患者对护理的满意度。结果观察组分娩患者总产程用时、出血量低于对照组,新生儿Apgar评分高于对照组;观察组护理满意度高于对照组,对比差异P<0.05。结论产科分娩患者应用循证全程陪产护理较单纯全程陪产护理而言,尽可能的改善分娩条件,能明显缩短产程用时,减少出血量,改善分娩结局。 展开更多
关键词 分娩 循证护理 单纯全程陪产护理模式 分娩结局
在线阅读 免费下载
以家庭为中心分娩体验产前教育在产妇中的应用研究 认领
2
作者 庾瑞华 朱凤明 梁洁贞 《中国卫生标准管理》 2020年第13期151-153,共3页
目的探究分析以家庭为中心分娩体验产前教育在产妇中的应用效果。方法选取2018年1月—2019年6月于我院妇产科接受产前检查的120例产妇作为研究对象,依据家属参与情况分为试验组60例与参照组60例,试验组实施以家庭为中心的一体化分娩体... 目的探究分析以家庭为中心分娩体验产前教育在产妇中的应用效果。方法选取2018年1月—2019年6月于我院妇产科接受产前检查的120例产妇作为研究对象,依据家属参与情况分为试验组60例与参照组60例,试验组实施以家庭为中心的一体化分娩体验产前教育,整个过程中家属参与,参照组实施常规产前教育,整个过程中家属未参与。对比分析两组产妇分娩方式、焦虑情况及母乳喂养状况。结果试验组阴道分娩率、母乳喂养率显著高于参照组,有统计学差异,P<0.05;试验组焦虑评分显著低于参照组,有统计学差异,P<0.05。结论对产妇实施以家庭为中心的一体化分娩体验模式,可降低产妇焦虑情况,促进母乳喂养及自然分娩率提升。 展开更多
关键词 母乳喂养 分娩方式 分娩体验 产前教育 阴道分娩率 焦虑
在线阅读 下载PDF
支持性护理干预对分娩期女性分娩恐惧与分娩结局的影响 认领
3
作者 蔡娜 闫丽娜 《河北医药》 CAS 2020年第1期151-153,156共4页
目的探讨支持性护理干预对分娩期妇女分娩恐惧与分娩结局的影响。方法选择2017年1~12月定期产检的120例分娩期女性,按照随机数字表法分为支持性护理干预组(试验组,n=60)和常规护理干预组(对照组,n=60)。比较2组患者干预前分娩恐惧、分... 目的探讨支持性护理干预对分娩期妇女分娩恐惧与分娩结局的影响。方法选择2017年1~12月定期产检的120例分娩期女性,按照随机数字表法分为支持性护理干预组(试验组,n=60)和常规护理干预组(对照组,n=60)。比较2组患者干预前分娩恐惧、分娩结局等方面的差异。结果干预后,2组在分娩恐惧量表评分、疼痛评分高于干预前,差异有统计学意义(P<0.05)。2组患者干预后,试验组在分娩恐惧量表评分(潜伏期)、疼痛评分(潜伏期、活跃期)、催产素使用情况、产后出血量与对照组相比,差异均无统计学意义(P>0.05);试验组分娩恐惧量表评分(活跃期、过渡期)、疼痛评分(过渡期)、产程方面均低于对照组,差异有统计学意义(P<0.05);试验组分娩控制感量表评分、分娩自我效能量表评分、新生儿Apgar评分均高于对照组,差异有统计学意义(P<0.05)。试验组护理满意度为96.67%高于对照组的86.67%,差异有统计学意义(P<0.05)。结论支持性护理干预可减轻分娩期女性在分娩过程中的分娩恐惧和疼痛,改善分娩结局,提高其对护理工作的满意度。 展开更多
关键词 支持性护理 分娩 分娩恐惧 分娩结局
在线阅读 下载PDF
分娩球联合COOK球囊在足月引产中的应用价值 认领
4
作者 江簪 《中国民康医学》 2020年第6期31-33,共3页
目的:探讨分娩球联合COOK球囊在足月引产中的应用价值。方法:选取94例足月引产产妇为研究对象,按照随机数字表法分为对照组与研究组各47例。对照组采用COOK球囊促宫颈成熟,研究组采用分娩球联合COOK球囊促宫颈成熟,比较两组的产程时间... 目的:探讨分娩球联合COOK球囊在足月引产中的应用价值。方法:选取94例足月引产产妇为研究对象,按照随机数字表法分为对照组与研究组各47例。对照组采用COOK球囊促宫颈成熟,研究组采用分娩球联合COOK球囊促宫颈成熟,比较两组的产程时间、诱导有效宫缩时间、分娩结局、治疗满意度。结果:研究组第一、第二产程时间短于对照组,诱发有效宫缩时间短于对照组,差异均有统计学意义(P<0.05);研究组中转剖宫产率低于对照组,差异有统计学意义(P<0.05);两组产后出血、产褥期感染、产后尿潴留、新生儿窒息率比较,差异无统计学意义(P>0.05);研究组产妇治疗满意度为93.62%,高于对照组的76.60%,差异有统计学意义(P<0.05)。结论:足月引产中应用分娩球联合COOK球囊可缩短第一、第二产程时间及诱发有效宫缩时间,降低中转剖宫产率,提升治疗满意度。 展开更多
关键词 产妇 分娩 分娩球 COOK球囊
在线阅读 下载PDF
Magnetic nanoparticle drug targeting to patient-specific atherosclerosis: effects of magnetic field intensity and configuration 认领
5
作者 Xuelan ZHANG Mingyao LUO +2 位作者 Peilai TAN Liancun ZHENG Chang SHU 《应用数学和力学:英文版》 SCIE EI CSCD 2020年第2期349-360,共12页
Nanoparticle-mediated drug delivery is recognized as a promising option for targeted treatment of atherosclerosis. In this paper, the Eulerian-Lagrangian technique is adopted to simulate the delivery of drug-loaded na... Nanoparticle-mediated drug delivery is recognized as a promising option for targeted treatment of atherosclerosis. In this paper, the Eulerian-Lagrangian technique is adopted to simulate the delivery of drug-loaded nanoparticles to patient-specific atherosclerotic plaque with the aid of an external magnetic field. Plaques and vascular walls are introduced as porous media formulated by the Darcy-Forchheimer model in this targeted transport process. The results demonstrate that the delivery efficiency of particles to atherosclerosis depends on the external magnetic field, such as configuration and intensity, in which the configuration angle of the current wire is a key factor and the double current wires have advantages over the single current wire. Meanwhile, the delivery efficiency gradually decreases as the distance between the plaque cap and the current wire increases. Further, although augmenting the current or magnetic susceptibility can generally improve the delivery efficiency of nanoparticles, this increase is not apparent when small-sized nanoparticles are employed as drug transport particles. The results obtained can potentially serve as the guideline to optimize regimens for the targeted therapy of atherosclerosis. 展开更多
关键词 ATHEROSCLEROSIS nanoparticle-mediated drug delivery magnetic field TARGETED delivery efficacy COMPUTATIONAL fluid dynamics
在线阅读 下载PDF
Effect of China's Universal Two-child Policy on the Rate of Cesarean Delivery: A Case Study of a Big Childbirth Center in China 认领
6
作者 Shu-guo DU Fei TANG +4 位作者 Yun ZHAO Guo-qiang SUN Ying LIN Zhi-hua TAN Xu-feng WU 《当代医学科学(英文)》 SCIE CAS 2020年第2期348-353,共6页
China's universal two child policy was released in October of 2015.How would this new policy influence the rate of overall cesarcan delivery(CD)in China?The objective of this paper is to investigate the trend of o... China's universal two child policy was released in October of 2015.How would this new policy influence the rate of overall cesarcan delivery(CD)in China?The objective of this paper is to investigate the trend of overall CD rate with the increase of number of multiparous women based on a big childbirth center of China(a tertiary hospital)in 2016.In this study,22530 cases from the medical record department of a big childbirth center of China from January 1 to December 31 in 2016 were entolled as research objects.Electronic health records of these selected objects were retrieved.According t0 the history of childbirth,the selected cases were divided into primiparous group containing 16340 cases and multiparous group containing 6190 cases.Chi-square test was carried out to compare the rate of CD,neuraxial labor analgesia,maternity insurance between the two groups;1-test was performed to compare the in-hospital days and gestational age at birth between the two groups.Pearson corrclation coefficient was used to evaluate the rclationship among observed monthly rate of multiparas,overall CD rate,and Elective Repeat Cesarean Delivery(ERCD)rate.The results showed that the CD rate in multiparous group was 55.46%,which was higher than that in primiparous group(34.66%,P<0.05).The rate of neuraxial labor analgesia in multiparas group was 9.29%,which was lower than that in primiparas group(35.94%,P<0.05).However,the rate of maternity insurance was higher in multiparas group(57.00%)than that in primiparas group(41.08%,P<0.05).The hospital cost and in-hospital days in multiparas group were higher,and the gcstational age at birth in multiparas group was lower than in primiparas group(P<0.05).The overall CD rate slightly dropped in the first 4 months of the year(P<0.05),then increased from 36.27%(April)to 43.21%(Dcember)(P<0.05).The rate of multiparas women and ERCD had the same trend(P<0.05).There were linear correlations among the rate of overall CD,the rate of multiparas women and the rate of ERCD rate(P<0.05).With the opening of 展开更多
关键词 cesarean delivery elective repeat cesarean delivery Trial of Labor After Cesarean Section(TOLAC)
在线阅读 下载PDF
Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems 认领
7
作者 Kanghee Jo Hyeongmin Kim +4 位作者 Prakash Khadka Taejun Jang Soo Jin Kim Seong-Ha Hwang Jaehwi Lee 《亚洲药物制剂科学(英文)》 SCIE CAS 2020年第3期336-346,共11页
The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. ... The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated selfmicroemulsifying drug delivery system(S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the drug precipitation to enhance the lymphatic transport of saquinavir and to increase the bioavailability of saquinavir considerably. Solubilizing capacity of different oils, surfactants, and cosurfactants for saquinavir was evaluated to select optimal ingredients for preparation of SMEDDS.Through the construction of pseudo-ternary phase diagram, SMEDDS formulations were established. A polymer as a precipitation inhibitor was selected based on its viscosity and drug precipitation inhibiting capacity. The S-SMEDDS and SMEDDS designed were administered at an equal dose to rats. At predetermined time points, levels of saquinavir in lymph collected from the rats were assessed. SMEDDS prepared presented a proper selfmicroemulsification efficiency and dispersion stability. The S-SMEDDS fabricated using the SMEDDS and hydroxypropyl methyl cellulose 2910 as a precipitation inhibitor exhibited a signficantly enhanced solubilizing capacity for saquinavir. The drug concentration in a simulated intestinal fluid evaluated with the S-SMEDDS was also maintained at higher levels for prolonged time than that examined with the SMEDDS. The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the SMEDDS.Therefore, the S-SMEDDS would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatic system. 展开更多
关键词 Lymphatic drug delivery Self-microemulsifying drug delivery system SAQUINAVIR Precipitation inhibitor SUPERSATURATION Lipid-based formulation
在线阅读 下载PDF
Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy 认领
8
作者 Xuanfang Zhou Zhouqi Meng +10 位作者 Jialin She Yaojia Zhang Xuan Yi Hailin Zhou Jing Zhong Ziliang Dong Xiao Han Muchao Chen Qin Fan Kai Yang Chao Wang 《纳微快报:英文版》 SCIE EI CAS CSCD 2020年第8期116-129,共14页
Radiotherapy(RT)is a widely used way for cancer treatment.However,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so on.Nitric oxide(NO)is known a v... Radiotherapy(RT)is a widely used way for cancer treatment.However,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so on.Nitric oxide(NO)is known a very effective radiosensitizer of hypoxic tumor.However,NO cannot circulate in body with high concentration.Herein,an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy.Tert-Butyl nitrite,which is an efficient NO source,is coupled to Ag2S quantum dots(QDs).NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect.In addition,Ag is also a type of heavy metal that can benefit the RT therapy.We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model.Furthermore,immunosuppressive tumor microenvironment is improved by our NO delivery system,significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy.100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms.Our results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy. 展开更多
关键词 NO delivery Radio sensitivity Multifunctional agent RADIOIMMUNOTHERAPY Drug delivery
在线阅读 免费下载
微量镇痛泵在分娩镇痛中的应用效果分析 认领
9
作者 张丽莉 《中国医疗器械信息》 2020年第4期164-164,190共2页
目的:分析微量镇痛泵在分娩镇痛中的应用效果。方法:选取本院2017年12月~2019年5月接收的86例产妇作为研究对象,所有产妇均采用阴道分娩方式,将其基于奇偶顺序平均分为对照组和试验组,每组43例患者,对照组产妇在分娩过程中不采取任何镇... 目的:分析微量镇痛泵在分娩镇痛中的应用效果。方法:选取本院2017年12月~2019年5月接收的86例产妇作为研究对象,所有产妇均采用阴道分娩方式,将其基于奇偶顺序平均分为对照组和试验组,每组43例患者,对照组产妇在分娩过程中不采取任何镇痛措施,进行常规分娩,试验组产妇在分娩过程中采用微量镇痛泵进行镇痛,观察两组产妇在分娩过程中的疼痛情况以及顺利生产率。结果:试验组患者中完全无痛患者24例(55.82%)、微痛患者15例(34.88%)、疼痛患者4例(9.30%),对照组患者中完全无痛患者0例(0.00%)、微痛患者3例(6.98%)、疼痛患者40例(93.02%),组间差异具有统计学意义(P<0.05)。试验组产妇的顺利生产率为97.67%(42/43),高于对照组产妇的86.05%(37/43),差异具有统计学意义(P<0.05)。结论:采用微量镇痛泵在产妇分娩过程中进行镇痛可以起到有效缓解疼痛的效果,同时有助于提高顺利生产率。 展开更多
关键词 微量镇痛泵 分娩 顺利生产
在线阅读 免费下载
Progress in transdermal drug delivery systems for cancer therapy 认领
10
作者 Tianyue Jiang Guo Xu +3 位作者 Guojun Chen Yu Zheng Bingfang He Zhen Gu 《纳米研究:英文版》 SCIE EI CAS CSCD 2020年第7期1810-1824,共15页
Transdermal drug delivery is an appealing option except for oral and hypodermic administration.With the advancement of skin penetration strategies,various anticancer therapeutics ranging from liphilic small-molecule d... Transdermal drug delivery is an appealing option except for oral and hypodermic administration.With the advancement of skin penetration strategies,various anticancer therapeutics ranging from liphilic small-molecule drugs to hydrophilic biomacromolecules,can be administered transdermally,offering an optional regimen to treat skin cancers.In addition,the activation of the skin immune systems can also assist the treatment of distal sites.Current approaches on enhancing the transdermal delivery efficacy of anticancer drugs are summarized in this review.We also survey recent advances in micro-and nanotechnology-based transdermal formulations for cancer treatment,such as chemotherapy,gene therapy,immunotherapy,phototherapy and combination therapy.New penetration enhancers,materials,formulations and their hypothesized mechanisms for transdermal delivery are highlighted.Advantages and limitations regarding the state-of-the-art transdermal delivery technologies,as well as future perspective are also discussed. 展开更多
关键词 drug delivery tran sdermal delivery can cer therapy CHEMOTHERAPY imm un otherapy combi nation therapy
文章速递Strategies for Precise Engineering and Conjugation of Antibody Targeted-nanoparticles for Cancer Therapy 认领
11
作者 Yuan-yuan GUO Lu HUANG +1 位作者 Zhi-ping ZHANG De-hao FU 《当代医学科学(英文)》 SCIE CAS 2020年第3期463-473,共11页
Improvements in the diagnosis and treatment of cancer are urgently needed for use in nanotechnology.Nanoparticles(NPs)can reduce the side effects of traditional chemotherapy by sustained release of loaded drugs and in... Improvements in the diagnosis and treatment of cancer are urgently needed for use in nanotechnology.Nanoparticles(NPs)can reduce the side effects of traditional chemotherapy by sustained release of loaded drugs and increase therapeutic efficiency.NPs can also enhance endothelial permeation retention by size effect and its accumulation in tumor cells through passive targeting.Furthermore,it is critical to treat cancer with a controlled targeted drug which can be specifically delivered into tumor cells and released there,resulting in a targeted therapy to eradicate tumor cells while sparing normal cells.To this end,antibody-mediated targeting therapy has been developed,but imperfections in antibodies(Abs)limit this therapy.Therefore,the combination of NPs and Abs has been highly valued in recent years,because conjugating special Abs on the surface of NPs can increase targeting efficiency,enabling selective delivery of anti-cancer drugs to tumor cells.In this mini-review,we would like to enumerate the strategies for the conjugation of Abs to the surface of the NPs as well as the precise engineering of targeted NPs.The application of targeting antibody fragments in this drug delivery system will also be discussed. 展开更多
关键词 cancer drug delivery nanoparticle antibody conjugation
在线阅读 下载PDF
CO as a therapeutic agent: discovery and delivery forms 认领
12
作者 YANG Xiao-Xiao KE Bo-Wen +1 位作者 LU Wen WANG Bing-He 《中国天然药物:英文版》 SCIE CAS CSCD 2020年第4期284-295,共12页
Carbon monoxide(CO) as one of the three important endogenously produced signaling molecules, termed as "gasotransmitter," has emerged as a promising therapeutic agent for treating various inflammation and ce... Carbon monoxide(CO) as one of the three important endogenously produced signaling molecules, termed as "gasotransmitter," has emerged as a promising therapeutic agent for treating various inflammation and cellular-stress related diseases. In this review, we discussed CO’s evolution from a well-recognized toxic gas to a signaling molecule, and the effort to develop different approaches to deliver it for therapeutic application. We also summarize recently reported chemistry towards different CO delivery forms. 展开更多
关键词 Carbon monoxide Gasotransmitter CO delivery CO-RMs Organic CO prodrug
A Self-assembled Nanoparticle Platform Based on Amphiphilic Oleanolic Acid Polyprodrug for Cancer Therapy 认领
13
作者 Ying-Sa Wang Gui-Liang Li +5 位作者 Shang-Bin Zhu Fan-Chen Jing Run-Dong Liu Sai-Sai Li Jing He Jian-Du Lei 《高分子科学:英文版》 SCIE CAS CSCD 2020年第8期819-829,I0006,共12页
Oleanolic acid(OA)is a pentacyclic triterpenoid compound with extensive biological effects,such as anti-inflammatory and anticancer activities.However,the application of OA in chemotherapy is hampered by its poor solu... Oleanolic acid(OA)is a pentacyclic triterpenoid compound with extensive biological effects,such as anti-inflammatory and anticancer activities.However,the application of OA in chemotherapy is hampered by its poor solubility and severe adverse effects.To solve the problems,we developed a self-assembled nanoparticle platform based on amphiphilic oleanolic acid polyprodrug,poly[oligo(ethylene glycol)methyl ether methacrylate]-b-poly(oleanolic acid methacrylate)(POEGMA-b-POAMA),encapsulating 10-hydroxycamptothecin(HCPT)to achieve efficient cancer therapy.The polyprodrug was prepared via reversible addition-fragmentation chain transfer polymerization(RAFT),and could selfassemble to prepare POEGMA-b-POAMA/HCPT nanoparticles(NPs).The obtained nanoparticles exhibited appropriate particle size,excellent drug stability,good drug loading capacity,and high drug loading efficiency.In vitro drug release indicated that the drug release was prolonged to 132 h.The POEGMA-b-POAMA/HCPT NPs enhanced cell cytotoxicity in 4T1 cells and MCF-7 cells and could be efficiently uptaken by 4T1 cells.Furthermore,in vivo antitumor efficiency showed that the POEGMA-b-POAMA/HCPT NPs had great antitumor efficiency with considerably low adverse effects in the treatment of the 4T1 mouse breast tumor xenograft tumor.Therefore,POEGMA-b-POAMA/HCPT NPs provide great potential as a platform for drug delivery applications. 展开更多
关键词 SELF-ASSEMBLE NANOPARTICLE Oleanolic acid Amphiphilic polyprodrug Drug delivery
孕产妇胎膜早破合并生殖道感染对妊娠结局的影响 认领
14
作者 刘林 王兰云 +1 位作者 曹娟 叶国柳 《医学理论与实践》 2020年第17期2802-2804,共3页
目的:探讨胎膜早破合并生殖道感染对妊娠结局的影响。方法:收集2018年1月—2019年12月本院产科收治的120例确诊为胎膜早破(实验组)和60例非胎膜早破(对照组)孕妇的临床资料,观察两组孕妇生殖道感染情况以及对孕妇分娩方式和妊娠结局的... 目的:探讨胎膜早破合并生殖道感染对妊娠结局的影响。方法:收集2018年1月—2019年12月本院产科收治的120例确诊为胎膜早破(实验组)和60例非胎膜早破(对照组)孕妇的临床资料,观察两组孕妇生殖道感染情况以及对孕妇分娩方式和妊娠结局的影响。结果:实验组合并生殖道感染的阳性率(65.83%)明显高于对照组(18.33%),差异具有显著统计学意义(P<0.001);实验组合并生殖道感染造成自然分娩的比例明显低于对照组,而剖宫产率和阴道助产率均高于对照组,同时导致母体胎盘早剥、产褥感染、产后出血和绒毛膜羊膜炎等并发症发生率明显高于对照组,差异均具有显著的统计学意义(P<0.05);实验组合并生殖道感染可导致早产、新生儿呼吸窘迫综合征(ARDS)、新生儿窒息以及新生儿感染比例增加,并且除ARDS外增加幅度具有显著统计学意义(P<0.05)。结论:胎膜早破合并生殖道感染可显著影响孕妇分娩方式以及妊娠结局,应采取积极的治疗措施并加强护理观察。 展开更多
关键词 胎膜早破 生殖道感染 剖宫产 分娩
在线阅读 免费下载
自由体位分娩对其结局及盆底功能影响的研究 认领
15
作者 邱燕燕 仇春波 +2 位作者 任雪琼 金嫔嫔 徐芳 《中国妇幼健康研究》 2020年第6期800-804,共5页
目的探讨产妇自由体位分娩对分娩结局及产后盆底功能的影响。方法采用前瞻性随机对照临床试验方法,选取2017年12月至2018年12月在宁波大学医学院附属医院分娩中心自然分娩产妇250例,随机分为观察组125例行自由体位分娩,对照组125例行平... 目的探讨产妇自由体位分娩对分娩结局及产后盆底功能的影响。方法采用前瞻性随机对照临床试验方法,选取2017年12月至2018年12月在宁波大学医学院附属医院分娩中心自然分娩产妇250例,随机分为观察组125例行自由体位分娩,对照组125例行平卧体位分娩,对两组的分娩结局及产后盆底肌纤维肌力进行统计分析。结果两组分娩方式分布差异有统计学意义(χ^2=30.43,P<0.05)。在初产妇中,观察组的第一产程、第二产程及总产程均低于对照组,差异均有统计学意义(t值分别为-4.69、-4.59、-5.01,均P<0.05)。两组产妇分娩后出血量比较差异无统计学意义(t=-0.74,P=0.46)。两组产妇分娩后盆底Ⅰ类各级肌纤维肌力分布比较差异有统计学意义(χ^2=12.73,P<0.05);两组产妇分娩后Ⅰ、Ⅱ类盆底肌纤维肌力下降分布比较差异均有统计学意义(χ^2值分别为9.33、7.67,均P<0.05),在初产妇中,对照组Ⅰ、Ⅱ类盆底肌纤维肌力下降发生率均高于观察组,经比较差异均有统计学意义(χ^2值分别为6.13、5.03,均P<0.05)。结论实施自由体位分娩可显著降低剖宫产率及初产妇产程耗时,且盆底肌纤维肌力恢复好于平卧体位分娩。 展开更多
关键词 自由体位 平卧体位 分娩 结局 盆底肌纤维肌力
在线阅读 免费下载
罗哌卡因-芬太尼脉冲式自控硬膜外泵镇痛在初产妇分娩中的应用效果 认领
16
作者 郭迎霞 袁爱武 +1 位作者 胡祥明 屈华 《中国当代医药》 2020年第6期123-125,130共4页
目的探讨罗哌卡因-芬太尼脉冲式自控硬膜外泵镇痛在初产妇分娩中的应用效果。方法选取2017年8月~2018年4月我院收治的120例足月初产妇作为研究对象,根据随机数字表法分为观察组和对照组,每组各60例。观察组采用脉冲式自控硬膜外泵镇痛,... 目的探讨罗哌卡因-芬太尼脉冲式自控硬膜外泵镇痛在初产妇分娩中的应用效果。方法选取2017年8月~2018年4月我院收治的120例足月初产妇作为研究对象,根据随机数字表法分为观察组和对照组,每组各60例。观察组采用脉冲式自控硬膜外泵镇痛,对照组采用持续硬膜外阻滞泵镇痛。比较两组初产妇的第一产程时间、第二产程时间、罗哌卡因和芬太尼用量及脐血罗哌卡因浓度、第二产程时视觉模拟量表(VAS)评分、Bromage评分、满意度评分、催产素使用率、自然分娩率、新生儿Apgar评分及不良反应总发生率等情况。结果观察组产妇的第一、二产程时间短于对照组,罗哌卡因及芬太尼用量少于对照组,差异均有统计学意义(P<0.05);两组的脐血罗哌卡因浓度比较,差异无统计学意义(P>0.05);观察组产妇第二产程时VAS评分、Bromage评分及催产素使用率均低于对照组,差异有统计学意义(P<0.05);观察组产妇的满意度评分高于对照组,差异有统计学意义(P<0.05);观察组的自然分娩率高于对照组,差异有统计学意义(P<0.05);两组的新生儿Apgar评分及胎心率比较,差异无统计学意义(P>0.05);两组产妇的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论罗哌卡因-芬太尼脉冲式自控硬膜外泵对初产妇的镇痛效果更为显著。 展开更多
关键词 罗哌卡因 芬太尼 硬膜外阻滞 分娩 镇痛 初产妇
在线阅读 下载PDF
Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy 认领
17
作者 Jing Gao Wei-qi Wang +2 位作者 Qing Pei Megan SLord Hai-jun Yu 《中国药理学报:英文版》 SCIE CAS CSCD 2020年第7期986-994,共9页
Current cancer immunotherapy has limited response rates in a large variety of solid tumors partly due to the low immunogenicity of the tumor cells and the immunosuppressive tumor microenvironment(ITM).A number of clin... Current cancer immunotherapy has limited response rates in a large variety of solid tumors partly due to the low immunogenicity of the tumor cells and the immunosuppressive tumor microenvironment(ITM).A number of clinical cancer treatment modalities,including radiotherapy,chemotherapy,photothermal and photodynamic therapy,have been shown to elicit immunogenicity by inducing immunogenic cell death(ICD).However,ICD-based immunotherapy is restricted by the ITM limiting its efficacy in eliciting a long-term antitumor immune response,and by severe systemic toxicity.To address these challenges,nanomedicine-based drug delivery strategies have been exploited for improving cancer immunotherapy by boosting ICD of the tumor cells.Nanosized drug delivery systems are promising for increasing drug accumulation at the tumor site and codelivering ICD inducers and immune inhibitors to simultaneously elicit the immune response and relieve the ITM.This review highlights the recent advances in nanomedicine-based immunotherapy utilizing ICD-based approaches.A perspective on the clinical translation of nanomedicine-based cancer immunotherapy is also provided. 展开更多
关键词 cancer immunotherapy immunogenic cell death immunosuppressive tumor microenvironment NANOMEDICINE drug delivery systems
Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery 认领
18
作者 Yalei Miao Yudian Qiu +6 位作者 Mengna Zhang Ke Yan Panke Zhang Siyu Lu Zhongyi Liu Xiaojing Shi Xubo Zhao 《纳微快报:英文版》 SCIE EI CAS CSCD 2020年第9期324-338,共15页
Molecular self-assembly is crucially fundamental to nature.However,the aqueous self-assembly of polymers is still a challenge.To achieve self-assembly of block copolymers [(polyacrylic acid-block-polyethylene glycol-b... Molecular self-assembly is crucially fundamental to nature.However,the aqueous self-assembly of polymers is still a challenge.To achieve self-assembly of block copolymers [(polyacrylic acid-block-polyethylene glycol-block-polyacrylic acid(PAA68-b-PEG86-b-PAA68)] in an aqueous phase,manganese oxide(MnO2) is first generated to drive phase separation of the PAA block to form the PAA68-b-PEG68-b-PAA68/MnO2 polymeric assembly that exhibits a stable structure in a physiological medium.The polymeric assembly exhibits vesicular morphology with a diameter of approximately 30 nm and high doxorubicin(DOX) loading capacity of approximately 94%.The transformation from MnO2 to Mn2+caused by endogenous glutathione(GSH)facilitates the disassembly of PAA68-b-PEG68-b-PAA68/MnO2 to enable its drug delivery at the tumor sites.The toxicity of DOXloaded PAA68-b-PEG68-b-PAA69/MnO2 to tumor cells has been verified in vitro and in vivo.Notably,drug-loaded polymeric vesicles have been demonstrated,especially in in vivo studies,to overcome the cardiotoxicity of DOX.We expect this work to encourage the potential application of polymer self-assembly. 展开更多
关键词 POLYMER Aqueous self-assembly Vesicles Tumor microenvironment Drug delivery system
在线阅读 免费下载
Retrievable puncture anchor traction method for endoscopic ultrasound-guided gastroenterostomy: A porcine study 认领
19
作者 Guo-Xin Wang Kai Zhang Si-Yu Sun 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第25期3603-3610,共8页
BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)is an alternative method for the surgical treatment of gastric outlet obstruction,but it is regarded as a challenging technique for endoscopists as the ... BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)is an alternative method for the surgical treatment of gastric outlet obstruction,but it is regarded as a challenging technique for endoscopists as the bowel is highly mobile and can tent away.Thus,the technique requires superb skill.In order to improve EUS-GE,we have developed a retrievable puncture anchor traction(RPAT)device for EUSGE to address the issue of bowel tenting.AIM To evaluate the feasibility of RPAT-assisted EUS-GE using an animal model.METHODS Six Bama mini pigs each weighing between 15 and 20 kg underwent the RPATassisted EUS-GE procedure.Care was taken to ensure that the animals experienced minimal pain and discomfort.Two days prior to the procedure the animals were limited to a liquid diet.No oral intake was allowed on the day before the procedure.A fully covered metal stent was placed between the stomach and the intestine using the RPAT-assisted EUS-GE method.Infection in the animals was determined.Four weeks after the procedure,a standard gastroscope was inserted into the pig’s intestine through a previously created fistula in order to check the status of the stents under anesthesia.The pig was euthanized after examination.RESULTS The RPAT-assisted EUS-GE method allowed placement of the stents with no complications in all six animals.All the pigs tolerated a regular diet within hours of the procedure.The animals were monitored for four weeks after the RPATassisted EUS-GE,during which time all of the animals exhibited normal eating behavior and no signs of infection were observed.Endoscopic imaging performed four weeks after the RPAT-assisted EUS-GE showed that the stents remained patent and stable in all the animals.No tissue overgrowth or ingrowth was observed in any case.Each animal had a mature fistula,and the stents were removed without significant bleeding.Autopsies of all six pigs revealed complete adhesion between the intestine and the stomach wall.CONCLUSION The RPAT method helps reduce mobility of the bowel.Therefore, 展开更多
关键词 Retrievable puncture anchor Endoscopic ultrasound Endoscopic ultrasoundguided gastroenterostomy Gastric outlet obstruction GASTROENTEROSTOMY Electrocauteryenhanced delivery of lumen-apposing metal stents
在线阅读 免费下载
Hemodynamic characteristics in preeclampsia women during cesarean delivery after spinal anesthesia with ropivacaine 认领
20
作者 Na Zhao Jin Xu +5 位作者 Xiao-Guang Li Joseph Harold Walline Yi-Chong Li Lin Wang Guo-Sheng Zhao Ming-Jun Xu 《世界临床病例杂志》 SCIE 2020年第8期1444-1453,共10页
BACKGROUND Very few studies have been published on the hemodynamic changes associated with spinal anesthesia induced with ropivacaine during cesarean deliveries in preeclamptic women.AIM To record and analyze hemodyna... BACKGROUND Very few studies have been published on the hemodynamic changes associated with spinal anesthesia induced with ropivacaine during cesarean deliveries in preeclamptic women.AIM To record and analyze hemodynamic data in women with preeclampsia undergoing cesarean delivery after spinal anesthesia induced with ropivacaine.METHODS Ten eligible women with preeclampsia were enrolled in this prospective observational study.Spinal anesthesia was performed with 2.4 mL of 0.5%ropivacaine.Hemodynamic changes were then analyzed at multiple time points.The hemodynamic responses to vasopressor interventions and uterotonic agents,as well as maternal and neonatal outcomes were also recorded.RESULTS Stable hemodynamic trends were observed in this study.Cardiac output(CO)and stroke volume increased mildly during surgery.In contrast,mean arterial pressure and systemic vascular resistance showed a moderate decrease from induction until the end of surgery.Central venous pressure dramatically increased after delivery.Oxytocin administration was associated with the most significant hemodynamic fluctuations during surgery,namely,an increase in CO and heart rate.Phenylephrine intervention was only required in three patients,and caused an increase in mean arterial pressure and systemic vascular resistance along with a decrease in heart rate,stroke volume,and CO.No maternal and neonatal complications were observed during this study,except transient episodes of hypotension.CONCLUSION Spinal anesthesia for caesarian delivery with ropivacaine in women with preeclampsia is linked to modest hemodynamic changes of no clinical significance in this study.Careful cardiovascular monitoring is still recommended,particularly after the delivery of the fetus or the use of oxytocin. 展开更多
关键词 PREECLAMPSIA CESAREAN delivery Spinal ANESTHESIA Cardiac output HEMODYNAMICS
在线阅读 免费下载
上一页 1 2 250 下一页 到第
使用帮助 返回顶部 意见反馈