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Comparing different domains of analysis for the characterisation of N-glycans on monoclonal antibodies 预览
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作者 Sara Carillo Raquel Peerez-Robles +5 位作者 Craig Jakes Meire Ribeiro da Silva Silvia Millan Martín Amy Farrell Natalia Navas Jonathan Bones 《药物分析学报:英文版》 CAS CSCD 2020年第1期23-34,共12页
With the size of the biopharmaceutical market exponentially increasing,there is an aligned growth in the importance of data-rich analyses,not only to assess drug product safety but also to assist drug development driv... With the size of the biopharmaceutical market exponentially increasing,there is an aligned growth in the importance of data-rich analyses,not only to assess drug product safety but also to assist drug development driven by the deeper understanding of structure/function relationships.In monoclonal antibodies,many functions are regulated by N-glycans present in the constant region of the heavy chains and their mechanisms of action are not completely known.The importance of their function focuses analytical research efforts on the development of robust,accurate and fast methods to support drug development and quality control.Released N-glycan analysis is considered as the gold standard for glycosylation characterisation;however,it is not the only method for quantitative analysis of glycoform heterogeneity.In this study,ten different analytical workflows for N-glycan analysis were compared using four monoclonal antibodies.While observing good comparability between the quantitative results generated,it was possible to appreciate the advantages and disadvantages of each technique and to summarise all the observations to guide the choice of the most appropriate analytical workflow according to application and the desired depth of data generated. 展开更多
关键词 N-GLYCANS BIOPHARMACEUTICALS Monoclonal antibodies Intact mass analysis Mass spectrometry Native mass spectrometry Glycan analysis Peptide mapping Glycopeptide analysis
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Evaluation of Temporal Changes in Deep Well Water Quality in Igabi Local Government Area of Kaduna State 预览
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作者 John Jiya Musa Otuaro Ebierni Akpoebidimiyen +2 位作者 Mohammed Tanimu Musa Pius Olusegun Olufemi Dada Elijah Tsado Musa 《环境保护(英文)》 2020年第1期22-33,共12页
The research work was carried out in Igabi Local Government of Kaduna State. Thirty water samples from boreholes were randomly collected within the major towns in November to April (Dry), and May to October (Rainy sea... The research work was carried out in Igabi Local Government of Kaduna State. Thirty water samples from boreholes were randomly collected within the major towns in November to April (Dry), and May to October (Rainy season). The samples were analyzed for physical, chemical, and bacteriological parameters and to observe any changes in the groundwater quality of the area. Analysis of variance (ANOVA), Pearson Correlation were performed on the data obtained using SPSS 10.0 for a window for significant variations and inter-element relationship. High mean turbidity was recorded in boreholes in Danfili (12.2 NTU), Kwarau (6.2 NTU). Mean turbidity of 4.3 NTU was recorded in Dry season for wells with Rigachikun having 5.1 NTU. It was observed that a negative correlation exists between well depth and heavy metal concentration. There was also a linear relationship of 0.686 between well distance and nitrate (faecal contaminant). Mean value for Fluoride (0.22 mg/l), Sodium (20.78 mg/l), Calcium (15.7 mg/l), Iron (0.013 mg/l), Nitrate (3.69 mg/l), Cadmium (0.00102 mg/l) Chloride (22.107 mg/l) recorded for sampled wells were all within WHO standard. A high value of 24 mg/l and 25 mg/l for Nitrate was recorded in Saminaka Road and Danfili. An indication of contamination during the rainy season indicates surface-groundwater intrusion (influx). The results of the bacteriological analysis indicated that most wells sampled have a range of 1 cfu/100 ml to 7 cfu/100 ml with Danfili Mani having the highest value (7 cfu/100 ml) which make it unsaved (not Potable). 展开更多
关键词 TEMPORAL CHANGE Analysis GROUNDWATER Physiochemical Bacteriological Quality
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Estimation of drift limits for different seismic damage states of RC frame staging in elevated water tanks using Park and Ang damage index 预览
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作者 Suraj O.Lakhade Ratnesh Kumar O.R.Jaiswal 《地震工程与工程振动:英文版》 SCIE EI CSCD 2020年第1期161-177,共17页
Damage to elevated water tanks in past earthquakes can be attributed to the poor performance of their supporting frame staging. In order to ascertain the performance of these elevated water tanks, it is crucial to cat... Damage to elevated water tanks in past earthquakes can be attributed to the poor performance of their supporting frame staging. In order to ascertain the performance of these elevated water tanks, it is crucial to categorize the damage in quantifiable damage states. Among various parameters to quantify the damage states, the top drift of frame staging can be conveniently correlated to the different damage levels. In literature, drift limits corresponding to different damage states of the frame staging of the elevated water tank are not available. In the present study, drift limits for RC frame staging in elevated water tanks corresponding to different seismic damage states have been proposed. Various damage states of the elevated water tank have been determined using the Park and Ang damage index. The Park and Ang damage index utilizes results of both pushover analysis and incremental dynamic analysis. Twelve models of elevated water tanks have been developed considering variation in staging height and tank capacity. Incremental dynamic analysis has been performed using the suite of twelve actual earthquake ground motions. Based on the regression analysis between damage indexes and drift, limiting drift values for each damage state are proposed. 展开更多
关键词 elevated water tank frame staging damage states drift limit 3D modelling incremental dynamic analysis pushover analysis
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Seismic and stress qualification of LMFR fuel rod and simple method for the determination of LBE added mass effect 预览
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作者 M.Khizer Jian-Wei Chen +3 位作者 Guo-Wei Yang Qing-Sheng Wu Yong Song Yong Zhang 《核技术:英文版》 SCIE CAS CSCD 2020年第1期42-56,共15页
In this study, two different designs of liquid metal fast reactor(LMFR) fuel rods wire-wrapped and nonwire-wrapped(bare) are compared with respect to different parameters as a means of considering the optimum fuel des... In this study, two different designs of liquid metal fast reactor(LMFR) fuel rods wire-wrapped and nonwire-wrapped(bare) are compared with respect to different parameters as a means of considering the optimum fuel design. Nuclear seismic rules require that systems and components that are important for safety must be capable of bearing earthquake effects, and that their integrity and functionality should be guaranteed. Mode shapes, natural frequencies, stresses on cladding, and seismic aspects are considered for comparison using ANSYS. Modal analysis is compared in a vacuum and in lead–bismuth eutectic(LBE) using potential flow theory by considering the added mass effect. A simple and accurate approach is suggested for the determination of the LBE added mass effect and is verified by a manually calculated added mass, which further proved the usefulness of potential flow theory for the accurate estimation of the added mass effect. The verification of the hydrodynamic function(τ) over the entire frequency range further validated the finite element method(FEM) modal analysis results. Stresses obtained for fuel rods against different loading combinations revealed that they were within the allowable limits with maximum stress ratios of 0.25(bare) and 0.74(wire-wrapped). In order to verify the structural integrity of cladding tubes, stresses along the cladding length were determined during different transients and were also calculated manually for static pressure. The manual calculations could be roughly compared with the ANSYS results, and the two showed a close agreement. Contact analysis methodology was selected,and the most appropriate analysis options were suggested for establishing contact between the wire and cladding for the wire-wrapped design grid independence analysis,which proved the accuracy of the results, confirmed the selection of the appropriate procedure, and validated the use of the ANSYS mechanical APDL code for LMFR fuel rod analysis. The results provided detailed insight into the structural desi 展开更多
关键词 LMFR Fuel rod Added mass Seismic analysis Contact analysis
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Single-nucleotide polymorphism screening and RNA sequencing of key messenger RNAs associated with neonatal hypoxic-ischemia brain damage 预览
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作者 Liu-Lin Xiong Lu-Lu Xue +7 位作者 Mohammed Al-Hawwas Jin Huang Rui-Ze Niu Ya-Xin Tan Yang Xu Ying-Ying Su Jia Liu Ting-Hua Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期86-95,共10页
A single-nucleotide polymorphism(SNP)is an alteration in one nucleotide in a certain position within a genome.SNPs are associated with disease susceptibility.However,the influences of SNPs on the pathogenesis of neona... A single-nucleotide polymorphism(SNP)is an alteration in one nucleotide in a certain position within a genome.SNPs are associated with disease susceptibility.However,the influences of SNPs on the pathogenesis of neonatal hypoxic-ischemic brain damage remain elusive.Seven-day-old rats were used to establish a hypoxic ischemic encephalopathy model.SNPs and expression profiles of mRNAs were analyzed in hypoxic ischemic encephalopathy model rats using RNA sequencing.Genes exhibiting SNPs associated with hypoxic ischemic encephalopathy were identified and studied by gene ontology and pathway analysis to identify their possible involvement in the disease mechanism.We identified 89 up-regulated genes containing SNPs that were mainly located on chromosome 1 and 2.Gene ontology analysis indicated that the up-regulated genes containing SNPs are mainly involved in angiogenesis,wound healing and glutamatergic synapse and biological processing of calcium-activated chloride channels.Signaling pathway analysis indicated that the differentially expressed genes play a role in glutamatergic synapses,long-term depression and oxytocin signaling.Moreover,intersection analysis of high throughput screening following PubMed retrieval and RNA sequencing for SNPs showed that CSRNP1,DUSP5 and LRRC25 were most relevant to hypoxic ischemic encephalopathy.Significant up-regulation of genes was confirmed by quantitative real-time polymerase chain reaction analysis of oxygen-glucose-deprived human fetal cortical neurons.Our results indicate that CSRNP1,DUSP5 and LRRC25,containing SNPs,may be involved in the pathogenesis of hypoxic ischemic encephalopathy.These findings indicate a novel direction for further hypoxic ischemic encephalopathy research.This animal study was approved on February 5,2017 by the Animal Care and Use Committee of Kunming Medical University,Yunnan Province,China(approval No.kmmu2019038).Cerebral tissue collection from a human fetus was approved on September 30,2015 by the Ethics Committee of Kunming Medical University,Chin 展开更多
关键词 CSRNP1 DUSP5 gene ontology ANALYSIS human FETAL CORTICAL neurons LRRC25 mRNA NEONATAL HYPOXIC ischemic ENCEPHALOPATHY pathogenesis signaling pathway ANALYSIS
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Effects of Tidal Channels and Roads on Landscape Dynamic Distribution in the Yellow River Delta,China 预览
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作者 YU Xiaojuan ZHANG Zhongsheng +2 位作者 XUE Zhenshan WU Haitao ZHANG Hongri 《中国地理科学:英文版》 SCIE CSCD 2020年第1期170-179,共10页
Landscape characters in estuarine regions generally controlled by tidal regimes and human activities like road construction.In this work,tidal channels and road construction in the Yellow River Delta(YRD)were extracte... Landscape characters in estuarine regions generally controlled by tidal regimes and human activities like road construction.In this work,tidal channels and road construction in the Yellow River Delta(YRD)were extracted by visual interpretation methods so as to decipher impacts of tidal channel development and road construction on landscape patch change during 1989–2016.Spatial distribution history of three wetlands,which covered by Phragmites australis(freshwater marsh,FM),Suaeda salsa(salt marsh,SM),and mudflats(MD)were also established.Results indicated that tidal channel,number,frequency,and fractal dimension were all the maximum in 2003,and the minimum in 1998,respectively.Road length,number,and density showed increasing trend during 1989–2016.MD were the predominant landscape type,followed by FM and SM during 1989-2016.Principal component analysis implied two extracted factors,F1 and F2,which could represent 91.93% of the total variations.F1 mainly proxied tidal channel development,while F2 represented road construction.A multiple linear regression analysis showed positive effects of both F1 and F2 on FM patch numbers and negative impacts on SM patch areaes with R^2 values of 0.416 and 0.599,respectively.Tidal channels were negatively related to MD patch numbers,while roads were positively related to that.In any case,road construction showed larger impacts on landscape type shifting than that of tidal channel development in the YRD. 展开更多
关键词 tidal channel development road construction principal component analysis multiple linear regression analysis the Yellow River Delta
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The role of viscoelastic damping on retrofitting seismic performance of asymmetric reinforced concrete structures 预览
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作者 Zeshan Alam Chunwei Zhang Bijan Samali 《地震工程与工程振动:英文版》 SCIE EI CSCD 2020年第1期223-237,共15页
The primary purpose of this research is to improve the seismic response of a complex asymmetric tall structure using viscoelastic(VE) dampers. Asymmetric structures have detrimental effects on the seismic performance ... The primary purpose of this research is to improve the seismic response of a complex asymmetric tall structure using viscoelastic(VE) dampers. Asymmetric structures have detrimental effects on the seismic performance because such structures create abrupt changes in the stiffness or strength that may lead to undesirable stress concentrations at weak locations. Structural control devices are one of the effective ways to reduce seismic impacts, particularly in asymmetric structures. For passive vibration control of structures, VE dampers are considered among the most preferred devices for energy dissipation. Therefore, in this research, VE dampers are implemented at strategic locations in a realistic case study structure to increase the level of distributed damping without occupying significant architectural space and reducing earthquake vibrations in terms of story displacements(drifts) and other design forces. It has been concluded that the seismic response of the considered structure retrofitted with supplemental VE dampers corresponded well in controlling the displacement demands. Moreover, it has been demonstrated that seismic response in terms of interstory drifts was effectively mitigated with supplemental damping when added up to a certain level. Exceeding the supplemental damping from this level did not contribute to additional mitigation of the seismic response of the considered structure. In addition, it was found that the supplemental damping increased the total acceleration of the considered structure at all floor levels, which indicates that for irregular tall structures of this type, VE dampers were only a good retrofitting measure for earthquake induced interstory deformations and their use may not be suitable for acceleration sensitive structures. Overall, the research findings demonstrate how seismic hazards to these types of structures can be reduced by introducing additional damping into the structure. 展开更多
关键词 viscoelastic dampers seismic analysis asymmetric structure nonlinear modal time history analysis
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Biological characteristics of dynamic expression of nerve regeneration related growth factors in dorsal root ganglia after peripheral nerve injury 预览
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作者 Yin-Ying Shen Xiao-Kun Gu +3 位作者 Rui-Rui Zhang Tian-Mei Qian Shi-Ying Li Sheng Yi 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第8期1502-1509,共8页
The regenerative capacity of peripheral nerves is limited after nerve injury.A number of growth factors modulate many cellular behaviors,such as proliferation and migration,and may contribute to nerve repair and regen... The regenerative capacity of peripheral nerves is limited after nerve injury.A number of growth factors modulate many cellular behaviors,such as proliferation and migration,and may contribute to nerve repair and regeneration.Our previous study observed the dynamic changes of genes in L4–6 dorsal root ganglion after rat sciatic nerve crush using transcriptome sequencing.Our current study focused on upstream growth factors and found that a total of 19 upstream growth factors were dysregulated in dorsal root ganglions at 3,9 hours,1,4,or 7 days after nerve crush,compared with the 0 hour control.Thirty-six rat models of sciatic nerve crush injury were prepared as described previously.Then,they were divided into six groups to measure the expression changes of representative genes at 0,3,9 hours,1,4 or 7 days post crush.Our current study measured the expression levels of representative upstream growth factors,including nerve growth factor,brain-derived neurotrophic factor,fibroblast growth factor 2 and amphiregulin genes,and explored critical signaling pathways and biological process through bioinformatic analysis.Our data revealed that many of these dysregulated upstream growth factors,including nerve growth factor,brain-derived neurotrophic factor,fibroblast growth factor 2 and amphiregulin,participated in tissue remodeling and axon growth-related biological processes Therefore,the experiment described the expression pattern of upstream growth factors in the dorsal root ganglia after peripheral nerve injury.Bioinformatic analysis revealed growth factors that may promote repair and regeneration of damaged peripheral nerves.All animal surgery procedures were performed in accordance with Institutional Animal Care Guidelines of Nantong University and ethically approved by the Administration Committee of Experimental Animals,China(approval No.20170302-017)on March 2,2017. 展开更多
关键词 axon growth bioinformatic analysis dorsal root ganglia growth factors Ingenuity Pathway Analysis nerve regeneration peripheral nerve injury rat sciatic nerve crush injury transcriptome sequencing upstream regulators
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尿毒症维持性血液透析患者发生腹主动脉钙化的危险因素分析
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作者 魏学婷 崔汉民 +3 位作者 丁宁 白久旭 武元赫 曹宁 《中国实用乡村医生杂志》 2020年第1期59-61,64,共4页
目的分析维持性血液透析治疗的尿毒症患者发生腹主动脉钙化的危险因素。方法选取20172018年在北部战区总医院血液净化中心进行维持性血液透析治疗的尿毒症患者112例,收集所有患者临床相关资料进行回顾性分析,同时依据是否有腹主动脉钙... 目的分析维持性血液透析治疗的尿毒症患者发生腹主动脉钙化的危险因素。方法选取20172018年在北部战区总医院血液净化中心进行维持性血液透析治疗的尿毒症患者112例,收集所有患者临床相关资料进行回顾性分析,同时依据是否有腹主动脉钙化分为钙化组(62例)和非钙化组(50例),试分析影响腹主动脉钙化发生的因素。结果钙化组年龄、透析龄、合并糖尿病例数、全段甲状旁腺激素、血磷、钙磷乘积水平与非钙化组差异均有统计学意义(P<0.05)。Logistic回归分析显示,年龄、合并糖尿病、钙磷乘积和全段甲状旁腺激素水平是维持性血液透析治疗尿毒症患者发生腹主动脉钙化的危险因素。结论对于高龄、合并糖尿病、高钙磷乘积和高全段甲状旁腺激素水平的维持性血液透析治疗尿毒症患者,应警惕其发生腹主动脉钙化的可能,应定期行相关实验室及腹主动脉钙化检测,以早发现早治疗腹主动脉钙化,提高维持性血液透析治疗尿毒症患者的生存质量及生存率。 展开更多
关键词 尿毒症 维持性血液透析 腹主动脉钙化 危险因素 分析
粗糙脉孢菌产纤维素酶活力条件分析 预览
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作者 李笑峰 张玲秀 赵二劳 《化工时刊》 CAS 2020年第1期19-21,41,共4页
为了获得廉价而高活力的纤维素酶用于实际生产,本试验以硫酸铵分级盐析、葡聚糖凝胶层析纯化的粗糙脉孢菌所产纤维素酶为试材,分析研究了温度、pH及几种金属离子对其活力的影响。结果表明,温度50℃、pH 4.8时,该纤维素酶活力最强。K+对... 为了获得廉价而高活力的纤维素酶用于实际生产,本试验以硫酸铵分级盐析、葡聚糖凝胶层析纯化的粗糙脉孢菌所产纤维素酶为试材,分析研究了温度、pH及几种金属离子对其活力的影响。结果表明,温度50℃、pH 4.8时,该纤维素酶活力最强。K+对纤维素酶活力具有激活作用,Zn 2+、Mg 2+和Cu 2+抑制纤维素酶活力。本研究为粗糙脉孢菌产纤维素酶的进一步研究和应用奠定了基础。 展开更多
关键词 粗糙脉孢菌 纤维素酶 活力 分析
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Identification of protein targets for the antidepressant effects of Kai-Xin-San in Chinese medicine using isobaric tags for relative and absolute quantitation 预览
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作者 Xian-Zhe Dong Dong-Xiao Wang +3 位作者 Tian-Yi Zhang Xu Liu Ping Liu Yuan Hu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期302-310,共9页
Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China. However, no studi... Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China. However, no studies have identified the key proteins implicated in response to Kai-Xin-San treatment. In this study, rat models of chronic mild stress were established using different stress methods over 28 days. After 14 days of stress stimulation, rats received daily intragastric administrations of 600 mg/kg Kai-Xin-San. The sucrose preference test was used to determine depression-like behavior in rats, while isobaric tags were used for relative and absolute quantitation-based proteomics to identify altered proteins following Kai-Xin-San treatment. Kai-Xin-San treatment for 2 weeks noticeably improved depression-like behaviors in rats with chronic mild stress. We identified 33 differentially expressed proteins: 7 were upregulated and 26 were downregulated. Functional analysis showed that these differentially expressed proteins participate in synaptic plasticity, neurodevelopment, and neurogenesis. Our results indicate that Kai-Xin-San has an important role in regulating the key node proteins in the synaptic signaling network, and are helpful to better understand the mechanism of the antidepressive effects of Kai-Xin-San and to provide objective theoretical support for its clinical application. The study was approved by the Ethics Committee for Animal Research from the Chinese PLA General Hospital(approval No. X5-2016-07) on March 5, 2016. 展开更多
关键词 BRAIN-DERIVED neurotrophic factor signal pathway depression ISOBARIC tags for RELATIVE and absolute quantitation Kai-Xin-San neurogenesis protein network proteomics analysis synaptic plasticity traditional Chinese medicine
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农村集体经济发展中经营内容和组织模式研究分析——以重庆市为例 预览
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作者 李晓波 樊莉 《安徽农业科学》 CAS 2020年第4期224-226,共3页
通过调查对重庆市16个区县195个自然村农村集体经济发展情况,对集体经济发展中的经营内容和组织模式对农村集体经济发展的影响进行总结、分类,对经营内容和组织模式进行方差分析,对组织模式与经营内容进行交互分析,认为经营内容和组织... 通过调查对重庆市16个区县195个自然村农村集体经济发展情况,对集体经济发展中的经营内容和组织模式对农村集体经济发展的影响进行总结、分类,对经营内容和组织模式进行方差分析,对组织模式与经营内容进行交互分析,认为经营内容和组织模式在农村集体经济发展中存在非常密切的相关性,对进一步研究农村集体经济,深化农村集体经济制度改革、激发农村集体经济的发展活力具有重要意义。 展开更多
关键词 农村集体经济 经营内容 组织模式 分析
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Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma 预览
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作者 Yan Cheng Mandy Pereira +10 位作者 Neha P.Raukar John L.Reagan Mathew Quesenberry Laura Goldberg Theodor Borgovan W Curt LaFrance Jr Mark Dooner Maria Deregibus Giovanni Camussi Bharat Ramratnam Peter Quesenberry 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期676-681,共6页
At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential bioma... At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI and evaluation of TBI severity.We hypothesize that the genetic profile of salivary extracellular vesicles in patients with head trauma differs from that in uninjured subjects.Findings from this hypothesis would help investigate the severity of TBI.This study included 19 subjects,consisting of seven healthy controls who denied history of head trauma,six patients diagnosed with concussion injury from an outpatient concussion clinic,and six patients with TBI who received treatment in the emergency department within 24 hours after injury.Real-time PCR analysis of salivary extracellular vesicles in participants was performed using TaqMan Human Inflammation array.Gene expression analysis revealed nine upregulated genes in emergency department patients(LOX5,ANXA3,CASP1,IL2RG,ITGAM,ITGB2,LTA4H,MAPK14,and TNFRSF1A)and 13 upregulated genes in concussion clinic patients compared with healthy participants(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,LTB4R2,LTB4R,PTAFR,CYSLTR1,CES1,KLK1,MC2R,and PTGER3).Each patient group had a unique profile.Comparison between groups showed that 15 inflammation-related genes had significant expression change.Our results indicate that inflammation biomarkers can be used for diagnosis of TBI and evaluation of disease severity.This study was approved by the Institutional Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16). 展开更多
关键词 chronic TRAUMATIC encephalopathy emergency department extracellular vesicles INFLAMMATION OUTPATIENT CONCUSSION clinic real-time PCR analysis SALIVA TRAUMATIC brain injury
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游梁抽油机井井下油水分离器设计及仿真分析 预览
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作者 董祥伟 张立军 +3 位作者 李增亮 张辛 刘延鑫 李风涛 《石油矿场机械》 2020年第1期20-26,共7页
针对游梁式抽油机井间隙供液的特点,设计了适用于139.7 mm(51/2英寸)套管的井下油水分离器,与游梁式抽油机配套使用,在井下完成油水分离、原油举升和采出水回注工艺。根据游梁抽油机的机构运动规律,推导得出了井下水力旋流器的入口流量... 针对游梁式抽油机井间隙供液的特点,设计了适用于139.7 mm(51/2英寸)套管的井下油水分离器,与游梁式抽油机配套使用,在井下完成油水分离、原油举升和采出水回注工艺。根据游梁抽油机的机构运动规律,推导得出了井下水力旋流器的入口流量波动曲线。将该曲线转换为流体仿真模型的瞬态入口边界条件,数值模拟得出了井下旋流器的三维瞬态流场分布,得到了底流含油浓度波动规律。 展开更多
关键词 游梁式抽油机 井下油水分离器 设计 分析
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Distribution of Bacterial Communities in Petroleum-Contaminated Soils from the Dagang Oilfi eld, China 预览
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作者 Xueke Feng Zhen Liu +1 位作者 Xiaoqiang Jia Wenyu Lu 《天津大学学报:英文版》 EI CAS 2020年第1期22-32,共11页
Diversity in bacterial communities was investigated along a petroleum hydrocarbon content gradient(0-0.4043 g/g)in surface(5-10 cm)and subsurface(35-40 cm)petroleum-contaminated soil samples from the Dagang Oilfield,C... Diversity in bacterial communities was investigated along a petroleum hydrocarbon content gradient(0-0.4043 g/g)in surface(5-10 cm)and subsurface(35-40 cm)petroleum-contaminated soil samples from the Dagang Oilfield,China.Using 16S rRNA Illumina high-throughput sequencing technology and several statistical methods,the bacterial diversity of the soil was studied.Subsequently,the environmental parameters were measured to analyze its relationship with the community variation.Nonmetric multidimensional scaling and analysis of similarities indicated a significant difference in the structure of the bacterial community between the nonpetroleum-contaminated surface and subsurface soils,but no differences were observed in different depths of petroleum-contaminated soil.Meanwhile,many significant correlations were obtained between diversity in soil bacterial community and physicochemical properties.Total petroleum hydrocarbon,total organic carbon,and total nitrogen were the three important factors that had the greatest impacts on the bacterial community distribution in the long-term petroleum-contaminated soils.Our research has provided references for the bacterial community distribution along a petroleum gradient in both surface and subsurface petroleum-contaminated soils of oilfield areas. 展开更多
关键词 Petroleum-contaminated soil Dagang Oilfield Bacterial community diversity 16s rRNA Illumina sequencing Environmental factor correlation analysis
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老年高血压中医护理干预分析 预览
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作者 李雅丽 《数理医药学杂志》 2020年第1期147-148,共2页
目的:对老年高血压患者实施中医护理干预进行观察探讨。方法:选取某院2017年7月~2017年11月期间收治的老年高血压患者250例,按照不同的护理方法分为观察组和对照组,每组125例。观察组实施中医护理干预,对照组实施常规护理干预,对比两组... 目的:对老年高血压患者实施中医护理干预进行观察探讨。方法:选取某院2017年7月~2017年11月期间收治的老年高血压患者250例,按照不同的护理方法分为观察组和对照组,每组125例。观察组实施中医护理干预,对照组实施常规护理干预,对比两组患者的临床护理满意度。结果:经过中医护理干预后的观察组患者满意度明显高于对照组(92.0%/77.6%),两组数据差异明显且有统计学意义,P<0.05。结论:经过中医护理干预后老年高血压患者的临床症状改善和降压效果得到了积极的作用。 展开更多
关键词 老年高血压 中医护理干预 分析
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醚化蒸馏塔底重沸器结焦原因分析及对策探讨 预览
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作者 田勇震 杨忠义 +2 位作者 宋颖 杨刚 毕才平 《石油石化绿色低碳》 2020年第1期26-31,共6页
大连石化公司100万吨/年轻汽油醚化装置开工运行至今,醚化蒸馏塔底重沸器由于管束外壁结焦导致换热效率下降,先后两次更换重沸器管束,严重影响装置生产运行。通过对原料性质、结焦物化验数据、同类装置原料性质和操作条件对比以及结焦... 大连石化公司100万吨/年轻汽油醚化装置开工运行至今,醚化蒸馏塔底重沸器由于管束外壁结焦导致换热效率下降,先后两次更换重沸器管束,严重影响装置生产运行。通过对原料性质、结焦物化验数据、同类装置原料性质和操作条件对比以及结焦机理等进行分析,确定了重沸器结焦的原因是二烯烃在酸性环境和一定温度下发生聚合。催化蒸馏段脱落的催化剂树脂中磺酸根为二烯烃的聚合提供了酸性环境,重沸器管程热流介质为二烯烃聚合提供了高温环境。根据结焦原因有针对性地提出了解决对策和优化建议,优化调整后,周期内重沸器管程换热温差平均下降速率目前为1.8℃/月,同比降低0.7℃/月,预期重沸器管束运行周期可提高至两年半以上,在合适工况下可满足三年一修的大检修周期。 展开更多
关键词 醚化装置 重沸器结焦 分析 对策
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信阳地区特种稻种子氨基酸含量的检测分析 预览
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作者 彭波 黄新华 +9 位作者 何璐璐 刘子月 彭娟 孙艳芳 庞瑞华 宋晓华 李金涛 汪全秀 郑梦阳 宋世枝 《信阳师范学院学报:自然科学版》 CAS 北大核心 2020年第1期46-53,共8页
以信阳地区具有代表性的20份特种稻为试验材料,采用近红外谷物分析仪,对其种子中的氨基酸含量进行检测与分析.结果表明:不同特种稻种子中的总体氨基酸含量存在明显差异,黑香稻与信粳糯631种子中总氨基酸含量相差26.64 mg/g;总的必需氨... 以信阳地区具有代表性的20份特种稻为试验材料,采用近红外谷物分析仪,对其种子中的氨基酸含量进行检测与分析.结果表明:不同特种稻种子中的总体氨基酸含量存在明显差异,黑香稻与信粳糯631种子中总氨基酸含量相差26.64 mg/g;总的必需氨基酸以及各类必需氨基酸含量存在丰富的变异,特别是豫农32和矮秆香稻丸等特种稻品种内总的必需氨基酸含量较高;在20份特种稻种子中限制性氨基酸含量、杂环族氨基酸含量以及芳香族氨基酸含量均存在较大的变异,其中来源于息县的矮杆香稻丸种子中赖氨酸含量、杂环族氨基酸含量和芳香族氨基酸含量均相对较高.因此,针对信阳地区特种稻种子中总氨基酸含量、限制性氨基酸含量以及必需氨基酸含量均较高的品种,可以考虑作为优质特种稻新品种选育的骨干亲本. 展开更多
关键词 特种稻 种子 氨基酸含量 检测 分析
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A Broad Learning-Driven Network Traffic Analysis System Based on Fog Computing Paradigm 预览
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作者 Xiting Peng Kaoru Ota Mianxiong Dong 《中国通信:英文版》 SCIE CSCD 2020年第2期1-13,共13页
The development of communication technologies which support traffic-intensive applications presents new challenges in designing a real-time traffic analysis architecture and an accurate method that suitable for a wide... The development of communication technologies which support traffic-intensive applications presents new challenges in designing a real-time traffic analysis architecture and an accurate method that suitable for a wide variety of traffic types.Current traffic analysis methods are executed on the cloud,which needs to upload the traffic data.Fog computing is a more promising way to save bandwidth resources by offloading these tasks to the fog nodes.However,traffic analysis models based on traditional machine learning need to retrain all traffic data when updating the trained model,which are not suitable for fog computing due to the poor computing power.In this study,we design a novel fog computing based traffic analysis system using broad learning.For one thing,fog computing can provide a distributed architecture for saving the bandwidth resources.For another,we use the broad learning to incrementally train the traffic data,which is more suitable for fog computing because it can support incremental updates of models without retraining all data.We implement our system on the Raspberry Pi,and experimental results show that we have a 98%probability to accurately identify these traffic data.Moreover,our method has a faster training speed compared with Convolutional Neural Network(CNN). 展开更多
关键词 traffic analysis fog computing broad learning radio access networks
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我国近年药品审评审批政策文件分析 预览
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作者 陈一飞 金德庄 《世界中医药》 CAS 2020年第2期286-295,共10页
自2015年8月国务院《关于改革药品医疗器械审评审批制度的意见》(国发[2015]44号,44号文)出台以来,我国药品医疗器械审评审批制度改革持续推进。为了更好地理解我国药品审评审批制度改革,本文对我国2015年8月18日至2018年12月31日期间... 自2015年8月国务院《关于改革药品医疗器械审评审批制度的意见》(国发[2015]44号,44号文)出台以来,我国药品医疗器械审评审批制度改革持续推进。为了更好地理解我国药品审评审批制度改革,本文对我国2015年8月18日至2018年12月31日期间的相关法规政策文件进行检索、梳理、综述,以期对药品行业政策发展趋势进行浅析,对行业提供参考。 展开更多
关键词 药品 审评审批 政策文件 分析
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