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Effect of paclitaxel and resveratrol on New Zealand rabbit semen
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作者 Caner Oztürk Mehmet Bozkurt Ataman 《亚太生殖杂志(英文版)》 2018年第6期266-269,共4页
Objective:To examine the effects of paclitaxel and resveratrol on rabbit semen.Methods:This study consisted of four groups: control group (40 mL saline), paclitaxel group (5 mg/kg paclitaxel), resveratrol group (4 mg/... Objective:To examine the effects of paclitaxel and resveratrol on rabbit semen.Methods:This study consisted of four groups: control group (40 mL saline), paclitaxel group (5 mg/kg paclitaxel), resveratrol group (4 mg/kg resveratrol) and paclitaxel+resveratrol group (5 mg/kg paclitaxel+4 mg/kg resveratrol). Administrations werei.v.(in 40 mL saline) and continued 8 weeks. Sperm motility was evaluated using phase-contrast microscopy. Mitochondrial activity, membrane and acrosome integrity were performed by fluorescence staining. Lipid peroxidation, total glutathione and antioxidant potential levels were determined by spectrophotometry.Results: Paclitaxel decreased the sperm motility and fluorescence staining results compared to the control (P<0.05). The paclitaxel and resveratrol group showed better results of the same parameters compared to the paclitaxel group (P<0.05). No significant difference was observed in lipid peroxidation, total glutathione, antioxidant potential and fertility results (P>0.05). Results of this study showed that paclitaxel decreased semen parameters and resveratrol had a protective effect on these parameters.Conclusions:Paclitaxel has negative effects on spermatological indicators and biochemical assays, while resveratrol prevents these negative effects of paclitaxel. 展开更多
关键词 ANTIOXIDANT ANTICANCER drug SPERM parameters Oxidative stress
Curcumin can influence synaptic dysfunction in APPswe/PS1dE9 mice 预览
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作者 Fang Chen Yingkun He +5 位作者 Pengwen Wang Peng Wei Huili Feng Yingxue Rao Jing Shi Jinzhou Tian 《中医科学杂志(英文)》 2018年第2期168-176,共9页
Objective:Synaptic loss in the hippocampus in Alzheimer's disease (AD) has been shown to be closely associated with the cognitive impairment.Synaptic dysfunction is a pathological feature that occurs prior to syna... Objective:Synaptic loss in the hippocampus in Alzheimer's disease (AD) has been shown to be closely associated with the cognitive impairment.Synaptic dysfunction is a pathological feature that occurs prior to synaptic loss and mainly depends on structural changes and alterations of synaptic proteins.Evidence has suggested that curcumin,obtained from the traditional Chinese medicine—Turmeric (Curcuma longa L.),can ameliorate cognitive impairment,but few studies have focused on the mechanism by which curcumin affects synapses at early stages of AD.Therefore,we performed a study to investigate whether curcumin exerted its effect on synapses at the early stage in AD.Methods:We used 3-month-old APPswe/PS1dE9 mice and wild type (WT) littermates of the APPswe/PS1dE9 mice from the same colony as the normal controls.Seventy-five APPswe/ PS1dE9 mice were allocated to the Model group,Rosiglitazone group,and Curcumin groups randomly.The Wild and Model groups were orally administered an equal amount of 0.5% carboxymethyl cellulose (CMC).We observed the ultrastructure of synapses in the CA1 area of hippocampus and analyzed the expression levels of PSD95 and Shank1,two important synapseassociated proteins,in APPswe/PS1dE9 mice by immunohistochemical staining and western blot after gavage for three months.Results:Our findings showed that curcumin treatment not only improved the quantity and ultrastructure of synapses but also increased the expression of PSD95 and Shank1.Conclusion:The results indicate that curcumin improves synaptic dysfunction and the potential mechanism may involve improving the structure of synapses and regulating the synapse related proteins PSD95 and Shank1. 展开更多
关键词 ALZHEIMER SYNAPSE ULTRASTRUCTURE SYNAPTIC PROTEINS
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Oxcarbazepine oral suspension in pediatric patients with partial seizures and/or generalized tonic-clonic seizures: a multi-center, single arm, observational study in China
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作者 Yi Wang Yin-Bo Chen +7 位作者 Yu-Qin Zhang Rong Luo Hua Wang Jun-Lan Lv Dong Wang Sui-Qiang Zhu Zhong-Dong Lin Jiong Qin 《世界儿科杂志(英文版)》 2017年第6期551-559,共9页
Background:To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical p... Background:To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China.Methods:This 26-week,single arm,multicenter and observational study recruited patients aged 2-16 years with PS or GTCS suitable for OXC oral suspension treatment.Enrolled patients received OXC oral suspension treatment for 26 weeks.Primary endpoints included mean seizure frequency at the end of the treatment and mean seizure frequency reduction at the end of the treatment vs.baseline.Secondary efficacy-related endpoints and safety parameters were also assessed.Results:Nine hundred and eighty-seven pediatric patients were enrolled and 912 (92.4%) completed the study.The mean seizure frequencies at baseline and the end of week 26 were 13.40±64.92 and 1.62±19.47 times/month,respectively.The mean seizure frequency reduction was 10.03±63.67 times/month and the mean seizure frequency reduction percentage was 90.02%±5127.0% (P<0.0001).After 26 weeks of treatment,82.36%,7.24% and 3.86% of the patients became controlled,significantly improved and improved,respectively.Adverse events (AEs) were reported in 74 (7.65%) patients.Rash was the most common AE.The efficacy of OXC was not affected by seizure types,age or gender.Conclusion:This study confirms the efficacy and good safety profile of OXC oral suspension in Chinese pediatric patients aged 2-16 years with PS and/or GTCS. 展开更多
关键词 children efficacy generalized tonic-clonic seizures OXCARBAZEPINE ORAL SUSPENSION partial seizures
Predictors of severity and outcome and roles of intravenous thrombolysis and biomarkers in first ischemic stroke
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作者 Kartick Chandra Ghosh Ramesh Bhattacharya +4 位作者 Saikat Ghosh Manoj Mahata Sarbajit Das Suman Das Gourango Prosad Mondal 《神经免疫与神经炎症(英文版)》 2018年第9期24-34,共11页
Aim: Stroke is one of the leading causes of death and disability. The proportion of patients receiving recombinant tissue plasminogen activator is low in our country. Biomarkers to identify patients at risk of severe ... Aim: Stroke is one of the leading causes of death and disability. The proportion of patients receiving recombinant tissue plasminogen activator is low in our country. Biomarkers to identify patients at risk of severe disease, and guide treatment and prognosis would be valuable. This article aims to identify the factors that can independently prognosticate the acute phase of ischemic stroke. Methods: All patients with the first episode of ischemic stroke admitted to the Neurology Department between 1st December 2017 to 31st March 2018 were included in this pilot study. Stroke severity was evaluated using the National Institute of Health Stroke Scale (NIHSS). Patients being admitted within 4.5 h of onset of symptoms were thrombolysed with injection alteplase. For each patient, 4 serum biomarkers (D-dimer, fibrinogen, C-reactive pro-tein and neuron specific enolase) were evaluated at admission and 24 h later. Discharged patients were assessed on an outpatient basis using the modified Rankin scale. The study primarily aimed to identify the factors predicting the severity and outcome of stroke, and to evaluate the effect of thrombolysis on the outcome. The secondary aim was to evaluate the role of biomarkers to predict the unfavorable outcome and the chance of post thrombolysis hemor-rhage. Results: Out of 30 patients included in the study, 10 had NIHSS 0-4, 12 had NIHSS 5-15 and 8 had NIHSS 16-42. Sixteen patients had unfavorable outcome (mRS score ≥ 2), and 5 patients expired. Old age, history of diabetes, CHADS2 score ≥ 2, and total anterior circulation stroke (TACS) independently affected stroke severity, whereas lowejection fraction < 35%, and TACS, independently predicted unfavorable outcome and mortality. High mean arte-rial blood pressure (MABP) and capillary blood glucose (CBG) at admission were significant predictors of stroke severity, unfavorable outcome, and mortality. Out of 10 thrombolysed patients, two had mRS score ≥ 2 and 3 had the post-thrombolysis hemorrhage. Thrombolysis significantly reduce 展开更多
关键词 First-ever ischemic STROKE THROMBOLYSIS biomarkers total anterior circulation STROKE FIBRINOGEN
Meningeal carcinomatosis: a retrospective analysis of seventy-seven cases
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作者 Feng-Na Chu Yue Lang +1 位作者 Xiao-Min Sun Li Cui 《神经免疫与神经炎症(英文版)》 2017年第1期1-5,共5页
Aim:Meningeal carcinomatosis is a special type of malignant tumor characterized by short survival and poor prognosis.In the present study,the authors aim to analyze the clinical,laboratory data and prognosis of mening... Aim:Meningeal carcinomatosis is a special type of malignant tumor characterized by short survival and poor prognosis.In the present study,the authors aim to analyze the clinical,laboratory data and prognosis of meningeal carcinomatosis patients.Methods:The authors enrolled 77 cases of meningeal carcinomatosis from 2003 to 2013 in the First Hospital of Jilin University.The clinical data including age,gender,symptoms at onset,clinical manifestations,primary tumors and the laboratory data including cerebrospinal fluid (CSF),tumor markers as well as the imaging data were analyzed.The interval between the onset of primary tumor and the onset of central nervous symptoms,treatments and survival time were also analyzed.Results:The onset of meningeal carcinomatosis was usually acute (46.2%) or subacute (39.0%).The most frequent symptom at onset was intracranial hypertension (70.1%).Symptoms such as headache,vomit and high lumbar puncture intracranial pressure was observed in 56% of cases during the course of the disease.CSF abnormalities such as higher protein concentration (73.4%),more CSF pleocitosis (57.1%) and lower glucose levels (48.4%) were found in 95.3% of meningeal carcinomatosis patients.Non-contrast enhanced cerebral magnetic resonance imaging (MRI) showed that 13.2% patients had abnormal meningeal changes while in the enhancement scan 35.3% patients showed changes.The serum tumor markers increased in 84% of the patients.There were no differences regarding the mean survival between patients who received intrathecal chemotherapy and those who received brain radiotherapy or supportive treatment.Conclusion:The most common clinical manifestation of meningeal carcinomatosis is intracranial hypertension.The most common primary tumor is lung cancer,followed by gastric cancer and breast cancer.The linear enhancement of meningeal on the MRI scan is of great importance for the diagnosis of meningeal carcinomatosis. 展开更多
关键词 MENINGEAL CARCINOMATOSIS CEREBROSPINAL fluid magnetic RESONANCE imaging therapy
Correlation of serum ROBO4 and sB7-H4 contents with the pathological features of tumor in patients with ovarian cancer
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作者 Wen-Liang Yu 《海南医科大学学报(英文版)》 2019年第11期75-78,共4页
Objective:To study the correlation of serum ROBO4 and soluble B7-H4 (sB7-H4) contents with the pathological features of tumor in patients with ovarian cancer.Methods:The patients with ovarian cancer and the patients w... Objective:To study the correlation of serum ROBO4 and soluble B7-H4 (sB7-H4) contents with the pathological features of tumor in patients with ovarian cancer.Methods:The patients with ovarian cancer and the patients with ovarian benign tumor who underwent surgical resection in our hospital between March 2015 and August 2017 were selected, and the contents of ROBO4 and sB7-H4 in serum as well as the expression of ROBO4, B7-H4 and oncogenes in the lesion tissues were determined.Results: ROBO4 content in serum of patients with ovarian cancer was significantly lower than that of patients with ovarian benign tumor whereas sB7-H4 content was significantly higher than that of patients with ovarian benign tumor, ROBO4 mRNA expression in ovarian cancer tissues was significantly lower than that in ovarian benign tumor tissues whereas B7-H4 mRNA expression was significantly higher than that in ovarian benign tumor tissues, and ROBO4 and sB7-H4 contents in serum of patients with ovarian cancer were positively correlated with ROBO4 and B7-H4 mRNA expression in ovarian cancer tissues;the higher the FIGO stage and pathological grade of the tumor is, the lower the ROBO4 content and the higher the sB7-H4 content in serum of patients with ovarian cancer will be;β-catenin, CyclinD1 and MMP9 mRNA expression in ovarian cancer tissues were significantly higher than those in ovarian benign tumor tissues, negatively correlated with ROBO4 and positively correlated with sB7-H4 whereas PTEN and E-cadherin mRNA expression were significantly lower than those in ovarian benign tumor tissues, positively correlated with ROBO4 and negatively correlated with sB7-H4.Conclusion: The changes of ROBO4 and sB7-H4 contents in serum of patients with ovarian cancer are closely related to the changes of clinicopathologic stage and the abnormal expression of oncogenes. 展开更多
关键词 OVARIAN cancer ROBO4 SOLUBLE B7-H4 ONCOGENE
Effect of ulinastatin on the pathological links related to myocardial injury and ischemia reperfusion after cardiac surgery under cardiopulmonary bypass
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作者 Ke-Qi Xie Qing Xia +1 位作者 Ji-Wen Luo Wei Yang 《海南医科大学学报(英文版)》 2018年第17期39-42,共4页
Objective: To study the effect of ulinastatin on the pathological links related to myocardial injury and ischemia reperfusion after cardiac surgery under cardiopulmonary bypass. Methods: The patients undergoing valve ... Objective: To study the effect of ulinastatin on the pathological links related to myocardial injury and ischemia reperfusion after cardiac surgery under cardiopulmonary bypass. Methods: The patients undergoing valve replacement under cardiopulmonary bypass between February 2015 and December 2017 in Mianyang Central Hospital of Sichuan Province were chosen as the research subjects and randomly divided into the experimental group who accepted ulinastatin + creatine phosphate sodium intervention and the control group who accepted creatine phosphate sodium intervention. The levels of myocardial injury markers, apoptosis molecules, inflammation molecules and oxidative stress molecules in serum as well as the expression intensity of inflammation molecules and oxidative stress molecules in peripheral blood were determined before surgery and 24 h after surgery. Results: Serum cTnI, CK-MB, H-FABP, sFasL, sTWEAK, Caspase-3, Caspase-8, IL-1β, TNF-α, ICAM1, MDA and NO levels as well as peripheral blood TLR4, NLRP3, NOX2 and iNOS expression intensity of both groups of patients after surgery were significantly higher than those before surgery, and serum cTnI, CK-MB, H-FABP, sFasL, sTWEAK, Caspase-3, Caspase-8, IL-1β, TNF- , ICAM1, MDA and NO levels as well as peripheral blood TLR4, NLRP3, NOX2 and iNOS expression intensity of experimental group after surgery were significantly lower than those of control group. Conclusion: Ulinastatin can improve the apoptosis, inflammation and oxidative stress related to myocardial injury and ischemia reperfusion after cardiac surgery under cardiopulmonary bypass. 展开更多
关键词 CARDIOPULMONARY BYPASS ULINASTATIN Iischemia REPERFUSION injury Apoptosis Inflammation Oxidative stress
Ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents
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作者 Hui-Ming Hu Xiao-Wei Song Xin-Yu Zhou 《海南医科大学学报(英文版)》 2018年第4期124-127,共4页
Objective: To investigate the ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents. Methods: A total of 76 patients with gestational... Objective: To investigate the ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents. Methods: A total of 76 patients with gestational hypertension who were treated in Guangyuan Central Hospital between August 2015 and February 2017 were selected as gestational hypertension group, and 50 healthy pregnant women who received regular prenatal examination in Guangyuan Central Hospital during the same period were selected as normal control group. The differences in the ultrasonic left cardiac function parameter levels as well as serum contents of endothelial injury indexes and inflammatory factors were compared between the two groups of pregnant women. Pearson test was used to assess the correlation of ultrasonic left cardiac function parameter levels of gestational hypertension with serum endothelial injury index and inflammatory factor contents. Results: LAVmax, LVESV and LVEDV levels in gestational hypertension group were significantly higher than those in normal control group;serum endothelial injury indexes NO and PGE2 contents were lower than those of normal control group whereas ET-1 content was higher than that of normal control group;serum inflammatory factors IL-2, IFN-γ, IL-10, IL-13, IL-17 and IL-23 contents were significantly higher than those of normal control group. Correlation analysis showed that the ultrasonic left cardiac function parameter levels in patients with gestational hypertension were directly correlated with serum content of endothelial injury indexes and inflammatory factors. Conclusion: Ultrasonic left cardiac function parameter levels significantly change in patients with gestational hypertension, and the specific levels are directly correlated with the degree of endothelial injury and inflammatory response in the pregnant women. 展开更多
关键词 GESTATIONAL hypertension Ultrasonic LEFT CARDIAC FUNCTION ENDOTHELIAL FUNCTION Inflammatory factor
Correlation of serum YKL-40 content with eosinophil function as well as Th1/Th2 and Treg/Th17 immunity in patients with allergic rhinitis
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作者 Kuyaxi·Pilidong Jun Yong 《海南医科大学学报(英文版)》 2017年第20期142-145,共4页
Objective: To discuss the correlation of serum YKL-40 content with eosinophil function as well as Th1/Th2 and Treg/Th17 immunity in patients with allergic rhinitis. Methods: A total of 310 patients with allergic rhini... Objective: To discuss the correlation of serum YKL-40 content with eosinophil function as well as Th1/Th2 and Treg/Th17 immunity in patients with allergic rhinitis. Methods: A total of 310 patients with allergic rhinitis who were treated in the hospital between January 2015 and May 2017 were selected as allergic rhinitis group and 100 healthy volunteers who received physical examination in the hospital during the same period were selected as normal control group. The differences in serum YKL-40 content, eosinophil function as well as Th1/Th2 and Treg/Th17 cytokine contents were compared between the two groups. Pearson test was used to assess the correlation between serum YKL-40 content and disease severity in patients with allergic rhinitis. Results: Serum YKL-40 content of allergic rhinitis group was higher than that of normal control group;serum eosinophil function IgE and Eotaxin-2 contents of allergic rhinitis group were higher than those of normal control group;serum Th1 cytokines IFN-γand IL-12 contents were lower than those of normal control group while Th2 cytokines IL-4 and IL-13 contents were higher than those of normal control group;serum Treg cytokine TGF-β content was lower than that of normal control group while Th17 cytokine IL-17 content was higher than that of normal control group. Pearson test showed that serum YKL-40 content in patients with allergic rhinitis was directly correlated with the eosinophil function as well as Th1/Th2 and Treg/Th17 immunity. Conclusion: Serum YKL-40 content is abnormally high in patients with allergic rhinitis, and the specific expression is positively correlated with the disease severity. 展开更多
关键词 Allergic rhinitis YKL-40 EOSINOPHIL TH1/TH2 IMMUNITY Treg/Th17 IMMUNITY
The correlation of PCT, SAA and CD64 levels in peripheral blood with the inflammatory response and viscera function in neonate with sepsis
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作者 Song Li Ling Luo 《海南医科大学学报(英文版)》 2017年第4期125-128,共4页
Objective:To study the correlation of PCT, SAA and CD64 levels in peripheral blood with the inflammatory response and viscera function in neonate with sepsis.Methods: A total of 35 neonates diagnosed with sepsis in ou... Objective:To study the correlation of PCT, SAA and CD64 levels in peripheral blood with the inflammatory response and viscera function in neonate with sepsis.Methods: A total of 35 neonates diagnosed with sepsis in our hospital between March 2014 and March 2016 were selected as the sepsis group of the study, 60 healthy neonates born in our hospital during the same period were selected as the control group, peripheral blood samples were collected to determine the levels of PCT, SAA, CD64 as well as inflammatory factors, myocardial injury marker molecules and liver injury marker molecules.Results:PCT, SAA, CD64, sTREM-1, TNF-α, IL-6, IL-8, cTnI, cTnT, H-FABP, CK-MB, AST, ALT, GGT, TBIL and DBIL levels in peripheral blood of sepsis group were significantly higher than those of control group;PCT, SAA and CD64 levels in peripheral blood were positively correlated with sTREM-1, TNF-α, IL-6, IL-8, cTnI, cTnT, H-FABP, CK-MB, AST, ALT, GGT, TBIL and DBIL levels. Conclusion: PCT, SAA and CD64 levels in peripheral blood of neonatal sepsis significantly increase and are associated with the degree of inflammation, myocardial injury and liver injury. 展开更多
关键词 SEPSIS Neonatal PROCALCITONIN Serum amyloid A Inflammation
肾癌根治术39例分析 预览
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作者 朱劲松 鲍彤 《蚌埠医学院学报》 CAS 2007年第6期 726-727,共2页
目的:探讨肾癌手术治疗的方法与效果.方法:单纯肾癌根治性切除22例,肾癌根治性切除加淋巴结清扫17例.结果:35例随访2~8年, 5年存活率Ⅰ期77%,Ⅱ期65%,Ⅲ期25%,Ⅳ期20%.结论:肾癌根治术仍是肾癌主要治疗方法,淋巴结清扫不能提高患者生存率.
关键词 肾肿瘤 肾癌根治术 淋巴结清扫术
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恶性胶质瘤同步放射化学治疗继以动脉灌注嘧啶亚硝脲治疗观察 被引量:19
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作者 左焕琮 王世杰 +2 位作者 赵奎明 唐文渊 马廉亭 《中华神经外科杂志》 CSCD 北大核心 1996年第4期,共4页
1987年11月至1991年2月对55例手术后恶性胶质瘤(星形细胞瘤Ⅲ级或Ⅳ级)患者分成三组继续治疗:A组(14例)行同步放射化学治疗,随后每隔3~6个月行患侧动脉灌注嘧啶亚硝脲(ACNU)治疗;B组(16例)单纯行... 1987年11月至1991年2月对55例手术后恶性胶质瘤(星形细胞瘤Ⅲ级或Ⅳ级)患者分成三组继续治疗:A组(14例)行同步放射化学治疗,随后每隔3~6个月行患侧动脉灌注嘧啶亚硝脲(ACNU)治疗;B组(16例)单纯行同步放射化学治疗;C组(25例)单纯放射治疗以作对照。近期效果用CT扫描比较,同步放射化学治疗的有效率(63%)高于单纯放射治疗(28%)P值<0.01。55例患者均行连续随访,1、2、3年生存率A组(93%,62%,50%)明显高于C组(51%,13%,13%),P值<0.001。B组1,2年生存率高于C组,但无统计学差别。作者认为采用同步放射化学治疗继以动脉灌注ACNU维持治疗对恶性胶质瘤术后患者是一个较佳的选择治疗方案。 展开更多
关键词 恶性胶质瘤 同步放射化学治疗 动脉ACNU灌注 放射治疗
变性梯度凝胶电泳和单链构象多态性分析检测肺癌p53基因8号外显子突变 预览
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作者 倪培华 郭雪君 +3 位作者 邓伟吾 巫向前 黄薇 时国朝 《上海医学》 CAS CSCD 北大核心 1998年第5期,共2页
目的:检测p53基因8号外显子突变。方法:分别采用变性梯度凝胶电泳(DGGE)和单链构象多态性分析(SSCP),对35例肺癌病人手术切除组织的p53基因8号外显子(Exon8)进行突变检测。结果:采用DGGE检测的突... 目的:检测p53基因8号外显子突变。方法:分别采用变性梯度凝胶电泳(DGGE)和单链构象多态性分析(SSCP),对35例肺癌病人手术切除组织的p53基因8号外显子(Exon8)进行突变检测。结果:采用DGGE检测的突变率为20%,而SSCP检测的突变率为11%。p53基因Exon8的总突变率为23%。结论:DGGE检测p53基因突变的敏感性高于SSCP。 展开更多
关键词 P53基因 变性梯度凝胶电泳 单链构象多态性分析
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二胺氧化酶在肝癌组织中的基因表达 预览 被引量:2
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作者 王红珊 王红梅 +1 位作者 吴琳 简美贞 《临床医药实践》 2007年第9期 805-807,共3页
目的:探讨二胺氧化酶(DAO)在人类原发性肝癌组织中基因表达.方法:应用半定量逆转录-聚合酶链反应(RT-PCR)方法检测22 例人类正常肝脏组织、36 例人原发性肝癌旁组织和36 例人原发性肝癌组织新鲜标本中基因mRNA的表达情况.结果:在肝癌组... 目的:探讨二胺氧化酶(DAO)在人类原发性肝癌组织中基因表达.方法:应用半定量逆转录-聚合酶链反应(RT-PCR)方法检测22 例人类正常肝脏组织、36 例人原发性肝癌旁组织和36 例人原发性肝癌组织新鲜标本中基因mRNA的表达情况.结果:在肝癌组织中DAO基因呈高表达.结论:肝脏中DAO基因表达随肿瘤的发展而变化. 展开更多
关键词 原发性肝癌组织 二胺氧化酶 RT-PCR
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WIF-1研究进展 预览 被引量:1
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作者 任杰 周清华 《中国肺癌杂志》 CAS 2007年第3期 248-252,共5页
  肿瘤发生、发展是一个极其复杂的多基因调控和多步骤发展过程.它涉及到机体、肿瘤细胞和靶组织的相互影响和作用,还涉及到一系列肿瘤相关基因的结构和功能的异常.   Wnt抑制因子-1(Wnt inhibitory factor-1,WIF-1)是近年来发现...   肿瘤发生、发展是一个极其复杂的多基因调控和多步骤发展过程.它涉及到机体、肿瘤细胞和靶组织的相互影响和作用,还涉及到一系列肿瘤相关基因的结构和功能的异常.   Wnt抑制因子-1(Wnt inhibitory factor-1,WIF-1)是近年来发现的肿瘤抑制因子,它通过结合Wnt蛋白抑制Wnt通路的活性,并因此被命名.…… 展开更多
关键词 肿瘤相关基因 非小细胞肺癌 信号通路 大肠癌细胞株 WIF-1 肿瘤抑制因子 细胞外基质 基因沉默 信号传导通路 消化系统肿瘤
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经肛门拖出双吻合器保肛术治疗超低位直肠癌 预览
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作者 张双元 杨守仁 +2 位作者 李生根 才旦多杰 燕速 《青海医药杂志》 2007年第12期 13-14,共2页
目的:总结经肛门拖出双吻合器保肛术治疗超低位直肠癌的经验.方法:2004年4月-2007年10月对29例超低位直肠癌进行了经肛门拖出双吻合器保留肛门括约肌手术.结果:29例低位直肠癌病人均保留了有控制大便功能的肛门,术后发生吻合口瘘2例.复... 目的:总结经肛门拖出双吻合器保肛术治疗超低位直肠癌的经验.方法:2004年4月-2007年10月对29例超低位直肠癌进行了经肛门拖出双吻合器保留肛门括约肌手术.结果:29例低位直肠癌病人均保留了有控制大便功能的肛门,术后发生吻合口瘘2例.复发2例,无手术死亡,结论:经肛门拖出双吻合器保肛术治疗低位直肠癌简化了手术操作,安全可行. 展开更多
关键词 直肠肿瘤 外科缝合器
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鼻唇沟的基底细胞癌:表面“良性”的肿瘤常需复杂手术 预览
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作者 Garcia L Nagore E Llombart B. 李政霄 《世界核心医学期刊文摘:皮肤病学分册》 2006年第12期共1页
背景:肿瘤的部位是基底细胞癌(BCC)复发的一个很好的预后因子。我们观察到定位于鼻唇沟的肿瘤可能需要特别留意。目的:本研究旨在与低度危险区的对照组BCC患者相比,评估位于鼻唇沟的BCC的状态,以测定其暗含的更复杂治疗或考虑辅助治疗... 背景:肿瘤的部位是基底细胞癌(BCC)复发的一个很好的预后因子。我们观察到定位于鼻唇沟的肿瘤可能需要特别留意。目的:本研究旨在与低度危险区的对照组BCC患者相比,评估位于鼻唇沟的BCC的状态,以测定其暗含的更复杂治疗或考虑辅助治疗的特征。方法:回顾性分析从1997年1月至2000年12月本文从M ohs外科学数据库中24例鼻唇沟BCC患者。对照组是从该数据库中挑选的颊部或额部的37例BCC患者。评估两组患者在临床、手术和组织病理特征等方面的差异。结果:鼻唇沟BCC患者表现为尺寸较小和未常规治疗前的首发症状,到进展的时间比对照组短,多数病理显示为无侵袭性的组织亚型,但需要较多的手术过程和较复杂的外科重建。结论:本文观察了鼻唇沟BCC患者,尽管表现出较好的临床和组织病理特征,却需要更复杂的外科手术。研究认为该区域需要特别注意,未来还应进行更多的前瞻性研究来证实这一观点。鼻唇沟的基底细胞癌:表面“良性”的肿瘤常需复杂手术@Garcia L @Nagore E$Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain... 展开更多
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浅谈残胃癌28例临床诊治 预览
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作者 高俊峰 《现代保健:医学创新研究》 2006年第8期 184-,共1页
  胃十二指肠溃疡行胃大部切除术5年后残胃发生的原发性癌称为残胃癌[1].本病男性多于女性,文献报道的比例为5:4~13:1,年龄多在55~60岁[2,5].残胃癌发生与原基础疾病有很大关系,胃溃疡术后较十二指肠溃疡术后残胃癌发生率高达3~4倍...   胃十二指肠溃疡行胃大部切除术5年后残胃发生的原发性癌称为残胃癌[1].本病男性多于女性,文献报道的比例为5:4~13:1,年龄多在55~60岁[2,5].残胃癌发生与原基础疾病有很大关系,胃溃疡术后较十二指肠溃疡术后残胃癌发生率高达3~4倍[2,4].胃切除术的术式与残胃癌的发生有密切关系,各类报道均趋一致.…… 展开更多
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伊立替康联合顺铂治疗复发卵巢癌40例的临床疗效 预览 被引量:10
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作者 苑树俐 马荣 陈曦海 《中国新药与临床杂志》 CAS CSCD 北大核心 2005年第2期 122-125,共4页
目的:观察伊立替康联合顺铂治疗复发卵巢癌的效果.方法:将82例复发卵巢癌病人分成2组,试验组(40例)和对照组(42例),试验组每个疗程给予伊立替康200 mg,在化学治疗(化疗)的d 1,8静脉滴注(静滴);顺铂100 mg,d 1~5静滴;对照组氟尿嘧啶1 50... 目的:观察伊立替康联合顺铂治疗复发卵巢癌的效果.方法:将82例复发卵巢癌病人分成2组,试验组(40例)和对照组(42例),试验组每个疗程给予伊立替康200 mg,在化学治疗(化疗)的d 1,8静脉滴注(静滴);顺铂100 mg,d 1~5静滴;对照组氟尿嘧啶1 500 mg和顺铂100 mg,按常规剂量给予.观察2组卵巢癌上皮抗原(CA125)值、病灶缩小情况、生存率、不同病理类型对其敏感度以及不良反应的差异.结果:试验组CA125下降率22 %,病灶缩小率28 %,1年生存率70 %,对照组分别为10 %,7 %,33 %,差异有显著意义(P<0.05).透明细胞癌较浆液性癌对伊立替康更敏感.试验组的不良反应主要是腹泻、呕吐、中性粒细胞减少和肠梗阻.结论:伊立替康联合顺铂可成为一种有效的、优于对照组的治疗复发卵巢癌的药物. 展开更多
关键词 卵巢肿瘤 抗肿瘤联合化疗方案 药物疗法 联合 伊立替康
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膀胱癌肉瘤1例报告 预览
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作者 杜永年 王江 杜宇阳 《中外医疗》 2008年第16期,共1页
针对根治性膀胱癌切除患者进行跟踪观察与随访,现将结果报道如下。
关键词 膀胱肿瘤 癌肉瘤
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