期刊文献+
共找到95篇文章
< 1 2 5 >
每页显示 20 50 100
Fe含量对Ti5553合金α相析出响应与硬化行为的影响 预览
1
作者 朱文光 李沛 +6 位作者 孙逊 陈威 张华磊 孙巧艳 刘彬 肖林 孙军 《中国有色金属学报:英文版》 SCIE EI CAS CSCD 2019年第6期1242-1251,共10页
利用混合元素烧结法制备含0、0.4、1.2和2.0wt.%Fe的Ti5553合金。研究Fe元素对绝热ω相变、α相析出长大以及时效硬化行为的影响规律。结果表明,2wt.%Fe元素的加入可提高β相的稳定性,抑制绝热ω相析出。随着Fe含量增加,α相析出孕育期... 利用混合元素烧结法制备含0、0.4、1.2和2.0wt.%Fe的Ti5553合金。研究Fe元素对绝热ω相变、α相析出长大以及时效硬化行为的影响规律。结果表明,2wt.%Fe元素的加入可提高β相的稳定性,抑制绝热ω相析出。随着Fe含量增加,α相析出孕育期变长,尺寸变小。α相沿晶析出倾向增强,尤其是在炉冷时,Ti5553-2Fe合金形成明显的魏氏组织。随后,利用Pandat软件并结合经典动力学理论分析Fe含量对Ti5553合金α相析出长大行为的影响机制。硬度曲线表明,不同Fe含量合金的硬度均随时效时间延长先增加,6h达到峰值后缓慢降低。Ti5553-2Fe合金具有最高的峰值硬度,这是Fe等合金元素点阵错配引起的固溶强化与细小α相析出引起的时效强化共同作用的结果。 展开更多
关键词 Fe改性Ti5553合金 α相析出长大 硬化行为 Pandat计算
在线阅读 下载PDF
Effects of deuteration on the structure of NH4H2PO4 crystals characterized by neutron diffraction
2
作者 刘宝安 朱丽丽 +6 位作者 刘发付 孙洵 陈喜平 谢雷 夏元华 孙光爱 巨新 《中国物理B:英文版》 SCIE EI CAS CSCD 2019年第1期484-489,共6页
A series of deuterated ammonium dihydrogen phosphate(DADP) crystals were grown and their structures were investigated by using powder neutron diffraction method. In the entire composition range, the deuterated level i... A series of deuterated ammonium dihydrogen phosphate(DADP) crystals were grown and their structures were investigated by using powder neutron diffraction method. In the entire composition range, the deuterated level in the crystals is lower compared with the aqueous growth solution. The deuterium segregation coefficient in the crystals decreases with increasing deuterium content of the solution. The deuterium content in the NH4+ group is higher than that in H2PO4- group.In addition, the variations of lattice parameters are shown here. 展开更多
关键词 DADP CRYSTAL NEUTRON DIFFRACTION DEUTERATION LEVEL
食管皮脂腺异位内镜表现和临床病理分析(附国内19例报告) 预览
3
作者 徐佰国 孟祥伟 +1 位作者 孙逊 刘磊 《中国内镜杂志》 2019年第9期89-92,共4页
目的总结食管皮脂腺异位的内镜表现和病理特点,提高临床、内镜和病理医生对该病的认识和诊断能力。方法收集吉林大学白求恩第一医院收治的5例以上消化道症状起病的食管皮脂腺异位患者的临床资料,并检索文献中的14例食管皮脂腺异位的患... 目的总结食管皮脂腺异位的内镜表现和病理特点,提高临床、内镜和病理医生对该病的认识和诊断能力。方法收集吉林大学白求恩第一医院收治的5例以上消化道症状起病的食管皮脂腺异位患者的临床资料,并检索文献中的14例食管皮脂腺异位的患者资料,分析该病患者的内镜下表现和病理特点。结果19例患者中2例无临床症状,其余以上腹部不适、上腹部饱胀、上腹痛、胸骨后哽咽感、进食异物感、反酸和烧心等就诊,其中胸骨后哽咽感、进食异物感与该病相关性强,该病无阳性体征。该病内镜下常见诊断为黄色(斑)瘤(26.32%)、脂肪瘤(15.79%)、食管结节性增生(5.26%)、霉菌性食管炎(5.26%)和食管白斑(5.26%)等,误诊率高,病变多位于食管中下段(84.21%)。所有患者均经病理证实为食管皮脂腺异位,病理表现为成熟或幼稚皮脂腺细胞。结论食管皮脂腺异位为少见临床病变,临床无特异症状,误诊率高,应提高鉴别诊断能力,特别是与浅表型食管癌鉴别。该病确诊有赖于内镜及病理活检,预后较好。 展开更多
关键词 食管皮脂腺 皮脂腺异位 内镜下表现 鉴别诊断 病理特点 误诊
在线阅读 下载PDF
Sodium selenite ameliorates dextran sulfate sodiuminduced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses 预览
4
作者 Li-Xuan Sang Bing Chang +6 位作者 Jun-Feng Zhu Fang-Li Yang Yan Li Xue-Feng Jiang Da-Nan Wang Chang-Long Lu Xun Sun 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第21期3850-3863,共14页
AIM To assess the effect of sodium selenite on the severity of dextran sulfate sodium(DSS)-induced colitis in C57BL/6 mice.METHODS Mice were randomly divided into four groups(n = 10/group): normal group, selenium(Se) ... AIM To assess the effect of sodium selenite on the severity of dextran sulfate sodium(DSS)-induced colitis in C57BL/6 mice.METHODS Mice were randomly divided into four groups(n = 10/group): normal group, selenium(Se) group, chronic colitis group, and Se + chronic colitis group. The mice were sacrificed on day 26. Survival rates, clinical symptoms, colon length, and histological changes were determined. The percentages and absolute numbers of immune system cells in the lamina propria lymphocytes(LPL) of the colon, the expression of m RNA in colon tissue, and the concentrations of Th1, Th17, and Treg cytokines in LPL from the large intestine, were measured.RESULTS Se significantly ameliorated the symptoms of colitis and histological injury(P < 0.05 each), increasing the proportions of neutrophils and CD4+ CD25+ T cells(P < 0.05 each) and decreasing the proportions of γδT cells, CD4+, CD4+CD44+, and CD4+ CD69+ T cells in LPL(P < 0.05 each). Moreover, Se reduced the expression of IL-6, IFN-γ, IL-17 A, IL-21, T-bet, and RORγt(P < 0.05 each), but enhanced the expression of IL-10 and Foxp3(P < 0.05 each). CONCLUSION These results suggest that Se protects against DSSinduced chronic colitis perhaps by increasing the number of CD4(+)CD25(+) Tregs that suppress the secretion of proinflammatory cytokines and populations of Th1, Th17, and γδT cells. 展开更多
在线阅读 免费下载
Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms
5
作者 Hui-fang SU Qing LIN +4 位作者 Xin-yi WANG Yao FU Tao GONG Xun SUN Zhi-rong ZHANG 《中国药理学报:英文版》 SCIE CAS CSCD 2016年第4期545-554,共10页
瞄准:分别地,(+)-Catechin 和 puerarin 在绿茶和食品是多酚和 flavonoid。他们展出有势力抗氧化剂活动并且广泛地被使用治疗 cardiocerebrovascular 疾病。这个工作的目的是调查在在 Caco-2 房间 monolayers.Methods 在老鼠,和他们... 瞄准:分别地,(+)-Catechin 和 puerarin 在绿茶和食品是多酚和 flavonoid。他们展出有势力抗氧化剂活动并且广泛地被使用治疗 cardiocerebrovascular 疾病。这个工作的目的是调查在在 Caco-2 房间 monolayers.Methods 在老鼠,和他们的吸收机制跟随并发的口头的管理的(+)-catechin 和 puerarin 之间的潜在的相互作用:Pharmacokinetic 研究在雄的老鼠被进行收到的(+)-catechin (140 mg/kg, po ) 或 puerarin (200 mg/kg, po ) 。在 Caco-2 房间单层和二混合物的相互作用的房间举起和运输行为是 analyzed.Results:当(+)-catechin 和 puerarin 并发地被管理时, AUC <sub>0-12 h </sub> 和 C <sub > 分别地, puerarin 的最大 </sub> 价值是 2.48 褶层和 3.91 褶层 puerarin 象那些一样大独自一个;AUC <sub>0-12 h </sub> 和 C <sub > 分别地,(+)-catechin 的最大 </sub> 价值独自(+)-catechin 与那些相比被减少到 57.62% 和 77.55% 。在 Caco-2 房间单层,(+)-catechin (300 和 600 &#x003BC; mol/L ) 显著地增加了房间举起和 puerarin 的运输,而 puerarin (300 和 600 &#x003BC; mol/L ) 显著地减少了(+)-catechin 的细胞的举起和运输。而且, cyclosporine A (P-glycoprotein 禁止者) 和 MK-571 (MRP-2 禁止者) 显著地增加了(+)-catechin 和 puerarin.Conclusion 的细胞的举起和运输:(+)-catechin 和 puerarin 的并发的口头的管理显著地增加了 puerarin 的绝对口头的 bioavailability,但是减少(+)-catechin 的。由 P-glycoprotein 和 MRP-2 的(+)-catechin 和 puerarin 的竞争流出可能在小肠在他们的吸收过程期间导致这个相互作用。 展开更多
关键词 相互作用 吸收机制 雄性大鼠 葛根素 儿茶素 口服 CACO-2细胞 P-糖蛋白
喜树碱-环糊精-纳米金自组装制剂的制备及抗肿瘤活性初探 预览 被引量:2
6
作者 胥运 居新 +2 位作者 潘敏 孙逊 张晟 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2016年第8期149-154,共6页
首先在金纳米粒子表面修饰了α-环糊精(α-CD),并利用α-CD与难溶性药物喜树碱的主客体包合,成功得到了一种新型的金粒子喜树碱增溶制剂(CPT-αCD/AuNPs)。研究表明,CPT-αCD/AuNPs的增溶效果可达29.04μg/m L,优于绝大多数载体;载... 首先在金纳米粒子表面修饰了α-环糊精(α-CD),并利用α-CD与难溶性药物喜树碱的主客体包合,成功得到了一种新型的金粒子喜树碱增溶制剂(CPT-αCD/AuNPs)。研究表明,CPT-αCD/AuNPs的增溶效果可达29.04μg/m L,优于绝大多数载体;载体本身生物相容性良好。并且,金粒子-药物的多价效应和增溶效应的双重作用使这种新型体系表现出远优于自由喜树碱(CPT)和单纯环糊精包合CPT的癌细胞杀灭效果。 展开更多
关键词 自组装 喜树碱 抗肿瘤 增溶 Α-环糊精
在线阅读 下载PDF
Human umbilical cord mesenchymal stem cells promote peripheral nerve repairvia paracrine mechanisms 预览
7
作者 Zhi-yuan Guo Xun Sun +3 位作者 Xiao-long Xu Qing Zhao Jiang Peng Yu Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2015年第4期651-658,共8页
Human umbilical cord-derived mesenchymal stem cells(h UCMSCs) represent a promising young-state stem cell source for cell-based therapy. h UCMSC transplantation into the transected sciatic nerve promotes axonal regene... Human umbilical cord-derived mesenchymal stem cells(h UCMSCs) represent a promising young-state stem cell source for cell-based therapy. h UCMSC transplantation into the transected sciatic nerve promotes axonal regeneration and functional recovery. To further clarify the paracrine effects of h UCMSCs on nerve regeneration, we performed human cytokine antibody array analysis, which revealed that h UCMSCs express 14 important neurotrophic factors. Enzyme-linked immunosorbent assay and immunohistochemistry showed that brain-derived neurotrophic factor, glial-derived neurotrophic factor, hepatocyte growth factor, neurotrophin-3, basic fibroblast growth factor, type I collagen, fibronectin and laminin were highly expressed. Treatment with h UCMSC-conditioned medium enhanced Schwann cell viability and proliferation, increased nerve growth factor and brain-derived neurotrophic factor expression in Schwann cells, and enhanced neurite growth from dorsal root ganglion explants. These findings suggest that paracrine action may be a key mechanism underlying the effects of h UCMSCs in peripheral nerve repair. 展开更多
关键词 间充质干细胞 分泌机制 外周神经 脑源性神经营养因子 碱性成纤维细胞生长因子 脐带 肝细胞生长因子 酶联免疫吸附试验
在线阅读 下载PDF
基于主客体识别的自组装金粒子基因载体的构建与性能评价 预览
8
作者 李罗浩 孙逊 张晟 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2015年第7期143-148,153共7页
利用金纳米粒子及环糊精-二茂铁主客体识别作用,制备了2种不同形状的H2O2响应性基因载体GP2(球形)、GR2(棒状),并与传统转染试剂Lipo2000及PEI25k进行了转染及毒性的系统比较。结果表明,2种形状的粒子在同等条件下的转染效率超过了L... 利用金纳米粒子及环糊精-二茂铁主客体识别作用,制备了2种不同形状的H2O2响应性基因载体GP2(球形)、GR2(棒状),并与传统转染试剂Lipo2000及PEI25k进行了转染及毒性的系统比较。结果表明,2种形状的粒子在同等条件下的转染效率超过了Lipo2000及PEI25k,且棒状粒子的转染效率更高。同时,在可用于转染的范围内,2种粒子表现出与PEI10k相当的较低细胞毒性。 展开更多
关键词 金纳米粒子 H2O2响应 形状效应 基因传递
在线阅读 下载PDF
Effect of raw material and growth method on optical properties of DKDP crystal
9
作者 刘宝安 胡国行 +2 位作者 张清华 孙洵 许心光 《中国光学快报:英文版》 SCIE EI CAS CSCD 2014年第10期91-95,共5页
Three kinds of KH2PO4 raw material are used to grow deuterated potassium dihydrogen phosphate(DKDP) crystals by traditional and rapid growth methods,respectively. The growth habit dependence on the purity of raw mater... Three kinds of KH2PO4 raw material are used to grow deuterated potassium dihydrogen phosphate(DKDP) crystals by traditional and rapid growth methods,respectively. The growth habit dependence on the purity of raw material is described and analyzed. The optical properties including transmission spectra and laser-induced damage threshold of these crystals are measured. It is found that the growth method affects the optical properties of crystal more obviously than the raw material with the mass content of main metal ions below 1 ppm. Moreover,the morphology of the core in the observed damage sites indicates that an explosion process probably occurs during laser-induced breakdown. 展开更多
关键词 DKDP晶体 原材料 光学性能 KH2PO4 激光诱导 磷酸二氢钾 生长习性 光学特性
Synthesis and in vivo distribution of 2-deoxy-2-aminodiglucose-prednisolone conjugate(DPC)
10
作者 Yan Lin Xun Sun Tao Gong Zhi Rong Zhang 《中国化学快报:英文版》 SCIE CAS CSCD 2012年第5期 557-560,共4页
<正>In order to develop a novel kidney-targeted drug delivery system,a small molecular carrier(2-deoxy-2-aminodiglucose) was synthesized,and then the 2-deoxy-2-aminodiglucose-prednisolone conjugate(DPC) was synt... <正>In order to develop a novel kidney-targeted drug delivery system,a small molecular carrier(2-deoxy-2-aminodiglucose) was synthesized,and then the 2-deoxy-2-aminodiglucose-prednisolone conjugate(DPC) was synthesized to verify the kidney targeting capability of the carrier.Both 2-deoxy-2-aminodiglucose and DPC were confirmed by NMR and MS spectrum.The tissue distribution studies showed that DPC presented an excellent kidney targeting property in vivo,compared with prednisolone group, 4.9-fold of drug concentration in kidney was observed in the DPC group.Thus,it indicated that 2-deoxy-2-aminodiglucose could be a potential carrier for kidney-targeted drug delivery. 展开更多
关键词 DPC 强的松 脱氧 合成 体内 共轭 靶向给药系统 靶向载体
Mixed micelles loaded with sil.ybin-polyene phosphatidylcholine complex improve drug solubility 被引量:3
11
作者 Rui-ling DUAN Xun SUN Jie LIU Tao GONG Zhi-rong ZHANG 《中国药理学报:英文版》 SCIE CAS CSCD 2011年第1期108-115,共8页
关键词 水溶解度 混合胶束 复合加载 卵磷脂 药物 ZETA电位 差示扫描量热法 扫描电子显微镜
Effect of Ba in KDP crystal on the wavelength dependence of laser-induced damage
12
作者 高慧 孙洵 +3 位作者 许心光 刘宝安 徐明霞 赵显 《中国光学快报:英文版》 SCIE EI CAS CSCD 2011年第9期40-41,共2页
Ba impurity in potassium dihydrogen phosphate(KDP) is studied with the first-principle simulation method. The relaxed configurations and density of the states of KDP crystal with Ba impurity are calculated. We find th... Ba impurity in potassium dihydrogen phosphate(KDP) is studied with the first-principle simulation method. The relaxed configurations and density of the states of KDP crystal with Ba impurity are calculated. We find that Ba can generate a K vacancy and an interstitial O-H unit for charge compensation. The band gap of KDP crystal narrowed down to about 3.9 eV,which is consistent with the experimental data from previously reported studies and indicates that Ba may be a source of low-damage threshold. 展开更多
关键词 KDP晶体 激光损伤 BA 波长 磷酸二氢钾 模拟方法 第一原理 密度计算
A Novel Technique for the Preparation of ~(125)I-5-trimethylstannyl-1-(2-deoxy-2-fluoro-beta-D-arabino-furanosyl) Urail and Its Biodistribution Pattern in Kunming Mice 预览
13
作者 胡佳 张永学 +5 位作者 孙逊 李多兰 李崇佼 覃春霞 曹卫 兰晓莉 《华中科技大学学报:医学英德文版》 SCIE CAS 2011年第5期 693-695,共3页
In this study, a novel technique for the preparation of 125I-5-trimethylstannyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) urail (FIAU) was developed, 125I-FIAU biodistribution profile was detected in Kunming mice a... In this study, a novel technique for the preparation of 125I-5-trimethylstannyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) urail (FIAU) was developed, 125I-FIAU biodistribution profile was detected in Kunming mice and the possibility of using FTAU radio-labeling for reporter gene imaging was explored. 5-trimethylstannyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) urail (FTAU) was labeled with radioiodine (125I). A rotary evaporation method was used to remove excess methanol. The reactant was purified through a Sep-Pak C18 reversal phase column. The radiochemical purity and in vivo stability were determined using silica gel thin layer chromatography (TLC). The biodistribution of 125I-FIAU in Kunming mice was also detected. The results showed that 125I-FIAU could be radiolabeled effectively with FTAU, with mean labeling rate being (81±0.38)% (n =5). The mean radiochemical purity of (98.01±0.40)% (n=5) was achieved after a reversal phase Sep-park column purification. 125I-FIAU was stable when incubated in normal human serum or in saline at 37°C, with a radiochemical purity >96% during a 0.5-24 h time period. Biological experiments exhibited rapid clearance of 125I-FIAU from the blood pool. 125I-FIAU was mostly excreted by kidneys. 125I-FIAU in myocardium dropped conspicuously after 8 h and there was hardly retention at 24 h. We were led to concluded that the new method of radioiodinization of FTAU for the preparation of 125I-FIAU is easy, highly effective and stable in vivo. The biodistribution of 125I-FIAU in Kunming mice showed it can serve as an imaging probe for myocardial reporter genes. 展开更多
关键词 昆明小鼠 体内 脱氧 分布格局 技术 放射化学纯度 制备
在线阅读 下载PDF
Non-interactive identity-based threshold signature scheme without random oracles 预览
14
作者 Xun SUN Jian-hua LI +1 位作者 Shu-tang YANG Gong-liang CHEN 《浙江大学学报:A卷英文版》 SCIE EI CAS CSCD 2008年第6期 727-736,共10页
一(t, n ) 阀值签名计划以那个任何东西 t+1 或更诚实的播放器设置了的一个方法散布 n 播放器的秘密关键和因此签名能力能协作签名,当时 t 播放器的任何集合不能。在这篇论文,我们从双线性的白族戒指建议一个基于身份的阀值签名(IBTH... 一(t, n ) 阀值签名计划以那个任何东西 t+1 或更诚实的播放器设置了的一个方法散布 n 播放器的秘密关键和因此签名能力能协作签名,当时 t 播放器的任何集合不能。在这篇论文,我们从双线性的白族戒指建议一个基于身份的阀值签名(IBTHS ) 计划。我们的计划的签名阶段是不相关的,意味着签名播放器不需要与对方谈话。我们证明我们的计划安全(即, unforgeable 并且柔韧) 在标准模型(即,没有随机的神谕) 。没有更早建议的 IBTHS 计划完成了弄平是不相关的特征之一(在签名阶段) 并且在标准模型安全。 展开更多
关键词 计算机技术 交互式 数据库 数字签名
在线阅读 下载PDF
升清胶囊对胆囊胆固醇结石小鼠模型生化学指标的影响 预览 被引量:8
15
作者 章学林 梁晓强 +4 位作者 顾宏刚 马恩伟 林天碧 孙逊 张静喆 《中西医结合学报》 CAS 2008年第10期 1045-1048,共4页
目的:观察疏肝利胆中药升清胶囊对胆囊胆固醇结石小鼠生化学指标的影响。方法:38只C57BL/6J雌性小鼠随机分为正常对照组(n=10)、模型组(n=15)和升清胶囊组(n=13)。除正常对照组外,模型组和升清胶囊组小鼠采用高脂饮食诱发法建... 目的:观察疏肝利胆中药升清胶囊对胆囊胆固醇结石小鼠生化学指标的影响。方法:38只C57BL/6J雌性小鼠随机分为正常对照组(n=10)、模型组(n=15)和升清胶囊组(n=13)。除正常对照组外,模型组和升清胶囊组小鼠采用高脂饮食诱发法建立胆固醇结石模型。造模过程中,升清胶囊组小鼠予升清胶囊0.22 g/(kg.d)灌胃治疗。8周后观察各组小鼠的成石率、血脂含量、血清钙离子浓度、肝脏丙二醛(malondialdehyde,MDA)含量及超氧化物歧化酶(superoxide dismutase,SOD)活性。结果:模型组成石率为73.33%,明显高于正常对照组和升清胶囊组,差异有统计学意义(P〈0.01)。升清胶囊组血清总胆固醇和低密度脂蛋白含量低于模型组(P〈0.01),高密度脂蛋白含量高于模型组(P〈0.01);升清胶囊组小鼠肝脏SOD活性升高和MDA含量下降,与模型组比较,差异有统计学意义(P〈0.05)。结论:升清胶囊可通过降低小鼠胆固醇结石模型成石率,改善血清和肝脏的生化学相关指标,从而发挥防治胆石病的作用。 展开更多
关键词 升清胶囊 胆固醇结石 小鼠 胆固醇 丙二醛 超氧化物歧化酶
在线阅读 下载PDF
安徽省高校篮球运动现状与发展对策 预览 被引量:11
16
作者 荀笋 《黄山学院学报》 2006年第3期 127-130,共4页
通过对安徽省普通高校的大学生篮球运动兴趣、师资队伍、教学状况、场地设施、竞赛、课外训练、高水平篮球队与学生篮球运动社团的现状与存在的问题进行调查与分析,并提出相应的发展对策与措施。
关键词 安徽省高校 篮球运动 现状 对策
在线阅读 下载PDF
对“奎潭湖畔体育花”凋谢的思考——兼论农村群众体育发展对策 预览
17
作者 荀笋 《体育文化导刊》 北大核心 2006年第5期 17-19,共3页
通过查阅文献资料与访问调查,文章对“文革”时期一个全国“群众体育先进基层单位”兴衰过程进行分析,面对农村现状与将来发展趋势,提出加大宣传、明确发展战略等发展对策.
关键词 农村 群众体育 发展对策
在线阅读 下载PDF
Expression of interferon-alpha/beta receptor protein in liver of patients with hepatitis C virus-related chronic liver disease 预览
18
作者 Xiang-WeiMeng Bao-RongChi Li-GangChen Ling-LingZhang YanZhuang Hai-YanHuang XunSun 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2005年第25期3962-3965,共4页
AIM: To study the expression of interferon-alpha/beta (IFN-α/β) receptor protein in liver of patients with hepatitis C virus (HCV)-related chronic liver disease and its clinical significance.METHODS: A total of 181 ... AIM: To study the expression of interferon-alpha/beta (IFN-α/β) receptor protein in liver of patients with hepatitis C virus (HCV)-related chronic liver disease and its clinical significance.METHODS: A total of 181 patients with HCV-related chronic liver disease included 56 with HCV-related liver cirrhosis (LC) and 125 with chronic hepatitis C (CHC).CHC patients were treated with five megaunits of interferon-α1b six times weekly for the first 2 weeks and then every other day for 22 wk. The patients were divided into interferon (IFN) treatment-responsive and nonresponsive groups, but 36 patients lost follow-up shortly after receiving the treatment. The expression of IFN-α/β receptor (IFN-α/βR) protein in liver of all patients was determined with immunofluorescence.RESULTS: In liver of patients with HCV-related chronic liver disease, the expression of IFN-α/βR protein in liver cell membrane was stronger than that in cytoplasm and more obvious in the surroundings of portal vein than in the surroundings of central vein. Moreover, it was poorly distributed in hepatic Iobules. The weak positive, positive and strong positive expression of IFN-α/βR were 40% (50/125), 28% (35/125), 32% (40/125), respectively in CHC group, and 91.1% (51/56), 5.35% (3/56), and 3.56% (2/56), respectively in LC group. The positive and strong positive rates were higher in CHC group than in LC group (P<0.01). In IFN treatment responsive group, 27.8% (10/36) showed weak positive expression; 72.2% (26/36)showed positive or strong positive expression. In the nonresponsive group, 71.7% (38/53) showed weak positive expression; 28.3% (15/53) showed positive or strong positive expression. The expression of IFN-α/βR protein in liver was more obvious in IFN treatment responsive group than in non-responsive group.CONCLUSION: Expression of IFN-α/βR protein in liver of patients with HCV-related chronic liver disease is likely involved in the response to IFN treatment. 展开更多
关键词 干扰素-Α 干扰素-Β 丙型肝炎 慢性肝疾病
在线阅读 免费下载
β-BaB_2O_4 with special cut-angle applied to single crystal cascaded third-harmonic generation
19
作者 任宏凯 亓宏伟 +5 位作者 王正平 吴志心 王梦霞 孙玉祥 孙洵 许心光 《中国物理B:英文版》 SCIE EI CAS CSCD 2018年第11期477-480,共4页
不同种类化肥与生物菌肥配合施用对生姜生物性状和产量的影响初报 预览
20
作者 陆晴 李娟 +5 位作者 张爱敏 王永存 刘新红 宋志莲 张宏玉 孙逊 《农业科学》 2018年第4期254-258,共5页
为了提高唐山地区生姜的生物性状和产量,促进肥料在田间安全高效的应用,笔者于2017年进行不同种类化肥混施生物菌肥试验。结果表明,海法钾宝混施菌肥后生姜的植株生理指标比单施肥料均有增加,撒可富混施菌肥后生姜叶片对强光的耐受性增... 为了提高唐山地区生姜的生物性状和产量,促进肥料在田间安全高效的应用,笔者于2017年进行不同种类化肥混施生物菌肥试验。结果表明,海法钾宝混施菌肥后生姜的植株生理指标比单施肥料均有增加,撒可富混施菌肥后生姜叶片对强光的耐受性增强,Fv/Fm比值达到0.57;除硫酸钾以外,其他混施生物菌肥的生姜产量均比之前有所提高,其中撒可富混施菌肥后产量比混施前增加14.00%,而硫酸钾混施菌肥后比混施前下降15.13%;撒可富与菌肥混施后产量最高,比对照增产38.97%,呈差异显著,其次为海法钾宝混施菌肥,比对照增产37.27%。因此,选取撒可富或海法钾宝混施生物菌肥,均有利于提高生姜的整体生长势、增加生姜产量,硫酸钾则不适宜与生物菌肥混用。 展开更多
关键词 生姜 生物菌肥 生物性状 产量
在线阅读 下载PDF
上一页 1 2 5 下一页 到第
使用帮助 返回顶部 意见反馈