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Role of penehyclidine in acute organophosphorus pesticide poisoning 预览
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作者 Shi-yuan Yu Yan-xia Gao +8 位作者 Joseph Walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li 《世界急诊医学杂志(英文)》 CAS CSCD 2020年第1期37-47,共11页
BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane l... BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone. 展开更多
关键词 PENEHYCLIDINE Organophosphorus pesticide poisoning META-ANALYSIS
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Novel ATL1 mutation in a Chinese family with hereditary spastic paraplegia: A case report and review of literature 预览
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作者 Xue-Wen Xiao Juan Du +8 位作者 Bin Jiao Xin-Xin Liao Lu Zhou Xi-Xi Liu Zhen-Hua Yuan Li-Na Guo Xin Wang Lu Shen Zhang-Yuan Lin 《世界临床病例杂志》 2019年第11期1358-1366,共9页
BACKGROUND Hereditary spastic paraplegias (HSPs) refer to a group of heterogeneous neurodegenerative diseases characterized by lower limbs spasticity and weakness. So far, over 72 genes have been found to cause HSP (S... BACKGROUND Hereditary spastic paraplegias (HSPs) refer to a group of heterogeneous neurodegenerative diseases characterized by lower limbs spasticity and weakness. So far, over 72 genes have been found to cause HSP (SPG1-SPG72). Among autosomal dominant HSP patients, spastic paraplegia 4 (SPG4/SPAST) gene is the most common pathogenic gene, and atlastin-1 (ATL1) is the second most common one. Here we reported a novel ATL1 mutation in a Chinese spastic paraplegia 3A (SPG3A) family, which expands the clinical and genetic spectrum of ATL1 mutations. CASE SUMMARY A 9-year-old boy with progressive spastic paraplegia accompanied by right hearing loss and mental retardation for five years was admitted to our hospital.Past history was unremarkable. The family history was positive, and his grandfather and mother had similar symptoms. Neurological examinations revealed hypermyotonia in his lower limbs, hyperreflexia in knee reflex, bilateral positive Babinski signs and scissors gait. The results of blood routine test, liver function test, blood glucose test, ceruloplasmin test and vitamin test were all normal. The serum lactic acid level was significantly increased. The testing for brainstem auditory evoked potential demonstrated that the right side hearing was impaired while the left was normal. Magnetic resonance imaging showed mild atrophy of the spinal cord. The gene panel test revealed that the proband carried an ATL1 c.752A>G p.Gln251Arg (p.Q251R) mutation, and Sanger sequencing confirmed the existence of family co-segregation. CONCLUSION We reported a novel ATL1 Q251R mutation and a novel clinical phenotype of hearing loss in a Chinese SPG3A family. 展开更多
关键词 HEREDITARY SPASTIC PARAPLEGIA SPG3A Atlastin-1 (ATL1) gene HEARING loss Case report
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“兰台e令”网站数据库设计与功能实现 预览
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作者 喻盛甲 许新华 +4 位作者 向启凤 郭博露 刘新 袁浩 辛香婷 《信息技术与信息化》 2019年第6期105-108,共4页
为了实现对电子档案、用户以及日志的管理,选用MySQL数据库设计了文件表和档案表等多个数据表;使用Shiro框架技术,完成了管理员登录,经过SpringMVC框架技术,完成了档案文件的上传与下载,通过ShareSDK技术,实现了分享功能;本网站经过反... 为了实现对电子档案、用户以及日志的管理,选用MySQL数据库设计了文件表和档案表等多个数据表;使用Shiro框架技术,完成了管理员登录,经过SpringMVC框架技术,完成了档案文件的上传与下载,通过ShareSDK技术,实现了分享功能;本网站经过反复测试与试用,在网站功能方面,基本上满足了我国家庭档案“Anytime,Anywhere,Anyone”的网络化管理需求。 展开更多
关键词 档案管理 兰台e令 数据库 功能
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Performance of risk stratification systems for gastrointestinal stromal tumors: A multicenter study 预览
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作者 Tao Chen Liang-Ying Ye +11 位作者 Xing-Yu Feng Hai-Bo Qiu Peng Zhang Yi-Xin Luo Li-Yi Yuan Xin-Hua Chen Yan-Feng Hu Hao Liu Yong Li Kai-Xiong Tao Jiang Yu Guo-Xin Li 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第10期1238-1247,共10页
BACKGROUND Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumor type in the gastrointestinal system. Presently, various classification systems to prognosticate GISTs have been proposed.AIM To e... BACKGROUND Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumor type in the gastrointestinal system. Presently, various classification systems to prognosticate GISTs have been proposed.AIM To evaluate the application value of four different risk stratification systems for GISTs.METHODS Patients who were diagnosed with GISTs and underwent surgical resection at four hospitals from 1998 to 2015 were identified from a database. Risk of recurrence was stratified by the modified National Institute of Health(NIH)criteria, the Armed Forces Institute of Pathology(AFIP) criteria, the Memorial Sloan Kettering Cancer Center(MSKCC) prognostic nomogram, and the contour maps. Receiver operating characteristic(ROC) curves were established to compare the four abovementioned risk stratification systems based on the area under the curve(AUC).RESULTS A total of 1303 patients were included in the study. The mean age of the patients was 55.77 ± 13.70 yr;52.3% of the patients were male. The mean follow-up period was 64.91 ± 35.79 mo. Approximately 67.0% the tumors were located in the stomach, and 59.5% were smaller than 5 cm;67.3% of the patients had a mitotic count ≤ 5/50 high-power fields(HPFs). Thirty-four tumors ruptured before and during surgery. Univariate analysis demonstrated that tumor size > 5 cm(P <0.05), mitotic count > 5/50 HPFs(P < 0.05), non-gastric location(P < 0.05), and tumor rupture(P < 0.05) were significantly associated with increased recurrence rates. According to the ROC curve, the AFIP criteria showed the largest AUC(0.754).CONCLUSION According to our data, the AFIP criteria were associated with a larger AUC than the NIH modified criteria, the MSKCC nomogram, and the contour maps, which might indicate that the AFIP criteria have better accuracy to support therapeutic decision-making for patients with GISTs. 展开更多
关键词 GASTROINTESTINAL stromal TUMORS Risk STRATIFICATION Prognosis Modified National Institute of Health CRITERIA Armed Forces Institute of Pathology CRITERIA MEMORIAL Sloan Kettering Cancer Center prognostic NOMOGRAM Contour maps GASTROINTESTINAL TUMORS
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Genetic Structure of <i>Spinibarbus caldwelli</i>Based on mtDNA D-Loop 预览
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作者 Xiping Yuan Xin Yang +1 位作者 Hongzi Ge Hong Li 《农业科学(英文)》 2019年第2期173-180,共8页
Spinibarbus caldwelli was an endemic species to China, and its germplasm protection and resources utilization had become more and more concerned. To know its genetic diversity and differentiation, the mitochondrial DN... Spinibarbus caldwelli was an endemic species to China, and its germplasm protection and resources utilization had become more and more concerned. To know its genetic diversity and differentiation, the mitochondrial DNA D-loop was amplified and sequenced for 148 individuals from four regions of Pearl River and Yangtze River Basin. Altogether 9 variable nucleotide sites existed among the aligned sequences of 748 bp, and 8 haplotypes were found within 148 individuals. The average nucleotide diversity (Pi) was high 0.00297, while haplotype diversity (Hd) was 0.706. The average genetic distance was 0.00298, most value occurred between LJ and CL populations, and small value occurred between HJ and QZ populations. 展开更多
关键词 Spinibarbus caldwelli Genetic Structure MTDNA D-LOOP
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Temporal Distribution of Fish Community Structure in Dongting Lake Estuary 预览
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作者 Xiping Yuan Xin Yang +2 位作者 Hongzi Ge Hong Li Daqing Deng 《农业科学(英文)》 2019年第3期294-301,共8页
The Dongting Lake Estuary is migration pathways for some river-lake migratory and semi-migratory fishes. In the present study, an annual survey of fish was conducted from January to November 2018 covering a total of 6... The Dongting Lake Estuary is migration pathways for some river-lake migratory and semi-migratory fishes. In the present study, an annual survey of fish was conducted from January to November 2018 covering a total of 6 sites in Dongting Lake Estuary. A total of 57 freshwater species and subspecies belonging to 5 orders and 10 families were recorded. The catches at the Dongting Lake Estuary were mainly composed of Lake settled fish. The biomass of Cyprinus (Cyprinus) carpio Linnaeus was the highest, accounting for 25.53% of the total catches, followed by Hypophthalmichthys molitrixs, Culter alburnus Basilewsky and Ctenopharyngodon idellus, accounting for 10.41%, 8.99% and 7.10% of the total catches, respectively. The four major domestic carps accounted for 26.13% of the total catch. The range of richness of species varied between 40 and 51 species. The trend was fewer species in spring, with the arrival of summer and autumn gradually increasing, peaking at the turn of summer and autumn, and then gradually decreasing with the arrival of winter, to the lowest in spring. The Shannon, Simpson, Pielou and Margalef indices showed the consistent trends with richness of species. 展开更多
关键词 BIODIVERSITY Dongting LAKE ESTUARY FRESHWATER FISH
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翻转课堂在《动力气象学》教学应用中的可行性分析 预览
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作者 李扬 周欣 +4 位作者 原渊 华维 宋敏红 李明刚 袁亮 《教育教学论坛》 2019年第42期177-178,共2页
《动力气象学》是大气科学专业本科阶段的重要核心课程。本研究通过问卷调查法对翻转课堂教学模式应用于该课程的可行性进行了分析。结果表明,尽管现如今流行的翻转课堂教学模式本着激发学生兴趣,让学生实现自主学习的目的,但对于当今... 《动力气象学》是大气科学专业本科阶段的重要核心课程。本研究通过问卷调查法对翻转课堂教学模式应用于该课程的可行性进行了分析。结果表明,尽管现如今流行的翻转课堂教学模式本着激发学生兴趣,让学生实现自主学习的目的,但对于当今大气科学类高校可能不太适应。主要有以下四个原因:其一,翻转课堂的教学效果严重依赖学生的自主性和互动性;其二,不能保证所有教师对于翻转课堂教学模式都能接受;其三,现有信息技术支持不足;其四,现有教学资源的开发力度不够。 展开更多
关键词 翻转课堂 动力气象学 可行性分析
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A mine drainage treatment system for AMD in remediation of metal sulfide mines 预览
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作者 Shi-Tian Hou Jing-Yi Cai +4 位作者 Ke-Yan Tan Hong Yang Xin Hu Zhe Wang Xin Yuan 《中国地质(英文)》 2019年第3期396-397,共2页
1. Objective In the process of mining, sorting and smelting metal sulfide mines, a large amount of acid mine drainage (AMD) containing concentrated sulfate (SO4 ^2-) and various metal elements (Fe, Mn, Cu, Zn, Ni, etc... 1. Objective In the process of mining, sorting and smelting metal sulfide mines, a large amount of acid mine drainage (AMD) containing concentrated sulfate (SO4 ^2-) and various metal elements (Fe, Mn, Cu, Zn, Ni, etc.) are produced. In order to solve current problems of mine acid drainage, we have improved the existing repair technology based on biogeochemical technology, and provided a new treatment system for AMD from metal sulfide mines. 展开更多
关键词 SMELTING BIOGEOCHEMICAL a LARGE AMOUNT of
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人居地学环境初论 预览
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作者 辛建荣 李同德 袁昕 《决策与信息》 2019年第2期40-47,共8页
人居地学是研究人类聚居空间所在区域的地质学和地理学环境特征的边缘学科。人居地学环境是人居环境与自然系统的结合,主要研究人类聚居地的地学环境和生存条件及其变化特征;分析人居地学环境的基本要素及其空间差异性和时间演变性;以... 人居地学是研究人类聚居空间所在区域的地质学和地理学环境特征的边缘学科。人居地学环境是人居环境与自然系统的结合,主要研究人类聚居地的地学环境和生存条件及其变化特征;分析人居地学环境的基本要素及其空间差异性和时间演变性;以人地融合思想和地学工程学理论为城市规划、工程建设等提供科学指导和服务;提升建设宜居城市和人居环境工程的科学性;解决城市所面临的生态环境困境。人居地学环境研究的意义在于科学建立人居用地的理论体系,寻求不同地域文明的自然成因基础. 展开更多
关键词 人居地学 人地关系 人居地学环境 地学环境要素 宜居城市建设
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Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress 预览
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作者 Yun-Kai Xie Xin Zhou +5 位作者 Hong-Tao Yuan Jie Qiu Dan-Qing Xin Xi-Li Chu Da-Chuan Wang Zhen Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1734-1742,共9页
Previous studies have shown that resveratrol,a bioactive substance found in many plants,can reduce early brain injury after subarachnoid hemorrhage,but how it acts is still unclear.This study explored the mechanism us... Previous studies have shown that resveratrol,a bioactive substance found in many plants,can reduce early brain injury after subarachnoid hemorrhage,but how it acts is still unclear.This study explored the mechanism using the experimental subarachnoid hemorrhage rat model established by injecting autologous blood into the cerebellomedullary cistern.Rat models were treated with an intraperitoneal injection of 60 mg/kg resveratrol 2,6,24 and 46 hours after injury.At 48 hours after injury,their neurological function was assessed using a modified Garcia score.Brain edema was measured by the wet-dry method.Neuronal apoptosis in the prefrontal cortex was detected by terminal deoxyribonucleotidyl transferase-mediated biotin-16-dUTP nick-end labeling assay.Levels of reactive oxygen species and malondialdehyde in the prefrontal cortex were determined by colorimetry.CHOP,glucose-regulated protein 78,nuclear factor-erythroid2-related factor 2 and heme oxygenase-1 mRNA expression levels in the prefrontal cortex were measured by reverse transcription polymerase chain reaction.Tumor necrosis factor-alpha content in the prefrontal cortex was detected by enzyme linked immunosorbent assay.Immunohistochemical staining was used to detect the number of positive cells of nuclear factor-erythroid 2-related factor 2,heme oxygenase 1,glucose-regulated protein 78,CHOP and glial fibrillary acidic protein.Western blot assay was utilized to analyze the expression levels of nuclear factor-erythroid 2-related factor 2,heme oxygenase 1,glucose-regulated protein 78 and CHOP protein expression levels in the prefrontal cortex.The results showed that resveratrol treatment markedly alleviated neurological deficits and brain edema in experimental subarachnoid hemorrhage rats,and reduced neuronal apoptosis in the prefrontal cortex.Resveratrol reduced the levels of reactive oxygen species and malondialdehyde,and increased the expression of nuclear factor-erythroid 2-related factor 2,heme oxygenase-1 mRNA and protein in the prefrontal cortex.Resveratrol 展开更多
关键词 nerve REGENERATION RESVERATROL oxidative STRESS endoplasmic reticulum STRESS neuroinflammation SUBARACHNOID hemorrhage nuclear factor-erythroid 2-related FACTOR 2 heme oxygenase-1 glucose-regulated protein 78 neural REGENERATION
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Cdyn指导PEEP滴定对机器人辅助前列腺癌根治术老年患者血管外肺水的影响
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作者 苏学森 田首元 +5 位作者 王鑫 聂丽霞 苑昕 张瑞 李超 刘淑芳 《中华麻醉学杂志》 CAS CSCD 北大核心 2019年第4期415-417,共3页
目的评价肺动态顺应性(Cdyn)指导呼气末正压(PEEP)滴定对机器人辅助前列腺癌根治术老年患者血管外肺水的影响。方法择期行机器人辅助前列腺癌根治术患者40例,年龄65~80岁,体重指数19~28 kg/m^2,ASA分级Ⅱ或Ⅲ级。采用随机数字表法分为2... 目的评价肺动态顺应性(Cdyn)指导呼气末正压(PEEP)滴定对机器人辅助前列腺癌根治术老年患者血管外肺水的影响。方法择期行机器人辅助前列腺癌根治术患者40例,年龄65~80岁,体重指数19~28 kg/m^2,ASA分级Ⅱ或Ⅲ级。采用随机数字表法分为2组(n=20):对照组(C组)和PEEP组(P组)。P组分别于气管插管术后即刻、气腹-屈氏体位建立即刻及恢复平卧位时从麻醉机允许的最低PEEP开始,每隔4 min增大2 cmH2O,直到获得最大Cdyn;C组不设置PEEP。P组分别于建立有创动脉压监测即刻(T1)、第1次PEEP滴定成功后10 min(T2)、第2次滴定PEEP成功后10 min、1和2 h(T3-5)、第3次滴定PEEP成功后10 min(T6)和气管拔管后30 min(T7),C组分别于建立T1、气管插管术后10 min(T2)、气腹-屈氏体位建立后10 min、1和2 h(T3-5)、恢复平卧位后10 min(T6)和T7时采集桡动脉血样行血气分析,计算氧合指数。于T1和T7时记录B线评分。结果与C组比较,P组T7时B线评分降低,T5-7时氧合指数升高(P<0.05)。结论Cdyn指导PEEP滴定可降低机器人辅助前列腺癌根治术老年患者血管外肺水生成。 展开更多
关键词 正压呼吸 血管外肺水 前列腺肿瘤 机器人手术 老年人
上海市肺结核病政府减免治疗政策的不断完善 预览
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作者 沈鑫 潘启超 +3 位作者 梅建 袁政安 吴国柱 陈昕 《中国卫生资源》 北大核心 2019年第4期266-268,共3页
新中国成立70年来,我国的结核病防治工作取得了举世瞩目的成就。上海市积极响应国家政策,不断完善结核病防治保障政策,有效保证了各项防治措施的有效落实,上海的肺结核疫情由新中国成立初期的全国最高(患病率4000/10万)降至全国最低(36... 新中国成立70年来,我国的结核病防治工作取得了举世瞩目的成就。上海市积极响应国家政策,不断完善结核病防治保障政策,有效保证了各项防治措施的有效落实,上海的肺结核疫情由新中国成立初期的全国最高(患病率4000/10万)降至全国最低(36/10万)。上海市从21世纪初开始实行肺结核病政府减免治疗政策,逐步加大政府财政资金投入,切实减轻患者经济负担,有效保证了全市肺结核患者成功治疗率维持在90%以上的高水平,促进了肺结核疫情的显著下降。文章介绍了上海市肺结核病政府减免政策不断完善的过程以及取得的成效。 展开更多
关键词 肺结核病 治疗费用 经济负担 减免治疗政策 患病率
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Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome
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作者 Zhenglin Du Liang Ma +27 位作者 Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng 《基因组蛋白质组与生物信息学报:英文版》 CAS CSCD 2019年第3期229-247,共19页
To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy... To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. 展开更多
关键词 De novo assembly Reference GENOME Variation map PHENOTYPE association Large POPULATION
Integrated network analysis of transcriptomic and protein-protein interaction data in taurine-treated hepatic stellate cells 预览
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作者 Xing-Qiu Liang Jian Liang +2 位作者 Xiao-Fang Zhao Xin-Yuan Wang Xin Deng 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第9期1067-1079,共13页
BACKGROUND Studies show that the antifibrotic mechanism of taurine may involve its inhibition of the activation and proliferation of hepatic stellate cells(HSCs).Since the molecular mechanism of taurine-mediated antif... BACKGROUND Studies show that the antifibrotic mechanism of taurine may involve its inhibition of the activation and proliferation of hepatic stellate cells(HSCs).Since the molecular mechanism of taurine-mediated antifibrotic activity has not been fully unveiled and is little studied,it is imperative to use“omics”methods to systematically investigate the molecular mechanism by which taurine inhibits liver fibrosis.AIM To establish a network including transcriptomic and protein-protein interaction data to elucidate the molecular mechanism of taurine-induced HSC apoptosis.METHODS We used microarrays,bioinformatics,protein-protein interaction(PPI)network,and sub-modules to investigate taurine-induced changes in gene expression in human HSCs(LX-2).Subsequently,all of the differentially expressed genes(DEGs)were subjected to gene ontology function and Kyoto encyclopedia of genes and genomes pathway enrichment analysis.Furthermore,the interactions of DEGs were explored in a human PPI network,and sub-modules of the DEGs interaction network were analyzed using Cytoscape software.RESULTS A total of 635 DEGs were identified in taurine-treated HSCs when compared with the controls.Of these,304 genes were statistically significantly up-regulated,and 331 down-regulated.Most of these DEGs were mainly located on the membrane and extracellular region,and are involved in the biological processes of signal transduction,cell proliferation,positive regulation of extracellular regulated protein kinases 1(ERK1)and ERK2 cascade,extrinsic apoptotic signaling pathway and so on.Fifteen significantly enriched pathways with DEGs were identified,including mitogen-activated protein kinase(MAPK)signaling pathway,peroxisome proliferators-activated receptor signaling pathway,estrogen signaling pathway,Th1 and Th2 cell differentiation,cyclic adenosine monophosphate signaling pathway and so on.By integrating the transcriptomics and human PPI data,nine critical genes,including MMP2,MMP9,MMP21,TIMP3,KLF10,CX3CR1,TGFB1,VEGFB,and EGF,were identified 展开更多
关键词 TAURINE Hepatic stellate cells DIFFERENTIALLY EXPRESSED genes Liver FIBROGENESIS TRANSCRIPTOMIC PROTEIN-PROTEIN interaction network
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不同内脏肥胖指标及人体测量学指标对非肥胖透析患者代谢综合征的诊断效能
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作者 周朝敏 唐昕 +5 位作者 袁静 林鑫 胡英 余芳芳 郄淑文 查艳 《中华肾脏病杂志》 CAS CSCD 北大核心 2019年第4期302-304,共3页
本研究旨在比较不同内脏肥胖指标及人体测量学指标对非肥胖维持性血液透析(MHD)患者代谢综合征(MS)的诊断效能。纳入多中心1302例非肥胖MHD患者,收集身高、腰围(WC)、血生化等指标。计算中国人内脏脂肪指数(CVAI)、内脏脂肪指数(VAI)、... 本研究旨在比较不同内脏肥胖指标及人体测量学指标对非肥胖维持性血液透析(MHD)患者代谢综合征(MS)的诊断效能。纳入多中心1302例非肥胖MHD患者,收集身高、腰围(WC)、血生化等指标。计算中国人内脏脂肪指数(CVAI)、内脏脂肪指数(VAI)、脂肪堆积产物指数(LAP)、身体圆度指数(BRI)及体重指数(BMI)、腰高比(WHtR),采用受试者工作特征曲线(ROC)评估非肥胖MHD患者发生MS的最佳诊断指标。结果发现,各指标的ROC曲线下面积(AUC)大小在男性中排序为:LAP(AUC=0.84)>VAI(AUC=0.82)>CVAI(AUC=0.77)>WC(AUC=0.76)>WHtR(AUC=0.75)/BRI(AUC=0.75)>BMI(AUC=0.69);在女性中排序为:LAP(AUC=0.85)>VAI(AUC=0.84)>WC(AUC=0.77)>WHtR(AUC=0.75)/BRI(AUC=0.75)>CVAI(AUC=0.73)/BMI(AUC=0.73)。作者认为,LAP及VAI诊断非肥胖MHD患者MS的效能强于CVAI、BRI、WC、WHtR及BMI;LAP简单、易获取,诊断效能高,可作为初步诊断非肥胖MHD患者MS的简便指标。 展开更多
关键词 身体测量 肥胖症 肾透析 代谢综合征
微藻处理重金属污染技术研究进展 预览
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作者 曹欣 苏苑 +3 位作者 闫欣 管云雷 陈宇华 魏群 《华北水利水电大学学报:自然科学版》 2019年第5期31-35,共5页
随着社会经济的发展,我国工业水平不断提高,工业生产过程中产生的含重金属废水的排放量越来越大,使水体重金属污染越来越严重。目前,常用的重金属污染水体处理技术又存在处理成本高、容易造成二次污染等缺点。微藻作为水体中常见的微生... 随着社会经济的发展,我国工业水平不断提高,工业生产过程中产生的含重金属废水的排放量越来越大,使水体重金属污染越来越严重。目前,常用的重金属污染水体处理技术又存在处理成本高、容易造成二次污染等缺点。微藻作为水体中常见的微生物,对重金属具有一定的吸附作用,利用其处理水体中的重金属具有经济、高效等特点。大量研究表明,微藻能够有效去除水体中的重金属,但温度、重金属浓度、pH值、水体中其他阳离子等因素对重金属处理效果有很大的影响。综述了微藻处理重金属污染水体的研究现状、影响因素及其去除重金属的机理,为进一步研究微藻处理重金属污染技术提供参考。 展开更多
关键词 微藻 处理技术 重金属污染
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原发性开角型青光眼患者甲皱襞微循环的初步观察 被引量:1
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作者 田佳鑫 李猛 +5 位作者 辛晨 谢媛 石砚 桑景荭 王怀洲 王宁利 《眼科》 CAS 2019年第1期17-23,共7页
目的研究原发性开角型青光眼(primary open angle glaucoma,POAG)患者的甲皱襞微循环情况。设计前瞻性比较性病例系列。研究对象POAG患者51例包括高眼压性青光眼(high tension glaucoma,HTG)34例、正常眼压性青光眼(normal tension glau... 目的研究原发性开角型青光眼(primary open angle glaucoma,POAG)患者的甲皱襞微循环情况。设计前瞻性比较性病例系列。研究对象POAG患者51例包括高眼压性青光眼(high tension glaucoma,HTG)34例、正常眼压性青光眼(normal tension glaucoma,NTG)17例;正常受试者70例(对照组)。方法用甲皱襞微循环检测仪(JH-1004显微镜)对受试者非主导手无名指行甲皱襞微循环检测。观察甲皱襞毛细血管出血情况,测量毛细血管密度、无血管区间距(两毛细血管近端平行距离),毛细血管动脉支及静脉支管径(管径最宽距离),计算无血管区>200μm、毛细血管扩张(动脉支管径>15μm或静脉支管径>20μm)存在的例数及评分。以血管扩张为例,0处、1处、2处、≥3处血管扩张分别评分为0、1、2、3。主要指标甲皱襞毛细血管密度,无血管区>200μm、毛细血管出血、毛细血管扩张存在例数及评分。结果HTG组、NTG组和对照组甲皱襞毛细血管密度的中位数(四分位数间距)分别为9(9,10)、10(9,10)和10(9,10)(χ^2=4.123,P=0.127);出现无血管区>200μm者分别为20例(58.8%)、8例(47.1%)和27例(38.6%)(χ^2=3.894,P=0.143);出现毛细血管出血者分别为15例(44.1%)、6例(35.3%)和18例(25.7%)(χ^2=3.633,P=0.163);出现毛细血管扩张者分别为18例(52.9%)、7例(41.2%)和21例(30.0%)(χ^2=5.195,P=0.074),其中POAG组与对照组相比,χ^2=4.492,P=0.034。HTG组、NTG组和对照组无血管区评分的中位数(四分位数间距)分别为1(0,1.25)、0(0,1)和0(0,1)(χ^2=3.842,P=0.146);毛细血管出血评分的中位数(四分位数间距)分别为0(0,1)、0(0,1)和0(0,1)(χ^2=3.156,P=0.206);毛细血管扩张评分的中位数(四分位数间距)分别为1(0,2)、0(0,1)和0(0,1)(χ^2=8.125,P=0.017)。进一步行两组间比较,其中HTG组与对照组相比,差异存在统计学意义(Z=-2.904,P=0.004)。结论POAG患者出现甲皱襞毛细血管异常扩张的情况较正常人明显增多,并且HTG患者出现甲皱襞� 展开更多
关键词 原发性开角型青光眼 甲皱襞毛细血管
Lijiang 2.4-meter Telescope and its instruments
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作者 Chuan-Jun Wang Jin-Ming Bai +32 位作者 Yu-Feng Fan Ji-Rong Mao Liang Chang Yu-Xin Xin Ju-Jia Zhang Bao-Li Lun Jian-Guo Wang Xi-Liang Zhang Mei Ying Kai-Xing Lu Xiao-Li Wang Kai-Fan Ji Ding-Rong Xiong Xiao-Guang Yu Xu Ding Kai Ye Li-Feng Xing Wei-Min Yi Liang Xu Xiang-Ming Zheng Yuan-Jie Feng Shou-Sheng He Xue-Li Wang Zhong Liu Dong Chen Jun Xu Song-Nian Qin Rui-Long Zhang Hui-Song Tan Zhi Li Ke Lou Jian Li Wei-Wei Liu 《天文和天体物理学研究:英文版》 SCIE CAS CSCD 2019年第10期95-108,共14页
The Lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China,has been available to the worldwide astronomical community since 2008. It is located at the Gaomeigu site,Lijiang Observatory... The Lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China,has been available to the worldwide astronomical community since 2008. It is located at the Gaomeigu site,Lijiang Observatory(LJO), in the southwest of China. The site has very good observational conditions.During its 10-year operation, several instruments have been equipped on the LJT. Astronomers can perform both photometric and spectral observations. The main scientific goals of LJT include recording photometric and spectral evolution of supernovae, reverberation mapping of active galactic nuclei, investigating the physical properties of binary stars and near-earth objects(comets and asteroids), and identification of exoplanets and all kinds of transients. Until now, the masses of 41 high accretion rate black holes have been measured, and more than 168 supernovae have been identified by the LJT. More than 190 papers related to the LJT have been published. In this paper, the general observation conditions of the Gaomeigu site is introduced at first. Then, the structure of the LJT is described in detail, including the optical, mechanical, motion and control system. The specification of all the instruments and some detailed parameters of the YFOSC is also presented. Finally, some important scientific results and future expectations are summarized. 展开更多
关键词 telescopes Lijiang 2.4-m Telescope-instrumentation photometers-instrumentation spectrographs
树鼩大脑皮层少突胶质前体细胞的分离鉴定 预览
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作者 李明学 黎晓慧 +5 位作者 黄鑫 王璇 张志成 袁园 陆彩霞 孙晓梅 《实验动物与比较医学》 CAS 2019年第4期260-266,共7页
目的建立树鼩大脑皮层少突胶质前体细胞(OPCs)的体外分离、原代培养方法,以及鉴定技术。方法新生48 h内给树鼩施行安死术后采集大脑,去除脑膜和脑干,留下大脑皮层,然后使用胰酶和DNase I联合消化大脑皮层,分离细胞原代培养。通过采用化... 目的建立树鼩大脑皮层少突胶质前体细胞(OPCs)的体外分离、原代培养方法,以及鉴定技术。方法新生48 h内给树鼩施行安死术后采集大脑,去除脑膜和脑干,留下大脑皮层,然后使用胰酶和DNase I联合消化大脑皮层,分离细胞原代培养。通过采用化学分离法和差速贴壁法从原代培养中获得较为纯化的OPCs。对纯化和定向分化的细胞分别进行硫酸软骨素蛋白多糖4(NG2)、髓鞘碱性蛋白(MBP)细胞免疫荧光染色鉴定。结果纯化后的OPCs,胞体圆形或椭圆形,折光性强,有两极或三极突起,经NG2细胞免疫荧光染色,细胞纯度达97%左右。加入分化培养液后,OPCs可分化发育成熟,经MBP细胞免疫荧光染色为阳性。结论成功建立了树鼩大脑皮层OPCs的体外分离纯化培养方法。 展开更多
关键词 少突胶质前体细胞(OPCs) 大脑皮层 原代细胞培养 分离纯化 树鼩
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Facile synthesis of Li2S@C composites as cathode for Li-S batteries 预览
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作者 Xin Chen Linfeng Peng +7 位作者 Lixia Yuan Rui Zeng Jingwei Xiang Weilun Chen Kai Yuan Jie Chen Yunhui Huang Jia Xie 《能源化学:英文版》 CSCD 2019年第10期111-116,共6页
Lithium sulfide (Li2S) provides a promising route for lithium storage due to high theoretical specific capacity (1166 mAh g-1). The electrochemical performance of Li2S can be significantly enhanced by forming Li2S-car... Lithium sulfide (Li2S) provides a promising route for lithium storage due to high theoretical specific capacity (1166 mAh g-1). The electrochemical performance of Li2S can be significantly enhanced by forming Li2S-carbon composites with the introduction of carbon. However, the complex synthesis method of Li2S-carbon composites restrains the large-scale productivity. Herein, we propose a facile route to prepare carbon coated Li2S-carbon nanotube composites (Li2S@C-CNT) via spray drying and heat treatment, which is a low-cost and large-scale method for facile synthesis of Li2S-carbon composites. For the Li2S@C-CNT composites, Li2S nanoparticles are contacted with surrounding particles due to the 3D CNTs framework. The novel construction not only suppresses the diffusion of polysulfides during cycling, but also remarkably accelerates the transport of electron and ion, resulting in a high specific capacity (1100 mAh g^-1) and good cycling performance. The rational designed architecture and good electrochemical performance of Li2S@C-CNT will pave the avenue for realizing high energy density of Li2S-based batteries. 展开更多
关键词 SPRAY DRYING Li2S@C-CNT Lithium-sulfur BATTERIES
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