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Primary Bladder Adenocarcinoma: A Five-Year Retrospective Clinicopathologic Study of 42 Cases in Egyptian NCI (2010-14) 预览
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作者 Yahia Ismail Amr Kamal +2 位作者 Osama Yousof Neveen Tahoun Rasha Allam 《癌症治疗(英文)》 2019年第1期97-116,共20页
Aim: Globally, primary adenocarcinoma (AC) accounts for only 0.5% - 2% of bladder cancer (BC). Bilharziasis predisposes to AC in ~10% of BC in endemic regions. The aim was to study the clinicopathologic characteristic... Aim: Globally, primary adenocarcinoma (AC) accounts for only 0.5% - 2% of bladder cancer (BC). Bilharziasis predisposes to AC in ~10% of BC in endemic regions. The aim was to study the clinicopathologic characteristics of this rare entity and define prognostic elements influencing disease-free (DFS) & overall survival (OS). Patients & Methods: A retrospective analysis of 42 cases of primary bladder AC presented to the National Cancer Institute of Egypt (NCI-E) during a five-year period (2010-2014), clinicopathologic profiles, management and survival were assessed. Results: The mean age was 55.5 years ± 9.77 with male predominance. Hematuria, bilharziasis & urachal type experienced in 88%, 35.7% & 4.8%, respectively. Radical surgery was employed in 64.3%. Metastatic disease (stageIVB) found in 14.3%, initially. Eleven patients (26.2%) received palliative chemotherapy for their advanced or metastatic disease, objective response rates (ORR) were 0% & 100% for those received gemcitabine/platinum & capecitabine/oxaliplatin, respectively. The 5-year DFS & OS rates were 40.7% & 27%, respectively. DFS was significantly enhanced in patients having GII, negative nodes (pN0) and absence of hydronephrosis (p = 0.001, 0.011 & 0.047, respectively). Presentation with hematuria, pN0 & stage II was linked significantly with longer OS (p = 0.007, 0.037 & < 0.001, respectively). Tumour grade & clinical stage were independent prognostic factors affecting DFS & OS, respectively on multivariate analysis. Conclusions: Notable reduction in incidence of bladder AC in Egypt is mostly due to decline in bilharzial infection. Tumor grade & clinical stage are independent prognostic factors for DFS & OS, respectively. Still no agreement about the role of adjuvant radiotherapy or chemotherapy, however, protocols employed for colorectal cancer seem to be profitable in advanced and metastatic cases. Further larger scale studies are needed to define the hazard factors, molecular characterises and optimal management of this rare type of BC. 展开更多
关键词 Bladder Cancer PRIMARY Adenocarcinoma BILHARZIASIS NCI Egypt
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Hepatoprotective effects of Astragalus kahiricus root extract against ethanol-induced liver apoptosis in rats
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作者 Rasha M.Allam Dina A.Selim +7 位作者 Asser I.Ghoneim Mohamed M.Radwan Salwa M.Nofal Amani E.Khalifa Ola A.Sharaf Soad M.Toaima Aya M.Asaad Nadia A.El-Sebakhy 《中国天然药物》 SCIE CAS CSCD 2013年第4期354-361,共8页
距骨 kahiricus (Fabaceae ) 的乙醇摘录的 hepatoprotective 活动对导致乙醇的肝 apoptosis 的根通过不同机制被评估,它出现了很有希望的 hepatoprotective 行动。摘录抵抗了导致乙醇的肝酶漏和谷胱甘肽弄空。另外,它证明 anti-apopt... 距骨 kahiricus (Fabaceae ) 的乙醇摘录的 hepatoprotective 活动对导致乙醇的肝 apoptosis 的根通过不同机制被评估,它出现了很有希望的 hepatoprotective 行动。摘录抵抗了导致乙醇的肝酶漏和谷胱甘肽弄空。另外,它证明 anti-apoptotic 对被肝证实的 caspase-3 激活和 DNA 破碎完成组织病理学说的检查。而且,这篇摘录的 phytochemical 学习导致了作为 astrasieversianin 识别的四 cycloartane 类型 triterpenes 的隔离 II (1 ) , astramembrannin II (2 ) , astrasieversianin XIV (3 ) ,和 cycloastragenol (4 ) 。这些的结构孤立被 HRESIMS 和 1D 和 2D NMR 实验建立。isolates 的抗菌剂,抗疟药,和细胞毒素的活动进一步被评估,但是任何一个都没他们显示出任何活动。 展开更多
关键词 实验药理学 药理 病理作用 天然药物
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