期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Mastabol 导致了尖锐 cholestasis : 一份案例报告 认领
1
作者 Brett M Hymel David W Victor +2 位作者 Luis Alvarez Nathan J Shores Luis A Balart 《世界肝病学杂志:英文版(电子版)》 2013年第3期133-136,共4页
A 26-year-old male presented with three weeks of jaundice after the self-initiation of the injectable anabolic steroid, Mastabol [Dromastanolone Di-Propionate (17 beta-Hydroxy-2alpha-methyl-5alpha-androstan-3one prop... A 26-year-old male presented with three weeks of jaundice after the self-initiation of the injectable anabolic steroid, Mastabol [Dromastanolone Di-Propionate (17 beta-Hydroxy-2alpha-methyl-5alpha-androstan-3one propionate)]. He reported dark urine, light stools, and pruritus. He denied abdominal pain, intravenous drug use, intranasal cocaine, blood transfusions, newly placed tattoos, or sexually transmitted diseases. He used alcohol sparingly. Physical exam revealed jaundice with deep scleral icterus. The liver was palpable 2 cm below the right costal margin with no ascites. The peak bilirubin was 23.6 mg/dL, alkaline phosphatase was 441 units/L, and aspartate aminotransferase/alanine aminotransferase were 70 units/L and 117 units/L respectively. A working diagnosis of acute intrahepatic cholestasis was made. Liver biopsy revealed a centrilobular insult with neutrophilic infiltrates and Ito cell hyperplasia consistent with acute drug induced cholestasis. The patient’ s clinical symptoms resolved and his liver enzymes, bilirubin, and alkaline phosphatase normalized. Anabolic steroids with 17 alpha carbon substitutions have been associated with a bland variety of cholestatic injury with little hepatocellular injury. Cholestasis, under these circumstances, may be secondary to the binding of drugs to canalicular membrane transporters, accumulation of toxic bile acids from canalicular pump failure, or genetic defects in canalicular transport proteins. Mastabol is an injectable, 17 beta hydroxyl compound with no alpha alkyl groups at the 17 carbon position. As such, it has been reported to have little potential toxic effects on the liver. This is the first known reported case of Mastabolinduced cholestatic liver injury. It highlights the need for physicians to consider such widely available substances when faced with hepatic injury of unclear etiology. 展开更多
关键词 Cholestatic Mastabol HEPATIC ANABOLIC STEROIDS
在线阅读 免费下载
Current endoscopic approach to indeterminate biliary strictures 认领 被引量:1
2
作者 David W Victor Stuart Sherman +1 位作者 Tarkan Karakan Mouen A Khashab 《世界胃肠病学杂志:英文版》 SCIE CAS CSCD 2012年第43期6197-6205,共9页
胆汁的苛评被认为不确定,包括 transabdominal 成像什么时候基本病情的检查并且内视镜后退有刷的平淡的 cytologic 的 cholangiopancreatography,是非诊断的。不确定的胆汁的苛评能容易被描绘它可以戏剧性地影响病人结果。恶意的早、... 胆汁的苛评被认为不确定,包括 transabdominal 成像什么时候基本病情的检查并且内视镜后退有刷的平淡的 cytologic 的 cholangiopancreatography,是非诊断的。不确定的胆汁的苛评能容易被描绘它可以戏剧性地影响病人结果。恶意的早、精确的诊断为外科,而且潜在的及时指向的化疗影响不仅病人候选。有不确定的胆汁的苛评的病人的重要部分因此,良性的疾病和精确诊断是首要的避免不必要的外科。当前的采样策略为恶意的诊断有非最优的精确性。另外的诊断形式上的新兴的数据单个操作符 cholangioscopy,和内视镜的指导 ultrasonography 的罚款例如辅助细胞学技术,刺破渴望,有许多改进敏感的揭示有希望的结果。 展开更多
关键词 狭窄 胆道 诊断方法 视镜 恶性肿瘤 化疗药物 采样策略 检查技术
在线阅读 免费下载
上一页 1 下一页 到第
使用帮助 返回顶部 意见反馈