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Characterization and Release Kinetics of Metronidazole Loaded Silver Nanoparticles Prepared from <i>Carica papaya</i>Leaf Extract 预览
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作者 Tenderwealth Clement Jackson Akeem Ayodeji Agboke +3 位作者 Edidiong Jumbo Udofa Adaeze Salome Ucheokoro Blessing Edidiong Udo Nonye Linda Ifekpolugo 《纳米粒子(英文)》 2019年第3期47-54,共8页
Silver nanoparticles were synthesized using eco-friendly method with the extract of Carica papaya as a reducing and stabilizing agent. Metronidazole 200 mg was loaded as a model drug to the silver nanoparticles. The p... Silver nanoparticles were synthesized using eco-friendly method with the extract of Carica papaya as a reducing and stabilizing agent. Metronidazole 200 mg was loaded as a model drug to the silver nanoparticles. The percentage yield of the metronidazole nanoparticle was high (96.00%). The entrapment efficiency 85.60% while the loading capacity was 8.90%. Differential scanning calorimetry showed there was no interaction between the reducing agent and model drug. Characterization of the metronidazole malpractices using UV- vis spectroscopy, zeta sizer, scanning electron microscopy (SEM) was performed. The UV-Vis spectroscopy showed surface plasmon resonance of 435nm for the silver nanoparticle. The mean particle size was 250 nm while the polydispersity index was 0.22. The metronidazole nanoparticle showed an extended and controlled release profile. The kinetics of release was zero-order (R2 = 0.9931) for the metronidazole nanoparticle while the metronidazole normal release tablet followed Higuchi kinetics (R2 = 0.9745). 展开更多
关键词 Silver Nanoparticles ECO-FRIENDLY Synthesis CHARACTERIZATION Kinetics
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Eco-Friendly Synthesis of Silver Nano Particles Using <i>Carica papaya</i>Leaf Extract 预览
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作者 Tenderwealth Clement Jackson Timma Oto-Obong Uwah +2 位作者 Akeem Ayodeji Agboke Blessing Edidiong Udo Edidiong Michael Udofa 《软纳米科学报(英文)》 2018年第1期1-7,共7页
Silver nanoparticles were synthesized using eco-friendly method with extract of Carica papaya as reducing and stabilizing agent. The silver precursor used was silver nitrate solution. A visible colour change from colo... Silver nanoparticles were synthesized using eco-friendly method with extract of Carica papaya as reducing and stabilizing agent. The silver precursor used was silver nitrate solution. A visible colour change from colourless to reddish brown confirmed the formation of the nanoparticles and the UV-Vis spectroscopy showed surface plasmon resonance of 435 nm for the silver nanoparticle. The mean particle size was 250 nm while the polydispersity index was 0.22. The antimicrobial activity of the synthesized nanoparticles was studied against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis and Staphylococcus aureus. The silver nanoparticles biosynthesized showed satisfactory antimicrobial activity against the test isolates. Antimicrobial property of the nanoparticles was similar (P > 0.05). Generally, MIC values of the samples against the microorganisms tested ranged from 25 - 100 mg/ml. Pseudomonas aeruginosa was most sensitive while Staphylococcus aureus and Bacillus subtilis were least sensitive to the silver nanoparticles. 展开更多
关键词 SILVER NANOPARTICLES ECO-FRIENDLY Method Characterisation ANTIMICROBIAL
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