期刊文献+

SLE患者血浆β-内啡肽和ACTH水平变化及临床意义 预览 被引量:1

Detection and the significance of beta- endorphin and ACTH in systemic lupus erythematosus
在线阅读 下载PDF
收藏 分享 导出
摘要 目的:探讨β-内啡肽(β-endorphin,β-EP)、促肾上腺皮质激素(ACTH)是否与SLE的发病有关.方法:采用放射免疫分析法测定30例SLE患者血浆β-内啡肽、ACTH水平,并与20例正常对照组相比较.结果:SLE患者血浆β-内啡肽水平与正常对照组相比显著降低,P<0.01;ACTH水平与正常对照组相比差异无显著性,P>0.05.结论:结果表明β-内啡肽与SLE发病可能存在一定关系. Objective: To investigate the relationship between beta-endorphin (β-EP), ACTH in the pathogensis of systemic lupus erythematosus (SLE). Methods: Radio-immunoassay method was employed to detect the concentration of β-EP and ACTH in the plasma of 30 cases of SLE and to compare it with 20 normal controls. Results: Compared with normal controls, the plasma level of β-EP in untreated SLE patients were significantly decreased (P<0.01), while there was no significant difference in plasma level of ACTH in SLE patients (P>0.05). Conclusion: The changes of β-EP and ACTH might be relevant to the pathogenesis of SLE.
作者 李久宏 刘继峰 李波 翟宁 耿龙 宋芳吉 Li Jiuhong, Liu Jifeng, Li Bo, et al. Department of Dermatology, The First Hospital of China Medical University, Shenyang, 110001
出处 《中国麻风皮肤病杂志》 北大核心 2003年第4期323-324,共2页 China Journal of Leprosy and Skin Diseases
关键词 SLE 血浆 Β-内啡肽 ACTH 促肾上腺皮质激素 放射免疫分析法 systemic lupus erythematosus beta-endorphin ACTH
  • 相关文献

参考文献6

  • 1陈金.SLE的心理因素研究进展[J].国外医学:皮肤性病学分册,1995,21(1):7-9. 被引量:21
  • 2薛建中 王成海.烧伤病人血浆β—内啡肽样活性物质含量的变化及其临床意义[J].中华整形烧伤科杂志,1997,7:253-256. 被引量:1
  • 3Mansour A, Fox CA, Akil H, et al. Opioid - receptor mRNA expression in the rat CNS: anatomical and functional implications.Trends Neurosci 1995;18:22-29. 被引量:1
  • 4vMorch H, Pedersen BK. Beta- endorphin and the immune system-possible role in autoimmune diseases. Autoimmunity 1995;21:161- 171. 被引量:1
  • 5兰海梅 刘晓加.系统性红斑狼疮患者心理健康状况调查[J].中华皮肤科杂志,2000,33:40-40. 被引量:2
  • 6Ward MM, Lotstein DS, Bush TM, et al. Psychosocial correlates of morbidity in women with systemic lupus erythematosus. J Rheumatol 1999;26:2153 - 2158. 被引量:1

共引文献21

同被引文献25

  • 1覃志成,陈洪宇,王永钧.脂质介导的肾损伤[J].中国中西医结合肾病杂志,2006,7(5):299-301. 被引量:4
  • 2徐虹.肾病综合征激素治疗及效果评价[J].中国实用儿科杂志,2007,22(6):410-412. 被引量:6
  • 3姚璐,郑伟,赵莲,王波,王广义,王字玲,周虹.ACTH(1—24)对脂多糖致ECV304细胞损伤的保护作用[J].医学分子生物学杂志,2007,4(4):311-314. 被引量:1
  • 4朱辟疆.肾病综合征血浆ACTH,皮质醇与中医证型关系的研究[J].浙江中西医结合杂志,1997,7(4):193-194. 被引量:9
  • 5Ito M,Seki T,Takuma Y.Current therapy for West syndrome in Japan.J Child Neurol,2000,15(6):424~428. 被引量:1
  • 6Abeyagunawardena AS,Hindmarsh P,Trompeter RS.Adrenocortical suppression increases the risk of relapse in nephrotic syndrome.Arch Dis Child,2007,92(7):585~588.PMID:17284479. 被引量:1
  • 7Tordjman K,Jaffe A,Trostanetsky Y,et al.Low-dose (1 microgram) adrenocorticotrophin (ACTH) stimulation as a screening test for impaired hypothalamo-pituitary-adrenal axis function:sensitivity,specificity and accuracy in comparison with the high-dose (250 microgram) test.Clin Endocrinol (Oxf),2000,52(5):633~640.PMID:10792344. 被引量:1
  • 8Yang Y,Liu L,Zhao B.Relationship between adrenal function and prognosis in patients with severe sepsis.Chin Med J(Engl),2007,120(18):1578~1582.PMID:19640370. 被引量:1
  • 9Zhihui Y,Shumei C,Rengui W,et al.Value of ACTH in children with corticoid dependent nephrosis.9 th Asian Congress of Pediatric Nephrology,2005.90~91. 被引量:1
  • 10Aoife Brennan,Kieran A.O'Connor,William D.Plant and Domhnaill J.O'Halloran:Nephrotic syndrome:cause of an abnormal response to the rapid ACTH stimulation test:Nephrol Dial Transplant,2004,19:477~478.PMID:14736978. 被引量:1

引证文献1

二级引证文献4

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈