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郑州市2012-2017年重症手足口病病原学监测及流行病学分析

Epidemiological and etiological features of severe hand-foot-mouth disease in Zhengzhou in 2012-2017
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摘要 目的分析2012-2017年郑州市重症手足口病(hand foot and mouth disease,HFMD)的病原学监测及流行病学特征,为有效控制HFMD提供科学依据。方法对2012-2017年郑州市报告的重症HFMD病例个案调查和实验室检测资料进行流行病学分析。结果 2012-2017年郑州市共报告HFMD病例105 627例,其中重症病例784例,重症比例为0.74%。HFMD重症男女之比是2.07∶1,3岁以下儿童重症数占总数的77.30%,散居儿童占89.67%;发病主要集中在4~8月(75.89%);地区分布以登封市、新密市和中牟县等郊县的重症率较高。病原学结果显示547例肠道病毒感染,其中EV71阳性比例最高,为424例,占到了所有病例的77.51%,而其他肠道病毒阳性81例,占14.81%,Cox A16阳性42例,占7.68%。结论 EV71感染仍是郑州市重症HFMD病例的主要病毒类型,应重点关注3岁以下儿童和郊区重症病例。 Objective To understand the epidemiological and etiological characteristics of severe hand-foot-mouth disease(HFMD)from 2012 to 2017 in Zhengzhou,and to provide scientific evidence for HFMD prevention and control.Methods An epidemiological analysis was performed on clinical data and laboratory test result data of severe HFMD cases reported in Zhengzhou from 2012 to 2017.Results A total of 105 627 cases of HFMD were reported in Zhengzhou between 2012 and 2017,784 were severe cases(0.74%)with male to female ratio of 2.07∶1 and 77.30%were children under 3 years old and 89.67%were sporadic cases.75.89%of cases appeared in April to August.Most severe cases were in Dengfeng,Xinmi and Zhongmu.Laboratory test showed that among 784 severe cases,547 cases were infected with enterovirus,including 424 of EV71 positive cases(77.51%),42 of Cox A16 positive cases(7.68%)and 81 of other enterovirus positive cases(14.81%).Conclusions EV71 virus is still the major pathogen of severe HFMD during 2012 and 2017.Children under 3 years old are more vulnerable to HFMD.
作者 王璐瑶 李国伟 马莹 周海霞 王静 石爱梅 肖燕 WANG Lu-yao;LI Guo-wei;MA Ying;ZHOU Hai-xia;WANG Jing;SHI Ai-mei;XIAO Yan(Department of Stomatology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,Ch)
出处 《中国预防医学杂志》 CAS CSCD 2019年第7期597-601,共5页 Chinese Preventive Medicine
基金 河南省医学科技攻关计划(201504074) 漯河医学高等专科学校基础科学研究项目(2015-S-LMC01).
关键词 手足口病 重症 流行病学特征 病原学 肠道病毒 HFMD Sever cases Epidemiological feature Etiology Enterovirus
作者简介 王璐瑶,硕士研究生,主治医师,主要从事口腔黏膜病研究;通信作者:肖燕,E-mail:xiaoyan@zzu.edu.cn
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