期刊文献+

丁苯酞注射液对动脉瘤性蛛网膜下腔出血脑血管痉挛患者血清神经特异性烯醇酶、C-反应蛋白及脂肪酸结合蛋白水平的影响 预览 被引量:9

Effect of butylphthalide injection on serum neuron specific enolase,C-reactive protein and fatty acid binding protein levels in patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage
在线阅读 下载PDF
收藏 分享 导出
摘要 探讨丁苯酞注射液对动脉瘤性蛛网膜下腔出血脑血管痉挛患者血清神经特异性烯醇酶、C-反应蛋白及脂肪酸结合蛋白水平的影响。方法收集福建医科大学附属第一医院神经外科收治的动脉瘤性蛛网膜下腔出血术后脑血管痉挛患者90例,分为对照组和实验组,每组各45例,对照组给予尼莫地平和'3H'疗法等常规动脉瘤治疗方法,实验组在对照组的基础上静脉使用丁苯酞注射液。比较患者治疗前后经颅多普勒(transcranial doppler,TCD)血流参数、血清神经特异性烯醇酶(neuron specific enolase,NSE)、脂肪酸结合蛋白(fatty acid binding protein,FABP)、C-反应蛋白(C-reactive protein,CRP)水平。结果实验组患者与对照组相比大脑中动脉血流痉挛参数明显改善(P<0.05);实验组患者治疗后的血清NSE、CRP、FABP水平较低(P<0.05);实验组患者与对照组比较其脑梗死率较低(P<0.05)。结论丁苯酞注射液能够显著降低动脉瘤性蛛网膜下腔出血脑血管痉挛患者血清NSE、CRP以及FABP水平,改善脑部血流,是治疗动脉瘤性蛛网膜下腔出血脑血管痉挛患者的一种有效的联合疗法。 To investigate influence of butylphthalide injection on serum neuron specific enolase, C-reactive protein and fatty acid binding protein levels in patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage.Methods Ninety patients with cerebral vasospasm were admitted to The First Affiliated Hospital of Fujian Medical University, then the patients were divided into two groups: The control group (45 patients) was treated with nimodipine and triple-H therapy after surgery;in addition to nimodipine and triple-H therapy, butylphthalide injection was administered to the experimental group(45 patients).Transcranial doppler(TCD)was used for the evaluating cerebral artery blood flow velocity, and the serum neuron specific enolase(NSE), C-reactive protein(CRP) and fatty acid binding protein(FABP) levels in patients with cerebral vasospasm were measured. Results The experimental group improved significantly more than the control group, a significant decrease in cerebral blood flow velocity of the middle cerebral artery in the experimental group as measured by TCD (P<0.05).The serum levels of NSE, CRP and FABP in the patients in the experimental group decreased more significantly (P<0.05).And the incidence of cerebral infarction in experimental group was lower than that in control group (P<0.05).Conclusion The serum levels of NSE, CRP and FABP in the patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage could be significantly reduced by administration of butylphthalide injection, which also could improve cerebral blood supply.Therefore, administration of butylphthalide injection is an effective treatment for cerebral vasospasm.
作者 郑树法 姚培森 黄小芬 余良宏 王伟 康德智 ZHENG Shu-fa;YAO Pei-sen;HUANG Xiao-fen;YU Liang-hong;WANG Wei;KANG De-zhi;Department of Neurosurgery,The First Affiliated Hospital of Fujian Medical University;Department of Neurology,The First Affiliated Hospital of Fujian Medical University
出处 《中国生化药物杂志》 CAS 2015年第10期44-47,共4页 Chinese Journal of Biochemical Pharmaceutics
基金 福建省临床重点专科建设项目
关键词 丁苯酞注射液 脑血管痉挛 神经特异性烯醇酶 C-反应蛋白 特异性烯醇酶 脂肪酸结合蛋白 butylphthalide injection aneurysmal subarachnoid hemorrhage cerebral vasospasm neuron specific enolase C-reactive protein fatty acid binding protein
  • 相关文献

参考文献9

  • 1杨晓东.丁苯酞对K141N突变型HSPB8蛋白致线粒体异常的保护作用[D].浙江大学2014 被引量:1
  • 2徐玉振.丁苯酞对血管性痴呆大鼠学习记忆能力及海马MMP-2、MMP-9表达的影响[D].泰山医学院2011 被引量:1
  • 3康军.丁苯酞对血管性痴呆小鼠胆碱乙酰转移酶代谢影响机制的研究[D].河北医科大学2008 被引量:1
  • 4J. Bellapart,Lee Jones,H. Bandeshe,R. Boots.Plasma Endothelin-1 as Screening Marker for Cerebral Vasospasm After Subarachnoid Hemorrhage[J]. Neurocritical Care . 2014 (1) 被引量:1
  • 5So-Young Park,Mi-Hwa Kim,Ok-Joon Kim,Hee-Jung Ahn,Ji-Ye Song,Ju-Yeon Jeong,Seung-Hun Oh.Plasma heart-type fatty acid binding protein level in acute ischemic stroke: Comparative analysis with plasma S100B level for diagnosis of stroke and prediction of long-term clinical outcome[J]. Clinical Neurology and Neurosurgery . 2012 被引量:2
  • 6Emine Meric,Abdulkadir Gunduz,Suleyman Turedi,Ertugrul Cakir,Mustafa Yandi.The Prognostic Value of Neuron-Specific Enolase in Head Trauma Patients[J]. Journal of Emergency Medicine . 2010 (3) 被引量:3
  • 7BRANDNER S,THALER C,BUCHFELDER M,et al.Brain-derived protein concentrations in the cerebrospinal fluid:contribution of trauma resulting from ventricular drain insertion. Journal of Neurotrauma . 2013 被引量:1
  • 8Hwang SH,Park YS,Kwon JT,et al.Significance of C-Reactive protein and transcranial doppler in cerebral vasospasm following aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc . 2013 被引量:1
  • 9Fathi Ali R,Bakhtian Kamran D,Pluta Ryszard M.The role of nitric oxide donors in treating cerebral vasospasm after subarachnoid hemorrhage. Acta neurochirurgica. Supplement . 2010 被引量:1

共引文献3

同被引文献72

引证文献9

二级引证文献39

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈