目的观察萎胃汤治疗幽门螺旋杆菌(HP)阳性慢性萎缩性胃炎(CAG)的临床疗效及安全性。方法选取2017年12月—2018年12月收治的100例Hp阳性CAG患者作为研究对象,随机分为对照组和观察组,每组50例。对照组采用传统4联疗法进行治疗,观察组在此基础上应用萎胃汤进行治疗。观察2组患者治疗2周后的中医主症(胃痛、痞满)积分、胃镜下黏膜萎缩积分、Hp清除率、临床疗效及治疗期间的不良反应。结果经过治疗后,2组患者胃痛证候积分、痞满证候积分均低于治疗前,且观察组患者胃痛证候积分、痞满证候积分低于对照组,差异均具有统计学意义(P <0. 05)。经过治疗后,2组患者胃镜下黏膜萎缩积分均低于治疗前,且观察组患者胃镜下黏膜萎缩积分低于对照组,差异均具有统计学意义(P <0. 05)。经过治疗后,观察组患者Hp清除率及治疗总有效率高于对照组,差异具有统计学意义(P <0. 05)。2组患者治疗期间均未发生严重不良反应。结论萎胃汤治疗Hp阳性CAG效果确切,可明显减轻患者胃痛、痞满症状,改善患者胃镜下胃黏膜变化,且无明显不良反应,具有较好的临床应用价值。
Objective To observe the clinical efficacy and safety of Weiwei decoction in the treatment of Helicobacter pylori(Hp)-positive chronic atrophic gastritis(CAG).Methods From December 2017 to December 2018,100 Hp-positive CAG patients admitted to our hospital were randomly divided into control group and observation group,with 50 cases in each group.The control group was treated with traditional therapy.The observation group was treated with Weiwei decoction.The scores of main symptoms of traditional Chinese medicine(stomach pain,fulles),endoscopic mucosal atrophy score,Hp clearance rate,clinical efficacy and adverse reactions during treatment were observed after 2 weeks of treatment.Results After treatment,the scores of stomach pain syndrome and the syndrome were lower than those before treatment,and the scores of these in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of mucosal atrophy in the two groups were lower than those before treatment,and the scores of mucosal atrophy in the observation group were lower than those in the control group(P<0.05).After treatment,the Hp clearance rate and total effective rate of the observation group were higher than those of the control group(P<0.05).No serious adverse reactions occurred during the treatment period in both groups.Conclusion Weiwei decoction is effective in the treatment of Hp-positive CAG,which can significantly alleviate the symptoms of stomach pain and fullness in patients,improve the gastric mucosal changes under endoscopy,and has no obvious side effects.It has good clinical application value.
GUANGMING JOURNAL OF CHINESE MEDICINE
chronic atrophic gastritis
therapy of TCM